Retro viruses (Slow viruses)

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2 # ISBN

3 Retro viruses (Slow viruses)

11 B

12 Sulkin & Pike VEEVenezuelanEquine Encephalitis

13 Q

14 Skinhoj CDC NADC QQ

16 Q Fever Down the Drain Q Q Q Q

17 Q

22 Collins

23 Phillips

26 Reitman & Wedum

28 X X X X X X X X X X X X X X X X X X

30 Andersen Cascade Impactor

33 Martin

34 Oncogenic or Slow Viruses

35 Encephalitis LCM Marburg Herpes B (Hepatitis Gemalaya Hantan

36 Herpes B-virus LCM Marburg NDV Parainfluenza Reovirus (type 3) Rabies Antrax Brucella Diplococcus pneumonia E, coli Tularemia Listeria Mycotacterium Pasteurella multocida

37 Pasteurella pneumotropica Pseudomonas aeroginosa Q Fever Salmonella Shigella Staphylococcus Streptococcus Yersinia pestis Y. psuedotuberculosis

38 Voororst

39 SPF Staphylcoccus Pasteurella Huebner NIAID

41 up scaling

42 Simian viruses C C C C in vivo EBV

43 Infectious mononucleosis

44 C B Papilloma moderate Species barrier SA

45 DNA Marek s Polyoma Adenovirus Herpes Papilloma Shope fibroma Shope papilloma Shope lymphoma SV40 RNA Rous sarcoma Leucosis CELO Leukemia Sarcoma Mamary tumor Leukemia Graffi Leukemia Leukemia Sarcoma mast cells DNA Herpes virus saimirii Herpes virus ateles Yaba pox EBV Nondefective adeno SV hybrid RNA Feline leukemia Feline sarcoma Wooly monkey fibrosarcoma Gibbon ape lymphosarcoma

46 Slow viruses Retro viruses LCMlymphocytic choriomeningitislcm LCM LCM LCM LCM Huebner LCM LCM

47 Transmissible Spongiform Encephalopathy CJD Dimentia Kuru & Creutzfeldt-Jacoob Benefit-risk Benefit-cost Cost-effectiveness

49 CB B B HIV B CDC

50 HIV Western BlotEIA HIV CB

51 E coil K-12 HV Host VectorEK1 EK2 EK3 BL4 BL1 Szybalski

52 DNA toxins WR Vesicular stomatitis virusvsvn G 3x10 4 pfu/0.05 ml VSVN

53 NIHJ. Rivkin Environmental Impact Statement

54 Retro CDC

56 Wedum & Kruse A A Q VEE

57 CDC

59 freeze drying lyophilization

60 B B

61 Biosafety level 2 up scaling Kletz

62 Hazard and operability study - HAZOP Hazard analysis = HAZAN

63 Fisher Lincoln et al Batch

64 DNA

69 containment

70 National Institute of HealthNIHCenter for Disease ControlCDC (Good Laboratory Practices) GLP GLP

71 GLP GLP Federal Register (Good Manufacturing Practices) GMP GMP GMP GMP SOP - Standard Operation Procedures SOP SOP

72 (Code of Practice) COP GMP GLP COP

73 HEPA UV Air lock HEPA

75 Goggles

76 I II II PDF

77 III HEPA ή% I 1x 10-5 cc/sec at 2 w.g.*** pressure AII BII 1x10-5 cc/sec at 3 w.g. pressure III nnoή n/noή.w.g

78 II I BII AII III III

79 DNA II

80 HEPA UV

81 DOP Di Octyl PhtalateDOP HEPA

82 DOP HEPA HEPA HEPA HEPA

83 HEPA HEPA A B C III III HEPA

84 Host Vector HV-2HV-1 HV-1 E. Coli K-12 COL E1,pSC101 EK1 HV-2 EK2 DNA PFU

85 BL-3 HV-3 HV-1 HV2 HV2 BL2 BL4 BL3 BL3 BL3 BL3 BL3/HV2 HV1 HV2 BL3 BL2 BL3 BL3 BL3 BL3 BL3/HV1 HV1 HV2 BL4 BL3 BL4 BL4 BL4 BL4 BL4/HV1

86 B

87 TD MMR HBVB

88 B anti-hbs miu/ml anti-hbc HBsAg NIH P4P1protectionP P1 P2 P4P3

89 BSLBiosafety levelbl NIHCDC CDC NIH NCI CDC NIH WHO - BL1 P1 I C BL4 P2 II B BL3 P3 III A BL2 P4 IV BL1

90 BL1

91 BL2

93 III

94 BL

95 HEPA

96 III I II challenge Air lock

97 cfm fpm III HEPA interlock

98 BL III

100 III

101 HEPA HEPA HEPA

102 HEPA II I HEPA HEPA

103 CDC NIH 5/bmbl 5toc.htm

104 HEPA

105 HEPA HEPA Liberman C C C C

106

107 HEPA

108

109 Biosecurity

110

111

112

113 B

114

115 BL3 BL3 GLP, GMP

116

117 BL3 BL3 BL2 BL2 BL3 BL BL3

118 BL3

119 BL3

120 BL3

121

122 =Pounds per square inchpsi C

123 Gravity displacement HEPA C PSI

124 C C C C C

125 Bacillus stearothermophilus C C C

126 Bacillus subtilis C varniger B. subtilis C C

127 C C X

128 nm b

129

130 PPM 2CaOCl Na 2 S 2 O 2

131

132 b a d CO٢c c d c d g/ft 3 8%-0.2% 2% 23-8 g/ft 3 b 85%-70% b b 85%-70% %-1% 500 ppm a ppm a 10 2%-0.1% C

133 C C w/v C

134

135 HEPA HEPA Hz

136

137 C C

138

139

140 Infectious agent Contagious agent RetrovirusesRNA Slow viruses Arbo viruses Containment

141 High Efficiency Particulate Air HEPA Biological safety cabinet Glove box Safety cage

142 UV BL 1-4 = P 1-4 Biosafety levelbl ProtectionP NIH- EK 1-3 = HV 1-3 Host VectorHV;E. coli KEK - Plaque forming units PFU Up scaling Center for DiseaseCDC National Institutes of Health NIH Enzyme Immuno AssayAIE

143 Hazard Operability Study; Hazard-Analysis HAZOP ;HAZAN (Good Laboratory Practices) GLP (Good Manufacturing Practices) GMP Standard Operation Procedures SOP Code of PracticeCOP -Cubic feet per minutecfm -Feet per minutefpm

144 - V X G

145 הגורם Acinetobacter calcoaceticus 2 Actinobacillus actinoides Actinobacillus lignieresii 2 Actinobacillus suis 2 2 Actinomyces bovis 2 2 Actinomyces israelli 2 Aeromonas hydropphila 2 Araachnia propionica 2 2 Arizona hinshawii 2 2 Bacillus anthracis (v) 2 3 Bacillus cereus 1 1 Bacillus subtilis 2 2 Bacteroldes spp 2 Bartonella bacilliformis Bordetella bronchiseptica 2 Bordetella pertussis 2 3 Borrelia all spp 2 3 Brucella abortus 3 3 Brucella canis 3 3 Brucella melitensis 3 3 Brucella ovis 3 3 Brucella suis 3 Campylobacter fetus - subspecies fetus 3 Subspecies jejuni Subspecies intestinalis Chlamydia psittaci Chlamydia trachomatis Clostridium botulinum (v) Clostridium chauvoei Clostridium difficile Clostridium haemolyticum

146 Clostridium histolyticum Clostridium novyi Clostridium perfringens Clostridium septicum Clostridium sordellii Clostridium tetani (v) Corynebacterium bovis Corynebacterium diophtheriae Corynebacterium equi Corynebacterium ovis/pseudotuberculosis Corynebacterium ulcerans Corynebacterium haemolyticum Corynebacterium pyogenes Corynebacterium renale Edwardsiella tarda Enterobacter aerogenes Erysipelothrix insidosa Escherichia coli Escherichia coli, K 12 strain Francisella novicida Francisella tularensis Haemophilus ducreyi Haemophilus gallinarum Haemophilus haemolyticus Haemophilus influenzae Haemophilus parahaemolyticus Klebsiella pneumoniae Lactobacillus acidophilus Lactobacillus bulgaricus Lactobacillus casei Legionella pneumophila Legionella-like organisms Leptospira interrogans all serovars Listeria monocytogenes Mima polymorpha

147 Moraxella lacunata Moraxella osloensis Mycobacterium africanum Mycobacterium avium intracellulare Mycobacterium bovis Mycobacterium bovis (BCG strain) Mycobacterium chelonei Mycobacterium fortuitum Mycobacterium kansasii Mycobacterium leprae (G) Mycobacterium marinum Mycobacterium scrofulaceum Mycobacterium simiae Mycobacterium szulgei Mycobacterium tuberculosis Mycobacterium ulcerans (G) Mycobacterium xenopi Mycoplasma pneumoniae Neisseria gonorrhoeae Neisseria meningitldis Nocardia asteroldes Nocardia brasillensis Pasteurella haemolytica Pasteurella muftocida Pasteurella pneumotropica Plesiomonas shigelloides Proteus spp Pseudomonas aeroginosa Pseudomonas mallel (x) Pseudomonas pseudomallel Rickettsial Agents Coxiella burneti (v) Rickettsia akari Rickettsia canada Rickettsia conori Rickettsia montana

148 Rickettsia mooseri Rickettsia prowazeki (v) Rickettsia rickettsii (v) Rickettsia sennetsu Rickettsia tsutsugamushi Rochalima quintana Vole rickettsia Salmonella choleraesuis Salmonella entaritidis all serotypes Salmonella typhi (v) Serratia marcescens Shigella boydii Shigella dysenteriae Shigella flexneri Shigella sonnei Sphaerophorus necrophorus Staphylococcus aureus Staphylococcus epidermidis Streptobacillus moniliformis Streptococcus agalactiae Streptococcus pneumoniae Streptococcus pyogenes Treponema pailldum Treponema pertenue Vibrio cholerae (v) Vibrio parahaemolyticus Vibrio vulnificus Yersinia enterocolitica Yersinia pestis (v) Yersinia pseudotuberculosis

149 Absidia spp Aspergillus spp Blastomyces dermatitidis Candida spp Cladosporium trichoides Coccidioides immitis Cryptoccoccus neoformans Dermatophilus congolensis Epidermophyton spp Geotrichum spp Histoplasma capsulatum Histoplasma farciminosum (x) Loboa lobol Madurella mycetomi Microsporum spp Mucor spp Paracoccidioides brazilensis Rhizopus spp Sporothrix schenkii Trichophyton spp Trichosporon spp

150 Acanthocheilonema spp Acanthamoeba spp Ancylostoma spp Angiostrongyius spp Ascaris spp Babesia spp Balantldium spp Brugia spp Capillaria spp Clonorchis spp Cysticerus spp Dicrocoelium spp Dipetalonema spp Diphylobothrium spp Dipylidium spp Dracunculus spp Echinoccoccus spp Entamoeba histolytica Enterobius spp Fasciola spp Fasciolopsis spp Giardia spp Hymenolepsis spp Heterophyes spp Isospora spp Leishmania spp (G) Linguatula spp Loa spp Macracanthorhynchus spp Necator spp Naegleria fowleri 2 3 2

151 Naegleria gruberi Onchocerca spp Opisthorchis spp Paragonimus spp Plasmodium spp Pneumocystis carinii Schistosoma spp (G) Strongyioides spp Taenia spp Toxascaris spp Toxocara spp Toxoplasma spp Trichinella spp Trichomonas vaginalis Trichostrongylus spp Trichuris trichiura Trypanosoma spp (G) Wuchereria spp 2 2 2

152 Adenoviruses (human) 3 Arenaviruses Lymphocytic choriomeningitis Viscerotrophic strains Neurotrophic strains Coronaviruses Herpesvirus Group Herpesvirus hominis Cytomegalovirus Epstein-Barr virus Herpesvirus simiae Pseudo-rabies virus Varicella virus Myxo-Paramyxoviruses Canine distemper virus Canine distemper Virus (Snyder-Hill strain) Influenza viruses (excluding pandemic strains) Measles virus (v) Mumps virus (v) Newcastle disease virus Parainfluenza viruses (human isolates) Respiratorysyncitial virus Subsclerosing Panencephalitis virus 3 2 Picomaviruses Coxsackie viruses Echoviruses

153 Poliomyelitis virus (wild) (v) Poliomyelitis virus (attenutated) (v) Rhinoviruses (human) Poxviruses Cowpox virus Molluscum contagiousum virus Monkeypox virus (v) Orf virus Paravaccinia virus Tanapox virus Vaccinia virus (v) Variola major virus restricted RESTR ICTED Variola minor virus restricted RESTR ICTED Whitepox virus restricted RESTR ICTED Yabapox virus Papovaviruses SV 40 virus B-K virus Spongiform Encephalopathy Prions Creutzfeldt-Jacob agent (G) Kuru agent (G) Rotaviruses Togaviruses Rubella virus (v) Ungrouped Agents Fifth Disease Agent Hepatitis viruses (G) Norwalk agent Human Immunomodefeciency Virus (HIV) 2 3 2

154 Absettarov Aino Akabane Araguari Batama Batken Bhanja Bimbo Bluetongue-indigenous Bluetongue-Exotic Bobaya Bobia Buenaventura Cabassou Chikungunya Chim Cocal Congo Dhori Dugbe Eastern Equine Encephalitis (v) Ebola Everglades (v) Ganjam (x) Garba Germiston Getah Gordil Guaratuba Hanzalova Hypr 4 4 4

155 Ibaraki Inhangapi Inini Israel Turkey Men Issyk-Kui Itaituba Japanese Encephalitis Junin Kairi (x) Khasan Koutango Kumlinge Kyasanur Forest Disease Kyzylagach Lassa Louping ill (x) Machupo Marburg Mayaro Middelburg Mosqueiro Mucambo (v) Murray Valley Encephalitis Nairobi Sheep Disease (x) Nariva Ndumu Negishi New Minto Nodamura Northway Omsk Hemorrhagic Fever Oropouche Orungo Ouango Oubangui Paramushir 3 3 3

156 Piry Ponteves Powassan Razdan Rift Valley Fever (vx) Rochambeau Rocio Russian Spring-Summer Enc Sagiyama Sakpa Salanga Santa Rosa Saumarez Reef Semilki Forest Seplik Serra do Navio Slovakia Spondweni St. Louis Encephalitis Tamdy Telok Forest Tlacotalpan Tonate Venezuelan Equine Enc. (v) (*) VEE (TC83) (v) VS-Alagoas VS-indiana VS-New Jersey Wesselsbron (x) Western Equine Enc. (v) West Nile (*) Yellow Fever (17D) (v) Zinga 3 3 3

157 ANSI,ISO,DIN,EN IntenationalISO Standard Office Deutsche Industrie NormaDIN American National Standard InstituteANSI

158

159 Laboratory Aquired Infections. C.H. Collins (ed.), Butterworth & Co. London, Laboratory safety. Theory and Practice. A.A. Fuscaldo. B.J. Erich & B,J, Hindman (eds.), Academic Press. New York, NIH Laboratory Safety Monograph. A Supplement to the NIH Guidelines for Recombinant DNA Research. U.S. Dept. of H.E.W. Pub. Health Service/ N.I.H. July, NIH Biohazards Safety Guide. U.S. Dept. of H.E.W. Pub. Health Service Handbook of Laboratory Safety. N.V. Steere. The Chemical Rubber Co, Ohio, Biohazards in Biological Research. A. Hellman, M.N. Oxman & L.R. Pollack (eds.), Cold Spring Harbor Laboratory, Biosafety in Microbiological and Biomedical Laboratories. U.S.D.H.S. Public Health Service. Center for Disease Control & National Institute of Health, Laboratory Safety Manual. World Health Organization. Geneva, Laboratory Safety: Principles and Practices. D.O. Fleming (ed.), American Society of Microbiology, Washington, Israeli, E. Biosafety: in Biotechnological Processes. A Mizrahi (ed.), Advances in Biotechnological Processes.Vol. 6, Alan R. Liss, Inc. New York. 1986

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