16 4 2004 7 PROGRESS IN CHEMISTRY Vol. 16 No. 4 July 2004 3 ( 510275) : Q50 : A : 10052281X(2004) 0420660207 Consideration on the Development Strategy of Bioinorganic Chemistry in China Mao Zongwan An Yan Ji Liangnian 3 (School of Chemistry and Chemical Engineering Sun Yat2Sen University Guangzhou 510275 China) Abstract Development history and recent hot fields of bioinorganic chemistry internationally and achievements by Chinese scientists in this field are briefly reviewed. Future strategy for development of bioinorganic chemistry in China is discussed. Key words bioinorganic chemistry ; inorganic biochemistry ; developing strategy ( RSC2 10 CBF) (www. rsc. orgπchembiol) Synthesis and Biology Protein Dynam2 4 ] ics and Force Generation [1 2003 10 RSCCBF : 2001 10 (DFT ) (tu2 : 2004 3 : 2004 5 3 e2mail :cesjln @zsu. edu. cn
4 661 torial lecture) 1990 ; (1994) (1997) (1999) (2001) (2003) ;8 2004 4 :1 1984 ;2 1986 20 50 60 72 ;3 1989 73 Kendrew [5 ] Perutz [6 ] 192 ;4 7 X (1994) (2000) 40 1971 Schrauzer Bioinorganic Chemistry 1979 Journal of Inorganic Biochemistry 20 70 1995 (SBIC) 41 510 SBIC Jour2 1970 Virginia nal of Biological Inorganic Chemistry 7 ( PNAS) 19 50 R. F. Gould Bioinorganic Chemistry 20 70 1976 6 16 20 3 : (1) ( ICBIC20!) 13 1983 70 2 10 Algarve (2) (1985) Leiden (1987) Cambridge MA (1989) Oxford (1991) Lajolla CA (1993) Lubeck (1995) Yokohama (1997) Minnesota (1999) Florence 2 1992 ;3 7 (2001) 2003 Carins (3) 11 2003 2009 14 10 J. Webb :1 10
662 16 10 [11 ] 2003 7 PNAS : Valantine CuZn2SOD ;Bertini Banci Gramnegative [12 ] 1995 9 7 MIT S. J. Lippard 20 90 methylococcus capsulatus ( PNAS ) Rosenzweig EPR X 50 ( http :ΠΠcmbi. bjmu. ( EXAFS) X edu. cnπnewsπreportπ2003 Πinorganic. htm) Gray (XANES) Bertini PNAS 21 [13 ] Ragsdale Moorella ther2 [7 8 ] moacetica CO Π CoA 11 Cu2Ni Fe 4 2S 4 [14 ] Riordan NH2S [15 ] 11 ; Sadler [16 ] Williams 20 50 [9 ] P450 P450 [17 ] Theil : 70 B12 ; Co ( ) [10 ] 2 90 1993 6 N 2 D. C.
4 663 Rees Franklin NMR CD N 2 NH 3 [21 ] ; Kimura [22 ] ;Barton [23 DNA ] Enemark Lichtenberger Tullius DFT DNA [24 DNA ] ;Lippert [18 ] [25 2 ] ; Reedijk DNA [26 ] (V) (haloperoxidases) MRI 2003 7 azurin 2 c 11 P. A. Lay 31 ( ) Vincent [19 ] 1992 8 4 200 Dunitz [20 ] Winge S. J. Lippard A. Butler amphibactins 21 1976 40 :
664 16 [32 ] 41 11 21 2 2 2 Pecoraro [27 ] ( ) 1996 Winkler Gray [28 ] ; Chang Lee c 100 ns [29 ] Co ( ) ( ) ( ) ( [30 31 ] ) (ALS) ( 1997 ) 2 Π 20 ( )
4 665 21 21 : Biotechnology and Biological Sciences Research Council Funding (BBSRCF) Engineering and Physical Science Research Council Funding ( EPSRCF) [3] BBSRCF EPSRCF Biomolecular Science (BMS) [4] Engineering and Biological System ( EBS) BMS EMS 31 ( subject groups) sub2 ject groups RSCCBF 70 subject groups : Inorganic Reaction Mechanisms Discussion Group (Dalton Division ) Molecular Modelling Discussion Group ( Industrial Affairs Division ) Nacleic Acid and Molecular Biology Group (Perkin Division ) An2 alytical Bioscience Group (Analytical Division ) [ 1 ] (Wang K). (Bull. NNSF China) 1994 2 : 117 123 [2] (Wang K) (Han W S).. : 1997 (Zhang HJ) (Hong G Y) (Li D Q) (Niu C J) (Ni J Z). (Chemistry) 2001 6 : 523 529 ( Yang P). (Chemistry) 1999 12 : 1 11 [5] Kendrew J C Dickerson R E Strandberg B E Hart R G Phill2 ips D C Shore V C. Nature 1960 185 : 422 427 [6] Perutz M F Rossmann M G Cullis A F Muirhead H Will G North A C T. Nature 1960 185 : 416 422 [7] Gray H B. Proc. Natl. Acad. Sci. USA 2003 100 : 3563 3568 [8] Bertini I Rosato A. Proc. Natl. Acad. Sci. USA 2003 100 : 3601 3604 [9] Williams R J P Moore G R Wright P E. Biological Aspects of Inorganic Chemistry (eds. Addison A W Cullen W R Dolphin D James B R). New York : Wiley 1977. 369 401 [10] Liu X Jin W Theil E C. Proc. Natl. Acad. Sci. USA 2003 100 : 3653 3658 [11] Einsle O Tezcan F A Andrade S L A et al. Science 2002 297 : 1696 1700 [12] Arnesano F Banci L Bertini I Mangani S Thompsett A R. Proc. Natl. Acad. Sci. USA 2003 100 : 3814 3819 [13] Lieberman R L Shrestha D B Doan P E Hoffman B M Stemmler T L Rosenzweig A C. Proc. Natl. Acad. Sci. USA 2003 100 : 3820 3825 [14] Seravalli J Gu W Tam A Ragsdale S W et al. Proc. Natl. Acad. Sci. USA 2003 100 : 3689 3694 [15] Chiou SJ Riordan C G Rheingold A L. Proc. Natl. Acad. Sci. USA 2003 100 : 3695 3700 [16] Stewart A J Blindauer C A Berezenko S et al. Proc. Natl. Acad. Sci. USA 2003 100 : 3701 3706 [17] Maneiro M Ruettinger W F Bourles E et al. Proc. Natl. Acad. Sci. USA 2003 100 : 3707 3712 [18] Joshi H K Cooney J J A Inscore F E et al. Proc. Natl. Acad. Sci. USA 2003 100 : 3719 3724 [19] Hepburn D D D Xiao J Bindom S et al. Proc. Natl. Acad. Sci. USA 2003 100 : 3766 3771 [20] Dunitz J D Dobler M. Biological Aspects of Inorganic Chemistry (eds. Addison A W Cullen W R Dolphin D James B R). New York : Wiley 1977 113 140
666 16 [21] Welch J T Kearney W R Franklin S J. Proc. Natl. Acad. Sci. USA 2003 100 : 3725 3730 [22] Kimura E Aoki S Kikuta E Koike T. Proc. Natl. Acad. Sci. USA 2003 100 : 3731 3736 [23] Junicke H Hart J R Kisko J et al. Proc. Natl. Acad. Sci. USA 2003 100 : 3737 3742 [24] Guo H Tullius T D. Proc. Natl. Acad. Sci. USA 2003 100 : 3743 3747 [25] Freisinger E Rother I B Lu M S et al. Proc. Natl. Acad. Sci. USA 2003 100 : 3748 3753 [26] Reedijk J. Proc. Natl. Acad. Sci. USA 2003 100 : 3611 3616 [27] Farrer B T Pecoraro V L. Proc. Natl. Acad. Sci. USA 2003 100 : 3760 3765 [28] Pascher T Chesick J P Winkler J R et al. Science 1996 271 : 1558 1560 [29] Chang I J Lee J C Winkler J R et al. Proc. Natl. Acad. Sci. USA 2003 100 : 3838 3840 [30] Dobson C M. Trends Biochem. Sci. 1999 24 : 329 332 [31] Dobson C M. Philos. Trans. Roy. Soc. B 2001 356 : 133 145 [32] (Huang Z X) (Liu Y Q). (Chem. J. Chin. Univ. ) 1998 19 : 1904 1914 [33] (Chen R) (Han W S) (Wang K). (Prog. Chem. ) 1999 11 : 217 218 [34] (Chen R) (Han W S) (Wang K). (Prog. Chem. ) 2000 11 : 114 115 [35] (Ji L N) (Zhang Q L) (Chao H). (Chin. Sci. Bull. ) 2001 46 : 451 460 [36] ( Yang P) ( Song Y F). ( Prog. Chem. ) 2000 12 : 33 41 [37] ( Yang X D) ( Yang X G). ( Prog. Chem. ) 2002 14 : 273 278 [38] (Sun H) (Chen R) (Che C). (Prog. Chem. ) 2002 14 : 257 262 [39] (Liu Q) (Zhang J Y) ( Guo Z J ) (Tang W X). ( Prog. Chem. ) 2002 14 : 292 295 [40] ( Huang Z X). ( Prog. Chem. ) 2002 14 : 318 322 [41] (Jiang M) (Shen T) (Xu H B) (Liu C L). (Prog. Chem. ) 2002 14 : 263 272