Progress on Joint Effect of Mixture Pollutants

Transcript

1 Environmental Science & Technology Vol. 32 No.2 Feb * TU AI MTI λ TU λ - QSAR QSAR M-QSAR 21 QSAR X174 A (2009) Progress on Joint Effect of Mixture Pollutants ZENG Ming 1 4 LIN Zhi-fen 1 2 3* YIN Da-qiang 2 YIN Ke-dong 1 1.Key Laboratory of Tropical Marine Environmental Dynamics South China Sea Institute of Oceanology Chinese Academy of Sciences Guangzhou China 2.Key Laboratory of Yangtze River Water Environment of Ministry of Education School of Environment Science and Engineering Tongji University Shanghai China 3.State Key Laboratory of Marine Environmental Science School of Environment Science Xiamen University Xiamen China 4.Graduate School Chinese Academy of Sciences Beijing China Abstract Environmental pollutants are almost mixtures. Advances on joint toxicological effect of mixture pollutants were reviewed according to development of various stages. Methods from qualitative to quantitative study of joint toxicological effect together with disadvantages and advantages were systematically introduced with focus on qualitative study and development of quantitative study. M -QSAR which draws lessons from QSAR of individual chemicals is still at primary stage, but is prospective for sustainable development in 21st century which can not only facilitate the development of environmental pollution chemistry but provide more reliable scientific approaches and theory basis to estimate ecology risk of pollutant. Key words mixture pollutant joint toxicological effect QSAR advance [5] [6] 50 AI MTI λ [7] [1] 1939 [2] [8] [3-4] 70 TU J1-C0241 YRWEF07004 MEL zmrainbow@yahoo.com.cn * lzhifen@scsio.ac.cn

2 2 81 TU [9] λ [10] TU M-QSAR [11] M- 1.2 AI QSAR AI TU 1977 Marking [5] M=1 AI=M-1 M>1 AI=-M+1 1 M= TU i Bliss [2] 2 AI=0 AI<0 AI>0 [12] AI TU M TU AI MTI λ 1.1 TU TU TU TU AI 1965 Sprague [3] Cu-Zn [18] Cu 2+ Zn 2+ Cd Anderson [4] Cu 2+ Zn 2+ Zn 2+ Cd 2+ TU i = C i IC 50i 1 C i i 1 M<1 AI=1/M-1 AI Cu 2+ Zn 2+ Cd 2+ [19] AI 0.03 IC 50i i [13] IC 50 LC 50 AI 6.30~20.74 TU=1 TU= TU i [20] TU>TU 0 TU 0 = TU max TU i [20] [21] [22] [23] TU<1 [24] [25] TU=TU 0 TU 0 >TU> 1 AI TU TU [26] [14] 2 4- [27] 5 SDS TU [15] 0.79~1.46 AI [24] TU 0.99 ChungYuan Chen [16] AI TU TU AI [17] DNT 1.3 MTI TU DNT MTI

3 82 32 K 觟 nemann [6] 1981 MTI MTI = logm 0- logm 3 Prakash [10] logm 0 M 3 M= TU i M 0 = max ( TU i ) Polybac 3 λ 1.06 MTI<0 MTI=0 λ 0<MTI< [27] MTI=1 λ 0.21 MTI>1 SDS λ Koutsaftis [28] λ AI [32] MTI 1.972~ MTI ~ Wolf [29] 25 MTI 0.921~0.988 J.Chen [30] [10] λ 13 2 MTI 0.16~0.98 AI MTI [31] TU AI MTI MTI AI AI AI 12.51~ TU AI 6.30~9.20 MTI Nirmalakhanda [9] : 4 4: 1 n MTI 9.91~11.19 MTI [17] 4.76~ n TU i = n TU 5 QSAR AI 2 4-DNT IC 50i AI AI 0.667~3.065 MTI 2 4-DNT MTI C i = IC 50i n MTI 4.254~7.445 Xu [33] λ n-1 λ Christense [7] 1989 n n 6 n - 1 C n = IC 50, n 1 - TU i 6 m 2.2 λ TU i 1 / λ = 1 4 Prakash [10] 1996 Christense [7] 4 λ λ=1 λ>1 1>λ>0

4 2 83 m I Σ ( TU i ) ( 1 / λ) 50M = 1 7 K MD 7 M-QSAR Prakash M -QSAR λ 10 M-QSAR 11 Prakash Nirmalakhanda Xu log1 / EC 50M = *logK MD *log ( 1 / I 50M ) 10 n=14 r 2 =0.892 SE= F= P=0.000 log1 / EC 50M = logK MD M-QSAR log ( 1 / I 50M ) M-QSAR n=10 r 2 =0.897 SE=0.294 F= P= QSAR [34] M-QSAR 2007 Zhang [57] [46 51] lgenr M GAP h-1m q M- GAPV mm QSAR M-QSAR 2000 [ ] - 12 QSAR M-QSAR 13 / K ow log1/ec 50M =34.828q M lgEnr M αh βh GAP h - 1M K MD R 2 (adj.)=0.906 F= SE= n=28 P=0.000 A MH B MH I 50M log1/ec 50M =4.622lgEnr M GAP h -1M M- GAPV mm μ QSAR R 2 (adj.)=0.850 F= SE= n=50 P= K MD 3 M-QSAR 8 log1 / EC 50M = logK MD n=134 r 2 =0.964 SE= F= P=0.000 M-QSAR - QSAR M-QSAR - M-QSAR 2 K MD M-QSAR M-QSAR A MH B MH M-QSAR 9 log1 / EC 50M = lgK MD A MH + M- QSAR B MH 9 n=35 r 2 =0.955 SE= F= P=0.000 M- A MH B MH QSAR M-QSAR 3

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