ΚΛΕΙΩ Π. ΜΑΥΡΑΓΑΝΗ Στοιχεία Επικοινωνίας Εργαστήριο Πειραματικής Φυσιολογίας Ιατρική Σχολή - Πανεπιστήμιο Αθηνών Μ. Ασίας 75 115 27 Αθήνα Τηλέφωνο: 210 746 2714 Fax: 210 746 2571 e-mail: kmauragan@med.uoa.gr Εκπαίδευση Πτυχίο Iατρικής Σχολής Πανεπιστημίου Αθηνών: 1995 Άδεια άσκησης Ιατρικής στις ΗΠΑ(ECFMG): 2004 Μεταπτυχιακοί Τίτλοι: Α. Δίπλωμα Εσωτερικής Παθολογίας (Diploma Internal Medicine), Imperial College School of Medicine, University of London, 2000. Β. Διδακτορική διατριβή, Τμήμα Παθολογικής Φυσιολογίας Ιατρικής Σχολής Πανεπιστημίου Αθηνών, 2001.
Μετεκπαίδευση 1995-1999: Εργαστήριο Παθολογικής Φυσιολογίας, Εκπόνηση διδακτορικής διατριβής με τίτλο ««Ρόλος των αντί-ro/ssa αντισωμάτων στην παθογένεση των εμβρυϊκών αποβολών σε ασθενείς με αυτοάνοσα νοσήματα» 1999-2000: Imperial College School of Medicine, University of London, Hammersmith Campus, London, UK 2000-2004: Ειδικότητα Ρευματολογίας, Κλινική Παθολογικής Φυσιολογίας, Ιατρική Σχολή Πανεπιστημίου Αθηνών 2004-2008: Μεταδιδακτορικός υπότροφος, Hospital for Special Surgery/Weill Medical College, Cornell University, New York, NY, USA Διακρίσεις-Υποτροφίες Υποτροφία Ιδρύματος Κρατικών Υποτροφιών (ΙΚΥ), 1993 Υποτροφία Ιδρύματος Παπαδάκη, 1994 Βραβείο ακαδημαϊκής επίδοσης, Imperial College, University of London, UK,2000 Υποτροφία Ιδρύματος Σ.Νιάρχου για μετεκπαίδευση στη Ρευματολογία/Ανοσολογία, 2004-2006, Ηospital for Special Surgery/Weill Medical College, Cornell University, NY USA Υποτροφία Ελληνικής Ρευματολογικής Εταιρείας, (Βουδούρη-Παπαπαύλου), 2009
Eρευνητικά ενδιαφέροντα Διερεύνηση του ρόλου ενδογενών νουκλεϊκών οξέων στην ενεργοποίηση της οδού της ιντερφερόνης τύπου Ι σε συστηματικά αυτοάνοσα νοσήματα. Διερεύνηση του ρόλου της ιντερφερόνης τύπου Ι ως βιοδείκτη πρόγνωσης και ανταπόκρισης σε βιολογικές θεραπείες σε ασθενείς με σύνδρομο Sjogren και ρευματοειδή αρθρίτιδα. Διερεύνηση αλληλεπίδρασης των οδών ιντερφεόνης τύπου Ι και παράγοντα νέκρωσης των όγκων στην παθογένεση των αυτοανόσων νοσημάτων. ΔΗΜΟΣΙΕΥΣΕΙΣ 1. Mavragani CP, La D, Stohl W, Crow MK. Association of TNF-antagonist response in a predominantly Hispanic rheumatoid arthritis cohort with type I interferon activity: a post-hoc analysis. Arthritis Rheum In Press 2. Mavragani CP, Moutsopoulos HM. The geoepidemiology of Sjögren's syndrome. (2009) Autoimmun Rev. Nov 7. Epub before print. 3. Mavragani, C.P., Danielides, S., Zintzaras, E., Vlachoyiannopoulos, P.G., Moutsopoulos, H.M. Antithyroid antibodies in antiphospholipid syndrome: Prevalence and clinical associations. (2009) Lupus, 18 (12), pp. 1096-1099. 4. Mavragani, C.P., Skopouli, F.N., Moutsopoulos, H.M. Increased prevalence of antibodies to thyroid peroxidase in dry eyes and mouth syndrome or sicca asthenia polyalgia syndrome. (2009) Journal of Rheumatology, 36 (8), pp. 1626-1630. 5. Cantaert, T., De Rycke, L., Mavragani, C.P., Wijbrandts, C.A., Niewold, T.B., Niers, T., Vandooren, B., Veys, E.M., Richel, D., Tak, P.P., Crow, M.K., Baeten, D. Exposure to nuclear antigens contributes to the induction of humoral autoimmunity during tumour necrosis factor alpha blockade. (2009) Annals of the Rheumatic Diseases, 68 (6), pp. 1022-1029. 6. Karageorgaki ZT, Bertsias GK, Mavragani CP, Kritlkos HD, Spyropoulou-Vlachou M, Drosos AA, Boumpas DT, Moutsopoulos HM. Takayasu arteritis: epidemiological, clinical, and immunogenetic features in Greece. Clinical and Experimental Rheumatology, 27 (1): S33-S39 Suppl. 52 Jan-Feb 2009 7. *Karaiskos, D., *Mavragani, C.P., Makaroni, S., Zinzaras, E., Voulgarelis, M., Rabavilas, A., Moutsopoulos, H.M. Stress, coping strategies and social support in patients with primary Sjogren's syndrome prior to disease onset: A retrospective case-control study (2009) Annals of the Rheumatic Diseases, 68 (1), pp. 40-46. *equal contribution 8. Dastmalchi, M., Grundtman, C., Alexanderson, H., Mavragani, C.P., Einarsdottir, H., Barbasso Helmers, S., Elvin, K., Crow, M.K., Nennesmo, I., Lundberg, I.E. A high incidence of disease flares
in an open pilot study of infliximab in patients with refractory inflammatory myopathies (2008) Annals of the Rheumatic Diseases, 67 (12), pp. 1670-1677. 9. Zonios, D., Mavragani, C.P., Giaglis, S., Ritis, K. A novel mutation of the familial Mediterranean fever gene in a Greek family related to a non-classical, variably expressed FMF phenotype (2007) Rheumatology International, 28 (2), pp. 167-169. 10. Mavragani, C.P., Niewold, T.B., Moutsopoulos, N.M., Pillemer, S.R., Wahl, S.M., Crow, M.K. Augmented interferon-α pathway activation in patients with Sjögren's syndrome treated with etanercept. (2007) Arthritis and Rheumatism, 56 (12), pp. 3995-4004. 11. Mavragani, C.P., Yiannakouris, N., Zintzaras, E., Melistas, L., Ritis, K., Skopouli, F.N. Analysis of SAA1 gene polymorphisms in the Greek population: Rheumatoid arthritis and FMF patients relative to normal controls. Homogeneous distribution and low incidence of AA amyloidosis (2007) Amyloid, 14 (4), pp. 271-275. 12. Tsavaris, N., Mavragani, C.P., Dimitrios, P. Rheumatoid arthritis: Correlation between rheumatoid factor levels and CA-125 tumour marker elevation [1] (2007) Annals of the Rheumatic Diseases, 66 (7), p. 980. 13. Kirou, K.A., Mavragani, C.P., Crow, M.K. Activation of type I interferon in systemic lupus erythematosus (2007) Expert Review of Clinical Immunology, 3 (4), pp. 579-588. 14. Mavragani, C.P., Moutsopoulos, H.M. Conventional therapy of Sjogren's syndrome (2007) Clinical Reviews in Allergy and Immunology, 32 (3), pp. 284-291. 15. Karageorgaki, Z.T., Mavragani, C.P., Papathanasiou, M.A., Skopouli, F.N. Infliximab in Takayasu arteritis: A safe alternative? (2007) Clinical Rheumatology, 26 (6), pp. 984-987. 16. Mavragani, C.P., Patronas, N., Dalakas, M., Moutsopoulos, H.M. Ill-defined neurological syndromes with autoimmune background: A diagnostic challenge (2007) Journal of Rheumatology, 34 (2), pp. 341-345. 17. Mavragani, C.P., Voulgarelis, M. Retroperitoneal fibrosis and c-anca positivity (2007) Clinical Rheumatology, 26 (1), pp. 115-116. 18. Mavragani, C.P., Danielides, M.I., Moutsopoulos, H.M. Systemic autoimmune manifestations: When should underlying thyroid autoimmunity be considered? (2006) Current Rheumatology Reviews, 2 (4), pp. 345-348. 19. Kirou K, Mavragani CP. TNF antagonists in the management of early rheumatoid arthritis: An overview. Intern J of Adv in Rheum 2006; 4:49-56. 20. Mavragani, C.P., Moutsopoulos, N.M., Moutsopoulos, H.M. The management of Sjögren's syndrome (2006) Nature Clinical Practice Rheumatology, 2 (5), pp. 252-261. 21. Mavragani, C.P., Batziou, K., Aroni, K., Pikazis, D., Manoussakis, M.N. Alleviation of polyarticular syndrome in multicentric reticulohistiocytosis with intravenous zoledronate [4] (2005) Annals of the Rheumatic Diseases, 64 (10), pp. 1521-1522 22. Mavragani, C.P., Vlachoyiannopoulos, P.G. Is polydipsia sometimes the cause of oxcarbazepineinduced hyponatremia? (2005) European Journal of Internal Medicine, 16 (4), pp. 296-297. 23. Mavragani, C.P., Moutsopoulos, H.M. mm nos ppression and imm nomod la on in Sjögren's syndrome - What is the evidence? Does it relieve the sicca symptoms? [Immunsuppression und immunmodula on eim Sjögren-syndrom - Was ist bewiesen? Lindert sie die siccasymptome?] (2005) Aktuelle Rheumatologie, 30 (1), pp. 66-70. 24. Vlachoyiannopoulos, P.G., Mavragani, C.P., Bourazopoulou, E., Balitsari, A.V., Routsias, J.G. Anti- CD40 antibodies in antiphospholipid syndrome and systemic lupus erythematosus (2004) Thrombosis and Haemostasis, 92 (6), pp. 1303-1311. 25. Mavragani, C.P., Soliotis, F.C., Moutsopoulos, H.M. Nervous System Involvement in Sjogren's Syndrome (2004) Handbook of Systemic Autoimmune Diseases, 3, pp. 239-252. 26. Mavragani, C.P., Vlachoyiannopoulos, P.G., Kosmas, N., Boletis, I., Tzioufas, A.G., Voulgarelis, M. A case of reversible posterior leucoencephalopathy syndrome after rituximab infusion [4] (2004) Rheumatology, 43 (11), pp. 1450-1451.
27. Bodman-Smith, M.D., Corrigall, V.M., Berglin, E., Cornell, H.R., Tzioufas, A.G., Mavragani, C.P., Chan, C., Rantapää-Dahlqvist, S., Panayi, G.S. Antibody response to the human stress protein BiP in rheumatoid arthritis (2004) Rheumatology, 43 (10), pp. 1283-1287. 28. Soliotis, F.C., Mavragani, C.P., Moutsopoulos, H.M. entral nervo s system involvement in Sjögren's syndrome (2004) Annals of the Rheumatic Diseases, 63 (6), pp. 616-620. 29. Mavragani, C.P., Pikazis, D., Aroni, K., Paikos, S., Voulgarelis, M. Cutaneous ulcers: An unusual manifestation of inherited thrombophilia (2004) American Journal of Hematology, 76 (2), pp. 139-142. 30. Mavragani, C.P., Moutsopoulos, H.M. Lupus nephritis: Current issues (2003) Annals of the Rheumatic Diseases, 62 (9), pp. 795-798. 31. Mavragani, C.P., Vlachaki, E., Voulgarelis, M. re red cell aplasia in a Sjögren's syndrome/lupus erythematosus overlap patient (2003) American Journal of Hematology, 72 (4), pp. 259-262. 32. Mavragani, C.P., Paikos, S., Doussis-Anagnostopoulou, I., Voulgarelis, M. Midfacial swelling and oro-nasal involvement in a 53-year-old patient with bilateral pulmonary infiltrations (2001) Clinical and Experimental Rheumatology, 19 (5), pp. 577-581. 33. Mavragani, C.P., Tzioufas, A.G., Moutsopoulos, H.M. Sjogren's syndrome: Autoantibodies to cellular antigens: Clinical and molecular aspects (2000) International Archives of Allergy and Immunology, 123 (1), pp. 46-57. 34. Mavragani, C.P., Ioannidis, J.P.A., Tzioufas, A.G., Hantoumi, I.E., Moutsopoulos, H.M. Recurrent pregnancy loss and autoantibody profile in autoimmune diseases (1999) Rheumatology, 38 (12), pp. 1228-1233. 35. Mavragani, C.P., Moutsopoulos, H.M. Rheumatoid arthritis in the elderly (1999) Experimental Gerontology, 34 (3), pp. 463-471. 36. Mavragani, C.P., Dafni, U.G., Tzioufas, A.G., Moutsopoulos, H.M. Pregnancy outcome and anti- Ro/SSA in autoimmune diseases: A retrospective cohort study (1998) British Journal of Rheumatology, 37 (7), pp. 740-745.