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1 Technology Review 1880 Sauerbrey f Kf 2 M/A, M g ng f M 1959 Sauerbrey f MHz OEM OEM 3 KELLER 1 21R 2 23/ bar1000bar 0.5%0.1% 0.2% , , 429,

2 A cm 2 K a 2% f M b 1 2 η Lu Lewis ξ 1 K πf Z c f πf c tan = tan 1991 S.J.Martin f0 Z q f f f c 1998 Lili Bao f f f 0 Z f Z q f 40 Makoto Muratsugu1993Fabien Josse Sauerbrey [456] AT fc 0 +C 1 ρ 1/2 1 +C 2 η 1/2 1 -C 3 ξ 1 -C 4 K f Au, Ag, Pt, Ni, Pd nm Ci1,2,3,4 i silane layer poly- ethyleneimine layer polyρ 1 2 Sensor World

3 Technology Review acrylanmide gel layera protein Alayer L DNA Muramatsu H [7] γ (SPQC) (ESPS) IgG Plomer M [8] f A 3 f 10MHz, /ml Carter RM [9] MHz AT 10 5 /ml 0139 DNA [10] Park IS 1 Sulfo-LC-SPDP CFU/ml (a). A IgG Kosslinger C [11] Andle [12] HIV, HIV [13] Suri CR 3-APTES PET A (b). AIgG 1ng/ml 3 IgG [14] Su X IgE 3

4 10MHz 9MHz AT DNA IgE 5300IU/ml [15] Chu X 9MHz (1) Langmuir K ass IgM, IgM mol/l -1, K i (2) DNA 593mg/ml mol/l -1 s -1 Lu HC 2 DNA (3)DNA DNA (4) (5) SpA, IgG DNA ssdna 0.3nmole/l 6MHz DNA DNA DNA A IgG Fawcett NC [22] 1~107µg/ml DNA ssdna Hz/dec. (µg/ml) ssdna 9MHz AT [18] -DNA DNA ploy(u) A-IgG dsdna, poly(a) IgG 500Hz Fawcett NC IgG IgG 5~127µg/ml , Hz/(µg/ml) [5] 8.5mg/ml DNA ssdna 9MHz IgG 5µl DNA AT ssdna 100nm Au ssdna 12.7mg/ml IgG 5µl 1ng IgG 0.95Hz Naomi FC [25] A DNA [20,21] 4 Sensor World

5 Technology Review [2]. Okahata Y [26] 9MHz DNA, :1-9 [3]. AT,2001,3: M13 DNA [4]. Nicolini c, Erokhin V, Facci P, et al. EcoRI Quartz balance DNA sensor. Biosensor Bioelectron, 1997, 12(7): [5]. Okahata Y [27,28] 10,2000,4: mer [6]. DNA, :51-52 [7]. Muramatsu H, Kimura K, Ataka T. Computation of equivalent circuit Niikura K parameters of quartz crystal in contact with liquid and study of liquid properties. Anal Chem, 1988, 60: [8]. Plomer M, Guilbault GC. PCR Development of a piezoelectric immuno PCR -sensor for the detection of enterobacteria. Enzyme Microb Technology, 1992, 14(3): Nicolini C [30] Keiko Ito [31] [1]. Sauerbrey G.The use of quartz Joseph Wang [32] oscillators for weighing thin layers and for microweighing. Z. Phys, 1959,155: L [9]. Carter RM, Mekalanos JJ. Quartz crystal microbalance detection of vibrio ssdna, : 220V/105V AC50/60Hz 250V 10A AC30V 5A DC :0.02g/cm 3 (Max) (ELISA) cm/ 25~500cm NPT3/2R3/2 RIA 30 C~+150 C 2.5kg FIA ( )

6 cholerate 0139 serotype. J Immounol Methods, 1995, 187(1): [10]. Park IS, Kim N. Thiolated Salmonella antibody immobilization onto the gold surface of piezoelectric quartz crystal. Biosens Bioelectron,1998,13(1): [11]. Kosslinger C, Drost S. A quartz crystal biosensor for measurement in liquids. Biosens Bioelectron,1992,7(6): Quartz balance DNA sensor. Biosenss 2001,21(1):9-14. Bioelectron,1997,12(7): [20]. DNA [31]. Keiko Ito, Koji Hashimoto, Yoshio Ishimori. Quantitative analysis for [21]. DNA solid-phase hybridization reaction and 20001:45-53 [22]. Fawcett NC, Evans JA, Chien LT, et al. Nucleic acid hybridization detection by piezoelectric resonance. Anal Lett, 1988, 21(7): binding reaction of DNA binder to hybrids using a quartz crystal microbalance. Anal Chem Acta,1996,327:29-35 [32]. Joseph Wang, Manuel Chicharro, Gustavo Rivas, et al. DNA Biosensor for [12]. [23]. Fawcett NC, Evans JA, Craven RD, et al. B. Proceeding of the ACS Division of the Detection of Hydrazines. Anal Chem, 1996, 68(13): ,19(2):83-87 Polymeric Materials Science and [13]. Suri CR, Jain PK. Development of Engineering,1997,76: Research Trend of Biomedicine piezoelectric crystal based micro [24]. Quartz-Crystal Sensor -gravinmetric immunoassay for 20008:63-65 Abstract: The biomedicine determination of insulin of insulin [25]. Naomi FC. DNA sensor by using a quartz-crystal sensor is the result concentration. J Biotechnol, 1995, 39(1): quartz crystal microbalance. Biochem of combining the molecular Biophys Res Commun, 1993,96(2): biology with microelectronics, [14]. Su X, Chew FT. Self-assembled [26]. Okahata Y, Matsunobu Y, Ljiro K,et al. monolayer-based piezoelectric crystal Hybridization of nucleic acids immobilized electrochemistry etc. The Research immunosensor for the quantification of total human immunoglobulin E. Anal Biochem, on a quartz crystal mirobalence. J Am Chem, 1992, 114: trend and structure principle of the biomedicine quartz-crystal sensor 1999, 273(1): [27]. Okahata Y, Kawase M.Kinetic, are introduced in this paper. [15]. Chu X, Lin ZH. Piezoelectric Measurements of DNA hybridization on an Keywords: Quartz-crystal, immunosensor for the detection of oligonucleotide-immobilized 27Mhz quartz Biomedicine, Immunity-sensor, immunoglobulin M. Analyst, 1995, 120 (12): [16]. Lu HC, Chen HM. A reusable and specific protein A-coated piezoelectric biosensor for flow injection immunoassay. Biotechnol Prog, 2000, 16(1): crystal microbalance. Anal Chem,1998,70: [28]. Caruso F, Rodda E. Quartz crystal microbalance study of DNA immobilization and hybridization for nucleic acid sensor development. Anal Chem, 1997,69:2043 DNA sensor [17] [29]. Niikura K, Matsuno H, Okahata Y ,8: Direct monitoring of DNA polymerase [18]. chain reactions on a quartz crystal fuzhi619@163.net IgG microbalance. J Am Chem Soc, 1998,120: 2000, 8: [19]. [30]..Nicolini C, Erokhin V, Facci P, et al. : Sensor World