1380 * ( 510405) R969 R691.6 A 1673-6273(2012)07-1380-04 Progress of the Study of Drug-Induced Renal Function Impairment* CHEN Hao, MI Sui-qing, ZHAO Wei (Institute of Clinical Pharmacology Guangzhou University of Traditional Chinese Medicine Guangzhou 510405 China) ABSTRACT: Kidney is the one of the main organs which has rich blood and big oxygen consumption in body. Drugs are mainly used to help body against diseases, but it also can produce damages to organs. Most of the drugs and their metabolites excrete through kidney; therefore, renal drug concentration dramatically increased and it probably brings about damages to kidney. To investigate the mechanism of drug induced kidney injuries is particularly important to protect kidney far from damages and to reduce risks of drug development and renal drug usage in clinics. This article aims at summarizing researches on mechanisms of drugs induced acute kidney injuries. Key words: Drugs; Kidney injury; Mechanism; Toxicity Chinese Library Classification(CLC): R969, R691.6 Article ID:1673-6273(2012)07-1380-04 Document code: A 109h [1] 1991-2007 22 18 1.1.2 β- 1 : 1.1 [2 3] 1.1.1 98%-99% 1.1.3 ph<5.5 [4] * "211 " [ 2009 972 ] 1988-15920554875 E-mail chenhao211@126.com E-mail: athena_zw@126.com 2011-08-07 2011-08-31
1381 24-48h 25% 50% 1.1.4 Fujisaki [13] B -1 20%-80% uet/cr uet/cr [5] 1.6 1.1.5 1.6.1 AA Selby [6] 10% ~48% (ARF) 20 80 [7] 1.1.6 (AAN) [14] 35 2001 2007 [8] 8 90 120 [15] 33 87 32-86 1.2 ( ) B 31 PozdzikA [16] AAN -3 Jiang AA, p53, AA [9] Bax Bak 25 [17] 1.3 Fanconi 4 3%-5% 1.6.2 2h [10] 30-65 1 18-2 kg 90% 1.4 70% 20g/kg.d A 5d 1 100g [11] 10%-40% [18] 1.6.3 [12] 1.5 2 4 6- MDA -SH GSH SOD GSH-Px
1382 [19] PLA2 2.1.4 reactive oxygen species ROS GSH Dieterich C [23] BALB/c 7 400mg/kg 8 2 ROS 2.1 Rokushima M 2.1.1 CER 2.1.1.1 [24] [25] [20] SD MDA -SH 3h SOD GSH-Px GSH DDP ATP (Na + -K + -ATP ) K + 2.2 Na + -K + -ATP Na + 2.2.1 2.1.1.2 ER ER TGF-β1, Qi X AA, ADP/ATP, ER, [26] A2(PLA2), [21], 2.1.2, [27], Col, 2.2.2 - - (RAA) HgCl 2 Polderman MDCK 24h MD- CK LDH [22] MDCK 2.1.3 [28] 2.2.3
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