Progress on oral colon specific drug delivery system

1 2 1 2 1 2 1 2 1 2 1 300193 2 300193 R944 A 1003-3734 2015 04-0390 - 05 Progress on oral colon specific drug delivery system ZHOU Jie 1 2 ZHU Xiao-ning 1 2 ZHANG Yi 1 2 ZHOU Xin 1 2 CUI Yuan-lu 1 2 1 Reasearch Center of Traditional Chinese Medicine Tianjin University of Chinese Medicine Tianjin 300193 China 2 Tianjin State Key Laboratory of Modern Chinese Medicine Tianjin 300193 China Abstract Oral colon specific drug delivery system has gained more attention from investigators in recent years since it can improve local drug concentration and reduce dosage and side effects. The design principle preparation technology and in vitro / vivo evaluation methods of oral colon specific drug delivery system were summarized in this paper to provide theoretical basis and reference for the development of oral colon specific drug delivery system. Key words colon specific drug delivery system preparation technology evlaution methods 20 90 1 1 6 2 2 3-5 7 ph 2012ZX09304007 18722122605 E-mail rhea1373879236@ 163. com 022 59596170 E-mail cuiyl @ tju. edu. cn 390 ph

1. 1 ph 16 HPMC ph EC HPMC γ- ph ph 5-5-ASA ph 1. 3 Gao 8 CPVA-g-PSSS MTZ ph ph = 1 Jeong 17 ph = 7. 4 EC HPMC 9 HPMCAS 10 ph -Eudragit100 PEG EC EC ph ph 18 Kovačič 11 ph 1. 2 McLeod 20 - HPMC Time Clock 12 5-ASA 21 Wilding 13-14 1. 4 Stella 19 1951 5-ASA Amal 22 Wu 15 HPMC 5- L- α- β- HPMC Zhiz 23 β- MTZ MTZ 391

9. 5% 43. 6% Maestrelli 30 24 h 100% Riberio 31 / 24 β- Jose 32 /ph β- 25 Eudragit S-100 3 β- ph = 6. 8 33 34 35 36 Miloslava 3 26 3 27 37 / Jerry 38 Dhawan 28 ph Dai 39 2 1. 5 2. 1 ph Mirela 29 ph Eudragit FS 30 D ph / ph 392

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