38 24 2013 12 Vol. 38 Issue 24 December2013 NF-κB 1 2* 3 1 1 1 1. 210029 2. 210029 3. 210008 chronic kidney disease CKD nuclear transcription factor kappa B NF-κB NF-κB CKD NF-κB chronic kidney disease CKD κ κb NF-κB P50 1 P52 P65 c-rel RelB N inflammatory cell macrophage MΦ T RHD DNA p65 p50 2 p65 C NF-κB renal interstitial fbrosis RIF 2 IκB IκB 3 nuclear transcription factor kappa B NF-κB Rel /NF-κB IκB IκBα IκBβ kinases IKK IκB kappab kinases IKK proteinsnf- -α tumor necrosis factor alpha IκBζ IκBε Bcl-3 p100 p105 NF-κB TNF-α transforming growth factor TGF-βl NF-κB NF-κB /IκB interleukin IL IκBα IκB IκB IκB kinases IKK IκB IκBα NF-κB NF-κB IKK NF-κB NF-κB IL- IKKα IKKβ IKKγ / NEMO NF-κB essential modulator IκBα IκBβ IκBα 32 36 IκBβ 1α IL-1β IL-6 IL-8 TNF-α -1 MCP-1 4-6 19 23 IKK IκBα IκBβ 1 NF-κB IL-1 TNF-α TGF 4-5 TAK1 NF-κB CKD IKK IL-1 NEMO TRAF6 1 NF-κB Lys63 47-8 NF-κB TAK1 TAB1 /2 TAK1 IKK 9 TNF-α 2013-06-16 RIP1 TAB2 /3 * E-mailjssunwei@ NEMO TAK1 IKK 10 TGF 163. com E-mailhubeilhliuhong@ 163. com 4246 RIP1 NEMO TRAF2 TRAF5 Akt /PKB IKK IKK IκB NF-κB
38 24 2013 12 Vol. 38 Issue 24 December2013 1 Fig. 1 NF-κB The intervention of Herbs on NF-κB signaling pathway MCP-1 12 4-5 UUO NF-κB NF-κB TGF-βlMCP-1 TNF-α 5-6 11 TGF-β3 TGF- TNF-α IL-1 β1 NF-κB TGF-β1 TGF-β1 ttg IL-1 TNF-α IL-1 TNF-α TGF-β1 extracelluar matrix NF-κB MCP-1 RIF ECM RIF MCP-1 13 MCP-1 NF-κB NF-κB p65 IκBα NF-κB MCP-1 IκBβ NF-κB MCP-1 12-13 NF-κB TNF-α NF-κB /IκB NF-κB TNF-α TNF-α NF-κB MCP-1 NF-κB 14 17-18 PPARγ NF-κB RIF 15 NF-κB TGF-β1 mrna NF-κB 19 IκB NF-κB p65 TGF-β1 MCP-1 TNF-α PPARγ NF-κB p65 TGF-β1 CKD 1 MCP-1 RIF NF-κB p65 MCP-1 ECM RIF 20 2 NF-κB TNF-α CKD NF-κB NF-κB 516 NF-κB NF-κB TNF-α 4247
38 24 2013 12 Vol. 38 Issue 24 December2013 NF-κB NF-κB CKD NF-κB TGF-β1 TNF-α IL NF-κB 31 AGEs NF-κB TGF-β1 TNF-α ROS IκB NF-κB MCP-1 IL CKD NF-κB EGb 3 NF-κB 3. 1 NF-κB p65 IκBa NF-κB NF-κB 4 NF-κB NF-κB P65 3. 2 TNF-α TNF-α -1PIAS1 N p65 /RelA NF-κB p65 DNA NF-κB 21 IκB NF-κB RIF NF-κB TNF-α NF-κB TNF-α NF-κB IκB UUO NF-κB 47 22 NF-κB 34 IL-6 p65 23 TNF-α NF-κB T2DM HBZY-1 GMC 3. 3 TGF-β MCP-1 NF-κB TGF-β1 TGF-β 11 MCP-1 NF-κB DN 24 2 p65 NF-κB MCP-1 NF-κB NF-κB p65 MCP-1 MCP-1 NF-κB p65 DN NF-κB NF-κB adriamycin-induced nephropathy ADRN NF-κB MCP-1 IκBα NF-κB IκB 35 Giunt 36 NF-κB p65 NF-κB MCP-1 NF-κB IκB 25 26 TGF-β TGF-β1 ADRN ADRN NF-κB IgAN TGF-β1 p65 IκBα 37 IgAN NF-κB IκB NF-κB DN 32 membranous nephropathy MN NF-κB p65 TNF-α NF-κB 14 33 NF-κB TNF-α NF-κB p65 TGF-β1 MCP-1 IκBβ IκBα IκBβ NFκB /IκB 27 ADRN NF-κB p65 IκBα 38 NF-κB p65 IκBα DN NF-κB NF-κB MCP-1 39 NF-κB /IκB TGF-β1 NF-κB 28-29 ADRN NF-κB ECM FRNS 40 NF-κB NF-κB MCP-1 NF-κB NF-κB /IκB NF-κB / TNF MCP-1 41 30 GMC GMC TGF-β1 mrna NF-κB 4248
38 24 2013 12 Vol. 38 Issue 24 December2013 42 NF-κB MCP-1 NF-κB CKD 46 Thl /Th2 47 Thy1. 1 NF-κB NF-κB p65 IκB TGF-β1 MCP-1 48 TNF-α TGF-β1 MCP-1 TGF-β1 CKD 1 49-50 IgA nephrin GBM nephrin slit dia-phragmsd nephrin nephrin SD SD nephrin 43-44 Sagair Hussain 45 nephrin NF-κB nephrin NF-κB NF-κB NF-κB CKD 1 Table 1 NF-κB Intervention effect of herbs on NF-κB signaling pathway IgAN NF-κB NF-κB - 37 p65 TGF-β1 MCP-1 TGF-β1 NF-κB 23 HBZY-1 GMC IκB NF-κB - DN ECM 31 2 NF-κB p65 - DM 24 NF-κB TNF-α N- -β-d- 33 RIF 2 IL-6 TNF-α 34 NF-κB NF-κB p65 32 MN ColⅣ NF-κB 30 TGF-β1 mrna NF-κB GMC ECM 41 NF-κB MCP-1 - DN 42 NF-κB p65 IκBα - NF-κB/IκB NF-κB NF-κB/ - IKB TNF NF-κB MCP-1-27 29 - ROS 40 1Vidt D G. 2006 972A 20A. Inflammation in renal diseasej. Am J Cardiol 2 Papayianni A. Cytokinesgrowth factorsand other inflammatory mediators in glomerulonephritisj. Ren Fail1996 18 5 725. 3 Sanz A BSanchez-Nino M DRamos A Met al. NF-kappaB in 4249
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38 24 2013 12 Vol. 38 Issue 24 December2013 Th1 /Th2 -κb J. 20105 357. 45Hussain SRomio LSaleem Met al. Nephrin deficiency acti- 38. NF-κB vates NF-kappaB and promotes glomerular injuryj. J Am Soc MCP-1 J. 20092 102. Nephrol2009 208 1733. 39. UUO 46. IgA NF-κB J. J. 2011 20131 62. 40. 47. J. 20093 186. 200910181580. 8 P. 2010-1-13. 41. 48. smad2 TGF-β1 TGF-β1 mrna NF-κB J. CTGF D. 20106 833. 42. 49. NF-κB MCP-1 J. nephrin podocin J. 2011 20111 48. 43D'Amico GBazzi C. Pathophysiology of proteinuria J. Kidney Int 2003 633 809. 44Huber T BKottgen MSchilling Bet al. Interaction with podocin facilitates nephrin signalingj. J Biol Chem2001 276 4541543. 11974. 2011. 5 546. 50. IgA nephrin podocin J. 20095 458. Regulatory mechanism of NF-κB signaling pathway on renal tissue inflammation in chronic kidney disease and interventional effect of traditional Chinese medicine LIU Hong 1 SUN Wei 2* WAN Yi-gang 3 TU Yue 1 YU Bing-yin 1 HU Hao 1 1. Nanjing University of Chinese Medicine Nanjing 210029China 2. Department of NephrologyJiangsu Provincial Hospital of Chinese MedicineNanjing 210029China 3. Department of Traditional Chinese MedicineNanjing Drum Tower HospitalAffiliated Hospital of Nanjing University Medical SchoolNanjing 210008China AbstractIn chronic kidney disease CKD inflammatory responses during the progression of renal tissue and tissue injury related causes its progression to end-state renal disease. Among themnuclear factor nuclear factornf-κb signaling pathway by regulating the corresponding nuclear expression of target gene transcriptionas well as affecting the synthesis of inflammatory mediators induction of inflammation lead to kidney damage and renal fibrosis. Some single herbs and their extracts such as Astragali Radix Scutellariae RadixGinkgo Foliumand some traditional Chinese medicine such as Danggui Buxue decoctionqilian decoctioncan reduce the inflammatory damage induced by renal tissue NF-κB signaling pathway and delay the progression of CKD. Key wordschronic kidney diseasetraditional Chinese medicinenf-κbsignaling pathway doi10. 4268 /cjcmm20132411 4251