2003 November 19 (6) Chin J Neurosci 405 ( 510280) [ ] Tourette [ ] ; ; Structure and f unction of dopamine receptors L I Fan SHU Si2yun BAO Xin2min ( I nstit ute f or Neu roscience of Fi rst M ilitary Medical U niversity Zhujiang Hospital Guangz hou 510280 China ) [ Abstract] Dopamine (DA) is the most abundant catecholaminergic neurotransmitter in the brain. The involvement and importance of DA as a neurotransmitter in the regulation of different physiological functions in the central nervous sys2 tem ( CNS) are well know. Deregulation of the dopaminergic system has been linked with Parkinson disease Tourette syndrome schizophrenia attention deficit hyperactive disorder(adhd) and generation of pituitary tumours. This review focuses on the pharmacological and biochemical features shared by the dopamine receptors. The distribution of the differ2 ent dopamine receptors in the CNS and their function especially associated with learning and memory are emphasized. [ Key words] dopamine ; dopamine receptor ; learning and memory Ξ ( ) 30 : Tourette ( l2dopa) 80 % : (1) ; (2) ; (3) ; (4) 1 ( TH) 3 42 DOPA (SNC) ( ) Ξ [ ] 100820872 (2003) 0620405206 [ ] R981 ; R338 [ ] A [ ] 2003205220 [ ] [ ] 020261643275 [ E2mail] shusybao @gdvnet. com [ ] (19712).
406 2003 11 19 6 D2 D1 ( D1 (V TA ) D5) DA2R TATA CAAT V TA ( ) (OT) D22R ( RARE) D1 D2 4 2 mrnas (72GM) G D1 D2 [1 ] (DA2R) D12R ( CPu) ( Acb) D1 D1 D5 ( D 1A Calleja D 1B ) D2 D2 D3 D4 D1 mrna C :D12R [2 ] D52R D12R D1 D2 D22R mrna CPu OT Acb : D1 SCH223390 (V TA) SKF238393 D1 D5 D22R D1 [5 ] D2 mrna D2L D22R mrna D32R 3 DA2Rs D22R cdna cdna 1245 D42R mrna 415 [3 ] D2S(D2 short) D2 ( D1 D5 ) ( ) [6 \ D2L (D2 long) D2 D1 D5 8 7 29 :D1 D5 D2L D2S [3 ] D2 D1 D5 [6 ] D1 D3 446 D1 D5 GABA cdna D3 D5 [3 ] Chi n J Neurosci November 2003 19 (6) [4 ] [3 D1 D2 (OT) (Cx) ] D1 mrna Callija D32R [7 ; ] : D1 D4 5 387 D1 D5 D1 D5 [6 7 D42R 48 7 ] D1
407 D5 D22R Ca 2 + D22R : D1 D5 Ca 2 + D1 D1 D5 TH Ca 2 + / ( CaM CaM ) CaM Ca 2 + 2 :D2 D1 D1 AMP2 D1 D2 [7 ] D2 ( D2 N G108215 ) D22R D2L D2S G D4 GABA 5. 3 D22R D4 GABA (AA) Ca 2 + D4 D22R CHO AA D12R [8 GABA ] AA PTX D22R D1 D22R 5 [3 AA D12R ] 6 : D22R 6. 1 GTP2 G2 D2L G i22 : D2S 5. 1 D1 (camp) A( PKA) PKA D1 D2 D1 D2 G (D124) D2 D12 (AC) D2 R camp D22R AC ( PTX) D32R [9 ] D22R camp D22R [10 ] D32R D42R camp 5. 2 D32R D42R GH4CI D12R PKA L2 Ca 2 + N2 P2 Ca 2 + 6. 2 D12R T2 Ca 2 + D12R camp D2 G i/ 0 (DAT) D2L D2S G 0 Ca 2 + D22R G i N2 Ca 2 + [11 ]
408 2003 11 19 6 D1 D22R D12R NMDA2R D2 quinpirole ( bromocriptine) Wilkerson [21 ] D22R D12R D22R Umegaki [22 ] D22R 14 T ( ) D22R D32R D42R D22R Greba [23 ] D22R 6. 3 Smith [24 ] D22R A10 D2L 2/ 2 [12 ] Watanabe [13 ] D2L2R Da Cunha [14 ] D2 D32R MPTP METH (metaphetamine) D22R D12R Phillips [15 ] D22R ; D22R 6. 4 Rosenkranz [16 ] PET Chi n J Neurosci November 2003 19 (6) Wi D1 D2 D12R De keyser J [25 ] (PFC) Sawaguchi D12R [17 ] DA sulpirde SCH23390 Hemby PFC DA SE [26 ] RNA cdna PFC Kozlov [18 ] CA1 D12D5 D12R mrna El2Ghundi 6. 5 ( LTP) [19 ] D12R Mana2 Y D1 han2vaughan [27 ] D1 D2 Baldwin remoxipride L TP ( < 4 h) D2 [20 ] D12 L TP R NMDA2R
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