Preparation of Novel Microcapsules by Emulsion Droplet Template Method

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1 20 7Π PROGRESS IN CHEMISTRY Vol. 20 No. 7Π8 Aug., ( ),(colloidosome),,, : O ; TB383 : A : X(2008) 07Π Preparation of Novel Microcapsules by Emulsion Droplet Template Method Liu Hongxia Wang Chaoyang 3 3 Gao Quanxing Tong Zhen ( Research Institute of Materials Science, South China University of Technology, Guangzhou , China) Abstract The present article focuses on a facile and versatile technique of emulsion droplet template method, developed for preparing novel microcapsules. Colloid particles adsorb on the surface of the emulsion droplets and self2 assemble into an ordering spherical solid shell. Cross2linking and fixing the shell, the novel capsulecolloidosome, which is composed of a close2packed shell of colloid particles, can be fabricated. The strategy outlined readily affords the facility of fabrication and precise control over the size, permeability, mechanical strength of the capsules. Consequently these capsules have potential applications in functional foods, drug delivery, biomedicine, especially cell transplant. Key words emulsion droplet template method ; colloid particles ; microcapsules ; self2assembly 1,,, ( ) ( ) ( ) 3 [1 ], : , : (No ) 3 3 e2mail edu. cn,, (colloidosome), ; [2 ]

2 7Π8 1045, [3 ] 2 1, ( ),,,pickering [4 ],, [5 ] ; [6 ], pickering, [7,8 ], [9 ] 2 (a), ( b) [10 ] Fig. 2 Experimental setup (a) and schematic diagram (b) for monodisperse suspension2emulsion generation [10 ] Xu 3, ;,, 1 Fig. 1 Schematic illustration of the self2assembly process for colloidosomes,, Yi [10 ], 2,,,,,,Xu [11 ] Subramaniam [12 ], 3 (a) (b) : (b), [11 ] Fig. 3 ( a ) Experimental setup of microchannel ( MC) emulsification and ( b) schematic of cross2flow type silicon MC plate. The horizontal arrow in ( b) shows the flow direction of the continuous aqueous phase while the vertical arrow shows the injection direction of the dispersed oil phase [11 ] 3 : (1),

3 ;, (2),, ; (3),, ( ), (4),, 4 Velev [8 ],( PS),,, Velev [13 ],,, ( ),,Nikolaides [14,15 ] ( dipolar field) (electrostatic stress),, (capillary force),, Dinsmore [2 ], ( PMMA) PS Science (colloidosome), (liposome), OΠW PΠW PΠO (),: OΠW > PΠW - PΠO OΠW,,,, 4. 1 (), Cayre [3 ],,PS,, PS PS, Dinsmore [2,16 ] 105 ( PS 100 ) PS,, PS, 4. 2 Lawrence [17 ] N2, N2 242, N2,,,

4 7Π ( 4215 ),13 % ; ( 64 ), 40 % [18 Binks 20 ] 42 (P4VP) SiO 2 ph :ph 3. 4, ;ph = 6, P4VP,,P4VP Gordon [21 ], PS PS, 4. 3, WΠO,, 95, Cayre [3 ] 115 % ( PS ),95 75,,PS,,PS ( 4),,, PS Noble [22 ] Paunov [5 ], Duan [6 ] Fe 3 O 4 : 4 Fig. 4 Schematic illustration of the forming process of agrose gel N = M Fe 3 O 4 V water D NPS d NP M Fe3 O 4 Fe 3 O 4, Fe 3 O 4 (511gΠml), V water, D NPS (m), d NP Fe 3 O 4 (nm) Wang [23,24 ] CaCO 3 5 (a) (b d),c d [23,24 ] Fig. 5 Different magnification optical micrographs of the colloidosomes in oil (a) or in water (b d), c and d are under [23,24 ] crossed polarizer and analyzer Π,, ( GDL) ( EDTA), ph,,wπo, ΠCaCO 3 5 CaCO 3, ;,CaCO 3 WΠO CaCO 3

5 , ( 5b) 4. 4 CdSe,, CdSe,, CdSe, Russell [25 ] [29 ] (cowpea mosaic virus,cpmv) CdSe, CPMV, 4. 5, Ge [32,33 ] CPMV, PS, MF CPMV,pH 4,MF PS,,CPMV PS MF, SFM (scanning force microscopy) SAXS ( small angle X2ray Bon [34 ] PMMA scattering) CPMV (29 2) nm (33, 3) nm,cpmv PMMA CPMV,PMMA, ; Noble [22 ] Paunov [5 ], Chen [35 ] TiO 2,, Croll [26 ], ( PEI),,,,,, Yuan [27 ] (20nm), 22 ;,,,, [28 Lin 31 ] CdSe 5, WΠO WΠO [ 1 ] ( eds. Ma X J, et al. ). (Microcapsules and Artificial Organs). : (Beijing : Chemical Industry Press), 2002 [ 2 ] Dinsmore A D, Hsu M F, Nidolaides M G, et al. Science, 2002, 298 :

6 7Π [ 3 ] Cayre O J, Noble P F, Paunov V N. J. Mater. Chem., 2004, 14 : [ 4 ] Pickering S U. J. Chem. Soc., 1907, 91 : 2001 [ 5 ] Paunov V N, Noble P F, Cayre O J, et al. Mater. Res. Soc. Symp. Proc., 2005, 845 [ 6 ] Duan H W, Wang D Y, Sobal N S, et al. Nano Lett., 2005, 5 : [ 7 ] Tarimala S, Dai L L. Langmuir, 2004, 20 : [ 8 ] Velev O D, Furusawa K, Nagayama K. Langmuir, 1996, 12 : [ 9 ] Duan H W, Wang D Y, Kurth D G, et al. Angew. Chem. Int. Ed., 2004, 43 : [10] Yi G R, Manoharan V N, Klein S, et al. Adv. Mater., 2002, 14 : [11] Xu Q Y, Nakajima M, Binks B P. Colloids and Surfaces A : Physicochem. Eng. Aspects, 2005, 262 : [12] Subramaniam A B, Abkarian M, Stone H A. Nature Materials, 2005, 4 : [13] Velev O D, Lenhoff A M, Kaler E W. Science, 2000, 287 : [14] Bausch A R, Bowick M J, Nikolaides M G, et al. Science, 2003, 299 : [15] Nikolaides M G, Bausch A R, Hsu M F, et al. Nature, 2002, 420 : [16] Hus M F, Nikolaides M G, Dinsmore A D, et al. Langmuir, 2005, 21 : [17] Lawrence D B, Cai T, Hu Z B, et al. Langmuir, 2007, 23 : [18] Fujii S, Read E S, Binks B P, et al. Adv. Mater., 2005, 17 : [19] Binks B P, Murakami R, Armes S P, et al. Langmuir, 2006, 22 : [20] Fujii S, Armes S P, Binks B P, et al. Langmuir, 2006, 22 : [21] Gordon V D, Chen X, Hutchinson J W, et al. J. Am. Chem. Soc., 2004, 126 : [22] Noble P F, Cayre O J, Alargova R G, et al. J. Am. Chem. Soc., 2004, 126 : [23] Wang C Y, Liu H X, Tong Z, et al. ChemPhysChem, 2007, 8 : [24] Liu H X, Wang C Y, Tong Z. et al. Int. J. Pharm., 2008, 351 : [25] Russell J T, Lin Y, Bgker A, et al. Angew. Chem. Int. Ed., 2005, 44 : [26] Croll L M, Stgver H D H. Langmuir, 2003, 19 : [27] Yuan X F, Fischer K, Schgrtl W. Langmuir, 2005, 21 : [28] Lin Y, Skaff H, Emrick T, et al. Science, 2003, 299 : [29] Lin Y, Skaff H, Bgker A, et al. J. Am. Chem. Soc., 2003, 125 : [30] Lin Y, Bgker A, He J B, et al. Nature, 2005, 434 : [31] Lin Y, Bgker A, Skaff H, et al. Langmuir, 2005, 21 : [32] He X D, Ge X W, Wang M Z, et al. Polymer, 2005, 46 : [33] He X D, Ge X W, Wang M Z, et al. Journal of Colloid and Interface Science, 2006, 299 : [34] Bon S A F, Cauvin S, Colver P J. Soft Matter, 2007, 3 : [35] Chen T, Colver P J, Bon S A F. Adv. Mater., 2007, 19 :

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