19 2Π3 2007 3 PROGRESS IN CHEMISTRY Vol. 19 No. 2Π3 Mar., 2007 3 1,2 1,3 3 3 3 (1. 730030 ; 2. 730000 ; 3. 730000) : O631 ; TB381 : A : 10052281X(2007) 02Π320362208 Intelligent Drug Delivery System of Intelligent High Polymer Materials Dai Yani 1,2 Li Ping 1,3 3 3 Wang Aiqin 3 (1. The Second Hospital of Lanzhou University, Lanzhou 730030, China ; 2. Pharmacy College of Lanzhou University, Lanzhou 730000, China ; 3. Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China) Abstract The application and development in intelligent drug delivery systems of synthetic intelligent high polymer materials,semisynthetic high polymer materials,and natural intelligent high polymer materials are reviewed. The prospects in intelligent drug delivery system of intelligent high polymer materials are discussed. Key words intelligent high polymer materials ; intelligent drug delivery systems ; synthetic intelligent high polymer materials ; semisynthetic high polymer materials ; natural intelligent high polymer materials 1 5 ], : 21 ph : 3 [1 : 2006 3, : 2006 5 3 (No. LZUYX200625) 3 3 e2mail :gsliping @163. com
2Π3 363 2 2. 1,, PHEMA 2 2 (MAA2 ( g2eg), ) ph Eeckman [15 ] N2 (NIPAAm) 4, ( intelligent drug delivery (LCST) 37 4 LCST system,idds) ( self- regulated drug delivery system,srdds) : (PNIPAAm2co2AAm) 3919 015 ; N2 2N2 2N2 ( PNIPAAm2co2, ; MVA) 3816 014 ; N2 2N2 ( ph ( PNIPAAm2co2NVA) 3816 014 ; ),, N2 222 ( PNIPAAm2 ; co2vpl) 4012 015 [6 ] 10 % ph Na 2 SO 4 11 ] N2, [7 ( PNIPA) (MAA) 222 (HEMA) (AA) Na 2 SO 4 (PVA) (MMA) ( PEG), ( PNIPAAm2co2MVA) ( PNIPAAm2co 2NVA) ( PAAm) ( PVP) 80 % 90 % (DMAEMA) N2 Smart Plug TM [16 ] ( IPN) [12,13 ] 014 mm 1 mm, 9 mm 2 mm, Huang [17 ] N2 2 ( PNIPAAm2co2allylamine) N2 : 2 ( PNIPAAm2co2AA) He [14 ] N2, ph PNIPAAm2co2allylamine 222 ( PHEMA) PEO2PPO2PEO G(AO8) (BSA) : N2 2, 222 ( HEMA), PNIPAAm2co2AA
364 19, (ph = 210) 20 % ph = 714 C 80 % 60 % 80 % ph,3, (ph ) [18 Ramkissoon- Ganorkar 20 ] ph N2 2 1 : 2 (PNIPAAm2co2BMA2co2AA), C ; ; ph, [20 ] 1 phπ Fig. 1 Mechanism of protein drug release from phπthermo2sensitive beads made of polymers with increasing molecular weight(mw) [20 ] PEO ph EUD, 2 p K a ( Eudragit,EUD L100 or EUD S100) ph,, EUD L100 ph = 6, EUD S100 ph = 7 Carelli [21 ] ph 2. 2 ( PEO) ( PACA) 2 Eudragit ( EUD L100 or EUD S100) 1 1 (WΠW) ph ph EUD p K a (p K a > 6) PEO EUD PEO2EUD ; ph EUD (PLA) ( PLGA) p K a, 2 ( PLA2PEG) 2
2Π3 365, Ertl [28 ] D, L2 Yoo [22 ], (PLGA) PLGA ( H2PLGA) ( PLGA), : 20 % 35 % ; 160h 40 % 75 %, PLGA H2PLGA 1 % PLGA P2 Dong Marinina [29 ] [23 ] (D,L2, )Π ( PLGAΠMMT) (VCR) PLGAΠMMT (VBL) VCR ZnSO 4 Π,MMT VCR ; VBL 310nm, 01150 MMT Zhang [30 ] N2, (NIPAAm) :MMT (PGCL) ; MMT, ( OVA), Caco22 HT229 NIPAAmΠPGCL 22 37 57 % 117 % 11 % 55 %, MMT OVA 3, PLGAΠMMT Π PLGAΠMMT [24 Jong 26 ] (PLA) ( CMC) ( EC) (MC),D L2 (HPMC), 2D2 ( dextran2d2 33 lactate) 2L2 ( dextran2l2lactate) ],, Bilati [27 ] D,L2 ( PLGA) [34 ] w(1)πoπw(2) (FITC2BSA),BSA > 80 % D,, Liang [35 ] L2 (MC),pH : Π w(1) CaCl 2 Na 2 HPO 4 NaCl 100 % ; Π, Π 017molΠL [31
366 19 NaCl 32 ph : (BSA) Π 4 37 4. 1 (95 % 98 %) (chitosan) ph = 112, 215 %,BSA (20 %) ; ph = 714, 86 % 41 ] Π [42 ( ) ],, Karavas [36 ] [43 ] (CS) 2 ( 2GP), Π ph (FELOΠPVP) 10 90, 37, Π (PVPΠHPMC) ph VB12, PVPΠ ph HPMC : ph = 410,, 70min 65 % ;ph = 714 Wakerly [37 ] 57 % ph = 410 70 8 h 20 % min 42 % ;ph = 714 8 h 50 % 37 Sangalli [38 ] CSΠGP ph HPMC, Bayramoglu [44 ] ph,hpmc ( IPN) (AIBN) 222 4, ( 22 ph = ) 714,10h 80 %, [39, 100mg 2
2Π3 367 [45 ] 4. 2, [46 ] Lin [49 ] ph (BSA), : (alginate)πn, O2 (NOCC) CaCl 2 (011 013molΠL) ; 1 %BSA (WΠV) alginateπnocc,, CaCl 2 (012molΠL) 30min 37 ; [47 ], CaCl 2 ( PLGA) ph = 112 310 315mm 215 218mm Zeta ; 10u kg - 1,14 16h :alginate NOCC 1 1 (W ( P < 01 05) W) ; alginate2nocc 1514 %, PLGA 77 % ph = 112 ph = 714 : ph = 112 15 % ; ph = 714 PLGA, Zheng [48 ] 80 % ;24h 82 % 87 % (alginate)2 (chitosan)2 alginateπnocc (PLGA) (BSA), 6,alginateΠchitosan Zahoor [50 ] PLGA WΠO ( INH) 31 9 m,bsa 81 % (RIF) ( PZA), INH PZA 87 % PLGA 61 % 65 % 70 % 90 %,RIF 80 % 90 %, PLGA PLGA 23515nm 8015 % BSA Π, 111 014 m, 50 70 30 1171 011 m,24h 24 % 8 %, PLGA 48 % 52 %,24h 15 5 % 2 % ;,, 15
368 19 45,,, Liu [51 ] Π (alginateπhpmc), 2, 8h, 2 [52 ] 4. 3 Fig. 2 Concept of dual2stimuli2responsive drug release by IPN2 structured hydrogel [52 ] ph DNA Kurisawa [52 ] DNA,,DNA ( IPN) DNA 2, DNA 5 ; ( ) [53, 2 ] Π,,, ph ph ; ( ),, ( ) 21 DNA (DDS), Kushibiki [54 ] ( [ 1 ] Kasbyap N, Kumar N, Kumar M N V R. Critical Review in ) Therapeutic Drug Carrier Systems, 2005, 22 (2) : 107 149
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