Supplementary Methods Immunohistochemistry Five-micrometer-thick sections of formalin-fixed, paraffin-embedded tissue specimens were deparaffinized and dehydrated. All sections were incubated with anti-human ANXA2 rabbit polyclonal antibody (Abcam, Cambridge, UK; dilution 1:1000) and anti-human MSH2 mouse monoclonal antibody (FE11, Dako, Carpinteria, CA; dilution 1:200). Before incubation, the sections were heated for 10 min at 120 o C in an autoclave using sodium citrate buffer at ph 6 and ph 9 (Dako), respectively, for antigen retrieval. Non-specific reactions were blocked with Antibody Diluent (Dako). Both primary antibody incubations were conducted at 4 o C overnight, followed by incubation with EnVision+ Dual link system-hrp (Dako) at room temperature for 30 min. 3.3'-Diaminobenzidine tetrahydrochloride was used as the chromogen. All sections were counterstained with hematoxylin. As a negative control, the primary antibodies were omitted from the reaction sequence. Tissue specimens of T and N samples showing the highest levels of ANXA2 and MSH2 protein expression by the 2DICAL method served as positive controls in all analyses, respectively.
VHL (Ch 3, 10188195) Case A57 VHL (Ch 3, 10183770) Case B1 VHL (Ch 3, 10191526) Case A52 VHL (CH 3, 10191528) Case B3 N SNV: A>G SNV: T>A InserKon: T DeleKon: A T PBRM1 (Ch 3, 52643537) Case A42 TNN (Ch 2, 179401665) Case A43 KDM5C (Ch X, 53225122) Case A85 KDM5C (Ch X, 53228329) Case A58 N DeleKon: TT DeleKon: A SNV: C>T DeleKon: T T BAP1 (Ch 3, 52442622) Case A73 BAP1 (Ch 3, 52437801) Case A61 SETD2 (Ch 3, 47163247) Case A69 SETD2 (Ch 3, 47103722) Case B1 N SNV: C>A DeleKon: TT DeleKon: TT DeleKon: GCA T WDFY3 (Ch 4, 85701438) Case A42 WDFY3 (Ch 4, 85699703) Case A50 NCOA1 (Ch 2, 24930178) Case A43 PLCE1 (Ch 10, 96058292) Case B8 N SNV: A>G InserKon: G SNV: C>T SNV: A>T T PARP8 (Ch 5, 50117140) Case B4 CD6 (Ch 11, 60774065) Case B2 CELSR2 (Ch 1, 109815841) TNFSF11 (Ch 13, 43180773) Case B4 Case B3 N SNV: A>G SNV: C>T SNV: C>T DeleKon: A T Supplementary Figure S1. VerificaKon of representakve genekc aberrakons described in Table 2 by Sanger sequencing. RepresentaKve electrophoretogram for Sanger sequencing of the VHL, PBRM1, TNN, KDM5C, BAP1, SETD2, WDFY3, NCOA1, PLCE1, PARP8, CD6, CELSR2 and TNFSF11 genes. PosiKon numbers of the mutakon start site are those based on the NaKonal Center for Biotechnology InformaKon Database Genome Build 37). Ch, chromosome.
A B C D Supplementary Figure S2. Representa)ve photos of immunohistochemical examina)ons for ANXA2 (A and B) and MSH2 (C and D) in N (A and C) and T (B and D) samples. These examina)ons were performed as described in Supplementary Methods. (A) Immunoreac)vity for ANXA2 was localized only at the apical membrane of a few proximal tubules, which are the origin of clear cell RCCs, the distal tubules and glomeruli in N samples. (B) Almost all cancer cells showed strong immunoreac)vity for ANXA2 in the circumferen)al cell membrane and cytoplasm in T samples. (C) Almost all epithelial cells showed strong nuclear immunoreac)vity for MSH2 in N samples. (D) Almost all cancer cells lacked immunoreac)vity for MSH2 in T samples. Thus, elevated expression of ANXA2 protein and reduced expression of MSH2 protein were verified immunohistochemically in T samples rela)ve to N samples, indica)ng the reliability of two- dimensional image- converted liquid chromatography- mass spectrometry analysis.
mrna expression level (/GAPDH) 20 18 16 14 12 10 8 6 4 2 0 AURKA P=4.225x10-4 250 P=2.100x10-4 20 P=9.448x10-4 CIMP (-) CIMP (+) 200 150 100 50 0 AURKB CIMP (-) CIMP (+) 18 16 14 12 10 8 6 4 2 0 BIRC5 CIMP (-) CIMP (+) 8 BUB1 CDC20 NEK2 SPC25 P=5.120x10-4 35 P=1.668x10-4 16 P=5.052x10-4 25 P=5.891x10-3 mrna expression level (/GAPDH) 7 6 5 4 3 2 1 0 CIMP (-) CIMP (+) 30 25 20 15 10 5 0 CIMP (-) CIMP (+) 14 12 10 8 6 4 2 0 CIMP (-) CIMP (+) 20 15 10 5 0 CIMP (-) CIMP (+) Supplementary Figure S3. Levels of mrna expression for genes included in the top pathway Cell cycle: The metaphase checkpoint in CpG island methylator phenotype (CIMP)- negasve renal cell carcinomas (RCCs) (n=74) and CIMP- posisve RCCs (n=19 in the inisal and validason cohorts) evaluated by quanstasve reverse transcripson- PCR analysis. Average levels of mrna expression for AURKA, AURKB, BIRC5, BUB1, CDC20, NEK2 and SPC25 in CIMP- posisve RCCs were significantly higher than those in CIMP- negasve RCCs (Mann- Whitney U test). -, CIMP- negasve RCCs; +, CIMP- posisve RCCs. Error bars, standard error. P values of <0.05 are underlined.
Arai E, et al. Supplementary Table S1. Probe and primer sets used for TaqMan Gene Expression Assays for quantitative RT-PCR Gene AURKA AURKB AURKC BIRC5 BUB1 CDC20 NEK2 SPC25 GAPDH Probe and primer set Hs01582072_m1 (Life Technologies) Hs00945858_g1 (Life Technologies) Hs04184903_g1 (Life Technologies) Hs04194392_s1 (Life Technologies) Hs01557701_m1 (Life Technologies) Hs00426680_mH (Life Technologies) Hs00601227_mH (Life Technologies) Hs00221100_m1 (Life Technologies) Hs02758991_g1 (Life Technologies)
Supplementary Table S2. All detected genetic aberrations (non-synonymous single nucleotide mutations [SNVs] and insertions and deletions [indels]) in each renal cell carcinoma (RCC) SNVs Gene KLHL17 chr1 896848 896849 T C exonic NM_198317:c.T284C:p.V95A AGRN chr1 982804 982805 G A exonic NM_198576:c.G3487A:p.G1163R AGRN chr1 985942 985943 G A exonic NM_198576:c.G5113A:p.D1705N B3GALT6 chr1 1168160 1168161 C T exonic NM_080605:c.C503T:p.A168V MXRA8 chr1 1289815 1289816 C G exonic NM_032348:c.G1023C:p.Q341H SLC35E2B chr1 1602965 1602966 G T exonic NM_001110781:c.C689A:p.S230Y PEX10 chr1 2340109 2340110 C A exonic NM_002617:c.G381T:p.L127F PLCH2 chr1 2411364 2411365 C T exonic NM_014638:c.C464T:p.A155V MMEL1 chr1 2523067 2523068 C T exonic stopgain SNV NM_033467:c.G2168A:p.W723X PRDM16 chr1 3319384 3319385 A G exonic NM_022114:c.A707G:p.D236G PRDM16 chr1 3342157 3342158 G T exonic NM_022114:c.G2953T:p.D985Y TP73 chr1 3599672 3599673 A G exonic NM_001204184:c.A115G:p.N39D LRRC47 chr1 3701745 3701746 A C exonic NM_020710:c.T1099G:p.C367G C1orf174 chr1 3806614 3806615 G C exonic NM_207356:c.C641G:p.S214C AJAP1 chr1 4829944 4829945 G C exonic NM_001042478:c.G862C:p.V288L ICMT chr1 6285228 6285229 T C exonic NM_012405:c.A766G:p.I256V ESPN chr1 6501108 6501109 G A exonic NM_031475:c.G974A:p.R325H NOL9 chr1 6592795 6592796 T C exonic NM_024654:c.A1262G:p.D421G DNAJC11 chr1 6705149 6705150 G A exonic stopgain SNV NM_018198:c.C931T:p.Q311X PER3 chr1 7869981 7869982 C A exonic stopgain SNV NM_016831:c.C1269A:p.Y423X PER3 chr1 7886688 7886689 C T exonic stopgain SNV NM_016831:c.C2083T:p.R695X SLC2A5 chr1 9100023 9100024 C T exonic stopgain SNV NM_003039:c.G720A:p.W240X H6PD chr1 9305360 9305361 A T exonic NM_004285:c.A368T:p.D123V KIF1B chr1 10434458 10434459 T A exonic NM_015074:c.T4894A:p.L1632M CASZ1 chr1 10699686 10699687 G T exonic NM_001079843:c.C4592A:p.T1531K C1orf127 chr1 11008314 11008315 C G exonic NM_001170754:c.G1877C:p.R626P MTOR chr1 11174394 11174395 A C exonic NM_004958:c.T7280G:p.L2427R MTOR chr1 11174419 11174420 C T exonic NM_004958:c.G7255A:p.E2419K MTOR chr1 11186782 11186783 G T exonic NM_004958:c.C6422A:p.P2141Q MTOR chr1 11217230 11217231 A G exonic NM_004958:c.T4447C:p.C1483R MTOR chr1 11217317 11217318 G A exonic NM_004958:c.C4360T:p.H1454Y MTOR chr1 11217321 11217322 T G exonic NM_004958:c.A4356C:p.K1452N ANGPTL7 chr1 11253820 11253821 T A exonic NM_021146:c.T662A:p.V221E ANGPTL7 chr1 11254984 11254985 C T exonic NM_021146:c.C946T:p.H316Y PTCHD2 chr1 11561451 11561452 C T exonic NM_020780:c.C403T:p.R135W PTCHD2 chr1 11596717 11596718 C A exonic NM_020780:c.C4154A:p.P1385H MIIP chr1 12081828 12081829 G C exonic NM_021933:c.G46C:p.E16Q VPS13D chr1 12318030 12318031 G T exonic NM_015378:c.G981T:p.L327F VPS13D chr1 12343083 12343084 T C exonic NM_015378:c.T4925C:p.L1642P FHAD1 chr1 15708580 15708581 T A exonic NM_052929:c.T4014A:p.D1338E DNAJC16 chr1 15860764 15860765 A T exonic NM_015291:c.A201T:p.E67D AGMAT chr1 15909720 15909721 T A exonic NM_024758:c.A442T:p.I148F C1orf64 chr1 16332838 16332839 T C exonic stoploss SNV NM_178840:c.T508C:p.X170Q ATP13A2 chr1 17326552 17326553 G A exonic NM_001141973:c.C977T:p.A326V PADI2 chr1 17395720 17395721 G A exonic NM_007365:c.C1816T:p.P606S PAX7 chr1 19018333 19018334 A T exonic NM_001135254:c.A673T:p.T225S UBR4(NM_020765:exon80 :c.11892+1g>t) chr1 19437234 19437235 C A sp UBR4 chr1 19511717 19511718 T A exonic stopgain SNV NM_020765:c.A1813T:p.K605X KIAA0090 chr1 19566905 19566906 G A exonic NM_015047:c.C671T:p.S224F PQLC2 chr1 19653833 19653834 C G exonic NM_001040125:c.C732G:p.S244R EIF4G3 chr1 21177918 21177919 C T exonic NM_003760:c.G3436A:p.A1146T EIF4G3 chr1 21186954 21186955 T C exonic NM_003760:c.A2999G:p.H1000R ECE1 chr1 21560131 21560132 T C exonic NM_001113347:c.A1553G:p.Y518C CDC42 chr1 22404987 22404988 G A exonic NM_001791:c.G17A:p.C6Y ZBTB40 chr1 22834538 22834539 A C exonic NM_014870:c.A1406C:p.Y469S ZBTB40 chr1 22848040 22848041 C T exonic NM_014870:c.C3101T:p.A1034V EPHA8 chr1 22903153 22903154 A T exonic stopgain SNV NM_001006943:c.A604T:p.K202X EPHB2 chr1 23191702 23191703 C T exonic NM_004442:c.C1301T:p.A434V ZNF436 chr1 23688999 23689000 T C exonic NM_030634:c.A875G:p.D292G ASAP3 chr1 23756349 23756350 T A exonic stoploss SNV NM_001143778:c.A2684T:p.X895L E2F2 chr1 23848404 23848405 G A exonic NM_004091:c.C502T:p.R168C TCEB3 chr1 24077496 24077497 G C exonic NM_003198:c.G480C:p.R160S HMGCL chr1 24140692 24140693 T G exonic NM_000191:c.A484C:p.I162L GRHL3 chr1 24668670 24668671 C A exonic NM_001195010:c.C976A:p.L326M MAN1C1 chr1 25944580 25944581 G A exonic NM_020379:c.G293A:p.S98N SH3BGRL3 chr1 26607346 26607347 G T exonic NM_031286:c.G140T:p.R47M UBXN11 chr1 26608896 26608897 A T exonic NM_001077262:c.T1096A:p.C366S UBXN11 chr1 26624484 26624485 C G exonic NM_145345:c.G169C:p.V57L ARID1A chr1 27101241 27101242 T A exonic stopgain SNV NM_006015:c.T4524A:p.Y1508X MAP3K6 chr1 27682883 27682884 G T exonic NM_004672:c.C3632A:p.P1211H SESN2 chr1 28599938 28599939 G T exonic NM_031459:c.G821T:p.R274L SRSF4 chr1 29475639 29475640 C A exonic NM_005626:c.G767T:p.R256L PTPRU chr1 29650199 29650200 C T exonic NM_001195001:c.C4003T:p.R1335W PEF1 chr1 32098861 32098862 C T exonic NM_012392:c.G379A:p.D127N COL16A1 chr1 32148550 32148551 C T exonic NM_001856:c.G2522A:p.S841N COL16A1(NM_001856:exo n32:c.2053-1g>t) chr1 32150231 32150232 C A sp TSSK3 chr1 32829543 32829544 T G exonic NM_052841:c.T494G:p.L165R S100PBP chr1 33292308 33292309 T A exonic NM_001017406:c.T609A:p.N203K FNDC5;FNDC5 chr1 33329352 33329353 T C NM_001171940:c.A307G:p.I103V TRIM62 chr1 33613266 33613267 G T exonic NM_018207:c.C939A:p.D313E PHC2 chr1 33797883 33797884 T C exonic NM_004427:c.A275G:p.Y92C CSMD2 chr1 34080169 34080170 C T exonic NM_052896:c.G5947A:p.G1983S CSMD2 chr1 34166248 34166249 C T exonic NM_052896:c.G3481A:p.A1161T C1orf216 chr1 36181410 36181411 T C exonic NM_152374:c.A512G:p.H171R CLSPN chr1 36214198 36214199 T C exonic NM_001190481:c.A2087G:p.D696G EIF2C1 chr1 36367627 36367628 C G exonic NM_012199:c.C1220G:p.T407R THRAP3 chr1 36754994 36754995 G A exonic NM_005119:c.G1375A:p.A459T OSCP1 chr1 36904435 36904436 G T exonic NM_145047:c.C188A:p.S63Y MYCBP chr1 39332616 39332617 C G exonic NM_012333:c.G202C:p.E68Q AKIRIN1 chr1 39466682 39466683 T A exonic NM_024595:c.T401A:p.L134H MACF1 chr1 39751003 39751004 A G exonic NM_012090:c.A1310G:p.Q437R MACF1 chr1 39782070 39782071 C A exonic NM_012090:c.C3473A:p.T1158K PABPC4 chr1 40038183 40038184 C T exonic NM_001135653:c.G268A:p.D90N NT5C1A chr1 40124820 40124821 G A exonic NM_032526:c.C1079T:p.P360L NT5C1A chr1 40131829 40131830 T A exonic NM_032526:c.A214T:p.T72S TRIT1 chr1 40318532 40318533 T A exonic NM_017646:c.A430T:p.T144S ZMYND12 chr1 42915707 42915708 C G exonic NM_032257:c.G133C:p.D45H YBX1 chr1 43166459 43166460 C T exonic NM_004559:c.C749T:p.P250L YBX1 chr1 43166516 43166517 A T exonic NM_004559:c.A806T:p.D269V SZT2 chr1 43888209 43888210 G A exonic NM_015284:c.G1829A:p.C610Y SZT2 chr1 43903309 43903310 C T exonic NM_015284:c.C6164T:p.A2055V IPO13 chr1 44415408 44415409 G A exonic NM_014652:c.G405A:p.M135I B4GALT2 chr1 44451041 44451042 G A exonic stopgain SNV NM_001005417:c.G833A:p.W278X BEST4 chr1 45250599 45250600 G A exonic stopgain SNV NM_153274:c.C970T:p.Q324X PTCH2 chr1 45292708 45292709 C G exonic NM_001166292:c.G2560C:p.E854Q PTCH2 chr1 45293232 45293233 C A exonic stopgain SNV NM_001166292:c.G2212T:p.E738X EIF2B3 chr1 45341312 45341313 C A exonic NM_001166588:c.G1030T:p.A344S HECTD3 chr1 45476589 45476590 C T exonic NM_024602:c.G340A:p.G114S GPBP1L1 chr1 46094020 46094021 G T exonic NM_021639:c.C1332A:p.F444L TSPAN1 chr1 46651185 46651186 T A exonic NM_005727:c.T707A:p.L236Q C1orf190 chr1 46685728 46685729 A G exonic NM_001013615:c.A557G:p.D186G ATPAF1 chr1 47124384 47124385 C T exonic NM_001042546:c.G469A:p.V157M KIAA0494 chr1 47183706 47183707 C T exonic NM_014774:c.G53A:p.R18Q AGBL4 chr1 49000572 49000573 T A exonic NM_032785:c.A1380T:p.E460D ELAVL4 chr1 50666503 50666504 C G exonic NM_021952:c.C797G:p.P266R ZCCHC11 chr1 52943485 52943486 G T exonic NM_001009881:c.C1917A:p.F639L FAM159A chr1 53122676 53122677 G C exonic NM_001042693:c.G538C:p.V180L ECHDC2 chr1 53373600 53373601 C G exonic NM_001198961:c.G303C:p.Q101H GLIS1 chr1 54059823 54059824 A G exonic NM_147193:c.T752C:p.I251T SSBP3 chr1 54717339 54717340 C A exonic NM_001009955:c.G519T:p.M173I HEATR8 chr1 55118846 55118847 C G exonic NM_001039464:c.C248G:p.P83R HEATR8 chr1 55175838 55175839 G T exonic NM_001039464:c.G3951T:p.W1317C TTC4 chr1 55194077 55194078 G C exonic NM_004623:c.G654C:p.Q218H TMEM61 chr1 55457606 55457607 C T exonic NM_182532:c.C464T:p.A155V PCSK9 chr1 55529197 55529198 G A exonic NM_174936:c.G2020A:p.A674T TM2D1 chr1 62149150 62149151 C T exonic NM_032027:c.G581A:p.S194N INADL chr1 62288712 62288713 A G exonic NM_176877:c.A1780G:p.T594A CACHD1 chr1 65113537 65113538 A G exonic NM_020925:c.A1058G:p.N353S RAVER2 chr1 65280517 65280518 G C exonic NM_018211:c.G1885C:p.A629P DNAJC6 chr1 65851519 65851520 G A exonic NM_014787:c.G755A:p.R252H MIER1 chr1 67437361 67437362 A C exonic NM_001077701:c.A790C:p.N264H WLS chr1 68697974 68697975 C T exonic NM_001002292:c.G8A:p.G3E DEPDC1 chr1 68948410 68948411 A C exonic NM_001114120:c.T1080G:p.D360E LRRIQ3 chr1 74507247 74507248 G T exonic NM_001105659:c.C1367A:p.A456D LRRIQ3 chr1 74507426 74507427 T A exonic NM_001105659:c.A1188T:p.K396N C1orf173 chr1 75037162 75037163 T C exonic NM_001002912:c.A4231G:p.S1411G C1orf173 chr1 75055468 75055469 C A exonic NM_001002912:c.G2022T:p.E674D C1orf173 chr1 75065593 75065594 A G exonic NM_001002912:c.T1511C:p.V504A CRYZ chr1 75184934 75184935 A G exonic NM_001130043:c.T386C:p.I129T CRYZ chr1 75188907 75188908 T C exonic NM_001130043:c.A158G:p.Y53C SLC44A5(NM_001130058: exon5:c.53-1g>t,nm_152697:exon5:c.53-1g>t) Chromosome Reference sequence Altered sequence chr1 75805315 75805316 C A sp Functions Amino acid changes ASB17 chr1 76387945 76387946 A G exonic NM_080868:c.T500C:p.L167P ST6GALNAC3 chr1 77093221 77093222 A G exonic NM_152996:c.A709G:p.M237V PIGK chr1 77626990 77626991 T C exonic NM_005482:c.A802G:p.M268V ZZZ3 chr1 78041894 78041895 C T exonic NM_015534:c.G2189A:p.S730N ZZZ3 chr1 78097876 78097877 G A exonic NM_015534:c.C1163T:p.T388I DNASE2B chr1 84880272 84880273 C T exonic stopgain SNV NM_058248:c.C184T:p.R62X LPAR3 chr1 85331623 85331624 T A exonic NM_012152:c.A180T:p.K60N SYDE2 chr1 85624877 85624878 G T exonic NM_032184:c.C3140A:p.S1047Y BCL10 chr1 85733395 85733396 C A exonic NM_003921:c.G616T:p.D206Y CLCA1 chr1 86965594 86965595 C T exonic NM_001285:c.C2612T:p.P871L LRRC8D chr1 90399709 90399710 G A exonic NM_001134479:c.G1083A:p.M361I ZNF326 chr1 90470740 90470741 G A exonic NM_182975:c.G147A:p.M49I ZNF644 chr1 91405913 91405914 G A exonic stopgain SNV NM_201269:c.C997T:p.Q333X ZNF644 chr1 91406215 91406216 A G exonic NM_201269:c.T695C:p.L232S HFM1 chr1 91742191 91742192 C T exonic NM_001017975:c.G3581A:p.R1194H TGFBR3 chr1 92181877 92181878 T A exonic NM_001195683:c.A1778T:p.N593I BRDT chr1 92442923 92442924 A T exonic NM_001242807:c.A805T:p.N269Y GLMN chr1 92757015 92757016 T C exonic NM_053274:c.A244G:p.K82E GFI1 chr1 92941734 92941735 C T exonic NM_001127215:c.G1120A:p.G374S BCAR3 chr1 94047928 94047929 G T exonic NM_003567:c.C1615A:p.R539S ARHGAP29 chr1 94643612 94643613 G T exonic NM_004815:c.C2591A:p.S864Y ABCD3 chr1 94955336 94955337 A C exonic NM_002858:c.A1214C:p.K405T PTBP2 chr1 97250797 97250798 A G exonic NM_021190:c.A892G:p.T298A DPYD chr1 97658730 97658731 T A exonic NM_000110:c.A2516T:p.Y839F FRRS1 chr1 100183026 100183027 G A exonic NM_001013660:c.C1175T:p.A392V VCAM1 chr1 101203762 101203763 T A exonic NM_080682:c.T1868A:p.M623K COL11A1 chr1 103343698 103343699 G A exonic NM_080630:c.C4949T:p.T1650I COL11A1 chr1 103468316 103468317 G T exonic NM_080630:c.C1681A:p.P561T RNPC3 chr1 104093577 104093578 G C exonic NM_017619:c.G1377C:p.L459F PRMT6 chr1 107599700 107599701 G C exonic NM_018137:c.G364C:p.E122Q FAM102B chr1 109103110 109103111 G T exonic NM_001010883:c.G61T:p.V21L STXBP3 chr1 109342860 109342861 T G exonic stopgain SNV NM_007269:c.T1469G:p.L490X AKNAD1 chr1 109358815 109358816 A T exonic NM_152763:c.T2488A:p.W830R WDR47 chr1 109525380 109525381 T C exonic NM_001142550:c.A2140G:p.M714V CELSR2 chr1 109815841 109815842 C T exonic NM_001408:c.C8393T:p.A2798V CELSR2 chr1 109815883 109815884 G A exonic NM_001408:c.G8435A:p.R2812Q MYBPHL chr1 109838925 109838926 G A exonic NM_001010985:c.C797T:p.P266L SORT1 chr1 109870190 109870191 G C exonic NM_001205228:c.C993G:p.I331M PSMA5 chr1 109953724 109953725 C A exonic NM_001199772:c.G295T:p.D99Y Case ID (average coverage for tumorous tissue [T] sample) "Non-reference read number/total (non-reference and reference) read number in T sample; non-reference read number/total read number in N sample" for each genetic aberration has been shown. A1 (143.3 ) A2 (106.6 ) 12/31; 0/24 A3 (147.4 ) 37/251 ;0/247 31/174 ;0/166 B1 (153.9 ) 25/192 ;0/141 31/230 ;1/164 A4 (136.7 ) 43/146 ;0/126 20/52; 1/61 51/197 ;1/173 26/123 ;0/116 A5 (142.4 ) 35/108 ;0/105 B2 (102.4 ) 30/67; 0/59 7/52;0/ 78 A6 (131.0 ) B3 (114.4 ) 18/108 ;1/150 B4 (125.8 ) 36/92; 1/82 63/162 ;2/151 27/64; 0/55 A7 (102.1 ) 21/130 ;1/111 A8 (137.7 ) 25/70; 0/46 8/60;0/ 42 A9 (123.9 ) A10 (121.7 ) 24/96; 0/64 16/83; 0/81 A11 (112.6 ) 9/59;0/ 53 A12 (100.5 ) 18/57; 0/44 A13 (118.0 ) 24/73; 0/68 91/381 ;0/372 A14 (110.4 ) 20/61; 0/56 4/31;0/ 25 28/99; 0/124 A15 (101.9 ) 21/85; 0/124 A16 (113.4 ) A17 (128.7 ) 11/46; 0/54 A18 (110.0 ) 18/64; 0/69 A19 (96.2 ) 39/122 ;1/134 A20 (120.7 ) 34/143 ;1/104 12/88; 0/92 45/232 ;1/233 A21 (126.6 ) 15/42; 0/37 33/106 ;0/120 28/106 ;0/107 A22 (101.8 ) 21/72; 1/63 47/148 ;0/150 B5 (114.8 ) 19/82; 0/73 13/113 ;0/122 2/15;0/ 21 11/103 ;0/99 B6 (119.0 ) 19/127 ;2/150 30/181 ;2/226 12/94; 1/127 8/49;0/ 55 A23 (107.2 ) 53/171 ;0/191 9/71;0/ 80 35/132 ;0/124 A24 (125.1 ) 4/18;0/ 16 A25 (115.3 ) A26 (133.9 ) 4/22;0/ 20 18/82; 0/104 34/145 ;0/152 A27 (138.7 ) 18/106 ;0/71 22/107 ;0/88 48/368 ;1/375 A28 (150.8 ) A29 (114.0 ) 9/85;1/ 87 A30 (123.9 ) 25/181 ;0/163 A31 (107.0 ) 8/57;0/ 86 35/153 ;0/181 4/30;0/ 44 A32 (129.8 ) A33 (110.8 ) 28/118 ;0/105 A34 (125.3 ) 56/204 ;1/210 22/69; 1/73 16/78; 0/53 97/333 ;2/335 B7 (115.9 ) 4/26;0/ 24 14/84; 0/86 8/63;0/ 58 16/116 ;1/121 10/92; 2/105 8/42;0/ 54 9/50;0/ 55 11/86; 0/97 15/129 ;0/159 9/62;1/ 81 8/65;0/ 83 9/80;0/ 73 14/122 ;1/117 4/28;0/ 45 A35 (110.7 ) 3/23;0/ 31 11/93; 0/93 18/78; 1/98 32/114 ;1/133 B8 (103.4 ) 8/48;0/ 74 67/210 ;0/266 56/211 ;2/257 A36 (125.4 ) A37 (123.6 ) 23/82; 0/101 A38 (119.2 ) 2/18;0/ 25 A39 (108.5 ) A40 (141.1 ) 18/60; 1/54 25/56; 1/96 17/47; 1/61 43/186 ;0/224 188/72 7;1/67 6 35/145 ;1/187 B9 (150.4 ) 30/124 ;0/110 16/98; 0/112 22/203 ;0/160 A41 (116.8 ) 14/67; 1/94 15/90; 0/75 A42 (147.4 ) 8/23;0/ 32 5/25;0/ 20 43/174 ;1/153 17/113 ;0/87 70/367 ;0/357 A43 (141.9 ) 25/55; 1/78 18/88; 0/101 101/26 3;1/28 4 111/26 7;2/25 7 A44 (124.3 ) 15/46; 0/74 10/54; 0/56 A45 (132.3 ) A46 (128.6 ) 16/84; 0/75 13/66; 0/73 21/89; 0/110 A47 (137.9 ) 61/169 ;2/214 B10 (139.2 ) 11/59; 0/53 58/231 ;2/257 A48 (133.6 ) A49 (131.1 ) A50 (96.0 ) A51 (127.4 ) A52 (126.5 ) 28/131 ;0/120 12/45; 0/51 A53 (99.2 ) B11 (98.4 ) 31/67; 0/108 A54 (144.2 ) A55 (144.9 ) A56 (147.8 ) 20/117 ;0/112 21/110 ;0/102 A57 (148.6 ) 5/46;0/ 23 2/18;0/ 16 13/115 ;0/105 53/208 ;0/159 53/224 ;2/229 76/314 ;1/287 A58 (132.6 ) 24/103 ;0/125 A59 (109.4 ) 11/23; 0/27 47/191 ;0/199 A60 (104.3 ) A61 (142.5 ) 42/191 ;0/183 20/143 ;0/147 A62 (100.2 ) 39/138 ;0/155 A63 (132.7 ) A64 (137.5 ) 8/63;0/ 54 A65 (148.4 ) 8/49;0/ 54 A66 (135.8 ) 5/44;1/ 51 52/176 ;0/200 A67 (136.3 ) 58/196 ;0/157 A68 (128.3 ) 21/77; 0/88 35/299 ;0/384 2/15;0/ 21 2/15;0/ 16 A69 (134.9 ) 17/137 ;1/164 A70 (100.1 ) A71 (145.2 ) 2/10;0/ 19 22/48; 0/49 A72 (140.2 ) 30/177 ;0/214 A73 (147.1 ) 2/15;0/ 20 A74 (156.5 ) 2/10;0/ 16 28/187 ;1/197 7/50;0/ 62 39/269 ;0/241 A75 (103.3 ) 14/102 ;0/116 A76 (91.2 ) 7/59;0/ 71 10/82; 0/94 3/22;0/ 40 A77 (94.7 ) A78 (106.9 ) 51/289 ;0/288 80/226 ;0/214 A79 (139.4 ) 58/251 ;0/198 49/222 ;1/207 A80 (102.4 ) 17/76; 0/70 17/52; 0/51 B12 (115.5 ) A81 (137.1 ) 2/18;0/ 24 B13 (105.5 ) 16/92; 0/92 14/106 ;0/105 A82 (109.0 ) 33/170 ;3/205 9/41;0/ 23 39/200 ;0/181 A83 (109.1 ) 26/53; 0/78 2/13;0/ 23 B14 (111.2 ) 30/103 ;0/81 32/108 ;0/113 A84 (128.1 ) 19/163 ;0/156 A85 (134.0 ) A86 (144.3 ) 13/33; 0/23 17/59; 1/55 21/61; 0/51 A87 (146.4 ) 13/56; 0/63 12/69; 0/77 37/250 ;0/241 Start position * End position *
EPS8L3 chr1 110293379 110293380 G T exonic NM_024526:c.C1582A:p.Q528K EPS8L3 chr1 110300144 110300145 A T exonic NM_024526:c.T927A:p.S309R SLC16A4 chr1 110924330 110924331 T A exonic NM_001201547:c.A121T:p.I41F LRIF1 chr1 111506272 111506273 G T exonic NM_018372:c.C38A:p.A13E CEPT1 chr1 111690346 111690347 A T exonic NM_001007794:c.A11T:p.H4L AP4B1(NM_006594:exon3: c.113+2t>c) chr1 114447224 114447225 A G sp DCLRE1B chr1 114453772 114453773 G C exonic NM_022836:c.G559C:p.E187Q HIPK1 chr1 114497373 114497374 C G exonic stopgain SNV NM_181358:c.C120G:p.Y40X OLFML3 chr1 114524012 114524013 A C exonic NM_020190:c.A843C:p.E281D TRIM33 chr1 114945472 114945473 A G exonic NM_015906:c.T2801C:p.I934T SYCP1;SYCP1 chr1 115420714 115420715 G C NM_003176:c.G802C:p.V268L TSHB chr1 115576010 115576011 C A exonic NM_000549:c.C28A:p.L10I MAB21L3 chr1 116670241 116670242 C T exonic stopgain SNV NM_152367:c.C637T:p.Q213X MAB21L3 chr1 116675983 116675984 T G exonic stoploss SNV NM_152367:c.T1087G:p.X363G PTGFRN chr1 117504146 117504147 A G exonic NM_020440:c.A1496G:p.N499S SPAG17 chr1 118539352 118539353 C A exonic NM_206996:c.G4790T:p.G1597V HMGCS2 chr1 120293434 120293435 C G exonic NM_001166107:c.G1391C:p.R464P HMGCS2 chr1 120306991 120306992 C T exonic stopgain SNV NM_001166107:c.G362A:p.W121X NOTCH2 chr1 120466318 120466319 C T exonic NM_024408:c.G4800A:p.M1600I POLR3GL chr1 145456679 145456680 A G exonic NM_032305:c.T614C:p.F205S ITGA10 chr1 145536039 145536040 C T exonic NM_003637:c.C2132T:p.A711V ITGA10 chr1 145537454 145537455 G A exonic NM_003637:c.G2465A:p.R822Q POLR3C chr1 145594141 145594142 T C exonic NM_006468:c.A1420G:p.M474V HIST2H2AB chr1 149859237 149859238 T C exonic NM_175065:c.A229G:p.T77A SV2A chr1 149878228 149878229 C T exonic NM_014849:c.G1858A:p.D620N SV2A chr1 149884961 149884962 T A exonic NM_014849:c.A431T:p.E144V MTMR11 chr1 149906391 149906392 C T exonic NM_181873:c.G280A:p.A94T VPS45 chr1 150049183 150049184 G T exonic NM_007259:c.G451T:p.D151Y TUFT1 chr1 151551260 151551261 C T exonic NM_001126337:c.C808T:p.L270F TCHH chr1 152080066 152080067 G A exonic NM_007113:c.C5626T:p.R1876W TCHH chr1 152080384 152080385 C T exonic NM_007113:c.G5308A:p.D1770N HRNR chr1 152193037 152193038 C T exonic NM_001009931:c.G1067A:p.G356E FLG chr1 152283655 152283656 G A exonic NM_002016:c.C3706T:p.R1236C FLG2 chr1 152327478 152327479 C A exonic NM_001014342:c.G2783T:p.G928V SPRR4 chr1 152944423 152944424 C A exonic NM_173080:c.C58A:p.Q20K NUP210L chr1 154110592 154110593 C T exonic NM_001159484:c.G839A:p.G280E NUP210L chr1 154110593 154110594 C T exonic NM_001159484:c.G838A:p.G280R UBAP2L chr1 154209550 154209551 T A exonic stopgain SNV NM_001127320:c.T642A:p.Y214X ADAR chr1 154562859 154562860 C T exonic NM_001025107:c.G1411A:p.G471S ZBTB7B chr1 154989051 154989052 A T exonic NM_015872:c.A1511T:p.Q504L ADAM15 chr1 155025166 155025167 G A exonic NM_003815:c.G100A:p.A34T SLC50A1 chr1 155108781 155108782 C A exonic NM_001122837:c.C47A:p.P16H SLC50A1 chr1 155110166 155110167 T C exonic NM_001122837:c.T248C:p.I83T FDPS chr1 155282168 155282169 G A exonic NM_001135822:c.G265A:p.G89S FDPS chr1 155290337 155290338 G A exonic NM_001242825:c.G685A:p.A229T RUSC1 chr1 155295360 155295361 C A exonic NM_001105205:c.C482A:p.S161Y GON4L chr1 155792159 155792160 G T exonic NM_001037533:c.C805A:p.L269M KIAA0907 chr1 155884060 155884061 C T exonic NM_014949:c.G1696A:p.A566T UBQLN4 chr1 156011954 156011955 A C exonic NM_020131:c.T1339G:p.F447V TMEM79 chr1 156255300 156255301 G T exonic NM_032323:c.G284T:p.R95L TMEM79 chr1 156261277 156261278 C G exonic stopgain SNV NM_032323:c.C1074G:p.Y358X GPATCH4 chr1 156565157 156565158 C G exonic NM_015590:c.G975C:p.R325S GPATCH4 chr1 156565308 156565309 C T exonic NM_015590:c.G824A:p.G275E PEAR1 chr1 156879574 156879575 C T exonic NM_001080471:c.C1444T:p.P482S ARHGEF11 chr1 156921434 156921435 C T exonic NM_014784:c.G1735A:p.D579N ARHGEF11(NM_198236:e xon3:c.33-2a>c,nm_014784:exon3:c.33-2a>c) chr1 156955966 156955967 T G sp FCRL5 chr1 157514177 157514178 T C exonic NM_001195388:c.A718G:p.S240G FCRL2 chr1 157737080 157737081 A G exonic NM_030764:c.T1102C:p.C368R SPTA1 chr1 158596769 158596770 C G exonic NM_003126:c.G5692C:p.E1898Q SPTA1(NM_003126:exon3 9:c.5432+2T>C) chr1 158605700 158605701 A G sp SPTA1 chr1 158627477 158627478 A T exonic NM_003126:c.T2594A:p.F865Y SPTA1 chr1 158653228 158653229 T A exonic NM_003126:c.A322T:p.M108L OR6K2 chr1 158669996 158669997 A C exonic NM_001005279:c.T446G:p.V149G OR6K3 chr1 158687621 158687622 G A exonic NM_001005327:c.C284T:p.T95I PYHIN1 chr1 158914787 158914788 C A exonic NM_152501:c.C1315A:p.P439T CCDC19 chr1 159846405 159846406 T C exonic NM_012337:c.A1292G:p.K431R IGSF9 chr1 159901251 159901252 A G exonic NM_001135050:c.T1504C:p.Y502H IGSF8 chr1 160061635 160061636 T G exonic NM_052868:c.A1819C:p.M607L DCAF8 chr1 160188747 160188748 A G exonic NM_015726:c.T1451C:p.L484P SLAMF6 chr1 160465993 160465994 G A exonic NM_001184714:c.C239T:p.P80L ARHGAP30 chr1 161021478 161021479 T A exonic NM_001025598:c.A1045T:p.S349C B4GALT3 chr1 161141664 161141665 G A exonic NM_001199873:c.C1123T:p.P375S ATF6 chr1 161928345 161928346 G C exonic NM_007348:c.G1915C:p.D639H OLFML2B chr1 161969988 161969989 C T exonic NM_015441:c.G863A:p.R288Q NOS1AP chr1 162270492 162270493 A G exonic NM_001164757:c.A326G:p.Y109C GPR161 chr1 168065936 168065937 G A exonic NM_153832:c.C908T:p.P303L SELL chr1 169673758 169673759 G A exonic NM_000655:c.C755T:p.T252I C1orf112 chr1 169806098 169806099 A T exonic NM_018186:c.A1571T:p.E524V C1orf112 chr1 169806104 169806105 A C exonic NM_018186:c.A1577C:p.E526A C1orf112 chr1 169811615 169811616 C A exonic NM_018186:c.C1784A:p.T595K GORAB chr1 170508550 170508551 C T exonic NM_001146039:c.C337T:p.H113Y C1orf129 chr1 170967376 170967377 T A exonic NM_001163629:c.T1558A:p.S520T METTL13 chr1 171753527 171753528 G A exonic NM_014955:c.G544A:p.V182M PIGC chr1 172411195 172411196 C G exonic NM_002642:c.G567C:p.L189F RC3H1 chr1 173931151 173931152 T C exonic NM_172071:c.A1913G:p.Y638C TNN chr1 175048530 175048531 G A exonic NM_022093:c.G472A:p.E158K TNR chr1 175304864 175304865 C G exonic NM_003285:c.G3613C:p.E1205Q SEC16B chr1 177929984 177929985 C T exonic NM_033127:c.G877A:p.V293I TOR3A chr1 179054833 179054834 A G exonic NM_022371:c.A445G:p.R149G TOR1AIP1 chr1 179870490 179870491 A C exonic NM_015602:c.A707C:p.K236T CEP350 chr1 180000514 180000515 G A exonic NM_014810:c.G3611A:p.R1204H CEP350 chr1 180047699 180047700 C T exonic NM_014810:c.C5870T:p.P1957L XPR1 chr1 180832855 180832856 C T exonic NM_001135669:c.C1319T:p.S440L SHCBP1L chr1 182908314 182908315 G T exonic NM_030933:c.C1072A:p.L358I LAMC2 chr1 183177137 183177138 T C exonic NM_005562:c.T202C:p.C68R LAMC2 chr1 183204836 183204837 G A exonic NM_005562:c.G2428A:p.G810S TRMT1L chr1 185093047 185093048 T C exonic NM_001202423:c.A1295G:p.E432G SWT1 chr1 185143736 185143737 G T exonic NM_001105518:c.G458T:p.S153I HMCN1 chr1 186158885 186158886 G A exonic NM_031935:c.G16784A:p.R5595Q HMCN1 chr1 186158898 186158899 A C exonic NM_031935:c.A16797C:p.E5599D TPR chr1 186321134 186321135 T G exonic NM_003292:c.A2442C:p.L814F PTGS2 chr1 186645830 186645831 C A exonic NM_000963:c.G738T:p.E246D PTGS2 chr1 186646935 186646936 C T exonic NM_000963:c.G484A:p.E162K PLA2G4A chr1 186901933 186901934 C T exonic stopgain SNV NM_024420:c.C598T:p.R200X FAM5C chr1 190129881 190129882 A T exonic NM_199051:c.T1100A:p.L367Q UCHL5 chr1 192998746 192998747 A G exonic NM_001199261:c.T287C:p.V96A KCNT2 chr1 196303076 196303077 A C exonic NM_198503:c.T1897G:p.L633V CFH chr1 196694261 196694262 G A exonic NM_000186:c.G1708A:p.E570K ASPM chr1 197115439 197115440 T A exonic NM_001206846:c.A128T:p.H43L CRB1 chr1 197396688 197396689 C T exonic NM_001193640:c.C1898T:p.T633M CRB1 chr1 197398694 197398695 C G exonic NM_001193640:c.C2457G:p.S819R DENND1B chr1 197586858 197586859 G C exonic NM_001195215:c.C703G:p.L235V ZNF281 chr1 200377806 200377807 T C exonic NM_012482:c.A1027G:p.K343E KIF14 chr1 200522702 200522703 C T exonic NM_014875:c.G4760A:p.S1587N KIF14 chr1 200534595 200534596 T A exonic NM_014875:c.A3863T:p.Q1288L C1orf106 chr1 200867568 200867569 T C exonic NM_001142569:c.T41C:p.I14T IGFN1 chr1 201181966 201181967 G A exonic NM_001164586:c.G7946A:p.R2649K IGFN1 chr1 201196063 201196064 C T exonic NM_001164586:c.C10841T:p.P3614L PKP1 chr1 201282480 201282481 G A exonic NM_000299:c.G494A:p.G165D LGR6 chr1 202163319 202163320 C T exonic NM_001017403:c.C203T:p.T68M LGR6 chr1 202266645 202266646 T G exonic NM_001017404:c.T310G:p.Y104D KDM5B chr1 202742253 202742254 T C exonic NM_006618:c.A568G:p.S190G MYOG chr1 203053787 203053788 G T exonic NM_002479:c.C540A:p.S180R ATP2B4 chr1 203667334 203667335 C T exonic NM_001001396:c.C244T:p.H82Y LAX1 chr1 203734709 203734710 C T exonic NM_017773:c.C17T:p.P6L REN chr1 204130428 204130429 T A exonic NM_000537:c.A364T:p.T122S PLEKHA6 chr1 204228852 204228853 G C exonic NM_014935:c.C540G:p.D180E PLEKHA6 chr1 204237346 204237347 G T exonic NM_014935:c.C196A:p.L66I PPP1R15B(NM_032833:ex on3:c.1921-2a>c) chr1 204375442 204375443 T G sp PIK3C2B chr1 204438529 204438530 G A exonic NM_002646:c.C401T:p.S134L NUAK2 chr1 205272999 205273000 G T exonic NM_030952:c.C1465A:p.P489T SLC26A9 chr1 205898021 205898022 C T exonic NM_052934:c.G886A:p.A296T DYRK3 chr1 206821256 206821257 A T exonic NM_003582:c.A714T:p.K238N FAIM3 chr1 207087115 207087116 T C exonic NM_001193338:c.A361G:p.N121D CR2 chr1 207643072 207643073 A G exonic NM_001006658:c.A851G:p.N284S CR2 chr1 207644111 207644112 A C exonic NM_001006658:c.A1253C:p.N418T CR2 chr1 207646940 207646941 C T exonic NM_001006658:c.C2030T:p.T677M NEK2 chr1 211843660 211843661 C A exonic stopgain SNV NM_001204182:c.G727T:p.E243X FAM71A chr1 212798376 212798377 T C exonic NM_153606:c.T158C:p.I53T FLVCR1 chr1 213061279 213061280 T C exonic NM_014053:c.T1244C:p.I415T ANGEL2 chr1 213186602 213186603 G A exonic NM_144567:c.C217T:p.H73Y ANGEL2 chr1 213186613 213186614 A C exonic NM_144567:c.T206G:p.F69C PROX1 chr1 214170344 214170345 G A exonic NM_002763:c.G467A:p.R156H CENPF chr1 214830497 214830498 T G exonic NM_016343:c.T8708G:p.L2903R USH2A chr1 215963497 215963498 T A exonic NM_206933:c.A10085T:p.E3362V USH2A chr1 216144015 216144016 G C exonic NM_206933:c.C6908G:p.S2303C ESRRG chr1 216680340 216680341 T G exonic NM_001243505:c.A564C:p.K188N DUSP10 chr1 221875819 221875820 G C exonic NM_144728:c.C357G:p.D119E MIA3 chr1 222818925 222818926 C T exonic NM_198551:c.C3508T:p.P1170S CAPN2 chr1 223931857 223931858 G A exonic NM_001146068:c.G130A:p.A44T CAPN2 chr1 223936757 223936758 C G exonic NM_001146068:c.C513G:p.D171E DEGS1 chr1 224377539 224377540 C T exonic NM_003676:c.C344T:p.P115L TMEM63A chr1 226034841 226034842 G A exonic stopgain SNV NM_014698:c.C2323T:p.Q775X TMEM63A chr1 226041426 226041427 C T exonic NM_014698:c.G1700A:p.G567D TMEM63A chr1 226055591 226055592 C A exonic NM_014698:c.G510T:p.L170F PARP1 chr1 226552727 226552728 C T exonic NM_001618:c.G2633A:p.R878Q ZNF678 chr1 227842445 227842446 G T exonic NM_178549:c.G660T:p.W220C ZNF678 chr1 227842960 227842961 G C exonic NM_178549:c.G1175C:p.S392T PRSS38(NM_183062:exon 2:c.311+1G>C) chr1 228003953 228003954 G C sp OBSCN chr1 228476428 228476429 G T exonic NM_001098623:c.G10179T:p.W3393C OBSCN chr1 228509712 228509713 C A exonic NM_001098623:c.C15171A:p.F5057L URB2 chr1 229771067 229771068 G T exonic NM_014777:c.G708T:p.Q236H AGT chr1 230846045 230846046 A G exonic NM_000029:c.T551C:p.L184P ARV1 chr1 231124102 231124103 A G exonic NM_022786:c.A212G:p.Y71C C1orf124 chr1 231488504 231488505 T G exonic NM_032018:c.T868G:p.S290A TSNAX chr1 231700343 231700344 T A exonic NM_005999:c.T566A:p.L189Q DISC1 chr1 231830058 231830059 C G exonic NM_001012957:c.C555G:p.N185K SIPA1L2 chr1 232551331 232551332 G A exonic NM_020808:c.C4670T:p.S1557F PCNXL2 chr1 233353814 233353815 A T exonic NM_014801:c.T2620A:p.C874S PCNXL2 chr1 233386538 233386539 T C exonic NM_014801:c.A2168G:p.K723R SLC35F3 chr1 234367170 234367171 C T exonic NM_173508:c.C292T:p.R98C TARBP1 chr1 234586238 234586239 T C exonic NM_005646:c.A1796G:p.K599R IRF2BP2 chr1 234743483 234743484 T C exonic NM_001077397:c.A1115G:p.K372R ARID4B chr1 235345944 235345945 G C exonic NM_031371:c.C2031G:p.N677K LYST chr1 235916533 235916534 T A exonic stopgain SNV NM_000081:c.A7270T:p.K2424X LYST chr1 235964229 235964230 C G exonic NM_000081:c.G3880C:p.E1294Q NID1 chr1 236212108 236212109 C T exonic NM_002508:c.G406A:p.E136K HEATR1 chr1 236737548 236737549 A T exonic NM_018072:c.T3412A:p.C1138S 29/93; 0/94 2/19;0/ 32 8/47;0/ 57 22/161 ;0/136 139/45 7;1/40 8 16/55; 0/60 20/71; 1/72 33/108 ;1/127 7/62;1/ 78 10/76; 1/88 22/192 ;0/156 26/93; 1/98 26/113 ;1/144 10/85; 0/118 4/34;0/ 56 36/95; 1/82 33/207 ;1/264 19/134 ;0/142 6/32;0/ 30 27/170 ;1/145 2/18;0/ 25 39/165 ;0/134 34/129 ;1/101 72/304 ;0/318 23/108 ;0/103 20/87; 0/89 51/112 ;0/125 46/96; 0/87 15/96; 0/94 11/57; 0/57 13/47; 0/63 25/88; 0/102 24/106 ;0/103 29/121 ;0/101 47/217 ;0/220 21/91; 0/74 11/65; 0/70 2/11;0/ 18 15/66; 0/58 11/42; 0/39 39/121 ;0/128 9/39;0/ 39 42/148 ;0/187 7/32;0/ 45 30/81; 0/84 17/103 ;0/156 21/55; 0/62 27/72; 0/78 36/113 ;0/125 6/38;0/ 63 26/157 ;0/156 14/106 ;0/92 32/139 ;0/126 25/90; 0/84 10/88; 1/96 12/45; 0/42 50/243 ;0/238 13/82; 0/87 28/112 ;1/91 20/77; 0/78 29/148 ;1/135 22/105 ;0/95 7/32;0/ 18 44/165 ;2/225 2/17;0/ 21 2/16;0/ 17 15/49; 0/50 21/77; 0/103 35/142 ;0/178 35/337 ;3/374 15/143 ;2/131 11/75; 0/94 10/77; 0/91 3/29;0/ 36 33/194 ;0/220 4/12;0/ 16 16/125 ;0/177 13/109 ;0/140 32/285 ;0/319 24/129 ;0/132 2/10;0/ 15 23/81; 0/79 50/130 ;0/114 16/98; 0/106 66/265 ;0/255 43/148 ;0/129 22/204 ;0/220 11/93; 0/82 24/121 ;0/150 14/57; 0/56 41/131 ;1/119 2/18;0/ 15 44/153 ;1/169 23/166 ;0/144 94/215 ;0/197 13/78; 0/96 2/16;0/ 19 14/89; 0/75 45/136 ;0/131 47/236 ;0/206 36/230 ;3/274 48/249 ;0/262 33/141 ;0/120 2/16;0/ 19 51/233 ;2/270 81/163 ;0/117 87/241 ;2/281 12/109 ;0/126 30/127 ;0/124 15/56; 0/54 15/53; 0/55 25/73; 0/58 122/39 7;4/43 4 25/82; 0/69 44/135 ;1/136 6/28;0/ 17 55/137 ;1/138 2/9;0/1 6 49/186 ;0/152 46/134 ;0/129 39/151 ;1/142 30/168 ;0/142 16/83; 1/84 51/236 ;0/170 51/236 ;0/170 87/164 ;0/171 159/51 8;2/47 7 40/177 ;0/211 18/83; 0/116 26/112 ;0/107 24/77; 0/96 48/223 ;1/200 136/36 6;0/39 1 32/86; 0/89 75/194 ;1/201 77/204 ;1/211 52/385 ;0/399 10/92; 0/96 68/270 ;0/313 10/67; 0/80 43/130 ;0/130 24/69; 0/58 12/94; 0/100 17/107 ;0/108 13/82; 0/100 15/80; 0/93 21/109 ;1/127 20/78; 0/68 46/178 ;1/196 34/161 ;1/177 24/94; 0/104 20/87; 0/102 29/170 ;0/168 10/55; 0/53 26/117 ;0/99 18/147 ;0/189 6/30;0/ 32 32/146 ;1/133 52/193 ;0/148 7/49;0/ 47 2/13;0/ 17 5/23;0/ 22 89/405 ;3/335 15/113 ;1/127 67/288 ;0/217 21/94; 0/84 23/85; 0/62 56/229 ;1/208 18/79; 0/86 37/243 ;0/206 48/151 ;0/118 33/116 ;0/107 31/135 ;1/110 63/290 ;0/245 129/46 2;2/47 2 8/62;0/ 58 17/61; 0/66 8/45;0/ 37
MTR chr1 236978957 236978958 A C exonic NM_000254:c.A664C:p.I222L RYR2 chr1 237754128 237754129 G A exonic NM_001035:c.G3997A:p.D1333N RYR2 chr1 237758940 237758941 T C exonic NM_001035:c.T4580C:p.L1527P RYR2 chr1 237777726 237777727 A C exonic NM_001035:c.A5299C:p.S1767R RYR2 chr1 237947439 237947440 A C exonic NM_001035:c.A12428C:p.K4143T RYR2 chr1 237957280 237957281 C T exonic NM_001035:c.C13897T:p.L4633F FMN2 chr1 240256492 240256493 C G exonic NM_020066:c.C1084G:p.P362A FMN2 chr1 240286600 240286601 G T exonic stopgain SNV NM_020066:c.G1738T:p.E580X FMN2 chr1 240371538 240371539 C T exonic NM_020066:c.C3427T:p.P1143S FMN2 chr1 240492441 240492442 G A exonic NM_020066:c.G4282A:p.A1428T ADSS chr1 244580989 244580990 C T exonic NM_001126:c.G1010A:p.R337K ADSS chr1 244587347 244587348 T C exonic NM_001126:c.A488G:p.K163R HNRNPU chr1 245025802 245025803 T A exonic NM_004501:c.A780T:p.E260D KIF26B chr1 245848985 245848986 G T exonic NM_018012:c.G2701T:p.G901C KIF26B chr1 245851064 245851065 G A exonic NM_018012:c.G4780A:p.G1594R KIF26B chr1 245862231 245862232 G A exonic NM_018012:c.G6071A:p.R2024H ZNF496 chr1 247492809 247492810 G T exonic NM_032752:c.C71A:p.P24Q OR2W5 chr1 247655038 247655039 G A exonic NM_001004698:c.G610A:p.G204S OR2G2 chr1 247751675 247751676 A C exonic NM_001001915:c.A15C:p.R5S OR1C1 chr1 247921559 247921560 C G exonic NM_012353:c.G149C:p.G50A OR2M3 chr1 248367106 248367107 G T exonic NM_001004689:c.G738T:p.L246F ZNF672 chr1 249142469 249142470 C T exonic NM_024836:c.C997T:p.H333Y PGBD2 chr1 249210948 249210949 G C exonic NM_170725:c.G166C:p.D56H DIP2C chr10 323380 323381 C A exonic NM_014974:c.G4555T:p.V1519L AKR1E2 chr10 4877951 4877952 A C exonic NM_001040177:c.A410C:p.E137A FBXO18 chr10 5948417 5948418 T G exonic NM_178150:c.T576G:p.I192M IL2RA chr10 6063449 6063450 G T exonic NM_000417:c.C574A:p.Q192K PRKCQ chr10 6540363 6540364 A G exonic NM_001242413:c.T536C:p.F179S ITIH2 chr10 7773865 7773866 C A exonic NM_002216:c.C1554A:p.F518L TAF3 chr10 8051258 8051259 G T exonic NM_031923:c.G2534T:p.R845L UPF2 chr10 11971893 11971894 T C exonic NM_015542:c.A3779G:p.N1260S CAMK1D chr10 12858316 12858317 C T exonic NM_020397:c.C823T:p.R275W FAM171A1 chr10 15262959 15262960 A T exonic NM_001010924:c.T854A:p.M285K C1QL3 chr10 16563051 16563052 G T exonic NM_001010908:c.C13A:p.L5M CUBN;CUBN chr10 16932369 16932370 G A stopgain SNV NM_001081:c.C8755T:p.R2919X CUBN chr10 16980978 16980979 A G exonic NM_001081:c.T5716C:p.Y1906H CUBN chr10 17083210 17083211 T C exonic NM_001081:c.A3838G:p.N1280D CUBN chr10 17110638 17110639 T A exonic NM_001081:c.A2756T:p.H919L CUBN;CUBN chr10 17164896 17164897 C A NM_001081:c.G490T:p.G164C CACNB2 chr10 18827168 18827169 G T exonic NM_000724:c.G1198T:p.D400Y COMMD3-BMI1 chr10 22615376 22615377 A C exonic NM_001204062:c.A428C:p.E143A PIP4K2A(NM_005028:exo n3:c.145-2a>t) chr10 22898647 22898648 T A sp ARMC3 chr10 23250843 23250844 T G exonic NM_173081:c.T569G:p.L190R ARMC3 chr10 23270595 23270596 C G exonic NM_173081:c.C1142G:p.A381G KIAA1217 chr10 24669849 24669850 C A exonic NM_001098501:c.C407A:p.P136Q KIAA1217 chr10 24790357 24790358 G A exonic NM_001098501:c.G1780A:p.V594M KIAA1217 chr10 24820818 24820819 C A exonic NM_001098501:c.C3038A:p.P1013H KIAA1217 chr10 24833943 24833944 C G exonic NM_001098501:c.C3344G:p.P1115R MYO3A chr10 26442804 26442805 A T exonic NM_017433:c.A2662T:p.N888Y MYO3A chr10 26457699 26457700 C G exonic NM_017433:c.C3171G:p.D1057E MYO3A chr10 26462821 26462822 A G exonic NM_017433:c.A3629G:p.E1210G ANKRD26 chr10 27294550 27294551 C T exonic NM_014915:c.G5101A:p.V1701I ANKRD26 chr10 27324058 27324059 T G exonic NM_014915:c.A3320C:p.Q1107P ANKRD26 chr10 27337838 27337839 T C exonic NM_014915:c.A1705G:p.T569A ACBD5;ACBD5 chr10 27512380 27512381 T C NM_001042473:c.A271G:p.I91V PTCHD3 chr10 27702889 27702890 G A exonic NM_001034842:c.C290T:p.P97L ARMC4 chr10 28224172 28224173 T G exonic NM_018076:c.A2261C:p.E754A SVIL chr10 29747511 29747512 C T exonic NM_003174:c.G5131A:p.E1711K SVIL chr10 29820202 29820203 G A exonic NM_003174:c.C842T:p.S281L LYZL2 chr10 30915857 30915858 C T exonic NM_183058:c.G125A:p.R42Q ZNF438 chr10 31137480 31137481 C T exonic NM_001143767:c.G1853A:p.G618D PARD3;PARD3 chr10 34626352 34626353 A T NM_001184790:c.T2239A:p.S747T BMS1 chr10 43292105 43292106 G T exonic stopgain SNV NM_014753:c.G1414T:p.E472X OR13A1 chr10 45799494 45799495 C T exonic NM_001004297:c.G376A:p.A126T WDFY4 chr10 50081607 50081608 G A exonic NM_020945:c.G6814A:p.G2272S FAM170B chr10 50340364 50340365 G A exonic NM_001164484:c.C145T:p.P49S C10orf71 chr10 50534535 50534536 G T exonic stopgain SNV NM_001135196:c.G3946T:p.E1316X PGBD3 chr10 50724696 50724697 A G exonic NM_170753:c.T464C:p.I155T CHAT chr10 50863217 50863218 G T exonic NM_001142929:c.G1358T:p.R453I CHAT chr10 50873014 50873015 C A exonic NM_001142929:c.C1816A:p.L606M BICC1 chr10 60560053 60560054 A G exonic NM_001080512:c.A1826G:p.E609G PHYHIPL chr10 61005259 61005260 A T exonic NM_001143774:c.A962T:p.E321V FAM13C chr10 61022294 61022295 C T exonic NM_198215:c.G1135A:p.A379T SLC16A9 chr10 61424007 61424008 A G exonic NM_194298:c.T413C:p.L138P SLC16A9 chr10 61432602 61432603 C A exonic NM_194298:c.G265T:p.V89L ARID5B chr10 63852363 63852364 G A exonic NM_001244638:c.G2413A:p.E805K JMJD1C chr10 64975130 64975131 G A exonic stopgain SNV NM_004241:c.C250T:p.Q84X HERC4 chr10 69716654 69716655 C G exonic NM_015601:c.G2005C:p.D669H DNA2 chr10 70196873 70196874 C T exonic NM_001080449:c.G1540A:p.A514T SLC25A16 chr10 70246952 70246953 T C exonic NM_152707:c.A790G:p.T264A STOX1 chr10 70644831 70644832 A G exonic NM_001130161:c.A1280G:p.H427R DDX50 chr10 70693975 70693976 G C exonic NM_024045:c.G1261C:p.D421H KIAA1279 chr10 70775629 70775630 A T exonic stopgain SNV NM_015634:c.A1324T:p.R442X TACR2 chr10 71168756 71168757 C T exonic NM_001057:c.G662A:p.G221D KIAA1274 chr10 72289069 72289070 G C exonic NM_014431:c.G271C:p.E91Q ASCC1 chr10 73921389 73921390 G C exonic NM_001198798:c.C532G:p.P178A OIT3 chr10 74658608 74658609 C A exonic NM_152635:c.C249A:p.H83Q P4HA1;P4HA1(NM_00114 2596:exon11:c.1248+1G>A ) chr10 74790027 74790028 C T NM_000917:c.G1249A:p.V417I USP54 chr10 75286478 75286479 G C exonic NM_152586:c.C2120G:p.S707W USP54 chr10 75301264 75301265 C G exonic NM_152586:c.G693C:p.E231D SYNPO2L chr10 75407436 75407437 T C exonic NM_024875:c.A1301G:p.N434S KIAA0913 chr10 75554357 75554358 G A exonic NM_001242487:c.G2854A:p.D952N NDST2 chr10 75567925 75567926 G T exonic NM_003635:c.C221A:p.P74H FAM213A chr10 81841908 81841909 T A exonic NM_025125:c.T200A:p.L67H ANXA11 chr10 81928933 81928934 G A exonic NM_001157:c.C352T:p.P118S DYDC2 chr10 82122237 82122238 C A exonic stopgain SNV NM_032372:c.C39A:p.C13X RGR chr10 86008684 86008685 C A exonic NM_001012720:c.C244A:p.P82T FAM190B chr10 86131105 86131106 C T exonic NM_018999:c.C298T:p.P100S GRID1 chr10 87484321 87484322 C G exonic NM_017551:c.G1645C:p.E549Q WAPAL chr10 88259872 88259873 G T exonic NM_015045:c.C1127A:p.T376N MMRN2 chr10 88702817 88702818 C G exonic NM_024756:c.G1723C:p.V575L ATAD1(NM_032810:exon5: c.382+2t>a) chr10 89550064 89550065 A T sp PTEN chr10 89653819 89653820 G T exonic stopgain SNV NM_000314:c.G118T:p.E40X PTEN chr10 89711892 89711893 C A exonic NM_000314:c.C511A:p.Q171K LIPN chr10 90522048 90522049 T G exonic NM_001102469:c.T213G:p.H71Q LIPM chr10 90568168 90568169 A T exonic NM_001128215:c.A262T:p.T88S IFIT3 chr10 91092380 91092381 T C exonic NM_001031683:c.T2C:p.M1T PCGF5 chr10 92982722 92982723 C T exonic NM_032373:c.C95T:p.T32M PCGF5 chr10 93021107 93021108 G A exonic NM_032373:c.G500A:p.C167Y BTAF1 chr10 93740306 93740307 A G exonic NM_003972:c.A1747G:p.I583V EXOC6 chr10 94773999 94774000 G T exonic NM_001013848:c.G2130T:p.Q710H LGI1 chr10 95556997 95556998 A C exonic NM_005097:c.A1112C:p.Q371P PLCE1 chr10 95848998 95848999 G C exonic NM_001165979:c.G148C:p.E50Q PLCE1 chr10 96006176 96006177 G A exonic NM_001165979:c.G1971A:p.M657I PLCE1 chr10 96058257 96058258 G T exonic NM_001165979:c.G4366T:p.A1456S PLCE1 chr10 96058291 96058292 A C exonic NM_001165979:c.A4400C:p.K1467T PLCE1 chr10 96058292 96058293 A T exonic NM_001165979:c.A4401T:p.K1467N NOC3L chr10 96121480 96121481 A G exonic NM_022451:c.T158C:p.V53A TBC1D12 chr10 96291132 96291133 A C exonic NM_015188:c.A2175C:p.K725N DNTT chr10 98079066 98079067 C A exonic NM_001017520:c.C427A:p.P143T LCOR chr10 98714959 98714960 T C exonic NM_001170765:c.T583C:p.W195R MMS19 chr10 99223757 99223758 G C exonic NM_022362:c.C1769G:p.A590G ZFYVE27 chr10 99498319 99498320 C T exonic NM_001002261:c.C86T:p.P29L PYROXD2 chr10 100150804 100150805 G C exonic NM_032709:c.C1097G:p.S366C HPS1 chr10 100182216 100182217 G A exonic NM_000195:c.C1652T:p.T551I ABCC2 chr10 101567953 101567954 A G exonic NM_000392:c.A1783G:p.M595V ABCC2(NM_000392:exon2 4:c.3414+1G>A) chr10 101594292 101594293 G A sp DNMBP chr10 101716628 101716629 A G exonic NM_015221:c.T602C:p.L201P SEMA4G;SEMA4G chr10 102738773 102738774 A T NM_001203244:c.A812T:p.K271M SFXN3 chr10 102799285 102799286 C T exonic stopgain SNV NM_030971:c.C922T:p.Q308X PPRC1 chr10 103908636 103908637 C T exonic stopgain SNV NM_015062:c.C4681T:p.Q1561X SUFU;SUFU chr10 104264090 104264091 G T NM_001178133:c.G182T:p.W61L TAF5 chr10 105147769 105147770 G A exonic NM_006951:c.G2193A:p.M731I CALHM3 chr10 105233266 105233267 G T exonic NM_001129742:c.C738A:p.F246L CCDC147 chr10 106128191 106128192 G C exonic NM_001008723:c.G804C:p.E268D XPNPEP1 chr10 111633159 111633160 T G exonic NM_001167604:c.A1345C:p.T449P XPNPEP1 chr10 111637807 111637808 T G exonic NM_001167604:c.A1191C:p.K397N ADD3 chr10 111881967 111881968 G T exonic NM_001121:c.G1061T:p.G354V MXI1 chr10 112044637 112044638 A G exonic NM_001008541:c.A442G:p.I148V ADRA2A chr10 112838173 112838174 C A exonic stopgain SNV NM_000681:c.C420A:p.C140X NRAP(NM_198060:exon43 :c.5089-2a>t,nm_006175:exon42: c.4984-2a>t) chr10 115348839 115348840 T A sp NRAP chr10 115352029 115352030 G A exonic NM_006175:c.C4462T:p.R1488W C10orf81 chr10 115529572 115529573 C A exonic NM_001193435:c.C202A:p.L68I TRUB1 chr10 116698064 116698065 C T exonic NM_139169:c.C53T:p.T18I FAM204A chr10 120095898 120095899 A C exonic NM_001134672:c.T29G:p.L10R PRLHR chr10 120354422 120354423 C T exonic NM_004248:c.G334A:p.A112T C10orf46 chr10 120513945 120513946 C A exonic NM_153810:c.G329T:p.S110I EIF3A chr10 120802092 120802093 C A exonic NM_003750:c.G2939T:p.R980L EIF3A chr10 120817528 120817529 C T exonic NM_003750:c.G1916A:p.R639H SFXN4 chr10 120917387 120917388 T C exonic NM_213649:c.A466G:p.S156G BAG3 chr10 121431882 121431883 T G exonic NM_004281:c.T624G:p.I208M MCMBP chr10 121602040 121602041 G A exonic NM_024834:c.C1073T:p.A358V ATE1 chr10 123673352 123673353 T C exonic NM_001001976:c.A289G:p.M97V TACC2 chr10 123976287 123976288 G C exonic NM_006997:c.G1725C:p.Q575H DMBT1 chr10 124379776 124379777 C A exonic NM_004406:c.C2983A:p.L995M C10orf120 chr10 124457588 124457589 G T exonic NM_001010912:c.C668A:p.A223D CHST15 chr10 125804203 125804204 C G exonic NM_014863:c.G778C:p.G260R CHST15 chr10 125805389 125805390 G C exonic stopgain SNV NM_014863:c.C339G:p.Y113X OAT;OAT chr10 126086670 126086671 T C NM_001171814:c.A746G:p.D249G OAT chr10 126091602 126091603 T C exonic NM_001171814:c.A379G:p.I127V ADAM12 chr10 127731695 127731696 A G exonic NM_003474:c.T2026C:p.C676R ADAM12 chr10 127806613 127806614 G T exonic NM_003474:c.C605A:p.A202E MKI67 chr10 129904087 129904088 C T exonic NM_001145966:c.G4936A:p.V1646I MKI67 chr10 129905344 129905345 C G exonic NM_001145966:c.G3679C:p.D1227H BNIP3 chr10 133784439 133784440 A C exonic NM_004052:c.T317G:p.V106G JAKMIP3 chr10 133954080 133954081 G C exonic NM_001105521:c.G1471C:p.E491Q LRRC27 chr10 134158103 134158104 T C exonic NM_001143757:c.T503C:p.L168P KNDC1 chr10 134999497 134999498 C T exonic NM_152643:c.C646T:p.R216W VENTX chr10 135053209 135053210 C T exonic NM_014468:c.C272T:p.A91V NLRP6 chr11 284631 284632 C A exonic NM_138329:c.C2530A:p.Q844K IFITM5 chr11 298631 298632 C T exonic NM_001025295:c.G268A:p.A90T RNH1 chr11 498823 498824 C A exonic NM_203384:c.G724T:p.V242L EPS8L2 chr11 720218 720219 C T exonic NM_022772:c.C323T:p.S108L PNPLA2 chr11 821962 821963 T G exonic NM_020376:c.T426G:p.N142K AP2A2 chr11 959467 959468 A G exonic NM_001242837:c.A99G:p.I33M MUC2 chr11 1093429 1093430 C A exonic NM_002457:c.C5249A:p.T1750N 2/11;0/ 19 36/183 ;0/161 51/286 ;4/290 18/81; 0/61 27/110 ;1/110 30/144 ;0/139 46/172 ;0/141 39/234 ;0/171 79/329 ;0/299 24/92; 0/62 45/222 ;0/180 24/109 ;0/89 46/164 ;1/145 21/96; 1/109 22/52; 0/65 30/254 ;1/214 27/90; 0/95 87/336 ;1/385 43/152 ;0/140 34/173 ;0/243 52/66; 0/90 42/54; 1/105 28/115 ;0/106 2/11;0/ 17 18/118 ;2/107 10/72; 1/106 2/12;0/ 25 2/15;0/ 32 68/150 ;0/175 56/103 ;0/107 3/11;0/ 19 23/119 ;2/126 140/29 4;1/25 1 39/91; 0/88 17/85; 1/119 5/22;0/ 31 49/361 ;1/389 10/41; 1/52 23/84; 0/79 89/231 ;0/223 2/18;0/ 19 70/258 ;0/294 42/87; 0/64 52/180 ;0/168 18/63; 0/53 35/122 ;0/117 76/223 ;1/238 60/191 ;0/186 13/63; 0/101 28/115 ;0/116 48/158 ;0/181 3/24;0/ 31 59/175 ;1/137 18/89; 0/84 24/84; 0/84 16/130 ;0/95 58/141 ;0/138 32/105 ;0/92 19/73; 0/87 12/73; 0/81 34/159 ;2/143 19/146 ;0/124 47/241 ;0/265 21/136 ;0/142 30/112 ;1/111 49/201 ;0/246 11/65; 0/97 57/286 ;0/278 2/11;0/ 24 26/157 ;0/143 2/16;0/ 21 8/52;1/ 58 11/81; 0/105 49/353 ;0/392 19/178 ;0/195 15/114 ;0/127 5/44;0/ 48 4/24;0/ 31 78/288 ;0/275 86/272 ;0/313 2/11;0/ 17 17/87; 0/148 20/88; 2/146 35/216 ;0/257 5/36;0/ 34 47/154 ;0/138 4/35;0/ 36 26/115 ;1/107 11/52; 0/36 14/73; 0/80 24/61; 0/53 20/50; 0/42 11/33; 0/36 29/87; 1/118 26/112 ;1/89 26/156 ;0/151 17/130 ;0/121 14/83; 0/99 2/15;0/ 18 17/87; 0/86 40/172 ;1/172 9/39;0/ 46 14/49; 0/88 2/10;0/ 18 61/310 ;0/293 59/157 ;1/182 20/101 ;0/117 20/76; 0/72 11/75; 1/65 17/106 ;0/126 16/73; 0/63 19/95; 0/95 2/16;0/ 24 44/211 ;0/198 39/184 ;0/210 4/38;0/ 35 93/260 ;1/247 75/245 ;2/233 49/207 ;0/226 28/94; 0/131 26/110 ;0/124 19/183 ;1/172 27/111; 0/111 29/165 ;1/163 62/218 ;0/173 24/133 ;0/127 10/22; 0/26 41/123 ;1/147 32/98; 0/90 49/196 ;0/165 12/53; 1/73 19/73; 0/68 11/40; 0/33 17/120 ;0/81 38/195 ;1/203 15/86; 0/112 51/200 ;0/221 15/64; 0/54 28/78; 0/76 7/58;0/ 91 18/148 ;0/253 17/114 ;0/141 18/101 ;0/105 111/40 6;1/44 0 21/62; 0/65 37/157 ;1/173 17/59; 0/49 25/173 ;0/160 33/112 ;1/132 86/282 ;1/250 26/131 ;0/133 16/68; 0/73 10/51; 0/55 18/99; 0/148 13/51; 0/60 12/108 ;1/123 116/36 9;0/33 0 38/127 ;1/124 2/12;0/ 16 24/101 ;0/83 18/80; 0/78 56/230 ;0/206 5/21;0/ 27 11/89; 0/94 24/102 ;0/80 38/176 ;1/214 31/233 ;1/193 15/123 ;0/131 23/90; 0/103 4/19;0/ 22 31/134 ;0/126 2/14;0/ 25 17/67; 0/60 46/169 ;0/147 29/108 ;0/119 55/192 ;0/190