18 IN VIVO ΣΟΖΠΗΚΝΞΝΗΝΚΔΛΝΗ ΞΑΟΑΚΔΡΟΝΗ 1. WAVELENGTH (infrared sprectrum > 700nm) NdYAG : 1064, 1320, 1540 nm Diode : 870, 930 nm 2. PULSE TIME: pulsed lasers TRT of nail unit = 1ms long pulse: ms (10-3) short pulse: μs(10-6), nanosec(10-9), femto (10-15)
19 IN VIVO ΣΟΖΠΗΚΝΞΝΗΝΚΔΛΝΗ ΞΑΟΑΚΔΡΟΝΗ 3. FREQUENCY (Hz = pulses /sec) 4. SPOT SIZE penetration increases using a larger spot size 1 10 mm 5. FLUENCE fluence = J/cm2 : J/cm2
20 FDA APPROVED LASERS
21 FDA APPROVED LASERS
23 Kojaref et al Novel laser therapy in treatment of onychomycosis J Laser Health Academy patients Trichophytum, Candida, Aspergillus NdYAG laser (Fotona) long pulse Priming with urea 40% three days pre-op Fluence of J/cm2 with pulse time of 35ms Three passes of 2 min each Temperature between Ν C 4 sessions with an interval of 7 days No relapse after 12-month follow up 100% Mycological Cure
25 The Effect of Q-Switched Nd:YAG 1064nm/532nm Laser in the Treatment of Onychomycosis In Vivo. Kalokasidis K1, Onder M2, Trakatelli MG3, Richert B4, Fritz K5. Dermatology Research and Practice; 2013 In this prospective clinical study, the Q-Switched Nd:YAG 1064nm/532nm laser (Light Age, Inc., Somerset, NJ, USA) was used on 131 onychomycosis subjects (94 females, 37 males; ages 18 to 68 years). Mycotic cultures were taken and fungus types were detected. The laser protocol included two sessions with a one-month interval. Treatment duration was approximately 15 minutes per session and patients were observed over a 3-month time period. Laser fluencies of 14J/cm(2) were applied at 9 billionths of a second pulse duration and at 5Hz frequency. Follow-up was performed at 3 months with mycological cultures. Before and after digital photographs were taken. Adverse effects were recorded and all participants completed "self-evaluation questionnaires" rating their level of satisfaction. All subjects were well satisfied with the treatments, there were no noticeable side effects, and no significant differences were found treating men versus women. At the 3-month follow-up 95.42% of the patients were laboratory mycologically cured of fungal infection. This clinical study demonstrates that fungal nail infections can be effectively and safely treated with Q-Switched Nd:YAG 1064nm/532nm laser. It can also be combined with systemic oral antifungals providing more limited treatment time.
26 Treatment of onychomycosis with a 1,064-nm long-pulsed Nd:YAG laser. Moon SH, Hur H, Oh YJ, Choi KH, Kim JE, Ko JY, Ro YS. J Cosmet Laser Ther Aug;16(4): doi: / Epub 2014 Apr 29. PMID: [PubMed - in process]
27 Treatment of onychomycosis with a 1,064-nm long-pulsed Nd:YAG laser. Moon SH1, Hur H, Oh YJ, Choi KH, Kim JE, Ko JY, Ro YS. Abstract Abstract Background: There are various treatment modalities of onychomycosis. Of these, however, oral antifungal therapies are complicated by potential drug interactions and systemic effects, and the surgical treatment can result in prolonged pain. Therefore, a new, safe and effective therapy is needed that can improve the aesthetic appearance of the nails. Objective: The purpose of this study was to evaluate the effect of treatment of onychomycosis with a 1,064-nm long-pulsed Nd:YAG laser. Methods: 13 patients (31 toenails, 12 fingernails) received five treatment sessions at 4-week intervals with a 1,064-nm long-pulsed Nd:YAG laser. Parameters for each treatment were 6 mm spot size, 5 J/cm(2) fluence, 0.3 ms pulse duration and 5 Hz pulse rate. Results: Of the 13 patients, 8 (61.5%) were women and 5 were men. The mean age of the patients was 62. Of the 43 nails, 4 (9.3%) achieved a complete cure (9.3%), 8 had excellent treatment outcomes (18.6%) and 31 had good treatment outcomes (72%). None of the 13 patients experienced any discomfort except for a mild burning sensation and there were no adverse effects. Conclusions: Our results demonstrate that the 1,064-nm long-pulsed Nd:YAG laser could be a safe and effective treatment modality in the management of patients with onychomycosis.
28 Toenail onychomycosis treated with a fractional carbon-dioxide laser and topical antifungal cream. Lim EH, Kim HR, Park YO, Lee Y, Seo YJ, Kim CD, Lee JH, Im M. J Am Acad Dermatol May;70(5): doi: /j.jaad Epub 2014 Mar 18.
29 Traditional pharmacotherapy for onychomycosis has low to moderate efficacy and may be associated with adverse reactions and medication interactions limiting its use in many patients. OBJECTIVE: We evaluated the clinical efficacy and safety of a fractional carbon-dioxide laser with topical antifungal therapy in the treatment of onychomycosis. METHODS: In all, 24 patients were treated with fractional carbon-dioxide laser therapy and a topical antifungal cream. Thelaser treatment consisted of 3 sessions at 4-week intervals. Efficacy was assessed based on the response rate from standardized photographs, a microscopic examination of subungual debris, and subjective evaluations. RESULTS: Among the patients, 92% showed a clinical response and 50% showed a complete response with a negative microscopic result. The factors that influenced a successful outcome were the type of onychomycosis and the thickness of the nail plate before treatment. The treatment regimen was well tolerated and there was no recurrence 3 months after the last treatment episode. LIMITATIONS: The study followed up only 24 patients and there were no relevant treatment controls. CONCLUSIONS: Fractional carbon-dioxide laser therapy, combined with a topical antifungal agent, was effective in the treatment of onychomycosis. It should be considered an alternative therapeutic option in patients for whom systemic antifungal agents are contraindicated.
30 The use of the Er:YAG 2940nm laser associated with amorolfine lacquer in the treatment of onychomycosis. Morais OO1, Costa IM, Gomes CM, Shinzato DH, Ayres GM, Cardoso RM. An Bras Dermatol Sep-Oct;88(5): doi: /abd
31 Abstract Onychomycosis is a common disease, accounting for up to 50% of all ungual pathologies. We have been developing a clinical trial (ClinicalTrials.gov: NCT ) using a 2940nm Er:YAG laser to fractionally ablate human nails in vivo, aiming to increase topical amorolfine lacquer delivery to the nail unit, increasing the efficacy of topical treatment of distal and lateral subungual onychomycosis. Partial results have shown an increase in areas of nail plate free of disease. We believe that ablative lasers can increase the efficacy of topical onychomycosis treatment.
32 ΠΚΞΔΟΑΠΚΑΡΑ In Vitro μελέηερ σωπίρ ανηίζηοιση in Vivo εθαπμογή In Vivo μελέηερ μη ηςσαιοποιημένερ, βπασςσπόνιερ και μη ζςγκπιηικέρ Ανάγκη για πιο έγκςπερ μελέηερ με μακποσπόνιο Follow-up και <<ζηανηάπιζμα>> παπαμέηπων
Issue 4 Vol. 3 December 2012 www.forumclinicaloncology.org (PRINTED VERSION) FORUM of CLINICAL ONCOLOGY Quarterly official publication of the Hellenic Society of Medical Oncology ISSN: 1792-345X Thoughts
ANALYSIS OF SCIENTIFIC STUDIES (UNTIL NOV 2010) A) FULL ARTICLES PUBLISHED IN ENGLISH IN JOURNAL CITATION REPORTS (PUBMED, SCOPUS) 1) ACUTE EFFECTS OF NICOTINE WITHDRAWAL SYNDROME IN PILOTS DURING FLIGHT
INFRARED POLARIZED LIGHT FACILITATES AND IMPROVES THE QUALITY OF SKIN WOUND HEALING IN THE RAT MODEL. (EXPERIMENTAL STUDY) Iordanou P 1, Bellou P 2., Christopoulou I 1., Prelorendjos A 3., Babatsikou F
Issue 2 Vol. 4 June 2013 www.forumclinicaloncology.org (PRINTED VERSION) FORUM of CLINICAL ONCOLOGY Quarterly official publication of the Hellenic Society of Medical Oncology ISSN: 1792-345X Cancer and
Πέντε κρίσιµες ερωτήσεις για την µετάγγιση πλάσµατος Μ. Πολίτου Επίκουρη Καθηγήτρια Ιατρικής Σχολής ΕΚΠΑ Δ/ντρια Ν.Υ. Αιµοδοσίας ΑΡΕΤΑΙΕΙΟ Πρέπει να χρησιµοποιείται το πλάσµα για την αναστροφή της δράσης
ehealth Consumer Trends Survey in Greece: Results of the 1 st phase FORTH-ICS TR-365, December 2005 (Updated July 2006) C. E. Chronaki MSc 1, A. Kouroubali PhD 1, L. Esterle MD, PhD 1,3, E. Orphanoudaki
Issue 4 Vol. 4 December 2013 www.forumclinicaloncology.org (PRINTED VERSION) FORUM of CLINICAL ONCOLOGY Quarterly official publication of the Hellenic Society of Medical Oncology ISSN: 1792-345X How much
BOOK OF ABSTRACTS 14 TH INTERNATIONAL CONFERENCE OF THE A.P.P.A.C. UNDER THE AUSPICES OF The Hellenic National Commission for UNESCO The Municipality of Athens The Hellenic Ministry of Health and Social
IT Skills: The Business Gain Measuring Employees Efficiency after e-skills Training & Certification IT Skills: The Business Gain 1 2 ALBA Graduate Business School 2010 Contents Executive summary 4 1. Introduction
Issue 3 Vol. 4 September 2013 www.forumclinicaloncology.org (PRINTED VERSION) FORUM of CLINICAL ONCOLOGY Quarterly official publication of the Hellenic Society of Medical Oncology ISSN: 1792-345X Practicing
Βιοχημική υποτροπή σε ασθενή με καρκίνο του προστάτη: Θα νικήσουμε τον καρκίνο, θα χάσουμε τον ασθενή! Διονύσης Μητρόπουλος Καθηγητής Ουρολογίας Ιατρική Σχολή Πανεπιστημίου Επιθετικοί θεραπευτικοί χειρισμοί
Αρθροσκοπική αποκατάσταση των ρήξεων του τενοντίου πετάλου 1 του ώµου: µεσοπρόθεσµα αποτελέσµατα 2 ΠΕΡΙΛΗΨΗ Παρουσιάζουµε τα αποτελέσµατα της αρθροσκοπικής αποκατάστασης ρήξεων τενοντίου πετάλου του ώµου,
Network of Cohorts in Europe and the United States HEALTHY AGEING: DEFINITION, RISK FACTORS AND IMPLICATIONS FOR PUBLIC HEALTH Friday, 23 rd January 2015 MEGARON - The Athens Concert Hall Athens, GREECE
Pancyprian Orthopaedic Conference Foot Final Program Accredited with 12 CME points. & Under the Auspices of The Minister of Health Ankle In Association: with the Hellenic Association of Orthopaedic Surgery
Dental extractions and bisphosphonates: the assessment, consent and management, a proposed algorithm N. Malden, 1 C. Beltes 2 and V. Lopes 3 VERIFIABLE CPD PAPER IN BRIEF A method of placing patients into
Β. Μ. Κάρτσου, A. Seamanduras, S. Koo και Α. Ι. Ζάβρας: Επιπτώσεις της χρήσης διφωσφονικών στην οδοντιατρική 1 Επιπτώσεις της χρήσης διφωσφονικών στην οδοντιατρική Implications of bisphosphonate use in
NEWSLETTER Έκδοση Απριλίου Μαΐου 2010 ΤΕΥΧΟΣ 42 Αγαπητές-οι φίλες-οι, Στις σελίδες του 42 ου ηλεκτρονικού µας περιοδικού µπορείτε να περιηγηθείτε και να διαβάσετε τα ακόλουθα: ΠΕΕΡΙΙΕΕΧΟΜΕΕΝΑ ΑΑππόό ττοονν
24th International Meeting Cardiology Today 5-6 April 2014 Hilton Park Hotel Nicosia, Cyprus Final Program & Abstracts Book Organized by: Cyprus Society of Cardiology www.cycardio.com CME points will be