32 6 2013 12 Chinese Journal of Biomedical Engineering Vol. 32 No. 6 December 2013 1 2 1 2* 1 325035 2 518057-3 D R318. 08 A 0258-8021 2013 06-0723-08 Progresses in Artificial Small-Diameter Blood Vessel Grafts and their Preparation Methods WANG Shuai-Yan 1 LAI Chen 2 XI Ting-Fei 1 2* 1 School of Medical Laboratory & Life Science Wenzhou Medical College Wenzhou 325035 China 2 Biomedical Engineering Research Center Shenzhen Institute of Peking University Shenzhen 518057 China Abstract Vascular transplantation is one of the main methods in the treatment of cardiovascular diseases. The development of small caliber artificial blood vessel also becomes the focus in the nearly 10 years. This paper introduces the research progress from the aspects of materials and methods of the preparation of small diameter artificial blood vessels in recent years. First we describe the synthetic materials and natural biological materials then introduce the research progress dip - leaching method coagulation method decellularization organization composition electrostatic spinning method rotating exposure method tissue engineering blood vessel scaffold method and 3D rapid prototyping technology. It presents the characteristics of different materials and preparation methods for uses in small caliber artificial blood vessels and provides certain reference for further developments of ideal artificial blood vessels as well as its prospects. Key words small caliber artificial blood vessels blood vessels material preparation method 1898 Gluck doi 10. 3969 /j. issn. 0258-8021. 2013. 06. 012 2013-04-10 2013-10-14 973 2012CB933600 * E-mail xitingfei@ pku. edu. cn
724 32 6 mm ~ 500 MPa ~ 2 MPa 7 Golden 1 4 mm eptfe 8 60μm Kohler eptfe 9 2 1 10-11 W. L. Gore&Associates Gore-Tex PGA PHA polyurethane PU < 6 mm 2 3-4 Mori 5 38. 9% 5 1. 1 dacron 1. 5 mm PU 13 Grasl 140 mm 2. 1 mm 80 ± 4 μm PU 2-14 Taite YIGSR NO 6 Blumenberg 15 polyglycolic acido PGA eptfe 12 3 expanded polytetrafluroethylene eptfe Gaoguoliang PGA 16
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