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4 " 251# 6JOF!'#`6JOF # 04&`04 MDAHA 6JOFEIJDA@EBBAHA?A>AJMAA6JOF=JJDA"# JD EBANAH?EIAEKIFHAANAH?EIA 6JOF6JOF 04EIJDA@EBBAHA?A>AJMAA04=JJDA"# JD EBANAH?EIAEKIFHAANAH?EIA J=JEIJE?I,=J==HAFHAIAJA@=IA=I5-KAIIJDAHMEIAIJ=JA@6DAABBA?JIB0,*4=@ JH=EECJDAHHACK=JHOHAIFIAIJANAH?EIAMAHAJAIJA@>OJMM=O)8)BHHAFA=JA@ A=IKHAI5K>IAGKAJFIJD?F=EHMEIA?F=HEIIMAHAFAHBHA@KIECJDA5JK@AJJJAIJ6DA KDOFJDAIEIM=IHAA?JA@MDAF#.H?=?K=JEIJDA5J=JEIJE?= LAHIE$5J=JIBJ 1?6KI=75)M=IKIA@ =I=LKA@A?HA=IA@IECEBE?=JOF@KHEC>JD0,*4FAHE@I >O#=@'%=BJAH0,*4=@0,*4 HAIFA?JELAO 6H=EECE?HA=IA@8 =N>O BH!!'J!&E F,KHEC=ANAH?EIAJAFAH=JKHAJAIJIJDAA=ANAH?EIA=@M=I"% "9MDE?D?HHAIF@A@J$!!=@# %B8 =N@AJAHEA@ >ABHA=@=BJAHJH=EECHAIFA?JELAO)=OIEIBL=HE=?A@E@JHALA= IECEBE?=J@EBBAHA?AI>AJMAAJDAJAIJIE8 HAIFEH=JHOAN?D=CAH=JE=@ DA=JFH@K?JEMDEAANAH?EIA04@A?HA=IA@FBMECJH=EEC=@ E?HA=IA@F=BJAH>JD0,*4FAHE@I6DAL=KAIBJDAIAL=HE=>AIE JDA=IJEBANAH?EIA=HACELAE6=>A 6=>A 0A=HJH=JA04NOCAKFJ=A8 HAIFEH=JHOAN?D=CAH=JE4-4=@DA=J FH@K?JEA=IKHA@=JJDAA@BANAH?EIAJAIJ=@ANAH?EIAE@K?A@?D=CAIEJOF=E? JAFAH=JKHA 6JOFA=IEJAFAH=JKHA A=6I=@>@O=II >@O=IIMEJD IEDA=J?@K?J=?A0I=@FDOIECE?=IJH=EE@AN251 8=HE=>A *ABHA0,*4 )BJAH0,*4 *ABHA0,*4 )BJAH0,*4 04E #$ # $&$ " # #!#VV 8 E "% "& ' % '!$ 4-4 ' '# ' '! 0A=JFH@K?JE E C #% #% #! #" 6JOF+ %! %& #&% &$VV A=6I+! $! # " "!V >@O=IIC $%!# $$" #%&! #%$! 0I D + "" %'! $" # 251 #! $ "# #" VV 8=KAI=HAA=I5-)IJAHEII@AJAIECEBE?=J@EBBAHA?AIE?F=HEIMEJDJDAJAIJ>ABHA 0,*4F#FF+HIIAI@AJAIECEBE?=J@EBBAHA?AIE?F=HEI MEJDJDAJAIJ>ABHA0,*4 VF#VVF

5 # ` "#EB F#=@@KHECANAH?EIAFE?F=HEIMEJDJDA?JHJAIJMDEA =BJAH0,*4 +F=HEIB6JOFEJDAFHA0,*4JAIJI>ABHA=@=BJAHJH=EEC@E@J 6JOFM=ICHA=JAHF =BJAHJD=>ABHA0,*4 6=>A BANAH?EIAJDAA=6IM=IMAHE?F=HEIMEJDJDAHAIJECL=KAIE HAIFA?JELAO)=OIEIBL=HE=?A@E@JHALA=IECEBE?=JABBA?JIBJH=EEC MAHL=KAIM=IJA@=BJAH>JD0,*4FAHE@IE?F=HEIMEJDJDA HAIFA?JELAFHA0,*4JAIJI9EJDEJDA=IJ #EBANAH?EIAJDAA=6I M=IMAHF#=BJAH0,*4 6I@EBBAHA@IECEBE?=JO>AJMAAJDAFHA=@FIJ 0,*4JAIJI6=>A Tympanic temperature ( o C) before HDBR1 after HDBR1 before HDBR2 after HDBR2 * * * * * Mean skin temparature ( o C) Time (min).ec6ea?khiab?d=caie JOF=E?=@A=IE JAFAH=JKHAI@KHECJDABKH ANAH?EIAJAIJI)IJAHEII@AJA IECEBE?=J@EBBAHA?AI>AJMAA L=KAI>J=EA@>ABHA=@=BJAH 0,*4F#F

6 $ ABJF=A IECEBE?=JODECDAHF#=BJAHJD=>ABHA0,*4MDEAJDAIFAIBJDA HECDJ F=A6H=EECH0,*4 8=HE=>A *ABHA0,*4 )BJAH0,*4 *ABHA0,*4 )BJAH0,*4 5MA=JECIAJI & '!&!! &%!!#!# τ I $%!% ""!"! $ " 5MA=JECJDHAID@+!%&&!%!$!%&!%& 8=KAI=HAA=I5-)IJAHEI@AJAIIECEBE?=J@EBBAHA?AE?F=HEIMEJDJDAJAIJ>ABHA 0,*4F# Local sweating rate (mg/cm 2 /min) Time (min) before HDBR1 after HDBR1 before HDBR2 after HDBR (mg/cm 2 /min) * Tympanic temperature ( o C).EC 6EA?KHIAB?=?DAIJIMA=JH=JA@KHECANAH?EIAABJF=A=@HA=JEIDEF>AJMAA

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