864 Journal of Ningxia Medical University 34 9 2012 9 1674-6309 2012 09-0864 - 05 1 2 3 1 1 1 1 1 1. 750004 2. 750004 3. 750004 192 PCOS 26 POF 110 L R 2D 3D < 2D 4D < 3D 4D < 2D 5D < 4D 5D < 3D 5D PCOS > > 2D 3D 2D 4D > > PCOS 2D 5DPCOS > POF > 3D 4D 4D 5D 3D 5D > PCOS > 2D 3D PCOS 2D 4D 2D 5D 3D 4D 2D 5D 3D 5D 4D 5D t = 2. 13 1. 98 2. 22-2. 97-2. 55-2. 31 P < 0. 05 PCOS 2D 3D 2D 4D 2D 5D 3D 4D 3D 5D 4D 5D t = - 2. 11 2. 81 3. 20 3. 77 3. 32 2. 10 P < 0. 05 POF 3D 5D 4D 5D 3D 4D t = 2. 54 2. 38 2. 54 P < 0. 05 PCOS t = 6. 04 9. 21 11. 04 7. 82 10. 48 7. 38 P < 0. 01 4D 5D t = 2. 07 2. 72 2. 87 2. 08 P < 0. 05 4D 5D t = 2. 24 P < 0. 05 PCOS 2D 4D χ 2 = 16. 31 12. 14 P < 0. 05 2D 3D 2D 4D 2D 3D 2D 4D PCOS R711. 75 A Digit ratio PCOS 2D 4D 7 PCOS 1 2 Polycystic Ovarian 1 Syndrome PCOS 3 PCOS 1. 1 2008 4 3-2010 9 PCOS 192 5 PCOS Premature Ovarian POF 26 Failure POF B PCOS 110 6 PCOS 2003Rotterdam 8 POF 1. 2 2012-01 - 03 81060051 NZ11267 1968 - E - mail zhaojunlii@yahoo. com. cn 9 1. 3 SPSS 17. 5 ± x 珋 ± s

9. 865 t t PCOS POF χ 2 P < 0. 05 BMI T 2 PCOS POF t = 7. 79 4. 52 P < 0. 01 PCOS BMI T 2. 1 t = 3. 34 11. 28 2. 62 10. 69 P < 0. 001 t = 2. 60 P < 0. 05 1 1 PCOS x 珋 ± s n = 110 PCOS n = 192 n = 26 F P / 29. 77 ± 4. 59 25. 76 ± 3. 90 ΔΔ 29. 88 ± 6. 67 ** 37. 45 < 0. 01 110 0 178 14 22 4 96 14 149 43 18 8 / 13. 61 ± 1. 13 14. 23 ± 1. 82 ΔΔ 15. 04 ± 1. 92 ΔΔ* 8. 65 < 0. 01 BMI / kg m - 2 21. 48 ± 2. 47 23. 03 ± 4. 04 ΔΔ 20. 85 ± 2. 51 ** 13. 07 < 0. 01 T / ng dl - 1 29. 71 ± 15. 95 3. 63 ± 24. 50 ΔΔ 19. 40 ± 16. 32 Δ** 76. 61 < 0. 01 Δ P < 0. 05 ΔΔ P < 0. 01 PCOS * P < 0. 05 ** P < 0. 01 2. 2 PCOS 2D 3D 2D 4D 2 2D 3D 2D 3D < 2D 4D < 3D 4D < 2D 5D < 4D 5D < 3D 5D 10 2 2 2D 4D x 珋 ± s PCOS n = 110 n = 192 n = 26 n = 328 10 n = 417 2D 3D 0. 8939 0. 0304 0. 8901 0. 0245 0. 9015 0. 0343 ΔΔ 0. 8923 0. 0275 0. 9330 2D 4D 0. 9526 0. 0455 # 0. 9416 0. 0377 0. 9539 0. 0419 0. 9460 0. 0411 0. 9563 2D 5D 1. 1204 0. 0815 # 1. 1821 0. 0815 1. 1730 0. 0661 1. 1884 0. 0808 1. 0877 3D 4D 1. 0657 0. 0342 1. 0579 0. 0321 1. 0582 0. 0276 1. 0603 0. 0327 1. 0277 3D 5D 1. 3470 0. 0865 # 1. 3281 0. 0854 1. 3014 0. 0625 1. 3321 0. 0847 1. 1772 4D 5D 1. 2639 0. 0680 1. 2554 0. 0698 1. 2300 0. 0532 1. 2563 0. 0682 1. 1552 2D 3D 0. 9000 0. 0315 0. 9051 0. 0323 0. 8992 0. 0392 0. 9028 0. 0326 0. 9115 2D 4D 0. 9661 0. 0496 # 0. 9759 0. 0457 0. 9488 0. 0503 ΔΔ 0. 9704 0. 0479 0. 9565 2D 5D 1. 2296 0. 0881 ## 1. 262 0. 0960 1. 1971 0. 0992 Δ 1. 2454 0. 0956 1. 0877 3D 4D 1. 0731 0. 0335 ## 1. 0781 0. 0294 1. 0551 0. 0288 Δ 1. 0746 0. 0313 1. 0445 3D 5D 1. 3662 0. 0855 # 1. 3937 0. 0929 1. 3303 0. 0781 Δ 1. 3793 0. 0911 1. 1960 4D 5D 1. 2729 0. 0654 # 1. 2924 0. 0736 1. 2607 0. 0617 ΔΔ 1. 2832 0. 0706 1. 1496 # P < 0. 05 ## P < 0. 01 P < 0. 05 P < 0. 01 PCOS Δ P < 0. 05 ΔΔ P < 0. 01 2. 3 4D 5D POF P- 2D 3D 2D 4D 3D 4D COS 4D 5D 3

866 34 3 Mean SD t P PCOS Mean SD t P Mean SD t P L23 - R23-0. 0062 0. 0313-2. 069 0. 041-0. 0150 0. 0344-6. 041 0. 000 0. 0023 0. 0351 0. 340 0. 736 L24 - R24-0. 01347 0. 0520-2. 716 0. 008-0. 0343 0. 0516-9. 210 0. 000 0. 0051 0. 0459 0. 568 0. 575 L25 - R25-0. 0259 0. 0948-2. 868 0. 005-0. 0795 0. 0998-11. 036 0. 000-0. 0242 0. 0877-1. 405 0. 172 L34 - R34-0. 0075 0. 0377-2. 077 0. 040-0. 0203 0. 0359-7. 816 0. 000 0. 0032 0. 0281 0. 573 0. 572 L35 - R35-0. 0192 0. 0875-2. 298 0. 023-0. 0656 0. 0868-10. 479 0. 000-0. 0289 0. 0814-1. 810 0. 082 L45 - R45-0. 0090 0. 0647-1. 464 0. 146-0. 0370 0. 0695-7. 379 0. 000-0. 0308 0. 0701-2. 237 0. 034 L23 - R23 L24 - R24 L25 - R25 L34 - R34 L35 - R35 L45 - R45 2D 3D 2D 4D 2D 5D 3D 4D 3D 5D 4D 5D 2. 4 PCOS > > PCOS 3 2D 3D 2D 4D > > PCOS 3D 4D 3D 5D 4D 5D > PCOS > 2D 5D P- COS > > 2D PCOS 2D 3D 2D 4D 7 11 5 3D 2D 4D 9 PCOS 2D 5D 12 13 2D 4D 3D 4D t = 2. 13 1. 981 P < 0. 05 2D 5D 3. 1 2D 5D 3D 5D 4D 5D t = 2. 22-2. 97-2. 55-2. 31 P < 0. 05 2D 3D PCOS PCOS POF 3D 5D 4D 5D 3D 4D PCOS t = 2. 54 2. 38 2. 54 P < 0. 05 P- 14 15 COS 2D 3D P- PCOS COS POF PCOS BMI 2D 3D 2D 4D 2D 5D 10 B 3. 2 3D 4D 3D 5D 4D 5D t = 2D 3D < 2D 2. 11 2. 81 3. 20 3. 77 3. 32 2. 10 P < 0. 05 4D < 3D 4D < 2D 5D < 4D 5D < 3D 5D 2. 5 2D 4D 10 2D 4D 2D 3D 2D 4D 2D 4D 25 75 2D 4D PCOS 2D 4D 1 2 PCOS PCOS χ 2 = 16. 31 12. 14 P < 0. 05 POF

9. 867 PCOS 46 2 142-157. 16 5 Manning JT Barley L Walton J et al The 2nd 4th 7 2D 4D PCOS 17 digit ratio sexual dimorphism population differences and reproductive success. evidence for sexually antagonistic genes J. Evol Hum Behav 2000 21 3 2D 4D PCOS 2D 4D 163-183. PCOS 2D 4D 6 Robin G Catteau - Jonard S Dewailly D et al. Polycystic vary syndrome A model of follicular excess J. POF 2D 4D 2D 3D Gynecol Obstet Fertil 2010 38 6 405-408. 2D 4D 7 Cattrall FR Vollenhoven BJ Weston GC. Anatomical PCOS evidence for in utero androgen exposure in women with 2D 3D 2D 4D polycystic ovary syndrome J. Fertil Steril 2005 84 2D 3D 2D 4D 6 1689-1692. 8 Revised 2003 consensus on diagnostic criteria and long - term health risks related to polycystic ovary syndrome P- 7 17 COS J. Hum Reprod 2004 19 1 41-47. 9 2D 5D 2D 3D 2D 4D PCOS J. 2008 2 267-271. 10 Manning JT Scutt D. Wilson J et al. The ratio of 3. 3 2nd to 4th digit length a predictor of sperm numbers and concentrations of testosterone luteinizing hormone and oestrogen J. Hum Reprod 1998 13 18 11 3000-3004. 11 Lujan ME Bloski TG Chizen DR et al Digit ratios 9 do not serve as anatomical evidence of prenatal androgen exposure in clinical phenotypes of polycystic ovary syndrome J. Hum Reprod 2010 25 1 204-211. 12. J. 2008 5 765-768. 13. J. 2008 4 359-363. 14 Kim CH Howles CM Lee HA. The effect of transdermal testosterone gel pretreatment on controlled ovarian stimulation and IVF outcome in low responders J. Fertil Steril 2011 5 2 679-683. 1 Breedlove SM Minireview Organizational hypothesis instances of the fingerpost J. Endocrinol 2010 51 9 4116-4122. 2 Manning JT Bundred PE. The ratio of 2nd to 4th digit length a new predictor of disease predisposition J. Med Hypoth 2000 54 5 855-857. 3 Abbott DH Zhou Rao Bird Ian M et al Fetal Programming of Adrenal Androgen Excess Lessons from a Nonhuman Primate Model of Polycystic Ovary Syndrome J. Endocr Dev 2008 13 145-158. 4 Zabuliene LJ Tutkuviene. Body composition and polycystic ovary syndrome J. Medicina Kaunas 2010 15 van der Stege JG Groen H van Zadelhoff SJ et al. Decreased androgen concentrations and diminished general and sexual well - being in women with premature ovarian failure J. Menopause 2008 15 1 23-31. 16 Nejad ES Saedi T Saedi S et al. Comparison of in vitro fertilisation success in patients with polycystic o- vary syndrome and tubal factor J. Gynecol Endocrinol 2011 27 2 117-120. 17 Wood S Vang E Manning J et al. The ratio of second to fourth digit length in azoospermic males undergoing surgical sperm retrieval predictive value for sperm retrieval and on subsequent fertilization and pregnancy rates in IVF /ICSI cycles J. J Androl

868 34 2003 24 6 871-877. 18 Honekopp J Watson S. Meta - analysis of digit ratio 2D 4D shows greater sex difference in the right hand J. Am J Hum Biol 2010 22 5 619-630. The Association between Digit Ratios and Ovarian Function ZHAO Jun - li LIU Li LIU Wei LI Feng - hua YUAN Ying - ying LI Cai - yan 1. Reproductive Center General Hospital of Ningxia Medical University Yinchuan 750004 2. Key Laboratory of Genetic and Reproduction Ningxia Hui Autonomous Region Yinchuan 750004 3. Key Lab. of Fertility Preservation and Maintenance Ministry of Education Yinchuan 750004 Abstract Objective To investigate the association between the digit ratios and infertility ovarain function among female patients in Ningxia region. Methods Fingers' length was measured twice using an electronic vernier callipe from photocopies of the ventral surface of the hand the mean value and were calculated for each finger of the right and left hand. Digit ratios were assessed among 110 females with regular menstrual cycle normal hormone profiles and without polycystic ovaries control 192 females with polycystic ovarian syndrome PCOS according to the 2003 Rotterdam criteria and 26 females with premature ovarian failure POF in patient population. Results The digit ratios showed the increasing trend from 2D 3D to 2D 4D 2D 5D 3D 5D 4D 5D in both hands. Decreasing trend of each digit ratio in right hand and increasing trend of 2D 3D 2D 4D in left hand from group PCOS to control to POF decreasing trend of 2D 5D from group PCOS to POF to control and 3D 5D 4D 5D from group PCOS to control to POF in left hand were found. Lower 2D 4D 3D 4D in left hand and higher 2D 5D 3D 5D 4D 5D in right hand were presented in PCOS than those in controls t = 2. 13 1. 981 2. 22 2. 97 2. 55 2. 31 P < 0. 05 3D 5D 4D 5D in left hand and 3D 4D in left hand showed significant difference between POF and controls t = 2. 54 2. 38 2. 54 P < 0. 05 compared to POF group PCOS had significant lower 2D 3D in left hand and higher 2D 4D 2D 5D 3D 4D 3D 5D 4D 5D in right hand t = - 2. 11 2. 81 3. 20 3. 77 3. 32 2. 10 P < 0. 05. Compared to left hand 2D 3D 2D 4D 2D 5D 3D 5D 4D 5D in PCOS group t = 6. 04 9. 21 11. 04 7. 82 10. 48 7. 38 P < 0. 01 2D 3D 2D 4D 2D 5D 3D 5D in control group t = 2. 07 2. 72 2. 87 2. 08 P < 0. 05 and 4D 5D in POF group t = 2. 24 P < 0. 05 in right hand were significant higher. The distribution of right hand 2D 4D was different among groups and between PCOS and controls χ 2 = 16. 31 12. 14 P < 0. 05 with higher proportion of lower 2D 4D in POF and higher one in PCOS group. Conclusion This finding implies that digit ratios may be associated with ovarian function in female patients. Lower digit ratios in right hand and higher 2D 3D 2D 4D in left hand and their verse trend may be associate with poorer ovarian function and infertility with higher ovarian function among female patients respectively. Key words digit ratios polycystic ovarian syndrome premature ovarian failure infertility ovarian function AMLC AMLC 40%