Current Knowledge on Molecular Features of Seafood Allergens
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1 August Current Knowledge on Molecular Features of Seafood Allergens Kazuo S=>DB> Department of Food Science and Technology, Tokyo University of Marine Science and Technology: Konan, Minato-ku, Tokyo , Japan Key words: allergen; epitope; seafood; collagen; food allergy; tropomyosin; parvalbumin PDF foodallergy.jp/ 05_syoku/index.html I IV I I Fig. 1 I MHC II T T T T Th1 Th2 I Th2 Th2 4 T B B IgA, IgD, IgE, IgG IgM
2 140 Vol. 51, No. 4 IgE Fig. 1. Crisis mechanism of food allergy 5 4 B IgE IgE 2 IgE 2.2 T T T IgE IgE IgE IgE B 4 IgE B IgE IgE B T IgE T IgE IgE IgE T IgE I 1), 2) 3) 3.1 Gadus callarias IgE Ishizaka 4) 1966 Aas Elsayed G. callarias M 5), 6) M Gad c 1 Gad c ) 8) 9) 10) 11) 9) 12) 14)
3 August Ca 2 12 kda 15) 16) 17) 18) 5 19) 20) 21), 22) Fig. 2 Fig a 108 b 23) b b 6 (Ala-13, Leu-15, Cys-18, Phe-66, Gln-68, Thr-78) 24) Fig. 2 Gad c a b 6 Fig. 3. Stereo structure of Pacific mackerel parvalbumin Fig. 2. Amino acid sequences of fish parvalbumins Accession numbers for parvalbumins (UniprotKB/Swiss-Prot database for cod parvalbumin and DDBJ/EMBL/ GenBank databases for the other parvalbumins): Japanese eel Anguilla japonica, AB375263; sardine Sardinops melanostictus, AB375262; carp Cyprinus carpio 1, AJ292211; carp 2, AJ292212; Atlantic salmon Salmo salar 1, X97824; Atlantic salmon 2, X97825; cod Gadus callarias, P02622; horse mackerel Trachurus japonicus, AB211364; crimson sea bream Evynnis japonica, AB375264; Pacific mackerel Scomber japonicus, AB091470; skipjack Katsuwonus pelamis, AB375265; flounder Paralichthys olivaceus, AB The residues identical with those of Japanese eel parvalbumin are shown as dashes ( ). Conformational IgE epitope regions assumed for carp parvalbumin (isoform 2) and linear IgE epitope regions proposed for cod and Pacific mackerel parvalbumins are boxed. EF-hand motifs and Ca 2 -binding sites are shown by underlines and asterisks, respectively, below the sequence of flounder parvalbumin.
4 142 4 Gad c 1 Gad c 1 a b a- a- EF-hand AB, CD, EF 3 EF-hand CD EF Ca 2 Fig ) IgE 26), 27) Gad c 1 ph IgE Ca 2 IgE 25 28) IgE 4 (33 44, 49 64, 65 74, 88 96) IgE 29) (Fig. 2) IgE Gad c 1 IgE 30) IgE Gad c 1 4 IgE IgE (Fig. 2) Ala IgE IgE Lys-27, Lys-28, Cys-33 Lys-38 Ser-23, His-26 Lys-31 7 IgE IgE IgE IgE 7) 31) (EGTA) Ca 2 IgE Ca 2 Vol. 51, No. 4 IgE IgE Gad c 1 IgE Ca 2 3 (23 37, 77 79, 87 94; Fig. 2) IgE 32) IgE IgE IgE Ca 2 Ca 2 IgE Ca 2 CD Asp-51 Asp-53, EF Asp- 90 Asp-92 Ala IgE 33) 31) CD Asp-51 EF Asp-90 Ala (D51/90A) IgE (Fig. 4) BALB/c D51/ 90A IgE D51/90A IgE 2 T ) 34) Sakaguchi ) 36) 1/3 37) kda a ) Gly-X-Y
5 August Fig. 4. Analysis of IgE reactivity of three Pacific mackerel parvalbumin (Sco j 1) mutants (D51A, D90A and D51/90A) by fluorescence ELISA D51A, replacement of Asp-51 by Ala; D90A, replacement of Asp-90 by Ala; D51/90A, replacement of both Asp-51 and Asp-90 by Ala. Data are shown as IgE reactivity, taking the IgE reactivity of Sco j 1 as 100. a 2 a 1 (a1) 2 a2 (a1) 2 a2 a 3 a1a2a3 a1a2a3 39) (a1) 2 a2 a1a2a3 40) a IgE 34) 34), 36) 41), 42) 34) 36) 2 a a2 IgE 43) a2 IgE IgE (IPGEF- GKPGP) 44) IgE a a 34), 37) a2 IgE Fig. 5. Amino acid sequence alignment of the region of collagen a2 chains from fish and mammals DDBJ / EMBL / GenBank accession numbers: rainbow trout Oncorhynchus mykiss, AB052837; chum salmon Oncorhynchus keta, AB075699; bastard halibut Paralichthys olivaceus, AB ; zebrafish Danio rerio, BC071278; human, BC042586; bovine, AB008683; rabbit, D49399; mouse, AK ) a2 Fig IgE a2 IgE a1 a3 a IgE IgE
6 144 Vol. 51, No (41 kda) 46) (94 kda) 47) 25 kda 48) 61 kda 49) Fig. 6. Schematic structure of thin myofibril ) 51) 53) 54) 54) 53), 55) 56) 57), 58) 58) pan-allergen 59) (Fig. 6) 60) 35 kda 2 2 a- coiled-coil 7 (abcdefg) a d e g coiled-coil (Fig. 7) 3 (b, c, f) Fig. 8 fast slow-twitch slow-tonic 3 53) fast slow slow-tonic 2 C ( ) 90 Fig. 7. Schematic view of the coiled-coil structure showing the position of residues in the heptad repeat (abcdefg) of tropomyosin fast slow king crab fast fast slow mantis shrimp fast fast 95 Antarctic krill Pacific krill fast slow (Fig. 9) acorn barnacle (Fig. 9) 53), 59), 61), 62)
7 August Fig. 8. Amino acid sequences of tropomyosins from crustaceans and terrestrial arthropods In the case of decapod crustaceans, the tropomyosin type (fast, slow-twitch or slow-tonic) is indicated in parenthesis after the name. DDBJ/EMBL/GenBank accession numbers: acorn barnacle Balanus rostratus, AB ; Antarctic krill Euphausia superba, AB308319; Pacific krill Euphausia pacifica, AB289604; brown shrimp Penaeus aztecus, DQ151457; black tiger shrimp Penaeus monodon, AB270629; pink shrimp Pandalus eous, AB ; American lobster Homarus americanus fast tropomyosin, AF034954; American lobster slow-twitch tropomyosin, AF034953; American lobster slow-tonic tropomyosin, AY521627; king crab Paralithodes camtschaticus fast tropomyosin, AB270632; king crab slow-tonic tropomyosin, AB270633; snow crab Chionoecetes opilio, AB270634; horsehair crab Erimacrus isenbekii slow-twitch tropomyosin, AB270635; horsehair crab slow-tonic tropomyosin, AB270636; mantis shrimp Oratosquilla oratoria, AB308320; American cockroach Periplaneta americana, AF106961; European house dust mite Dermatophagoides pteronyssinus, AF The residues identical with those of brown shrimp tropomyosin are shown as dashes ( ). The IgE-binding epitopes proposed for brown shrimp tropomyosin are boxed.
8 146 Vol. 51, No. 4 Fig. 9. Molecular phylogenetic tree for crustacean tropomyosins The tree was constructed by the Neighbor Joining method. Bootstrap values 70 are reported on nodes of the tree. The length of branches indicates the genetic distance between the tropomyosins. DDBJ/EMBL/GenBank accession numbers are shown in parentheses after scientific names. IgE IgE (Pen a 1) 8 (43 55, , , , , , , ) IgE 63), 64) (Fig. 8) IgE IgE 12 (Leu-46, Leu-53, Leu-95, Ser-136, Glu-145, Val-191, Val-199, Arg-255, Leu-260, Ser-269, Thr-277, Phe-278) Pen a 1 65) Pen a 1 IgE 8 5 IgE (88 101, , , , ) 3 IgE fast slow slow-tonic 59), 63), 66) 59), 61) 80 5 IgE (88 101, , , , ) (Fig. 8) ) Yu 68) 40 kda 69) ATP
9 August Ca 2 (SCP) 20 kda Ca 2 (sarcoplasmic calcium-binding protein; SCP) 70) Ayuso 71) SCP SCP Ca 2 Ca 2 SCP IgE Ca 2 SCP, IgE ELISA 70) Fig SCP 8 10 IgE SCP SCP SCP 70) SCP fast SCP SCP Fig Ayuso 72) 20 kda (pi 4.2) 2 IgE 220 kda 2 20 kda 4 Fig. 10. Analysis of IgE reactivity of SCP (A), tropomyosin (B) and arginine kinase (C) purified from black tiger shrimp by fluorescence ELISA using sera from 16 patients Control data obtained with 14 healthy subjects were averaged and denoted by C. Values above the control mean 2SD (indicated by a dotted line in each panel) were judged to be positive ) 75) 76) 78) 76), 78) 81) IgE 59), 61) Fig
10 148 Vol. 51, No. 4 Fig. 11. Amino acid sequences of molluscan tropomyosins DDBJ/EMBL/GenBank accession numbers: Japanese flying squid Todarodes pacificus, AB218915; common octopus Octopus vulgaris, AB218917; disk abalone Haliotis discus discus, AB444939; whelk Neptunea polycostata, AB444941; bloody cockle Scapharca broughtonii, AB444942; Mediterranean mussel Mytilus galloprovincialis, AB ; Yesso scallop Patinopecten yessoensis, AB004636; Japanese oyster Crassostrea gigas, AB444943; short-neck clam Ruditapes philippinarum, AB444948; brown shrimp Penaeus aztecus, DQ The residues identical with those of brown shrimp tropomyosin are shown as dashes ( ). The IgE-binding epitopes proposed for brown shrimp tropomyosin are boxed. 70 (Table 1) (cephalopods) (Vetigastropoda) (Neogastropoda) (Arcoida) (Mytiloida) (Pectinidae) (Ostreidae) (Veneroida) 8 Pen a 1 8 IgE (Fig. 11) , , Pen a 1 8 IgE kda
11 August Table 1. Amino acid sequence identities ( ) among molluscan tropomyosins Cephalopods Gastropods Order: Vetigastropoda Order: Neogastropoda Order: Arcoida Order: Mytiloida Bivalves Order: Ostreoida Family: Pectinidae Family: Ostreidae Order: Veneroida Cephalopods Gastropods Order: Vetigastropoda Order: Neogastropoda Bivalves Order: Arcoida Order: Mytiloida Order: Ostreoida Family: Pectinidae Family: Ostreidae Order: Veneroida Cephalopods: golden cuttlefish Sepia esculenta (AB218913), fin reef squid Sepioteuthis lessoniana (AB218914), Japanese flying squid Todarodes pacificus (AB218915), neon flying squid Ommastrephes bartrami (AB218916) and common octopus Octopus vulgaris (AB218917). Gastropods: tropical abalone Haliotis asinina (AY320360), Japanese abalone Haliotis diversicolor (AF ), California red abalone Haliotis rufescens (X75218), disk abalone Haliotis discus discus (AB444939) and turban shell Turbo cornutus (AB444940) of the order Vetigastropoda; whelk Neptunea polycostata (AB444941) of the order Neogastropoda. Bivalves: bloody cockle Scapharca broughtonii (AB444942) of the order Arcoida; blue mussel Mytilus edulis (U40035), Mediterranean mussel Mytilus galloprovincialis (AB000907) and green mussel Perna viridis (AF216519) of the order Mytilida; akazara scallop Chlamys nipponensis (AB021681), noble scallop Chlamys nobilis (AF216520) and Yesso scallop Patinopecten yessoensis (AB004636) of the family Pectinidae; Japanese oyster Crassostrea gigas (AB444943) of the family Ostreidae; Japanese cockle Fulvia mutica (AB444944), surf clam Pseudocardium sachalinensis (AB444945), horse clam Tresus keenae (AB ), constricted tagelus Sinonovacula constricta (EU082209), razor clam Solen strictus (AB444947) and short-neck clam Ruditapes philippinarum (AB444948) of the order Veneroida. DDBJ/EMBL/GenBank accession numbers are indicated in parentheses , 3 5 Shimizu 82) b - b - b - IgE IgE SCP ) Audicana, M. T., Kennedy, M. W. Anisakis simplex: From obscure infectious worm to inducer of immune hypersensitivity. Clin. Microbiol. Rev., 21, (2008). 2) Daschner, A., Pascual, C. Y. Anisakis simplex: Sensitization and clinical allergy. Curr. Opin. Allergy Clin. Immunol., 5, (2005).
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