Advance in Nanorealgar Studies

21 5 2009 5 PROGRESS IN CHEMISTRY Vol. 21 No. 5 May, 2009 1 1 2 3 (1. 430074 ; 2. 430074),,, ;,, : O61316 ; R284 : A : 10052281X(2009) 0520934206 Advance in Nanorealgar Studies Ye Xiaochuan 1 Yang Xiangliang 1 Xu Huibi 2 3 (1. College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China ; 2. College of Chemistry and Chemical Technology, Huazhong University of Science and Technology, Wuhan 430074, China) Abstract Mineral drug realgar has been extensively used in traditional Chinese medicine for a long time. Its therapeutic effects have attracted increasing attentions in recent years. However, the poor bioavailability owing to its poor water2solubility and potential toxicity hamper it from clinical applications. These problems may be improved when realgar is processed using nanotechnology. The pharmacokinetics of arsenic between nanorealgar and fraditionally prepared realgar is notably varied. Based on the studies of our group and other researchers, some aspects of nanorealgar are summarized in the paper, including preparation methods and characterization, pharmacokinetic behavior, mechanism of antitumour activity, active species and Chinese medicinal formulae of nanorealgar. Moreover, the further research trends of nanorealgar are also discussed. Key words nanorealgar ; bioavailability ; pharmacokinetics ; active ingredients ; antitumour effect ; Chinese medicinal formulae Contents 1 Preparation methods and characterization of nanorealgar 2 Pharmacokinetic of nanorealgar 3 Action mechanism of antitumour of nanorealgar 4 Active species of nanorealgar 5 Chinese medicinal formulae of nanorealgar 6 Prospect 6. 1 Hormesis effect of nanorealgar 6. 2 Pharmacokinetics of nanorealgar and its formulae, : 2008 12 ( ) 3 e2mail :hbxu @mail. hust. edu. cn

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