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1 / Taiwan Institute of Economic Research α MinoxidilFinasteride Minoxidil 25 Minoxidil Finasteride 5α5α 5α Taiwan Institute of Economic Research 3 Taiwan Institute of Economic Research 4

2 ~ (PRP)2,000~12,000 Taiwan Institute of Economic Research 5 Taiwan Institute of Economic Research 6 (American Hair Loss Association) ,1004,000 2,100 IBISWORLD Industry Report (2015) 32.9%38.6% 7% Propecia 27.5 % Rogain Foam 14.8 % Minoxidil 13.4 % Proscar () 4.3 % Nizoral Shampoo 6.1 % / Other herbs / vitamins 3.2 % Home Low level laser therapy 3.7 % Other special shampoos 5.5 % Head and Shoulders 2.7 % Biotin 4.9 % Minoxidil Compounded Minoxidil w/ additives 3.8 % Clinical low level laser therapy 1.4 % Avodart 1 % Taiwan Institute of Economic Research 7 Nioxin Shampoo 1 % Relevant Research(2014) Taiwan Institute of Economic Research 8

3 ISHRS(2015) , %15.3% AVEDA70% AVEDALUSH JAK (Science Advances) () (ips) (2012) PRP() 3 Taiwan Institute of Economic Research 9 Taiwan Institute of Economic Research 10 (2016) ~ % (CAGR) (2016) ~ % IBISWORLD Industry Report (2015) Taiwan Institute of Economic Research 11 (2012)HistoGen(2009)Relevant Research(2014) Taiwan Institute of Economic Research 12

4 Minoxidil Minoxidil - Procapil-(Apigenin) (Oleanolic acid) () Taiwan Institute of Economic Research 13 / 1 Rogaine Minoxidil 2,000/60ml ml /400 ml 5 ( 5ml) 379/400 ml 5 ( ( ) 5ml) 2 Minoxidil 1,300/60 ml ml /300ml 13 1~2 5 ml () 3 Minoxidil 900/60ml /320ml Diphenhydramine HCl 0.01% Estradiol 0.001%360/320ml Minoxidil 1680/60ml ml Minoxidil 1200/90ml 27 1ml /420ml 4 EQ10 350/420ml Taiwan Institute of Economic Research 15 Taiwan Institute of Economic Research 14 / /50ml 20 S.G.S /360ml /50 g /250ml 9 ( 5ml) S.G.S. 3~ ~ (0.5-1g) 3 (SGS 21~2 - (Minoxidil)312 ) /32ml 28 ( 2~5 5ml) 2 9 SLL SLL B /120ml ( 2ml) /50ml 17 - ( Original 60 2ml) Bioscalin 500/150ml 7 PEG-35 ( 2ml) 490/150ml 16 (, 5ml),, 11 Swissvita Capixy TM ( Procapil /100ml 2ml) CapixyTM /250ml 12 (,, 5ml), Taiwan Institute of Economic Research

/ 12 2300/150ml 31 ( AVEDA 2ml) 3600 18 ( /1000ml 5ml) 13 KERAST SP94 680/250ml 14 ( ASE 5ml) 19912015822007 14

9 (IT) 7 (CN) 6 28 Aster or Sunflower family 7 angiosperms 6 dicotyledons 5 Mint family 5 Pea or Legume family 4

5 / /150ml 31 ( AVEDA 2ml) ( /1000ml 5ml) 13 KERAST SP94 680/250ml 14 ( ASE 5ml) ~ Taiwan Institute of Economic Research 17 Taiwan Institute of Economic Research 18 (JP) 18 (KR) 14 (US) 9 (IT) 7 (CN) 6 28 Aster or Sunflower family 7 angiosperms 6 dicotyledons 5 Mint family 5 Pea or Legume family 4 ginseng 3 Tea family 3 Palm family 3 3 Taiwan Institute of Economic Research 19 Taiwan Institute of Economic Research 20

6 (JP) (KR) (CN) (IT) (US) (DE) Aster or Sunflower family 6 angiosperms Mint family dicotyledons Pea or Legume family Grass family ginseng 2 Tea family 2 3 Taiwan Institute of Economic Research 21 1 WO Composition for hair loss prevention or hair growth stimulation comprising artemisia umbelliformis extract 2 WO Composition for hair loss prevention or hair growth stimulation comprising scutellaria alpina extract 3 WO Novel formulation of concentrated natural actives in oil-water microemulsion for hair fall prevention and increase in hair density Amorepacific Corporation Amorepacific Corporation Brillare Science Pvt Ltd. 4 WO External skin preparation composition Doori Cosmetic containing herbal medicine extract, for Co., Ltd. preventing hair loss and promoting hair growth 5 WO Hair loss prevention and restoration solution Kirakosyan, Ruzanna 6 WO Compositions based on plant extracts for inhibition of the 5-alpha reductase 7 WO Formulation for treatment of hairs Osma Cosmetics & Laboratories Ag 8 WO Formulation for treatment of hairs Osma Cosmetics & Laboratories Ag (KR) (KR) skullcap (IN) (KR) Amaranth family rockwort Tea family (US) Mint family Myrtle family Bionap S.R.L. (IT) Grass family Cactus family (CH) Tea family Palm family Olive family (CH) Tea family Palm family Olive family 9 WO Use of a vegetal extract for the prevention and Giuliani S.P.A. (IT) dicotyledons treatment of hair loss 10 WO A composition comprising an extract of Sam Chun Dang (KR) combined herbs consisting of acanthopanax Pharm. Co., Ltd. monocotyledons koreanum nakai and crinum asiaticum var. Japonicum showing preventing activity of baldness and stimulating activity of hair growth Taiwan Institute of Economic Research Minoxidil Minoxidil Taiwan Institute of Economic Research 23 Taiwan Institute of Economic Research 24

7 Minoxidil AVEDANisarga(GGF) TEL: (02) FAX: (02) Taiwan Institute of Economic Research 25 Taiwan Institute of Economic Research

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