2017 10 39 5 477 * 010017 CEA CA199 CA125 CA153 RNA microrna Exosomes R737.9 A DOI:10.16343/j.cnki.issn.2095-512x.2017.05.022 2095-512X 2017 05-0477-05 THE PROGRESS OF BIOMARKERS IN BREAST CANCER CAO Yin-fang DING Hai-tao Inner Mongolia People`S Hospital Hohhot 010017 China Abstract Breast cancer which was associated with lots of risk factors including environmental factors and personal lifestyle plays an important role in female health.previous studies have demonstrated that the combined application of tumor markers such as CEA CA199 CA125 and CA153 are useful for the early diagnosis and prognosis however the disadvantage for both the sensitively and specificity of the application exists.the further development of new tumor markers can provide clues for early diagnosis and prognosis which is valuably.this study has a systematic review and focus on new tumor markers which can provide the further understanding of micrornas and Exosomes. Key words breast cancer early diagnosis tumor marker biology prognosis breast cancer BC 1 3% 2017-03-18 2017-08-28 201528 1977- E-mail nmgyy2302@ 163.com 010017
478 Journal Of Inner Mongolia Medical University Oct.2017 Vol.39 No.5 CA125 6 CA125 1 CA125 CEA 125 7 CA125 153 CA153 199 1.4-2 huaman epidermal CA199-2 HER-2 growth facter-2 HER-2 LPA FER HER-2 17q12 ~ 21 HER-2 1.1 carcinoembryonic antigen CEA CEA HER-2 2 CEA 9 1.5 lysophosphatidic acid LPA LPA CEA G CEA LPA CEA CEA 8 LPA LPA 10 3 1.6 FER 1.2 153 carbohydrate antigen153 CA153 CA153 FER CA153 CA153 H 4 30% ~ 50% CA153 80% L CA153 FER 11 CA153 1.7 TSGF 5 1.3 125 carbohydrate antigen125 CA125 8 HER-2 FER TSGF TSGF CA125 CA125 TSGF
2017 10 39 5 479 Bcl-2 p53 TSGF 18 mir- 12 2 RNA microrna 3 Exosomes RNA RNA 20 ~ 25 nucleotides NT mrna3 RNA 20 RNA 3.1 13 mir- 155 mir - 19a mir - 181b mir - 24 mir - 34a mir-210 mir-16 2.1 s mir- 148b mir - 4093p mir - 801 mir - 21 mir-24 3.2 s 14 25% HER2 2.2 mir-10b mir-105 mir-34a 155 15 P- mir-105 23 ZO-1 1d 16 mir -145 2 ANGPT2 mir - 10b RNA 17 15 G1 G0 19 21 22 HER2 2.3-2B -3B - Ex3-2B mir- 24 141 mir-200 mir-125b mir-15 mir-203 AdVHER2 210 mir-801 mir - 16 mir - 125b HER2 T
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