Data-Driven Discovery of Extravasation Pathway in Circulating Tumor Cells

Data-Driven Discovery of Extravasation Pathway in Circulating Tumor Cells Yadavalli S. 1, Jayaram S. 1,2, Manda SS. 1,3, Madugundu AK. 1,3, Nayakanti DS. 1, Tuan TZ. 6, Bhat R. 4, Rangarajan A. 4, Chatterjee A. 1,5, Gowda H. 1,5, Thiery JP. 6,7,8, Kumar P 1. 1 Institute of Bioinformatics, International Technology Park, Whitefield, Bangalore, 560 066, India. 2 Manipal University, Madhav Nagar, Manipal, 576104, India. 3 Center for Bioinformatics, Pondicherry University, Puducherry 605 014, India. 4 Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, 560012, India. 5 YU-IOB Center for Systems Biology and Molecular Medicine, Yenepoya University, Mangalore, 575018, India. 6 Cancer Science Institute of Singapore, National University of Singapore, Centre for Translational Medicine NUS Yong Loo Lin School of Medicine, Singapore 117599, Singapore. 7 Comprehensive Cancer Center, Institut Gustave Roussy, 114 Rue Edouard Vaillant, 94805 Villejuif, France; CNRS UMR 7057, Matter and Complex Systems, Université Paris Diderot, 10 rue Alice Domon et Léonie Duquet 75013 Paris, France. 8 Department of Biochemistry, National University of Singapore, Singapore 117597, Singapore. Correspondence and requests for materials should be addressed to Kumar P. (email: prashant@ibioinformatics.org) 1

Supplementary Information As shown in the supplementary figure 1a, the total number of papers that resulted from PubMed search with keyword circulating tumor cells signaling is 1,073 (blue portion of the Venn diagram; 378+648+45+2 publications). This includes the papers that were common to results from keyword searches circulating tumor cells signaling and cancer (648); circulating tumor cells signaling and epithelial mesenchymal transition (2); and results common to all three keyword searches (45). The papers unique to the last two searches were excluded as they were not relevant. After abstract-level screening of these 1,073 papers, 153 were narrowed down for in-depth screening. Similarly, as shown in the supplementary figure 1b, the total number of papers that resulted from PubMed search with keyword circulating tumor cells gene expression is 2,169 (blue portion of the Venn diagram; 488+214+424+1,043 publications). This includes the papers that were common to results from keyword searches circulating tumor cells genes (214); circulating tumor cells expression (1,043); and results common to all three keyword searches (424). The papers unique to the last two searches were excluded due to non-relevance and large numbers. After abstract-level screening of these 2,169 papers, 78 were narrowed down for in-depth screening. Out of these 231 papers (153+78), 98 papers were found to have gene expression data relevant to CTCs from which the gene list was compiled for our analysis. Of these, 93 papers were smallscale qualitative and semi-quantitative experiments that reported expression of a few genes in CTCs. The remaining five papers were based on large-scale transcriptomic experiments (RNA- Seq and Microarray) and reported differential expression of hundreds of genes in CTCs. The final gene list for our pathway analysis comprises mostly of genes from these five papers (7,209 out 7,572 total numbers of genes). These numbers are reported as CTC_ALL (7,572 genes from all 98 papers) out of which 7,209 (CTC_FC) were taken from the five large-scale transcriptomics experiment papers (Supplementary Table S1 and Supplementary Table S2, respectively). The reference information (PubMed IDs; PMIDs) for the 98 papers are listed in Supplementary Table S5. 2

Supplementary Figures Supplementary Figure 1: Venn diagrams showing overlap between research articles when searched with keywords in Pubmed. (a) PubMed results with keywords containing circulating tumor cells signaling ; (b) PubMed results with keywords containing circulating tumor cells gene expression ; (c) Venn diagram showing number of differentially expressed genes in circulating tumor cells taken from semi-quantitative and qualitative experiments shown in CTC_ALL (n=7,572). Subset of differentially expressed genes from semi-quantitative experiments from five cancer studies is shown as CTC_FC (n=7,209). 3

Supplementary Figure 2: Venn diagram showing the number of genes differentially expressed in CTCs in the five cancers. Number of genes overexpressed in CTCs when compared to primary tumors (a), peripheral blood mononuclear cells (PBMCs) (b), normal tissue (c). Number of genes downregulated in CTCs when compared to primary tumors (d), PBMCs (e), normal tissue (f). 4

Supplementary Figure 3: Swarm plot shows the distribution of differentially expressed epithelial (green) and mesenchymal (blue) genes across the five cancer datasets. The genes are further segregated on their expression as epithelial or mesenchymal markers based on published literature. PRCTC1 denotes prostate CTCs gene expression when compared to primary tumors; CRCTC1 colorectal CTCs when compared to PBMCs; MNCTC1 melanoma CTCs/melanoma cell lines; MNCTC2 melanoma CTCs/primary melanocytes; PACTC1 pancreatic CTCs/nontumoral pancreatic tissue; PACTC2 pancreatic CTCs/PBMCs; PACTC3 pancreatic CTCs/primary tumors; BRCTC1 breast CTCs/breast epithelium; BRCTC2 breast CTCs/PBMCs; BRCTC3 breast CTCs/primary tumors. 5

Supplementary Figure 4: Comparison of EMT scores of CTC gene expression data for the five cancers with a) EMT scores of tumors and b) EMT scores of cancer cell lines. The CTC dataset labels are highlighted in boxes. 6

Supplementary Tables Supplementary Table S1: CTC_ALL: Differentially expressed genes in circulating tumor cells when compared with primary tumors, PBMCs, normal tissue and tumor cell lines. Expression data for a total number of 7,572 genes were obtained from reported literature of semiquantitative and qualitative experiments. Supplementary Table S2: CTC_FC: Differentially expressed genes in circulating tumor cells when compared with primary tumors, PBMCs, normal tissue and tumor cell lines. Data for a total of 7,209 genes were obtained from reported literature of transcriptomics experiments from five different cancer studies of CTCs. Supplementary Table S3: CTC isolation and purity confirmation techniques used by the five high-throughput experiments from which differentially expressed genes with fold change values (CTC_FC) was compiled for data analysis in our study. Supplementary Table S4: List of molecular interactions reported in the literature (PubMed IDs included) and depicted in the leukocyte/ctc extravasation pathway. Supplementary Table S5: PubMed IDs for 98 papers from which a gene list was compiled for molecular characterization of CTCs. This list includes the five large-scale transcriptomics experiment papers from which differentially expressed genes with fold change values were obtained (highlighted in yellow color). Supplementary Table S6: EMT scores computed from transcriptome datasets of CTCs in five cancers GSE18670, GSE31023, GSE38495, GSE45965, and GSE67980. The pre-processed data GSE45965 was also used. 7

Yadavalli et al., 2016. Data-Driven Discovery of Extravasation Pathway in Circulating Tumor Cells Supplementary Table S1: CTC_ALL: Differentially expressed genes in circulating tumor cells when compared to primary tumors, PBMC, normal tissue and tumor cell lines. Expression data for a total number of 7,572 genes were obtained from reported literature of semi-quantitative and qualitative experiments. Gene Symbol Gene ID Gene Description Fold change (log2) Arbitrary fold change (for CTC_ALL analysis) 1 RPS4Y1 6192 ribosomal protein S4, Y-linked 1 [Source:HGNC Symbol;Acc:HGNC:10425] 9.5 2 2 COX7B2 170712 cytochrome c oxidase subunit 7B2 [Source:HGNC Symbol;Acc:HGNC:24381] 9.3 2 3 GTSF1 121355 gametocyte specific factor 1 [Source:HGNC Symbol;Acc:HGNC:26565] 9.2 2 4 SMUG1 23583 single-strand-selective monofunctional uracil-dna glycosylase 1 [Source:HGNC Symbol;Acc:HGNC:17148] 9.1 2 5 PAGE5 90737 PAGE family member 5 [Source:HGNC Symbol;Acc:HGNC:29992] 8.4 2 6 TUBB1 81027 tubulin beta 1 class VI [Source:HGNC Symbol;Acc:HGNC:16257] 8.3 2 7 PPBP 5473 pro-platelet basic protein [Source:HGNC Symbol;Acc:HGNC:9240] 8.3 2 8 TMEFF2 23671 transmembrane protein with EGF like and two follistatin like domains 2 [Source:HGNC Symbol;Acc:HGNC:11867] 7.7 2 9 PF4 5196 platelet factor 4 [Source:HGNC Symbol;Acc:HGNC:8861] 7.6 2 10 ANKHD1 54882 ankyrin repeat and KH domain containing 1 [Source:HGNC Symbol;Acc:HGNC:24714] 7.4 2 11 ANKHD1-EIF4EBP3 404734 ANKHD1-EIF4EBP3 readthrough [Source:HGNC Symbol;Acc:HGNC:33530] 7.4 2 12 MLEC 9761 malectin [Source:HGNC Symbol;Acc:HGNC:28973] 7.3 2 13 S100A12 6283 S100 calcium binding protein A12 [Source:HGNC Symbol;Acc:HGNC:10489] 7.0 2 14 FCN1 2219 ficolin 1 [Source:HGNC Symbol;Acc:HGNC:3623] 6.9 2 15 ACRBP 84519 acrosin binding protein [Source:HGNC Symbol;Acc:HGNC:17195] 6.9 2 16 CCNB1 891 cyclin B1 [Source:HGNC Symbol;Acc:HGNC:1579] 6.8 2 17 NRGN 4900 neurogranin [Source:HGNC Symbol;Acc:HGNC:8000] 6.8 2 18 SREK1 140890 splicing regulatory glutamic acid and lysine rich protein 1 [Source:HGNC Symbol;Acc:HGNC:17882] 6.7 2 19 CENPM 79019 centromere protein M [Source:HGNC Symbol;Acc:HGNC:18352] 6.6 2 20 ANLN 54443 anillin actin binding protein [Source:HGNC Symbol;Acc:HGNC:14082] 6.5 2 21 KIAA0895 23366 KIAA0895 [Source:HGNC Symbol;Acc:HGNC:22206] 6.5 2 22 LYZ 4069 lysozyme [Source:HGNC Symbol;Acc:HGNC:6740] 6.5 2 23 CKAP4 10970 cytoskeleton-associated protein 4 [Source:HGNC Symbol;Acc:HGNC:16991] 6.5 2 24 ITGA2B 3674 integrin subunit alpha 2b [Source:HGNC Symbol;Acc:HGNC:6138] 6.5 2 25 TSG101 7251 tumor susceptibility 101 [Source:HGNC Symbol;Acc:HGNC:15971] 6.4 2 26 SRSF11 9295 serine and arginine rich splicing factor 11 [Source:HGNC Symbol;Acc:HGNC:10782] 6.4 2 27 SNX10 29887 sorting nexin 10 [Source:HGNC Symbol;Acc:HGNC:14974] 6.4 2 28 BMX 660 BMX non-receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:1079] 6.3 2 29 HIST1H3H 8357 histone cluster 1, H3h [Source:HGNC Symbol;Acc:HGNC:4775] 6.3 2 30 ECI2 10455 enoyl-coa delta isomerase 2 [Source:HGNC Symbol;Acc:HGNC:14601] 6.3 2 31 RUVBL1 8607 RuvB like AAA ATPase 1 [Source:HGNC Symbol;Acc:HGNC:10474] 6.3 2 32 MRPL46 26589 mitochondrial ribosomal protein L46 [Source:HGNC Symbol;Acc:HGNC:1192] 6.2 2 33 MAF1 84232 MAF1 homolog, negative regulator of RNA polymerase III [Source:HGNC Symbol;Acc:HGNC:24966] 6.0 2 34 PF4V1 5197 platelet factor 4 variant 1 [Source:HGNC Symbol;Acc:HGNC:8862] 6.0 2 35 YY1AP1 55249 YY1 associated protein 1 [Source:HGNC Symbol;Acc:HGNC:30935] 6.0 2 36 TIMMDC1 51300 translocase of inner mitochondrial membrane domain containing 1 [Source:HGNC Symbol;Acc:HGNC:1321] 5.9 2 37 LYAR 55646 Ly1 antibody reactive [Source:HGNC Symbol;Acc:HGNC:26021] 5.9 2 38 TAL1 6886 T-cell acute lymphocytic leukemia 1 [Source:HGNC Symbol;Acc:HGNC:11556] 5.9 2 39 SF3B6 51639 splicing factor 3b subunit 6 [Source:HGNC Symbol;Acc:HGNC:30096] 5.9 2 40 BUD31 8896 BUD31 homolog [Source:HGNC Symbol;Acc:HGNC:29629] 5.9 2 41 RPL10L 140801 ribosomal protein L10 like [Source:HGNC Symbol;Acc:HGNC:17976] 5.8 2 42 MGAM 8972 maltase-glucoamylase [Source:HGNC Symbol;Acc:HGNC:7043] 5.8 2 43 ALOX12 239 arachidonate 12-lipoxygenase, 12S type [Source:HGNC Symbol;Acc:HGNC:429] 5.8 2 44 CCNB2 9133 cyclin B2 [Source:HGNC Symbol;Acc:HGNC:1580] 5.8 2 45 CYFIP2 26999 cytoplasmic FMR1 interacting protein 2 [Source:HGNC Symbol;Acc:HGNC:13760] 5.8 2 46 TREML1 340205 triggering receptor expressed on myeloid cells like 1 [Source:HGNC Symbol;Acc:HGNC:20434] 5.8 2 47 DNAJA4 55466 DnaJ heat shock protein family (Hsp40) member A4 [Source:HGNC Symbol;Acc:HGNC:14885] 5.8 2 48 HBG1 3047 hemoglobin subunit gamma 1 [Source:HGNC Symbol;Acc:HGNC:4831] 5.8 2 49 FUNDC2 65991 FUN14 domain containing 2 [Source:HGNC Symbol;Acc:HGNC:24925] 5.7 2 50 RGS18 64407 regulator of G-protein signaling 18 [Source:HGNC Symbol;Acc:HGNC:14261] 5.7 2 51 KRTAP19-1 337882 keratin associated protein 19-1 [Source:HGNC Symbol;Acc:HGNC:18936] 5.7 2 52 LPXN 9404 leupaxin [Source:HGNC Symbol;Acc:HGNC:14061] 5.7 2 53 SLC35B1 10237 solute carrier family 35 member B1 [Source:HGNC Symbol;Acc:HGNC:20798] 5.7 2 54 USP15 9958 ubiquitin specific peptidase 15 [Source:HGNC Symbol;Acc:HGNC:12613] 5.7 2 55 NAMPT 10135 nicotinamide phosphoribosyltransferase [Source:HGNC Symbol;Acc:HGNC:30092] 5.7 2 56 AHSP 51327 alpha hemoglobin stabilizing protein [Source:HGNC Symbol;Acc:HGNC:18075] 5.7 2 57 EWSR1 2130 EWS RNA binding protein 1 [Source:HGNC Symbol;Acc:HGNC:3508] 5.7 2 58 CELF1 10658 CUGBP, Elav-like family member 1 [Source:HGNC Symbol;Acc:HGNC:2549] 5.7 2 59 IFT57 55081 intraflagellar transport 57 [Source:HGNC Symbol;Acc:HGNC:17367] 5.6 2 60 SLA2 84174 Src-like-adaptor 2 [Source:HGNC Symbol;Acc:HGNC:17329] 5.6 2 61 SERPINA3 12 serpin family A member 3 [Source:HGNC Symbol;Acc:HGNC:16] 5.6 2 62 HMGN4 10473 high mobility group nucleosomal binding domain 4 [Source:HGNC Symbol;Acc:HGNC:4989] 5.6 2 63 TPP2 7174 tripeptidyl peptidase 2 [Source:HGNC Symbol;Acc:HGNC:12016] 5.6 2 64 NLRC5 84166 NLR family CARD domain containing 5 [Source:HGNC Symbol;Acc:HGNC:29933] 5.6 2 65 GNAZ 2781 G protein subunit alpha z [Source:HGNC Symbol;Acc:HGNC:4395] 5.6 2 66 SERPINB6 5269 serpin family B member 6 [Source:HGNC Symbol;Acc:HGNC:8950] 5.6 2 67 CDKN3 1033 cyclin dependent kinase inhibitor 3 [Source:HGNC Symbol;Acc:HGNC:1791] 5.5 2 68 PNN 5411 pinin, desmosome associated protein [Source:HGNC Symbol;Acc:HGNC:9162] 5.5 2 69 TSTD1 100131187 thiosulfate sulfurtransferase like domain containing 1 [Source:HGNC Symbol;Acc:HGNC:35410] 5.5 2 70 CST7 8530 cystatin F [Source:HGNC Symbol;Acc:HGNC:2479] 5.4 2

71 IGF2BP3 10643 insulin like growth factor 2 mrna binding protein 3 [Source:HGNC Symbol;Acc:HGNC:28868] 5.4 2 72 CIAPIN1 57019 cytokine induced apoptosis inhibitor 1 [Source:HGNC Symbol;Acc:HGNC:28050] 5.4 2 73 RAB37 326624 RAB37, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:30268] 5.4 2 74 SDPR 8436 serum deprivation response [Source:HGNC Symbol;Acc:HGNC:10690] 5.4 2 75 AP3D1 8943 adaptor related protein complex 3 delta 1 subunit [Source:HGNC Symbol;Acc:HGNC:568] 5.4 2 76 MSL1 339287 male specific lethal 1 homolog [Source:HGNC Symbol;Acc:HGNC:27905] 5.4 2 77 PSMB8 5696 proteasome subunit beta 8 [Source:HGNC Symbol;Acc:HGNC:9545] 5.4 2 78 HIST1H2AG 8969 histone cluster 1, H2ag [Source:HGNC Symbol;Acc:HGNC:4737] 5.4 2 79 HMMR 3161 hyaluronan mediated motility receptor [Source:HGNC Symbol;Acc:HGNC:5012] 5.3 2 80 IL2RB 3560 interleukin 2 receptor subunit beta [Source:HGNC Symbol;Acc:HGNC:6009] 5.3 2 81 RBM18 92400 RNA binding motif protein 18 [Source:HGNC Symbol;Acc:HGNC:28413] 5.3 2 82 BUB1 699 BUB1 mitotic checkpoint serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:1148] 5.3 2 83 MAGEA10 4109 MAGE family member A10 [Source:HGNC Symbol;Acc:HGNC:6797] 5.3 2 84 MAGEA10-MAGEA5 100533997 MAGEA10-MAGEA5 Readthrough 5.3 2 85 ANKRD17 26057 ankyrin repeat domain 17 [Source:HGNC Symbol;Acc:HGNC:23575] 5.3 2 86 TMEM40 55287 transmembrane protein 40 [Source:HGNC Symbol;Acc:HGNC:25620] 5.3 2 87 AFTPH 54812 aftiphilin [Source:HGNC Symbol;Acc:HGNC:25951] 5.2 2 88 ATP2B1 490 ATPase plasma membrane Ca2+ transporting 1 [Source:HGNC Symbol;Acc:HGNC:814] 5.2 2 89 DCAF13 25879 DDB1 and CUL4 associated factor 13 [Source:HGNC Symbol;Acc:HGNC:24535] 5.2 2 90 SLC25A32 81034 solute carrier family 25 member 32 [Source:HGNC Symbol;Acc:HGNC:29683] 5.2 2 91 GFI1B 8328 growth factor independent 1B transcriptional repressor [Source:HGNC Symbol;Acc:HGNC:4238] 5.2 2 92 S100A8 6279 S100 calcium binding protein A8 [Source:HGNC Symbol;Acc:HGNC:10498] 5.2 2 93 TMEM87A 25963 transmembrane protein 87A [Source:HGNC Symbol;Acc:HGNC:24522] 5.2 2 94 ANKRD10 55608 ankyrin repeat domain 10 [Source:HGNC Symbol;Acc:HGNC:20265] 5.2 2 95 PTN 5764 pleiotrophin [Source:HGNC Symbol;Acc:HGNC:9630] 5.2 2 96 TRIP12 9320 thyroid hormone receptor interactor 12 [Source:HGNC Symbol;Acc:HGNC:12306] 5.1 2 97 KRT15 3866 keratin 15 [Source:HGNC Symbol;Acc:HGNC:6421] 5.1 2 98 ITGB2 3689 integrin subunit beta 2 [Source:HGNC Symbol;Acc:HGNC:6155] 5.1 2 99 WDR45B 56270 WD repeat domain 45B [Source:HGNC Symbol;Acc:HGNC:25072] 5.1 2 100 IFT20 90410 intraflagellar transport 20 [Source:HGNC Symbol;Acc:HGNC:30989] 5.1 2 101 FGR 2268 FGR proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:3697] 5.1 2 102 NR2C2 7182 nuclear receptor subfamily 2 group C member 2 [Source:HGNC Symbol;Acc:HGNC:7972] 5.1 2 103 TRA2A 29896 transformer 2 alpha homolog [Source:HGNC Symbol;Acc:HGNC:16645] 5.1 2 104 MT-ND6 4541 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 [Source:HGNC Symbol;Acc:HGNC:7462] 5.1 2 105 NUP93 9688 nucleoporin 93 [Source:HGNC Symbol;Acc:HGNC:28958] 5.1 2 106 MAGEB1 4112 MAGE family member B1 [Source:HGNC Symbol;Acc:HGNC:6808] 5.1 2 107 MAGEB4 4115 MAGE family member B4 [Source:HGNC Symbol;Acc:HGNC:6811] 5.1 2 108 ATP5S 27109 ATP synthase, H+ transporting, mitochondrial Fo complex subunit s (factor B) [Source:HGNC Symbol;Acc:HGNC:18799] 5.1 2 109 C2orf88 84281 chromosome 2 open reading frame 88 [Source:HGNC Symbol;Acc:HGNC:28191] 5.1 2 110 PAEP 5047 progestagen associated endometrial protein [Source:HGNC Symbol;Acc:HGNC:8573] 5.1 2 111 SAMD14 201191 sterile alpha motif domain containing 14 [Source:HGNC Symbol;Acc:HGNC:27312] 5.1 2 112 TMEM106C 79022 transmembrane protein 106C [Source:HGNC Symbol;Acc:HGNC:28775] 5.1 2 113 SPPL2B 56928 signal peptide peptidase like 2B [Source:HGNC Symbol;Acc:HGNC:30627] 5.1 2 114 CD247 919 CD247 molecule [Source:HGNC Symbol;Acc:HGNC:1677] 5.1 2 115 NUSAP1 51203 nucleolar and spindle associated protein 1 [Source:HGNC Symbol;Acc:HGNC:18538] 5.1 2 116 KIF5C 3800 kinesin family member 5C [Source:HGNC Symbol;Acc:HGNC:6325] 5.1 2 117 TRIM58 25893 tripartite motif containing 58 [Source:HGNC Symbol;Acc:HGNC:24150] 5.1 2 118 MKKS 8195 McKusick-Kaufman syndrome [Source:HGNC Symbol;Acc:HGNC:7108] 5.1 2 119 ERN2 10595 endoplasmic reticulum to nucleus signaling 2 [Source:HGNC Symbol;Acc:HGNC:16942] 5.1 2 120 PLK1 5347 polo like kinase 1 [Source:HGNC Symbol;Acc:HGNC:9077] 5.1 2 121 POM121 9883 POM121 transmembrane nucleoporin [Source:HGNC Symbol;Acc:HGNC:19702] 5.0 2 122 TMEM11 8834 transmembrane protein 11 [Source:HGNC Symbol;Acc:HGNC:16823] 5.0 2 123 SNRNP25 79622 small nuclear ribonucleoprotein U11/U12 subunit 25 [Source:HGNC Symbol;Acc:HGNC:14161] 5.0 2 124 PRAM1 84106 PML-RARA regulated adaptor molecule 1 [Source:HGNC Symbol;Acc:HGNC:30091] 5.0 2 125 GMPR2 51292 guanosine monophosphate reductase 2 [Source:HGNC Symbol;Acc:HGNC:4377] 5.0 2 126 ILF3 3609 interleukin enhancer binding factor 3 [Source:HGNC Symbol;Acc:HGNC:6038] 5.0 2 127 LUZP4 51213 leucine zipper protein 4 [Source:HGNC Symbol;Acc:HGNC:24971] 5.0 2 128 NUP35 129401 nucleoporin 35 [Source:HGNC Symbol;Acc:HGNC:29797] 5.0 2 129 SMPD1 6609 sphingomyelin phosphodiesterase 1 [Source:HGNC Symbol;Acc:HGNC:11120] 5.0 2 130 MBD6 114785 methyl-cpg binding domain protein 6 [Source:HGNC Symbol;Acc:HGNC:20445] 5.0 2 131 APOBEC3A 200315 apolipoprotein B mrna editing enzyme catalytic subunit 3A [Source:HGNC Symbol;Acc:HGNC:17343] 5.0 2 132 UNC13B 10497 unc-13 homolog B (C. elegans) [Source:HGNC Symbol;Acc:HGNC:12566] 5.0 2 133 TIMM8B 26521 translocase of inner mitochondrial membrane 8 homolog B (yeast) [Source:HGNC Symbol;Acc:HGNC:11818] 5.0 2 134 C6orf62 81688 chromosome 6 open reading frame 62 [Source:HGNC Symbol;Acc:HGNC:20998] 5.0 2 135 YWHAG 7532 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma [Source:HGNC Symbol;Acc:HGNC:12852] 5.0 2 136 FAM133B 257415 family with sequence similarity 133 member B [Source:HGNC Symbol;Acc:HGNC:28629] 5.0 2 137 CKAP2 26586 cytoskeleton associated protein 2 [Source:HGNC Symbol;Acc:HGNC:1990] 4.9 2 138 MAGEC2 51438 MAGE family member C2 [Source:HGNC Symbol;Acc:HGNC:13574] 4.9 2 139 ARL6IP1 23204 ADP ribosylation factor like GTPase 6 interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:697] 4.9 2 140 ALDH9A1 223 aldehyde dehydrogenase 9 family member A1 [Source:HGNC Symbol;Acc:HGNC:412] 4.9 2 141 UBE2V2 7336 ubiquitin conjugating enzyme E2 V2 [Source:HGNC Symbol;Acc:HGNC:12495] 4.9 2 142 LILRA2 11027 leukocyte immunoglobulin like receptor A2 [Source:HGNC Symbol;Acc:HGNC:6603] 4.9 2 143 GP9 2815 glycoprotein IX platelet [Source:HGNC Symbol;Acc:HGNC:4444] 4.9 2 144 PDZK1IP1 10158 PDZK1 interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:16887] 4.9 2

145 MAGEB2 4113 MAGE family member B2 [Source:HGNC Symbol;Acc:HGNC:6809] 4.9 2 146 PPP2R2A 5520 protein phosphatase 2 regulatory subunit Balpha [Source:HGNC Symbol;Acc:HGNC:9304] 4.9 2 147 C12orf75 387882 chromosome 12 open reading frame 75 [Source:HGNC Symbol;Acc:HGNC:35164] 4.9 2 148 PRKAR2B 5577 protein kinase camp-dependent type II regulatory subunit beta [Source:HGNC Symbol;Acc:HGNC:9392] 4.9 2 149 CFP 5199 complement factor properdin [Source:HGNC Symbol;Acc:HGNC:8864] 4.9 2 150 DNAJB7 150353 DnaJ heat shock protein family (Hsp40) member B7 [Source:HGNC Symbol;Acc:HGNC:24986] 4.9 2 151 XPNPEP3 63929 X-prolyl aminopeptidase 3, mitochondrial [Source:HGNC Symbol;Acc:HGNC:28052] 4.9 2 152 SELENBP1 8991 selenium binding protein 1 [Source:HGNC Symbol;Acc:HGNC:10719] 4.9 2 153 SMU1 55234 DNA replication regulator and spliceosomal factor [Source:HGNC Symbol;Acc:HGNC:18247] 4.9 2 154 SUMO2 6613 small ubiquitin-like modifier 2 [Source:HGNC Symbol;Acc:HGNC:11125] 4.9 2 155 SEC61B 10952 Sec61 translocon beta subunit [Source:HGNC Symbol;Acc:HGNC:16993] 4.9 2 156 PEF1 553115 penta-ef-hand domain containing 1 [Source:HGNC Symbol;Acc:HGNC:30009] 4.9 2 157 PRKCB 5579 protein kinase C beta [Source:HGNC Symbol;Acc:HGNC:9395] 4.9 2 158 TOP2B 7155 topoisomerase (DNA) II beta [Source:HGNC Symbol;Acc:HGNC:11990] 4.8 2 159 HK3 3101 hexokinase 3 [Source:HGNC Symbol;Acc:HGNC:4925] 4.8 2 160 SFSWAP 6433 splicing factor SWAP homolog [Source:HGNC Symbol;Acc:HGNC:10790] 4.8 2 161 PRRC2C 23215 proline rich coiled-coil 2C [Source:HGNC Symbol;Acc:HGNC:24903] 4.8 2 162 COA1 55744 cytochrome c oxidase assembly factor 1 homolog [Source:HGNC Symbol;Acc:HGNC:21868] 4.8 2 163 LILRB2 10288 leukocyte immunoglobulin like receptor B2 [Source:HGNC Symbol;Acc:HGNC:6606] 4.8 2 164 CCT2 10576 chaperonin containing TCP1 subunit 2 [Source:HGNC Symbol;Acc:HGNC:1615] 4.8 2 165 MAGED2 10916 MAGE family member D2 [Source:HGNC Symbol;Acc:HGNC:16353] 4.8 2 166 CDC20 991 cell division cycle 20 [Source:HGNC Symbol;Acc:HGNC:1723] 4.8 2 167 SNRPA1 6627 small nuclear ribonucleoprotein polypeptide A' [Source:HGNC Symbol;Acc:HGNC:11152] 4.8 2 168 MAP3K7CL 56911 MAP3K7 C-terminal like [Source:HGNC Symbol;Acc:HGNC:16457] 4.8 2 169 PADI4 23569 peptidyl arginine deiminase 4 [Source:HGNC Symbol;Acc:HGNC:18368] 4.8 2 170 SPX 80763 spexin hormone [Source:HGNC Symbol;Acc:HGNC:28139] 4.8 2 171 GZMB 3002 granzyme B [Source:HGNC Symbol;Acc:HGNC:4709] 4.8 2 172 RASGRP2 10235 RAS guanyl releasing protein 2 [Source:HGNC Symbol;Acc:HGNC:9879] 4.8 2 173 FAM133A 286499 family with sequence similarity 133 member A [Source:HGNC Symbol;Acc:HGNC:26748] 4.8 2 174 MPL 4352 MPL proto-oncogene, thrombopoietin receptor [Source:HGNC Symbol;Acc:HGNC:7217] 4.7 2 175 APOBEC3B 9582 apolipoprotein B mrna editing enzyme catalytic subunit 3B [Source:HGNC Symbol;Acc:HGNC:17352] 4.7 2 176 PTGS1 5742 prostaglandin-endoperoxide synthase 1 [Source:HGNC Symbol;Acc:HGNC:9604] 4.7 2 177 TIMM17A 10440 translocase of inner mitochondrial membrane 17 homolog A (yeast) [Source:HGNC Symbol;Acc:HGNC:17315] 4.7 2 178 NFE2 4778 nuclear factor, erythroid 2 [Source:HGNC Symbol;Acc:HGNC:7780] 4.7 2 179 MSN 4478 moesin [Source:HGNC Symbol;Acc:HGNC:7373] 4.7 2 180 CCNL1 57018 cyclin L1 [Source:HGNC Symbol;Acc:HGNC:20569] 4.7 2 181 NUP37 79023 nucleoporin 37 [Source:HGNC Symbol;Acc:HGNC:29929] 4.7 2 182 TMEM91 641649 transmembrane protein 91 [Source:HGNC Symbol;Acc:HGNC:32393] 4.7 2 183 ZNF185 7739 zinc finger protein 185 (LIM domain) [Source:HGNC Symbol;Acc:HGNC:12976] 4.7 2 184 PMM1 5372 phosphomannomutase 1 [Source:HGNC Symbol;Acc:HGNC:9114] 4.7 2 185 USP1 7398 ubiquitin specific peptidase 1 [Source:HGNC Symbol;Acc:HGNC:12607] 4.7 2 186 DLGAP5 9787 DLG associated protein 5 [Source:HGNC Symbol;Acc:HGNC:16864] 4.7 2 187 TROAP 10024 trophinin associated protein [Source:HGNC Symbol;Acc:HGNC:12327] 4.7 2 188 LUC7L3 51747 LUC7 like 3 pre-mrna splicing factor [Source:HGNC Symbol;Acc:HGNC:24309] 4.7 2 189 SRPRB 58477 SRP receptor beta subunit [Source:HGNC Symbol;Acc:HGNC:24085] 4.7 2 190 NFIL3 4783 nuclear factor, interleukin 3 regulated [Source:HGNC Symbol;Acc:HGNC:7787] 4.7 2 191 ADD3 120 adducin 3 [Source:HGNC Symbol;Acc:HGNC:245] 4.7 2 192 TAP1 6890 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) [Source:HGNC Symbol;Acc:HGNC:43] 4.7 2 193 DLD 1738 dihydrolipoamide dehydrogenase [Source:HGNC Symbol;Acc:HGNC:2898] 4.7 2 194 SLC25A38 54977 solute carrier family 25 member 38 [Source:HGNC Symbol;Acc:HGNC:26054] 4.7 2 195 PLOD1 5351 procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 [Source:HGNC Symbol;Acc:HGNC:9081] 4.7 2 196 PABPN1 8106 poly(a) binding protein nuclear 1 [Source:HGNC Symbol;Acc:HGNC:8565] 4.6 2 197 GAL3ST4 79690 galactose-3-o-sulfotransferase 4 [Source:HGNC Symbol;Acc:HGNC:24145] 4.6 2 198 DZIP3 9666 DAZ interacting zinc finger protein 3 [Source:HGNC Symbol;Acc:HGNC:30938] 4.6 2 199 KIAA1524 57650 KIAA1524 [Source:HGNC Symbol;Acc:HGNC:29302] 4.6 2 200 C10orf54 64115 chromosome 10 open reading frame 54 [Source:HGNC Symbol;Acc:HGNC:30085] 4.6 2 201 MFAP3L 9848 microfibrillar associated protein 3 like [Source:HGNC Symbol;Acc:HGNC:29083] 4.6 2 202 CTTN 2017 cortactin [Source:HGNC Symbol;Acc:HGNC:3338] 4.6 2 203 VPS28 51160 VPS28, ESCRT-I subunit [Source:HGNC Symbol;Acc:HGNC:18178] 4.6 2 204 DCTN3 11258 dynactin subunit 3 [Source:HGNC Symbol;Acc:HGNC:2713] 4.6 2 205 CCDC152 100129792 coiled-coil domain containing 152 [Source:HGNC Symbol;Acc:HGNC:34438] 4.6 2 206 SEPP1 6414 selenoprotein P, plasma, 1 [Source:HGNC Symbol;Acc:HGNC:10751] 4.6 2 207 PSMC2 5701 proteasome 26S subunit, ATPase 2 [Source:HGNC Symbol;Acc:HGNC:9548] 4.6 2 208 TMED2 10959 transmembrane p24 trafficking protein 2 [Source:HGNC Symbol;Acc:HGNC:16996] 4.6 2 209 EIF2S2 8894 eukaryotic translation initiation factor 2 subunit beta [Source:HGNC Symbol;Acc:HGNC:3266] 4.6 2 210 S100A9 6280 S100 calcium binding protein A9 [Source:HGNC Symbol;Acc:HGNC:10499] 4.6 2 211 SYTL5 94122 synaptotagmin like 5 [Source:HGNC Symbol;Acc:HGNC:15589] 4.6 2 212 RIN3 79890 Ras and Rab interactor 3 [Source:HGNC Symbol;Acc:HGNC:18751] 4.6 2 213 HNRNPH3 3189 heterogeneous nuclear ribonucleoprotein H3 [Source:HGNC Symbol;Acc:HGNC:5043] 4.6 2 214 CMTM5 116173 CKLF like MARVEL transmembrane domain containing 5 [Source:HGNC Symbol;Acc:HGNC:19176] 4.6 2 215 FAM136A 84908 family with sequence similarity 136 member A [Source:HGNC Symbol;Acc:HGNC:25911] 4.6 2 216 SYCP3 50511 synaptonemal complex protein 3 [Source:HGNC Symbol;Acc:HGNC:18130] 4.6 2 217 C11orf21 29125 chromosome 11 open reading frame 21 [Source:HGNC Symbol;Acc:HGNC:13231] 4.6 2 218 GNG10 2790 G protein subunit gamma 10 [Source:HGNC Symbol;Acc:HGNC:4402] 4.6 2

219 DNAJC25-GNG10 552891 DNAJC25-GNG10 readthrough [Source:HGNC Symbol;Acc:HGNC:37501] 4.6 2 220 DAPP1 27071 dual adaptor of phosphotyrosine and 3-phosphoinositides 1 [Source:HGNC Symbol;Acc:HGNC:16500] 4.6 2 221 MRPL22 29093 mitochondrial ribosomal protein L22 [Source:HGNC Symbol;Acc:HGNC:14480] 4.6 2 222 HJURP 55355 Holliday junction recognition protein [Source:HGNC Symbol;Acc:HGNC:25444] 4.6 2 223 ALDH3A2 224 aldehyde dehydrogenase 3 family member A2 [Source:HGNC Symbol;Acc:HGNC:403] 4.6 2 224 SPATA20 64847 spermatogenesis associated 20 [Source:HGNC Symbol;Acc:HGNC:26125] 4.6 2 225 C4orf19 55286 chromosome 4 open reading frame 19 [Source:HGNC Symbol;Acc:HGNC:25618] 4.6 2 226 RELL1 768211 RELT like 1 [Source:HGNC Symbol;Acc:HGNC:27379] 4.6 2 227 TSPAN33 340348 tetraspanin 33 [Source:HGNC Symbol;Acc:HGNC:28743] 4.5 2 228 CLEC12A 160364 C-type lectin domain family 12 member A [Source:HGNC Symbol;Acc:HGNC:31713] 4.5 2 229 C19orf33 64073 chromosome 19 open reading frame 33 [Source:HGNC Symbol;Acc:HGNC:16668] 4.5 2 230 UGP2 7360 UDP-glucose pyrophosphorylase 2 [Source:HGNC Symbol;Acc:HGNC:12527] 4.5 2 231 CCDC169 728591 coiled-coil domain containing 169 [Source:HGNC Symbol;Acc:HGNC:34361] 4.5 2 232 CCDC169-SOHLH2 100526761 CCDC169-SOHLH2 readthrough [Source:HGNC Symbol;Acc:HGNC:38866] 4.5 2 233 SOHLH2 54937 spermatogenesis and oogenesis specific basic helix-loop-helix 2 [Source:HGNC Symbol;Acc:HGNC:26026] 4.5 2 234 NOV 4856 nephroblastoma overexpressed [Source:HGNC Symbol;Acc:HGNC:7885] 4.5 2 235 ATF3 467 activating transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:785] 4.5 2 236 PSMA5 5686 proteasome subunit alpha 5 [Source:HGNC Symbol;Acc:HGNC:9534] 4.5 2 237 AURKA 6790 aurora kinase A [Source:HGNC Symbol;Acc:HGNC:11393] 4.5 2 238 PRF1 5551 perforin 1 [Source:HGNC Symbol;Acc:HGNC:9360] 4.5 2 239 DNAJA2 10294 DnaJ heat shock protein family (Hsp40) member A2 [Source:HGNC Symbol;Acc:HGNC:14884] 4.5 2 240 CSF3R 1441 colony stimulating factor 3 receptor [Source:HGNC Symbol;Acc:HGNC:2439] 4.5 2 241 CHORDC1 26973 cysteine and histidine rich domain containing 1 [Source:HGNC Symbol;Acc:HGNC:14525] 4.5 2 242 NCF4 4689 neutrophil cytosolic factor 4 [Source:HGNC Symbol;Acc:HGNC:7662] 4.5 2 243 RACGAP1 29127 Rac GTPase activating protein 1 [Source:HGNC Symbol;Acc:HGNC:9804] 4.5 2 244 TCEAL8 90843 transcription elongation factor A like 8 [Source:HGNC Symbol;Acc:HGNC:28683] 4.5 2 245 S100A16 140576 S100 calcium binding protein A16 [Source:HGNC Symbol;Acc:HGNC:20441] 4.5 2 246 GFOD1 54438 glucose-fructose oxidoreductase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:21096] 4.5 2 247 RUFY1 80230 RUN and FYVE domain containing 1 [Source:HGNC Symbol;Acc:HGNC:19760] 4.5 2 248 EIF5 1983 eukaryotic translation initiation factor 5 [Source:HGNC Symbol;Acc:HGNC:3299] 4.5 2 249 PGM2 55276 phosphoglucomutase 2 [Source:HGNC Symbol;Acc:HGNC:8906] 4.5 2 250 ASNS 440 asparagine synthetase (glutamine-hydrolyzing) [Source:HGNC Symbol;Acc:HGNC:753] 4.5 2 251 LILRA3 11026 leukocyte immunoglobulin like receptor A3 [Source:HGNC Symbol;Acc:HGNC:6604] 4.5 2 252 MRRF 92399 mitochondrial ribosome recycling factor [Source:HGNC Symbol;Acc:HGNC:7234] 4.5 2 253 YY1 7528 YY1 transcription factor [Source:HGNC Symbol;Acc:HGNC:12856] 4.5 2 254 TOP1 7150 topoisomerase (DNA) I [Source:HGNC Symbol;Acc:HGNC:11986] 4.5 2 255 FAM192A 80011 family with sequence similarity 192 member A [Source:HGNC Symbol;Acc:HGNC:29856] 4.5 2 256 DRAP1 10589 DR1 associated protein 1 [Source:HGNC Symbol;Acc:HGNC:3019] 4.4 2 257 OGT 8473 O-linked N-acetylglucosamine (GlcNAc) transferase [Source:HGNC Symbol;Acc:HGNC:8127] 4.4 2 258 TCAF1 9747 TRPM8 channel associated factor 1 [Source:HGNC Symbol;Acc:HGNC:22201] 4.4 2 259 ITM2A 9452 integral membrane protein 2A [Source:HGNC Symbol;Acc:HGNC:6173] 4.4 2 260 SLC25A36 55186 solute carrier family 25 member 36 [Source:HGNC Symbol;Acc:HGNC:25554] 4.4 2 261 RAP1GDS1 5910 Rap1 GTPase-GDP dissociation stimulator 1 [Source:HGNC Symbol;Acc:HGNC:9859] 4.4 2 262 PPM1A 5494 protein phosphatase, Mg2+/Mn2+ dependent 1A [Source:HGNC Symbol;Acc:HGNC:9275] 4.4 2 263 DPEP2 64174 dipeptidase 2 [Source:HGNC Symbol;Acc:HGNC:23028] 4.4 2 264 HBA2 3040 hemoglobin subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:4824] 4.4 2 265 UBE2E3 10477 ubiquitin conjugating enzyme E2 E3 [Source:HGNC Symbol;Acc:HGNC:12479] 4.4 2 266 WIPI1 55062 WD repeat domain, phosphoinositide interacting 1 [Source:HGNC Symbol;Acc:HGNC:25471] 4.4 2 267 CHD4 1108 chromodomain helicase DNA binding protein 4 [Source:HGNC Symbol;Acc:HGNC:1919] 4.4 2 268 GP1BA 2811 glycoprotein Ib platelet alpha subunit [Source:HGNC Symbol;Acc:HGNC:4439] 4.4 2 269 BEND2 139105 BEN domain containing 2 [Source:HGNC Symbol;Acc:HGNC:28509] 4.4 2 270 COMMD7 149951 COMM domain containing 7 [Source:HGNC Symbol;Acc:HGNC:16223] 4.4 2 271 FLII 2314 FLII, actin remodeling protein [Source:HGNC Symbol;Acc:HGNC:3750] 4.4 2 272 CHMP5 51510 charged multivesicular body protein 5 [Source:HGNC Symbol;Acc:HGNC:26942] 4.4 2 273 ADRM1 11047 adhesion regulating molecule 1 [Source:HGNC Symbol;Acc:HGNC:15759] 4.4 2 274 GZMH 2999 granzyme H [Source:HGNC Symbol;Acc:HGNC:4710] 4.4 2 275 RABIF 5877 RAB interacting factor [Source:HGNC Symbol;Acc:HGNC:9797] 4.4 2 276 PBK 55872 PDZ binding kinase [Source:HGNC Symbol;Acc:HGNC:18282] 4.4 2 277 PROK2 60675 prokineticin 2 [Source:HGNC Symbol;Acc:HGNC:18455] 4.4 2 278 ANKRD55 79722 ankyrin repeat domain 55 [Source:HGNC Symbol;Acc:HGNC:25681] 4.4 2 279 PAGE2B 389860 PAGE family member 2B [Source:HGNC Symbol;Acc:HGNC:31805] 4.4 2 280 GNLY 10578 granulysin [Source:HGNC Symbol;Acc:HGNC:4414] 4.4 2 281 SSB 6741 Sjogren syndrome antigen B [Source:HGNC Symbol;Acc:HGNC:11316] 4.4 2 282 RBM22 55696 RNA binding motif protein 22 [Source:HGNC Symbol;Acc:HGNC:25503] 4.4 2 283 MCL1 4170 myeloid cell leukemia 1 [Source:HGNC Symbol;Acc:HGNC:6943] 4.4 2 284 OSTC 58505 oligosaccharyltransferase complex subunit (non-catalytic) [Source:HGNC Symbol;Acc:HGNC:24448] 4.4 2 285 PILRB 29990 paired immunoglobin-like type 2 receptor beta [Source:HGNC Symbol;Acc:HGNC:18297] 4.4 2 286 SPDYE3 441272 speedy/ringo cell cycle regulator family member E3 [Source:HGNC Symbol;Acc:HGNC:35462] 4.4 2 287 ZNF467 168544 zinc finger protein 467 [Source:HGNC Symbol;Acc:HGNC:23154] 4.4 2 288 SRPX 8406 sushi repeat containing protein, X-linked [Source:HGNC Symbol;Acc:HGNC:11309] 4.4 2 289 CCDC73 493860 coiled-coil domain containing 73 [Source:HGNC Symbol;Acc:HGNC:23261] 4.3 2 290 TTK 7272 TTK protein kinase [Source:HGNC Symbol;Acc:HGNC:12401] 4.3 2 291 AKIRIN1 79647 akirin 1 [Source:HGNC Symbol;Acc:HGNC:25744] 4.3 2 292 IST1 9798 IST1, ESCRT-III associated factor [Source:HGNC Symbol;Acc:HGNC:28977] 4.3 2 293 SRP72 6731 signal recognition particle 72kDa [Source:HGNC Symbol;Acc:HGNC:11303] 4.3 2 294 CLUL1 27098 clusterin like 1 [Source:HGNC Symbol;Acc:HGNC:2096] 4.3 2

295 ENOSF1 55556 enolase superfamily member 1 [Source:HGNC Symbol;Acc:HGNC:30365] 4.3 2 296 TYMS 7298 thymidylate synthetase [Source:HGNC Symbol;Acc:HGNC:12441] 4.3 2 297 TYMSOS 494514 TYMS opposite strand [Source:HGNC Symbol;Acc:HGNC:29553] 4.3 2 298 APOD 347 apolipoprotein D [Source:HGNC Symbol;Acc:HGNC:612] 4.3 2 299 CENPK 64105 centromere protein K [Source:HGNC Symbol;Acc:HGNC:29479] 4.3 2 300 SURF2 6835 surfeit 2 [Source:HGNC Symbol;Acc:HGNC:11475] 4.3 2 301 C5orf15 56951 chromosome 5 open reading frame 15 [Source:HGNC Symbol;Acc:HGNC:20656] 4.3 2 302 LARP4 113251 La ribonucleoprotein domain family member 4 [Source:HGNC Symbol;Acc:HGNC:24320] 4.3 2 303 FRMD3 257019 FERM domain containing 3 [Source:HGNC Symbol;Acc:HGNC:24125] 4.3 2 304 CTNNAL1 8727 catenin alpha like 1 [Source:HGNC Symbol;Acc:HGNC:2512] 4.3 2 305 LGMN 5641 legumain [Source:HGNC Symbol;Acc:HGNC:9472] 4.3 2 306 MMP9 4318 matrix metallopeptidase 9 [Source:HGNC Symbol;Acc:HGNC:7176] 4.3 2 307 C8orf76 84933 chromosome 8 open reading frame 76 [Source:HGNC Symbol;Acc:HGNC:25924] 4.3 2 308 ZHX1 11244 zinc fingers and homeoboxes 1 [Source:HGNC Symbol;Acc:HGNC:12871] 4.3 2 309 ZHX1-C8orf76 100533106 ZHX1-C8orf76 readthrough [Source:HGNC Symbol;Acc:HGNC:42975] 4.3 2 310 HN1 51155 hematological and neurological expressed 1 [Source:HGNC Symbol;Acc:HGNC:14569] 4.3 2 311 TNFRSF1B 7133 tumor necrosis factor receptor superfamily member 1B [Source:HGNC Symbol;Acc:HGNC:11917] 4.3 2 312 MSMO1 6307 methylsterol monooxygenase 1 [Source:HGNC Symbol;Acc:HGNC:10545] 4.3 2 313 ARL4C 10123 ADP ribosylation factor like GTPase 4C [Source:HGNC Symbol;Acc:HGNC:698] 4.3 2 314 LTB4R 1241 leukotriene B4 receptor [Source:HGNC Symbol;Acc:HGNC:6713] 4.3 2 315 TTC1 7265 tetratricopeptide repeat domain 1 [Source:HGNC Symbol;Acc:HGNC:12391] 4.3 2 316 HMGB2 3148 high mobility group box 2 [Source:HGNC Symbol;Acc:HGNC:5000] 4.3 2 317 TMEM170B 100113407 transmembrane protein 170B [Source:HGNC Symbol;Acc:HGNC:34244] 4.3 2 318 PUM3 9933 pumilio RNA binding family member 3 [Source:HGNC Symbol;Acc:HGNC:29676] 4.3 2 319 HOMER2 9455 homer scaffolding protein 2 [Source:HGNC Symbol;Acc:HGNC:17513] 4.3 2 320 XRRA1 143570 X-ray radiation resistance associated 1 [Source:HGNC Symbol;Acc:HGNC:18868] 4.3 2 321 SNN 8303 stannin [Source:HGNC Symbol;Acc:HGNC:11149] 4.3 2 322 MTERF2 80298 mitochondrial transcription termination factor 2 [Source:HGNC Symbol;Acc:HGNC:30779] 4.3 2 323 FGD3 89846 FYVE, RhoGEF and PH domain containing 3 [Source:HGNC Symbol;Acc:HGNC:16027] 4.3 2 324 CCDC174 51244 coiled-coil domain containing 174 [Source:HGNC Symbol;Acc:HGNC:28033] 4.3 2 325 GLT1D1 144423 glycosyltransferase 1 domain containing 1 [Source:HGNC Symbol;Acc:HGNC:26483] 4.3 2 326 NKIRAS1 28512 NFKB inhibitor interacting Ras like 1 [Source:HGNC Symbol;Acc:HGNC:17899] 4.3 2 327 FERMT3 83706 fermitin family member 3 [Source:HGNC Symbol;Acc:HGNC:23151] 4.3 2 328 EGLN2 112398 egl-9 family hypoxia inducible factor 2 [Source:HGNC Symbol;Acc:HGNC:14660] 4.3 2 329 USP48 84196 ubiquitin specific peptidase 48 [Source:HGNC Symbol;Acc:HGNC:18533] 4.2 2 330 CNDP1 84735 carnosine dipeptidase 1 [Source:HGNC Symbol;Acc:HGNC:20675] 4.2 2 331 FAM65B 9750 family with sequence similarity 65 member B [Source:HGNC Symbol;Acc:HGNC:13872] 4.2 2 332 LARP1 23367 La ribonucleoprotein domain family member 1 [Source:HGNC Symbol;Acc:HGNC:29531] 4.2 2 333 AQP10 89872 aquaporin 10 [Source:HGNC Symbol;Acc:HGNC:16029] 4.2 2 334 FAM168B 130074 family with sequence similarity 168 member B [Source:HGNC Symbol;Acc:HGNC:27016] 4.2 2 335 TMEM200B 399474 transmembrane protein 200B [Source:HGNC Symbol;Acc:HGNC:33785] 4.2 2 336 P2RY12 64805 purinergic receptor P2Y12 [Source:HGNC Symbol;Acc:HGNC:18124] 4.2 2 337 CLU 1191 clusterin [Source:HGNC Symbol;Acc:HGNC:2095] 4.2 2 338 DDX3Y 8653 DEAD-box helicase 3, Y-linked [Source:HGNC Symbol;Acc:HGNC:2699] 4.2 2 339 STXBP2 6813 syntaxin binding protein 2 [Source:HGNC Symbol;Acc:HGNC:11445] 4.2 2 340 AK4 205 adenylate kinase 4 [Source:HGNC Symbol;Acc:HGNC:363] 4.2 2 341 BST2 684 bone marrow stromal cell antigen 2 [Source:HGNC Symbol;Acc:HGNC:1119] 4.2 2 342 SRRM1 10250 serine and arginine repetitive matrix 1 [Source:HGNC Symbol;Acc:HGNC:16638] 4.2 2 343 KXD1 79036 KxDL motif containing 1 [Source:HGNC Symbol;Acc:HGNC:28420] 4.2 2 344 PABPC3 5042 poly(a) binding protein cytoplasmic 3 [Source:HGNC Symbol;Acc:HGNC:8556] 4.2 2 345 PSMD4 5710 proteasome 26S subunit, non-atpase 4 [Source:HGNC Symbol;Acc:HGNC:9561] 4.2 2 346 TBXA2R 6915 thromboxane A2 receptor [Source:HGNC Symbol;Acc:HGNC:11608] 4.2 2 347 ZWINT 11130 ZW10 interacting kinetochore protein [Source:HGNC Symbol;Acc:HGNC:13195] 4.2 2 348 VAMP1 6843 vesicle associated membrane protein 1 [Source:HGNC Symbol;Acc:HGNC:12642] 4.2 2 349 HMHA1 23526 Mitochondrial Calcium Uniporter 4.2 2 350 RAD23A 5886 RAD23 homolog A, nucleotide excision repair protein [Source:HGNC Symbol;Acc:HGNC:9812] 4.2 2 351 PIN4 5303 peptidylprolyl cis/trans isomerase, NIMA-interacting 4 [Source:HGNC Symbol;Acc:HGNC:8992] 4.2 2 352 DGAT1 8694 diacylglycerol O-acyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:2843] 4.2 2 353 OVOS2 144203 Ovostatin 2 4.2 2 354 IQCJ 654502 IQ motif containing J [Source:HGNC Symbol;Acc:HGNC:32406] 4.2 2 355 IQCJ-SCHIP1 100505385 IQCJ-SCHIP1 readthrough [Source:HGNC Symbol;Acc:HGNC:38842] 4.2 2 356 SCHIP1 29970 schwannomin interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:15678] 4.2 2 357 PTPRJ 5795 protein tyrosine phosphatase, receptor type J [Source:HGNC Symbol;Acc:HGNC:9673] 4.2 2 358 DGAT2 84649 diacylglycerol O-acyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:16940] 4.2 2 359 KCNN2 3781 potassium calcium-activated channel subfamily N member 2 [Source:HGNC Symbol;Acc:HGNC:6291] 4.2 2 360 CORO1A 11151 coronin 1A [Source:HGNC Symbol;Acc:HGNC:2252] 4.2 2 361 UBE2N 7334 ubiquitin conjugating enzyme E2 N [Source:HGNC Symbol;Acc:HGNC:12492] 4.2 2 362 TMEM97 27346 transmembrane protein 97 [Source:HGNC Symbol;Acc:HGNC:28106] 4.2 2 363 GAS2L1 10634 growth arrest specific 2 like 1 [Source:HGNC Symbol;Acc:HGNC:16955] 4.2 2 364 TNC 3371 tenascin C [Source:HGNC Symbol;Acc:HGNC:5318] 4.2 2 365 SLC25A5 292 solute carrier family 25 member 5 [Source:HGNC Symbol;Acc:HGNC:10991] 4.2 2 366 DNM1L 10059 dynamin 1-like [Source:HGNC Symbol;Acc:HGNC:2973] 4.2 2 367 EIF1AY 9086 eukaryotic translation initiation factor 1A, Y-linked [Source:HGNC Symbol;Acc:HGNC:3252] 4.2 2 368 HMOX1 3162 heme oxygenase 1 [Source:HGNC Symbol;Acc:HGNC:5013] 4.2 2 369 FKBP3 2287 FK506 binding protein 3 [Source:HGNC Symbol;Acc:HGNC:3719] 4.2 2 370 CD36 948 CD36 molecule [Source:HGNC Symbol;Acc:HGNC:1663] 4.2 2 371 MAEA 10296 macrophage erythroblast attacher [Source:HGNC Symbol;Acc:HGNC:13731] 4.2 2 372 DOK3 79930 docking protein 3 [Source:HGNC Symbol;Acc:HGNC:24583] 4.2 2 373 PXN 5829 paxillin [Source:HGNC Symbol;Acc:HGNC:9718] 4.2 2

374 NUDT1 4521 nudix hydrolase 1 [Source:HGNC Symbol;Acc:HGNC:8048] 4.2 2 375 PCGF3 10336 polycomb group ring finger 3 [Source:HGNC Symbol;Acc:HGNC:10066] 4.2 2 376 SDHB 6390 succinate dehydrogenase complex iron sulfur subunit B [Source:HGNC Symbol;Acc:HGNC:10681] 4.2 2 377 SEMA4D 10507 semaphorin 4D [Source:HGNC Symbol;Acc:HGNC:10732] 4.1 2 378 RNF5 6048 ring finger protein 5 [Source:HGNC Symbol;Acc:HGNC:10068] 4.1 2 379 HIST2H2BE 8349 histone cluster 2, H2be [Source:HGNC Symbol;Acc:HGNC:4760] 4.1 2 380 IQGAP3 128239 IQ motif containing GTPase activating protein 3 [Source:HGNC Symbol;Acc:HGNC:20669] 4.1 2 381 PRPF31 26121 pre-mrna processing factor 31 [Source:HGNC Symbol;Acc:HGNC:15446] 4.1 2 382 FNTA 2339 farnesyltransferase, CAAX box, alpha [Source:HGNC Symbol;Acc:HGNC:3782] 4.1 2 383 CCR7 1236 C-C motif chemokine receptor 7 [Source:HGNC Symbol;Acc:HGNC:1608] 4.1 2 384 RSL24D1 51187 ribosomal L24 domain containing 1 [Source:HGNC Symbol;Acc:HGNC:18479] 4.1 2 385 UBE2L6 9246 ubiquitin conjugating enzyme E2 L6 [Source:HGNC Symbol;Acc:HGNC:12490] 4.1 2 386 ITGB3 3690 integrin subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:6156] 4.1 2 387 PAGE2 203569 PAGE family member 2 [Source:HGNC Symbol;Acc:HGNC:31804] 4.1 2 388 PTCRA 171558 pre T-cell antigen receptor alpha [Source:HGNC Symbol;Acc:HGNC:21290] 4.1 2 389 LCN2 3934 lipocalin 2 [Source:HGNC Symbol;Acc:HGNC:6526] 4.1 2 390 NBEAL2 23218 neurobeachin like 2 [Source:HGNC Symbol;Acc:HGNC:31928] 4.1 2 391 SUV420H1 51111 Lysine Methyltransferase 5B 4.1 2 392 ANKRD28 23243 ankyrin repeat domain 28 [Source:HGNC Symbol;Acc:HGNC:29024] 4.1 2 393 SCLY 51540 selenocysteine lyase [Source:HGNC Symbol;Acc:HGNC:18161] 4.1 2 394 ALDH18A1 5832 aldehyde dehydrogenase 18 family member A1 [Source:HGNC Symbol;Acc:HGNC:9722] 4.1 2 395 SERPINE1 5054 serpin family E member 1 [Source:HGNC Symbol;Acc:HGNC:8583] 4.1 2 396 CEP57 9702 centrosomal protein 57 [Source:HGNC Symbol;Acc:HGNC:30794] 4.1 2 397 ZNF263 10127 zinc finger protein 263 [Source:HGNC Symbol;Acc:HGNC:13056] 4.1 2 398 TCTN3 26123 tectonic family member 3 [Source:HGNC Symbol;Acc:HGNC:24519] 4.1 2 399 SLC25A10 1468 solute carrier family 25 member 10 [Source:HGNC Symbol;Acc:HGNC:10980] 4.1 2 400 CRIM1 51232 cysteine rich transmembrane BMP regulator 1 (chordin-like) [Source:HGNC Symbol;Acc:HGNC:2359] 4.1 2 401 SLC11A1 6556 solute carrier family 11 member 1 [Source:HGNC Symbol;Acc:HGNC:10907] 4.1 2 402 FAM110A 83541 family with sequence similarity 110 member A [Source:HGNC Symbol;Acc:HGNC:16188] 4.1 2 403 CCDC58 131076 coiled-coil domain containing 58 [Source:HGNC Symbol;Acc:HGNC:31136] 4.1 2 404 TMCO1 54499 transmembrane and coiled-coil domains 1 [Source:HGNC Symbol;Acc:HGNC:18188] 4.1 2 405 LGALSL 29094 galectin like [Source:HGNC Symbol;Acc:HGNC:25012] 4.1 2 406 XRCC4 7518 X-ray repair cross complementing 4 [Source:HGNC Symbol;Acc:HGNC:12831] 4.1 2 407 TPM1 7168 tropomyosin 1 (alpha) [Source:HGNC Symbol;Acc:HGNC:12010] 4.1 2 408 CXCR2 3579 C-X-C motif chemokine receptor 2 [Source:HGNC Symbol;Acc:HGNC:6027] 4.1 2 409 MYL9 10398 myosin light chain 9 [Source:HGNC Symbol;Acc:HGNC:15754] 4.1 2 410 KRTCAP3 200634 keratinocyte associated protein 3 [Source:HGNC Symbol;Acc:HGNC:28943] 4.1 2 411 PHF6 84295 PHD finger protein 6 [Source:HGNC Symbol;Acc:HGNC:18145] 4.1 2 412 FPR1 2357 formyl peptide receptor 1 [Source:HGNC Symbol;Acc:HGNC:3826] 4.1 2 413 ZBTB44 29068 zinc finger and BTB domain containing 44 [Source:HGNC Symbol;Acc:HGNC:25001] 4.1 2 414 CD37 951 CD37 molecule [Source:HGNC Symbol;Acc:HGNC:1666] 4.1 2 415 FAM162A 26355 family with sequence similarity 162 member A [Source:HGNC Symbol;Acc:HGNC:17865] 4.0 2 416 MARCH2 51257 membrane associated ring-ch-type finger 2 [Source:HGNC Symbol;Acc:HGNC:28038] 4.0 2 417 STX11 8676 syntaxin 11 [Source:HGNC Symbol;Acc:HGNC:11429] 4.0 2 418 NOP56 10528 NOP56 ribonucleoprotein [Source:HGNC Symbol;Acc:HGNC:15911] 4.0 2 419 CLEC2B 9976 C-type lectin domain family 2 member B [Source:HGNC Symbol;Acc:HGNC:2053] 4.0 2 420 RBCK1 10616 RANBP2-type and C3HC4-type zinc finger containing 1 [Source:HGNC Symbol;Acc:HGNC:15864] 4.0 2 421 CYB5A 1528 cytochrome b5 type A [Source:HGNC Symbol;Acc:HGNC:2570] 4.0 2 422 METAP2 10988 methionyl aminopeptidase 2 [Source:HGNC Symbol;Acc:HGNC:16672] 4.0 2 423 ADCY7 113 adenylate cyclase 7 [Source:HGNC Symbol;Acc:HGNC:238] 4.0 2 424 ESAM 90952 endothelial cell adhesion molecule [Source:HGNC Symbol;Acc:HGNC:17474] 4.0 2 425 EPCAM 4072 epithelial cell adhesion molecule [Source:HGNC Symbol;Acc:HGNC:11529] 4.0 2 426 BIRC5 332 baculoviral IAP repeat containing 5 [Source:HGNC Symbol;Acc:HGNC:593] 4.0 2 427 MEGF9 1955 multiple EGF like domains 9 [Source:HGNC Symbol;Acc:HGNC:3234] 4.0 2 428 DECR1 1666 2,4-dienoyl-CoA reductase 1, mitochondrial [Source:HGNC Symbol;Acc:HGNC:2753] 4.0 2 429 RNF34 80196 ring finger protein 34 [Source:HGNC Symbol;Acc:HGNC:17297] 4.0 2 430 PRPF40A 55660 pre-mrna processing factor 40 homolog A [Source:HGNC Symbol;Acc:HGNC:16463] 4.0 2 431 CCL5 6352 C-C motif chemokine ligand 5 [Source:HGNC Symbol;Acc:HGNC:10632] 4.0 2 432 NFIC 4782 nuclear factor I C [Source:HGNC Symbol;Acc:HGNC:7786] 4.0 2 433 SMIM5 643008 small integral membrane protein 5 [Source:HGNC Symbol;Acc:HGNC:40030] 4.0 2 434 PLAA 9373 phospholipase A2 activating protein [Source:HGNC Symbol;Acc:HGNC:9043] 4.0 2 435 CR1 1378 complement component 3b/4b receptor 1 (Knops blood group) [Source:HGNC Symbol;Acc:HGNC:2334] 4.0 2 436 VNN2 8875 vanin 2 [Source:HGNC Symbol;Acc:HGNC:12706] 4.0 2 437 CENPH 64946 centromere protein H [Source:HGNC Symbol;Acc:HGNC:17268] 4.0 2 438 VAPB 9217 VAMP (vesicle-associated membrane protein)-associated protein B and C [Source:HGNC Symbol;Acc:HGNC:12649] 4.0 2 439 HBG2 3048 hemoglobin subunit gamma 2 [Source:HGNC Symbol;Acc:HGNC:4832] 4.0 2 440 DOK2 9046 docking protein 2 [Source:HGNC Symbol;Acc:HGNC:2991] 4.0 2 441 PCSK6 5046 proprotein convertase subtilisin/kexin type 6 [Source:HGNC Symbol;Acc:HGNC:8569] 4.0 2 442 HGD 3081 homogentisate 1,2-dioxygenase [Source:HGNC Symbol;Acc:HGNC:4892] 4.0 2 443 GRINA 2907 glutamate ionotropic receptor NMDA type subunit associated protein 1 [Source:HGNC Symbol;Acc:HGNC:4589] 4.0 2 444 PPP1R10 5514 protein phosphatase 1 regulatory subunit 10 [Source:HGNC Symbol;Acc:HGNC:9284] 4.0 2 445 ARHGAP6 395 Rho GTPase activating protein 6 [Source:HGNC Symbol;Acc:HGNC:676] 4.0 2 446 ZDHHC9 51114 zinc finger DHHC-type containing 9 [Source:HGNC Symbol;Acc:HGNC:18475] 4.0 2 447 AKAP1 8165 A-kinase anchoring protein 1 [Source:HGNC Symbol;Acc:HGNC:367] 4.0 2 448 UNC119B 84747 unc-119 lipid binding chaperone B [Source:HGNC Symbol;Acc:HGNC:16488] 4.0 2 449 VPS37C 55048 VPS37C, ESCRT-I subunit [Source:HGNC Symbol;Acc:HGNC:26097] 4.0 2

450 LYL1 4066 lymphoblastic leukemia associated hematopoiesis regulator 1 [Source:HGNC Symbol;Acc:HGNC:6734] 4.0 2 451 ERAP2 64167 endoplasmic reticulum aminopeptidase 2 [Source:HGNC Symbol;Acc:HGNC:29499] 4.0 2 452 IKZF1 10320 IKAROS family zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:13176] 3.9 2 453 SELL 6402 selectin L [Source:HGNC Symbol;Acc:HGNC:10720] 3.9 2 454 CBR4 84869 carbonyl reductase 4 [Source:HGNC Symbol;Acc:HGNC:25891] 3.9 2 455 CMTM2 146225 CKLF like MARVEL transmembrane domain containing 2 [Source:HGNC Symbol;Acc:HGNC:19173] 3.9 2 456 NAA50 80218 N(alpha)-acetyltransferase 50, NatE catalytic subunit [Source:HGNC Symbol;Acc:HGNC:29533] 3.9 2 457 LAMTOR5 10542 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 [Source:HGNC Symbol;Acc:HGNC:17955] 3.9 2 458 CCDC86 79080 coiled-coil domain containing 86 [Source:HGNC Symbol;Acc:HGNC:28359] 3.9 2 459 HDAC3 8841 histone deacetylase 3 [Source:HGNC Symbol;Acc:HGNC:4854] 3.9 2 460 NPFFR2 10886 neuropeptide FF receptor 2 [Source:HGNC Symbol;Acc:HGNC:4525] 3.9 2 461 MLH3 27030 mutl homolog 3 [Source:HGNC Symbol;Acc:HGNC:7128] 3.9 2 462 CCDC53 51019 coiled-coil domain containing 53 [Source:HGNC Symbol;Acc:HGNC:24256] 3.9 2 463 GRB10 2887 growth factor receptor bound protein 10 [Source:HGNC Symbol;Acc:HGNC:4564] 3.9 2 464 EHD3 30845 EH domain containing 3 [Source:HGNC Symbol;Acc:HGNC:3244] 3.9 2 465 PREX1 57580 phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 [Source:HGNC Symbol;Acc:HGNC:32594] 3.9 2 466 GP6 51206 glycoprotein VI platelet [Source:HGNC Symbol;Acc:HGNC:14388] 3.9 2 467 HBS1L 10767 HBS1 like translational GTPase [Source:HGNC Symbol;Acc:HGNC:4834] 3.9 2 468 HIPK2 28996 homeodomain interacting protein kinase 2 [Source:HGNC Symbol;Acc:HGNC:14402] 3.9 2 469 CBR1 873 carbonyl reductase 1 [Source:HGNC Symbol;Acc:HGNC:1548] 3.9 2 470 BAZ1B 9031 bromodomain adjacent to zinc finger domain 1B [Source:HGNC Symbol;Acc:HGNC:961] 3.9 2 471 SMIM15 643155 small integral membrane protein 15 [Source:HGNC Symbol;Acc:HGNC:33861] 3.9 2 472 UBE2K 3093 ubiquitin conjugating enzyme E2 K [Source:HGNC Symbol;Acc:HGNC:4914] 3.9 2 473 PPFIA1 8500 PTPRF interacting protein alpha 1 [Source:HGNC Symbol;Acc:HGNC:9245] 3.9 2 474 MAP2K3 5606 mitogen-activated protein kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6843] 3.9 2 475 PREPL 9581 prolyl endopeptidase-like [Source:HGNC Symbol;Acc:HGNC:30228] 3.9 2 476 ARHGAP9 64333 Rho GTPase activating protein 9 [Source:HGNC Symbol;Acc:HGNC:14130] 3.9 2 477 OCIAD2 132299 OCIA domain containing 2 [Source:HGNC Symbol;Acc:HGNC:28685] 3.9 2 478 BRD9 65980 bromodomain containing 9 [Source:HGNC Symbol;Acc:HGNC:25818] 3.9 2 479 NUDT5 11164 nudix hydrolase 5 [Source:HGNC Symbol;Acc:HGNC:8052] 3.9 2 480 DEPDC1B 55789 DEP domain containing 1B [Source:HGNC Symbol;Acc:HGNC:24902] 3.9 2 481 TNFRSF10C 8794 tumor necrosis factor receptor superfamily member 10c [Source:HGNC Symbol;Acc:HGNC:11906] 3.9 2 482 CT45A1 541466 cancer/testis antigen family 45, member A1 [Source:HGNC Symbol;Acc:HGNC:33267] 3.9 2 483 PIM3 415116 Pim-3 proto-oncogene, serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:19310] 3.9 2 484 SLC24A4 123041 solute carrier family 24 member 4 [Source:HGNC Symbol;Acc:HGNC:10978] 3.9 2 485 TCERG1 10915 transcription elongation regulator 1 [Source:HGNC Symbol;Acc:HGNC:15630] 3.9 2 486 HCAR3 8843 hydroxycarboxylic acid receptor 3 [Source:HGNC Symbol;Acc:HGNC:16824] 3.9 2 487 UBP1 7342 upstream binding protein 1 (LBP-1a) [Source:HGNC Symbol;Acc:HGNC:12507] 3.9 2 488 BET1 10282 Bet1 golgi vesicular membrane trafficking protein [Source:HGNC Symbol;Acc:HGNC:14562] 3.9 2 489 GAB1 2549 GRB2 associated binding protein 1 [Source:HGNC Symbol;Acc:HGNC:4066] 3.9 2 490 ATG16L2 89849 autophagy related 16 like 2 [Source:HGNC Symbol;Acc:HGNC:25464] 3.9 2 491 GSK3B 2932 glycogen synthase kinase 3 beta [Source:HGNC Symbol;Acc:HGNC:4617] 3.9 2 492 IQSEC1 9922 IQ motif and Sec7 domain 1 [Source:HGNC Symbol;Acc:HGNC:29112] 3.9 2 493 CAV2 858 caveolin 2 [Source:HGNC Symbol;Acc:HGNC:1528] 3.9 2 494 DNM3 26052 dynamin 3 [Source:HGNC Symbol;Acc:HGNC:29125] 3.9 2 495 BIN2 51411 bridging integrator 2 [Source:HGNC Symbol;Acc:HGNC:1053] 3.9 2 496 IL6R 3570 interleukin 6 receptor [Source:HGNC Symbol;Acc:HGNC:6019] 3.8 2 497 VPS13A 23230 vacuolar protein sorting 13 homolog A [Source:HGNC Symbol;Acc:HGNC:1908] 3.8 2 498 EIF5A 1984 eukaryotic translation initiation factor 5A [Source:HGNC Symbol;Acc:HGNC:3300] 3.8 2 499 NUFIP2 57532 NUFIP2, FMR1 interacting protein 2 [Source:HGNC Symbol;Acc:HGNC:17634] 3.8 2 500 PNRC2 55629 proline rich nuclear receptor coactivator 2 [Source:HGNC Symbol;Acc:HGNC:23158] 3.8 2 501 SMOX 54498 spermine oxidase [Source:HGNC Symbol;Acc:HGNC:15862] 3.8 2 502 G6PD 2539 glucose-6-phosphate dehydrogenase [Source:HGNC Symbol;Acc:HGNC:4057] 3.8 2 503 TWISTNB 221830 TWIST neighbor [Source:HGNC Symbol;Acc:HGNC:18027] 3.8 2 504 MLXIP 22877 MLX interacting protein [Source:HGNC Symbol;Acc:HGNC:17055] 3.8 2 505 DCAF5 8816 DDB1 and CUL4 associated factor 5 [Source:HGNC Symbol;Acc:HGNC:20224] 3.8 2 506 DDX19A 55308 DEAD-box helicase 19A [Source:HGNC Symbol;Acc:HGNC:25628] 3.8 2 507 MYO1F 4542 myosin IF [Source:HGNC Symbol;Acc:HGNC:7600] 3.8 2 508 MRPL43 84545 mitochondrial ribosomal protein L43 [Source:HGNC Symbol;Acc:HGNC:14517] 3.8 2 509 C6orf25 80739 chromosome 6 open reading frame 25 [Source:HGNC Symbol;Acc:HGNC:13937] 3.8 2 510 TMEM147 10430 transmembrane protein 147 [Source:HGNC Symbol;Acc:HGNC:30414] 3.8 2 511 BCAS3 54828 breast carcinoma amplified sequence 3 [Source:HGNC Symbol;Acc:HGNC:14347] 3.8 2 512 TRIB1 10221 tribbles pseudokinase 1 [Source:HGNC Symbol;Acc:HGNC:16891] 3.8 2 513 KIF2A 3796 kinesin heavy chain member 2A [Source:HGNC Symbol;Acc:HGNC:6318] 3.8 2 514 TGFB1 7040 transforming growth factor beta 1 [Source:HGNC Symbol;Acc:HGNC:11766] 3.8 2 515 SUPT16H 11198 SPT16 homolog, facilitates chromatin remodeling subunit [Source:HGNC Symbol;Acc:HGNC:11465] 3.8 2 516 ERP44 23071 endoplasmic reticulum protein 44 [Source:HGNC Symbol;Acc:HGNC:18311] 3.8 2 517 MYZAP 100820829 myocardial zonula adherens protein [Source:HGNC Symbol;Acc:HGNC:43444] 3.8 2 518 ARID1A 8289 AT-rich interaction domain 1A [Source:HGNC Symbol;Acc:HGNC:11110] 3.8 2 519 TIMM10 26519 translocase of inner mitochondrial membrane 10 homolog (yeast) [Source:HGNC Symbol;Acc:HGNC:11814] 3.8 2 520 TRAPPC6B 122553 trafficking protein particle complex 6B [Source:HGNC Symbol;Acc:HGNC:23066] 3.8 2 521 NOP16 51491 NOP16 nucleolar protein [Source:HGNC Symbol;Acc:HGNC:26934] 3.8 2 522 CD96 10225 CD96 molecule [Source:HGNC Symbol;Acc:HGNC:16892] 3.8 2 523 HAL 3034 histidine ammonia-lyase [Source:HGNC Symbol;Acc:HGNC:4806] 3.8 2 524 SSX2 6757 SSX family member 2 [Source:HGNC Symbol;Acc:HGNC:11336] 3.8 2