Supplementary Data. Department of Biochemistry and Molecular Biology, Department of Chemistry, and Michael Smith
|
|
- Μέδουσα Βασιλικός
- 5 χρόνια πριν
- Προβολές:
Transcript
1 Supplementary Data ph-dependent random coil 1 H, 13 C, and 15 N chemical shifts of the ionizable amino acids: a guide for protein pk a measurements Gerald Platzer #, Mark Okon 2, and Lawrence P. McIntosh * Department of Biochemistry and Molecular Biology, Department of Chemistry, and Michael Smith Laboratories, University of British Columbia, Vancouver BC, V6T 1Z3, Canada # Present address: Department of Structural and Computational Biology, Max F. Perutz Laboratories, University of Vienna, Vienna Biocenter Campus 5, A-1030 Vienna, Austria *Corresponding author: Lawrence P. McIntosh Department of Biochemistry and Molecular Biology Life Sciences Centre, 2350 Health Sciences Mall University of British Columbia Vancouver, B.C. Canada, V6T 1Z3 Phone: (001) mcintosh@chem.ubc.ca 1
2 Table S1 ph-dependent chemical shifts (ppm) of the ionizable amino acids in blocked Ac-Gly-X-Gly-NH 2 tripeptides a Δ calc. N-terminal amine: Alanine- (pk a 8.23) Ala 1 H H (amine) 8.04 Hα Hβ (methyl) C Cα Cβ (methyl) CO N N (amine) H H 2 N (Z) 7.24 H 2 N (E) N N C-terminal carboxylic acid: N- alanine (pk a 3.55) 1 H CH 3 (methyl) C CH 3 (methyl) CO Ala 1 H HN Hα Hβ (methyl) C Cα Cβ (methyl) CO N N
3 Δ calc. Aspartic acid: Ac-Gly-Asp-Gly-NH 2 (pk a 3.86) 1 H CH 3 (methyl) C CH 3 (methyl) CO H HN Hα (avg.) C Cα CO N N Asp 1 H HN Hα Hβ (avg.) H2 (carboxyl) > C Cα Cβ Cγ (carboxyl) CO N N Gly(+1) 1 H HN Hα (avg.) C Cα CO N N H H 2 N (Z) H 2 N (E) N N
4 Δ calc. Glutamic acid: Ac-Gly-Glu-Gly-NH 2 (pk a 4.34) 1 H CH 3 (methyl) C CH 3 (methyl) CO H HN Hα (avg.) C Cα CO N N Glu 1 H HN Hα Hβ (avg.) Hγ Hε2 (carboxyl) > C Cα Cβ Cγ C (carboxyl) CO N N Gly(+1) 1 H HN Hα (avg.) C Cα 44.9 CO N N H H 2 N (Z) H 2 N (E) N N
5 Δ calc. Histidine: Ac-Gly-His-Gly-NH 2 (pk a 6.45) c 1 H CH 3 (methyl) C CH 3 (methyl) CO H HN Hα (avg.) C Cα CO N N b His c 1 H HN 8.55 ~8.35 d ~ Hα ~ 4.75 d 4.59 ~ Hβ (avg.) H Hε H1 >10 Hε2 >10 13 C Cα Cβ Cγ C Cε CO N N b N b Nε b Gly(+1) 1 H HN 8.55 Hα (avg.) C Cα CO N N b H H 2 N (Z) H 2 N (E) N N
6 Δ calc. Cysteine: Ac-Gly-Cys-Gly-NH 2 (pk a 8.49) 1 H CH 3 (methyl) C CH 3 (methyl) C CO H HN 8.32 Hα (avg.) C Cα CO N N b Cys 1 H HN 8.48 Hα Hβ (avg.) Hγ (thiol) ~ 2.0 e 13 C Cα Cβ CO N N b Gly(+1) 1 H HN 8.58 Hα (avg.) C Cα CO N N b H H 2 N (Z) H 2 N (E) N N
7 Δ calc. Tyrosine: Ac-Gly-Tyr-Gly-NH 2 (pk a 9.76) 1 H CH 3 (methyl) C CH 3 (methyl) CO H HN 8.21 Hα (avg.) C Cα CO N N b Tyr 1 H HN 8.16 Hα Hβ (avg.) H Hε Hη (phenol) ~ 9.3 e 13 C Cα Cβ Cγ C Cε Cζ CO N N b Gly(+1) 1 H HN 8.44 Hα (avg.) C Cα CO 15 N N H H 2 N (Z) 7.07 H 2 N (E) N N
8 Δ calc. Lysine: Ac-Gly-Lys-Gly-NH 2 (pk a 10.34) 1 H CH 3 (methyl) C CH 3 (methyl) CO H HN 8.31 Hα (avg.) C Cα CO N N b Lys 1 H HN 8.40 Hα Hβ (avg.) Hγ H Hε Hζ (amine) 7.52 ~ 1-2 f ~ - 6 f C Cα Cβ Cγ C Cε CO N N b Nζ (amine) 32.7 ~ 25.2 g ~ g H HN 8.50 Hα (avg.) C Cα CO N N b H H 2 N (Z) 7.07 H 2 N (E) N N
9 Δ calc. Arginine: Ac-Gly-Arg-Gly-NH 2 (pk a ~ 13.9) 1 H CH 3 (methyl) C CH 3 (methyl) CO H HN Hα (avg.) C Cα CO N N Arg 1 H HN Hα Hβ (avg.) Hγ H 3.21 ~ 3.04 ~ Hε (guan.) Hη (guan.) C Cα Cβ Cγ C Cζ (guan.) ~ ~ CO N N Nε (guan.) Nη (guan.) ~ 71 h ~ 71 h 1 H HN Hα (avg.) C Cα CO N N H H 2 N (Z) H 2 N (E) N N
10 a Recorded at 25 o C with 50 mm NaCl and 5% D 2 O, unless indicated. Reported are the fit pk a values and end point chemical shifts (ppm) of the of the acid and conjugate base forms, along with the chemical shift change upon deprotonation (Δ; negative is upfield) and the predicted shift at ph 7. The estimated errors are ± 0.05 for pk a values (± 0.1 for arginine), ± 0.02 ppm for 1 H nuclei, ± 0.08 ppm for 13 C, and ± 0.06 ppm for 15 N. Blank values indicate not determined. Prochiral proton shifts are averaged. The C-terminal protons are assigned assuming Z/E as upfield/downfield. b Recorded in 99% D 2 O and corrected for the deuterium isotope shift. c Data for neutral histidine is an average of ~80% N ε2 H and ~20% N 1 H tautomers. d Estimated from (Kjaergaard et al. 2011). e From the BioMagResBank (Ulrich et al. 2008). f From (Takayama et al. 2008). g From (Andre et al. 2007). h From 13 C 6 / 15 N 4 -L-arginine (Table S2). 10
11 Table S2 ph-dependent chemical shifts (ppm) of 13 C 6 / 15 N 4 -L-arginine a,b (HAH) ph ~ 7 ph ~ 11.5 ph > 15 Δ due to amine (HA - HAH) Δ due to guan. α-cooα-nh 3 + guan+ α-cooα-nh 2 guan+ α-cooα-nh 2 guan 1 H HN (amine) 7.81 Hα Hβ (avg.) < Hγ < H Hε 7.22 Hη C Cα Cβ Cγ C Cζ CO N N (amine) Nε Nη a Recorded at 25 o C for 100 mm 13 C 6 / 15 N 4 -L-arginine with 5% D 2 O, 1 mm DSS, and initially 50 mm NaCl (final KOH > 10 M). Blank values indicate not determined due to rapid HX or spectral overlap. The 1 H β shifts are averaged. Due to bond rotations, the two 15 N η and four 1 H η yield broad signals. The data for neutral arginine are tautomer averaged. b Tabulated are the fit chemical shifts for the two-step sequential titration from ph 7 to of the α-aminium (pk a 9.15 ± 0.05) and then the guanidinium (pk a 13.9 ± 0.1) moieties in the context of the α-carboxylate anion. The estimated fitting errors are ± 0.05 ppm for 1 H nuclei, ± 0.1 ppm for 13 C, ± 0.15 ppm for 15 N amine and 15 N ε, and ± 0.3 ppm for 15 N η. 11
12 Supplemental References Andre I, Linse S, Mulder FAA (2007) Residue-specific pk(a) determination of lysine and arginine side chains by indirect 15 N and 13 C NMR spectroscopy: Application to apo calmodulin. J Am Chem Soc 129: Kjaergaard M, Brander S, Poulsen FM (2011) Random coil chemical shift for intrinsically disordered proteins: effects of temperature and ph. J Biomol NMR 49: Takayama Y, Castaneda CA, Chimenti M, Garcia-Moreno B, Iwahara J (2008) Direct evidence for deprotonation of a lysine side chain buried in the hydrophobic core of a protein. J Am Chem Soc 130: Ulrich EL, Akutsu H, Doreleijers JF, Harano Y, Ioannidis YE, Lin J, Livny M. Mading S, Maziuk D, Miller Z, Nakatani E, Schulte CF. Tolmie DE, Wenger RK, Yao HY, Markley JL (2008) BioMagResBank. Nucleic Acids Res 36:D402-D408 12
Molecular Tweezers with Varying Anions - A Comparative Study
Molecular Tweezers with Varying Anions - A Comparative Study SomDutt a, ConstanzeWilch a, Thomas Gersthagen a, Peter Talbiersky a, Kenny Bravo- Rodriguez b, MattiHanni c, Elsa Sánchez-García* b,christian
Διαβάστε περισσότεραSupporting Information. Partial thioamide scan on the lipopeptaibiotic trichogin GA IV. Effects on
Supporting Information for Partial thioamide scan on the lipopeptaibiotic trichogin GA IV. Effects on folding and bioactivity Marta De Zotti 1, Barbara Biondi 1, Cristina Peggion 1, Matteo De Poli 1, Haleh
Διαβάστε περισσότεραElectronic Supplementary Information
Electronic Supplementary Information NbCl 3 -catalyzed [2+2+2] intermolecular cycloaddition of alkynes and alkenes to 1,3-cyclohexadiene derivatives Yasushi Obora,* Keisuke Takeshita and Yasutaka Ishii*
Διαβάστε περισσότεραLyotropic Liquid Crystals in Amino acid derived Protic Ionic Liquids: Physicochemical Properties and Behaviour as Amphiphile Self-Assembly Media
Lyotropic Liquid Crystals in Amino acid derived Protic Ionic Liquids: Physicochemical Properties and Behaviour as Amphiphile Self-Assembly Media Jiayi Wang, [a,b] Tamar L. Greaves, [b] Danielle F. Kennedy,
Διαβάστε περισσότεραThe effect of curcumin on the stability of Aβ. dimers
The effect of curcumin on the stability of Aβ dimers Li Na Zhao, See-Wing Chiu, Jérôme Benoit, Lock Yue Chew,, and Yuguang Mu, School of Physical and Mathematical Sciences, Nanyang Technological University,
Διαβάστε περισσότεραSynthesis, structural studies and stability of the model, cysteine containing DNA-protein cross-links
Electronic Supplementary Material (ESI) for New Journal of Chemistry. This journal is The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2017 ELECTRONIC SUPPLEMENTARY INFORMATION
Διαβάστε περισσότεραImproved Peptide and Protein Torsional Energetics with the OPLS-AA Force Field
Improved Peptide and Protein Torsional Energetics with the OPLS-AA Force Field Supplementary Information Michael J. Robertson, Julian Tirado-Rives, and William L. Jorgensen* Department of Chemistry, Yale
Διαβάστε περισσότεραMalgorzata Korycka-Machala, Marcin Nowosielski, Aneta Kuron, Sebastian Rykowski, Agnieszka Olejniczak, Marcin Hoffmann and Jaroslaw Dziadek
Molecules 2017, 21, 154; doi:10.3390/molecules22010154 Supplementary Materials: Naphthalimides Selectively Inhibit the Activity of Bacterial, Replicative DNA Ligases and Display Bactericidal Effect against
Διαβάστε περισσότεραCopper-catalyzed formal O-H insertion reaction of α-diazo-1,3-dicarb- onyl compounds to carboxylic acids with the assistance of isocyanide
Electronic Supplementary Material (ESI) for ChemComm. This journal is The Royal Society of Chemistry 2014 Copper-catalyzed formal O-H insertion reaction of α-diazo-1,3-dicarb- onyl compounds to carboxylic
Διαβάστε περισσότεραCollege of Life Science, Dalian Nationalities University, Dalian , PR China.
Electronic Supplementary Material (ESI) for New Journal of Chemistry. This journal is The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2018 Postsynthetic modification
Διαβάστε περισσότεραSupplementary Information
9.4 6.60. 8.6 8.8 9.29 20.04 29.6 0.07 6. 40.92 4.64 06.0 6.29 6.0-0.00 Supplementary Information Conformational Analysis, Experimental and GIA-DFT C NMR Chemical Shift Calculation on 2 -Hydroxy-,4,-trimethoxy-chalcone
Διαβάστε περισσότεραSUPPORTING INFORMATION
SUPPRTING INFRMATIN Per(-guanidino--deoxy)cyclodextrins: Synthesis, characterisation and binding behaviour toward selected small molecules and DNA. Nikolaos Mourtzis, a Kyriaki Eliadou, a Chrysie Aggelidou,
Διαβάστε περισσότεραAvailable online at shd.org.rs/jscs/
J. Serb. Chem. Soc. 78 (12) S131 S136 (2013) Supplementary material SUPPLEMENTARY MATERIAL TO New 9-aminoacridine derivatives as inhibitors of botulinum neurotoxins and P. falciparum malaria MIKLOŠ TOT
Διαβάστε περισσότεραLewis Acid Catalyzed Propargylation of Arenes with O-Propargyl Trichloroacetimidate: Synthesis of 1,3-Diarylpropynes
Supporting Information for Lewis Acid Catalyzed Propargylation of Arenes with O-Propargyl Trichloroacetimidate: Synthesis of 1,3-Diarylpropynes Changkun Li and Jianbo Wang* Beijing National Laboratory
Διαβάστε περισσότεραSynthesis of α-deoxymono and -Difluorohexopyranosyl. 1-Phosphates and Kinetic Evaluation with Thymidylyl- and. Guanidylyltransferases
Synthesis of α-deoxymono and -Difluorohexopyranosyl 1-Phosphates and Kinetic Evaluation with Thymidylyl- and Guanidylyltransferases Jian-She Zhu, a Nicole E. McCormick, a Shannon C. Timmons, b,c David
Διαβάστε περισσότεραPatrycja Miszczyk, Dorota Wieczorek, Joanna Gałęzowska, Błażej Dziuk, Joanna Wietrzyk and Ewa Chmielewska. 1. Spectroscopic Data.
; doi:10.3390/molecules22020254 S1 of S23 Supplementary Materials: Reaction of 3-Amino-1,2,4-Triazole with Diethyl Phosphite and Triethyl Orthoformate: Acid-Base Properties and Antiosteoporotic Activities
Διαβάστε περισσότεραElectronic Supplementary Information
Electronic Supplementary Information The preferred all-gauche conformations in 3-fluoro-1,2-propanediol Laize A. F. Andrade, a Josué M. Silla, a Claudimar J. Duarte, b Roberto Rittner, b Matheus P. Freitas*,a
Διαβάστε περισσότεραHeterobimetallic Pd-Sn Catalysis: Michael Addition. Reaction with C-, N-, O-, S- Nucleophiles and In-situ. Diagnostics
Supporting Information (SI) Heterobimetallic Pd-Sn Catalysis: Michael Addition Reaction with C-, N-, -, S- Nucleophiles and In-situ Diagnostics Debjit Das, a Sanjay Pratihar a,b and Sujit Roy c * a rganometallics
Διαβάστε περισσότεραChemistry 506: Allied Health Chemistry 2. Chapter 14: Carboxylic Acids and Esters. Functional Groups with Single & Double Bonds to Oxygen
Chemistry 506 Dr. Hunter s Class Chapter 14. Chemistry 506: Allied Health Chemistry 2 1 Chapter 14: Carboxylic Acids and Esters Functional Groups with Single & Double Bonds to Oxygen Introduction to General,
Διαβάστε περισσότεραSupporting Information. Introduction of a α,β-unsaturated carbonyl conjugated pyrene-lactose hybrid
Electronic Supplementary Material (ESI) for RSC Advances. This journal is The Royal Society of Chemistry 16 Supporting Information Introduction of a α,β-unsaturated carbonyl conjugated pyrene-lactose hybrid
Διαβάστε περισσότεραProtease-catalysed Direct Asymmetric Mannich Reaction in Organic Solvent
Supplementary information for the paper Protease-catalysed Direct Asymmetric Mannich Reaction in Organic Solvent Yang Xue, Ling-Po Li, Yan-Hong He * & Zhi Guan * School of Chemistry and Chemical Engineering,
Διαβάστε περισσότερα4 ο ΚΕΦΑΛΑΙΟ. Γ ε ν ε τ ι κ ή
4 ο ΚΕΦΑΛΑΙΟ Γ ε ν ε τ ι κ ή 1. Κύκλος της ζωής του κυττάρου 3ο Γελ. Ηλιούπολης επιμέλεια: Αργύρης Γιάννης 2 2. Μοριακή Γενετική i). Ροή της γενετικής πληροφορίας DNA RNA πρωτεΐνες νουκλεΐκά οξέα ή πρωτεΐνες
Διαβάστε περισσότεραof the methanol-dimethylamine complex
Electronic Supplementary Information for: Fundamental and overtone virational spectroscopy, enthalpy of hydrogen ond formation and equilirium constant determination of the methanol-dimethylamine complex
Διαβάστε περισσότεραVBA Microsoft Excel. J. Comput. Chem. Jpn., Vol. 5, No. 1, pp (2006)
J. Comput. Chem. Jpn., Vol. 5, No. 1, pp. 29 38 (2006) Microsoft Excel, 184-8588 2-24-16 e-mail: yosimura@cc.tuat.ac.jp (Received: July 28, 2005; Accepted for publication: October 24, 2005; Published on
Διαβάστε περισσότεραSUPPLEMENTARY MATERIAL
10.1071/CH16014_AC The Authors 2016 Australian Journal of Chemistry 2016, 69(9), 1049-1053 SUPPLEMENTARY MATERIAL A Green Approach for the Synthesis of Novel 7,11-Dihydro-6H-chromeno[3,4- e]isoxazolo[5,4-b]pyridin-6-one
Διαβάστε περισσότεραDietary success of a new key fish in an overfished ecosystem: evidence from fatty acid and stable isotope signatures
The following supplement accompanies the article Dietary success of a new key fish in an overfished ecosystem: evidence from fatty acid and stable isotope signatures M. G. van der Bank 1, A. C. Utne-Palm
Διαβάστε περισσότεραAvailable online at
J. Serb. Chem. Soc. 76 (12) S1 S5 (2011) Supplementary material SUPPLEMENTARY MATERIAL TO Synthesis of quinoline-attached furan-2(3h)-ones having anti-inflammatory and antibacterial properties with reduced
Διαβάστε περισσότεραA facile and general route to 3-((trifluoromethyl)thio)benzofurans and 3-((trifluoromethyl)thio)benzothiophenes
Electronic Supplementary Material (ESI) for ChemComm. This journal is The Royal Society of Chemistry 2014 A facile and general route to 3-((trifluoromethyl)thio)benzofurans and 3-((trifluoromethyl)thio)benzothiophenes
Διαβάστε περισσότεραDirect Transformation of Ethylarenes into Primary Aromatic Amides with N-Bromosuccinimide and I 2 -aq NH 3
Supporting Information Direct Transformation of Ethylarenes into Primary Aromatic Amides with N-Bromosuccinimide and I 2 -aq NH 3 Shohei Shimokawa, Yuhsuke Kawagoe, Katsuhiko Moriyama, Hideo Togo* Graduate
Διαβάστε περισσότεραΚεφάλαιο 1. Οι δομικοί λίθοι
Κεφάλαιο 1 Οι δομικοί λίθοι Κεφάλαιο 1 Οι Δομικοί Λίθοι των Πρωτεϊνών Εικόνα 1.1 Η αμινοξική αλληλουχία μιας πρωτεϊνικής πολυπεπτιδικής αλυσίδας ονομάζεται πρωτοταγής δομή. Διαφορετικές περιοχές της αλληλουχίας
Διαβάστε περισσότεραNew Cytotoxic Constituents from the Red Sea Soft Coral Nephthea sp.
SUPPLEMENTARY MATERIAL New Cytotoxic Constituents from the Red Sea Soft Coral Nephthea sp. Mohamed-Elamir F. Hegazy a,*, Amira M. Gamal-Eldeen b, Tarik A. Mohamed a, Montaser A. Alhammady c, Abuzeid A.
Διαβάστε περισσότεραAn experimental and theoretical study of the gas phase kinetics of atomic chlorine reactions with CH 3 NH 2, (CH 3 ) 2 NH, and (CH 3 ) 3 N
Electronic Supplementary Material (ESI) for Physical Chemistry Chemical Physics. This journal is the Owner Societies 2015 An experimental and theoretical study of the gas phase kinetics of atomic chlorine
Διαβάστε περισσότεραNational d Histoire Naturelle, 57 rue Cuvier (C.P. 54), Paris, France. Contents:
Electronic Supplementary Material (ESI) for Organic & Biomolecular Chemistry. This journal is The Royal Society of Chemistry 2017 Supporting Information Synthesis and Biological Evaluation of the Ascidian
Διαβάστε περισσότεραTable of Contents 1 Supplementary Data MCD
Electronic Supplementary Material (ESI) for Dalton Transactions. This journal is The Royal Society of Chemistry 2017 Supporting Information for Magnetic circular dichroism and density functional theory
Διαβάστε περισσότεραElectronic Supplementary Information
Electronic Supplementary Material (ESI) for Sustainable Energy & Fuels. This journal is The Royal Society of Chemistry 2018 Electronic Supplementary Information Proton coupled electron transfer from Co
Διαβάστε περισσότεραSelecting Critical Properties of Terpenes and Terpenoids through Group-Contribution Methods and Equations of State
Supporting Information Selecting Critical Properties of Terpenes and Terpenoids through Group-Contribution Methods and Equations of State Mónia A. R. Martins, 1,2 Pedro J. Carvalho, 1 André M. Palma, 1
Διαβάστε περισσότεραElectronic Supplementary Information. Carbon dioxide as a reversible amine-protecting
Electronic Supplementary Information Carbon dioxide as a reversible amine-protecting agent in selective Michael additions and acylations Annelies Peeters, Rob Ameloot and Dirk E. De Vos * Centre for Surface
Διαβάστε περισσότερα9-amino-(9-deoxy)cinchona alkaloids-derived novel chiral phase-transfer catalysts
Electronic Supplementary Material (ESI) for Organic & Biomolecular Chemistry. This journal is The Royal Society of Chemistry 2014 9-amino-(9-deoxy)cinchona alkaloids-derived novel chiral phase-transfer
Διαβάστε περισσότεραSupporting Information
Supporting Information On the Ambiguity of 1,3,2-Benzodiazaboroles as Donor/Acceptor unctionalities in Luminescent Molecules Lothar Weber *[a], Johannes Halama [a], Kenny Hanke [a], Lena Böhling [a], Andreas
Διαβάστε περισσότεραCopper-Catalyzed Oxidative Dehydrogenative N-N Bond. Formation for the Synthesis of N,N -Diarylindazol-3-ones
Electronic Supplementary Material (ESI) for Organic Chemistry Frontiers. This journal is the Partner Organisations 2016 Supporting information Copper-Catalyzed Oxidative Dehydrogenative - Bond Formation
Διαβάστε περισσότεραSupporting Information One-Pot Approach to Chiral Chromenes via Enantioselective Organocatalytic Domino Oxa-Michael-Aldol Reaction
Supporting Information ne-pot Approach to Chiral Chromenes via Enantioselective rganocatalytic Domino xa-michael-aldol Reaction Hao Li, Jian Wang, Timiyin E-Nunu, Liansuo Zu, Wei Jiang, Shaohua Wei, *
Διαβάστε περισσότεραIodine-catalyzed synthesis of sulfur-bridged enaminones and chromones via double C(sp 2 )-H thiolation
Electronic Supplementary Material (ESI) for Organic & Biomolecular Chemistry. This journal is The Royal Society of Chemistry 2017 Iodine-catalyzed synthesis of sulfur-bridged enaminones and chromones via
Διαβάστε περισσότεραSUPPORTING INFORMATION
SUPPORTING INFORMATION Heronamides A C, new polyketide macrolactams from an Australian marine-derived Streptomyces sp. A biosynthetic case for synchronized tandem electrocyclization. Ritesh Raju, Andrew
Διαβάστε περισσότεραMetal-free Oxidative Coupling of Amines with Sodium Sulfinates: A Mild Access to Sulfonamides
Electronic Supplementary Material (ESI) for RSC Advances. This journal is The Royal Society of Chemistry 2014 Supporting information for Metal-free Oxidative Coupling of Amines with Sodium Sulfinates:
Διαβάστε περισσότεραFree Radical Initiated Coupling Reaction of Alcohols and. Alkynes: not C-O but C-C Bond Formation. Context. General information 2. Typical procedure 2
Free Radical Initiated Coupling Reaction of Alcohols and Alkynes: not C-O but C-C Bond Formation Zhongquan Liu,* Liang Sun, Jianguo Wang, Jie Han, Yankai Zhao, Bo Zhou Institute of Organic Chemistry, Gannan
Διαβάστε περισσότεραSynthesis of Imines from Amines in Aliphatic Alcohols on Pd/ZrO 2 Catalyst at Ambient Conditions
This journal is The Royal Society of Chemistry 213 Synthesis of Imines from Amines in Aliphatic Alcohols on Pd/ZrO 2 Catalyst at Ambient Conditions Wenjing Cui, a Bao Zhaorigetu,* a Meilin Jia, a and Wulan
Διαβάστε περισσότερα1. Arrhenius. Ion equilibrium. ก - (Acid- Base) 2. Bronsted-Lowry *** ก - (conjugate acid-base pairs) HCl (aq) H + (aq) + Cl - (aq)
Ion equilibrium ก ก 1. ก 2. ก - ก ก ก 3. ก ก 4. (ph) 5. 6. 7. ก 8. ก ก 9. ก 10. 1 2 สารล ลายอ เล กโทรไลต (Electrolyte solution) ก 1. strong electrolyte ก HCl HNO 3 HClO 4 NaOH KOH NH 4 Cl NaCl 2. weak
Διαβάστε περισσότεραTable S1. Summary of data collections and structure refinements for crystals 1Rb-1h, 1Rb-2h, and 1Rb-4h.
Supporting Information [NH 3 CH 3 ] [In SbS 9 SH]: A novel methylamine-directed indium thioantimonate with Rb + ion-exchange property Kai-Yao Wang a,b, Mei-Ling Feng a, Jian-Rong Li a and Xiao-Ying Huang
Διαβάστε περισσότεραΗΜΟΚΡΙΤΕΙΟ ΠΑΝΕΠΙΣΤΗΜΙΟ ΘΡΑΚΗΣ ΤΜΗΜΑ ΜΟΡΙΑΚΗΣ ΒΙΟΛΟΓΙΑΣ ΚΑΙ ΓΕΝΕΤΙΚΗΣ ΓΟΝΙ ΙΑΚΗ ΕΚΦΡΑΣΗ ΚΑΙ ΣΗΜΑΤΟ ΟΤΗΣΗ
ΗΜΟΚΡΙΤΕΙΟ ΠΑΝΕΠΙΣΤΗΜΙΟ ΘΡΑΚΗΣ ΤΜΗΜΑ ΜΟΡΙΑΚΗΣ ΒΙΟΛΟΓΙΑΣ ΚΑΙ ΓΕΝΕΤΙΚΗΣ ΓΟΝΙ ΙΑΚΗ ΕΚΦΡΑΣΗ ΚΑΙ ΣΗΜΑΤΟ ΟΤΗΣΗ ρ. Α. ΓΑΛΑΝΗΣ agalanis@mbg.duth.gr Figure 6.1 The Biology of Cancer ( Garland Science 2007) Figure
Διαβάστε περισσότεραSUPPLEMENTARY INFORMATION
Sensitivity of [Ru(phen) 2 dppz] 2+ Light Switch Emission to Ionic Strength, Temperature, and DNA Sequence and Conformation Andrew W. McKinley, Per Lincoln and Eimer M. Tuite* SUPPLEMENTARY INFORMATION
Διαβάστε περισσότεραExtended dissolution studies of cellulose in imidazolium based ionic liquids
Electronic Supplementary Information Extended dissolution studies of cellulose in imidazolium based ionic liquids Jürgen Vitz, a,b Tina Erdmenger, a,b Claudia Haensch, a,b Stephanie Hornig # and Ulrich
Διαβάστε περισσότεραSupporting Information
Electronic Supplementary Material (ESI) for Dalton Transactions. This journal is The Royal Society of Chemistry 2016 Supporting Information Abnormal N-Heterocyclic Carbene Based Nickel Complex for Catalytic
Διαβάστε περισσότεραAnswers and Spectroscopic Assignments Copyright 2012
Organic Structure Elucidation - A Workbook of Unknowns www.nd.edu/~smithgrp/structure/workbook.html Answers and Spectroscopic Assignments Carleton G. Collins, Department of Chemistry and Biochemistry,
Διαβάστε περισσότεραMandelamide-Zinc Catalyzed Alkyne Addition to Heteroaromatic Aldehydes
1 Mandelamide-Zinc Catalyzed Alkyne Addition to Heteroaromatic Aldehydes Gonzalo Blay, Isabel Fernández, Alícia Marco-Aleixandre, and José R. Pedro Departament de Química Orgànica, Facultat de Química,
Διαβάστε περισσότεραZebra reaction or the recipe for heterodimeric zinc complexes synthesis
Electronic Supplementary Material (ESI) for Dalton Transactions. This journal is The Royal Society of Chemistry 05 Supporting Information Zebra reaction or the recipe for heterodimeric zinc complexes synthesis
Διαβάστε περισσότεραNovel and Selective Palladium-Catalyzed Annulation of 2-Alkynylphenols to Form 2-Substituted 3-Halobenzo[b]furans. Supporting Information
Novel and Selective Palladium-Catalyzed Annulation of 2-Alkynylphenols to Form 2-Substituted 3-Halobenzo[b]furans Liang Yun, Shi Tang, Xu-Dong Zhang, Li-Qiu Mao, Ye-Xiang Xie and Jin-Heng Li* Key Laboratory
Διαβάστε περισσότεραElectronic Supplementary Information
Electronic Supplementary Information Unprecedented Carbon-Carbon Bond Cleavage in Nucleophilic Aziridine Ring Opening Reaction, Efficient Ring Transformation of Aziridines to Imidazolidin-4-ones Jin-Yuan
Διαβάστε περισσότεραPyrrolo[2,3-d:5,4-d']bisthiazoles: Alternate Synthetic Routes and a Comparative Study to Analogous Fused-ring Bithiophenes
SUPPORTING INFORMATION Pyrrolo[2,3-d:5,4-d']bisthiazoles: Alternate Synthetic Routes and a Comparative Study to Analogous Fused-ring Bithiophenes Eric J. Uzelac, Casey B. McCausland, and Seth C. Rasmussen*
Διαβάστε περισσότεραSupporting Information
Supporting Information Aluminum Complexes of N 2 O 2 3 Formazanate Ligands Supported by Phosphine Oxide Donors Ryan R. Maar, Amir Rabiee Kenaree, Ruizhong Zhang, Yichen Tao, Benjamin D. Katzman, Viktor
Διαβάστε περισσότεραNickel and Platinum PCP Pincer Complexes Incorporating an Acyclic Diaminoalkyl Central Moiety Connecting Imidazole or Pyrazole Rings
ickel and Platinum PCP Pincer Complexes Incorporating an Acyclic Diaminoalkyl Central Moiety Connecting Imidazole or Pyrazole Rings Braulio M. Puerta Lombardi, Rudy M. Braun, Chris Gendy, Chia Yun Chang,
Διαβάστε περισσότεραSupporting Information
Supporting Information Wiley-VCH 27 69451 Weinheim, Germany Supplementary Figure 1. Synthetic results as detected by XRD (Cu-Kα). Simulation pattern of MCM-68 Relative Intensity / a.u. YNU-2P Conventional
Διαβάστε περισσότεραComparison of carbon-sulfur and carbon-amine bond in therapeutic drug: -S-aromatic heterocyclic podophyllum derivatives display antitumor activity
Comparison of carbon-sulfur and carbon-amine bond in therapeutic drug: -S-aromatic heterocyclic podophyllum derivatives display antitumor activity Jian-Long Li 1,a, Wei Zhao 1,a, Chen Zhou 1,a, Ya-Xuan
Διαβάστε περισσότεραSupporting Information. Asymmetric Binary-acid Catalysis with Chiral. Phosphoric Acid and MgF 2 : Catalytic
Supporting Information Asymmetric Binary-acid Catalysis with Chiral Phosphoric Acid and MgF 2 : Catalytic Enantioselective Friedel-Crafts Reactions of β,γ- Unsaturated-α-Ketoesters Jian Lv, Xin Li, Long
Διαβάστε περισσότεραElectronic Supporting Information
Electronic Supplementary Material (ESI) for Dalton Transactions. This journal is The Royal Society of Chemistry 2018 Electronic Supporting Information robing steric influences on electrophilic phosphonium
Διαβάστε περισσότεραΕισαγωγή στις πρωτεΐνες Δομή πρωτεϊνών Ταξινόμηση βάσει δομής Βάσεις με δομές πρωτεϊνών Ευθυγράμμιση δομών Πρόβλεψη 2D δομής Πρόβλεψη 3D δομής
Εισαγωγή στις πρωτεΐνες Δομή πρωτεϊνών Ταξινόμηση βάσει δομής Βάσεις με δομές πρωτεϊνών Ευθυγράμμιση δομών Πρόβλεψη 2D δομής Πρόβλεψη 3D δομής Τι είναι η πρωτεΐνη Τι εννοούμε με δομή πρωτεϊνών Οικογένειες
Διαβάστε περισσότεραReference Table: Projection NMR Nomenclature (August 2006)
Reference Table: Projection NMR Nomenclature (August 2006) Research Group Marion and Kozminski and Brutscher and Kupce and Freeman Projection NMR experiments (with Tilt angles) Equivalent GFT NMR experiment(s)
Διαβάστε περισσότεραSupporting Information. Experimental section
Electronic Supplementary Material (ESI) for RSC Advances. This journal is The Royal Society of Chemistry 2014 Supporting Information Experimental section General. Anhydrous solvents were transferred by
Διαβάστε περισσότεραSupplementary Information. Living Ring-Opening Polymerization of Lactones by N-Heterocyclic Olefin/Al(C 6 F 5 ) 3
Supplementary Information Living Ring-Opening Polymerization of Lactones by N-Heterocyclic Olefin/Al(C 6 F 5 ) 3 Lewis Pairs: Structures of Intermediates, Kinetics, and Mechanism Qianyi Wang, Wuchao Zhao,
Διαβάστε περισσότεραFe II aq Fe III oxide electron transfer and Fe exchange: effect of organic carbon
Supplementary materials Fe II aq Fe III oxide electron transfer and Fe exchange: effect of organic carbon Timothy Pasakarnis, A Michael L. McCormick, B Gene F. Parkin, A Aaron Thompson C and Michelle M.
Διαβάστε περισσότεραSupplementary Figure S1. Single X-ray structure 3a at probability ellipsoids of 20%.
Supplementary Figure S1. Single X-ray structure 3a at probability ellipsoids of 20%. S1 Supplementary Figure S2. Single X-ray structure 5a at probability ellipsoids of 20%. S2 H 15 Ph Ac Ac I AcH Ph Ac
Διαβάστε περισσότεραΑΡΙΣΤΟΤΕΛΕΙΟ ΠΑΝΕΠΙΣΤΗΜΙΟ ΘΕΣΣΑΛΟΝΙΚΗΣ ΓΕΩΠΟΝΙΚΗ ΣΧΟΛΗ ΤΟΜΕΑΣ ΕΠΙΣΤΗΜΗΣ ΚΑΙ ΤΕΧΝΟΛΟΓΙΑΣ ΤΡΟΦΙΜΩΝ ΜΑΡΙΑΣ ΦΩΤΙΟΥ ΠΤΥΧΙΟΥΧΟΥ ΓΕΩΠΟΝΟΥ
ΑΡΙΣΤΟΤΕΛΕΙΟ ΠΑΝΕΠΙΣΤΗΜΙΟ ΘΕΣΣΑΛΟΝΙΚΗΣ ΓΕΩΠΟΝΙΚΗ ΣΧΟΛΗ ΤΟΜΕΑΣ ΕΠΙΣΤΗΜΗΣ ΚΑΙ ΤΕΧΝΟΛΟΓΙΑΣ ΤΡΟΦΙΜΩΝ ΜΑΡΙΑΣ ΦΩΤΙΟΥ ΠΤΥΧΙΟΥΧΟΥ ΓΕΩΠΟΝΟΥ Συγκέντρωση των ελεύθερων αµινοξέων στο αµνιακό υγρό σε σχέση µε την εβδοµάδα
Διαβάστε περισσότεραSupplementary Materials for. Kinetic and Computational Studies on Pd(I) Dimer- Mediated Halogen Exchange of Aryl Iodides
Supplementary Materials for Kinetic and Computational Studies on Pd(I) Dimer- Mediated Halogen Exchange of Aryl Iodides Indrek Kalvet, a Karl J. Bonney, a and Franziska Schoenebeck a * a Institute of Organic
Διαβάστε περισσότεραEngineering Tunable Single and Dual Optical. Emission from Ru(II)-Polypyridyl Complexes. Through Excited State Design
Engineering Tunable Single and Dual Optical Emission from Ru(II)-Polypyridyl Complexes Through Excited State Design Supplementary Information Julia Romanova 1, Yousif Sadik 1, M. R. Ranga Prabhath 1,,
Διαβάστε περισσότεραFast healing of polyurethane thermosets using. reversible triazolinedione chemistry and shapememory
Supporting Information: Fast healing of polyurethane thermosets using reversible triazolinedione chemistry and shapememory Niels Van Herck and Filip E. Du Prez* Polymer Chemistry Research Group, Centre
Διαβάστε περισσότεραEffects of feeding reduced dietary CP with supplementation of synthetic AA on N and C. excretion, energy utilization, and fecal VFA concentrations.
Effects of feeding reduced dietary CP with supplementation of synthetic AA on N and C excretion, energy utilization, and fecal VFA concentrations. Aaron Jones, Brian Richert, Charlie Maxwell, Scott Radcliffe
Διαβάστε περισσότεραSolutions to the Schrodinger equation atomic orbitals. Ψ 1 s Ψ 2 s Ψ 2 px Ψ 2 py Ψ 2 pz
Solutions to the Schrodinger equation atomic orbitals Ψ 1 s Ψ 2 s Ψ 2 px Ψ 2 py Ψ 2 pz ybridization Valence Bond Approach to bonding sp 3 (Ψ 2 s + Ψ 2 px + Ψ 2 py + Ψ 2 pz) sp 2 (Ψ 2 s + Ψ 2 px + Ψ 2 py)
Διαβάστε περισσότεραElectronic Supplementary Information:
Electronic Supplementary Information: 2 6 5 7 2 N S 3 9 6 7 5 2 S N 3 9 Scheme S. Atom numbering for thione and thiol tautomers of thioacetamide 3 0.6 0. absorbance 0.2 0.0 0.5 0.0 0.05 0.00 N 2 Ar km/mol
Διαβάστε περισσότεραSupporting Information. Experimental section
Electronic Supplementary Material (ESI) for RSC Advances. This journal is The Royal Society of Chemistry 2014 Supporting Information Experimental section General. Proton nuclear magnetic resonance ( 1
Διαβάστε περισσότεραa 2,5 b 2,5 upplemental Figure 1 IL4 (4h) in Ja18-/- mice IFN-γ (16h) in Ja18-/- mice 1,5 1,5 ng/ml ng/ml 0,5 0,5 4ClPh PyrC 4ClPh PyrC
a 2,5 IL4 (4h) in Ja18-/- mice b 2,5 IFN-γ (16h) in Ja18-/- mice 2 2 ng/ml 1,5 ng/ml 1,5 1 1,5,5 4ClPh NC PyrC 4ClPh NC PyrC upplemental Figure 1 a b c PyrC-α-GalCer NU-α-GalCer α-galcer CD4 (PE) MFI CD4
Διαβάστε περισσότεραAvailable online at shd.org.rs/jscs/
J. Serb. Chem. Soc. 78 (1) S1 S8 (2013) Supplementary material SUPPLEMENTARY MATERIAL TO Metal complexes of N'-[2-hydroxy-5-(phenyldiazenyl)- benzylidene]isonicotinohydrazide. Synthesis, spectroscopic
Διαβάστε περισσότεραEntropic contribution of elongation factor P to proline. positioning at the catalytic center of the ribosome
S1 Supplementary Data for Entropic contribution of elongation factor P to proline positioning at the catalytic center of the ribosome Lili K. Doerfel, Ingo Wohlgemuth, Vladimir Kubyshkin, Agata L. Starosta,
Διαβάστε περισσότεραΚεφάλαιο 2ο. Αντιγραφή, έκφραση και ρύθμιση της γενετικής πληροφορίας
Κεφάλαιο 2ο Αντιγραφή, έκφραση και ρύθμιση της γενετικής πληροφορίας 1. Το DNA αυτοδιπλασιάζεται 3ο ε.λ. Ηλιούπολης επιμέλεια: Αργύρης Γιάννης 3 Ο μηχανισμός της αντιγραφής του DNA Ο μηχανισμός αυτοδιπλασιασμού
Διαβάστε περισσότεραElectronic Supporting Information. 3-Aminothiophenecarboxylic acid (3-Atc)-induced folding in peptides
Electronic Supplementary Material (ESI for New Journal of Chemistry. This journal is The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2016 Electronic Supporting Information
Διαβάστε περισσότεραMean bond enthalpy Standard enthalpy of formation Bond N H N N N N H O O O
Q1. (a) Explain the meaning of the terms mean bond enthalpy and standard enthalpy of formation. Mean bond enthalpy... Standard enthalpy of formation... (5) (b) Some mean bond enthalpies are given below.
Διαβάστε περισσότεραHeavier chalcogenone complexes of bismuth(iii)trihalides: Potential catalysts for acylative cleavage of cyclic ethers. Supporting Information
Electronic Supplementary Material (ESI) for RSC Advances. This journal is The Royal Society of Chemistry 2015 Heavier chalcogenone complexes of bismuth(iii)trihalides: Potential catalysts for acylative
Διαβάστε περισσότεραCarbohydrates in the gas phase: conformational preference of D-ribose and 2-deoxy-D-ribose
New J. Chem ELECTRONIC SUPPLEMENTARY INFORMATION Carbohydrates in the gas phase: conformational preference of D-ribose and 2-deoxy-D-ribose Luis Miguel Azofra,*, María Mar Quesada-Moreno, Ibon Alkorta,
Διαβάστε περισσότεραConductivity Logging for Thermal Spring Well
/.,**. 25 +,1- **-- 0/2,,,1- **-- 0/2, +,, +/., +0 /,* Conductivity Logging for Thermal Spring Well Koji SATO +, Tadashi TAKAYA,, Tadashi CHIBA, + Nihon Chika Kenkyuusho Co. Ltd., 0/2,, Hongo, Funabashi,
Διαβάστε περισσότεραSupplementary Table 1. Construct List with key Biophysical Properties of the expression
SPINE Benchmark Target ID Well Code Tag (N or C) Fusion MW (kda) Fusion pi Cleavage site Prot MW (Da) Prot pi 1 A1 OPPF 2585 N-His6 21.75 6.41 Protease 3C 19.77 5.43 2 B1 OPPF 2586 N-His6 15.6 6.27 Protease
Διαβάστε περισσότερα1.1 1., Litopenaeus vannamei N- -β-d- NAGase. Asp Glu. K I 9.50 mmol/l mmol/l. Litopenaeus vannamei
N--β-D- 1, 2 1 1 1., 361005 2. 362000 GlyAlaValLeu Ile Pro PheTrpSerThr Cys Gln AsnGlu AspHis LysArg 18 Litopenaeus vannamei N--β-D- pnp-nag NAGase L-His Lys Arg Asp Glu IC 50 20 28 mmol/l Asp Glu pnp-nag
Διαβάστε περισσότεραPeptidomimetics as Protein Arginine Deiminase 4 (PAD4) Inhibitors
Peptidomimetics as Protein Arginine Deiminase 4 (PAD4) Inhibitors Andrea Trabocchi a, icolino Pala b, Ilga Krimmelbein c, Gloria Menchi a, Antonio Guarna a, Mario Sechi b, Tobias Dreker c, Andrea Scozzafava
Διαβάστε περισσότεραThe Free Internet Journal for Organic Chemistry
The Free Internet Journal for Organic Chemistry Paper Archive for Organic Chemistry Arkivoc 2018, part iii, S1-S6 Synthesis of dihydropyranones and dihydropyrano[2,3- d][1,3]dioxine-diones by cyclization
Διαβάστε περισσότεραResurvey of Possible Seismic Fissures in the Old-Edo River in Tokyo
Bull. Earthq. Res. Inst. Univ. Tokyo Vol. 2.,**3 pp.,,3,.* * +, -. +, -. Resurvey of Possible Seismic Fissures in the Old-Edo River in Tokyo Kunihiko Shimazaki *, Tsuyoshi Haraguchi, Takeo Ishibe +, -.
Διαβάστε περισσότεραRoom Temperature Ionic Liquids from 20 Natural Amino Acids. Kenta Fukumoto, Masahiro Yoshizawa, and Hiroyuki Ohno
S1 Room Temperature Ionic Liquids from 20 Natural Amino Acids Kenta Fukumoto, Masahiro Yoshizawa, and Hiroyuki Ohno 1-Ethyl-3-methylimidazolium L-α-aminopropionic acid salt ([emim][ala]). From 1.0g (5.2mmol)
Διαβάστε περισσότεραNguyen Hien Trang* **
152 Nippon Shokuhin Kagaku Kogaku Kaishi Vol.., No.., +,+3 (,**1) 10 Nguyen Hien Trang* ** * Department of Food Science and Technology, Hue University of Agriculture and Forestry ** Properties of "Shishibishio
Διαβάστε περισσότεραSupporting Information
Supporting Information Copyright Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, 2014 A Family of Click Nucleosides for Metal-Mediated Base Pairing: Unravelling the Principles of Highly Stabilizing Metal-Mediated
Διαβάστε περισσότεραBIOXHMEIA, TOMOΣ I ΠANEΠIΣTHMIAKEΣ EKΔOΣEIΣ KPHTHΣ ΑΠΕΙΚΟΝΙΣΗ ΜΟΡΙΑΚΩΝ ΔΟΜΩΝ
BIOXHMEIA, TOMOΣ I ΠANEΠIΣTHMIAKEΣ EKΔOΣEIΣ KPHTHΣ ΑΠΕΙΚΟΝΙΣΗ ΜΟΡΙΑΚΩΝ ΔΟΜΩΝ ΑΠΕΙΚΟΝΙΣΗ ΜΟΡΙΑΚΩΝ ΔΟΜΩΝ ΜΟΡΙΑΚΑ ΜΟΝΤΕΛΑ 1: ΧΩΡΟΠΛΗΡΩΤΙΚΟ ΜΟΝΤΕΛΟ (SPACE-FILLING) 1: ΧΩΡΟΠΛΗΡΩΤΙΚΟ ΜΟΝΤΕΛΟ (SPACE-FILLING)
Διαβάστε περισσότερα1 1 1 2 1 2 2 1 43 123 5 122 3 1 312 1 1 122 1 1 1 1 6 1 7 1 6 1 7 1 3 4 2 312 43 4 3 3 1 1 4 1 1 52 122 54 124 8 1 3 1 1 1 1 1 152 1 1 1 1 1 1 152 1 5 1 152 152 1 1 3 9 1 159 9 13 4 5 1 122 1 4 122 5
Διαβάστε περισσότεραSupplementary Information Chemical Partition of the Radiative Decay Rate of Luminescence of Europium Complexes
Supplementary Information Chemical Partition of the Radiative Decay Rate of Luminescence of Europium Complexes Nathalia B. D. Lima [a], José Diogo L. Dutra [a,b], Simone M. C. Gonçalves [a], Ricardo O.
Διαβάστε περισσότεραSupporting Information for Iron-catalyzed decarboxylative alkenylation of cycloalkanes with arylvinylic carboxylic acids via a radical process
Supporting Information for Iron-catalyzed decarboxylative alkenylation of cycloalkanes with arylvinylic carboxylic acids via a radical process Jincan Zhao 1, Hong Fang 1, Jianlin Han* 1,2 and Yi Pan* 1
Διαβάστε περισσότεραchlorostibine Iou-Sheng Ke and François P. Gabbai Department of Chemistry, Texas A&M University, College Station, TX
σ-donor/acceptor confused ligands: The case of a chlorostibine Iou-Sheng Ke and François P. Gabbai Department of Chemistry, Texas A&M University, College Station, TX 77843-3255. *To whom correspondence
Διαβάστε περισσότερα