Supplementary data to: The mir-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2

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Supplementary data to: The mir-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB and ZEB2 Sun-Mi Park, Arti B. Gaur 3, Ernst Lengyel 2 and Marcus E. Peter,4 The Ben May Department for Cancer Research, 2 Department of Obstetrics and Gynecology/Section of Gynecologic Oncology, The University of Chicago and 3 Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, New Hampshire.

Supplementary figure legends: 2 Figure S. Expression of 207 different mirnas in the NCI60 cells ranked according to expression in either epithelial or mesenchymal cell lines. P-values are the result of a two-sample t-test analysis. High expression is indicated in red and low expression in blue. Fold change (log2) is indicated. Figure S2. Comparison of the ratio of E-cadherin/Vimentin protein expression with expression of either mir-4, mir-200a, mir-200b or mir-200c in the NCI60 cells. Pearson correlation coefficients (r) and p-values (p) are reported. Figure S3. (A) Normalized ΔCTs of the expression of the functional cluster mir-200a/mir-4 mirnas were added and plotted against the sum of the ΔCTs of mir-200b and mir-200c. (B) Normalized ΔCTs of the expression of the genetic cluster mir-200a and mir-200b mirnas were added and plotted against the sum of the ΔCTs of mir-200c and mir-4. Residual variances (R 2 ) are reported. Figure S4. Effects of only 5 nm of mir-200 on MDA-MB-23 cells. Cells were transfected with either 5 nm scrambled oligo (S) or a mixture of 2.5 nm mir-200a and 2.5 nm mir-200c and after 3 (D3) or 6 days (D6) expression of E-cadherin, ZEB and ZEB2 mrna was determined using real-time PCR. Figure S5. (A) Analysis of the expression of let-7d and mir-200c in 59 of the NCI60 cells. In the left half, the expression of let-7d in the Type I and Type II cells previously identified among the NCI60 cells (Algeciras-Schimnich et al. 2003) and the SC and SC2 cell lines among the 59 NCI60 cells are shown. In the right half the expression of mir-200c in the same cells is shown. (B) Comparison of the ratio of E-cadherin/Vimentin protein expression with expression of let-7d in the NCI60 cells. Cells with either high E-cadherin and no Vimentin (I), E- cadherin/vimentin ratio of around one (II) and with high Vimentin and low E-cadherin expression (III) are labeled with a stippled oval. (C) Comparison of the ratio of E- cadherin/vimentin protein expression with expression of mir-200c in the NCI60 cells. Group I, group II and group III cells are labeled. SC and SC2 cells within the epithelial group I are labeled in blue and red, respectively. Residual variances (R 2 ) are given. References Algeciras-Schimnich, A., E.M. Pietras, B.C. Barnhart, P. Legembre, S. Vijayan, S.L. Holbeck, and M.E. Peter. 2003. Two CD95 tumor classes with different sensitivities to antitumor drugs. Proc Natl Acad Sci U S A 00: 445-50.

Figure S mirna ID K562 HL60TB MOLT4 CCRFCEM SW620 IGROV NCI-H522 SR OVCAR5 NCI-H23 CAKI ADR-RES PC3 BT549 ACHN SN2 OVCAR8 HOP62 LOXIMVI SNB9 SF295 MDAMB435 TK0 MDAMB23 U25 SKMEL2 786-0 M4 A498 SF268 SNB75 UACC62 RXF393 SKMEL28 SF539 HS578 HOP92 OVCAR4 NCI-H322M HCC2998 HT29 T47D COLO205 HCT5 MCF7 KM2 OVCAR3 HCT6 epithelial mesenchymal 0-0 p-value 2 0-20 hsa-mir-200c hsa-mir-4 hsa-mir-200b hsa-mir-200a hsa-mir-203 hsa-mir-55 hsa-mir-40 hsa-mir-46 hsa-mir-204 hsa-mir-05 hsa-mir-375 hsa-mir-299 hsa-mir-37 hsa-mir-32 hsa-mir-2 hsa-mir-34 hsa-mir-27 hsa-mir-223 hsa-mir-22 hsa-mir-34a hsa-mir-97 hsa-mir-25b hsa-mir-23 hsa-mir-8b hsa-mir-30a-3p hsa-mir-95 hsa-mir-7 hsa-mir-00 hsa-mir-29a hsa-mir-99b hsa-mir-96b hsa-mir-205 hsa-mir-28 hsa-mir-94 hsa-let-7a hsa-mir-32 hsa-mir-30e-3p hsa-mir-96 hsa-mir-99a hsa-mir-92 hsa-mir-27a hsa-mir-424 hsa-mir-92 hsa-mir-2 hsa-mir-8a hsa-mir-30a-5p hsa-mir-32 hsa-mir-35b hsa-mir-25 hsa-mir-30c hsa-mir-48a hsa-mir-07 hsa-mir-24 hsa-mir-30an hsa-mir-39 hsa-mir-20 hsa-mir-324-5p hsa-mir-335 hsa-mir-28b hsa-mir-30a hsa-mir-53 hsa-mir-35a hsa-mir-9 hsa-mir-302b hsa-mir-92 hsa-mir-222 hsa-let-7d hsa-mir-22 hsa-mir-24a hsa-mir-99a hsa-mir-372 hsa-mir-5 hsa-mir-98 hsa-mir-302d hsa-mir-342 hsa-mir-52 hsa-mir-345 hsa-mir-37 hsa-mir-302a hsa-mir-86 hsa-mir-26 hsa-mir-24b hsa-mir-30b hsa-mir-302c hsa-mir-373 hsa-mir-338 hsa-mir-48b hsa-mir-28a hsa-mir-325 hsa-mir-33b hsa-mir-339 hsa-mir-42-5p hsa-mir-29c hsa-mir-9 hsa-mir-425 hsa-mir-82 hsa-mir-28 hsa-let-7f hsa-mir-330 hsa-mir-30b hsa-mir-24 hsa-mir-23a hsa-mir-36 hsa-mir-29 hsa-mir-326 hsa-mir-47 hsa-mir-30e hsa-mir-99b hsa-mir-54 hsa-mir- hsa-mir-99-s hsa-mir-38 hsa-mir-0b hsa-mir-368 hsa-mir-380-3p hsa-mir-384 hsa-mir-224 hsa-mir-36 hsa-mir-380-5p hsa-mir-377 hsa-mir-8c hsa-mir-383 hsa-mir-38 hsa-mir-422a hsa-mir-33 hsa-mir-337 hsa-mir-26 hsa-mir-04 hsa-mir-93 hsa-mir-29 hsa-mir-22a hsa-mir-44 hsa-mir-98 hsa-mir-208 hsa-mir-27 hsa-mir-220 hsa-mir-369 hsa-mir-89 hsa-let-7i hsa-mir-23b hsa-mir-43 hsa-mir-03 hsa-mir-27b hsa-mir-88 hsa-mir-26a hsa-mir-33 hsa-mir-9a hsa-mir-45 hsa-let-7g hsa-mir-9b hsa-mir-84 hsa-mir-29b hsa-mir-367 hsa-mir-296 hsa-mir-346 hsa-mir-340 hsa-mir-20n hsa-mir-30 hsa-mir-6 hsa-mir-7-5p hsa-mir-5a hsa-mir-422b hsa-mir-324-3p hsa-mir-374 hsa-mir-95 hsa-mir-328 hsa-mir-423 hsa-mir-87 hsa-mir-0a hsa-mir-42-3p hsa-mir-85 hsa-mir-33a hsa-mir-90 hsa-mir-20 hsa-mir-49 hsa-mir-83 hsa-mir-382 hsa-mir-5b hsa-mir-25 hsa-mir-93 hsa-mir-26b hsa-mir-320 hsa-mir-34b hsa-mir-376a hsa-mir-7-3p hsa-mir-0 hsa-mir-25a hsa-mir-06a hsa-mir-30d hsa-mir-34c hsa-mir-370 hsa-mir-50 hsa-mir-206 hsa-mir-8 hsa-mir-379 hsa-mir-3 hsa-let-7e hsa-mir-378 hsa-mir-22 hsa-mir-06b hsa-mir-96a hsa-mir-323 hsa-let-7c hsa-let-7b hsa-mir-08 5 7 9 23 25 3 35 43 5 55 63 73 75 8 95 05 07 3 5 23 37 45 53 65 73 77 79 8 87 95 7 27 29 37 39 47 57 59 67 69 79 89 97 99 09 9 27 3 39 6 69 9 99-5 -4-3 -2-0 2 3 4 5

Figure S2 0 6 0 5 0 4 0 3 0 2 0 6 0 5 0 4 0 3 0 2 0-0 - E-cadherin/Vimentin 0-2 0-3 0-4 0-5 0 6 0 5 0 4 0 3 R=0.6500 p<0.000 0 20 40 60 80 00 mir-4 0-2 0-3 0-4 0-5 0 6 0 5 0 4 0 3 R=0.48039 p=0.000 0 20 40 60 80 00 mir-200a 0 2 0 2 0-0 - 0-2 0-2 0-3 0-4 R=0.44980 p=0.0004 0-3 0-4 R=0.563 p<0.000 0-5 0 20 40 60 80 00 mir-200b 0-5 0 20 40 60 80 00 mir-200c

Figure S3 A 0000 000 mir-200a + mir-4 (ΔCTs) 00 0 B R 2 = 0.9573 0 0 00 000 0000 mir-200b + mr-200c (ΔCTs) 0000 000 mir-200a + mir-200b (ΔCTs) 00 0 R 2 = 0.7599 0 0 00 000 0000 mir-200c + mir-4 (ΔCTs)

Figure S4 25 D3 D6.2 D3 D6 D3 D6 20.0 Fold change 5 0 5 0.8 0.6 0.4 0.2 0 S 200a/c S 200a/c 0 S 200a/c S 200a/c S 200a/c S 200a/c E-cadherin ZEB ZEB2

A let-7d mir-200c p=0.0005 p=0.0025 p=0.06 p=0.0036 Figure S5 00 % of highest expression 80 60 40 20 B E-cadherin/Vimentin 0 6 0 5 0 4 0 3 0 2 0-0 -2 0 I II 2 I II 2 Type supercluster Type supercluster II 0-3 III 0-4 0-5 0 20 40 60 80 00 let-7d I R 2 =0.08 C 0 6 OVCAR4 0 5 0 4 0 3 0 2 0-0 -2 0-3 0-4 0-5 T47D OVCAR3 III COLO205 HT29 II DU45 H322M HCC2998 HCT5 MCF7 HCT6 0 20 40 60 80 00 mir-200c I KM2 R 2 =0.656

Table S: Genes downregulated >0.5 in MBA-MD-23 cells transfected with either mir-200a or mir-200c mir-200a vs scr mir-200c vs scr TargetScan TargetRank Gene log2 change log2 change mir-4/200a mir-200b,c/429 mir-200a mir-200c Descriptions ICEBERG -3.2-2.6 gb:nm_0257. /DB_XREF=gi:0954342 /GEN=ICEBERG / QKI -0.7 -.3 X X X X gb:al0378 /DB_XREF=gi:4038570 /FEA=FLmRNA /CNT= LOX -0.3 -.3 X X gb:l6895 /DB_XREF=gi:292923 /FEA=DNA /CNT=3 /TID=H WIPF -0.4-0.9 X X X X gb:aw058622 /DB_XREF=gi:593426 /DB_XREF=wy59c0.x LHFP -0.4-0.9 X X X gb:nm_005780. /DB_XREF=gi:503864 /GEN=LHFP /FEA= Unknown -0.3-0.9 gb:af34802. /DB_XREF=gi:486836 /FEA=FLmRNA /CNT ZEB -0.5-0.8 X X X X gb:ai37366 /DB_XREF=gi:453032 /DB_XREF=qz3b0.x Unknown -0.3-0.8 Cluster Incl. U79256:Human clone 2379 mrna sequence /c Unknown -0.6-0.8 gb:be644809 /DB_XREF=gi:996920 /DB_XREF=7e57e09.x Unknown -0.4-0.8 gb:al33706 /DB_XREF=gi:660894 /DB_XREF=DKFZp76 APS2-0.2-0.7 X X gb:af25295. /DB_XREF=gi:200573 /FEA=FLmRNA /CN ZEB () -0.4-0.7 X X X X gb:ai80674 /DB_XREF=gi:5392740 /DB_XREF=wf06h03.x RPS6-0.4-0.7 gb:aa42942 /DB_XREF=gi:72320 /DB_XREF=zl43c04.s TAXBP -0.2-0.7 gb:al047908 /DB_XREF=gi:4728096 /DB_XREF=DKFZp586 Unknown -0.8-0.7 gb:av703394 /DB_XREF=gi:072072 /DB_XREF=AV70339 Unknown -0.7-0.7 gb:aw93 /DB_XREF=gi:6087697 /DB_XREF=xd89b09.x ZEB2-0.3-0.7 X X X X gb:nm_04795. /DB_XREF=gi:766283 /GEN=ZFHXB /FE PPAP2B -0.3-0.7 X X gb:aa628586 /DB_XREF=gi:2540973 /DB_XREF=af39f2.s Unknown -0.4-0.6 gb:nm_02455. /DB_XREF=gi:337574 /GEN=FLJ2432 / Unknown -0.3-0.6 gb:bf572868 /DB_XREF=gi:646580 /DB_XREF=60207944 Unknown -0.4-0.6 gb:al04976 /DB_XREF=gi:4808226 /FEA=FLmRNA /CNT=8 ATP2C -0.3-0.6 gb:af22598. /DB_XREF=gi:702496 /GEN=ATP2C /FEA= Unknown -0.4-0.6 gb:aa97899 /DB_XREF=gi:3057789 /DB_XREF=ol76e05.s Unknown -0.5-0.6 gb:h95263 /DB_XREF=gi:02896 /DB_XREF=yu20e04.s /C Unknown -0.4-0.6 gb:al05099. /DB_XREF=gi:4884438 /FEA=mRNA /CNT=2 Unknown -0.3-0.6 gb:nm_022753. /DB_XREF=gi:223248 /GEN=FLJ2903 / Unknown -0.2-0.6 gb:nm_0283. /DB_XREF=gi:0880976 /GEN=LOC57826 PCDH9-0.5-0.6 X X gb:ai52425 /DB_XREF=gi:4438260 /DB_XREF=th09d.x ALS2CR2-0.4-0.6 gb:ab038950. /DB_XREF=gi:2862479 /GEN=ALS2CR2 /FE TRIP8-0.3-0.6 gb:bf002296 /DB_XREF=gi:070257 /DB_XREF=7h02f04.x Unknown -0.4-0.6 gb:bf59387 /DB_XREF=gi:6864 /DB_XREF=nac05a0 Unknown -0.5-0.6 gb:ai378647 /DB_XREF=gi:488500 /DB_XREF=tc57a04.x Unknown -0.6-0.6 gb:aa577678 /DB_XREF=gi:2355862 /DB_XREF=nn22f08.s MTND6-0.9-0.6 gb:nm_7374. /DB_XREF=gi:2775487 /GEN=MTND6 /TID Unknown -0.3-0.6 gb:ak000680. /DB_XREF=gi:7020924 /FEA=FLmRNA /CNT PAPPA -0.3-0.5 X X X gb:aa48534 /DB_XREF=gi:72559 /DB_XREF=zl06d06.s COP9-0.2-0.5 gb:bc003090. /DB_XREF=gi:3846 /FEA=FLmRNA /CN LSM5-0.3-0.5 gb:au53477 /DB_XREF=gi:04998 /DB_XREF=AU5347 Unknown -0.3-0.5 gb:al05064. /DB_XREF=gi:4884378 /GEN=DKFZp586C6

THBD -0.7-0.5 gb:nm_00036. /DB_XREF=gi:4507482 /GEN=THBD /FEA= IGFBP -0.4-0.5 gb:nm_000596. /DB_XREF=gi:450464 /GEN=IGFBP /FEA IDH -0.3-0.5 gb:d3889. /DB_XREF=gi:4648 /GEN=Id-H /FEA=FLmR ZEB () -0.2-0.5 X X X X gb:u270. /DB_XREF=gi:52972 /FEA=FLmRNA /CNT=2 / Unknown -0.3-0.5 gb:ab02068. /DB_XREF=gi:4240236 /GEN=KIAA0874 /FE DNAJC8-0.3-0.5 X gb:aa843895 /DB_XREF=gi:2930346 /DB_XREF=ak09g0.s ATM -0.5-0.5 X gb:u82828 /DB_XREF=gi:2304970 /FEA=mRNA /CNT=3 /T Unknown -0.4-0.5 gb:ak000002. /DB_XREF=gi:7209304 /GEN=FLJ00002 /FE RPS2-0.4-0.5 gb:aw024383 /DB_XREF=gi:587793 /DB_XREF=wv03e06.x MTAP44-0.4-0.5 gb:nm_00647. /DB_XREF=gi:5453743 /GEN=MTAP44 /FE Unknown -0.5-0.5 gb:ai535683 /DB_XREF=gi:444988 /DB_XREF=cong.P. LOC55828-0.3-0.5 gb:nm_08443. /DB_XREF=gi:8923850 /GEN=LOC55828 /F Unknown -0.3-0.5 gb:al33049. /DB_XREF=gi:6453464 /GEN=DKFZp434E3 Unknown -0.4-0.5 gb:nm_04650. /DB_XREF=gi:766233 /GEN=KIAA0798 /F Unknown -0.4-0.5 gb:ai74220 /DB_XREF=gi:50498 /DB_XREF=wg39c02.x Unknown -0.3-0.5 gb:aa77568 /DB_XREF=gi:283505 /DB_XREF=zf3a02.s ADAMTS -0.6-0.5 gb:ak023795. /DB_XREF=gi:0435838 /FEA=mRNA /CNT= MAIL -0.5-0.5 gb:be646573 /DB_XREF=gi:9970884 /DB_XREF=7e89c0.x TRIM6-0.4-0.5 gb:af220030. /DB_XREF=gi:2407390 /GEN=TRIM6 /FEA= CS- -0.5-0.5 gb:af00540 /DB_XREF=gi:252972 /DB_XREF=AF00540 Unknown -0.3-0.5 gb:aw52589 /DB_XREF=gi:6200489 /DB_XREF=xf76g02.x Unknown -0.4-0.5 gb:bg484552 /DB_XREF=gi:34683 /DB_XREF=6025057 Unknown -0.3-0.5 gb:aa779684 /DB_XREF=gi:283905 /DB_XREF=af43e03.s CALM2-0.5-0.5 gb:al04607 /DB_XREF=gi:5434 /DB_XREF=DKFZp434 PTMA -0.6-0.5 gb:ai0886 /DB_XREF=gi:6359749 /DB_XREF=HA0306 /FE Unknown -0.3-0.5 gb:aw34977 /DB_XREF=gi:638523 /DB_XREF=UI-H-BI-a Unknown -0.4-0.5 gb:ai692523 /DB_XREF=gi:4969863 /DB_XREF=wd73d06.x Unknown -0.4-0.5 gb:ai374739 /DB_XREF=gi:474729 /DB_XREF=tc32d2.x Unknown -0.5-0.5 gb:ai76003 /DB_XREF=gi:575680 /DB_XREF=wh83a07.x Unknown -0.4-0.5 gb:ai937080 /DB_XREF=gi:5675950 /DB_XREF=wp72g2.x Unknown -0.3-0.5 gb:bg93589 /DB_XREF=gi:4294065 /DB_XREF=60287 Unknown -0.3-0.5 gb:al534095 /DB_XREF=gi:2797588 /DB_XREF=AL534095 SFRS3-0.4-0.5 gb:be927772 /DB_XREF=gi:0453848 /DB_XREF=MR3-CT0 H05E3-0.3-0.5 gb:u8267 /DB_XREF=gi:728033 /FEA=DNA_9 /CNT=6 /TID Unknown -0.5-0.5 gb:n7074 /DB_XREF=gi:227654 /DB_XREF=za86d.s /C THBD -0.5-0.4 gb:nm_00036. /DB_XREF=gi:4507482 /GEN=THBD /FEA= TM7SF -0.7-0.4 gb:nm_003272. /DB_XREF=gi:4507544 /GEN=TM7SF /FE APAF -0.5-0.4 X X gb:nm_03229. /DB_XREF=gi:708332 /GEN=APAF /FEA HAS2-0.5-0.4 gb:nm_005328. /DB_XREF=gi:4885390 /GEN=HAS2 /FEA= H4FE -0.7-0.4 gb:nm_02968. /DB_XREF=gi:45029 /GEN=H4FE /FEA Unknown -0.6-0.4 gb:ab020684. /DB_XREF=gi:4240242 /GEN=KIAA0877 /FE MKPX -0.5-0.4 gb:nm_02085. /DB_XREF=gi:99043 /GEN=MKPX /FEA= Unknown -0.5-0.4 Cluster Incl. AA5065:zl06h03.r Homo sapiens cdna, 5 en

PRO073-0.5-0.4 gb:ai446756 /DB_XREF=gi:4297435 /DB_XREF=tj5d04.x / TASR -0.5-0.4 gb:ai954700 /DB_XREF=gi:574700 /DB_XREF=wq32b06.x PRO073-0.7-0.4 gb:ai475544 /DB_XREF=gi:4328589 /DB_XREF=tc92a05.y Unknown -0.6-0.4 gb:n76327 /DB_XREF=gi:238905 /DB_XREF=yv39c02.r /C Unknown -0.5-0.4 gb:n32832 /DB_XREF=gi:5323 /DB_XREF=yw85g06.s / NNMT -0.5-0.4 gb:nm_00669. /DB_XREF=gi:5453789 /GEN=NNMT /FEA= Unknown -0.6-0.4 gb:ab02398. /DB_XREF=gi:4589605 /GEN=KIAA098 /FE PTTG3-0.5-0.4 gb:nm_02000. /DB_XREF=gi:0337606 /GEN=PTTG3 /FE GJA -0.5-0.3 gb:nm_00065.2 /DB_XREF=gi:475536 /GEN=GJA /FEA= Unknown -0.5-0.3 gb:nm_04705. /DB_XREF=gi:7662263 /GEN=KIAA076 /F Unknown -0.5-0.3 gb:au5338 /DB_XREF=gi:04659 /DB_XREF=AU533 Unknown -0.5-0.3 gb:ak023825. /DB_XREF=gi:0435876 /FEA=mRNA /CNT= Unknown -0.5-0.3 gb:nm_07945. /DB_XREF=gi:8923656 /GEN=FLJ20730 /F Unknown -0.5-0.2 gb:ai97246 /DB_XREF=gi:5769332 /DB_XREF=wr39d0.x KBRAS -0.5-0.2 gb:ai97020 /DB_XREF=gi:5766946 /DB_XREF=wq89d09.x () The online versions of both TargetScan and TargetRank are based on an incomplete 3'UTR sequence for ZEB of 542 bp. The complete ZEB 3'UTR contains 954 bp (gb:u270) and is predicted to be a target of both mir-200a and mir-200c by TargetScan and TargetRank.

Table S2: The top 20 genes most downregulated in MDA-MB-23 cells transfected with only mir-200a mir-200a mir-200c TargetScan TargetRank GenBank Gene Fold down Fold down mir-4/200a mir-200b,c/429 mir-200a mir-200c Accession # Unknown 2.3 NC NM_032923. DLG2 0.56 NC NM_00364. Unknown 9.85 NC BC03339. SDR-O 8.57 NC NM_48897. Unknown 7.46 NC AF339829. MKP 6.06 NC AB033338. Unknown 6.06 NC AL832555. KCNJ3 3.25 NC X AB03889. PRO024 2.4 NC NM_0420. Unknown 2.00 NC AA66276 Unknown 2.00 NC AL833020. NAPL3.87 NC X NM_004538. H4F2.87 NC NM_003548. TIMELESS.74 NC AK00072. Unknown.74 NC AA876372 Unknown.74 NC AI42320 Unknown.74 NC BC043608. Unknown.74 NC AK096609. IL.62 NC NM_00064. Unknown.62 NC AI38223

Table S3: The top 20 genes most downregulated in MDA-MB-23 cells transfected with only mir-200c mir-200a mir-200c TargetScan TargetRank GenBank Gene Fold down Fold down mir-4/200a mir-200b,c/429 mir-200a mir-200c Accession # Unknown NC 3.93 AI26576 Unknown NC 3.00 AW452357 H3FA NC 2.3 NM_003529. Unknown NC 2.3 AF086073. ADRB NC 9.85 X AI625747 Unknown NC 9.9 BF222940 Unknown NC 8.57 AI655633 Unknown NC 7.46 BF47693 Unknown NC 7.46 AI23346 RASGRP2 NC 6.50 AI68882 CQR NC 6.06 W72082 Unknown NC 4.92 AL83258. Unknown NC 4.92 AA56795 Unknown NC 4.59 NM_04729. TCRA NC 4.29 M5565. Unknown NC 4.29 BC020583. COMP NC 3.03 NM_000095. Unknown NC 2.64 AI96235 Unknown NC 2.30 NM_04934. Unknown NC 2.30 BC00275.

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