chronic kidney disease CKD nuclear transcription factor kappa B NF-κB kinases IKK IκB kappab kinases IKK proteins NF-

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1 Vol. 38 Issue 24 December2013 NF-κB 1 2* chronic kidney disease CKD nuclear transcription factor kappa B NF-κB NF-κB CKD NF-κB chronic kidney disease CKD κ κb NF-κB P50 1 P52 P65 c-rel RelB N inflammatory cell macrophage MΦ T RHD DNA p65 p50 2 p65 C NF-κB renal interstitial fbrosis RIF 2 IκB IκB 3 nuclear transcription factor kappa B NF-κB Rel /NF-κB IκB IκBα IκBβ kinases IKK IκB kappab kinases IKK proteinsnf- -α tumor necrosis factor alpha IκBζ IκBε Bcl-3 p100 p105 NF-κB TNF-α transforming growth factor TGF-βl NF-κB NF-κB /IκB interleukin IL IκBα IκB IκB IκB kinases IKK IκB IκBα NF-κB NF-κB IKK NF-κB NF-κB IL- IKKα IKKβ IKKγ / NEMO NF-κB essential modulator IκBα IκBβ IκBα IκBβ 1α IL-1β IL-6 IL-8 TNF-α -1 MCP IKK IκBα IκBβ 1 NF-κB IL-1 TNF-α TGF 4-5 TAK1 NF-κB CKD IKK IL-1 NEMO TRAF6 1 NF-κB Lys NF-κB TAK1 TAB1 /2 TAK1 IKK 9 TNF-α RIP1 TAB2 /3 * jssunwei@ NEMO TAK1 IKK 10 TGF 163. com hubeilhliuhong@ 163. com 4246 RIP1 NEMO TRAF2 TRAF5 Akt /PKB IKK IKK IκB NF-κB

2 Vol. 38 Issue 24 December Fig. 1 NF-κB The intervention of Herbs on NF-κB signaling pathway MCP UUO NF-κB NF-κB TGF-βlMCP-1 TNF-α TGF-β3 TGF- TNF-α IL-1 β1 NF-κB TGF-β1 TGF-β1 ttg IL-1 TNF-α IL-1 TNF-α TGF-β1 extracelluar matrix NF-κB MCP-1 RIF ECM RIF MCP-1 13 MCP-1 NF-κB NF-κB p65 IκBα NF-κB MCP-1 IκBβ NF-κB MCP NF-κB TNF-α NF-κB /IκB NF-κB TNF-α TNF-α NF-κB MCP-1 NF-κB PPARγ NF-κB RIF 15 NF-κB TGF-β1 mrna NF-κB 19 IκB NF-κB p65 TGF-β1 MCP-1 TNF-α PPARγ NF-κB p65 TGF-β1 CKD 1 MCP-1 RIF NF-κB p65 MCP-1 ECM RIF 20 2 NF-κB TNF-α CKD NF-κB NF-κB 516 NF-κB NF-κB TNF-α 4247

3 Vol. 38 Issue 24 December2013 NF-κB NF-κB CKD NF-κB TGF-β1 TNF-α IL NF-κB 31 AGEs NF-κB TGF-β1 TNF-α ROS IκB NF-κB MCP-1 IL CKD NF-κB EGb 3 NF-κB 3. 1 NF-κB p65 IκBa NF-κB NF-κB 4 NF-κB NF-κB P TNF-α TNF-α -1PIAS1 N p65 /RelA NF-κB p65 DNA NF-κB 21 IκB NF-κB RIF NF-κB TNF-α NF-κB TNF-α NF-κB IκB UUO NF-κB NF-κB 34 IL-6 p65 23 TNF-α NF-κB T2DM HBZY-1 GMC 3. 3 TGF-β MCP-1 NF-κB TGF-β1 TGF-β 11 MCP-1 NF-κB DN 24 2 p65 NF-κB MCP-1 NF-κB NF-κB p65 MCP-1 MCP-1 NF-κB p65 DN NF-κB NF-κB adriamycin-induced nephropathy ADRN NF-κB MCP-1 IκBα NF-κB IκB 35 Giunt 36 NF-κB p65 NF-κB MCP-1 NF-κB IκB TGF-β TGF-β1 ADRN ADRN NF-κB IgAN TGF-β1 p65 IκBα 37 IgAN NF-κB IκB NF-κB DN 32 membranous nephropathy MN NF-κB p65 TNF-α NF-κB NF-κB TNF-α NF-κB p65 TGF-β1 MCP-1 IκBβ IκBα IκBβ NFκB /IκB 27 ADRN NF-κB p65 IκBα 38 NF-κB p65 IκBα DN NF-κB NF-κB MCP-1 39 NF-κB /IκB TGF-β1 NF-κB ADRN NF-κB ECM FRNS 40 NF-κB NF-κB MCP-1 NF-κB NF-κB /IκB NF-κB / TNF MCP GMC GMC TGF-β1 mrna NF-κB 4248

4 Vol. 38 Issue 24 December NF-κB MCP-1 NF-κB CKD 46 Thl /Th2 47 Thy1. 1 NF-κB NF-κB p65 IκB TGF-β1 MCP-1 48 TNF-α TGF-β1 MCP-1 TGF-β1 CKD IgA nephrin GBM nephrin slit dia-phragmsd nephrin nephrin SD SD nephrin Sagair Hussain 45 nephrin NF-κB nephrin NF-κB NF-κB NF-κB CKD 1 Table 1 NF-κB Intervention effect of herbs on NF-κB signaling pathway IgAN NF-κB NF-κB - 37 p65 TGF-β1 MCP-1 TGF-β1 NF-κB 23 HBZY-1 GMC IκB NF-κB - DN ECM 31 2 NF-κB p65 - DM 24 NF-κB TNF-α N- -β-d- 33 RIF 2 IL-6 TNF-α 34 NF-κB NF-κB p65 32 MN ColⅣ NF-κB 30 TGF-β1 mrna NF-κB GMC ECM 41 NF-κB MCP-1 - DN 42 NF-κB p65 IκBα - NF-κB/IκB NF-κB NF-κB/ - IKB TNF NF-κB MCP ROS 40 1Vidt D G A 20A. Inflammation in renal diseasej. Am J Cardiol 2 Papayianni A. Cytokinesgrowth factorsand other inflammatory mediators in glomerulonephritisj. Ren Fail Sanz A BSanchez-Nino M DRamos A Met al. NF-kappaB in 4249

5 Vol. 38 Issue 24 December2013 renal inflammation J. J Am Soc Nephrol Rangan GWang YHarris D. NF-kappaB signalling in chronic kidney disease J. Front Biosci κb J Morrissey JKlahr S. Transcription factor NF-kappaB regulation of renal fibrosis during ureteral obstructionj. Semin Nephrol Bauerle K TSchweppe R EHaugen B R. Inhibition of nuclear factor-kappa B differentially affects thyroid cancer cell growth apoptosisand invasion J. Mol Cancer Pacifico FMauro CBarone Cet al. Oncogenic and anti-apoptotic activity of NF-kappa B in human thyroid carcinomasj. J Biol Chem Hsu L CEnzler TSeita Jet al. IL-1beta-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKbeta J. Nat Immunol Habelhah H. Emerging complexity of protein ubiquitination in the NF-kappaB pathway J. Genes Cancer Wan YGu LSuzuki Ket al. Multi-glycoside of Tripterygium wilfordii Hook f. ameliorates proteinuria and acute mesangial injury induced by anti-thy1. 1 monoclonal antibodyj. Nephron Exp Nephrol e J NF-κBp65 MCP-1 ColⅢ J κb /IκB J J. 14Yamazaki SMuta TTakeshige K. A novel IkappaB protein IkappaB-zetainduced by proinflammatory stimulinegatively regulates nuclear factor-kappab in the nucleij. J Biol Chem Li X CZhuo J L. Nuclear factor-kappab as a hormonal intracellular signaling moleculefocus on angiotensin II-induced cardiovascular and renal injuryj. Curr Opin Nephrol Hypertens Aggarwal B BTakada YShishodia Set al. Nuclear transcription factor NF-kappa Brole in biology and medicine J. Indian J Exp Biol Renault M AJalvy SBelloc Iet al. AP-1 is involved in UTPinduced osteopontin expression in arterial smooth muscle cells J. Circ Res Nicholas S BKawano YWakino Set al. Expression and function of peroxisome proliferator-activated receptor-gamma in mesangial cells J. Hypertension Pt κb TNF-α 4250 J Zhang JWang SWang Ket al. Herpes simplex virus 1 DNA polymerase processivity factor UL42 inhibits TNF-alpha-induced NF-kappaB activation by interacting with p65 / RelA and p50 / NF-kappaB1 J. Med Microbiol Immunol κb J NF-κB J OPN /NFκB J IκB J NF-κB /IκB J NF-κB IκB J NF-kB NF-κB J J κb Ⅳ J NF-κB TNF-α J J Cheung G TSiow Y LO K. Homocysteine stimulates monocyte chemoattractant protein-1 expression in mesangial cells via NFkappaB activation J. Can J Physiol Pharmacol Giunti STesch G HPinach Set al. Monocyte chemoattractant 19. protein-1 has prosclerotic effects both in a mouse model of experimental diabetes and in vitro in human mesangial cellsj. PPARγ TGF-β1 J. Diabetologia IgA

6 Vol. 38 Issue 24 December2013 Th1 /Th2 -κb J Hussain SRomio LSaleem Met al. Nephrin deficiency acti- 38. NF-κB vates NF-kappaB and promotes glomerular injuryj. J Am Soc MCP-1 J Nephrol UUO 46. IgA NF-κB J. J J P smad2 TGF-β1 TGF-β1 mrna NF-κB J. CTGF D NF-κB MCP-1 J. nephrin podocin J D'Amico GBazzi C. Pathophysiology of proteinuria J. Kidney Int Huber T BKottgen MSchilling Bet al. Interaction with podocin facilitates nephrin signalingj. J Biol Chem IgA nephrin podocin J Regulatory mechanism of NF-κB signaling pathway on renal tissue inflammation in chronic kidney disease and interventional effect of traditional Chinese medicine LIU Hong 1 SUN Wei 2* WAN Yi-gang 3 TU Yue 1 YU Bing-yin 1 HU Hao 1 1. Nanjing University of Chinese Medicine Nanjing China 2. Department of NephrologyJiangsu Provincial Hospital of Chinese MedicineNanjing China 3. Department of Traditional Chinese MedicineNanjing Drum Tower HospitalAffiliated Hospital of Nanjing University Medical SchoolNanjing China AbstractIn chronic kidney disease CKD inflammatory responses during the progression of renal tissue and tissue injury related causes its progression to end-state renal disease. Among themnuclear factor nuclear factornf-κb signaling pathway by regulating the corresponding nuclear expression of target gene transcriptionas well as affecting the synthesis of inflammatory mediators induction of inflammation lead to kidney damage and renal fibrosis. Some single herbs and their extracts such as Astragali Radix Scutellariae RadixGinkgo Foliumand some traditional Chinese medicine such as Danggui Buxue decoctionqilian decoctioncan reduce the inflammatory damage induced by renal tissue NF-κB signaling pathway and delay the progression of CKD. Key wordschronic kidney diseasetraditional Chinese medicinenf-κbsignaling pathway doi /cjcmm