Kubota'et'al.'Cell'Reports,''Supplemental'data,'related'to'Figure'2' ' ' ChIP%seq)analysis)of)the)binding)of)PCNA)in)the)presence)or)absence)of)Elg1)

Transcript

1 Kubota'et'al.'Cell'Reports,''Supplemental'data,'related'to'Figure'2' ' ' ChIP%seq)analysis)of)the)binding)of)PCNA)in)the)presence)or)absence)of)Elg1) across)the)yeast)genome) ' PCNA'ChIP>seq'analysis'was'performed'as'shown'in'main'Figure'2.'Note'that' some'peaks'reflect'unannotated'replication'origin'sites,'for'example'the'peak'at' ~0.133'Mbp'on'ChrIV'corresponds'to'unannotated'ARS407.'Many'such'non> annotated'sites'with'pcna'peaks'correspond'to' likely 'or' dubious 'origins'listed' in'the'oridb'database.''one'exception'was'identified;'~0.820'mbp'on'chrvii' shows'a'small'pcna'peak'that'does'not'correspond'to'any'previously'noted' origin'site.''this'peak'could'potentially'represent'a'previously'unnoted'origin.) '

2 chri ARS102.5 ARS103 ARS104 ARS105 ARS106 ARS107 ARS107.5ARS108 CEN_chr1 ARS109 ARS110 ARS111ARS112 ARS113 YAL068W-AYAL066W YAL064W BDH2 ECM1 GPB2 FLC2 YAL047W-AERV46 CDC19 FUN12POP5SNC1 SAW1 FUN30 TPD3CYS3SPO7 TRN1 EFB1 NUP60SEN34 ADE1 SUP56 YAR028W PRM9 YAT1 FLO1 YAR064W YAR068WIMD1 YAL067W-A YAL069WYAL064W-B GDH3 BDH1 CNE1 PEX22 OAF1 YAL044W-ACDC24 YAL037W YAL031W-A MTW1 FRT2 YAL019W-A PSK1 DEP1 SWC3 FUN14 YAL004W VPS8 SWD1tA(UGC)A YAR019W-A YAR029W UIP3 MST28SWH1 YAR053W YAR066W PHO11 YAR075W 30M 60M 90M 0.120M 0.150M 0.180M 0.210M PAU8 YAL065CYAL063C-A YAL059C-A ACS1 GEM1 YAL042C-A AIM1 GCV3 YAL037C-A CYC3YAL034C-B PRP45 MYO4 DRS2 LTE1FUN26 ATS1YAL016C-B NTG1MDM10 SSA1 ERP1 BUD14 CDC15 YAR023C YAR030C YAR047C YAR069C SEO1TDA8 FLO9 YAL056C-A AIM2 YAL045C SPC72 PTA1 CLN3 YAL037C-B RBG1FUN19 GIP4YAL026C-A MAK16 PMT2 CCR4 YAL018C YAL016C-A SYN8 ERP2 TFC3 RFA1 KIN3 PAU7 ts(aga)ayar035c-a YAR060C YAR070C 30M 60M 90M 0.120M 0.150M 0.180M 0.210M

3 chrii ARS200 ARS201 ARS201.5 ARS202 ARS203 ARS206 ARS207 ARS207.1 ARS207.5ARS207.8 CEN_chr2 ARS208 ARS209 ARS210.5 YBL109W YBL107W-A SFT2 tf(gaa)bna4 YBL095W MRP21 BOI1 NUP170 YBL073W AST1 PRS4 KIP1 YEL1 SHP1 TOD6SEC17 RRT1YBL044WPRE7 MRPL16 HEK2 YBL029W LSM2 NCL1 APN2 ACH1 FMT1ALK2 HIR1 PDR3 UTP20 COQ1 UGA2 tt(agu)b GAL1 POA1 YBL113W-A tl(uaa)b1 YBL108W YBL100W-C ATP1BRN1 RPL32 AVT5 YBL081WYBL077WYBL068W-A KTI11 YBL065W YBL062W YBL059W PTC3 YBL053W MOH1PSY4 ECM13 YBL039W-BAPL3 SHE1RPL19B RRN10 RFT1 ti(aau)b FUS3 YBL008W-A SCT1 YBL006W-A ts(aga)b HTB2 RCR1 HHT1 YBR016W FUR4 SCO2 YBL113C YBL111C YBL107C YBL112CPAU9 SRO77 PKC1 SEA4 RTG3 30M 60M 90M 0.120M 0.150M YBL100C YBL094C SCS22 TEL1 YBL086C YBL083C PET112 ILS1 YBL071C-B YBL070C AAR2 SEF1 SKT5 PTH2 SAS3 EDE1 YBL039C-A FUI1 YBL036C ECM21 YBL096C ROX3 MAP2 RPL23A CDC27 ALG3 ATG8 SSA3 YBL071C RPS8AUBP13PRX1 CMC2 YBL055C PIN4 COR1 ERD2 URA7 POL12 STU M 0.210M 0.240M PET9 YBL028C PIM1 POP8 tg(gcc)b YBL012C SLA1 HTA2NTH2 GPI18 YBL029C-A RIB1 MCM2HAP3 PEP1 RRN6 YBL010C LDB7 ECM15 RER2 DSF2 FLR M IPP1YBR013C MNN2GAL7 HHF1 YBR012C GRX7 KAP104 GAL10 RKM3 CHS3 ETR1 YPK3 YBR027C OLA1CDS1 30M 60M 90M 0.120M 0.150M 0.180M 0.210M 0.240M 0.270M YBR032W RPL4A EDS1 ARS211 ARS212 ARS213 ARS214 ARS215 ARS215.5 ARS216 ARS217 ARS218 ARS219 CHS2 FIG1 FMP23 YBR051W tl(uaa)b2 tq(uug)b YBR064W HSP26 YBR074WECM33 td(guc)b MIS1 RFC5 PBY1VPS15 SIF2PHO88 YBR109W-A SUS1RAD16 MUD1 YBR126W-A CCZ1 CKS1YBR137W YBR141W-A ADH5 RTC2 ARA1 SPP381 CNS1 IFA38 CSH1 EXO5PEX32 YBR178W SWD3 YPC1 ATP3 FAT1 RPS11B YRO2 YBR056W-A YBR071W RDH54 ECM8 tr(ucu)btec1 AAC3YBR089W YBR096W MMS4 YMC2AIM3 ALG1 YBR113W TEF2YBR124W YBR126W-B YBR134W MEC1 YBR139W MAK5MRPS9 YSW1 APD1 RIB7 AMN1 CDC28 YSY6 UBS1 SEC66 ECM31DTR1 YBR184W 0.300M 0.330M HMT1 CSG2 CST26 TCM62 PDX3 SCO1 tv(uac)b QDR3 GIP M REB1 RFS1 PRP6 MUM2 TSC3 ZTA1YBR053C REG2 YBR056C-B UBP14 AKL1 ORC M 0.420M 0.450M 0.480M 0.510M 0.540M 0.570M YBR062C ECM2 TIP1YBR072C-A TAT1 SLM4 SEC18 UBC4YBR085C-A YBR090C POL30 PHO3 RXT2 YBR103C-A FES1 IML3 YSA1 LYS2 TKL2 YBR121C-A MRPL36 PTC4 YBR131C-A VMA2 OPY1 HSL7 IRA1 SUP45 TBS1 SLI15 TOS1 TYR1SSE2YBR174C SMY2 FZO1 SMP1MBA1 YBR063C TRM7NRG2 BAP2 ALG14YBR076C-ARPG1 SPT7 RPL19A IST2NHP6B TIM12 PHO5 YBR099C EXO84 VID24 CMD1CYC8 YBR116CCBP6 GRS1 TFC1 TPS1 ATG14 SHE3AGP2 YBR138C YBR141C YBR144C RPB5ICS2 ARL1 POP7NPL4UMP1 EHT1 YBR182C-A RPS6B ARS219.5 ARS220ARS221 ARS221.5 ARS222.5 ARS223 ARS224 ARS225 ARS227 ARS228.5 ARS229 YBR191W-A YBR190W GDT1 AIM4 BEM1 DER1 COS111 YBR206W YBR209W ERV15MET8 HPC2 YBR221W-A YBR224WSLX1 PBP2 YBR235W YBR242W RRT2 MRPS5 SRB6 POP4 SHM1 REI1 EFM2 DPB3MRPL27 YBR285W YBR287WBSD2 SUL1 MAL33 PAU24 PCH2 RPS9B RPL21A RIM2 YBR200W-A KTR4 MCM7KTR3 FTH1tE(UUC)BNGR1 SDS24ATG12YBR223W-A YBR225W YBR230W-A DAD3 PRP5 GPX2 SPO23 DUT1 MTC4 YBR259WTSC10 MRPL37 CHK1 PAF1 YBR284W APE3SNF5 VBA2 PCA1 MAL M 0.630M 0.660M 0.690M 0.720M 0.750M 0.780M 0.810M NTC20 YBR196C-A MSI1 YBR197C YBR201C-A DUR1,2 AME1 YBR220C PYC2PCS60 YBR226C ROT2SWC5 ARC40 YBR238CTHI2ALG7 ENP1 ARO4 YBR255C-A SHG1TAE1 YPT10 FMP21 HSM3 RIF1 YBR277CDUG2 APM3 YBR292C YBR296C-A YBR298C-ACOS2 YBR196C-B MED8 PGI1TAF5 LDH1tC(GCA)B YBP1 YBR219C PDB1 TDP1MCX1OM14 YBR232C ABD1 ERT1 YBR241CISW1 HIS7 TRS20 RIB5 RGD1 AIM5SLM6 BIT2 UBX7 PPS1 SAF1 SSH1 CTP1 PHO89 MAL31 YBR300C 0.600M 0.630M 0.660M 0.690M 0.720M 0.750M 0.780M 0.810M

4 chriii ARS300 ARS301 ARS302 ARS303 ARS320 ARS304ARS305 ARS306 ARS307 CEN_chr3 ARS308 ARS309 ARS310 ARS313 ARS314 ARS314.5 ARS315 ARS316 ARS317 ARS318 YCL065W VBA3 ADF1KAR4 LRE1SPS22YCL042W GID7 LSB5 RNQ1 KCC4 YCL076WHMLALPHA1 VAC17 PRD1 SPB1 YCL048W-A YCL046WGLK1 GFD2 STE50 FUS1YCL021W-A SUP53 BUD3 LDB16 YCL001W-B RER1MRPL32 SAT4 YCR016W MAK32 BPH1 FEN1 YCR038W-A YCR041W YCR047W-A YCR051W THR4YCR061W BUD31 RAD18 CPR4 YCR075W-A LEU2 VMA9 YCL001W-A PGS1 YCR001WtN(GUU)C PGK1 tm(cau)chtl1 SNT1 RBK1 MATALPHA1 YCR045W-A ARE1 RSC6 TAH1 SUP61 HCM1ATG15 SOL2 PTC6 SRB8 TRX3 CSM1 ABP1 KIN82 CDC50 tt(agu)c HMRA1 AHC2 YCR085W YCR087W FIG2 CDC39 YCR095W-A YCR097W-A 30M 60M 90M 0.120M 0.150M HMLALPHA2 GEX1 MRC1 FYV5 PEX34 APA1POF1 YCL041C MGR1 SRO9MXR2 HIS4 HBN1 AGP1 YCL022C NFS1YCL012C SGF29 STP22 YCL002C YCR006C YCP4 YCR007CADY2 YCR013C YCR015C CWH43 tk(cuu)c PET18 HSP30 YCR023C YCR024C-B YCR025C RHB1 YCL068CHA1 KRR1 MOS1 PBN1 YCL049CEMC1 PDI1ATG22GRX1 RRP7 BIK1 FRM2 YCL023C te(uuc)c DCC1 GBP2 YCL007C ILV6 CDC10 CIT2 SUF2RVS161 ADP1POL4 SUF16 YCR018C-A SRD1MAK31 YCR022C SLM5 PMP1 tq(uug)c NPP1 FEN M 0.210M 0.240M 0.270M SYP1 RRP43 BUD5 TAF2PER1 YCR049C IMG1 CTR86YIH1 SED4 RSA4 ERS1 PAT1 TUP1 YCR090C OCA4 GIT1 RIM1 RPS14A MATALPHA2 PHO87 YCR043C RRT12 BUD23 YCR050C PWP2 YCR064C IMG2 SSK22FUB1 YCR081C-A YCR087C-A MSH3 HMRA2 30M 60M 90M 0.120M 0.150M 0.180M 0.210M 0.240M 0.270M ARS319 PAU3 RDS1 YCR102W-A ADH7AAD M YCR099C YCR101C YCR108C YCR100C YCR102C 0.300M

5 chriv_1 ARS400 ARS403 ARS402.5 ARS404 ARS405 ARS405.5 ARS406 ARS409 ARS409.5 ARS410 YDL247W-A THI13 YDL241W AIM6 YDL233WPTP1 SHS1 DTD1 SHR3 UGA4 GLE1 RTN2TRM8 SEC31 NUS1 RPL35AYDL186WLYS20 YDL180W DLD2 PAR32 SFA1 YDL163W YDL159W-A CMR1 MSH5 RPC53 RPN5 CCT4 RGT2 RPL35B CDC53 YDL129W STF1 PCL2 SNA4YFH1 YDL114W-A CYK3 TRM3 MSS2 POL3 PMT1 SRP14 COS7 MPH2 YDL242WLRG1 PHO13OST4 SSB1 YDL221W YDL218W tg(gcc)d1 NHP2 YDL206WMRPL11 YDL196W SNF3 ARF1 RBS1VMA1 INH1 PCL9 YDL176W UGA3CDC36 ENT1STE7CLB3 YDL152W ATG9LDB17 BPL1 ARF2 SRF1 LYS21 RPP1B VCX1 YDL124W UBP1 YDL118W NUP84 YDL114W KIN28NSE4 BUG1 PMT5 NUR1 30M SOR2 AAD4 ADY3 YPD1 BRE4 HXT15 YDL240C-A GUD1GYP7 YDL228C HO 60M WHI4FMP45TIM22 GCS1 HBT1 CDC13RRI1 GDH2 90M 0.120M 0.150M 0.180M 0.210M 0.240M 0.270M NOP6 CWC2 ACK1 YDL199C ASF2 YDL185C-A PPH22 YDL183C AIR2 YDL172C UGX2FAP7 YDL162C YDL158C DHH1 SAS10 NOP14YDL144C RPO21 RDI1 RPL41B HNT1 YDL119C ATG20TMA17PHO2QRI1 GET3 RPN6 YDL094CRAM1 PRR2 YDL211C HEM3 MGT1 GGC1 UFD2 YDL187C RPL41A YDL177CDLD1 GLT1 NRP1 CDC9 YDL159C-B MHF2 YDL157C BUD30 COP1CRD1 SCM3 PPH21 CDC48 YDL121C IWR1 RRP42 YDL109C QRI7 DUN1 SNU23 OPI6 UBX3ASM4 30M 60M 90M 0.120M 0.150M 0.180M 0.210M 0.240M 0.270M ARS412 ARS413 ARS413.5 ARS414 ARS415 CEN_chr4 ARS416 ARS417 ARS417.5 ARS418 ARS419 NDE2 RPL13A YDL073W YDL068W UBC9TSR1YDL057W tk(uuu)d SIT4 MRP10 YDL034W DBP10 YDL025W-A ARP2 YDL086W SUB2 RPL31A BDF2 IDP1 YDL062W USO1MBP1 LHP1 NPC2 YDL041W YDL032W PRP9 YDL026W ta(agc)d GPD1 CDC7SLX5 APC11RPT2 ATP16RMD1RCR2 RAD57 GAL3 RPL4B RAD61 FAL1FYV1 YDR029W MRH1tQ(UUG)D1 ARO3 RSM10 HEM12 YDR053W td(guc)d YOS9YDR061W AIM7 RRG1 SNF11PPH3 GPM2 NOP1 ts(aga)d1 GRX6 PTC1MCD1 YDR003W-A YRB1 TRP1 SNQ2PSF1HED1 RPS11A SES1 MIC14 tl(uaa)d YDR034W-B KRS1 HEM13 VMS1 tr(ucu)d PST1 MAK21LCB2 RPS13 DOS2 TPS2 RAD M 0.330M 0.360M 0.390M YDL086C-A ASM4RPS16B THI3MDH3 RXT3 YET3 CBS1 PEX19 RPS29B PSA1YDL050C PBP4STP4 MTF2 SIR2 PRM7 YDL085C-A LUC7 RPP1A MRK1 VAM6 BRE1 YDL071C COX9 YDL063C RAD59 MCH1 SLC1 KNH1 FAD1 PRP11 NAT1 BSC1 PUS9 SLM3 YDL027C YDL023C GPR1 MPS1 YDL022C-A RTK1 DIA M RPN4 OSH M 0.480M YDL016C YDL012C YDL009C YDL007C-A NHP10 MAF1 YDR008C YDR015C KCS1 GCV1 CIS1NSI1 ERP3 TSC13 YDL011C tt(agu)d MED2 NTH1 SOK1 YDR010C DAD1 YDR018C tv(uac)d DAS2 VPS54 REG M 0.540M 0.570M PST2 YDR034C-A ENA5 ENA1 NRG1 BAP3 TPI1DBF4 YDR056C UBC5 OCA6 FMP16 IPT1 RAD28 LYS14 EHD3 ENA2 YDR042CRPC11 YDR048C DET1 CDC34TGL2 RTR2 DOA4 PAA1 ARS420 ARS421 ARS422 ARS422.5 ARS423 ARS425 ARS426.5 PET100 STN1 YDR089W DNF2GIS1 TVP15 ARP10 FOB1 YDR115W YDR118W-A COX26KIN1 SWF1 SED1 VPS41 RRP8 UBC13 YDR094W BMH2STE5 TRS85 IRC2 APC4 VBA4DPB4 YDR124WARO1 MTC5 HPR1 TAF12 NUM1 RPA14 HOM2 RGP1MTQ2 EKI1 GIR2 YDR157W SAC3 SSY1 CWC15TAF10 HSP42HMO1 YDR179W-A UBC1 CDC1 PLP1 SLY1 YDR193W REF2 YDR199W YDR203W MSC2 MSS4 ti(uau)dtcp1aha1 YDR161W TRM82 CDC37 SUP35 NGG1 SDH4YDR182W-A SCC2 CCT6YDR194W-A HST4 CBS2 SPC19 COQ4 EBS1YDR210W GCD6UPC2 ADR M 0.630M 0.660M SHU2PDC2 AFR1 tr(acg)d RRP1 RLI1 tq(uug)d2 MSH6 YDR102C TMS1 TFB5 TVP23 SSS1 SLU7 YDR090C YDR095C GRX3 ARX1SPO71 ti(aau)d TMN M 0.720M 0.750M 0.780M YDR114C ALT2TMA64 INO2 YDR131C SAC6 YDR133CVPS61 DOP1SAN1 SWI5 YDR149C ENT5 CPR1 SEC1 STB3 YDR109CPDS1 MRPL1 TRM1 ECM18 YDR132C FIN1 YCF1 RUB1 PEX7 MKC7 KGD2 CTH1 YDR154C NBP2 SEC5 YDR169C-A tq(uug)d3 SEC M 0.840M 0.870M ARG82 CSN9YDR183C-A UPS3 YDR187CNUP42CAB5 VPS64 UME6 YDR215C RSM24 SAS4YDR186C ATC1 RVB1 MSS116RKM2 RAV2 YDR209C RAD M 0.630M 0.660M 0.690M 0.720M 0.750M 0.780M 0.810M 0.840M 0.870M

6 chriv_2 ARS427.5ARS428ARS429 ARS429.5 ARS430 ARS430.5 ARS431 ARS431.5 ARS432 ARS432.5 YDR222WHTA1 SIR4 YDR230WLYS4 MRPL7 SUP2PEX5 TRS23 VHS1 BTT1 tg(gcc)d2pex10 CCC2 DON1 RNH202 ZIP1NSE3 HRQ1 SUR2 CFT1 PMT7 SSF2 YDR320W-B HIM1 MRPL35 YDR327W GPI8 SWR1 YDR336W YDR340W EMT1 YDR352W TRP4GGA1 ESC2 GTB1CRF1 ADK1 IVY1 HEM1 PRP42 BUD26 AMD2 YDR246W-A MNN10 PAM1 CHL4 YDR262W MSW1 GLO2 BSC2 RRP45 YDR290W INM2 MHR1 BFR2 GPI11 TFB1 OMS1 MCM21 ASP1 YCG1 UBX5 IRC3 MSN5 MRPS28 MRP1 SBE2 TRR1 SPC110 OPI M 0.930M 0.960M 0.990M 1.020M RAD9MFB1 HTB1 COX20 FMN1 YDR239CPRP28 YDR249C MET32 CTA1 HSP78 ts(aga)d2 SWM1 AKR1CIA1 YDR271C te(cuc)d PMP3 PHM6 SPR28 YDR220C PCF11 RTN1 SEC26 SNU56 YDR248C YDR250C RMD5 RKM4 YAP6 EXG2 DIN7 HEL2 YDR269C YDR274C YDR278C MTH1YDR282C GCN M 1.080M 1.110M 1.140M 1.170M YDR286CSRP101 DPL1 ATP5 RSC3 tv(cac)d HNT2 GIC2 PIB1IPK1 YFT2 DAD4PEP7 YSP2PEX3 YDR338C tx(xxx)dhxt7 YDR344C DPP1RTT103 SSD1 HDA2 PRO1 YDR306C CPR5SRB7 SUM1 RAD34 tf(gaa)d SWA2 TIM11 UTP4 SKP1YDR333C YDR341C FCF1 HXT6 HXT3 SVF1 YPS7 YDR354C-A CNL1 BCP1 PAL1ATP22YDR355C EAF1TFC M 0.930M 0.960M 0.990M 1.020M 1.050M 1.080M 1.110M 1.140M 1.170M tk(cuu)d1 ESC2 SEM1 ARS433 ARS434 ARS435 ARS437 ARS440 ARS441 ARS442 ARS446 KEI1 CTS2WIP1 ATP17ARO10 RPP2B MUS81SAC7 SHE9 SXM1 UTP5 URH1 DIT1PDR15 SIZ1 SYF1 RAD30 YPR1 FRQ1ARH1 RGA2YRA1 EFT2RVS167 SPT3 RPT3 YDR396W YDR401W HPT1 MRP20 YDR406W-A RRP17RPL12B ts(aga)d3 HKR1 SNX41 YDR431W YDR433WPPZ2 THI74 ARO80 RPN9 NPL3 GPI17GPI19 LRS4 YDR442W DOT1 YDR444WADA2 PPN1 TOM1 MFA1 STP1 PKH3 RPL27B SNF1DIG2VPS52 IZH1 RSM28 PLM2 SMT3 GRX2 GRH1 FPR2 YDR524W-C SNA2HLR1 ECM11 RPS18A NHX1 MRPL28 TFB3SPP41 SDC1 TRS31 SNM1 KRE2 SLD5MZM1 LCD1 YDR509W ACN9 SLF1EUG1 YDR521WAPI2 RBA50 CAB M CDC40 ESF1 YDR366C 1.230M 1.260M 1.290M 1.320M YDR370C VPS74 BCS1 YDR379C-A NKP1YDR387C SUF3 NCB2 RPB7 ADE8DFM1 ERD1 YDR417C YDR426C YDR371C-A XRS2 YDR374CLSM6 YDR381C-A ATO3 YDR391C UBA2 DIT2 TRS120STE14 YDR413C YDR415C SIP1 CAD M 1.380M 1.410M TIF35 PPM1 SSN2 YDR445CUTP6YDR455C TSA2 PFA5 YDR464C-A YDR467C UGO1 DYN2 BNA7 CYM1 APT2 tk(cuu)d2 RPS17B YHP1GUK1 YDR461C-A HEH2 RMT2 TLG1 PRP3 YDR476C JIP M PEX29 CWC21VPS60 PAC11 YDR491C PHO8VPS72 RIB3PKH1 VPS3 PUF6 SEC20 SAM2 SPG3 ITR1RPL37BLPP1 tl(caa)d PSP1 GMC1 YDR510C-A GIN M YDR514C URC2 YDR524C-B SPS1 YDR526CAPA2 GNP1 EMI1EMI2 YDR524C-A SPS2 AGE1 QCR7 KRE M 1.230M 1.260M 1.290M 1.320M 1.350M 1.380M 1.410M 1.440M 1.470M ARS447 STL1 PAD1 PAU10 FDC1 YRF M 1.530M KRE28 FIT1YDR537CYDR541C YDR544C HSP31 YDR535C IRC4YDR543C YDR545C-A 1.500M 1.530M

7 chrv ARS502 ARS503 ARS504 ARS507 ARS508 ARS510 CEN_chr5 ARS511 ARS511.5 ARS512 ARS513.5 ARS513.7ARS514 YEL075W-A RMD6 YEL077W-A YEL074W DLD3 DSF1 SIT1 HHY1HAT2YEL050W-A AFG1 IES6 HPA3 NPR2 PCM1 YEL053W-AVMA8PAU2YEL043W GDA1 UTR2 ts(aga)e HYP2 SPF1 YEL028W VMA3 RIP1 URA3EAF5EDC3UBC8 YEL010W YEL008W YEA6 GIM4 NOP16 YND1 PAC2 TIR1 PRE1 HEM14BIM1 GPA2 SRB4 th(gug)e1 YAT2 FIR1 YER038W-A EDC2 YEN1 SPO73 tq(uug)e1 TPA1 PET117 FCY21 THO1 RGI1 ARG5,6 YEF1UTR4MTC7 MCM3ECM10 IMT4 SNU13 GEA2 TIM9 GTT3VAC8 tr(ucu)e GLC3 MIT1YEA4 MNN1 FMP52 NUG1 te(uuc)e1 NTF2 PRP22FAA2 ISC1RPN3 PRO3 GCD11 CHZ1YER034W PHM8 GLN3 MXR1 YER046W-AISD11JHD1 PCL6 FCY22 RRT13 MOT2RNR1 YEL077C YEL076C YEL073C YEL076C-A YEL075C 30M 60M 90M 0.120M 0.150M 0.180M 0.210M 0.240M 0.270M YEL068CAVT2 CIN8SOM1 POL5 MAK10 tg(gcc)e YEL045C FRD1 RAD23 YEL032C-A UTR5 BUD16 YEL023CYEL018C-A YEL020CtQ(UUG)E2 NPP2YEL009C-A YEL008C-A WBP1 PMI40 TMA20 YER010C AFG3 SBH2 CHO1 MIG3 YPT31 ARB1HVG1 SAH1 MEI4 SAP1 RSM18PIC2GIP2FCY2 HMF1 HOR2YER066C-A ICL1YER068C-A HXT13 YEL067CCAN1 PRB1 YEL057CRPL12A RML2 TCA17 GLY1 CYC7 YEL034C-A ANP1YEL030C-AYEL025C YEL020C-B MMS21 PMP2 YEL014C tk(cuu)e1gcn4 VAB2 IRC22 YER006C-ASEC3 BUD25 SPC25 YER023C-A GAL83 SMB1 ZRG8 YER039C-A KRE29 ERG28 ACA1 CAJ1 YER053C-A HOM3 HIS1 RPL34A CEM1 VHR2 YER067C-A SUP19 30M 60M 90M 0.120M 0.150M 0.180M 0.210M 0.240M 0.270M ARS516 ARS517 ARS518 ARS519 ARS520 ARS521 ARS522 ARS523 VTC1 RPS24A YER076W-A YER079W YER084W-A SER3 AIM10 TRP2 te(uuc)e2 RAD51UBP9RPS8B RTT105 YER107W-A RPL23B YER121W RSP5VFA1RPS26B YER133W-A GDI1 YER138W-A COX15YER148W-A LSM5 tv(aac)e2 OXA1 YER158W-A RNR1ALD5 YOS1YER078W-A AIM9 YER084W ILV1 YER088W-B IES5 YER097W SHC1 UBC6SSA4 MAM1 LSM4 SCS2 YCK3 LCP5 SAK1 tv(aac)e1 GLC7 YER137W-A YER140W DDI1 SPT15 YER152W-A SPI1 COG3 CHD1 PAB1 BCK2 ADK2 RAD24ECM32 PDA1 FMP10 YER187W YER189W DNF1 RPH1 RAD3 YER175W-ABMH1 DMC1 PUG1YER188W YRF1-2 TDA2tA(UGC)E YER077C YER079C-AYER087C-A GET2 DOT6 PTC2MET6 TSC11 PUP3 AST2 GLE2 KAP123 TMN3SPR6 YER119C-A SHO1 DSE1 YER130C th(gug)e2 YER134C YER137C RTR1YER145C-A UBP5 YER147C-AUBP3 PET122YER156C YER158C tr(acg)e RAD4YER165C-A BRR2 GRX4 ti(aau)e2 ISC10 FAU1YER186C YER190C-A YER076C PTP3 ICP55 YER085C UTP7YER088C-A YER090C-A SBH1 YER091C-AIM11 PRS2 NUP157FLO8 SWI4 BOI2 SLX8AVT6 GLO3 NSA2 PMD1 tk(cuu)e2 YER135C ti(aau)e1 MAG1FTR1 SCC4 PEA2 YER152CBEM2 te(uuc)e3bur6 SPT2 YER163C CCA1 YER172C-A TMT1 YER181C SLO1 YER184CYER188C-A YER190C-B

8 chrvi ARS600.1 ARS600.2 ARS600.3 ARS600.4 ARS601 ARS602 ARS603 ARS603.1 ARS603.5ARS604ARS605 CEN_chr6 ARS606 ARS607 ARS608 ARS608.5 ARS609 ARS610 YFL067WCOS4SNZ3 AGP3 YFL052W RGD2 YFL041W-A YFL040W RPO41 YFL032W AGX1 BUD27 YFL015W-A SUF9 YFL013W-A YFL012W AUA1 YFL068W YFL063WDDI2 THI5 DAK2 SWP82 FMP32 FET5 TUB2 YFL034W HAC1 STE2 GAT1 SMX2 YFL012W-A HSP12HXT10 CDC4 SMC1 BLM10 SEC4 DEG1 NIC96 YFR006W FAR7 GCN20 YFR012W-A UBP6 SUP11 FAB1 ATG18PES4 PTR3 YFR034W-A YFR036W-ASAP155 YFR045WYMR31 IRC7 VTC2 LOC1 RPN11 YFR009W-A YFH7 YFR010W-A SUF20DCV1 IOC3 YFR020WROG3 ECO1MET10 CDC26 IRC5 KEG1 RMD8 RPN12 YFR057W YFL066C YFL064C YFL065C 30M AAD16 YFL054C SNO3 AAD6 YFL051C ALR2 60M 90M SEC53 YFL042C YPT1 RPL22BYFL031C-A CAF16BST1 FRS2 EMP47OTU1 ACT1 MOB2 RIM15 CAK1 GYP8 EPL1 YFL021C-A YFL019C PAU M 0.150M 0.180M 0.210M 0.240M 0.270M LPD1 MDJ1 IES1 MSH4 SPB4 SAD1 AIM13 tg(gcc)f2 GSY1YFR018C ta(agc)f LSB3CDC14 YFR032C-B SMC2 tk(cuu)f RRT5 PHO4 YFR039C IRC6CNN1 YFR052C-A PRE4 YFR054C YFL015C GNA1 WWM1 tn(guu)f YPI1 tf(gaa)f CMK1 YFR016C IGD1tS(GCU)F HIS2 ULI1SUP6 RPL2A RPL29 YFR035C QCR6 RSC8 ERJ5 DUG1 BNA6 RET2 HXK1 YFR056C 30M 60M 90M 0.120M 0.150M 0.180M 0.210M 0.240M 0.270M

9 chrvii_1 ARS702 YGL262W YPS5 VEL1 COS12 YGL258W-A YGL260W ADH4 ZRT1 HXK2 ZIP2 BRR6RTF1 KAP114 CSE1ADE5,7TAN1 VID30 VRG4 YGL218W CLG1 VAM7 YPT32 SIP2 FZF1 RMR1 PDE1 GUS1 TAD1DOC1 YGL235W SEC15 SHE10MTC3 FRA2 KIP3 YGL214W NCS6 MIG2 SPT16 PAU11 MNT2 ARS704 ARS706 ARS707 ARS710 ARS711 ARS714 POX1 ARO8 YIP4 tk(uuu)g1 tk(cuu)g1mds3 DSD1 IME4 GTS1 MPT5BUD13 ROK1 HUR1 SUT1 YGL159W GCN1 COX13 ATG1 YGL177W NUP49SUA5CUP2 tl(caa)g1 AIM14 RCK1 ARI1 AMS1 PEX14YGL149W TIP20 FLC3 RPL1B CDC43 NUT1 ARO2 HUL5 SEC27 PCL10 YGL132W ITC1 CEG1MET13 COQ8 CDC20 YGL114WNSA1 SCS3 RPS2 YGL117W SNF4SLD3 30M 60M 90M 0.120M 0.150M 0.180M 0.210M 0.240M 0.270M RTG2 RAI1 YGL239CMTO1YGL230C OST5SDT1 EDC1 MDM34SKI8 th(gug)g1 KEX1 EMP24 YGL194C-A YGL193C YGL188C RPS26A TPN1 YGL182C STR3 YGL176CXRN1 tk(cuu)g2 YGL165C RAD54 LYS5 INO80RRT6 MRF1 YGL140C MRM2 RSM23 SOH1 YGL123C-A GPG1 tw(cca)g1 HFM1 YGL242C HAP2 EMC4 SAP4 tv(aac)g3 COG1 YGL217C NIF3 CHC1 YGL204C MCM6 YGL199C HOS2 YGL188C-A CDC55 COX4 YGL185C MND1 TOS3 SAE2 SPO74 PMR1 YRB30 YIP5 YGL152C RPL9AROG1 GPI10 YGL138C SNT2CWC23MON1 NAB2 PRP43 YGL118C TAF6 30M 60M 90M 0.120M 0.150M 0.180M 0.210M 0.240M 0.270M ARS716 ARS717 ARS718 ARS719CEN_chr7 ARS720 ARS721 ARS722 YGL109W ARC1 YGL101W th(gug)g2 LSG1 TOS8 SPC105 LIF1MAD1SCY1 YGL081W KXD1 AFT1 NPY1 PUS2 YBP2 RAD6 MST27 PRM8 TYW3 YGL041W-A RIM8 YGL039W HOP2 CGR1 STT3CKB1 KAP122 ERG4 BRP1PMC1 CUL3 PRP18 YGR012W NMA2 NSA1 MLC1 RPL28 SEH1 USE1SRM1SOE1 NUP145 YGL088W LCL3 YGL082W FMP37 HSF1MNP1 SGF73 PYC1 PKP2 OLE1 tr(ucu)g1 YGL052W ALG13 DST1 SUP54 YGL036W RPL30 YGL024WALK1ATE1 PUF4YGL010W YGL006W-A ERP6 PEX31 ECT1 YGR011W SNU71 MSB2 YGR017W YGR021W td(guc)g1 YGR026W MSP1 IMO32 RPL26BORM1 KSS1 YGR042W UFD1 FMP48MUP1 YGR016W UGA1 YGR025W MTL1tE(UUC)G3 ERV1 GSC2 YGR035W-A YGR039W BUD9TAM41SCM4 YGR054W 0.300M 0.330M CUE3 RMD9 YGL102C YGL108C VPS73 VPS45 PAN M 0.390M MF(ALPHA)2 GUP1 HNM1 MPS2 YGL072C YGL069C MRH4 DUO1tE(UUC)G2 SDS23 NBP35 MMS2 DBP3 RPL7A YGL074CRPB9 YGL063C-A ALG2 GEP7ERV14 TIF4632 tv(aac)g1 RPT M 0.450M 0.480M YGL041C-B RNA15 HEM2 PNC1 YGL034C RPL24A SCW11TRP5 PIB2 JAC1 YGL014C-A SCL1 YGL042C YGL041C OCH1MIG1 tf(gaa)g AGA2 CWH41 PGD1 GET1 YGL015C PDR1 YGL007C-A LEU1 PMA M 0.540M 0.570M COG7 CDH1 YGR001C TFG2SEC9 YGR018C YGR022C RPS25A POP6 TIM21 ts(aga)g CAX4 RME1 TFC4 YGR051C RPN14 ERG26 SWC4 STF2 YGR015CVMA7THG1 td(guc)g2 NAG1 YGR035C ACB1 YGR045C NQM1 YGR050C YGR053C RSC1SPR3 YGR064WYGR069W UPF3 YGR079W TOM20 MUP1PEF1 ERG25 YGR068W-A ROM1SMD1 TWF1 ARS727 ARS728 ARS729 ARS731 ARS731.5 CTT1 tt(ugu)g1 NNF2 UTP22DBF2VAS1ASK10 PRP31 YGR093WTPC1 TEL2 MDR1 tl(gag)g NOP7 CLB1 YGR111W DAM1RPS23A YGR121W-A tr(ucu)g3 PCP1 VMA21 YGR107W CLD1 SHY1SPT6 tn(guu)g YGR122W ti(aau)g YGR125W ASN2 YGR126W SYF2 PEX4 YGR137W PRE9 YGR127W FHN1 CAF130 YGR139W LSB1 CBF2 BTN2 ta(agc)g VPS62 SKN1 THI4YGR149W YGR153W PTI1 YGR160W SUF4 ENP2 ta(ugc)gcys4 CHO2 YGR161W-C tv(aac)g2 MRPS35 TIF4631 YGR164W GTR2 CLC1 YGR174W-A RBG2 TIM13 tk(cuu)g3 SKI6 TRS65 PSD2 tg(gcc)g1 YGR176W TFG1 HIP1 YPP1 PMT M 0.630M 0.660M 0.690M 0.720M 0.750M 0.780M 0.810M 0.840M LST7 COX18 VHT1 YGR067C ENV11 PRP38 PEX8SLX9 MRP13 PIL1 RRP46 GTF1VOA1 CLB6 YGR114C YGR117C YGR122C-A COG2 UTP8 PHB1 ECL1 NAT2CCM1 RSR1 MTR3 RTS3 YGR168C YGR169C-A YIP1ERG1PBP1 YGR182C RNR4 ADE6 SPT4 YGR066C ART5 YGR073C MRPL25 PAC10GCD2 RPL11B PDC6 ESP1 tk(uuu)g2 SRB5tC(GCA)G YGR115C NUP57 MEP1PPT1 YGR130C TPO2 YGR146C-A RPL24B YGR151C GTO1 NSR1 tr(ucu)g2 PUS6 MSM1 CBP4 ATF2 tl(caa)g3 OKP1QCR9 UBR M HGH1YGR190C CRH1 PDX1FYV8 ELP2 TYS1 tw(cca)g2 BUB1 TDH3 XKS1 SNG M 0.630M 0.660M 0.690M 0.720M 0.750M 0.780M 0.810M 0.840M 0.870M

10 chrvii_2 ADE3 MVB12ZPR1 RPS0A CCH1YGR219W AZR1DIE2BNS1 YHB1 YCH1 TDA10 SER2SLI1RSM27 CRM1PET54YGR228W AMA1 NAS6 ARS733 ARS734 ARS131a FMP43 SOL4 NOP19ENO1 GND2 YGR265W YGR269W SLH1 CWC22 MAL13MAL12 YRF1-3 YGR242W CPD1 MGA1 GCN5 tt(ugu)g2 TNA1 YGR266WYTA7 RTT102 YOR1 YGR290W PAU M 0.930M 0.960M 0.990M 1.020M 1.050M 1.080M ELP2 PCT1 YGR210C CIR1 GPI1 MRPL9HSV2 SMI1PHO81SPG1KEL2YAP1802 PFK1 SDA1 YGR250C COQ6RAD2 APL6 SAY1 YGR270C-A FOL2 YGR273C RNH70 SCW4 BGL2 ERV29 BIO2 MAL11 YGR293C YGR296C-A YGR201C YGR204C-A TRX2 RTA1 tg(gcc)g2 TOS2YGR226CPHB2 YGR237C MOS2 PEX21 YGR240C-A LSC2BRF1 PUP2 MTM1 YGR259C BUD32 MES1HUA1 EFG1 TAF1CAB4PXR1YGR283C ZUO1 IMA1 YGR291CCOS6 YGR296C-B 0.900M 0.930M 0.960M 0.990M 1.020M 1.050M 1.080M

11 chrviii ARS131n ARS802 ARS805 ARS805.5CEN_chr8 ARS807ARS808 ARS809 ARS810 ARS813 ARS815 COS8 YHL045W ECM34 YHL041W MUP3YHL030W-A WSC4SNF6 th(gug)h YHL018W YHL015W-A YHL012W MRP4 RPL14B QCR10 STP2 DIA4 SPO13 MIP6 YHR020W MYO1VMA16 YHR033W ERC1 BRL1 RRF1 NCP1 YHK8 YHR052W-A SMF2 COX6 YHR056W-A VMA22 SSF1 DYS1 YHR073W-A PCL5 NOP10 PTC7 LRP1 STE12 YHL050W-A YHL046W-A YHL044W YHL042WEFM1YHL034W-A ECM29 RIM101RIM4YHL019W-A YHL017W RPS20 YHL006W-AHSE1 OSH7 LEU5 RPL27A VPS29 tq(uug)h YSC83 ECM12 THR1 YHR028W-A YHR032W-A YHR035W PUT2BCD1 YHR045WYHR050W-A FSH1 YHR054W-A CIC1 YHR063W-A FYV4 HTD2 TRM5 ERG7 OSH3 QNS1 YHR078W SAM35 IPI1 NAM8 RTC3 AHT1 YHR086W-A RPF1 YHR095W 30M 60M 90M 0.120M 0.150M 0.180M 0.210M 0.240M 0.270M YHL050C YHL048C-APAU13 CBP2VMR1 RPL8A GOS1 YHL026C SPO11 OPI1 DUR3OTU2 tv(aac)h ETP1 STE20 YHL005C YHL002C-A NEM1 TIM10 ERG11 SOD2 ARD1YSC84 DED81 YHR022C-A RPS27B RPN1YHI9RRM3PIH1 VMA10DOG2 INM1 YHR049C-A YHR054C RSC30 MED6 RPP1 SSZ1YHR070C-A YHR071C-A RRP4 PPE1 IRE1 YHR080C GAR1 MSR1HXT1 YHR097C YHL049CARN2 ARN1 YHL037C SBP1 GUT1 OCA5 NPR3 AIM17 APM2 YLF2PRS3 YAP3 YHL008C SHU1 LAG1YHR003C tt(agu)h GPA1 YHR007C-A TDA3 ts(aga)h ARG4 ta(agc)h YHR022C MAS2 DAP2 YHR032C-A SLT2 MSC7 SRB2DOG1AAP1 CUP1-1 CUP1-2 CPR2 GIC1 PAN5 RRP3 YHR069C-A tf(gaa)h1 YHR073C-B NMD2 SAE3 KSP1 YNG2 HXT4 HXT5SFB3 30M 60M 90M 0.120M 0.150M 0.180M 0.210M 0.240M 0.270M ARS818 ARS820 ARS822 ARS823 ARS823.5 ARS824 KIC1 GRE3 TRR2CTM1 UBA4BZZ1 TOM71 YHR122W TRA1 SBE22 YPT35 GGA2 ERP5APE4 COX23SET1 MSH1 NDT80 YHR127W YHR131W-A WSS1YHR140WDSE2CRP1PEX28 RTT107 REC104 MPC2 YHR165W-A MTG2 NMD3 SPC97 CTR2 FMO1 LSM12 YHR125W EPT1 FUR1 IGO2 ARO9 CHS7 RPC10 IMP3 SPO12 YSP1 TDA11SOL3 THP2 DBP8 ATG7 YHR175W-A ENO2 YHR177W STB5 YHR180W tt(ugu)h YHR182W SSP1 PTH1 LNP1 NVJ1 RIX1YHR202W SCH9 BAT1 FLO5 YHR213W-B YHR214W-A YHR218W-A IMD2 YHR180W-A OYE2 SVP26 GND1 IKI1ERG9 MDM31 UTP9RPN10 MNL1SKN7 CRG1 YHR212W-A YHR213W-A YHR214W PHO12 YHR218W YHR219W 0.300M 0.330M 0.360M 0.390M 0.420M SFB3 BIG1 YHR112C ORC6 ANS1 YHR130C ECM14 YHR137C-A YCK1 SPS100 RPL42B SUF8 MRPL6 MTC6 LIN1 PEX18 DNA2 GEP4 CDC12 DMA1 tf(gaa)h2yhr131c ARP1 NSG1 YHR138C YHR139C-A SPL2 YHR145C DCD1 SKG6SPO16 KEL1 YAP1801 PRP8 CDC M 0.480M YHR180C-B PFS1 YHR173C YHR182C-A tv(cac)h KOG M 0.540M YHR193C-A CTF8 AIM46 PPX1 SET5 YHR212C YHR214C-E YHR219C-A GPI16EGD2 AIM18 NBL1RPS4B YHR210C YHR214C-D YHR217C 0.300M 0.330M 0.360M 0.390M 0.420M 0.450M 0.480M 0.510M 0.540M

12 chrix YIL177W-A YIL177C PAU14 VTH1 YIL171W-A SUC2 YIL156W-A BNR1UBP7 YIL152W YIL161W YIL156W-B AIM20 RRD1 ARS907 ARS909 ARS911 ARS911.5 ARS912 ARS913 ARS913.5 ARS914 TID3 YIL141W OM45 ASG1 STH1 AYR1POG1 QDR1 HIS5 SDP1 COX5B YIL108W YIL105W-A tt(agu)i1sga1 PRK1 te(cuc)i ICE2 ti(aau)i2 SEC28YIL071W-A YIL066W-AYIL060W SUP17 YIL054WPCL7 NEO1MET30GVP36 TED1 YIL029W-A ULP2 RPL40A CCT2 AXL2 FLX1 MET18 KGD1 SIM1QDR2YIL115W-A RHO3 HOS4 HPM1 MOB1DPH1 YIL100W FYV10YIL092W YIL089W YIL082W THS1 YIL068W-A HOP1 SEE1 YIL058WVHR1RHR2 DFG10 YIL046W-A PIG2APQ12 CST6 YIL030W-A 30M 60M 90M 0.120M 0.150M 0.180M 0.210M 0.240M IMA3 YIL166C NIT1 POT1 GUT2 YIL151C MLP2 ATG32 SSL2 REV7 TMA108 YIL134C-A CSM2 TAO3 RPI1 NUP159 SEC24 YIL102C-A SLM1 XBP1 ti(aau)i1 FMC1 RSM25 YIL086C AVT7 SDS3 AIR1 RPN2 SPO22MAM33 SEC6 YIL169C YIL165C YIL163C COA1IMP2' MCM10 SLN1PAN6 YIL142C-A TPM2VHS2 RPL16A FKH1 RRT14 PRM5 POR2 PFK26 SHQ1 YIL102C YIL100C-A YIL096C LYS12 UTP25 AIM19 KTR7 CAB2 YIL077CSER33 PCI8 RPS24B YIL067C RNR M YRB2 SNP1 RGI2 RPL34B YIL047C-A AGE2 PKP1 PRM2 YIL032C CAP2 FIS1 ARC15 YIL059C YIL055CMMF1 SYG1 CBR1 NOT3 CKA1 BCY1 SSM4 30M 60M 90M 0.120M 0.150M 0.180M 0.210M 0.240M 0.270M ARS916 ARS919 CEN_chr9 ARS920 ARS922 YIL028W RPB3 RPL2B BAR1 MNT3 TIR3 FAA3YIA6CFD1 YIL001W DJP1 te(uuc)imsl1 YIR017W-A SQT1 RPR2 YIR020W-A YIR021W-A DAL81YIR030W-A DAL4 YIR036W-A PAU15 YIL029W-A TIM44 FAF1tT(AGU)I2 SNL1 YIL012W DOT5 URM1 YIL002W-A EPS1 AIM21 IST3 YIR007WDSN1 YIR014W YIR016W YAP5 SEC11 MRS1 MND2 DAL2 MGA2HYR M 0.330M 0.360M 0.390M YIL029C SSM4 YIL024C IRR1 YIL021C-A HIS6tD(GUC)I1PDR11 td(guc)i2 BET1 SGN1 PAN1 STS1MET28 tk(cuu)i EMC5 YIL025C YIL020C-A YKE4 VID28 YIL014C-A EST3 NAS2 INP51 MPH1 PRI1 YIR018C-A GAT4 FLO M YIR020C-B YIR024C DAL1 DAL7 LYS1 IRC24 YIR020C YIR023C-A YVH1 DCG1 DAL3 YIR035C GTT1YIR040C YPS6 YIR042C 0.300M 0.330M 0.360M 0.390M 0.420M

13 chrx ARS1001 ARS1002 ARS1003 ARS1004 ARS1005 ARS1006 ARS1007 ARS ARS1008 ARS1009 ARS ARS1010 YJL222W-B YJL225W-A YJL222W-A VTH2 HXT9 REE1YJL213W CBP1 ECM25 UBP12 YJL193W RPL39 YJL181W GON7RPL17B KRE9 YJL169WQCR8 HSP150 YJL152W DAS1YJL144W IDS2 RPB4 YJL135W MRS3 YJL127W-A YJL118W ALB1 ASF1 MDV1 IME2PAM16 tr(acg)j CHS6PHS1 BCK1 SIP4 EXO70 IML2 YJL077W-A YJL220W YJL218WHXT8 PEX2 PRP21 PHO90 CDC6 RPS14B MNN5 MNN11 PFD1 YJL175WCPS1ERG20 FMP33 YJL156W-A YJL150W RPA34SFH5 TIM17 YJL136W-A LCB3 YJL132W NIT2 YJL120W PHO86tD(GUC)J1CCT7 SET4 MEF2LSB6 SAP185 MRPL49 SRS2 ARG3 TAX4 YJL077W-B NET1 30M YJL225C IMA4YJL215C YJL211C PAU1 IMA5 OPT1NUC1 LAA1 60M 90M 0.120M 0.150M NCE101 YJL202C tt(agu)j YJL197C-A YJL195C RPS22A SWE1 YJL182C ATG27 RFA3ASG7 HAL5 YJL163C te(uuc)j CIS3 SSY5 VPS35 SNA3 IRC9YUR1 YJL133C-A GLG2 YJL206C RCY1ACO2 MBB1 ELO1SOP4 BUD19ATG36 ATP12SWI3 YJL171C SET2 TPK1JJJ2 YJL160C FAR1 FBP26INO1 YJL147C YAK1TIF2 RPS21B AIM23 URA M TRK1 YJL127C-B PBS M 0.240M 0.270M SPT10 LSM1 RPE1 NCA3 GZF3 PRM10 GSM1 KHA1 GWT1 TRL1 GCD14 YJL119C MTC1 ta(agc)j UTP10 YJL107C GSH1 TOK1 DPB11YJL086C ALY2 SCP160PRY3APQ13 ARP4PRY1ICS3 SMC3 30M 60M 90M 0.120M 0.150M 0.180M 0.210M 0.240M 0.270M ARS1011 ARS1012 ARS1013 ARS1014 CEN_chr10 ARS1015 ARS1016 ARS1017 ARS ARS1018 ARG2YJL064W LAS21BNA3YJL055W PEP8IRC8 YJL049W td(guc)j2 SUP7 YJL043W NSP1 tv(aac)jkar2 YJL032W YJL028W RRN7 YJL020W-A YJL016W tk(cuu)j EMT3 COX16 AVT1 APL1SUI2 MET3 TMA22 YJR018W LSM8 PET191 YJR037WGEF1 TAH11 tg(gcc)j2 ISY1 BFA1 td(guc)j4 HSX1 PTK2 YJR061WCCT5 RFC2MOG1BNA2 YJR084W YJR087W BUD4 JEM1 YJL067W COA3 NUP82 YHC3 TIM54 TDH1 MTR4 tr(ucu)j1 AIM22 YJL045W MHP1 IRC18 SNX4HCA4 MAD2RNR2 YJL022WMPS3 CCT3 YJL009W CYR1 PRE3 MPP10 POL31 MHO1GPI14 YJR015W YJR020W CPR7 RAD26 YJR039W NUP85 CYC1 OSM1 RAD7 YJR054W HIT1 CDC8CBF1RPA12 TOR1 YJR071W HOC1 YJR079WSTE18 BIR M 0.330M SMC3 YJL070C YJL068C DLS1 BIT61 PSF2UTP18 MPM1 MRPL8 IKS1 ZAP M 0.390M 0.420M 0.450M 0.480M 0.510M 0.540M 0.570M UBX6 RTT101 tr(ucu)j2 NUP192 TAD2 VPS53 YJL027C PET130 APS3 YJL015CtW(CCA)J VTC4 CCT8 CTK2 SYS1 YJR003C YJR005C-A YJR012C SPC1 REC107 ESS1 MDE1 YJR030C RAV1 YJR038C POL32 VPS55 ts(aga)jutr1 SUP4 NTA1 YAE1 LIA1 OPI3MIR1 YJR085C EAF6 GRR1 YJL052C-AYJL047C-A GYP6 td(guc)j3 LOH1 BET4 YJL026C-A tg(gcc)j1 EMT5 BBC1 MAD3 RPC17 NOP9 YJL007C SUP51 OST1 SAG1 TDH2 YJR011C ILV3 YJR023C TES1 BNA1 GEA1 HUL4 URB2IMT3 SSC1ANB1 YJR056C APS2 ARP3 HAM1 NPA3 CDC11 AIM24 ACF4 EMC2 JSN1 ARS ARS1019 ARS1020 ARS1021 ARS1022 ARS1023 ARS1024 ARS1025 RPL43B YJR096WYUH1 RSM26ADO1 YJR107WYJR112W-A YMR1 YJR115W STE24ATP2 RPS5 MNS1 XPT1 IML1 YJR141W MGM101 YJR149W HMS2 DAL5 YJR154W YJR157W BUD4 SFC1 JJJ3 tl(uag)jura8 ECM27 ABM1YJR114W NNF1 TDA4 YJR120W IBA57 YJR128W NMD5TIM8 YJR140W-A YJR142W YJR146W BAT2YJR151W-A PGU1 AAD10 HXT16 SOR M 0.630M 0.660M FIP1 YJR098C VPS25 CPA2 RSM7 JHD2 ENT3RSF2STR2 MCM22 IME1 AIM25 SOD1 YJR111C ILM1 YJR124C VPS70 YJR129C SGM1 TTI2 MET M HIR3 RPS4A HOM6 PMT4 DAN1 DAN M THI11 MPH3 YJR162C COS M 0.630M 0.660M 0.690M 0.720M

14 chrxi YKL223W COS9 YKL225WMCH2 PAU16 FRE2 YKL222C SRY1 JEN1 URA1 ARS1103 ARS ARS1106 ARS ARS UBA1 EMC3 SAC1 CBT1 LOS1 EAP1 tn(guu)ktl(uaa)k DPH2 ASH1 LOT5 PRS1 YKL177W SNU114 NNK1 PIR3 APE2 SRP102MCR1 RPT1 LTV1 SDH3 YKL136W CTK1 tk(cuu)k YPK1SSH4 DGR2 YKL118W SBA1 YKL107W HAP4 YKL202W MIA40 CNB1 HYM1 SPE1 FAS1 RPL17A ZRT3 EBP2 MRPL38 ELF1 RPS27A YKL153WYKL145W-A AVT3 MRP8 TGL1CMC1 YKL131W PGM1 YKL123W RRN3tA(AGC)K1 OAC1 ABF1 SLD2 AAT1 HSL1 MTC2 CWP1 YJU3 CUE2 CAB3 YKL083W MDH1VMA5 DHR2 LHS1 YKL100W-ACWP2 YJU2 MBR1 MIF2SRX1 HOT13 TEF4SMY1 YKL077W STB6 30M 60M OXP1 DOA1 STE6 ADD66 MNN4 YRA2 TRP3 TRT2 TOR2 PTK1 PEX1 90M 0.120M MST1 ACP1 YKL187C YKL183C-A STE3 TPO5 KKQ8 TPK3 YKT6 SDS22 PXA2MTR2 COY1 LST4 YKL169C YKL165C-A MRP49 te(uuc)k MCD M 0.180M 0.210M 0.240M 0.270M PIR1 YKL162CRCN1RSM22 GPM1 DBR1 YKL147C HSK3 APL2 YKL133C SHE2PMU1 VPH2 YKL115C RAD27 KTI12 SEG2 APE1YKL100C YKL097C BUD2 CYT2 YKL162C-A KDX1 YKL156C-A tr(ucu)k YKL151CSDH1RPC25 MRPL31 OCT1 RMA1 MYO3 SRP21 PRR1 APN1 YKL111C YKL106C-A GFA1 YKL102CYKL096C-B UTP11 YKL091C RRP14 PSY1 MUD2 YKL075C 30M 60M 90M 0.120M 0.150M 0.180M 0.210M 0.240M 0.270M ARS1109 ARS1112 ARS1113 CEN_chr11 ARS1114 ARS ARS1116 ARS1118 tw(cca)k YKL070W YKL068W-A YKL065W-A YNK1 MSN4TOA2 SFK1 PRI2 PHD1 VPS24 STB6 YKL071W YKL069W NUP100 YKL066W MNR2 BLI1 YKL053W YKL047W YKL044W SPC42 PTM1 RGT1 YKL033W-A UGP1 tv(aac)k2 YKL030W YKL027W RAM2 PUT3 MRT4 RPL14ADID4 OSH6 RSC4 PRY2 VPS51 YKR023W tr(acg)k SAP190 YKR032W DID2 ta(agc)k2 UTH1 YKR047W YKR051W TRM2 GLG1 UTP30 TFA2 GPT2 YKR070W AIM29 YKR078W ECM4 NUP133 AIM26 TUL1 TTI1 YKL031W TFA1YKL023W SWD2 PRP40 CAP1 AUR1 PAP1 MEH1 tl(caa)k FCJ1 ALY1 RPC37 BCH2 GMH1DAL80 YKR041W GAP1 UIP5 TRK2 RHO4 RPS21A TIF1 KTR2OAF3 MET1 tk(uuu)k YKR075W-A MSA2 MTD1 PRP16 tv(aac)k1 YET1 FBA1 NUP120 OAR1 MDM35 YKL050C ELM1 NFU1 IXR1 GPX1 URA6 CDC16 SPT23HCS1 URB1 CCE1 LAC1 BYE1 MET14 ECM9 MRPL13 TOF2 YKR012C YKR015C YKR018C NTR2 GCN3 SPO14 OPI8 td(guc)k SPC34 SHB17 PET10 FMP46 YSR3 LAS1CCP1 YKR073C DRE2 TRZ1 DAD2 MRPL20 th(gug)kykl063c MPE1TMA19 DEF1 ASK1 CSE4DCW1 YKL036C MAE1 YKL023C-A PAN3MAK11 YKL018C-ATP7 ARC19UFD4 SFT1 MRP17 VPS1YKR005CFOX2 YKR011C YPT52 HEL1IRS4 DBP7 SET3YKR033C CAF4 KAE1 YKR040C YKR045C NAP1 MRS4 DYN1 PAM17BET3 YKR075C SIS2 RPF2 HBS1 ARS1120 ARS1123 PXL1 PTR2 PRP16 SRL3 MLP1 YKR096W PCC1PCK1 SIR1 NFT1 GEX2 BAS1 FLO10 YKR104W 0.600M 0.630M 0.660M OMA1 TGL4 RPL40B SKG1 TVP38 SRP40 UBP11 VBA M 0.630M 0.660M

15 chrxii_1 YLL066W-B YLL065W YLL058W YLL067W-A YLL066W-A MMP1 YCT1 LDB18 YLL044W YLL047W FPS1 YLL037WIRC19 GRC3 ARS1206 FRA1 TPO1 HSP104 PAU17YLL019W-A ISA1 tp(ugg)l SPA2 CEN_chr12 ARS1208 ARS1209 EMC6 SOF1 YLL006W-AORC3 RTT109 SSL1RLP24GAT3 MEU1 IRC25 BPT1 YEH1 DRS1MMM1SFI1DNM1 NSE1LOT6 BRE2PSR2 YLR030W RAD5 SNF7 YLR031W RSC58 ARS1210 ARS1211ARS ARS1212 YLR041W IES3 MNL2 RPL22A PER33FYV7 RPL10 SIC1GAL2 RPS0B ERG3 YLR063W FRS1SPC3 YLR072W FMP25 EMP46 30M 60M 90M 0.120M 0.150M 0.180M YLL067C PAU18 MHT1 YLL059C YLL056CYLL053C FRE6YBT1 RPL8BSDH2 UBI4 PRP19YLL032CRRT7 POM33 YLL020C COX19 PUF3 COX17 SPO75 NOC3 THI73tS(AGA)L PAM18 PPR1POM34SDO1 YLL066C AYT1 GTT2JLP1YLL054C AQY2 COF1 RNP1 ATG10 VPS13 ENT4RIX7 GPI13 SSA2 HIF1 KNS1 DPS1 PSR1 YLL007C YLR001CMS1SSK1 YLR012C TEN1 PML1YEH2 IZH3 UBR M AAT2 RPL15A MLH2 SED5 ADE16 ta(ugc)l SMF3 YLR036C 0.240M 0.270M COX12 YLR040C TRX1STU2 FRE8 YLR050C YLR053C SPT8 REX2ENV10MEF1 RGR1 BUD20 BOS1 PAU23 YLR042C RIC1 PDC1 YLR046C YLR049C FCF2 OSW2 SHM2 BUD28 PET309XYL2YLR076C RFU1 EMP70 SRL2RAX2 30M 60M 90M 0.120M 0.150M 0.180M 0.210M 0.240M 0.270M SMC4 GAA1GEP5 XDJ1 SUL2 ARS ARS1213 ARS1215 ARS1216 ARS ARS1217 KIN2 ERG27 REX3 YLR111W HOG1 CFT2 SRN2 YLR124W DCN1 CKI1SLX4NHA1 td(guc)l1 RRN5 RMP1 PEP3 YLR154W-A YLR154W-F TAR1 YLR157W-E YLR159W YLR161W YLR162W YLR163W-A YLR171W RPS31 IDP2 YLR177W SWI6 RPL37A SKG3 MMR1 PWP1 YKE2 ENT2 SEC13 FRE1 MSC3 YLR224W MIM2LCL2 YLR112W AHP1 tr(acg)l MSL5 YLR120W-A YLR125W DIP2 PDC5RKM5 YLR140W YLR143W PUT1 YLR146W-A STM1 YLR154W-B YLR154W-E YLR156W YLR157W-D RRT15 SHH4 YLR169W YLR173W CBF5 SAM1 YLR184W EMG1MDL1 PEX13 NOP56QRI5 HRD3 CLB4 YLR217W CCC1 BUR M 0.330M RAX2 CSF1 NYV1 ARP6 ALT1 GIS3 IOC M 0.390M 0.420M 0.450M CHA4 YLR101C CDC45 MDN1 CCW12 CLF1 YPS1 YLR122C YLR126C ZRT2USB1 SLS1 SPE4 YLR149C PCD1 tq(uug)l ACS2 YLR154C-G HRT3 ICT1 APC9 SEN2 YLR108C AVL9YLR118C YLR123C YPS3 APC2 ACE2 TIS11 ACF2 SMD3 YLR149C-A YLR152C RNH M 0.510M 0.540M 0.570M ASP3-1 ASP3-2 ASP3-3 ASP3-4 PUS5UPS2 DPH5 TFS1 VTA1 ATG26 UPS1 NMT1 YLR202C PBA1HMX1 YLR211C CRR1CPR6 YLR222C-A RSA3 YLR225C tl(uag)l1 YLR154C-H YLR156C-A YLR157C-C YLR159C-A MAS1 SEC10 APS1 RFX1 YLR179C TOS4 YLR194C HCR1YLR198C COQ9 MSS51 PNP1 TUB4 CDC123 COA4UTP13 IFH1 ADY4 ARS1218 ARS1220 ARS1223 ARS1226 ARS YLR232WTHI7VPS34 YLR243W tl(caa)l YLR230WTOP3 FAR10 YLR241WERF2 RCK2 YEF3 YLR253W SYM1 YLR257W LCB5 RPS28BSEC22 YLR271W SMD2 YLR283W YLR286W-A YLR296W ECM38 HRI1 MET17 UBC12 CDA2 NKP2 EST2 VPS65 YLR326W NMA1 td(guc)l2 CHS5 NUP2 RPP0 SSP120 YLR252WHAP1 GSY2 RED1 BOP2 DCS1 MCM5 YLR279W NNT1 GUF1YLR297W tl(uag)l2 ti(aau)l1 EXG1 CDA1 MRPL15 YLR317W MMS22 PEX30 tx(xxx)l REC102 MID2 te(uuc)l OPI9 SPO77 FKS1 GAS2 RPL26A YLR347W-A ORM2 YLR342W-A YLR345W TRR4YLR349W YLR352W BUD8 RSC2 VPS38 YLR363W-A YLR365W RPS22B SSQ1 SUR4 tk(uuu)l CSR1 SMC6 RPS29A ATG33 ADE13STE11 YLR366W GRX8 MDM30ROM2 STP3 YLR379W CTF3 VAC M 0.630M 0.660M 0.690M 0.720M ECM22 ti(uau)lylr236c EST1 ARV1 CDD1 NDL1 ta(agc)l VPS63 TMA7NEJ1 YLR269C tv(aac)l DBP9 YLR278C YLR281C ECI1 CTS1 RPS30A YLR290C YLR294C SEC72YHC1 YLR302C CDC42 BNA5 YLR235CLIP2 MAP1 IRC20 YLR255C HSP60 YLR264C-A YPT6 PDR8 YCS4 PIG1 YSH1 YLR280C YLR282C YLR285C-A YLR287C MEC3 GCD7 ATP14 GSP1 YLR299C-A ACO1 STT M 0.780M 0.810M 0.840M 0.870M IMH1 YLR311C SPH1 TAD3 SFH1 RPL38 JIP3 YLR334C VRP1 YLR346CDIC1 TAL1 YLR358C YLR361C-A YLR364C-A VID22 PSY3 SEC61 IKI3 REH1 YLR307C-A CDC25 YLR312CDC3 BUD6 CWC24 TMA10 RPS25BSGD1 YLR339C KAP95NIT3 ILV5 DCR2 NMD4 ARC18YLR374C FBP1 NAM2 SWC7 STE M 0.630M 0.660M 0.690M 0.720M 0.750M 0.780M 0.810M 0.840M 0.870M

16 chrxii_2 ARS1232 ARS1233ARS1234 ARS1235 CCW14 CST9 YLR400W SFP1 DUS4 VIP1 BER1 VPS36 URA4 SPP382 TDA5 CRN1 IMD3 CAR2 YLR446W ECM7 FPR4 LEU3 YLR455W YLR458WPAU4 YLR464WYRF1-5 ECM19 ATP10 YLR399W-A YLR402W FLD1 YLR407W CTR3 YLR413WYLR419WYLR422W TUS1MAG2 SEN1 TSR2 MRPL4 GMC2 RPL6B HMG2 FMP27 YLR456W GAB1YLR462W YRF M 0.930M 0.960M 0.990M 1.020M 1.050M STE23 COX8 AFG2 BDF1 RPL31B BLS1 YLR412C-A YLR415C CDC73RPN13tN(GUU)L ATG23 YLR434CDIF1 LSM3 RPS1A YLR444C SST2 ti(aau)l2 YLR460CYLR466C-B BSC3 ART10VPS33 SKI2 DUS3 YLR406C-A UTP21 YLR416C PUN1 tl(uaa)l ATG17 YLR428C CNA1 YLR437C-A ECM30SEC39 SIR3 VMA6 RIF2 NBP1 YLR463C YLR466C-A YLR467C-A 0.900M 0.930M 0.960M 0.990M 1.020M 1.050M

17 chrxiii_1 YML133W-A YML131W YML133W-BCOS3 RSC9 YML133C ARS1303 ARS1304 ARS1305 ARS1307 ARS ARS1308 ARS1309 CEN_chr13 ARS1310 GTR1 YML116W-A NGL3 DAT1 BUL2 YML108W CAC2 TSL1TAF13GIM5YML090WYML084WTDA9 YML079W BET5 POB3 ORC1 OGG1 SML1SPC2SUR7 AIM32 YML047W-A CAT2 SRC1RCF1 TSA1 RPS17A YML020WPSP2 UBX2 SPT5YAP1YML003W YPT7AIM34 TAF4 ADI1HXT2 YML119W NAB6 ATR1 CTK3 ZDS2 URA5 YML100W-A YML099W-A YML096W UTP14 UFO1YML082WDUS1 CPR3 DAK1 ITT1 RPS1B HUG1 CMP2 SUP5 GAL80 GSF2 PRP39 CGI121 NDC1 USA1 YOX1 APT1OST6 TRM9 YML009W-B ERV25 TRM12 YML002WMIC17 MVP1 YMR007W YMR010W te(uuc)m YMR013W-A CLU1 BUD22 30M 60M 90M 0.120M 0.150M 0.180M COX14 ERG13 YML122C TUB3 VAN1 COQ5SEC65NUP188 CUE4 YML094C-A VPS9 RPM2AIM33 TUB1 ATP18 HMG1 RPL6A COG8 ERV41TEM1PIF1YML057C-AYML053C CYB2 PRM6 ERO1 MSC1PGA3 PHO84 NDI1 TAF8 PML39MDM1 YML101C-ARG81RAD10 PRE8 YML089CALO1 YML083C WAR1 FPR3tR(UCU)M2 TCB3 SMA2 MFT1 NTE1 YML054C-A IMD4 RSE1 tg(gcc)m RRN M 0.240M 0.270M SUF7YML037C YML034C-A YML031C-A YML6UNG1 YML012C-A PPZ1YML009C-A ERG6GIS4GLO1 YMR001C-A PLB1 VPS71 YMD8 AMD1 RAD52 RPS18B NSE5 YML018CTAF11 RAD33 YML007C-A MRPL39 ts(aga)m CDC5 PLB2 SEC59 YMR013C-A 30M 60M 90M 0.120M 0.150M 0.180M 0.210M 0.240M 0.270M ARS1312 ARS1316 ARS1319 ARS1320 ARS1322 SPO20STB4UBC7CSI1 TAP42 YMR031W-A YMR030W-A IMP2 tf(gaa)m MCM1 YMR046W-A CSM3 STV1SEN15 RIM9 KAR5 AVO2 MOT3RCO1 YMR085W ADH3 YMR087W UTP15 SNZ1 MUB1 SPG4 BUD22 YMR018W FMS1MRPL3 YMR027W RSF1HOF1 ARP9 YET2 ARG80 IOC4 th(gug)m FAR3 FET3 RNA14AEP1SOV1NAT4 ABF2 SEC14 YMR084W SEG1YMR090WCTF13 td(guc)m YMR105W-AILV2 MYO5 MGR3 YMR122W-A FOL3tL(CAA)M YMR119W-A ASI1 YMR124W ECM16 YMR130W YMR134W GAT2 YMR141W-A RIM11 YMR144WOSW5 YIM2 NUP53MRPS8 YMR160W PKR1STO1 POM152 YMR135W-A REC114 CIN4 SIP5 RPS16A YMR147W SWP1 YIM1 YMR155W YMR158W-B HLJ1 ERG5 ta(agc)m1 MAC1 FAR8 YMR034CMSN2 SUB1 NUP116 tv(aac)m1 YMR052C-A YMR057C BUB2 ARG7 YMR074C TVP18 PDS5 VPS20 NAM7 YMR082C VBA1 NPL6 SNO1 ATP25 SRT1 YMR103C tk(cuu)m PGM2 YMR111C YMR114C SPC24ADE17 YMR122C SAS2 JLP2 PSO2 RPL13B TIF34 YMR153C-A TPP1 EMT4 ATG16 SOK2 MSS1 PEX12 EIS1 MIH1CCS1 ARA2 ERB1tW(CCA)M STB2 AAC1 SAM37 UBX4YMR075C-A IRC21 tv(aac)m2 CTF18 ISF1 YMR086C-A YTA12AIP1 MTG1 YMR099C YMR102C YPK2 YKU80 HFD1 MED11ASC1 SHH3RPL15B DLT1 RRB1GID8 YMR141CNDE1 IMP1 RIM13 YMR158C-A AIM36 tv(aac)m3 DNF3 INP2 MSS11 YMR166CALD3 PAH1 CEP3 MLH1 ARS1323 ARS1324 ARS1325 ARS1327 ARS1328 ARS1329ARS1330 ARS ARS1332 DDR48 SIP18 ECM5 YMR178W YMR182W-A YMR185W GCV2 GYL1 RPL36A YMR196W YMR173W-A YMR175W-A HOT1 MMT1 SPT21 ADD37 HSC82 SPG5 MRPL24 ICY1 CIK1 CLN1 ERG2YMR206W YMR210WCEF1 GAS3 ESC1 UBP8 RPS10B PEP5TRI1TAF9 DFG5 YMR242W-A YMR245W YMR247W-A GTO3GFD1 SAP30RSN1 TMA23 YMR272W-B FCP1 GPI12YKU70HSH155 YMR290W-A YMR294W-A GOT1 LIP1 FKS3 ELP6 ROT1 TOM40 ERG12DML1SCJ1 GUA1 ERG8 MTF1 YMR230W-A FUS2 RNH1 BCH1 YHM2 YMR244W FAA4 GAD1 HOR7 YMR262W CUE1PPA2 YMR272W-A DSK2 PGM3 SUP8 MRPL33 ABZ2TDA1 JNM1PRC1 UBP15 GAS M 0.630M 0.660M ALD3EAR1PAI3 YMR181C SSO2 MRPS17 YMR193C-A YMR194C-A RAD14 YMR172C-A ALD2 CTL1 RGM1 YMR187C SGS1 CMC4VTI1 INP1 PFK M 0.720M 0.750M 0.780M YMR209C SKY1 YMR221C MRE11 YMR226CRRP5 tr(ucu)m1 CUS1ZRC1 RKR1 YMR252C YMR254C PET111 TRM732 HFA1 EFR3 TRS130 FSH2 MRPL44 TAF7 RNA1 RNT1 RPL20A YMR244C-A ta(agc)m2ymr253c COX7 ROY1TIF11 TPS M 0.840M 0.870M PRP24 URA10 SCS7RCE1 YMR279C AEP2 NGL2 HAS1 YMR295CDYN3 ATM1ADH2 SCW10 YMR307C-A YMR265C RRN9 CDC65 ZDS1BUL1 CAT8 RIT1 DSS1 HER2 LCB1 ADE4YME2 YMR304C-A YMR306C-A PSE1 YMR310C NIP1 GLC8 TGL M 0.630M 0.660M 0.690M 0.720M 0.750M 0.780M 0.810M 0.840M 0.870M

18 TGL3 PRE5 YMR315W YMR315W-A DIA1 YMR316C-A YMR317W YMR316C-B ADH6 FET4 YMR320W YMR321C SNO4 ERR3 YMR324C PAU19 YMR326C 0.900M 0.900M 0.900M chrxiii_2

19 chrxiv YNL339W-A YNL337W DDI3 THI12 YNL339W-B YNL338W COS1SNZ2 YRF1-6 ARS1405 ARS1406 ARS1407 ARS1411 ARS1412 ARS1413 ARS1414 YNL324W YNL319W VNX1 DAL82 STB1 YPT11TOS6 EGT2 LEM3 YNL320W PFS2 RFA2 MRPS18 YNL303WTRF5 CLA4 YNL295WPUS4PCL1 SEC21 YNL285W tt(agu)n1 HCH1 CAF120 MET2 TOF1 LYP1 YNL266W YNL296WMSB3RFC3 CAF40CUS2 tn(guu)n1pop3 YNL277W-A PRM1 BOR1 BSC4 PIK1 POL2 ORC5 TEX1 YNL247WSLA2 LAP3YTP1 YNL234W CSL4 YNL226WSSU72 MGS1 RAP1 PEX17YNL208W MER1 SPS19 FOL1 RAD50 VPS75 ATG2 KEX2SIN4BNI4YNL228W ATG4ADE12 YNL217W IES2 VID27SSB2 RIO2 YNL193W CHS1 YNL190W KAR1 UBP10 DUG3 SRP1 SWT21 YNL181W 30M 60M 90M 0.120M AAD14 PEX6 PFA3 KRE1 PHA2 EMW1 ZIM17MCK1 RPS19B MON2 MID1 MRPL10ERG24 GOR1 SNO2RPD3 MDJ2 FIG4 HXT14 ATP11 SKP2KRI1BXI1 RPL18B RIM21 SUF6 WSC2 YNL276C SEC2 BNI M IST1 YIF1 ATX1 ALP1 PDR17 YNL260C DSL1 SIP M 0.210M 0.240M 0.270M RTC4NRD1 RPA49SUI1 NAR1 PDR16 URE2 CNM67 POP1 RRG9 RTT106 SPS18 PSY2 GCR2 YNL195C WHI3 GIS2 MRPL17 MPA43CWC25 ZWF1 YNL235C ELA1 JJJ1 SQS1 ALG9 YNL211C YNL205C YNL203C YNL200C YNL198C YNL194C SLZ1 MRPL19 NPR1RHO5 YNL184C IPI3 30M 60M 90M 0.120M 0.150M 0.180M 0.210M 0.240M 0.270M ARS1415 ARS1417 ARS1419 ARS1420 ARS1421 ARS1422 YNL174W YNL170W YNL162W-A CBK1YNL155W PGA1YNL150W YNL144W-A YNL146W AAH1 SRV2 tf(gaa)n TOM22 TEP1SPC98NMA111 MLS1RPC19 YNL109W RPS3 APC1 YNL165WRPL42A YGP1 IGO1 INN1LSM7 MFA2MEP2 YSF3EAF7KRE33NRK1 FAR11 NAF1 NCS2 DMA2DBP2YAF9 RRT16 MET4 YNL097W-A AVT4 YNL092W APP1 RHO2 YNL103W-A POL1 AIM37 tl(caa)n YPT53 NST1 TOP2 TCB2 MKT1 SNN1SAL1 PMS1 APJ1IMP4 RNH201 TOM7 YNL067W-B SUN4MTQ1 YNL057W VAC7 COX5AALG11 tp(ugg)n1 LAP2BOP3 BDP1 NCE103 YNL034W SIW14 YNL028W SAM50 NIS1 MKS1 MSK1 LAT1 YNL067W-A RPL9BAQR1 NOP2OCA2 MSG5 COG5YNL046W YNL042W-B YIP3YNL040W GPI15tP(UGG)N2 YNL033W HHF2 CRZ1 HDA M 0.330M RHO5 MRPL22 NOP13 YNL171C FMP41 BNI5 YNL179CTDA7 MDG1 PSD1 SKO1IBD2 RIA M 0.390M 0.420M 0.450M 0.480M 0.510M 0.540M 0.570M NSG2 YNL146C-A GIM3 PGA2 YNL143CTHO2 FPR1 FYV6 DGR1 YNL122C YNL120CYNL115CYNL108C CYB5 LEU4 RAS2 PHO23 YNL095C END3 EOS1 MLF3 FKH2 GCD10 YNL058C td(guc)n SFB2YNL043C IDH1 YNL035C HHT2 YNL024C SSN8 YNL022C YNL019C ASI2 YCK2 RPC31 ALF1 YNL144C YNL140C NAM9 YNL134C CPT1 ESBP6 TOM70 DCP2YNL114C NOP15 INP52 YNL097C-B OCA1 RPS7B YNL089C SWS2 TPM1 RPL16B YDJ1 ARP5POR1 YNL050CSLM2 COG6 tt(agu)n2 ti(aau)n1 KTR5 KSH1 FAP1 ARK1 YNL018C ARS1424 CEN_chr14 ARS1426 ARS1427 PUB1 ti(aau)n2pbi2 HEF3 YNL010WLST8 tn(guu)n2 DOM34 SWM2 LRO1 CSE2YNR014W TIM23 ARE2 SNF12 BUD17 ALG12 YNR034W-A ABZ1 YNR040W MVD1 PET494 FPK1 BIO3 FRE4 PDR18 COS10 SPO1IDP3 HRB1 YNR001W-A YNR003W-A VPS27NRM1URK1SMM1 RCF2 YNR021W MPP6 CPR8 PPG1 SOL1DBP6 YNR042W AGA1 TRM112 YNR048W MNT4 YNR063W HXT17 PAU M 0.630M 0.660M 0.690M 0.720M YNL018CYNL013C ASI3MRP7RLP7SUF10 RPC34ATG3 PHO91 ATP23 YNR025C YNR029C HUB1MRPS12 ZRG17 MSO1 YNL017C YNL011CSIS1 PET8CIT1 ATO2 YNR005C PRP2 ACC1 MRPL50 SEC12 SSK2 ARC35 RSM19COQ2 LYS9 BRE M 0.780M tl(uaa)n NOG2 BIO5 YNR061C YNR064C YNR066C YNR068C YNR071C AIF1 YNR077C POP2 ESF2 HOL1 BIO4 YNR062C YNR065CDSE4BSC5 YNR073C YNR075C-A 0.600M 0.630M 0.660M 0.690M 0.720M 0.750M 0.780M

20 chrxv_1 ARS ARS1507 ARS1508 ARS1509 ARS ARS ARS1510 ARS ARS1511 YOL164W-A YOL163W YOL160WYOL155W-A YOL166W-AYOL162W BDS1 HXT11 ZPS1 FRE7 DCP1 NOP8 PPM2 BSC6GAS4 ALR1 RPL25 HRP1 MSN1SKM1 tt(agu)o1 YOL107W SHR5 PKH2 TRM10 SPO21 MHF1 PHM7 ATG19 YOL079W ATP19 THP1 NUF2 GPD2 YOL057W tn(guu)o1 AIM39 GSH2 PEX15RPP2A YOL036WMSE1GAS5 LAG2 IFM1 YOL019W-A TAT2 ESC8 YOL014W GRE2PSF3 RRP40 ARG8 YOL131W HRT1 VPS68TRM13 RRI2PAP2MSB4 YOL106W ZEO1 ITR2 YOL097W-A YOL092W MSH2 YOL085W-A ATG34 IRA2 AVO1 MDM20 EMI5 PRS5 ARG1 GPM3PSH1 GAL11 PSK2NGL1PRE6 SMC5 OPI10tS(GCU)O YOL024W SUF17 YOL019W SUP3 IRC10 YOL166C AAD15 30M 60M 90M 0.120M 0.150M 0.180M 0.210M 0.240M 0.270M PAU20 YOL159CIMA2 YOL150C PEX11 RIB4 RTC1 MED7 YGK3TRM11 RPS19A MCH4 YOL114C SUF1 WSC3 TPT1 YOL099CWRS1 HMI1 HAL9DUF1 YOL085C REX4 YOL075CNBA1 RTG1 INP54 CRT10 MAM3tG(GCC)O1 SPE2 YOL046C RRT8 YOL038C-A NOP12 YOL035C YOL029C MDM38 TSR4 YOL159C-AENB1 HPF1 SPT20CTR9 CDC33YOL134C PFK27 MDH2 SMF1 RPL18A YOL118C MDY2 INO4NDJ1 IZH4 YOL098COQ3 RFC4 MPD2ADH1 YOL083C-A BRX1YOL073C HST1 RIB2 MET22 APM4 THI20 DDR2 YOL050C YOL047C NTG2 RPS15 YOL037C SIL1YAP7 MIM1 DIS3 TLG2 CMK2 30M 60M 90M 0.120M 0.150M 0.180M 0.210M 0.240M 0.270M CEN_chr15 ARS1513 ARS ARS1514 ARS1516 YOL013W-B tp(ugg)o1 RCL1 SIN3 RRP6YSP3 YOR008W-B AUS1 YOR012W RTS1 PET127 YOR019WYOR024W BUB3 YOR029W CRS5 PEP12CKB2 CUE5 IRC23 YOR053W SGT1 CKA2CYT1 VPS5 YOR072W-A YOR072W-B YOR073W-A RTS2 DIA2 LPX1 tn(guu)o2tma46 ARF3 KTR1 YOR102W YOR105W RGS2 INP53 YOR111W AZF1 RPT5 GCY1 td(guc)oeft1idh2 LSC1 YOL013W-A YOL014WPLB3 COQ10 PHO80 ALG6 UTP23 TIR4YOR011W-A IRC11 YOR015W ROD1 YOR020W-AHST3 STI1YOR032W-A DFG16 CYC2GLO4 WHI2 TOM6 YOR055W tk(uuu)o RPL3MSA1 YOR072W SUF11 SGO1 UFE1 BUD21 WHI5 OST3 YVC1 ECM3 RPS7A RAS1 PIN2 VAM3 LEU9 TFC7 CEX1 YOR114W RTC5 RGA1 VPS17 BAG7 SFL M HRD1MDM12 HTZ1 CSI2 TOP M 0.360M 0.390M 0.420M 0.450M PFA4 DNL4 SGT2 SLG1TIR2 ERP4 SFM1 AHC1 HMS1AKR2 SHE4 YOR041C STD1 RSB1 ETT1 VHS3 ASE1 SLD7YNG1 VAM10 RPB11 IZH2 tr(acg)o YOR008C-A TSR3 tt(agu)o2 HSP10 YOR022C CIN5 YOR034C-A EXO1 HIR2 DBP5 RAT1 YOR050C YOR052C NOB1YOR059C YOR062C ALG8GYP1 NRT M 0.510M 0.540M SKI7 TGL5 TCB1 PTC5 RKI1 NUP1 OST2 TRS33 RIO1 PFY1 CDC21 ATX2 YOR082C VPS21 YOR093C YOR097CCRC1YOR108C-A RPO31 YOR121C LEO1 UBP M IAH1 AFI1 YOR131C SIA1 YOR139C SUF5 CAT5ADE2 ORT1 IRC14 RUP1ARP8 ARS1517 ARS1519 ARS1521 ARS1523 ARS1524 ARS1526 MDM32 PDR5 PET123 YOR161W-A DDP1 GLN4YRM1 MED4 LAS17 SER1TUF1IES4 YOR146W MRPL23 SLP1 YOR161W-B MTR10 SEY1 YOR170WDCS2 HEM15 FYV12 YOR186W MSB1 SPR1 ULS1 PEX27 YOR200W MCA1 YOR203WNOC2 RPB10 RFC1 YOR225W ODC2 WTM2 MKK1 KIN4 YOR238W DFR1 MET7 SRL1TMA16 OSW1 HNT3 YOR262W RBL2 PAC1 MOD5 HEM4 YOR283W RDL1 YOR289W RPS10A UAF30 MUM3 YOR300W YOR302W ISW2 IMT1 SLK19 YOR199W HIS3 DED1 PTP2 STE4 RCN2 YOR223W HER1 WTM1 MGE1 IRC13 HES1 ABP140 ESA1 YOR248WNAT5CDC31 GCD1 DSE3 PNT1 YTM1 CAF20 YOR282W HUA2 RDL2 YPK9YOR296W RRS1 BUD7 RAX1 CPA1RRG M 0.630M 0.660M 0.690M 0.720M 0.750M 0.780M 0.810M 0.840M 0.870M THI80PNO1SMP3 YOR152C NFI1YOR161C-C SME1 GET4 RPS28A LCB4 tv(aac)ogac1dci1 GSP2 THI72 TOA1 BFR1 GEP3 NPT1 SAS5 AIM41 YOR218CMCT1 ISU2 YOR231C-A SSP2DGA1APC5 TUM1TRE2 RPN8 HRK1VPH1 TPO4 YOR277C FSH3 ta(ugc)o RRP36 YOR292C TIM18 YOR304C-A SLY41 YOR309C DGK1 ELG1SPP2 RPB2 ISN1PUP1 PNS1 YRR1 SWT1 YOR169C ALE1MPC54SYC1 RPS30B YOR186C-A YOR192C-C LIP5 MRM1 RET1 MGM1 YOR214C RUD3 STE13 RPB8 YOR228C RPL33B PUS7ENV9CLP1 SEC63 RPT4 YOR263C YOR268CFSF1 RIM20 RFM1 PLP2 MPD1 SNF2 YOR293C-A MBF1 MCH5 SNU66 NOP M 0.630M 0.660M 0.690M 0.720M 0.750M 0.780M 0.810M 0.840M 0.870M

21 chrxv_2 ARS1528 ARS1529 ARS YOR314W-AFAA1 PMT3 MYO2YOR329W-AMRS2 KRE5 YOR338W YOR314W SFG1 HSH49 YOR325W PDR10 YOR335W-A VMA4 TEA1 RPA190 EMT2 REV1 tp(ugg)o3 TFB6 CIN1 CIR2VTS1 GDS1HAP5 YOR366W RAD17 YOR364W SCP1 YOR376W-A ALD4 YOR378W NUD1 YOR376W ATF1RDR1 FIT2 YOR385WYOR389W YOR392W PAU21 YOR381W-A FRE5PHR1 YOR390W ERR1YRF M 0.930M 0.960M 0.990M 1.020M 1.050M 1.080M RPL20B COT1 YOR318CLDB19 FRT1 SCD5 YOR331C ALA1 RPA43YOR343C YOR345CPUT4 MEK1 MSC6 PDE2 PRE10 YOR365CMRS6NDD1 YOR379C YOR387C HSP33YOR396C-A YOR316C-A SPS4 GNT1 PRO2 SNC2 YOR333C MIP1 UBC11YOR342C TYE7 PYK2 MNE1SOG2 SNX3 PRT1 PIP2 RPS12GPB1 GDH1 FIT3 FDH1YOR394C-A 0.900M 0.930M 0.960M 0.990M 1.020M 1.050M 1.080M

22 chrxvi_1 ARS1601 ARS1602 ARS1604 ARS1605 ARS1607 ARS1609 ARS1614 YPL283W-A SAM3ATP15 KAR9ACM1 DIP5YPL260W BBP1 YPL251W YPL245W YAR1 RVB2 SSO1 USV1 CET1 YPL225W FLC1 PCL8YPL216WLEA1 RKM1HRR25 CSM4 OXR1 YPL283W-B HSP32 SAM4MDL2PLC1 DIM1 FUM1 YPL257WYPL250W-A HFI1 SRP68 SUI3 NSL1 FAS2 YPL229WNEW1FMP40 RPL1A SAR1 CBP3 NIP7 TYW1TPK2 RPL7B APL5 DDC1 MF(ALPHA)1 GUP2 RTC6 TCO89CBC2 MRPL40 YPL168W CDC60 YPL152W-A YPL150WPXA1RPL33A ISU1 RSA1 YPL185W POS5 CTI6PPQ1 SPT14 DAP1 ATG29 TGS1 RRD2 ATG5 POC4 YPL136W 30M 60M 90M YRF1-7 ERR2 YPL278C YPL272C KEL3 tw(cca)p APM1 VIK1 ICY2 GYP5 YPL247C HUT1 PAU22 YPL279C YPL277C YPL264C YPL261C THI21 CLN2 RPL36B YAH1 GAL4 RBD2 IQG1 CIN M 0.150M 0.180M 0.210M YPL238C VMA11 YPL222C-A MMT2 THI6SRP72 PGC1AFT2 YPL199C PRM3 NAB3 UIP4RTT10tE(UUC)P HSP82ENV7 ALG5 GRE1 BMS1 PUS1IPL1YPL205C YIG1 YPL197CYPL191COA2 MRN1 YPL182C CUP9 TRE M 0.270M COX10 MEX67 SET6 SVS1 BEM4 AIM44KIP2RAD53 PPT2 KES1 FRK1UME1 GIP3ODC1 NIP100OYE3 REV3YPL162C MLH3 PET20PRM4 PEP4 PRP46 NOP53 YPL142C MKK2 YPL135C-A SPP1 RDS2 30M 60M 90M 0.120M 0.150M 0.180M 0.210M 0.240M 0.270M ARS1618 ARS ARS1619 ARS ARS1621 CEN_chr16 ARS RPL5 TAF14 KAP120 VPS30 HOS3 CAR1YPL107W ELP4MSY1NOG1 GLR1 YDC1 COX11 SPO19 NAN1 SPC29 MRP51YPL114W YPL108W MSD1 ATG21PNG1 SSU1YPL088WSEC16 BRO1 RPL21B RPS9AGPI2 GCR1 UBP16 RGL1 TIM50 ALD6 GRX5 OAZ1CAM1 VPS16 YPL039W MET31 YPL034W SUV3 SMA1 RAD1 CTF19 YPL014W RET3 NCR1ULA1CIT3 tg(gcc)p1sut2 YPR012W RLF2 ATP20 YTA6MUK1VPS28 YPL062W MFM1 LEE1ARL3SGF11NOP4 YPL038W-A PMA2 TRM44 ERG10RMI1 ECM23 SWI1 RRP12 CHL1 AEP3 HAT1 PDH1 HAA1 tk(cuu)pypr016w-a MCM M 0.330M RDS2 HHO1 YPL119C-A TFB2 IDI1 YPL113C IMT2 YPL109C TBF1 RNY1 MEI5DBP1 BEM3 PEX25GDE1 SSE1 SYH M 0.390M YPL102C MGR2 EEB1 RPS6A ELP3 FMP30 AIM43 ERI1 SEC62 RLM1 SEN54 MOT M 0.450M ATP4 YPL073C YPL067C BTS1 tc(gca)p1 YPL080C YPL077C YPL071C YPL068C CWC27 PDR12 SUR1 LGE1 MNN9ELC1 LCL1KTR6DIG1 YPL044C YPL041C SSN M 0.510M 0.540M 0.570M ISM1 YPL035C SVL3 SKS1 MET12 VTC3 HST2 TAF3 TFC8 SNF8 YPR002C-A AIM45 ICL2 RPA135 YPR011C YPR014CTIF6 EGD1SRL4 PHO85 YPL025C ULP1IRC15 MRPS16 TAE2 LSP1 tf(gaa)p1 YPR003C HAL1 REC8 YPR010C-A YPR013C YPR015C DSS4 ATP20 ARS1623 ARS1624ARS1625 ARS1626 ARS ARS1627 ARS1628 ARS1630 YME1 YOP1 ATH1 CSR2 NTO1 ARP7 VMA13 IRC16 TIP41RPL43A MSF1 MAK3 SEC8 BRR1FCY1 ROX1 ISA2 YPR071W NOT5 YPR076W TEF1 YPR084W VPS69 YPR092WYPR097W SNT309 YPR108W-A ISR1 YPR109W PIS1 SRO7 YPR036W-A GLN1 YPR039W TIF5 MCM16 TAH18 SMK1TFB4 YMC1 YPR064W UBA3MED1 SUP16 YPR074W-A MRL1MDM36 SUA7 YPR089WRDS3 MRPL51 PRE2 tt(ugu)p RPN7 DBF20 YPR114W RGC1 YPR117W CLB2 RRG8 MRI1 THI22 AXL1 YLH47SCD6 TOM5 CTF4tN(GUU)P RRP15ASN1 YPR150W PIN3 CUR1 KRE6 GPH1 MMS1 YPR169W-A YPR170W-A NUT2 YPR172WPRP4 CTR1 YPR127W RPS23B MSS18RRP9 ti(aau)p1 TAZ1 NCE102 YPR153W TDA6 ta(agc)p tg(gcc)p2 YPR160W-A RHO1 YPR170W-B JIP5 BSP1DPB2 AOS M AGC1 YPR022C EAF M 0.660M 0.690M 0.720M YPR027CAPL4 ERV2 OPI11 ATG11 NHP6AYPR059C JID1 HOS1 LTP1 YPR078C OPY2 DIB1 SRP54 CCL1 tf(gaa)p2 HTS1 PUF2 THP3YPR050C YPR053C YPR063C ARO7 SPE3 YPR077C TKL1 GRS2 ASA1 NVJ2 ASR M 0.780M 0.810M 0.840M 0.870M YPR096C YPR099CFHL1 YTH1 MRD1 CLB5 YPR123CANT1 NAT3YPR136C LOA1 YPR142C YPR145C-A YPR147CSUE1NCA2 YPR159C-ASGV1 TIF3 MET16 YPR170C YPR174C YPR177CSEC23 SYT1 YPR098C RPL11A COG4 RPC40 tk(uuu)p tc(gca)p2 YPR126C YPR130C SPN1 MEP3KAR3 NOC4 YPR146C YPR148CURN1TPO3 YPR160C-AORC4 ti(aau)p2 MRP2 VPS4BET2 HDA M 0.630M 0.660M 0.690M 0.720M 0.750M 0.780M 0.810M 0.840M 0.870M

23 chrxvi_2 ARS1631 DPM1ATG13 SKI3 AQY1 SGE1 YPR202W YPR204W SMX3 GDB1RPO26 QCR2 YPR196W YPR203W ARR M 0.930M PZF1 RPC82 OPT2YPR197CARR2 MLC2 HPA2 YPR195C ARR1 YPR204C-A 0.900M 0.930M

24 chr2micron RAF1 FLP1 REP1 REP2