Ihuoma Eneli, MD, MS; Katayoun Sadri, MD; Carlos Camargo, Jr, MD, DrPH, FCCP; and R. Graham Barr, MD, DrPH ( ) 63% FEV 1 15% (acetaminophen); (asthma); (bronchoconstriction) 30 75% 5 160% [1] From the Sparrow Hospital Pediatric Residency Program (Dr. Sadri) and Department of Pediatrics and Human Development ( ); (Dr. Eneli), Michigan State University, Lansing, MI; Department of Emergency Medicine (Dr. Camargo), Massachusetts [2~9] General Hospital, Harvard Medical School, Boston, MA; and Department of Medicine (Dr. Barr), College of Physicians & TH 2 Surgeons, Mailman School of Public Health, Columbia ( ) [4,6,10] [4,6,7] University, New York, NY. [6,10] Correspondence to: Ihuoma Eneli, MD, MS, Department of Pediatrics and Human Development, Michigan State University, B220 Clinical Center Bldg, East Lansing, MI 48824-1313; e-mail: Eneli@msu. edu 1967 Chafee [11] 1 www.chestjournal.org.cn CHEST 2005 8 2 8 511
1 2000 1994 1995 ECHRIS 1 g 13 ~ 14 Newson [29] [1] 0.52% 0.26% 1995 ICU 8 (33%) Baudouin [30] 24 (89% 13%) 2000 16 ~ 51 OR 1.06 (95%CI 0.77 ~ 1.45); Shaheen [31] 720 OR 1.22 (95%CI 0.87 ~ 1.72); ( 51%) OR 1.79 (95%CI 1.21 ~ 2.65); 980 ( 49%) OR 2.38 (95%CI 1.22 ~ 4.64); P = 0.000 2 2002 9 400 20 ~ 32 wk Shaheen [32] 6 mo (OR 6 mo 2.34 95%CI 1.24 ~ 4.40) Barr [33] 2004 73 321 ( 44 ~ 69 P = 0.006 RR 1.63 95%CI 1.11 ~ 2.39) 1999 2 765 12mg/kg Lesko [34,35] 2002 2 (RR 0.56 95%CI 0.34 ~ 0.95); (RR 0.63 95%CI 0.25 ~ 1.6) [12] Kogan [12] > 30 d 2 / 3 ( ) (I.U.E. K.S.) [1] 22 [13~28] 1966 2002 PUBMED IOWA Cochrane 512
1 [29] Newson [29] (1976 121 700 30 ~ 55 ) [33] 1990 1992 (European Community Respiratory Health 1990 1996 [ Survey ECHRIS) RR 1.63 95%CI 1.11 ~ 2.39 P = 0.006] 1994 1995 13 ~ 14 1 g ( P = 0.03) ( P = 0.52% ECHRIS 0.12) 1 g 0.26% (P = 0.000 5) [32] Avon (Avon Longitudinal Study of Parents and Children ALSPAC) (1 574 ) 9 400 18 ~ 20 32 [31] ( ) (> 1 mo) 64% (P = 0.000 2) 20 ~ 32 30 ~ 42 mo 2 6 mo (OR 2.34 (OR 1.79 95%CI 1.21 ~ 2.65) 95%CI 1.24 ~ 4.40) (OR 8.2 95%CI ( 2.8 ~ 23) ) 6 mo (OR 2.73 95%CI 1.57 ~ 4.76) 1.5% 0.9% www.chestjournal.org.cn CHEST 2005 8 2 8 513
Lesko [34] [36~51] 84 000 2 1 879 Schwarz [39] 1 13 (RR 0.56 325 mg FEV 1 95%CI 0.34 ~ 0.95) [35] [45] FVC 20% (RR 5 500 ~ 1 000 mg 0.63 95%CI 0.25 ~ 1.6) 50 1 000 ~ 1 500 mg 34% FEV 1 15% ( P = 0.001 3) [41] ( ) 20% ~ 30% [42] [40~42] 2 / mg Szczeklik [37] 300 Szczeklik [38] 150 ~ 600 Spector [47] 650 Ellis [48] 32 Van Diem [51] 200 Leung [45] 500 ~ 1 000 Schwarz [39] 325 Galindo [50] 500 Kivity [36] Grant [46] Fischer [49] Stricker [44] Ayonrinde [43] 64 ~ 500 50 600 Falliers [40] 30 ~ 1 000 Settipane [42] 1 000 Settipane [41] 1 000 ~ 1 500 3 2 FEV 1 20% FVC FEV 1 C3 C4 2 3 4 IgE FEV 1 20% 2 3 FEV 1 FEF 25~75 20% 2 FEV 1 FEF 25~75 30% 44 5 68 FEV 1 16% ~ 33% 34% (P = 0.001 3) 514
[44] [62,63] 68 [43] 15 [30] ; [52] [64] 1 g [65] 2 wk (reactive oxygen species ROS) (O 2- ) (. OH) 1 (ROO - ) [53,54,56] ROS 1 (L-γ- -L- - ) ROS 95% [53] [54~56] [57] ROS [66,67] [54,58~60] [68,69] -S- [55,61] FVC FEV 1 [61] [70] Wu [71] -H 2 O 2 IgE (1) P450 N- N- N- (1) [72,73] ( ) 1 (1) www.chestjournal.org.cn CHEST 2005 8 2 8 515
[53] Dimova [64] IgE [15,50] de Paramo [15] 4 30 250 500 mg P450 IgE 250 500 mg 2 IgE [74,75] T 1 IgE [16,51] TH 2 IgE ( ) [77] 8 ( ) IgE FEV 1 19% 61% Bagnato [76] 12 FEV 1 ROS C4 D4 [17,24,78] ROS ROS, ( ) [33] Avon [32] ( -2- ) -2 E 2 TH 2 [9,77] TH 1 IgE Davey 516
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