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1 ( ; ) [ ] OLP OLP [ ] [ ] R [ ] A [doi] /j.issn Research progress on the role of autophagy in the malignant transformation of oral lichen planus Chang Zhen 1, Li Ronglin 1, Li Chunyang Dept. of Conservative Dentistry and Endodontics, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou , China; 2. Dept. of Stomatology, The Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai , China [Abstract] Oral lichen planus OLP is a common inflammatory disease of oral mucosa, which is easy to recurrent and has malignant tendency. The precise etiology and pathogenesis about OLP is unknown. Autophagy is a highly conserved phenomenon in eukaryotic cells, as one type of programmed cell death, which plays an important role in the maintenance of inter-cellular environment homeostasis. At present, there is no report about the relationship between autophagy and the development and malignant transformation of OLP. In this article, the correlation between autophagy and OLP has been discussed. [Key words] oral lichen planus malignant transformation programmed cell death autophagy 1 [1] oral lichen planus OLP [5] T 90% T [3] OLP chaperone-mediated autophagy CMA [5-6] [4] OLP [ ] [ ] [ ] 2007B [ ] 1985 [ ] Tel

2 Atg12-Atg5 MAP1LC3 Atg12 Atg7 E1 2 Atg10 E2 Atg5 atg MAP1LC3 Atg4B Atg7 Atg3 Atg12-Atg5 Atg16L phosphatidyle thanolamine PE mammalian target of rapamycin mtor / Beclin1 hvps34 UVRAG Rubicon -3- phosphatidylinositol-3-kinase-related kinase PIKK Beclin1 hvps34 UVRAG [10] mtorc1 mtorc2 Beclin1 hvps34 [7] mtorc1 2.3 ULK1 Atg13 FIP200 mtor Atg12-Atg5 Rab9 mtorc1 ULK1 Beclin1 mtor ULK1 hvps34 Atg5 [8] Atg13 FIP200 Atg7 ULK mtor Atg1 Atg13 Atg17 hypoxia-inducible factor HIF Class -3- phosphoinositide-3-kinase transcription factor FoxO -1 Atg7 PI3K Beclin1 hvps34 Atg14L mtor hvps34 FoxO-1 phosphatidylinositol-3-phosphate PtdIns3P 3 OLP 1 vacuole membrane protein 1 VMP1 Beclin1 OLP [11-12] 88 myeloid differentiation factor 88 MyD88 Bcl-2 DNA Beclin1 hvps34 Atg14L Beclin1 hvps34 Atg14L 1 -κb nuclear transcription factorκb NF-κB p53 Zhao [11] forkhead box O PtdIns3P [9] [13] 1997 Atg OLP OLP [4] Atg12-Atg5 Atg16L Lodi [14] OLP 3 microtubule -associated protein 1 light chain 0%~5.3% OLP 3 MAP1LC3 1%

3 [15-16] OLP interleukin IL -2 interferon IFN - γ matrix metalloproteinases MMP [17] 3.2 OLP p NF-κB NF-κB [21] p53 Copetti [22] p53 Beclin1 NF-κB damage regulate autophagy modulator DRAM p53 TP53-induced glycolysis and apotosis regulator TIGAR TIGAR reactive OLP NF-κB oxygen species ROS NF-κB DRAM NF-κB DRAM T NF-κB p53 Rhodus [3] [18] DRAM NF -κb TNF -α IL -1 IL -8 tumor IL-6 OLP necrosis factor TNF -α T T helper cell Th 1/Th2 C cytochrome C cytc Th2 OLP Th1 OLP Th1/Th2 OLP NF-κB OLP [19] NF-κB Inbal [20] OLP NF-κB death-associated protein kinase HIF-1 HIF-1 DAPk DAPk DAPk-related protein kinase DRP -1 Bellot [25] HIF-1 B 2/ 3 Bcl-2/adenovirus E1B 19-kDa [16] CD4 + T NF-κB p65/rela Atg6 Beclin1 Santoro [23] [24] interacting protein 3 BNIP3 B 2/ 3 Bcl -2/adenovirus EIB CD8 + T 3 19-kDa-interacting protein 3-like BNIP3L 1 CD8 + T BNIP3 BNIP3L Bcl-2 TNF-α TNF-α Beclin1 2 CD8 + T HIF-1 Beclin1 [26] CD95L Atg5 CD95 3 CD8 + T HIF-1 Beclin1 Ding B [27] OLP

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