(3) L. donovani (1) (1)

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2 (1) Leishmania infantum zoonotic L. donovani anthroponotic 1 1. Leishmania infantum L. donovani. (2) 4 TNF-α IL-10 (aly/aly) Foxp3 + CD4 + T (T, Treg) L. infantum L. donovani Treg (3) nm L. donovani (1) (2) T (Treg)(3) (1)

(Kalazar Detect TM, rk39 dipstick) rk39 DNA DNA ITS PCR (ITS-PCR) (2) 1 3 L.

3 x 10 9 13-01491 1, 3, 5 8 8 (Alb, A/G, GOP, GPT, γ-gt, UN, CRE)DNA ITS-PCR

3 (Kalazar Detect TM, rk39 dipstick) rk39 DNA DNA ITS PCR (ITS-PCR) (2) 1 3 L. donovani promastigote 4.3 x , 3, (Alb, A/G, GOP, GPT, γ-gt, UN, CRE)DNA ITS-PCR DNA (kdna) real-time PCR (kdna-qpcr) CD4 + T cell CD8 + T cellcd25 + T cellfoxp3 + PCR (3) L. donovani 34 (ExoQuick TM ) (MALDI-TOF-MS) (1) rk ITS-PCR 4 3. rk39 dipstick. 4. ITS-PCR DNA (2) P ITS-PCR kdna-qpcr CD4 + CD25 + Foxp3 + (Treg)CD4 + T 6 5

5. CD4 + CD25 + Foxp3 + (Treg)CD4 + T. 3 HE 3 1 90 kda 8 690 kda 6.. (PC).1235 8 01m2m3m5m8m 100 2 HRP protein G ECL Plus TM. 2 1 2 4 PCR 2 DNA 8 L. donovani (3) L.

4 5. CD4 + CD25 + Foxp3 + (Treg)CD4 + T. 3 HE kda kda 6.. (PC) m2m3m5m8m HRP protein G ECL Plus TM PCR 2 DNA 8 L. donovani (3) L. donovani MALDI-TOF-MS Mascot Search probable eukaryotic inhibition factor 4A, 40S ribosomal protein SA, probable 60S ribosomal protein L14, heat shock 70 kda protein, receptor-type adenylate cyclase A, S-adenosylmethionine synthase, elongation factor Ts (mitochondrial), histon H3, kinesin-like protein K39 (fragment), leishmanolysin, protein phosphatase 2C 15 (LC-MS/MS) (GO) 12 Terao M, Akter S, Yasin Md.G, Nakao R, Kato H, Alam MZ, Katakura K: Molecular detection and genetic diversity of Babesia gibsoni in dogs in Bangladesh. Infect Genet Evol 31:53-60, doi: /j.meegid Ikeda T, Yoshimura M, Onoyama K, Oku Y, Nonaka N, Katakura K: Where to deliver baits for deworming urban red foxes for Echinococcus multilocularis control: new protocol for micro-habitat modeling of fox denning requirements. Parasit Vectors

5 7(1):357, doi: / Alam MZ, Bhutto AM, Soomro FR, Baloch JH, Nakao R, Kato H, Schönian G, Uezato H, Hashiguchi Y, Katakura K: Population genetics of Leishmania (Leishmania) major DNA isolated from cutaneous leishmaniasis patients in Pakistan based on multilocus microsatellite typing. Parasit Vectors 7(1): 332, doi: / Chiba R, Amagai Y, Tanaka A, Katakura K, Matsuda H.: Nerve growth factor promotes killing of Leishmania donovani by macrophages through the induction of hydrogen peroxide. Microbes Infect 16(8): , doi: / j.micinf Bawm S, Shimizu K, Hirota J, Tosa Y, Htun LL, Maw NN, Thein M, Kato H, Sakurai T, Katakura K: Molecular prevalence and genetic diversity of bovine Theileria orientalis in Myanmar. Parasitol Int 63(4): , doi: /j.parint Alam MZ, Nakao R, Sakurai T, Kato H, Qu J-Q, Chai J-J, Chang K-P, Schönian G, Katakura K: Genetic diversity of Leishmania donovani/infantum complex in China through microsatellite analysis. Infect Genet Evol 22, , doi: /j.meegid Nzelu CO, Gomez EA, Cáceres AG, Sakurai T, Martini-Robles L, Uezato H, Mimori T, Katakura K, Hashiguchi Y, Kato H: Development of a loop-mediated isothermal amplification method for rapid mass-screening of sand flies for Leishmania infection. Acta Trop 132:1-6, doi: /j.actatropica : III.40 (4) , category_id=37 :. 11 (2) 61-70, Alam MZ, Yasin MG, Kato H, Sakurai T, Katakura K: PCR-based detection of Leishmania donovani DNA in a stray dog from a visceral leishmaniasis endemic focus in Bangladesh. J Vet Med Sci 75, 75-78, doi: /jvms Tiwananthagorn S, Iwabuchi K, Ato M, Sakurai T, Kato H, Katakura K: Involvement of CD4 + Foxp3 + regulatory T cells in persistence of Leishmania donovani in the liver of alymphoplastic aly/aly mice. PLoS Negl Trop Dis 6, e1798, doi: /journal.pntd Tiwananthagorn S, Bhutto AM, Baloch JH, Soomro FR, Kawamura Y, Nakao R, Aoshima K, Nonaka N, Oku Y, Katakura K: Zoophilic feeding behaviour of phlebotomine sand flies in the endemic areas of cutaneous leishmaniasis of Sindh Province, Pakistan. Parasitol Res 111, , doi: /s , Alam M,,,, Chang KP, Schönian G: Population genetics of Leishmania donovani/ infantum complex in China by multilocus microsatellite analysis Katakura K: Molecular epidemiological studies on livestock parasites in Myanmar. First International Conference and the 13 th Annual Meeting of Myanmar Veterinary Association, , Yangon Convention Center, Yangon, Myanmar Alam MZAkter S Alam MZ, Nakao R, Sakurai T, Kato H, Chang KP, Schönian G, Katakura K Multilocus microsatellite typing of Leishmania infantum parasites from China. Fifth World Congress on Leishmaniasis Enotel Resort & Spa, Porto de Galinhas Alam MZ, Akter S, Yasin Md.G, Serological and molecular evidence of Leishmania parasite in dogs of visceral leishmaniasis endemic areas in Bangladesh Alam M,,,, Chang KP, Schönian G, Genetic

6 polymorphism of Chinese Leishmania infantum strains revealed by multilocus microsatellite analysis Tiwananthagorn S aly/aly T II (pp ) html (1) (KATAKURA, Ken) (2) (KATO, Hirotomo) (3) (TAKIGUCHI, Mitsuyoshi) (ATO, Manabu)

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