CURATIVE EFFECTS OF THE FRUITS OF ARONIA MELANOCARPA

ARONIA MELANOCARPA., CURATIVE EFFECTS OF THE FRUITS OF ARONIA MELANOCARPA M. Boncheva Chair of General Medicine nd Clinical Laboratory, Medical University Varna. Aronia melanocarpa, -. Aronia melanocarpa. (, ). Aronia melanocarpa,,,. Aronia melanocarpa, 5 -. 250 10 -.,, -,,... Aronia melanocarpa, -,. : Aronia melanocarpa,, Summary. Aronia melanocarpa is a plant whose fruits are known to stimulate the healing effects in humans and animals. Bulgaria is a country with very favorable climatic conditions and many areas with suitable soil and irrigation for the cultivation of Aronia melanocarpa. The presence in Bulgaria of EU-certified bioproducers of fruit and chokeberry products (juice, fruit wine) is the reason for this review. The aim is to highlight from the standpoint of modern medical science the "magic" effect, following the intake of fruits of Aronia melanocarpa, as well as the EU-certified Bulgarian bioproducts prepared from these fruits. An analysis of the chemical composition of the juice from the fruits of Aronia melanocarpa has shown that it is 5 times richer in anthocyanins than other similar "black" fruits. In over 250 publications for the last 10 years, biological and pharmacological activities of the anthocyanins, contained in the juice, have been studied. Antioxidant, antimutagenic, cardioprotective, hepatoprotective and antidiabetic effects have been established. The antimicrobial action and protection against radiation have been studied. There is no fixed therapeutic dose. Regular use of the fruit juice from Aronia melanocarpa in the daily diet of humans, combined with healthy lifestyle habits, have a preventive effect on contemporary socially significant diseases. Key words: Aronia melanocarpa, anthocyanins, antioxidant effects, 14, 2012, 3 39

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,,,,, [8].,. - (. 1),., Aronia melanocarpa,., -, [8]. 1. Aronia melanocarpa 65-72% 0,44% 1,1-1,4% 0,5-0,6% ( ) 2000-8000 mg/100 g 10-18% 0,6-0,7% :,, :, Zn, Na, Ca, Mg, Fe : 1, 2, 6, 9,,,,,, - -, ( mg%) - (μg%) : -, 40 :,, ( 17) % 0,14%, mg% ( mg%) 65 38,6 62,2 17,4 12,2 14,7 9,3 (μg%) 4000 500 -.., -. -,,. - -. 4- -, - (, - ). -,., 14, 2012, 3 41

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: - (SOD),, - (GSP). -,., -, ( ) - -., [10]. -,, -. Q10,, L-, L-, -. - -, -, - -.,, ( -, ), -,, -,. -, ROS - ( -, - Parkinson, Alzheimer); - ;, -,,,,, -,,,, -,, -. -, - [20]... - -,, -. Hartman, -. 1972.. - -., -, Aronia melanocarpa, in vitro, in vivo. TBARS thiobarbituric acid reactive substances,, -.,, - ( ), - TBARS.,,, TBARS,, - -., - ( - Streptozotocin),, - -,,, TBARS. Streptozotocin, -.,,, [8, 16]., -, -, -,. (,,, ) -, -, - -, [7, 21]. -,., 14, 2012, 3 43

, [12]. e - ( ) 30-, [11]. - -,, LDL - - [8]., -,. -,,. - TBARS, -, [8, 15]. 44., [1, 8].,., - -,, - - [10, 20]. - - in vitro in vivo,. -,, -,. -.,, -,. - in vivo [8]., - 400 mg/kg, - - 2-3 μg/ml (4-6 μ ) 15. 1,2%., -3- (C3G), 30-0,3 μ /L, 15 -.,. -, C3G 320 mg/kg, 3,5 μ /L [8].,, C3G 2,7 mg/kg - 30. - - -. -. -, 63, - 720 mg - 71. 133. - 4 0,04%. per os. - ( ), -,. -,,, -,, - - [8]., -. - in vitro, in vivo [7, 16, 21]. Aronia melanocarpa in vitro. -.. Aronia melanocarpa

,, -.. -2. -., -., -, -. -2, -,, [16]. - -., - -2, -. - - 4-2 G2/M. (tumor suppressor carcinoembrionic antigen-related cell adhesion molecule 1), -. [2, 4, 9].. ( )..,, -, -, -.,, -,, -,, - -., -, [21]. in vitro - 17 - -2.,, -., -, - -., -, [4, 22]. -. L1210. DNA II. - L1210 - in vitro. - 90% L1210 - [8]., HL60. HL60/VINC HL60/DOX,. - - - [8]. -. - n-nitrosamine,.,, - n-nitrosamine,, [17].,. -, -.,.. [10]. -, 14, 2012, 3 45

,. 30-,. Chol, LDL-Chol, HDL-Chol TG. - Chol, LDL-Chol, - HDL-Chol [8, 19]. Chol TG, [8].,,. -. -.,, 6. - Chol, LDL-Chol TG HDL-Chol, [15]. - endothelin 1 [8]. -,, - 6. - LDL-Chol, 8-. - - LDL-Chol 8-. - [8]., - Aronia melanocarpa. - - [8]. -.. 6 8 - [8, 15]. -. -. - -. -,, - [8, 12]. - -. -, - CCL4.. -, [8]., - : - [17], [8]. -, -,. - - [18].,,. 2, 2,. -,,. -, - 2. - [3, 6, 13].. -, 6, 40-50% [8]. - PC12 L929 [8]. - 46.. Aronia melanocarpa

, 2, 200 ml - 3, -,, [14].. -, -. 4 - : - ; - - n- - ; ; (AGES). -. Brownl, ( ) - -. -, -, - -,, - - [3, 6, 13]. - -, ROS. -,.,. -. -. [8, 21]. in vitro., Staphylococcus aureus Escherichia coli., [8]., Staphylococcus Salmonella [7, 8]. -,. -, -, [8]. -,, -, - [8]., -, CD4 CD8., -, - - [8]., - Aronia melanocarpa, : 1. -. 2. - Aronia melanocarpa. 3., - 5,,,, -,,,. 4. -,,. 5. - Aronia melanocarpa, -. 6.. - - -, 14, 2012, 3 47

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