-1 (MIC-1) 229 MIC-1, CEA CA125 NSE CYFRA21-1 SCC [ ] MIC-1 (P<0.001) MIC % 96.5% MIC-1 MIC-1 MIC-1. doi: /j.issn

Σχετικά έγγραφα
BGP TRACP-5b BGP TRACP-5b P 0.05

Relationship between Connective Tissue Diseases and Thyroid Diseases

A Systematic Review of Procalcitonin for Early Detection of Septicemia of Newborn

ΣΤΑΔΙΟΠΟΙΗΣΗ ΚΑΡΚΙΝΟΥ ΠΝΕΥΜΟΝΑ ΕΚΤΙΜΗΣΗ ΑΝΑΤΟΜΙΚΗΣ ΕΚΤΑΣΗΣ ΝΟΣΟΥ

Μελέτη της έκφρασης του ογκοκατασταλτικού γονιδίου Cyld στον καρκίνο του μαστού

IL - 13 /IL - 18 ELISA PCR RT - PCR. IL - 13 IL - 18 mrna. 13 IL - 18 mrna IL - 13 /IL Th1 /Th2

8 η έκδοση σταδιοποίησης NSCLC. Τι άλλαξε, που κατευθύνεται; Ιωάννης Γακίδης, MD, MSc. Χειρουργός Θώρακος Γ.Ν. Αττικής «ΚΑΤ»

Cellular Physiology and Biochemistry

ΕΘΝΙΚΟ ΜΕΤΣΟΒΙΟ ΠΟΛΥΤΕΧΝΕΙΟ ΣΧΟΛΗ ΗΛΕΚΤΡΟΛΟΓΩΝ ΜΗΧΑΝΙΚΩΝ ΚΑΙ ΜΗΧΑΝΙΚΩΝ ΥΠΟΛΟΓΙΣΤΩΝ

CAO Yin-fang DING Hai-tao

0.877 χ 2 =0.51 P 0.05

Measurement of C1 Inhibitor Function by Colorimetric Method and Its Usage in the Diagnosis of Hereditary Angioedema

Μαρία Κατσιφοδήμου. Ο ρόλος της έκκρισης HLA-G από τα ανθρώπινα έμβρυα στην επιτυχία της εξωσωματικής γονιμοποίησης. Μεταπτυχιακή Διπλωματική Εργασία

Evaluation of the Efficacy of Olopatadine Hydrochloride in the Treating Allergic Rhinitis A Multicenter Randomized Double-blind Double-dummy Study

LUO, Hong2Qun LIU, Shao2Pu Ξ LI, Nian2Bing

Experimental Study of Dielectric Properties on Human Lung Tissue

Study on Purification Technology and Antioxidant Activity of Total Flavonoid from Eriobotryae Folium

DCIS MR GE SIGNA HDX 1. 5T T1 T2. Magnetic Resonance Imaging MRI TR / GE Vibrant. 2. 0mL 1.

Effects of soothing liver and invigorating spleen recipes of TCM on hepatic inflammatory cytokines of rats with nonalcoholic steatosishepatitis

PE CVVH PE+HP HP+CVVH HP+CVVH+PE CVVH. ENLAV of HCO - 3 ENLAV-HCO ± μmol /L HP+PE HP+CVVH HP+CVVH+PE

Basic & Clinical Medicine PLGA MUC1 MUC1 IC 50 MUC1 +

Supporting Information

CK8 / % 63 /76 P < A doi /j. issn

Contents Part I Psychoneuroimmunology and Systems Biology Mechanisms 1 From Psychoneuroimmunology to Personalized, Systems, and Dynamical Medicine

High mobility group 1 HMG1

R GHRP rh- GH

c Key words: cultivation of blood, two-sets blood culture, detection rate of germ Vol. 18 No

ΠΕΡΙΣΤΑΤΙΚΑ ΑΝΑΤΟΜΙΚΩΝ ΠΑΡΑΛΛΑΓΩΝ- ΑΝΩΜΑΛΙΩΝ ΤΩΝ ΑΓΓΕΙΩΝ ΚΑΤΑ ΤΗΝ ΠΡΟΣΠΕΛΑΣΗ ΔΙΑ ΤΗΣ ΚΕΡΚΙΔΙΚΗΣ ΑΡΤΗΡΙΑΣ ΣΕ ΜΙΚΡΗ ΣΕΙΡΑ ΑΣΘΕΝΩΝ.

Πρόγραμμα Ογκολογίας Ουροποιογεννητικού GenitoUrinary Oncology

Comparative Study on Determinations of BTEX in Soils from Industrial Contaminated Sites

ΜΕΤΑΠΤΥΧΙΑΚΑ ΣΕΜΙΝΑΡΙΑ ΠΝΕΥΜΟΝΟΛΟΓΙΑΣ

Ερευνητική Εργασία. A Study of Demographic Characteristics and Exposure to Known Risk Factors of Greek Patients with Actinic Keratosis (Attica Study)

Η ΙΑΓΝΩΣΤΙΚΗ ΚΑΙ ΠΡΟΓΝΩΣΤΙΚΗ ΑΞΙΑ ΤΗΣ ΟΣΤΕΟΠΟΝΤΙΝΗΣ (OPN) ΣΤΟΝ ΚΑΡΚΙΝΟ ΠΝΕΥΜΟΝΑ

Antimicrobial Ability of Limonene, a Natural and Active Monoterpene

Ο νοσηλευτικός ρόλος στην πρόληψη του μελανώματος

TNF TNF Karnofsky [6] /L /L 90 g/l 1 >3. rmhtnf. rmhtnf. rmhtnf. rmhtnf [3-5] rmhtnf 400 U/m 2 CR.

MSM Men who have Sex with Men HIV -

NF-κB TSLP. Expression of TSLP and NF-κB in patients with adenomyosis

Gro wth Properties of Typical Water Bloom Algae in Reclaimed Water

PET/CT versus DWI-MRI στην ογκολογία του θώρακος. Ευθυμιάδου Ρωξάνη Τμήμα Αξονικής, Μαγνητικής Τομογραφίας & PET-CT ΔΘΚΑ «Υγεία»

CPT. Tsuchiya. beta. quantitative RT PCR QIAGEN IGFBP. Fect Transfection Reagent sirna. RT PCR RNA Affymetrix GeneChip Expression Array

ΕΟΝΙΚΟ ΚΑΙ ΚΑΠΟΔΙΣΤΡΙΑΚΟ ΠΑΝΕΠΙΣΤΗΜΙΟ ΑΘΗΝΩΝ ΙΑΤΡΙΚΗ ΣΧΟΛΗ ΤΟΜΕΑΣ ΜΟΡΦΟΛΕΙΤΟΥΡΓΙΚΟΣ ΕΡΓΑΣΤΗΡΙΟ ΙΣΤΟΛΟΓΙΑΣ & ΕΜΒΡΥΟΛΟΓΙΑΣ

Δ.Ν.Έξαρχος Τμήμα CT-MRI&PET/CT Γ.N.Α «Ο Ευαγγελισμός»

ΤΕΧΝΟΛΟΓΙΚΟ ΠΑΝΕΠΙΣΤΗΜΙΟ ΚΥΠΡΟΥ ΣΧΟΛΗ ΕΠΙΣΤΗΜΩΝ ΥΓΕΙΑΣ ΤΜΗΜΑ ΝΟΣΗΛΕΥΤΙΚΗΣ ΠΤΥΧΙΑΚΗ ΕΡΓΑΣΙΑ ΕΠΗΡΕΑΖΕΙ ΤΗΝ ΠΡΟΛΗΨΗ ΚΑΡΚΙΝΟΥ ΤΟΥ ΜΑΣΤΟΥ

Optimizing Microwave-assisted Extraction Process for Paprika Red Pigments Using Response Surface Methodology

Development of the Nursing Program for Rehabilitation of Woman Diagnosed with Breast Cancer

Supplementary information:

ΤΕΧΝΟΛΟΓΙΚΟ ΠΑΝΕΠΙΣΤΗΜΙΟ ΚΥΠΡΟΥ ΣΧΟΛΗ ΕΠΙΣΤΗΜΩΝ ΥΓΕΙΑΣ. Πτυχιακή διατριβή. Ονοματεπώνυμο: Αργυρώ Ιωάννου. Επιβλέπων καθηγητής: Δρ. Αντρέας Χαραλάμπους

Supporting Information

0. 35g kg ~ 2. 0cm 10min. Nar- 15μL 6mm

ΤΕΧΝΟΛΟΓΙΚΟ ΠΑΝΕΠΙΣΤΗΜΙΟ ΚΥΠΡΟΥ ΣΧΟΛΗ ΕΠΙΣΤΗΜΩΝ ΥΓΕΙΑΣ. Πτυχιακή Εργασία. Κόπωση και ποιότητα ζωής ασθενών με καρκίνο.

Παιδιατρική ΒΟΡΕΙΟΥ ΕΛΛΑΔΟΣ, 23, 3. Γ Παιδιατρική Κλινική, Αριστοτέλειο Πανεπιστήμιο, Ιπποκράτειο Νοσοκομείο Θεσσαλονίκης, 2

< (0.999) Graft (0.698) (0.483) <0.001 (0.698) (<0.001) (<0.001) 3 months (0.999) (0.483) (<0.001) 6 months (<0.

Accumulation of Soil Arsenic by Panax notoginseng and Its Associated Health Risk

8Q5SAC) 8Q5SAC UV2Vis 8500 ( ) ; PHS23C ) ;721 ( ) :1 4. ;8Q5SAC : molπl ;Britton2Robinson Q5SAC BSA Britton2Robinson,

ΑΡΙΣΤΟΤΕΛΕΙΟ ΠΑΝΕΠΙΣΤΗΜΙΟ ΘΕΣΣΑΛΟΝΙΚΗΣ ΤΜΗΜΑ ΟΔΟΝΤΙΑΤΡΙΚΗΣ ΕΡΓΑΣΤΗΡΙΟ ΟΔΟΝΤΙΚΗΣ ΚΑΙ ΑΝΩΤΕΡΑΣ ΠΡΟΣΘΕΤΙΚΗΣ

Gerard A. Silvestri, MD, FCCP; and M. Patricia Rivera, MD, FCCP NSCLC EGFR NSCLC EGFR EGFR NSCLC. (epidermal growth factor receptor);

Φλοιοεπινεφριδιακό καρκίνωμα(adrenocortical

Octretide joint proton pump inhibitors in treating non-variceal gastrointestinal bleeding a Metaanalysis

Monday 26 January2015

1-4 certified reference material CRM. DSC HPLC ± 0. 4 % k = 2 P = GBW

The toxicity of three chitin synthesis inhibitors to Calliptamus italicus Othoptera Acridoidea

Σταδιοποίηση του καρκίνου του πνέυμονα. Καλκάνης Αλέξανδρος, Πνευμονολόγος

PCR. Detection of Promoter Hypermethylation of WIF-1 Gene by Nested Methylation Specific Polymerase Chain Reaction in Lung Cancer Patients

J Clin Exp Pathol 2015 Mar http / /www. cnki. net /kcms /detail / R html. anaplastie lymphoma kinase ALK ALK

ΤΕΧΝΟΛΟΓΙΚΟ ΠΑΝΕΠΙΣΤΗΜΙΟ ΚΥΠΡΟΥ ΣΧΟΛΗ ΓΕΩΠΟΝΙΚΩΝ ΕΠΙΣΤΗΜΩΝ ΒΙΟΤΕΧΝΟΛΟΓΙΑΣ ΚΑΙ ΕΠΙΣΤΗΜΗΣ ΤΡΟΦΙΜΩΝ. Πτυχιακή εργασία

TGFp FSH INH INH

Γεράσιµος Αλιβιζάτος ιευθυντής Γ Ουρολογικής Κλινικής Νοσοκοµείου ΥΓΕΙΑ

«ΑΓΡΟΤΟΥΡΙΣΜΟΣ ΚΑΙ ΤΟΠΙΚΗ ΑΝΑΠΤΥΞΗ: Ο ΡΟΛΟΣ ΤΩΝ ΝΕΩΝ ΤΕΧΝΟΛΟΓΙΩΝ ΣΤΗΝ ΠΡΟΩΘΗΣΗ ΤΩΝ ΓΥΝΑΙΚΕΙΩΝ ΣΥΝΕΤΑΙΡΙΣΜΩΝ»

καρκίνος στομάχου έχει θέση η ακτινοθεραπεία; Ιωάννης Γεωργακόπουλος Ακτινοθεραπευτής Ογκολόγος

Chin J Osteoporos April 2011 Vol 17 No. 4 Published online www. wanfangdate. com. cn doi / j. issn

UroSwords I (ΚΥΠ) Μονοθεραπεία ή συνδυαστική φαρμακοθεραπεία; Η μονοθεραπεία είναι επαρκής. Χαράλαμπος Κ. Μαμουλάκης Λέκτορας Ουρολογίας

ΑΤΣΟΑΝΟΗ ΠΑΓΚΡΕΑΣΙΣΙΔΑ. ηέξγηνο Γειαθίδεο Γαζηξεληεξνιόγνο

chronic kidney disease CKD A Survey and Analysis of Chinese Patent Medicine for Outpatients with Chronic Kidney Disease SU Guobin LIU

Μοριακή Διαγνωστική. Σύγχρονες Εφαρμογές Μοριακής Διαγνωστικής. Κλινική Χημεία ΣΤ Εξάμηνο - Παραδόσεις

ACTA CHINESE MEDICINE. diabetic nephropathies DN 24. urine protein quantitation in 24 hours 24hUTP serum creatinine Scr

ΚΕΡΚΙΔΙΚΗ ΚΑΙ ΜΗΡΙΑΙΑ ΠΡΟΣΠΕΛΑΣΗ ΣΕ ΣΤΕΦΑΝΙΟΓΡΑΦΙΕΣ ΚΑΙ ΑΓΓΕΙΟΠΛΑΣΤΙΚΕΣ. ΜΙΑ ΣΥΓΚΡΙΤΙΚΗ ΜΕΛΕΤΗ

Research of postpartum depression and progesterone estradiol change before and after childbirth

Inhibition of mushroom tyrosinase by flavonoid from Sorbus tianschanica Ruper in Xinjiang

( ) , ) , ; kg 1) 80 % kg. Vol. 28,No. 1 Jan.,2006 RESOURCES SCIENCE : (2006) ,2 ,,,, ; ;

Application of Statistical Process Control in Pretreatment Production Process of Gardenia jasminoides

þÿ ɺÁ Ä ÅÂ, ±»Î¼ Neapolis University þÿ Á̳Á±¼¼± ¼Ìù±Â ¹ º à Â, Ç» Ÿ¹º ½ ¼¹ºÎ½ À¹ÃÄ ¼Î½ º±¹ ¹ º à  þÿ ±½µÀ¹ÃÄ ¼¹ µ À»¹Â Æ Å

ΤΕΧΝΟΛΟΓΙΚΟ ΠΑΝΕΠΙΣΤΗΜΙΟ ΚΥΠΡΟΥ ΣΧΟΛΗ ΕΠΙΣΤΗΜΩΝ ΥΓΕΙΑΣ

CHEST COPD (ELISA) CXCL9 CXCL10 CXCL11 CCL5

Supplementary Materials: A Preliminary Link between Hydroxylated Metabolites of Polychlorinated Biphenyls and Free Thyroxin in Humans

RFA : HCC. percutaneous acetic acid injection therapy: PAIT 3 percutaneous hot water injection therapy: PHot 4 HCC HCV HCC

XIE Hong-juan ZHANG Shu-jun XIA Qun et al.

Stress Relaxation Test and Constitutive Equation of Saturated Soft Soil

Chin J Parasitol Parasit Dis Dec. 2008, Vol. 26, No.6. 9 ; B 30 min,

ΠΑΝΕΠΙΣΤΗΜΙΟ ΙΩΑΝΝΙΝΩΝ ΑΝΟΙΚΤΑ ΑΚΑΔΗΜΑΪΚΑ ΜΑΘΗΜΑΤΑ

Copper-catalyzed formal O-H insertion reaction of α-diazo-1,3-dicarb- onyl compounds to carboxylic acids with the assistance of isocyanide

ΕΦΑΡΜΟΓΗ ΕΥΤΕΡΟΒΑΘΜΙΑ ΕΠΕΞΕΡΓΑΣΜΕΝΩΝ ΥΓΡΩΝ ΑΠΟΒΛΗΤΩΝ ΣΕ ΦΥΣΙΚΑ ΣΥΣΤΗΜΑΤΑ ΚΛΙΝΗΣ ΚΑΛΑΜΙΩΝ

Vol. 36, pp , 2008 : PDT EBUS field cancerization EBUS PDT PDT. field cancerization PDT PDT NCI. dysplasia, metaplasia

Βηηακίλε D θαη Αλάινγα

Table S1. Summary of data collections and structure refinements for crystals 1Rb-1h, 1Rb-2h, and 1Rb-4h.

CorV CVAC. CorV TU317. 1

ΤΕΧΝΟΛΟΓΙΚΟ ΠΑΝΕΠΙΣΤΗΜΙΟ ΚΥΠΡΟΥ ΣΧΟΛΗ ΕΠΙΣΤΗΜΩΝ ΥΓΕΙΑΣ. Πτυχιακή εργασία ΑΓΧΟΣ ΚΑΙ ΚΑΤΑΘΛΙΨΗ ΣΕ ΓΥΝΑΙΚΕΣ ΜΕ ΚΑΡΚΙΝΟΥ ΤΟΥ ΜΑΣΤΟΥ ΜΕΤΑ ΑΠΟ ΜΑΣΤΕΚΤΟΜΗ

The Korean Journal of Cytopathology 12(2): 81-87, 2001

Μοριακή βάση της νόσου Alzheimer. Δαρδιώτης Ε. Λέκτορας Νευρολογίας Πανεπιστήμιο Θεσσαλίας

Electrolyzed-Reduced Water as Artificial Hot Spring Water

Transcript:

-1,,,,, (, 100021) :[ ] -1 () [ ] ELISA 324 48 229, CEA CA125 NSE CYFRA21-1 SCC [ ] (P<0.001) (P<0.001) 71.3%96.5% CEA CA125 NSE SCC CYFRA21-1; (~ ), 5 ( :66.7% vs 47.6%, :71.7% vs 65.0%);6 77.1%83.3% [ ] : -1; ; :R734.2 :A :1004-0242(2015)05-0421-05 doi:10.11735/j.issn.1004-0242.2015.05.a015 Clinical Application of Serum Macrophage Inhibitory Cytokine-1 for Diagnosis of Lung Cancer SHEN Di,WANG Xiao-bing,CHE Yi-qun,et al. (Cancer Hospital of Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021,China) Abstract:[Purpose] To investigate the clinical value of macrophage inhibitory cytokine-1 () as a serum tumor marker for the diagnosis of lung cancer. [Methods] The double antibody sandwich ELISA was used to detect serum level in 324 cases with lung cancer,48 cases with benign pulmonary disease and 229 healthy persons. Serum CEA,CA125,NSE,CYFRA21-1and SCC levels were also detected. [Results] concentration in lung cancer group was significantly higher than that in healthy persons group (P<0.001)and in benign disease group (P<0.001). The specificity and sensitivity of for lung cancer were 96.5% and 71.3% respectively. The sensitivity of for early stage of lung cancer was higher than that of CEA,CA125,NSE,SCC and CYFRA21-1 respectively. The sensitivity of for early stage of lung cancer (stage and stage ) was higher than the combination of the above five markers (stage :66.7% vs 47.6%; stage :71.7% vs 65.0%). The sensitivity for stage and stage reached 77.1% and 83.3% respectively in the combination of the six markers. [Conclusions] Serum level might be an ideal marker in diagnosis for lung cancer. Key words:macrophages inhibitory cytokine-1;tumor marker;lung cancer;diagnosis, -1()TGF-β,, :2014-12-29; :2015-01-27 : 863 (2008AA02Z415); (LC2012A12); (81441080) :,E-mail:qijun5610@126.com, [1] 2015 24 5 421

, 1.3 [2~5] 1 SPSS18.0, Kruskal-Wallis H, Mann-Whitney U ROC 1.1, P<0.05, 2 2011 9 2013 5 324, 206, 118, 27~87, 58.8±9.6 2.1 48, 20, 28, 23~75, 53.2±10.5 : 18,, 13, 8, 6 (P<0.001), 2, 1 (P<0.001) (Table 1), Table 1 Serum level in different patients(pg/ml) 229, 127, Group N P 25 P 50 P 75 102, 18~80, 51.4±11.4 Lung cancer 324 940.11 1346.28 1826.63 1.2 Benign disease 48 667.07 848.12 1239.80 Normal control 229 213.07 367.46 592.59 4ml; 30min,4 4000rpm 2.2 15min ; -80 (P=0.531),, (P=0.022) ELISA, (T) (N) (M)~ 450 450nm 655nm, ~ (P>0.05) (Table 2) [6] 2.3 Cobas601 ROC (area under (Roche) (CEA) curve,auc)0.912(95%ci:0.886~0.939) 125(CA125) (NSE) ROC, (CYFRA21-1), I2000 1000pg/ml, (Abbott) 71.3%96.5%(Figure 1) (SCC), 2.4,, 5ng/ml, CEA CA125 NSE SCC 35U/ml 18ng/ml 1.5ng/ml 3.3ng/ml, CYFRA21-1 ( 66.7% 16.2% 4.8% 97% ; 1.0% 13.3%22.9%, 71.7% 21.7%, 8.3% 5.0% 33.3% 48.3%, 68.4% 422 2015 24 5

Table 2 The association between levels and clinicopathological feature Clinicopathological features N P 25 P 50 P 75 Pathological type Squamous cell carcinoma 91 918.99 1383.53 1854.57 Adenocarcinoma 193 932.53 1245.43 1877.48 Small cell carcinoma 26 946.51 1341.63 1761.37 Sarcomatoid carcinoma 7 1039.66 2086.13 3680.03 Others* 7 1198.06 1574.50 1757.96 Differentiation High 57 786.09 1092.78 1486.87 Middle~Low 186 969.77 1371.61 1876.64 T stage T 1 54 764.40 1199.56 1591.20 T 2 167 964.35 1319.87 1875.79 T 3 48 877.22 1368.60 1809.53 T 4 31 1039.24 1391.50 2348.13 N stage N 0 142 959.63 1298.19 1853.57 N 1 ~N 3 150 878.68 13317.19 1778.63 Mstage M 0 240 900.19 1317.72 1940.06 M 1 78 1036.01 1426.50 1765.86 Stage ~ 164 927.04 1324.43 1868.38 ~ 160 962.73 1360.97 1862.63 Others:adenosquamous carcinoma and carcinoid tumor Sensitivity 1.0 0.8 0.6 0.4 0.2 0.0 0.0 0.2 0.4 0.6 0.8 1.0 1-Specificity P value 0.531 0.022 0.344 0.672 0.308 0.629 CA125 NSE SCC CYFRA21-1 ( :66.7% vs 47.6%, : 71.7% vs 65.0%)(Table 3), 5 (100%,7/7), (73.1%,19/26), (71.4%,65/ 91), (68.9%,133/193)(Table 4) 3-1 (),, [7],,,, [2,3,8] Koopmann [9], (P<0.05) CA199 ROC 0.99 0.78;, CA199 ROC 0.81 0.74,, CA199 ( Figure 1 The ROC curve of in diagnosis of early stage lung cancer ) 39.2% 25.3% 21.5% [3,9,10] 31.6%53.2%,, 80.0% 56.3% 45.0% 31.3% 20.0%58.8%), (~ ), CEA 2015 24 5 423

Table 3 Tumor marker Total 1. 66.7 71.7 68.4 80.0 71.3 2.CEA 16.2 21.7 39.2 56.3 32.7 3.CA125 4.8 8.3 25.3 45.0 20.4 4.NSE 1.0 5.0 21.5 31.3 14.2 5.SCC 13.3 33.3 31.6 20.0 23.1 6.CYFRA21-1 22.9 48.3 53.2 58.8 43.8 Combined 2~6 47.6 65.0 83.5 86.3 69.1 Combined 1~6 77.1 83.3 97.5 98.8 88.6 Table 4 Tumor marker Sensitivity of and other 5 tumor markers in lung cancer with different stage Sensitivity of and other 5 markers in lung cancer with different pathological types Squamous cell carcinoma Adenocarcinoma Small cell Sarcomatoid carcinoma carcinoma 1. 71.4 68.9 73.1 100.0 2.CEA 20.9 40.4 26.9 14.3 3.CA125 19.8 21.8 15.4 14.3 4.NSE 15.4 7.8 61.5 28.6 5.SCC 44.0 16.1 0 14.3 6.CYFRA21-1 65.9 35.2 26.9 28.6 Combined2~6 82.4 66.3 69.2 42.9 Combined1~6 97.8 84.5 88.5 100.0 [4], SCC,,, SCC, ELISA, SCC, CYFRA21-1 19,, [13],, [11], 5,, (P<0.001), TNM, ROC 0.912, ROC, (~ ), 5 1000pg/ml, ( :66.7% vs 47.6%, : 96.5%71.3% 71.7% vs 65.0%) 6, 77.1% (P=0.022) 83.3%,, (T), (N) (M) ~ (P>0.05), TNM CEA CA125 NSE SCC CYFRA21-1,CEA NSCLC ; CEA [12] CA125 (P<0.01), ;,CA125, 40.18% [12] NSE,,NSE,, NSE, NSE [13], NSE, 5, 424 2015 24 5

[J].,2011,9(4):361-366.] [7] Lee DH,Yang Y,Lee SJ,et al. Macrophage inhibitory cytokine-1 induces the invasiveness of gastric cancer cells, by up-regulating the urokinase-type plasminogen activator : system [J]. Cancer Res,2003,63(15):4648-4655. [8] Welsh JB,Sapinoso LM,Kern SG,et al. Large-scale delineation [1] Groome PA,Bolejack V,Cruwley JJ,et al. The IASLC Lung Cancer Staging Project:validation of the proposals of secreted protein biomarkers overexpressed in cancer tissue and serum [J]. Proc Natl Acad Sci USA, for revision of the T,N,and M descriptors and consequent 2003,100(6):3410-3415. stage groupings in the forthcoming (seventh) edition of the [9] Koopmann J,Buckhaults P,Brown DA,et al. Serum TNM classification of malignant tumours[j]. J Thorac Oncol, macrophage inhibitory cytokine 1 as a marker of pancreatic and other periampullary cancers [J]. Clin Cancer Res, 2007,2(8):694-705. [2] Bauskin AR,Brown DA,Kuffner T,et al. Role of macrophage 2004,10(7):2386-2392. inhibitory cytokine-1 in tumorigenesis and diagnosis of [10] Liang JJ,Kimchi ET,Staveley-O Carroll KF,et al. Diagnostic and prognostic biomarkers in pancreatic carcinoma cancer [J].Cancer Res,2006,66(10):4983-4986. [3] Koopmann J,Rosenzweig CN,Zhang Z,et al. Serum markers in patients with resectable pancreatic adenocarcinoma: [J]. Int J Clin Exp Pathol,2009,2(1):1-10. macrophage inhibitory cytokine 1 versus CA19-9 [J].Clin Cancer Res,2006,12(2):442-446. [11] Fu C. Application and development study of the serum immunoassay kit [D].Beijing:Peking Union Medical [4] Fu C,Wang H,Qi J,et al. Application of serum College,2011. [. macrophage inhibitory cytokine-1 in pancreatic cancer [J]. Oncology Progress,2011,9(2):204-208.[,, [12] [D]. :,2011.] Ma ZH,Shen QB,Fei SW,et al. Significance of combined,. 1 detection of CEA,CA125,CYFRA21-1 and NSE for lung [J].,2011,9(2):204-208.] cancer [J]. Chinese Journal of Immunology,2013,29(11): [5] Kim KK,Lee JJ,Yang Y,et al. Macrophage inhibitory cytokine-1 activates AKT and ERK-1/2 via the transactivation of ErbB2 in human breast and gastric cancer cells[j]. 1174-1176. [,,,. CEA CA125 CYFRA21-1 NSE [J].,2013,29(11):1174-1176.] Carcinogenesis,2008,29(4):704-712. [13] Li YP,Wang Q,Zhao ZH,et al. Diagnostic value of combined [6] Wang XB,Li YF,Tian HM,et al. Development of monoclonal antibody and establishment of detecting system for macrophage inhibitory cytokine-1[j]. Oncology Progress, detection of serum tumor markers for lung cancer [J]. Chin Nucl Med Mol Imaging,2013,33(5):336-339. [,,,. 2011,9(4):361-366. [,,,. -1 2013,33(5):336-339.] [J]., 2015 24 5 425