Research Progress in Papaverine Determination

Transcript

1 PROGRESS IN CHEMISTRY Vol. 17 No. 5 Sep., ( ),,,, : O65 ; R : A : X(2005) Research Progress in Papaverine Determination Yan Jin Zhao Meiping 3 3 Li Yuanzong Chang Wenbao ( Institute of Analytical Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing , China) Abstract Being commonly used in clinical treatment and illegally used as additive in food products, papaverine and pericarpium papaveris have attracted many researchers to establish reliable determination methods. The structural characters and clinical use of papaverine and pericarpium papaveris are systematically summarized. Introduction and evaluation of related determination methods, including chemical analysis, spectral analysis, electrochemistry, chromatographic techniques, electrophoresis and immunoassay method are presented. The developing trend of papaverine determination is also proposed. Key words papaverine ; pericarpium papaveris ; determination (12[ (3,42 ) ]26,72 ), 1848,Merck [1 ] The structure of papaverine C 20 H 21 NO 4 Goldschmiedt [2 ] 1883, 1888 ( 1 %), ( ), Pictet Gams [1 ] 1909,, : , : (No. 2001BA804A21) 3 3 e2mail : edu. cn

2 898 17,, 011 molπl [3, ], [ 4], 2., 5 %,, 5 %,,, mgΠkg Papaver somniferum L.,, 1. [4, ],,, Abdel2Ghani [6 ], chromotrope 2B, (C2B) chromotrope 2R(C2R), 4 (C2B, nm, C2R nm), ( ) 9918 % ( ) %,, El2Zeany [7 ] 54 %, 90 %,, 015 2h, 24h 310nm, 287nm 42, Vierordt, 100 % [8 ] 2 %, : [ 5] 1.,, 92 %,, 87 %, Mirzaeva [9 ] Dimedrol ( ), Sulfonazo,, (5 3)

3 nm (CL) Dimedrol, 9615 % 9715 % Zhuang [13 ] 2., : [10, ] - - HSO 3 + MnO HSO 3 S 2 O 6 + 2H +, Tris2HCl S 2 O 6 SO 4 + SO 2 252nm 3 SO 2 SO 2 + h, 500nm, molπl, ; molπl (3S),RSD 210 %, 2,,, OH, 2,, Zhang [14 ], ( ), 2, 2 ( ),, molπl, 1210ngΠmL [11, ], (BSA),, ( ) BSA, molπl, BSA ,RSD 210 %, 87nmolΠL (3, ) Baudot [12 ] 3 4., Eisman [15 ] (AAS) HSO 3 + MnO 4 ( ) 360nm, ( ) Reinecke AAS 150 h - 1,, 5 85mgΠmL 50, 850mgΠmL,RSD 113 % 312 %,,

4 900 17,,, [16 ], NH 3 2NH 4 Cl TLC,,, Rajananda [20 ] TLC, Frumkin, : TLC, TLC Szabo [22 ] TLC,, HPTLC, molπl, molπl Yegorov [17 ] PVC 25 % ( ,vΠv) ; ( ,vΠv) [18 ; Dragendorff ph ] Marquis 600nm 520nm [23 ] 2 (9 1,vΠv) molπl, G, molπl 2, [19, 9910 % % ], 4 gπl ( g ΠL ) A 1 B 1 PVC TLC HPTLC ( molπl, molπl ),, 98 % 103 %,RSD 2. ( GC) 314 % GC, GC, GC 1. ( TLC) ( HPTLC) TLC HPTLC [21 ] GS2910 GF 254, 2 (4 1) 5, %, %, (FID)

5 5 901 [24 ] 115 %OV217, molπl ( mgΠmL, R, FID = ), 50ng (3 SΠN) 01444, 1111 gπml Kikura2Hanajiri [39 ] (APCI2MS) % % [25 ] 0153mm ( HP21 M3G ), FID, ODS23,, 3 8 ( ) g 4 Bakkali [32 ] 160 gπml, 0150 gπml 72h 3 (SPE), C 18 [26 ] GC2FID ( 212nm) 4 4, ( ) 80 % Doner [36 ],, HP25,, HPLC molΠL KH 2 PO 4 (75 25, vπ v) 286nm Paul [27 ] GC, 16min, 014ngΠmL, HPLC, 67 gπg, 0117 gπg, GC 3. ( HPLC) HPLC TLC HPTLC HPLC HPLC, 10,HPLC, HPLC, GC, HPLC [28 ] [29 34 ] [35, 36 ] [37, 38 ] 4., (CE) HPLC,, [30 ] C 18, CH 3 OH225mmolΠL KH 2 PO 4 (90 10,vΠv), (254nm, ), (CZE) (MEKC), 3, 011 gπml Borojevic [33 ] [40 C 18 2 ] MEKC, 62 8 ;

6 902 17, 10mmol 25mmol SDS 10 % (vπv) (ph ),8, mgΠL Bjgrnsdottir [41 ] CE, DMF DMSO, (25mmolΠL)2 (1molΠL) [45, 46, 25 % 2 ] [47 ], 25, [48 ], (DAD), 214nm, [42 ] Yeremenko [49 ] 1992 MEKC, 5, ( ELISA) 62 (0105molΠL,pH = 410), 32 2, ( 220 SDS) 5 (BSA) ELISA (CD) : (25mmolΠL mmolΠL SDS) ( HRP) ;,,, 1 gπml ; [50 ] CD,, Yeremenko 30mmolΠL DM2 2CD, ELISA Reddy [43 ] CZE 5, ; ph 3,,, 215 % 3 ( = 3), 450ngΠmL ( ) 500ngΠmL ( ) 550ngΠmL,6,72 ( ) 500ngΠmL ( ) RSD RSD 1103 % 3156 % 0134 % 0169 %, 0192 % [ % ] [44 ] HPCE, BSA 3, : 50mmolΠmL 6,72 (ph = 710) ;,9min 3 1 ( ), ;, % ;, 1 % HPLC,CE 2

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