V o l. 20 N o. 8 1 9 9 9 8 CH EM ICAL JOU RNAL O F CH IN ESE UN IV ERS IT IES 1210 1217 [ ] D NA 3 (,, 430072) DNA, DNA. DNA DNA. DNA, DNA,, O 605 1953 W atson C rick [1 ] DNA, DNA,. DNA, DNA, DNA DNA. 60, DNA 2 (daunom ycin, DNM ), DNA DNA., DNA.,. DNA. DNA, DNA,,. DNA., DNA, DNA., DNA,. DNA DNA. 1 D NA D NA DNA DNA,., DNA DNA, DNA. 1. 1, DNA, : 1998212204. :. :,, 23,. 3 ( : 29773034, 39770220, 39370213) ( : 96J037).
N o. 8 : DNA 1211 : ; (1), DNA (2). 1. 1. 1. (42N 2 ) (TM PyP), DNA, 1. F ig. 1 Sturcture of M (TM Py-P) M = m etal ions., [2 ],., 5 2CG23 (C= ; G= ) [3 ], DNA [4 ]., DNA A T (A = ; T = ) [A ]n [ T ]n (n> 2) [5 ]., DNA., 2DNA,,., DNA, [6 ], [7 ] [8 ], DNA,.. 1. 1. 2 60 Ro senberg [9 ] (g ), [10, 11 ]. ( 2),., F ig. 2 Structures of cis-platin (A) and carboplatin (B) DNA DNA [12, 13 ]., H am b ley [14 ].,,. Sadler [15 ] ( ) cis2{p tc l [M e2n (CH 2 ) 2PPh22N, P ] [M e2n (CH 2) 2PPh22P ]}C l,, DNA G, A 2780. 1. 1. 3, R u, R h, Co DNA. R u, DNA [16, 17 ]. DNA DNA,., R u DNA [18 ], R u DNA
1212 V o l. 20,, DNA., Jacquet [19 ], R u (tap ) 2 (bpy) 2+ (tap = 1, 4, 5, 82 ; bpy= 2, 2 ) DNA N H 2,. Co (Phen) 2+ 2 (Phen= 1, 102 ) DNA (dsdna ), 1, 102 DNA (dsdna ). [20 ],, Co (Phen) 2+ 3 ds2 DNA ;.. 1. 2 D NA 1. 2. 1 (B leom ycin, BLM ),,. 3 ( 3) : N 2, DNA ; ; C2 DNA. BLM Fe Cu, DNA. BLM DNA ( ssdna ), F ig. 3 Structure of BLM dsdna. V anderw all [21 ], BLM DNA,. BLM DNA C2 DNA. BLM 2DNA [22 24 ]. M anderville [25 ] NM R Zn (g ) BLM d (CGCTA GCG) 2, BLM 2DNA DNA. BLM, DNA,.,,.,.. 1. 2. 2, (A driam ycin, ADM ) (DNM ), 4. (N ogalam ycin, N g) A, 3. ADM, : ADM DNA F ig. 4 Structures of D NM and ADM
N o. 8 : DNA 1213 ( ) DNA [26 ] ; ADM, [27 ]. W einer [28 ] (E lectron Param agnetic R esonance, EPR ) ADM dsdna ssdna trna, ADM, OH, Schu ster [29 ],,,,. F rederick [26 ], DNM ADM C14, DNM gadm 2DNA.,.,.,, ADM, DNA, (, ). 1. 2. 3,, DNA,. DNA ss2 dsdna. (N CS Ch rom ) ( 5), 1 1. [30 ], N CS Ch rom ( 22N 2 m ethylfuco sam ine, NM F ) T A N PH (naph thoate) 5 2CT g5 2A G, ( T etrahy2 dro indecene, TH I) dsdna. F ig. 5 Structure of NCS chrom D ynem ycin A, Calicheam icin, E speram icin A C1027 [31, 32 ]. 1. 2. 4 DNA, C (M itom ycin C, M C),, 6., M C DNA., M C DNA,, M C DNA, [33 ]. F ig. 6 Structure of M itomyc in [34 ], M C DNA, 5 CG 5 GG.
1214 V o l. 20 2 D NA DNA, DNA. 2. 1 (1), DNA.,., TM PyP DNA GC. (2),. Π Π Π2Π. DNA. GC [35 ],, DNA,,, DNA. DNA DNA, DNA ;, DNA. (3), DNA DNA. A T [36 ], A N 3 T O 2. Hoech st33258 DNA ( ), A T [37, 38 ].,, Hoogsteen DNA,., ;,,. 2. 2, DNA DNA. duocarm ycin ( 7), DNA A T, A N 3 [39, 40 ]. P t DNA F ig. 7 Structure of (+ ) -duocarmyc in [d (GpG) ] N 7, DNA,. BLM DNA, DNA 5 2GC23, DNA,., DNA DNA
N o. 8 : DNA 1215,. 3 DNA,,.. 3. 1 DNA [41 ]. DNA DNA, DNA ; DNA,,. 3. 2 DNA, 260 nm. DNA, DNA, DNA,. g DNA. DNA., [42 ]. (LD ),, DNA DNA [43 ]. (CD ), DNA 260 nm ; CD, DNA CD,. (RR ) (TR 3 ) DNA [4, 5, 44 ].,, DNA [45 ]. 3. 3 DNA,,, DNA, g, [20, 46 48 ]. DNA,. DNA [20, 47 ], DNA. 3 15 Λg DNA., DNA,. C 60, DNA, DNA., : NM R DNA DNA. DNA, X, DNA
1216 V o l. 20,, DNA DNA., DNA gdna,,. 4, 40 DNA.,,, DNA,.. (1) DNA,, DNA DNA. (2), DNA.. (3) DNA,,. (4) DNA. (5) DNA, DNA., DNA,,. DNA DNA,. 1 CAO Kai2M ing ( ), L IB i2yu ( ), PEN G Ze2Guo ( ). A n Introduction to the Chem istry of N ucleic A cids( ), Shanghai: Fudan U niversity P ress, 1991: 1 2 M astruzzo A., W o isard D. D. F., R izzrell E. et a l.. Pho tochem istry and Pho tobio logy, 1996, 60: 316 3 M arzilli L. G., Banville D. L., Zon G. et a l.. J. Am. Chem. Soc., 1986, 108: 4 188 4 W heeler G. V., Ch insky L., M iskovsky P. et a l.. J. B iomo lecular Structure & D ynam ics, 1995, 13: 399 5 W heeler G. V., L aigle A., Ch insky L.. J. B iomo lecular Structure & D ynam ics, 1997, 15: 107 6 P raseuth K., Gaudem er A., V erlhac J. B. et a l.. Pho tochem istry and Pho tobio logy, 1986, 44: 717 7 RodriguezM., Kodadek T., To rres M. et a l.. B ioconjugate Chem., 1990, 1: 123 8 W are B. W., Sko robagaty A., D abrow iak J. C.. B iochem stry, 1986, 25: 6 875 9 Ro senberg B., van Camp L., T ro sko J. E. et a l.. N ature, 1969, 222: 385 10 N ararro J. A. R., Salas J. M., Rom era M. A. et a l.. J. M ed. Chem., 1998, 41: 32 11 T akahara P. M., Ro senzw eig A. C., F rederick C. A.. N ature, 1995, 19: 49 12 B row n S. J., Kellett P. J., L ippard S. J.. Science, 1993, 261: 603 13 Reedijk J.. Chem. Comm un., 1996: 801 14 H am bley T. W.. Coo rdination Chem istry Review s, 1997, 166: 181 15 H abtem ariam A., Sadler P. J.. Chem. Comm un., 1996: 1 785 16 Pyle A. M., Barton J. K.. P rog. Ino rg. Chem., 1990, 38: 413 17 L inco ln P., T uite E., N o rden B.. J. Am. Chem. Soc., 1997, 119: 1 454
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