China Academic Journal Electronic Publishing House. All rights reserved.

Μέγεθος: px

Εμφάνιση ξεκινά από τη σελίδα:

Ἀντιόπη ΣoφпїЅα Ρέντης
7 χρόνια πριν
Προβολές:

1 (610041) ; 2. (), 96, 3 1 ( ) ( ),,2,2 ;,2,2, 8,( ITT), 12186% (9 /70), 12186% (9 /70),48158% (34 /70) ; 4117% (1 /24) 4117% (1 /24) 45183% (11 /24) ; ( ), 14175% (9 /61), 14175% (9 /61),55173% (34 /61) ; 5100% (1 /20) 5100% (1 /20) 55100% (11 /20), ( > 0105), ITT,18157% (13 /70), 81143% (57 /70), 20185% (5 /24) 75100% (18 /24) ;, 21131% (13 /61),93144% (57 /61), 25100% (5 /20) 85100% (17 /20), ( > 0105),, ; ; ; R 05; R A (2005) Shekag Capule i the Trea tm e t of Chro ic Glom eruloephr iti ( Q iy i liagxu Sy2 drom e) : A D ouble Blid, Radom ized Co trolled Tr ia l HOU L i 1, FU ig 1, SHA hao 2 hu i 13, HON G Hu i 1, Q IU Ho g2yu 1, Q IN W e i 1, TANG W e2fu 2, FAN J u2m ig 1, HAN G Rui2m ig 2, L I Tig2 qia D iviio of N ephrology, W et Chia Hopital of S ichua U iverity, Chegdu , Chia; 2. N atioal Ceter for D rug Cliical Trail ( TCM ), W et Chia Hopital, S ichua U iverity, Chegdu , Chia Abtract Objective To ae the effective ad afety of Shekag cap ule i the treatmet of chroic glomeruloe2 phriti (Q iyiliagxu Sydrome). M ethod A double blid, double dummy ad radomized cotrolled method wa adopted. A total of 96 patiet were radomized to the treatmet group ( Shekag capule, 2 cap ule, twice a day) ad the cotrol group (Sheyakag capule, 2 capule, twice a day). The therapeutic coure for both group wa 2 moth. Reult A ll the reult were aalyzed o the bai of itetio2to2treat( ITT) ad per2protocol2populatio ( ). For effect of chroic glomeruloephriti i the treatmet group, the cliical cotrol rate were 12186% (9 /70) with ITT aalyi ad 14175% (9 /61) with aalyi; the good imp rovemet rate were 12186% (9 /70) with ITT aalyi ad 14175% (9 /61) with aalyi; the total effective rate were 48158% (34 /70) ad 55173% (34 /61). I the cotrol group, the cliical cotrol ratewere 4117% (1 /24) with ITT aalyi ad 5100% (1 /20) with aalyi repectively; the good imp rovemet rate were 4117% (1 /24) with ITT aalyi ad 5100% (1 /20) with aalyi repectively; the total effective ratewere 45183% (11 /24) with ITT aalyi ad 55100% (11 /20) with aalyi. There wa o tatitical differece betwee the two group ( > 0105). For Q iyiliagxu ydrome improvemet, i the treatmet group, the cliical cotrol rate ad good imp rovemet rate were 18157% (13 /70) with ITT aaly2 i ad 21131% (13 /61) with aalyi repectively; the total effective rate were 81143% (57 /70) with ITT aalyi ad 93144% (57 /61) with aalyi repectively; I the cotrol group, the cliical cotrol rate ad good improvemet rate were 20184% (5 /24) with ITT aalyi ad 25100% (5 /20) with aalyi repectively; the total effective rate were 75100% (18 /24) with ITT aalyi ad 85100% (17 /20) with aalyi repectively. The reult howed o tatitical differece be2 twee the two group ( >0105). No advere effect were foud. Cocluio No tatitical differece wa detected betwee : : :,, 3 (Correpodece author) Chia Academic Joural Electroic ublihig Houe. All right reerved.

2 676 Chiee J Evidece2Baed Medicie, 2005, Vol15 (9) Shegkag cap ule ad Sheya cap ule group. No obviou toxic advere effect were foud. Key word Shekag cap ule; Chroic glomeruloephriti; Q iyiliagxu ydrome; Double blid radom ized cotrolled trial,,,,,,,, ( : 2002L0167), ,, [ 1 ] [ 2 ] 11111, ; ; ( Scr) 265 mol/l; ; 140 /90 mmhg h> 3 g; ; ; SAS ROCLAN,, ( ),,,,,,, :,,, 113 ( ) : 72,: ,2, 1 ( ) : 24,,,z ,: ,2, 1 8, :, ;:, (BUN) Scr,24 h [ 1 ], : - ( % ) = 100% : :, 95% :, 70% :, 30% : Chia Academic Joural Electroic ublihig Houe. All right reerved.

3 ,, < 30% : :, 24h ; (RBC) ; : 2 +, 24 h 40% ; RBC 3 /H 2 + ; ( 15% ) : 1 +, 24 h < 40% ; RBC< 3 / H 1 + ; : () ( ) 2 1, :,,, 1 :,, ; 2 :,,, ; 3 :,,, ; 4 :, 115, ( 8 ) 11, ( 4 ) 1 116,,, Fiher W ilcoxocmh ;, t W ilc2 oxo,, t W ilcoxo, SSS 10. 0,, Fiher 117, 2 211, 96,72, 24 2 ( ),13 81,61, 20, F ig Flow d iagram of ubject progre through the tr ia l 1,,, ,, Chia Academic Joural Electroic ublihig Houe. All right reerved.

4 678 Chiee J Evidece2Baed Medicie, 2005, Vol15 (9) Item 1( ITT) Table 1 Com par io of characteritic of two group ( ITT) Trial group Cotrol group value Sex (M /F), (Cae) 25 /45 9 /15 2 = Mea age ( x, year) = Severity (m ild /moderate / evere), (Cae) 21 /19 /30 5 /11 /8 = Coure ( ), ( h) 41 /19 /6 /4 11 /11 /0 /2 2 = Accumulated poit of ymp tom = U rie p rotei (1 + /2 + /3 + /4 + ), ( g) 14 /19 /23 /7 4 /9 /5 /2 = U rie red blood cell (1 + /2 + /3 + /4 + ) 21 /6 /3 /4 7 /2 /0 /1 = U rie p rotei of 24 hour ( g/24h) BUN abormal (mmol/l) Creatiie abormal ( mol/l) = ( ) 6 ( ) = ( ) 9 ( ) t = Cocom itat medicie ( Ye/No) 2 /68 0 /24 2 = [ ( %) ] Table 2 Com par io of effect o chro ic glom eruloephr iti [ ( %) ] Method Cliical cotrol Good imp rovemet Imp rovemet No improvemet ITT T 70 9 (12. 86) 9 (12. 86) 16 (22. 86% ) 36 (51. 43) C 24 1 (4. 17) 1 (4. 17) 9 (37. 5% ) 13 (54. 17) T 61 9 (14. 75) 9 (14. 75) 16 (26. 23% ) 27 (44. 26) C 20 1 (5. 00) 1 (5. 00) 9 (45. 00% ) 9 (45. 00) T: ( Trial group) ; C: (Cotrol group), [ ( %) ] Table 2 Com par io of effect o Q iy i liagxu ydrom e [ ( %) ] Method Cliical cotrol Good imp rovemet Imp rovemet No improvemet ITT T 70 2 (2. 86) 11 (15. 71) 44 (62. 86% ) 13 (18. 57% ) C 24 1 (4. 17) 4 (16. 67) 13 (54. 17% ) 6 (25. 00% ) T 61 2 (3. 28) 11 (18. 03) 44 (72. 13% ) 4 (6. 56% ) C 20 1 (5. 00) 4 (20. 00) 12 (60. 00% ) 3 (15. 00% ) h ( g) Table 4 Com par io of chage o 24 h ur ie prote i of two group ( g) D ifferece T < C Table 5 Com pario of chage o urie prote i of two group Cotet of urie p rotei T ( = 58) Before treatmet After treatmet C ( = 17) Before treatmet After treatmet D ifferece < t Chia Academic Joural Electroic ublihig Houe. All right reerved.

5 Table 6 Com pario of um ber of aborma l ur ie RBC of two group Cotet of urie p rotei 10 /H T ( = 28) Before treatmet After treatmet C ( = 9) Before treatmet After treatmet D ifferece Idex BUN (mmol/l) Scr ( mol/l) 7 Table 7 Com pario of effect o aborma l rea l fuctio of two group Before treatmet After treatmet D ifferece T C T C () Table 8 Com pario of effect o ym ptom tota l va lue of two group Group Before treatmet After treatmet T <0. 01 C < () Table 9 Compario of effect o differece of ymptom value betwee two group Symptom ale or yellow face Breath horte ad debility Fever of had & foot Back pai Edema Dry mouth ad throat Swellig ad pai of throat Total value 3 Group Differece T C T C T C T C T C T C T C T C ( ACE I) (ARB) [ 3 ],,,,,,,,,,,,,,,,,,,, ( ),,, : ( ITT/ ) 12186% / 14175%, 12186% /14175%, 48158% /55173% ;( ITT/ ) 18157% /21131%, 81143% /93144% ;, 0101 ( > 0105), Chia Academic Joural Electroic ublihig Houe. All right reerved.

6 680 Chiee J Evidece2Baed Medicie, 2005, Vol15 (9), , ( = 01045),, ( = 0102) ; ( = 0106), ( = 01706),, ( = ),,,,,,,,,,, 1 Chiee p ricip le of cliical reearch for ew traditioal herb i trea2 tig chroic glomeruloephriti. heg XY, chief editor. Chiee pricip le of cliical reearch for ew traditioal herb [M ], 1t iue, Beijig. Chiee medicie ciece ad techology publihig houe, May p : [M ]. 1. :, p hag YK. Chroic glomeruloephriti[m ]. Ye RG, Chief editor. IteralMedicie. houe, p Fifth editio. Beijig: eopleπ medical publihig. [M ]. :. 5. :, p W ilmerwa, Rovi BH, Hebert CJ, Rao SV, Kumor K, Hebert LA. Maagemet of glomerular proteiuria: a commetary [ J ]. N ephrol, 2003; 14 (12) : ( : ) ( : hilw iffe) J Am Soc New, 2006,,,, (CA ) ( IdexMedicu) MEDL INE ubmed,, 16, 80,,, : 28, 257, 10100, ( ), : 305 ; : , 1995,,, /: ; E - mail: editor@ adrol1c;: www1adrol1c Chia Academic Joural Electroic ublihig Houe. All right reerved.

Σχετικά έγγραφα

M in ing the Com pa tib ility Law of M ultid im en siona l M ed ic ines Ba sed on D ependence M ode Sets

M in ing the Com pa tib ility Law of M ultid im en siona l M ed ic ines Ba sed on D ependence M ode Sets 39 4 ( Vol. 39 No. 4 2007 7 JOURNAL OF SICHUAN UN IVERSITY ( ENGINEER ING SC IENCE ED ITION July 2007 : 100923087 (2007 0420134205 1, 1, 2, 1, 1, 3 (1., 610065; 2., 610075; 3., 150000 :, MM2 DE (MultidimesioalMedicie