ΕΜΜΑΝΟΥΗΛ Ν. ΖΟΥΜΑΚΗΣ

BIOΓΡΑΦΙΚΟ ΣΗΜΕΙΩΜΑ (ενηµερώθηκε 2/2013) ΕΜΜΑΝΟΥΗΛ Ν. ΖΟΥΜΑΚΗΣ ιεύθυνση εργασίας: Χωρέµειο Ερευνητικό Εργαστήριο, Νοσοκοµείο Παίδων Αγία Σοφία, 1 η Παιδιατρική Κλινική, Ιατρική Σχολή, Θηβών & Μικράς Ασίας, 11527 Αθήνα Τηλ: +30 210-7794023 Fax: +30 210-7759167 E-mail: zoumakis@bioacademy.gr mzoumak@med.uoa.gr 1988 Πτυχίο Χηµικού Τµήµατος, Πανεπιστήµιο Αθήνας 1989-1991 Στρατιωτική υπηρεσία 1992-1993 Μεταπτυχιακό Ευρωπαϊκό Πρόγραµµα «εκπαίδευση σε υψηλή εργαστηριακή τεχνολογία». Ιατρικό Τµήµα, Πανεπιστήµιο Κρήτης 1998 ιαδάκτορας Ιατρικής, Εργαστήριο Φαρµακολογίας, Τοµέας Βασικών Επιστηµών, Ιατρικό Τµήµα, Πανεπιστήµιο Κρήτης 1998 (Μάρτιος-Απρίλιος) Visiting fellow, Νational Institute of Mental Health, National Institutes of Health, USA 1998-1999 Post-Doctoral fellow, Εργαστήριο Φαρµακολογίας, Τοµέας Βασικών Επιστηµών, Ιατρικό Τµήµα, Παν/µιο Κρήτης 1999-2004 Principal Investigator, Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, USA 2005-2007 Επιστηµονικός συνεργάτης, Χωρέµειο Ερευνητικό Εργαστήριο, Νοσοκοµείο Παίδων Αγία Σοφία, Ιατρική Σχολή, Πανεπιστήµιο Αθήνας 2005- Επιστηµονικός συνεργάτης στο Ιδρυµα Ιατροβιολογικών Ερευνών της Ακαδηµίας Αθηνών (IIBEAA) 2008- Λέκτορας Μοριακής Βιοχηµείας Ιατρική Σχολή, Πανεπιστήµιο Αθήνας 2012- Επίκουρος Καθηγητής, Ιατρική Σχολή, Πανεπιστήµιο Αθήνας Συνοπτικά στοιχεία ερευνητικής σταδιοδροµίας Κεφάλαια σε διεθνή βιβλία: 5 Ξενόγλωσσες δηµοσιεύσεις: 51 Proceedings: 9 ηµοσιεύσεις στα Ελληνικά: 1 Παρουσιάσεις σε διεθνή συνέδρια: 45 Παρουσιάσεις σε Ελληνικά συνέδρια: 6 Βιβλιογραφικοί είκτες Impact Factor: 204,255 (2011 Impact Factor catalog, ISI) Citations Web of Science: Citations 1648 h-index 23 Scopus: Citations 1830 h-index 23 Harzing s: Citations 2807 h-index 24

2 Ερευνητικά Προγράµµατα 4/1993-3/1999 Ιατρικό Τµήµα Πανεπιστηµίου Κρήτης: Ερευνητικό πρόγραµµα ΚΑ340: Μελέτη της έκφραση της έκλυσης και του βιολογικού ρόλου του υποθαλαµικού εκλυτικού παράγοντα της επινεφριδιοτρόπου ορµόνης (CRH) στο ανθρώπινο ενδοµήτριο Ερευνητικό πρόγραµµα ΚΑ469: Αναπτυξιακό πρόγραµµα εφαρµογής κοινονικο-οικονοµικής υποδοµής στη διάγνωση και προφύλαξη του ιού του AIDS και συναφών ρετροϊών Ερευνητικό πρόγραµµα ΚΑ469: Μελέτη της ρύθµισης της σύνθεσης και έκκρισης του ανθρώπινου πλακουντιακού εκλυτικού παράγοντα της κορτικοτροπίνης (CRH) Ερευνητικό πρόγραµµα KA713: Μελέτη της έκφραση στο ενδοµήτριο και της βιολογικής σηµασίας στην εµφύτευση της βλαστοκύστης του υποθαλαµικού εκλυτικού παράγοντα της κορτικοτροπίνης Ερευνητικό πρόγραµµα KA1172: ανάπτυξη νέων µεθόδων θεραπείας και πρόγνωσης των ορµονοεξαρτώµενων νεοπλασιών 6/1999-6/2004 Ερευνητικά προγράµµατα στο Pediatric and Reproductive Endocrinology Branch, National Institute od Child Health and Human Development, National Institutes of Health, Η.Π.Α. 7/2004 σήµερα Ερευνητικά προγράµµατα της Α Παιδιατρικής Κλινικής της Ιατρικής Σχολής του Πανεπιστηµίου Αθηνών Χρηµατοδοτούµενο από Ιατρική Σχολή Πανεπιστηµίου Αθηνών, πρόγραµµα «ΚΑΠΟ ΙΣΤΡΙΑΣ» ΚΕΦΑΛΑΙΑ ΣΕ ΙΕΘΝΗ ΒΙΒΛΙΑ 1. S. Papazacharias, E. Zoumakis, G. Pairas, E. Manessi-Zoupa, P. Sotiriou, A. Gravanis and P. Cordopatis (2000). Solid Phase Synthesis and Some Biological Properties of h/rcrf". In "Solid Phase Synthesis and Combinatorial Chemical Libraries" (R. Epton, Ed.), Mayflower, Wordwide Ltd., Kingswinford, 86, 333-336 2. G. P. Chrousos, E. Zoumakis, A. Gravanis A. (2000) The gonadal hormones and inhibitors. In "Basic & Clinical Pharmacology", 8 th eddition, Bertram G. Katzung (ed), Lange, McGraw- Hill Companies, New York (publs), 679-710 3. Dewleen G. Baker, Thomas D. Geracioti, Jr, John W. Kasckow, Emmanouil Zoumakis, George P. Chrousos. (2001). Cytokines and post-traumatic stress disorder. In "Cytokines and Mental Health", Ziad Kronfol (ed), Kluwer Academic Publishers. 4. Emmanouil Zoumakis, Ilia Elenkov and George P. Chrousos. (2004). Hypothalamicpituitary-adrenal AXIS. Effects on innate and adaptive immunity. In Neuroimmunoendocrinology Markel Dekker Inc. Chapter 3/5060-8 5. S. Kalantaridou, A. Makrigiannakis, E. Zoumakis and GP. Chrousos. (2004). The role of Corticotropin-Releasing Hormone (CRH) on implantation and immunotolerence of the fetus. In Immunology of Pregnancy Gil Mor (ed), Landes Bioscience/Eurekah.com. ΞΕΝΟΓΛΩΣΣΕΣ ΗΜΟΣΙΕΥΣΕΙΣ

3 1. Zoumakis E * /Makrigiannakis A *, Margioris A, Theodoropoulos P, Stournaras C, Gravanis A. (1995). The corticotropin-releasing hormone (CRH) in normal and tumoral epithelial cells of human endometrium. J Clin Endocrinol Metab 80:185-189. ( * equally contributed) Αναφορές 67 2. Makrigiannakis A, Margioris AN, Le Goascogne C, Zoumakis E, Nikas G, Stournaras C, Psychoyos A, Gravanis A. (1995). Corticotropin-releasing hormone (CRH) is expressed at the implantation sites of the early pregnant rat uterus. Life Sci. 57:1869-75. Αναφορές 59 Impact Factor: 2,451 3. Hatzoglou A, Gravanis A, Margioris A, Zoumakis E, Castanas E. (1995). Identification and characterization of opioid binding sites present in the Ishikawa human endometrial adenocarcinoma cell line. J Clin Endocrinol Metab, 80:418-423. Αναφορές 17 4. Zoumakis E, Makrigiannakis A, Margioris AN, Stournaras C, Gravanis A. (1996). Corticotropin-releasing hormone (CRH) in normal and pregnant uterus: physiological implications. Frontiers in Bioscience Vol 1: E1-8. Αναφορές 9 Impact Factor: 4,048 5. Makrigiannakis A, Zoumakis E, Margioris AN, Stournaras C, Chrousos GP, Gravanis A. (1996). Regulation of the promoter of the human Corticotropin-releasing hormone gene in transfected human endometrial cells. Neuroendocrinology 64:85-92. Αναφορές 48 Impact Factor: 3,272 6. E. Zoumakis, A.N. Margioris, A Makrigiannakis, C. Stournaras, A. Gravanis. (1997). Human endometrium as a neuroendocrine tissue: Expression, regulation and biological roles of endometrial corticotropin-releasing hormone (CRH) and opioid peptides. J Endocrinol Invest 20:158-167. Αναφορές 12 Impact Factor: 1,476 7. Makrigiannakis A, Psychoyos A, Zoumakis E, Margioris AN, Stournaras C, Gravanis A. (1997). Endometrial Corticotropin-releasing hormone (CRH): expression, regulation and potential physiological implications. Ann N Y Acad Sci. 816:116-128. Αναφορές 11 Impact Factor: 2,847 8. Markogiannakis E, Georgoulias V, Margioris A, Zoumakis E, Stournaras C, Gravanis A. (1997). Estrogen and glucocorticoids induce the expression of erbb2/neu receptor in Ishikawa human endometrial adenocarcinoma cells. Life Sci. 61:1083-1095. Αναφορές 16 Impact Factor: 2,451

4 9. E. Zoumakis, A Makrigiannakis, A.N. Margioris, C. Stournaras, A. Gravanis. (1997). Endometrial corticotropin-releasing hormone (CRH): its potential autocrine-paracrine actions. Ann NY Acad Sci. 828:84-94. Αναφορές 16 Impact Factor: 2,847 10. Makrigiannakis A, Margioris A, Chatzaki Α, Zoumakis E, Chrousos G, Gravanis A. (1999). The decidualizing effect of progesterone may involve direct transcriptional activation of corticotropin-releasing hormone (CRH) from human endometrial stroma cells. Mol Hum Reprod. 5:789-96. Αναφορές 28 Impact Factor: 3,506 11. Makrigiannakis A, Margioris A, Zoumakis E, Stournaras C, Gravanis A. (1999). The transcription of corticotropin-releasing hormone in human endometrial cells is regulated by cytokines. Neuroendocrinology 70:451-9 Αναφορές 30 Impact Factor: 3,272 12. Zoumakis E, Margioris AN, Stournaras C, Dermitzaki E, Angelakis E, Makrigiannakis A, Koumantakis E, Gravanis A. (2000). Corticotrophin-releasing hormone (CRH) interacts with inflammatory prostaglandins and interleukins and affects the decidualization of human endometrial stroma. Mol Hum Reprod 6:344-51 Αναφορές 53 Impact Factor: 3,506 13. Gravanis A, Makrigiannakis A, Zoumakis E, Margioris A. (2001). Endometrial and myometrial Corticotropin-Releasing Hormone (CRH): its regulation and possible roles. Peptides 22:785-93 Αναφορές 14 Impact Factor: 2,654 14. E. Zoumakis, E. Chatzaki, I. Charalampopoulos, A.N. Margioris, E. Angelakis, E. Koumantakis, A. Gravanis. (2001). Cycle and age related changes in corticotropin-releasing hormone levels in human endometrium and ovaries. Gynecol Endocrinol 15:98-102 Αναφορές 24 Impact Factor: 1,461 15. A. Makrigiannakis, E. Zoumakis, S. Kalantaridou, C. Coutifaris, A. N. Margioris, G. Coukos, K. C. Rice, A. Gravanis, G. Chrousos. (2001). Corticotropin-releasing Hormone (CRH) promotes blastocyst implantation and maternal tolerance. Nature Immunology 2:1018-24 Αναφορές 114 Impact Factor: 25,668 16. D. Baker, N. Ekhator, J. Kasckow, K. Hill, E. Zoumakis, B. Dashevsky, G. P. Chrousos and T. Geracioti, Jr. (2001). Plasma and cerebrospinal fluid interleukin-6 concentrations in posttraumatic stress disorder. Neuroimmunomodulation. 9(4):209-17 Αναφορές 68 Impact Factor: 2,642

5 17. A Gravanis, A Makrigiannakis, E Chatzaki, E Zoumakis, C Tsatsanis, AN Margioris (2002). Stress neuropeptides in the human endometrium: Paracrine effects on cell differentiation and apoptosis. Hormones 1:139-148 Αναφορές Impact Factor: 2,097 18. A.N. Vgontzas, M. Zoumakis, D.A. Papanicolaou, E.O. Bixler, P. Prolo, H.M. Lin, A. Vela-Bueno, A. Kales, G.P. Chrousos. (2002). Chronic insomnia is associated with a shift of interleukin-6 and tumor necrosis factor secretion from nighttime to daytime. Metabolism. 51(7):887-92 Αναφορές 91 Impact Factor: 2,538 19. M. Friedberg, E. Zoumakis, N. Hiroi, T. Bader, G.P. Chrousos and Z. Hochberg. (2003). Modulation of 11-hydroxysteroid dehydrogenase type 1 in mature human subcutaneous adipocytes by hypothalamic messengers. J Clin Endocrinol Metab 88:385-393 Αναφορές 43 20. A. Makrigiannakis, E. Zoumakis, S. Kalantaridou, N. Mitsiades, A. Margioris, G. Chrousos, A. Gravanis. (2003). Corticotropin-releasing hormone (CRH) and immunotolerance of the fetus. Biochem Pharmacol. 51(7):887-92 Αναφορές 18 Impact Factor: 4,889 21. T. Bader, E. Zoumakis, M. Friedberg, G.P. Chrousos, Z. Hochberg (2003). Human adipose tissue under in vitro inhibition of 11β-Hydroxysteroid Dehydrogenase type 1: differentiation and metabolism changes. Horm Metab Res. 34:752-757 Αναφορές 9 Impact Factor: 2,414 22. A. Vgontzas, M. Zoumakis, E. Bixler, H Lin, P Prolo, A Vela-Bueno, A Kales, G Chousos (2003). Impaired nighttime sleep in healthy old vs. young adults is associated with elevated plasma IL-6 and cortisol levels: physiologic and therapeutic implications. J Clin Endocrinol Metab. 88:2087-95 Αναφορές 86 23. A. Makrigiannakis, E Zoumakis, S. Kalantaridou, G. Chrousos and A. Gravanis. (2003). Uterine and embryonic trophoblast CRH promotes implantation and maintenance of early pregnancy. Ann N Y Acad Sci. 997:85-92 Αναφορές 3 Impact Factor: 2,847 24. Vgontzas AN, Zoumakis E, Bixler EO, Lin HM, Follett H, Kales A, Chrousos GP. (2004). Adverse effects of modest sleep restriction on sleepiness, performance, and inflammatory cytokines. J Clin Endocrinol Metab. 89:2119-26. Αναφορές 216

6 25. Kalantaridou SN, Makrigiannakis A, Zoumakis E, Chrousos GP. (2004). Reproductive Functions of Corticotropin-Releasing Hormone. Research and Potential Clinical Utility of Antalarmins (CRH Receptor Type 1 Antagonists). Am J Reprod Immunol. 51:269-74 Αναφορές 18 Impact Factor: 2,451 26. Kalantaridou SN, Makrigiannakis A, Zoumakis E, Chrousos GP. (2004). Stress and the female reproductive system. J Reprod Immunol. 62:61-8 Αναφορές 57 Impact Factor: 2,204 27. Makrigiannakis A, Zoumakis E, Kalantaridou SN, Chrousos GP. (2004). Endometrial and placental CRH as regulators of human embryo implantation. J Reprod Immunol. 62:53-9 Αναφορές 8 Impact Factor: 2,204 28. A Vgontzas, E Zoumakis, HM. Lin, EO Bixler, G Trakada, GP Chrousos. (2004). Marked Decrease in Sleepiness in Patients with Sleep Apnea by Etanercept, a Tumor Necrosis Factor- {alpha} Antagonist. J Clin Endocrinol Metab. 89:4409-13 Αναφορές 130 29. O Fruchter, T. Kino, E Zoumakis, S. Alesci, M. De Martino, G Chrousos, Z Hochberg. (2005). The human glucocorticoid receptor (GR) isoform β differentially suppresses Grαinduced transactivation stimulated by synthetic glucocorticoids. J Clin Endocrinol Metab. 90:3505-9 Αναφορές 22 30. S Krishnamoorthy, T Bei, E Zoumakis, GP Chrousos and A Iliadis. (2006). Morphological and binding properties of interleukin-6 on thin ZnO films grown on (100) silicon substrates for biosensor applications. Biosens Bioelectron. 22:707-14 Αναφορές 25 Impact Factor: 5,361 31. Vgontzas AN, Trakada G, Bixler EO, Lin HM, Pejovic S, Zoumakis E, Chrousos GP, Legro RS. (2006). Plasma interleukin 6 levels are elevated in polycystic ovary syndrome independently of obesity or sleep apnea. Metabolism. 55:1076-82 Αναφορές 42 Impact Factor: 2,538 32. Vgontzas AN, Pejovic S, Zoumakis E, Lin HM, Bixler EO, Basta M, Fang J, Sarrigiannidis A, Chrousos GP. (2006). Daytime napping after a night of sleep loss decreases sleepiness, improves performance, and causes beneficial changes in cortisol and Interleukin-6 secretion. Am J Physiol Endocrinol Metab. 292:E253-261 Αναφορές 28 Impact Factor: 4,686 33. O Fruchter, E Zoumakis, M DeMartino, S Alesci, G Chrousos, Z Hochberg. (2006). Intracrive modulation of gene expression by intracellular generation of active glucocorticoids. Steroids. 71:1001-6 Αναφορές 6

7 Impact Factor: 3,106 34. E Chatzaki, V Minas, E Zoumakis, A Makrigiannakis. (2006). CRF receptor antagonists. Utility in research and clinical practice. Curr Med Chem. 13:2751-60 Αναφορές 9 Impact Factor: 4,630 35. E Zoumakis, DK Grammatopoulos and GP Chrousos. (2006). Corticotropin-releasing hormone receptor antagonists. Eur J Endocrinol. 155:S85-S91 Αναφορές 7 Impact Factor: 3,482 36. Kalantaridou SN, Makrigiannakis A, Zoumakis E, Chrousos GP. (2007). Peripheral corticotropin-releasing hormone is produced in the immune and reproductive systems: actions, potential roles and clinical implications. Front Biosci. 12:572-80 Αναφορές 11 Impact Factor: 4,048 37. E. Zoumakis, KC Rice, PW Gold and GP Chrousos. (2007). Potential uses of Corticotropin-releasing hormone (CRH) antagonists. Ann N Y Acad Sci. 1083:239-51 Αναφορές 24 Impact Factor: 2,847 38. S. Kalantaridou, E. Zoumakis, A. Makrigiannakis, H. Godoy, G. P. Chrousos. (2007). The role of corticotropin-releasing hormone in blastocyst implantation and early fetal immunotolerance. Horm Metab Res. 39:474-477 Αναφορές 10 Impact Factor: 2,414 39. Vgontzas AN, Pejovic S, Zoumakis E, Lin HM, Bentley CM, Bixler EO, Sarrigiannidis A, Basta M, Chrousos GP. (2007). Hypothalamic-pituitary adrenal axis activity in obese men with and without sleep apnea: Effects of continuous positive airway pressure therapy. J Clin Endocrinol Metab. 92:4199-4207 Αναφορές 31 40. SN Kalantaridou, E Zoumakis, S Weil, LG Lavasidis, GP Chrousos, A Makrigiannakis. (2007) Reproductive corticotropin-releasing hormone, implantation and fetal immunotolerance. Crit Rev Clin Lab Sci. 44:461-481 Αναφορές 6 Impact Factor: 5,741 41. E Zoumakis, SN Kalantaridou, GP Chrousos. (2007) Editorial. The Brain-Skin Connection : Nerve Growth Factor-dependent Pathways for Stress-Induced Skin Disorders. J Mol Med. 85:1347-1349 Αναφορές 1 Impact Factor: 5,192 42. M G Pavlatou, G Mastorakos, I Lekakis, S Liatis, Z Vamvakou, E Zoumakis, I Papassotiriou, A D Rabavilas, N Katsilambros and G P Chrousos. (2008) Chronic Administration of an Angiotensin II Receptor Antagonist Resets the Hypothalamic-pituitaryadrenal (HPA) Axis and Improves the Affect of Patients with Impaired Glucose Tolerance

8 and/or Diabetes Mellitus Type 2: A Pilot Study. Stress. 11(1):62-72. Αναφορές 8 Impact Factor: 2,553 43. Vgontzas AN, Zoumakis E, Bixler EO, Lin HM, Collins B, Basta M, Pejovic S, Chrousos GP. (2008) Selective effects of CPAP on sleep apnoea-associated manifestations. Eur J Clin Invest. 38(8):585-95 Αναφορές 28 Impact Factor: 3,482 44. Lambrou GI, Vlahopoulos S, Papathanasiou C, Papanikolaou M, Karpusas M, Zoumakis E, Tzortzatou-Stathopoulou F. (2009) Prednisolone exerts late mitogenic and biphasic effects on resistant acute lymphoblastic leukemia cells: Relation to early gene expression. Leuk Res. 33(12):1684-95. Αναφορές 6 Impact Factor: 2,555 45. Bratis D, Tselebis A, Sikaras C, Moulou A, Giotakis K, Zoumakis E, Ilias I. (2009) Alexithymia and its association with burnout, depression and family support among Greek nursing staff. Hum Resour Health. 7:72 Αναφορές 5 Impact Factor: 46. Karalis, K, Giannogonas P, Kodela E, Koutmani Y, Zoumakis, M. Teli T. (2009) Mechanisms of obesity and related pathology: linking immune responses to metabolic stress. FEBS J. 276(20):5747-54 Αναφορές 39 Impact Factor: 3,129 47. E Zoumakis, SN Kalantaridou, A Makrigiannakis. (2009) CRH-like peptides in human reproduction. Curr Med Chem. 16(32):4230-5 Αναφορές 4 Impact Factor: 4,630 48. E. Zoumakis, G. P. Chrousos. (2010) Corticotropin-releasing hormone receptor antagonists: an update. Endocrine Dev. 17:36-43 Αναφορές 2 Impact Factor: 49. S.N. Kalantaridou, E. Zoumakis, A. Makrigiannakis, L.G. Lavasidis, T. Vrekoussis, G.P. Chrousos. (2010) Corticotropin-Releasing Hormone, Stress and Human Reproduction: an update. J Reprod Immunol. 85:33-39 Αναφορές 10 Impact Factor: 2,204 50. S Pejovic, AN. Vgontzas, M Basta, M Tsaoussoglou1, E Zoumakis, A Vgontzas, EO. Bixler, GP. Chrousos. (2010) Leptin and hunger levels in young healthy adults after one night of sleep loss. J Sleep Res. 2010 19:552-8 Αναφορές 10 Impact Factor: 3,361

9 51. T Vrekoussis, SN Kalantaridou, G Mastorakos, E Zoumakis, A Makrigiannakis, M Syrrou, LG Lavasidis, K Relakis, GP Chrousos. (2010) The role of stress in female reproduction and pregnancy: An Update. Ann N Y Acad Sci. 1205(1):69-75 Αναφορές 3 Impact Factor: 2,847 52. A Krikri, V Alexopoulos, E Zoumakis, P Katsaronis, E Balafas, G Kouraklis, PE Karayannacos, GP Chrousos, G Skalkeas. (2012) Marked Differences in Cortisol and Catecholamine Responses in Laparoscopic vs. Open Abdominal Surgery Endocrinology In preparation PROCEEDINGS 1. Vgontzas AN; Papanicolaou DA; Zoumakis M; Bixler EO; Prolo P; Lin HM; Vela-Bueno A; Kales A; Chrousos GP. Insomnia is associated with altered circadian interleukin-6 and TNF alpha secretion. SLEEP 2001, Vol 24, pp 600 2. Vgontzas AN; Zoumakis M; Bixler EO; Chrousos GP; Lin HM. Continuous positive airway pressure does not reverse hypercortisolism, hypercytokinemia, or insulin resistance associated with sleep apnea. SLEEP 2003, Vol 26, pp A229-A229 3. Mahadevan V; Morrison K; Wilson M; Souto-Carneiro MM; Brown M; Zoumakis E; Lipsky PE; Goldbach-Mansky RT. Alterations in peripheral blood memory B-cells in rheumatoid arthritis patients: Correction with anti TNF therapy and correlation with serum interleukin-6. ARTHRITIS AND RHEUMATISM 2003, Vol 48, Iss 12, pp 3618-3618 4. Vgontzas A; Trakada G; Bixler E; Lin H; Zoumakis E; Chrousos G; Legro R. Plasma IL-6 and TNF alpha levels are elevated in polycystic ovary syndrome independent of obesity and sleep disturbance. SLEEP 2004, Vol 27, pp 334 5. Vgontzas A; Zoumakis E; Lin H; Bixler E; Vela AB; Chrousos G. Marked decrease of sleepiness in patients with sleep apnea by etanercept. SLEEP 2004, Vol 27, pp 215 6. M Pavlatou, G Mastorakos, I Lekakis, S Liatis, Z Vamvakou, E Zoumakis, I Papassotiriou, A D Rabavilas, N Katsilambros, GP Chrousos. Chronic administration of an angiotensin II receptor antagonist resets the hypothalamic-pituitary-adrenal axis and improves the affect of patients with impaired glucose tolerance and/or diabetes mellitus type 2: a pilot study. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 37: 69-70 210 Suppl. 1, MAY 2007 7. Vgontzas AN, Zoumakis E, Bixler EO, Chrousos GP. Leptin levels in young healthy men and women are increased after one night of sleep loss in a non-stressful environment. SLEEP 2009, Vol 32, pp A159 Abstract 480 8. Papaefthymiou M, Zoumakis E, Voskaki E, Sertedaki, A, Bakoula C, Chrousos G. The relationship between LH, FSH, IGF-1 and bone mineral density in Greek adolescent men. OSTEOPOROSIS INTERNATIONAL Volume: 22 Pages: 308-308 Suppl. 1 Published: MAR 2011 9. E Zoumakis, A Krikri, V Alexopoulos, P Katsaronis, E Balafas, G Kouraklis, P E Karayannacos, G P Chrousos, and G Skalkeas. Laparoscopic vs. Open Abdominal Surgery:

10 Marked Differences in Cortisol and Catecholamine Responses Dependent on Size and Severity of Abdominal Wall Trauma Endocr Rev 32: P3-574 June 2011 ΗΜΟΣΙΕΥΣΕΙΣ ΣΕ ΕΛΛΗΝΙΚΑ ΠΕΡΙΟ ΙΚΑ Γ.Π. Χρούσος, Ε. Ζουµάκης. Βιβλιογραφική αξιολόγηση ερευνητικού έργου θετικών επιστηµόνων. ελτίο A' Παιδιατρικής Kλινικής Πανεπιστηµίου Aθηνών. Tόµος 56 Τεύχος 3 Ιούλιος-Αύγουστος-Σεπτέµβριος 2009 Παρουσιάσεις σε ΙΕΘΝΗ ΣΥΝΕ ΡΙΑ 1. Makrigiannakis A, Zoumakis E, Markogiannakis E, Theodoropoulos P, Stournaras C, Margioris A, Gravanis A. The Corticotropin-Releasing Hormone is expressed in Ishikawa human endometrial cells. Abstract in 75 th Endocrine Meeting, Las Vegas, ND, USA, 1993 2. Zoumakis E, Margioris A. N, Makrigiannakis A, Stournaras C, Gravanis A. (1994). The corticotropin releasing hormone (CRH) gene is expressed in normal and tumoral epithelial cells of human endometrium. 9 th European Congress of Endocrinology, Amsterdam, Holland, 1994 3. Makrigiannakis A, Margioris AN, Zoumakis E, Le Goascogne C, Nikas G, Stournaras C, Psychoyos A, Gravanis A. (1995). The corticotropin-releasing hormone (CRH) is expressed at the implantation sites of the early pregnant rat uterus. 77 th Endocrine Society Meeting, Washington USA, 1995 4. Makrigiannakis A, Zoumakis E, Margioris AN, Stournaras C, Chrousos GP, Gravanis A. Estrogen and glucocorticoids repress the activity of the 5'-flanking region of human corticotropin-releasing hormone gene in transiently transfected Ishikawa human endometrial cells. 77 th Endocrine Society Meeting, Washington USA, 1995 5. Markogiannakis E, Georgoulias V, Zoumakis E, Stournaras C, Gravanis A. Steroid hormones regulate the expression of erbb2 oncogene in endometrial adenocarcinoma cells. FEBS 96 Meeting, Barcelona, Spain, 1996 6. Makrigiannakis A, Zoumakis E, Gravanis A. Steroid hormone and cytokine effects on the promoter of endometrial CRH gene: potential implications in early pregnancy. 3 th International Conference " The Endometrium", New York, USA 1996 7. Zoumakis E, Margioris A. N, Makrigiannakis A, Dermitzaki I, Fraidakis M, Gravanis A. (1997). Paracrine effects of endometrial corticotropin-releasing hormone (CRH) on human endometrial stromal cell differentation. 8 th Meeting of the European Neuroendocrine Association, S8-7, 1S67, September 1997, Marseille-France 8. Zoumakis E, Margioris A, Dermitzaki I, Gravanis A. Corticotropin releasing hormone (CRH) regulates the release of prostaglandin E2 (PGE2) and interleukin-6 (IL-6) from human endometrial stromal cells in culture. 14 th European Congress of Endocrinology, Sevilla, Spain 1998 9. Makrigiannakis A, Chatzaki E, Zoumakis E, Margioris A, Chrousos G, Gravanis A. Progestins stimulate the activity of the 5 -flanking region of corticotropin releasing hormone (CRH) gene in transfected stromal cells of human endometrium: evidence for the necessity of the camp response element. 80 th American Endocrine Society Meeting, New Olreans, USA 1998 10. Zoumakis E, Dermitzaki I, Margioris A, Makrigiannakis A, Gravanis A. Cross-talk between endometrial corticotropin-releasing hormone (CRH) and prostaglandin E2 (PGE2) to control endometrial stroma differentiation. 80 th American Endocrine Society Meeting, New Orleans, USA 1998

11 11. E. Zoumakis, N. Mitsiades, A. Makrigiannakis, S. Kalantaridou, G. P. Chrousos. Progesterone stimulates secretion of CRH and expression of FasL by first trimester human placenta cells. 82 nd American Endocrine Society Meeting, Toronto, Canada 2000 12. DG. Baker, NN. Ekhator, JW. Kasckow, KK. Hill, E. Zoumakis, BA. Dashevsky, GP. Chrousos and TD. Geracioti, Jr. Plasma and cerebrospinal fluid interleukin-6 concentrations in combat veterans with posttraumatic stress disorder. "Cytokine and the Brain" pre-conference meeting. New Orleans, USA 2000 13. M. Friedberg, E. Zoumakis, G. Chrousos and Z. Hochberg. Modulation of 11βhydroxysteroid dehydrogenase type 1 (11-HSD-1) in S.C. adipose tissue by stress-related factors. 83 rd American Endocrine Society Meeting, Denver, USA 2001 14. A Vgontzas, E Zoumakis, EO Bixler, H Lin, A Kales, GP Chrousos. The interaction of IL-6 hypersecretion and hypercortisolemia is associated with sleep disturbances in older adults. 83 rd American Endocrine Society Meeting, Denver, USA 2001 15. V Vicennati, A Vottero, E Zoumakis, U Pagotto, R Pasquali, DA Papanicolaou. Direct effects of corticotropin-releasing hormone on cultured human adipocytes. 83 rd American Endocrine Society Meeting, Denver, USA 2001 16. A.N. Vgontzas, E. Zoumakis, E.O. Bixler, H. Lin, A. Kales, and G.P. Chrousos. Agerelated changes in nighttime sleep and daytime sleep propensity are associated with elevated cortisol and IL-6 levels in healthy adults. 16 th Congress of the European sleep research society. Reykjavik, June 3-7, Iceland 2002 17. A.N. Vgontzas, E. Zoumakis, E.O. Bixler, H. Lin, K. Hopper, A. Kales, and G.P. Chrousos. Age-related changes of IL-6 and relation with visceral fat in healthy adults. 16 th Congress of the European sleep research society. Reykjavik, June 3-7, Iceland 2002 18. T Bader, E Zoumakis, N Hiroi, M Friedberg, G P Chrousos and Z Hochberg. Competitive subcutaneous and omental inhibition of 11b-hydroxysteroid dehydrogenase type 1 (11-HSD-1) in human adipose tissue. 84 th American Endocrine Society Meeting, San Francisco, CA, USA 2002 19. E Zoumakis, A Makrigiannakis and G P Chrousos. Decidual CRH upregulates its own production acting in an autocrine fashion to promote maternal immune tolerance to the fetus. 84 th American Endocrine Society Meeting, San Francisco, CA, USA 2002 20. D Baker, N Ekhator, E Zoumakis, B Dashevsky, G P Chrousos and T Geracioti. Cerebrospinal Fluid (CSF) Interleukin-8 Concentration: Correlation with Age and CSF Norepinephrine Levels. 84 th American Endocrine Society Meeting, San Francisco, CA, USA 2002 21. A Vgontzas, E Zoumakis, E Bixler, H-M Lin, G P Chrousos. Effects of one week of modest sleep restriction to 6 hours per night on daytime sleepiness and performance and IL-6, TNF and cortisol plasma levels. 84 th American Endocrine Society Meeting, San Francisco, CA, USA 2002 22. AN Vgontzas, M Zoumakis, EO Bixler, H-M Lin, GP Chrousos. Continuous positive airway pressure does not reverse hypercortisolism, hypercytokinemia, or insulin resistance associated with aleep apnea. APSS 17th Annual Meeting, Chicago, XX, IL, USA 2003 23. Mahadevan V, Morrison K, Wilson M, Souto-Carneiro MM, Brown M, Zoumakis E, Lipsky PE, Goldbach-Mansky RT. Alterations in peripheral blood memory B-cells in rheumatoid arthritis patients: Correction with anti TNF therapy and correlation with serum interleukin-6. Arthritis and Rheumatism 48 (12): 3618-3618 DEC 2003 24. O Fruchter, E Zoumakis, S Alesci, M DeMartino, G Chrousos, Z Hochberg. Comparative transcriptional activity of glucocorticoids (GC) in a human liver cell line. 42nd European Society for Pediatric Endocrinology Meeting, Ljubljana, Slovenia September, 2003 25. O Fruchter, E Zoumakis, S Alesci, M DeMartino, G Chrousos, Z Hochberg. Intracrive modulation: a novel aspect of gene expression regulation by intracellular generation of active glucocorticoids. 42nd European Society for Pediatric Endocrinology Meeting, Ljubljana, Slovenia September, 2003

12 26. H. White, J. Beecham, M. Zoumakis, G. Chrousos and K. Roby. A Mechanism by which ovarian carcinoma cells neutralize CD8+ T lymphocytes at the tumor site. Meeting of the New England Association of Gynecologic Oncologists, Maine, June 2003 27. O Fuchter, T. Kino, E Zoumakis, S. Alesci, M. De Martino, G Chrousos, Z Hochberg. The human glucocorticoid receptor (GR) isoform differentially suppresses Gr beta-induced transactivation stimulated by synthetic glucocorticoids. The Annual Meeting of the Israeli Endocrine Society, Tel Aviv, Israel, 2003 28. S Alesci, E Zoumakis, I Manoli, A R Ayala, P W Gold, G P Chrousos, M R Blackman. L-Carnitine Stimulates Leptin and Adiponectin Release from Primary Cultures of Human Subcutaneous Adipocytes. 85 th American Endocrine Society Meeting, Philadelphia, PA, USA 2003 29. A N Vgontzas, E Zoumakis, E O Bixler, H Lin, H Follett, G P Chrousos. Healthy Young Women Compared to Men Are More Resilient to Sleep Loss and Sleep Disturbance Than Age-Matched Men: Potential Protective Role of Estrogen. 85 th American Endocrine Society Meeting, Philadelphia, PA, USA 2003 30. E. Zoumakis and G.P. Chrousos. Administration of Antalarmin improves fertility rates in Fischer (F344/N) rats. 11 th World Congress of Gynecological Endocrinology, Florence, Italy, February 2004 31. AN Vgontzas, M Zoumakis, EO Bixler, H-M Lin, B Pejovic, GP Chrousos. Twentyfour Hour Secretion of Leptin and Adiponectin in Patients with Obstructive Sleep Apnea and Obese Controls. 86 th American Endocrine Society Meeting, New Orleans, LA, USA 2004 32. AN Vgontzas, M Zoumakis, EO Bixler, H-M Lin, M. Basta, GP Chrousos. Continuous Positive Airway Pressure Does Not Improve Low-grade Inflammation or Insulin Sensitivity in Sleep Apnea. 86 th American Endocrine Society Meeting, New Orleans, LA, USA 2004 33. N. Vgontzas, E. Zoumakis, E. O. Bixler, H. -M. Lin, M. Basta, G. P. Chrousos. Continuous positive airway pressure does not improve insulin sensitivity or visceral adiposity in sleep apnea. 17th Congress of the European Sleep Research Society, Czech Rebublic, Prague, October 2004. 34. E. Zoumakis and GP. Chrousos. Administration of Antalarmin improves fertility rates in the anxious Fischer (F344/N) rats characterized by increased hypothalamic CRH secretion: Another potential application of CRH Receptor type 1 antagonists. 87 th American Endocrine Society Meeting, San Diego, CA, USA 2005 35. AN Vgontzas, S Pejovic, E Zoumakis, H-M Lin, EO Bixler, M Basta, GP Chrousos. Daytime napping following one night of sleep loss restores alertness and cortisol secretion and decreases post-nap IL-6 levels: roles of cortisol and IL-6 respectively as arousal and sleep and sleepiness factors in humans. 87 th American Endocrine Society Meeting, San Diego, CA, USA 2005 36. AN Vgontzas, S Pejovic, H-M Lin, E Zoumakis, EO Bixler, S Galhoun, G Trakada, GP Chrousos. In the quiet and acclimatized state of a sleep laboratory, obesity is associated with decreased Hypothalamic-Pituitary-Adrenal (HPA) axis activity consistent with the hypoarousal and daytime sleepiness and fatigue of abese patiens: role of sleep apnea and CPAP therapy. 87 th American Endocrine Society Meeting, San Diego, CA, USA 2005 37. E. Zoumakis. Progesterone stimulates secretion of Corticotropin-Releasing Hormone from human extravillous trophoblast cells. 39 th Annual Scientific Meeting of ESCI, Athens, Greece, 6 9 April 2005 38. E. Zoumakis. Antalarmins. 6th Meeting of the Internations Society for NeuroImmunoModucation. September 25-28, Athens 2005 39. M Pavlatou, G Mastorakos, I Lekakis, S Liatis, Z Vamvakou, E Zoumakis, N Katsilambros, GP Chrousos. Angiotensin 2 receptor antagonist therapy suppresses hypothalamic-pituitary-adrenal (HPA) axis function in patients with impaired glucose tolerance and diabetes mellitus type II. 88 th American Endocrine Society Meeting, Boston, MA, USA, 2006

13 40. A N Vgontzas, S Pejovic, E Zoumakis, Hung-Mo Lin, C M Bentley, E O Bixler, A Sarrigiannidis, M Basta, G P Chrousos. In Nondepressed, Obese Men, Hypothalamic- Pituitary-Adrenal (HPA) Axis Activity Is Decreased: Evidence from the Ovine CRH Test. 88 th American Endocrine Society Meeting, Boston, MA, USA, 2006 41. S Pejovic, E Zoumakis, A Sarrigiannidis, M N Papaliaga, E O Bixler, G P Chrousos, A N Vgontzas. Influence of One Night of Sleep Loss on Leptin, Adiponectin, and Hunger in Young, Healthy Men and Women. 88 th American Endocrine Society Meeting, Boston, MA, USA, 2006 42. Vgontzas AN, Zoumakis E, Bixler EO, Chrousos GP. Leptin levels in young healthy men and women are increased after one night of sleep loss in a non-stressful environment. 23 rd Annual Meeting of the Associated Proffesional Sleep Societies, Seattle, WA, USA, 2009 43. E Zoumakis, SN Kalantaridou, A Makrigiannakis, GP Chrousos. CRH in Human Reproduction. 7 th Europen Congress on Reproductive Immunology, Marathon, Greece, September 2009 44. Papaefthymiou M, Zoumakis E, Voskaki E, Sertedaki, A, Bakoula C, Chrousos G. The relationship between LH, FSH, IGF-1 and bone mineral density in Greek adolescent men. European Congress on Osteoporosis & Osteoarthritis, March 23-26, Valencia, Spain, 2011 45. E Zoumakis, A Krikri, V Alexopoulos, P Katsaronis, E Balafas, G Kouraklis, PE Karayannacos, GP Chrousos, G Skalkeas. Laparoscopic vs. Open Abdominal Surgery: Marked Differences in Cortisol and Catecholamine Responses Dependent on Size and Severity of Abdominal Wall Trauma. 93 rd American Endocrine Society Meeting, Boston, MA, USA, June 2011 Παρουσιάσεις σε ΕΛΛΗΝΙΚΑ ΣΥΝΕ ΡΙΑ 1. A Μακρυγιαννάκης, Ε. Ζουµάκης, Α. Γραβάνης. Μελέτη της έκφρασης και της ρύθµισης του γονιδίου του υποθαλαµικού εκλυτικού παράγοντα της επινεφριδιοτρόπου ορµόνης (CRH) στα ανθρώπινα ενδοµητρικά κύτταρα. 6ο Πανελλήνιο συνέδριο Μαιευτικής και Γυναικολογίας, Αθήνα 1994 2. A Μακρυγιαννάκης, Ε. Ζουµάκης, Α. Μαργιωρής, Π. Θεοδωρόπουλος, Χ. Στουρνάρας & Α. Γραβάνης. Το γονίδιο του υποθαλαµικού εκλυτικού παράγοντα έκλυσης της κορτικοτροπίνης (CRH) εκφράζεται στα φυσιολογικά και καρκινικά κύτταρα του ανθρώπινου ενδοµητρίου. 41η Επιστηµονική συνεδρία, Ελληνική Βιοχηµική και Βιοφυσική Εταιρεία. 1994. 3. Μακρυγιαννάκης, Α. Μαργιωρής, Ε. Ζουµάκης, Χ. Στουρνάρας, Α. Γραβάνης. Αυξηµένη έκφραση του γονιδίου του υποθαλαµικού εκλυτικού παράγοντα της κορτικοτροπίνης στις θέσεις εµφύτευσης της βλαστοκύστης στη µήτρα του επίµυος. 42η Επιστηµονική συνεδρία, Ελληνική Βιοχηµική και Βιοφυσική Εταιρεία. 1995. 4. Μακρυγιαννάκης, Α. Μαργιωρής, Ε. Ζουµάκης, Χ. Στουρνάρας, Α. Γραβάνης. Κατασταλτική δράση των οιστρογόνων και γλυκοκορτικοειδοστεροειδών ορµονών στη δραστικότητα της 5'- προαγωγού (promoter) περιοχής του γονιδίου του ανθρώπινου υποθαλαµικού εκλυτικού παράγοντα της κορτικοτροπίνης (CRH) σε διαµολυσµένα ανθρώπινα ενδοµητρικά κύτταρα. 42η Επιστηµονική συνεδρία, Ελληνική Βιοχηµική και Βιοφυσική Εταιρεία, Αθήνα 1995. 5. Ε. Ζουµάκης, A. Μακρυγιαννάκης, Α. Μαργιωρής, Χ. Στουρνάρας, Α. Γραβάνης. Ο ενδοµητρικός εκλυτικός παράγοντας της κορτικοτροπίνης (CRH): έκφραση, ρύθµιση και φυσιολογικός ρόλος. 8ο Πανελλήνιο Φαρµακευτικό συνέδριο, Αθήνα 5-7 Οκτωβρίου 1996, Κ12

14 6. E. Ζουµάκης, Α Μαργιωρής, Ε ερµιτζάκη, Ε Αγγελάκης, Ε Κουµαντάκης, A. Γραβάνης. Προσδιορισµός της PGE2 και IL-6 ως παράγοντες των παρακρινών δράσεων του ενδοµητρικού εκλυτικού παράγοντα της κορτικοτροπίνης (CRH) στη ρύθµιση της διαφοροποίησης των στρωµατικών ενδοµητρικών κυττάρων. 2 ο Πανελλήνιο συνέδριο Κλινικής Χηµείας, Αθήνα, Νοέµβριος 1998.