13 1 Vol 13 No 1 2012 2 JOURNAL OF BEIHUA UNIVERSITY Natural Science Feb 2012 1009-4822 2012 01-0068-05 132013 R587 2 A Progress on Pathogenesis of Diabetic Nephropathy LI Na SUN Hui WANG Tuo ZHAN Jin-zhuo HAN Xiao AN Li-ping DU Pei-ge Pharmacy College of Beihua University Jilin 132013 China Abstract Pathogenesis of diabetic nephropathy involves genetic susceptibility sugar metabolism disorders lipid metabolism disorders renal hemodynamics inflammation cytokines and so on which we can look for the most effective methods for the prevention and treatment of diabetic nephropathy Key words diabetes nephropathy pathogenesis progress in research DN DN DN DN Ⅱ1 1 DN AT1R ACE MTH-FR 2 20% ~ 40% AR β CBS DN 4 3 DN 60% AGT -1 GLUT-1 DN -6 IL-6 E DN β1 TGF-β1 DN DN 5-6 1 GWAS Pima 4 3 7 9 20 DN 10p15 3 7q21 3 18q22 3 2011-12-03 YYZX 201124-2 1987-1963 -
1 14q23 1 DN 7 DN PKC 17 PKC β TGF-β 2 2 1 DN 18 PKC DN 19 2 4 8 AR SDH AR SDH AR DN ROS 9 2 2 AGEs 20 ROS PKC AGEs DN 10 AGEs DN ROS AngⅡ DN 11 AGEs 13 RAGE NF -κb DN MAPK Rac /Cdc42 Jak /Stat Ras 12 AGEs TGF-β1 AngⅡ 13 AGEs 21 DN DN 14 AGEs -1 PKC MCP-1 α TNF-α DN 2 3 C PKC PKC PKC 4 15 PKC PKC-β DM PKC 22 DM NADH / NAD + DN 11 DN DAG PKC 16 AGE-RAGE Ⅳ PKC VEGF PKC PAI-I ROS 3 DN 23 69
70 CTGF DN 4 1-1 MCP-1 DN MCP-1 MCP-1 5 1 β TGF-β MCP-1 TGF-β IL-1 IL-6 ICAM-1 DN TGF-β ⅡMP PAI 4 2 -α TNF-α 4 3 C CRP DN CRP CTGF 36 CTGF DN CDK CDKIs 26 DN G1 CTGF 27 28 Ⅱ smad7 TGF-β CRP CRP DN CRP DN 32 DN TNF-α ICAM-1 MCP-1 CRP 5 3 VEGF VEGF DN 29-30 4 4-6 IL-6 IL-6 - TGF-β VEGF VEGF 31 IL-6 37 VEGF IL-6 VEGF IL- VEGF MAP 6 DN 38 VEGF ERP 5 DN 32 Ina 33 TNF-α TGF-β smad 24 Ⅱ TNF-α DN DN TGF-β TNF-α DN 34 5 2 CTGF TGF-β IL-1 IL-6 25 DN CTGF 35 - - TGF-β CTGF AGEs PKC Ⅳ 39 DN 5 4 1 IGF-1 13 DN IGF-1 TGF-β β VEGF PDGF IGF-1
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