725 30 30 30 (FA [(0.296 ± 0.030(0.302 ± 0.030(0.326 ± 0.026P < 0.05] [(0.560 ± 0.031(0.568 ± 0.025(0.581 ± 0.028P < 0.05] (P > 0.05 R749.3;R445 A MRI fiber tracking study on the white matter integrity in schizophrenia and their siblings. HAO Yihui GAO Jinsong ZHANG Huiran OUYANG Xuan LIU Haihong LI Youhui SONG Xueqin LIU Zhening. Department of Psychiatry of the First Affiliated Hospital of Zhengzhou University Zhengzhou 450052 China. Tel:13598009598. Abstract Objective To identify whether the integrity of brain white matter is abnormal in schizophrenia patients and their unaffected siblings. Methods White matter density was compared among schizophrenic patients their unaffected siblings and healthy controls using voxel-based morphometry and the brain regions showing significant difference among groups were defined as the region of interest (ROI. Fiber tracking was then used to reconstruct the white matter fiber within ROI and then the fractional anisotropy (FA was compared among three groups. Results Both schizophrenia patients and their siblings showed significant reduction of FA in the left prefrontal cortex (PFC and genu of corpus callosum as compared healthy controls [(0.296 ± 0.030 (0.302 ± 0.030 (0.326 ± 0.026 P < 0.05; (0.560 ± 0.031 (0.568 ± 0.025 (0.581 ± 0.028 (P < 0.05. While no significant difference was found between the patient group and the sibling group (P > 0.05. Conclusions The disruption of white matter integrity in the left PFC and genu of the corpus callosum might be the susceptibility biological marker for schizophrenia. Key words Schizophrenia Unaffected siblings Fiber tracking White matter integrity [2] DTI 9 [1] (diffusion tensor imaging DTI 973 ( ( :8107109230971058 [3-6] :2007CB512300 ( 450052 DTI * (E-mail: zheningliu@yahoo.com.cn
726 Chin J Nerv Ment Dis Vol.37 No.12 December 2011 1 1.1 2007 2 T1 2009 7 (three-dimentional gradient-e- cho sequence :TR / TE :1 (DSM- ; = 12.1 / 4.2 ms (FOV 24 cm 24 cm 2 18 ~ 45 ;3 (positive 256 256 1.8 mm 172 and negative syndrom scale PANSS 60 ; 4 9 ;5 ;6 30 16 14 18 ~ 41 (24.39 ± 5.23 1 ~ 1 000 s / mm 2 96 (20.15 ± 11.85 9 ~ (b = 0 : TR = 12 000 ms; TE = 105 16 (12.50 ± 2.16 :1 ms; matrix = 128 128; FOV = 24 cm 24 cm;nex ;2 5min ;3 = 5 = 4 mm = 0 mm 30 DSM- ;4 : :1 MRIcro DICOM ;2 18 ~ 45 ;3 9 ANALYZE ;4 1 1 (statistical parameter mapping 2 SPM2 30 ANALYZE 19 11 18 ~ 39 (25.37 ± 7.06 9 ~ 18 DSM- ; 4 2 2 2 mm 3 ( ; : :1 18 ~ 45 ; 2 9 ;3 ; 30 18 12 18 ~ 41 (25.00 ± 6.22 9 ~ 18 (13.77 ± 2.42 3 ( 掊 2 = 0.64 P > 0.05 (F = 0.04 P > 0.05 (F = 2.14 P > 0.05 DTI [7] 1.2 (GE signa 1.5T Twinspeed Milwaukee 2 16min10s 13 b = (Montreal Neurology Institute MNI (n = 152 (12.87 ± 2.70 :1 ; 2 5min ; 3 ( FWHM 8 mm FWHM Gaussian kernel 1.2.3 VBM 1.2.1 PANSS DTI 3 100 1.2.2 (P < 0.001 > 100 1.5T MATLAB6.5 XJVIEW
727 MRIcro(1.39 Build 1 http: / / www.mricro.com (region of interest ROIs 1 ROI 1.2.4 1 MRIcro Kanaan ROI DICOM ANALYZE b0 ~ b13 14 FA ROI FA (b0 b1 ~ b13 13 ; 2 MABLAB6.5 SPM2 14 SPM2 ROI MNI 2 2 2 mm 3 ; 3 14 MedINRIA (http: / / www -sop.inria.fr / asclepios / software / MedINRIA FA ; 2 4 ROIs ( 10 mm FA 0.2 FA 1.3 SPSS 12.0 3 VBM ( A B (least significant difference LSD 3 FA α = 0.05 2 : 3 FA [(0.296 ± 0.030 (0.302 ± 0.030 (0.326 ± 0.026 F = 4.31 P < 0.05] 2 FA (P = 0.006; P = 0.035 (P > 0.05 3 FA [(0.560 ± 0.031(0.568 ± 0.025(0.581 ± 0.028F = 3.13P < 0.05]; FA (P = 0.025;P = 0.045 (P > 0.05 3A 3B A B 1 3 3 (FA A ;B * LSD P < 0.05 A 3 FA B
728 Chin J Nerv Ment Dis Vol.37 No.12 December 2011 MRI (vertical displacement FA Camchong [4] DTI ( [3] Knochel [14] FA [4] Price [8] [15] ROI FA FA Rotarska- Jagiela [9] 50% FA FA Kubicki [10] 32 DTI ROI FA FA FA FA [1] Sadock BJ SVA Schizophrenia. In: Sadock BJ Sadock VA eds. Kaplan and Sadock's synopsis of psychiatry: behavioral sciences / clinical psychiatry. (10th ed. [J]. New York:Wolgters Kluwer and Lippincott Williams & Wilkins 2007:467. FA ; FA [2] Le BD Mangin JF Poupon C et al. Diffusion tensor imaging: P 0.05 concepts and applications[j]. J. Magn Reson Imaging 200113 (4: 534-546. [3] Hoptman [6] 201036 (11: FA 641-644. ;Munoz Maniega [11] [4] Camchong J Lim KO Sponheim SR et al. Frontal white matter FA integrity as an endophenotype for schizophrenia: diffusion tensor ;Karlsgodt [12] imaging in monozygotic twins and patients' nonpsychotic relatives [J]. Front Hum Neurosci 20093:35. - - [5] Ellison-Wright I and Bullmore E. Meta-analysis of diffusion FA tensor imaging studies in schizophrenia[j]. Schizophr Res 2009 108(1-3:3-10. FA Narr [13] [6] Hoptman MJ Nierenberg J Bertisch HC et al. A DTI study. [J].
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