2014 41 7 1351 DOI 10. 13192 / j. issn. 1000-1719. 2014. 07. 015 130117 3 R741 A 1000-1719 2014 07-1351-06 Research on Chinese Medicine Promoting Nerve Regeneration LI Xin MENG Lingyu College of Basic Medical Sciences Changchun University of Chinese Medicine Changchun 130117 Jilin China Abstract Nerve regeneration is neuroscience and clinical research hotspot and difficulty mainly in nerve suture breakage neurotrophic factors tissue engineering stem cells gene therapy to promote nerve regeneration research. Chinese medicine as a treasure of Chinese medicine according to its nerve injury regeneration insights is gradually becoming a hot research to promote nerve regeneration. The current study focused on the compound Chinese medicine single herbs acupuncture and several other key aspects and have achieved good results. The author reviewed the above three aspects of their papers and the recent progress in promoting nerve regeneration that Chinese medicine to promote nerve regeneration has good prospects for development. Key words nerve regeneration medicine acupuncture progress 3 3 MS 2 MS MS 1 2 3 4 3 3 MS 1 2 1. J. 2008 28 2 90-91. 2014-01 - 18 2. J. 2007 201210199010 5 5-7. 1979-3. J. 2002 16 5-6 347-350.
1352 2014 41 7 10 11 Bcl - 2 /Bax 12 bfgf NGF AKT /PKB VEGF Flk - 1 13-16 17 18 1. 2 TGF - β TGF - β 19 1 1. 1 AchE 70 HSP70 14 MBP 1 EAE GAP - 43 MAP - 2-200 NF - 200 20-22 Wang L 23 Yang S 2 H 2 O 2 600 μg /ml 1 h H 2 O 2 12 h MDA Nogo A Wang L 3 1. 3 / / - 1 / - 2 / Chen A 4 RN SCI SCI 5 6-24 7 middle cerebral artery occlusion MCAO DPN NSCs MCAO NSCs SDF - 1 L4-6 NR2B 8 DRG pnf - H 25 26 9 32 23 5 1 3 VEGF 90. 63%
2014 41 7 1353 27 A A AMPK 2 LKB1 A 2. 1 Yang XY 47 NSC BMSC A AGEs enos Yu NSE XY 48 B - 2 MAP - 2 5 ~ 25 mg /kg GFAP 28 Nestin Lin YH 49 B β - B 29 BPRP 30 B BPRP NCAM c - fos 31 NSC NSC NGFmRNA NSC NGF 50 32 6 - SOD MDA Ca 2 + Caspase - 3 33 51 ⅡA TanⅡA Cheng CY 34 50 mmol CA1 L - Ca 2 + mrna Ca 2 + 52 200 mmol 53 2. 2 2 μmol /L Rg1 Rg1 SVZ 35 Rg1 NSC Hes1 SVZ 36 Rb1 Rb3 Rg1 54 NSC 37 Rg1 Rb1 2. 5 38 Ma J 39 Rg1 EGb Rg1 Lu ZF 40 Rg1 Cheng B 55 GBE 2. 3 1 6 24 48 h 1 6 24 48 h Caspase SOD GSH - Px Jahanshahi M 56 NOS MDA 41 MCAO VEGF 42 Zhao L 57 BDNF EGB761 bfgf 43 Smith 58 EGb PC12 NSC 44 GFAP EGb 45 2. 4 Jeong JB 46 PGC - 1α SIRT3 nnos C C A SALA 59 EGb761
1354 2014 41 7 2. 6 Hoang NS 80 Moon YJ 62 ADR 5 ~ 6 - α TNF - α - 1β IL - 1β - 6 IL - 6 81 HRP inos - 2 COX - 2 LPS BV2 82 plxsn - EGFP ADR p38 SVZ NSC pronerve SVZ NSC ADR Caspase - 3 83 4 ADR Zheng P 63 84-43 GAP - 43 mrna mrna 64 GAP - 43 mrna 85 FeSO 4 H 2 O 2 α7nachr MCAO 65 STAT5 2 h SD 3 ~ 4 h 5 ~ 6 h 3 d NCAM 66 250 g /L 8 ml /kg 86 2. 7 67 68 69 70 71 1. M. 1966 31 - G - 90 72 35. 2 Yang S Gao Q Xing S et al. Neuroprotective effects of Buyang Huanwu decoction against hydrogen peroxide induced oxidative injury in MAPK Schwann cells J. J Ethnopharmacol 2011 137 3 1095-1101. PA MMP2 /9 3 Wang L Jiang DM. Neuroprotective effect of Buyang Huanwu Decoction on spinal ischemia /reperfusion injury in rats J. J Ethnopharma- PI3K /Akt G1 col 2009 124 2 219-223. D1 cyclin E cyc- 4 Chen A Wang H Zhang J et al. BYHWD rescues axotomized neurons lin A Bcl2 60 61 EGb inos Bcl - 2 Caspases - 3 Bax 73 EGb 2. 8 3 ~ 7 d 74 75 76 77 78 79 3
2014 41 7 1355 and promotes functional recovery after spinal cord injury in rats J. J Ethnopharmacol 2008 117 3 451-456. 5. 24. DPN NGF mrna J. 2012 39 4 J. 2012 4 31-33. 936-940. 25. 6. J. 2012 23 2031-2034. J. 2009 24 5 26. 32 J. 678-680. 2013 3 37-38. 7. 27. J. 2012 18 6 159-162. 8. 28. J. 1997 17 111-112. J. 2007 30 5 534. 9. 29. Flk1 J. 2007 38 3 J. 2012 25 3 394-397. 192-195. 10. 30. J. 2010 18 3 193-198. 11. 31. J. 2010 J. 2012 28 4 373-377. 41 1 53-56. 32. 12. J. 2009 40 5 754. J. 2005 15 6 363. 33 Chan WS Durairajan SS Lu JH et al. Neuroprotective effects of as- 13. tragaloside IV in 6 - hydroxydopamine - treated primary nigral cell J. 2008 15 culture J. Neurochem Int 2009 55 6 414. 1 9. 34 Cheng CY Yao CH Liu BS et al. The role of astragaloside in regen- 14. eration of the peripheral nerve system J. J Biomed Mater Res A NGF PI3K /AKT J. 2006 76 3 463-469. 2008 15 1 24. 15. J. 2011 6 12 1021-1023. J. 2009 6 36. Rg1 14 33. J. 2009 34 4 443. 16 Cai G Liu B Liu W et al. Buyang huanwu decoction can improve recovery of neurological function reduce infarction volume stimulate neural proliferation and modulate VEGF and Flk1 expressions in 2004 21 3 231. transient focal cerebral ischaemic rat brains J. J Ethnopharmacol 38. Rg1 Rb1 2007 113 2 292. STAT3 17 Hsieh CL Liu TH Lin JG et al. The relationship between Bu - Yang J. 2007 15 3 172. - Huan - Wu - Tang improve cerebral infarct and regulation of Ni- 39 Ma J Li W Tian R Neurosci Lett al. Ginsenoside Rg1 promotes tric oxide in ischemia - reperfusion rats J. Taiwanese Journal of peripheral nerve regeneration in rat model of nerve crush injury J. Chinese Medicine 2004 3 20-35. Neuroscience Letters 2010 478 2 66-71. 18 Wang XL. Experimental research on Bu Yang Huan Wu Tang's effect 40 Lu ZF Shen YX Zhang P et al. Ginsenoside Rg1 promotes proliferation and neurotrophin expression of olfactory ensheathing cells J. J on peripheral nerve regeneration J. Journal of Shandong Medical U- niversity 1999 37 41-43. Asian Nat Prod Res 2010 12 4 265-72. 19 Li HM Gao X Yang ML et al. Effects of Zuogui Wan on neurocyte 41. apoptosis and down - regulation of TGF - beta1 expression in nuclei J. of arcuate hypothalamus of monosodium glutamate - liver regeneration 2012 23 3 536-538. rats J. World J Gastroenterol 2004 10 19 2823-2826. 42. 20. J. 2008 15 HSP70 J. 2009 29 6 329. 2 161. 43. BDNF bf- 21. - 43 GF J. - 2 J. 2007 28 2008 39 2 207. 6 748. 44. 22. J. J. 2007 28 2 142. 2008 14 4 42. 23 Wang L Zhao H Fan YP Research on the mechanism of Zuogui Pill and Yougui Pill in promoting axonal regeneration in model rats of autoimmune encephalomyelitis J. Chin J Integr Med 2010 16 2 167-172. J. 2011 45 1 75-78. J. 2009 30 7 580. 35. Rg1 37. Rb1 Rb3 Rg1 J. 45. GFAP J. 2009 25 4 427.
1356 2014 41 7 46. 66 Lin Li Liu Xijing Rong Xia et al. Angelica on hypoxic ischemic J. 2007 11 7 brain damage of juvenile rat neuron protective effect of J. Sichuan 1225. 47 Yang XY Sun L Xu P et al. Effects of salvianolic acid A on plantar microcirculation and peripheral nerve function in diabetic rats J. Eur J Pharmacol 2011 665 1-3 40-46. 48 Yu XY Lin SG Zhou ZW et al. Tanshinone IIB a primary active constituent from Salvia miltiorrhza exhibits neuro - protective activity in experimentally stroked rats J. Neurosci Lett 2007 417 3 261-265. 49 Lin YH Liu AH Wu HL et al. Salvianolic acid B an antioxidant from Salvia miltiorrhiza prevents Abeta 25-35 - induced reduction in BPRP in PC12 cells J. Biochem Biophys Res Commun 2006 348 2 593-599. 50. J. Evidence - Based Complementary and Alternative Medicine J. 2011 46 16 1245-1248. 2004 1 345-348. 51. ⅡA 71 W Hu T Fu. Isolation and properties of a novel fibrinolytic enzyme J. 2009 20 1 82. from an earth worm J. Zhong Yao Cai 1997 20 2 78-81. 52. 72 EL Cooper T M Hrzenjak M Grdisa. Alternative sources of fibrinolytic anticoagulative antimicrobial and anti - cancer molecules J. J. 2012 34 4 731-733. In- 53. ternational Journal of Immunopathology and Pharmacology 2004 17 J. 2011 40 7 774-775. 3 237-244. 54 Smith J Burdick AJ Golik P et al. Anti apoptotic properties of ginkgo biloba extract EGb761 in differentiated PC12 cells J. Cell Mol Biol Noisy le grand 2002 48 6 699-707. 55 Cheng B Wang W Lin L et al. The change of the spinal cord ischemia - reperfusion injury in mitochondrial passway and the effect of the Ginkgo biloba extract's preconditioning intervention J. Cell Mol Neurobiol 2011 31 3 415-420. 56 Jahanshahi M Nikmahzar E Yadollahi N et al. Protective effects of Ginkgo biloba extract EGB 761 on astrocytes of rat hippocampus after exposure with scopolamine J. Anat Cell Biol 2012 45 2 92-96. 57 Zhao L Liu Q Chen H et al. The effect of 2 5 - hexanedione on myelin protein zero expression and its mitigation using Ginkgo biloba extract J. Biomed Environ Sci 2011 24 4 374-382. 58. 3 205. EGb761 J. 2002 78. 29 4 252. J. 2007 27 3 173. 59. 79. - J. 2002 18 1 46. J. 2009 38 4 424. 60. 80 Hoang NS Sar C Valmier J et al. Electro - acupuncture on functional peripheral nerve regeneration in mice a behavioural study J. J. 2007 17 9 675-679. BMC Complement Altern Med 2012 12 141. 61. 81. J. J. 2012 18 9 147-1988 13 4 358. 150. 82. plxsn - EGFP 62 Moon YJ Lee JY Oh MS et al. Inhibition of inflammation and oxidative stress by Angelica dahuricae radix extract decreases apoptotic cell death and improves functional recovery after spinal cord injury J. J Neurosci Res 2012 90 1 243-256. 63 Zheng P Zhang J Liu H et al. Angelica injection reduces cognitive impairment during chronic cerebral hypoperfusion through brain - derived neurotrophic factor and nerve growth factor J. Curr Neurovasc Res 2008 5 1 13-20. 64. STAT - 5 J. 2011 J. 2006 21 2 114-117. journal anatomy 2010 18 4 13-15. 67 S Wei P Zhang Y Dang et al. Primary study on effect of various components of modified formula radix hedysari on peripheral nerve regeneration J. Zhongguo Xiufu Chongjian Waike Zazhi 2008 22 9 1056-1059. 68 EL Cooper. CAM ecam bioprospecting the 21st century pyramid J. Evidence - Based Complementary and Alternative Medicine 2005 2 2 125-127. 69 EL Cooper. Complementary and alternative medicine when Rigorous can be science J. Evidence - Based Complementary and Alternative Medicine 2004 1 1-4. 70 S Matsuba. Complementary and alternative approaches to biomedicine 73 Yung - Ming Chang Wei - Yi Chi Tung - Yuan Lai. Dilong Role in Peripheral Nerve Regeneration J. Evid Based Complement Alternat Med 2011 2011 380809. 74. Ca 2 + J. 2009 27 1 99. 75. β 1-40 J. 2007 32 13 1336. 76. J. 2007 23 3 358. 77. J. 2005 85 MCAO SVZ NSC J. 2010 28 1 10-12. 83. SFI J. 1998 18 4 249. 84. - 43mRNA J. 2003 7 22 3064-5. 85. 17 4 425-426. 65. 86. J. 2010 18 4 13-15. J. 2010 16 12 197-201.