Supplementary Materials for
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- Δάφνη Σπηλιωτόπουλος
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1 Supplementary Materials for Therapeutic targeting of casein kinase 1 in breast cancer Laura H. Rosenberg, Marie Lafitte, Victor Quereda, Wayne Grant, Weimin Chen, Mathieu Bibian, Yoshihiko Noguchi, Mohammad Fallahi, Chunying Yang, Jenny C. Chang, William R. Roush, John L. Cleveland, Derek R. Duckett* The PDF file includes: *Corresponding author. ducketdr@scripps.edu Published 16 December 2015, Sci. Transl. Med. 7, 318ra202 (2015) DOI: /scitranslmed.aac8773 Fig. S1. CK1δ, but not CK1ε, is overexpressed in human breast cancer and associated with CSNK1D gene amplification. Fig. S2. CK1δ is overexpressed in human breast cancer specimens. Fig. S3. Silencing of CK1δ and CK1ε, but not CK1ε alone, impairs growth and survival of MDA-MB-231 breast cancer cells. Fig. S4. Selective inhibition of FLT3 has no effect on proliferation of MDA-MB- 231 breast cancer cells. Fig. S5. Treatment with SR-3029 impairs growth of triple-negative and HER2 + breast tumor models. Fig. S6. Long-term daily dosing with SR-3029 has no adverse effects on major organ histology. Fig. S7. Selective silencing of CK1δ is sufficient to impair growth of MDA-MB- 231 breast cancer cells. Fig. S8. Wnt/β-catenin pathway genes are a hallmark of CK1δ-expressing breast cancers. Fig. S9. Constitutively active β-catenin N90 rescues the growth inhibitory effects of CK1δ inhibition and silencing. Fig. S10. CK1δ expression in MCF7 breast cancer cells sensitizes them to SR Fig. S11. Cyclin D1 expression is suppressed in TNBC MDA-MB-231 derived tumors after knockdown of CK1δ. Fig. S12. Inhibition of CK1δ/CK1ε has no effect on intestinal homeostasis. Fig. S13. Canonical Wnt signaling genes are correlated with CK1δ expression in human renal and bladder cancer.
2 Table S1. TCGA RNA-seq and GISTIC2 copy number data and correlation analysis for breast cancer (BRCA) tumors. Table S2. TCGA RNA-seq and GISTIC2 copy number data for basal-like Pam50 breast tumors. Table S3. TCGA RNA-seq and GISTIC2 copy number data for HER2-positive Pam50 breast tumors. Table S4. TCGA RNA-seq and GISTIC2 copy number data for luminal A Pam50 breast tumors. Table S5. TCGA RNA-seq and GISTIC2 copy number data for luminal B Pam50 breast tumors. Table S6. Potency of the CK1δ/CK1ε inhibitor SR-3029 for human breast cancer subtypes. Table S7. No toxic effects from long-term daily treatment with SR Table S8. TCGA RNA-seq and GISTIC2 copy number data for renal papillary (KIRP) tumors. Table S9. TCGA RNA-seq and GISTIC2 copy number data for bladder cancer (BLCA) tumors. Table S10. Renal papillary cell carcinoma correlation analysis. Table S11. Bladder cancer correlation analysis. Table S12. Wnt signaling genes significantly associated with CK1δ expression in renal papillary cell carcinoma. Table S13. Wnt signaling genes significantly associated with CK1δ expression in bladder cancer. Table S14. Oligonucleotides used for qpcr. Table S15. sirna sequences. Table S16. shrna sequences.
3 Supplementary Figures Fig. S1. CK1δ, but not CK1ε, is overexpressed in human breast cancer and associated with CSNK1D gene amplification. (A) CK1δ expression in 53 invasive breast carcinomas vs. normal breast tissue analyzed with Oncomine (14). (B) CK1ε expression in 392 invasive breast carcinomas (TCGA) vs. normal breast tissue analyzed with Oncomine. (C) Proportional frequency of CSNK1D copy number amplifications (high and low) by breast cancer subtype (TGCA; Basal, n=135, HER2+, n=67, Luminal A, n=413, Luminal B, n=192). (D) Scatter plots of
4 CSNK1D Log2 mrna expression vs. Log2 copy number values for each of the major Pam50 breast cancer subtypes.
5 Fig. S2. CK1δ is overexpressed in human breast cancer specimens. Immunohistochemical staining for CK1δ in normal breast tissue (top panels) and human breast carcinoma specimens (bottom panels) ( Nine out of the eleven tumors analyzed showed high expression of CK1δ. One representative core is shown for each patient s tumor (scale bar=400 μm).
6 Fig. S3. Silencing of CK1δ and CK1ε, but not CK1ε alone, impairs growth and survival of MDA- MB-231 breast cancer cells. (A) Immunoblot and qpcr analyses showing knockdown of CK1δ and CK1ε in MDA-MB-231 cells after transfection with either non-targeting (NT) sirnas or sirnas directed against both CK1δ and CK1ε (n=3; **, p=0.01). (B) Percentage of apoptotic cells
7 (left) measured by trypan blue exclusion (n=3; ***, p=0.0002) and relative growth (right) (n=3; ***, p=0.0003) 3 days after sirna transfection. (C) MDA-MB-231 cells were transiently transfected with expression vectors containing sirna-resistant cdna of either CK1δ or GFP 24 hours before transfection with sirnas. 3 days later, CK1δ expression was analyzed by immunoblot (top panel), and relative cell growth was determined by counting (bottom panel). (D) Selective knockdown of CK1ε in MDA-MB-231 cells after transfection with non-targeting (NT) sirnas or sirnas against CK1ε (n=3; ***, p<0.0001). (E) Percentage of apoptotic cells (left) and relative growth (right) 3 days after sirna transfection (n=3; ***, p<0.0001).
8 % DMSO Control EC 50 [M] SR e-008 SR e AC220 SR-2890 SR [M] Compound Fig. S4. Selective inhibition of FLT3 has no effect on proliferation of MDA-MB-231 breast cancer cells. Comparison of the anti-proliferative potency of AC220 (a FLT3 inhibitor) vs. SR and SR1277 (close analogs of SR-3029) on MDA-MB-231 breast cancer cells. Data are plotted as % proliferation vs. vehicle (DMSO control) (n=3).
9 Fig. S5. Treatment with SR-3029 impairs growth of triple-negative and HER2 + breast tumor models. (A) Left, Caliper measurements of MDA-MB-231 tumor size in mice treated with vehicle or SR Treatment began at day 30 (20 mg/kg/day i.p.). Mean tumor volumes are shown for each cohort at day 35 vs. day 61, which demonstrates significant tumor regression (n=7 mice per cohort; **, p=0.01). Right, treatment of MDA-MB-468 tumors (20 mg/kg/day i.p.) began at day 42 after implantation (20 mg/kg/day i.p.). Graph shows mean tumor volume at day 42 vs. day 64 (n=8-9; ***, p=0.0006). (B) Caliper measurements of SKBR3 tumor growth in mice treated with vehicle or SR Treatment began at day 60 (20 mg/kg/day i.p.) and was terminated at day 96 due to the hemorrhagic nature of the vehicle-treated tumors.
10 Fig. S6. Long-term daily dosing with SR-3029 has no adverse effects on major organ histology. Mice were treated with vehicle or SR-3029 for 48 days (once daily, 20 mg/kg i.p.). The indicated tissues were then examined by H&E staining (representative images are shown, scale bar 200 microns).
11 Fig. S7. Selective silencing of CK1δ is sufficient to impair growth of MDA-MB-231 breast cancer cells. MDA-MB-231 cells expressing Dox-inducible non-targeting (NT) or CK1δ shrna were treated with 1 µg/ml Dox for 72 hours before transfection with CK1δ or GFP cdnaexpressing vectors resistant to shrna. After an additional 72 hours, CK1δ expression was analyzed by immunoblot (top panel), and relative cell growth was determined by counting (bottom panel) (n=4; **, p= 0.009).
12 Fig. S8. Wnt/β-catenin pathway genes are a hallmark of CK1δ-expressing breast cancers. (A) Heatmap of the CK1δ signature list (612 genes) in TCGA RNA-Seq breast cancer dataset. (B) Volcano Plot function showing differentially expressed genes in CK1δ-high versus CK1δ-low expressing tumors (from TCGA RNA-Seq breast cancer dataset). Corrected p value cut-off was
13 set to 0.05 and fold change cut-off was set to 2 to identify hits (red dots). (C) Wnt pathway genes differentially expressed (fold change) between CK1δ-high and CK1δ-low groups.
14 Fig. S9. Constitutively active β-catenin N90 rescues the growth-inhibitory effects of CK1δ inhibition and silencing. (A) MDA-MB-231 cells stably expressing the N90 β-catenin mutant or parental MDA-MB-231 cells were treated with or without 30 nm SR-3029 for 48 hours. Effects on cell growth (left) and apoptosis (right) were determined (n=3; *, p=0.02; ***, p=0.003). (B) Expression of nuclear endogenous β-catenin or the N90 β-catenin mutant in cells treated with the indicated concentrations of SR (C) Cell growth (left) and apoptosis (right) were measured after 5 days of Dox treatment (1 µg/ml) of MDA-MB-231-shCK1δ cells expressing the N90 β-catenin mutant or vector only MDA-MB-231 shck1δ cells (n=3; left to right, *** p= and ).
15 Fig. S10. CK1δ expression in MCF7 breast cancer cells sensitizes them to SR (A) Immunoblot showing relative expression of nuclear and cytoplasmic β-catenin in MDA-MB-231 vs. MCF7 cells. Experiment shown is representative of 3 independent experiments. (B) Growth of MCF7-CK1δ vs. MCF7-GFP cells measured over 72 hours with the indicated concentrations of SR-3029 (n=3; **, p=0.01; ***, p=0.005).
16 Fig. S11. Cyclin D1 expression is suppressed in TNBC MDA-MB-231 derived tumors after knockdown of CK1δ. (A) qpcr showing CK1δ knockdown and reduced Cyclin D1 mrna expression in MDA-MB-231-derived tumors after 7 days of Dox (administered ad lib in chow, 200 mg/kg) (n=3 mice; *, p= ***, p=0.003). (B) Left, down-regulation of Cyclin D1 protein after knockdown of CK1δ in MDA-MB-231-derived tumors from mice treated as above. Right, quantification of B, normalized to GAPDH (*, p=0.028).
17 A Vehicle SR-3029 B DAPI TUNEL Vehicle SR-3029 Fig. S12. Inhibition of CK1δ/CK1ε has no effect on intestinal homeostasis. (A) H&E stained small intestine tissue sections and (B) TUNEL staining of cryosections prepared from mice treated with vehicle or SR-3029 (once daily, 20 mg/kg i.p.) for 48 days (representative images are shown; scale bar 200 microns).
18 Fig. S13. Canonical Wnt signaling genes are correlated with CK1δ expression in human renal and bladder cancer. Heatmaps derived from the indicated TCGA RNA-Seq datasets showing expression of Wnt pathway genes in CK1δ-high vs. CK1δ-low tumors.
19 Supplementary Tables Table S1. TCGA RNA-seq and GISTIC2 copy number data and correlation analysis for breast cancer (BRCA) tumors. Case ID CSNK1D (log2 CNV) CSNK1D (log2 RNASeq) TCGA-B6-A1KF TCGA-OL-A5RZ TCGA-E2-A TCGA-AR-A24S TCGA-D8-A1JN TCGA-D8-A13Y TCGA-EW-A1J TCGA-D8-A1JA TCGA-D8-A1JM TCGA-A7-A0D TCGA-AR-A0TY TCGA-B6-A0IG TCGA-E9-A1RF TCGA-GM-A2D TCGA-C8-A1HL TCGA-A8-A07I TCGA-BH-A0DZ TCGA-A8-A09N TCGA-D8-A1XJ TCGA-D8-A1J TCGA-AO-A0J TCGA-PE-A5DD TCGA-C8-A12Z TCGA-D8-A27T TCGA-C8-A26W TCGA-D8-A27V TCGA-B6-A0IE TCGA-E2-A15H TCGA-AN-A0FW TCGA-D8-A1XU TCGA-BH-A0BC TCGA-B6-A0IK TCGA-A8-A08B
20 TCGA-AQ-A54N TCGA-BH-A0EE TCGA-AN-A0FJ TCGA-BH-A18R TCGA-BH-A1EV TCGA-BH-A0B TCGA-AC-A3W TCGA-E2-A TCGA-D8-A27R TCGA-A8-A TCGA-BH-A1EN TCGA-D8-A1XZ TCGA-BH-A1EY TCGA-EW-A1PA TCGA-GM-A2DA TCGA-AO-A03V TCGA-A2-A4RW TCGA-AO-A0J TCGA-BH-A18F TCGA-AN-A0FD TCGA-E9-A1N TCGA-AO-A0JD TCGA-AN-A04A TCGA-BH-A0HP TCGA-B6-A0RV TCGA-AO-A0JM TCGA-AR-A1AN TCGA-A7-A56D TCGA-AC-A3TM TCGA-BH-A18V TCGA-A8-A08G TCGA-EW-A1OV TCGA-AC-A62Y TCGA-AR-A TCGA-AR-A0U TCGA-AC-A3W TCGA-E2-A14T TCGA-AN-A0AS TCGA-AR-A1AR TCGA-D8-A1Y
21 TCGA-E2-A14V TCGA-A8-A TCGA-BH-A0BR TCGA-E2-A2P TCGA-A7-A0CG TCGA-BH-A0E TCGA-C8-A TCGA-AQ-A0Y TCGA-AR-A1AY TCGA-A1-A0SN TCGA-A2-A0D TCGA-BH-A0C TCGA-BH-A5J TCGA-BH-A0B TCGA-A2-A0CV TCGA-E9-A22A TCGA-E2-A TCGA-A8-A0AD TCGA-BH-A0DP TCGA-BH-A1F TCGA-OL-A5S TCGA-C8-A3M TCGA-B6-A0RU TCGA-C8-A TCGA-BH-A18P TCGA-GI-A2C TCGA-E9-A22G TCGA-AC-A3W TCGA-E2-A1LL TCGA-E9-A22D TCGA-A2-A TCGA-E2-A14X TCGA-AC-A2BM TCGA-A2-A0YK TCGA-E9-A1NH TCGA-B6-A0IB TCGA-A2-A0D TCGA-A2-A25A TCGA-AO-A0JL TCGA-A1-A0SK
22 TCGA-BH-A0BA TCGA-E2-A1B TCGA-C8-A12P TCGA-PE-A5DE TCGA-AO-A03N TCGA-A2-A1G TCGA-C8-A26X TCGA-B6-A0IH TCGA-A2-A4RX TCGA-BH-A1EU TCGA-A7-A26F TCGA-AN-A TCGA-AR-A24R TCGA-A2-A3XZ TCGA-E2-A1II TCGA-BH-A TCGA-BH-A0B TCGA-AO-A12D TCGA-AC-A3BB TCGA-E2-A14Z TCGA-D8-A TCGA-A2-A0CR TCGA-BH-A18I TCGA-A7-A26E TCGA-C8-A TCGA-A7-A26H TCGA-E2-A TCGA-BH-A1FH TCGA-B6-A TCGA-A7-A4SE TCGA-GM-A2DD TCGA-E9-A3X TCGA-JL-A3YW TCGA-AC-A23H TCGA-A2-A3XY TCGA-A8-A08I TCGA-A2-A04U TCGA-BH-A18U TCGA-D8-A13Z TCGA-E2-A
23 TCGA-AR-A1AJ TCGA-GM-A2DI TCGA-A7-A4SD TCGA-A2-A0SX TCGA-AN-A0FT TCGA-BH-A0E TCGA-A8-A TCGA-E2-A15G TCGA-A2-A04W TCGA-D8-A TCGA-BH-A0RX TCGA-A2-A0EY TCGA-BH-A0E TCGA-D8-A27N TCGA-E2-A15M TCGA-E2-A1B TCGA-E9-A1NF TCGA-AR-A2LR TCGA-LL-A5YO TCGA-E2-A15E TCGA-AR-A24U TCGA-A8-A08L TCGA-EW-A2FR TCGA-A2-A0EP TCGA-D8-A1XW TCGA-C8-A TCGA-AR-A2LH TCGA-AQ-A04H TCGA-A2-A04X TCGA-E2-A14P TCGA-AN-A0XW TCGA-E2-A TCGA-E2-A1LI TCGA-AQ-A1H TCGA-A8-A TCGA-A2-A4S TCGA-D8-A1JI TCGA-AO-A TCGA-A1-A0SQ TCGA-BH-A28Q
24 TCGA-D8-A1XR TCGA-AC-A23E TCGA-GM-A4E TCGA-GM-A2DN TCGA-A7-A3IZ TCGA-AR-A24N TCGA-E9-A2JT TCGA-A2-A0ER TCGA-E9-A1N TCGA-B6-A0I TCGA-E2-A1LG TCGA-A8-A0A TCGA-E2-A10B TCGA-EW-A1P TCGA-AR-A5QM TCGA-D8-A27E TCGA-B6-A0RQ TCGA-A2-A0T TCGA-A8-A09Q TCGA-AC-A5XS TCGA-BH-A0EA TCGA-A8-A09G TCGA-A2-A4RY TCGA-AR-A1AO TCGA-E2-A15K TCGA-D8-A1XG TCGA-A2-A25C TCGA-EW-A2FS TCGA-E2-A14Q TCGA-E2-A1LE TCGA-AO-A0JI TCGA-EW-A2FW TCGA-A2-A0CS TCGA-AO-A1KO TCGA-BH-A0DX TCGA-AR-A2LQ TCGA-BH-A1FU TCGA-A8-A07U TCGA-BH-A0DL TCGA-D8-A1XO
25 TCGA-A8-A07S TCGA-E2-A14N TCGA-A7-A0CH TCGA-A2-A0ES TCGA-BH-A0BJ TCGA-AO-A12A TCGA-AC-A2QI TCGA-A2-A25F TCGA-E9-A TCGA-A2-A3Y TCGA-A2-A0CQ TCGA-E2-A1IL TCGA-B6-A0IA TCGA-E2-A1L TCGA-GM-A5PX TCGA-BH-A0EI TCGA-AN-A0FS TCGA-A1-A0SI TCGA-E9-A TCGA-AN-A0XP TCGA-AR-A0TV TCGA-BH-A TCGA-E2-A15P TCGA-D8-A1JS TCGA-BH-A0HI TCGA-AR-A2LJ TCGA-A8-A TCGA-BH-A0DO TCGA-A2-A0EM TCGA-E9-A3Q TCGA-E2-A15F TCGA-E2-A1BC TCGA-B6-A0WT TCGA-D8-A27G TCGA-BH-A0BD TCGA-AN-A0FX TCGA-AO-A TCGA-A1-A0SF TCGA-D8-A1XC TCGA-A2-A3KD
26 TCGA-AO-A12G TCGA-D8-A3Z TCGA-AN-A0AT TCGA-BH-A0DQ TCGA-BH-A0H TCGA-E2-A2P TCGA-C8-A1HE TCGA-B6-A TCGA-E9-A1N TCGA-BH-A42U TCGA-A7-A3J TCGA-AN-A03Y TCGA-LL-A5YL TCGA-A8-A09V TCGA-AR-A24M TCGA-AR-A5QQ TCGA-E9-A1R TCGA-A2-A0YI TCGA-B6-A0X TCGA-OL-A5RU TCGA-A8-A0A TCGA-AR-A24W TCGA-A1-A0SE TCGA-BH-A42V TCGA-E2-A15I TCGA-A7-A3IY TCGA-A2-A3KC TCGA-BH-A0BM TCGA-AR-A1AL TCGA-AC-A23C TCGA-BH-A0BQ TCGA-EW-A1PB TCGA-E9-A1RD TCGA-A8-A0A TCGA-A2-A3XW TCGA-B6-A0RO TCGA-AN-A0FF TCGA-A7-A13G TCGA-D8-A1JU TCGA-GM-A2DM
27 TCGA-BH-A18K TCGA-D8-A1XD TCGA-AR-A0TR TCGA-B6-A0IC TCGA-D8-A27L TCGA-AR-A24T TCGA-C8-A TCGA-E2-A TCGA-A2-A4S TCGA-AC-A2FG TCGA-A2-A3XS TCGA-EW-A1P TCGA-A2-A0D TCGA-C8-A TCGA-B6-A0I TCGA-B6-A0X TCGA-E2-A TCGA-B6-A0RT TCGA-B6-A0X TCGA-OL-A5RV TCGA-E9-A TCGA-AO-A0J TCGA-A8-A TCGA-D8-A1XA TCGA-A7-A5ZW TCGA-A7-A TCGA-D8-A27K TCGA-B6-A0IP TCGA-EW-A1J TCGA-C8-A12T TCGA-BH-A0DV TCGA-A8-A TCGA-A1-A0SB TCGA-BH-A0H TCGA-C8-A12Y TCGA-BH-A28O TCGA-E2-A1IK TCGA-AO-A0JF TCGA-A2-A1G TCGA-AO-A12H
28 TCGA-A2-A0YD TCGA-BH-A0DS TCGA-AN-A0XV TCGA-BH-A0BO TCGA-AQ-A04L TCGA-EW-A1P TCGA-B6-A40B TCGA-OL-A5RW TCGA-AC-A3YJ TCGA-BH-A0GZ TCGA-BH-A1FL TCGA-BH-A1FR TCGA-E9-A1RC TCGA-A8-A TCGA-AR-A0TW TCGA-OL-A5RX TCGA-A2-A0T TCGA-B6-A0WS TCGA-EW-A1IX TCGA-AC-A3YI TCGA-D8-A1JH TCGA-GM-A3XG TCGA-EW-A1PE TCGA-OL-A5RY TCGA-A7-A13E TCGA-AR-A24O TCGA-C8-A TCGA-BH-A0B TCGA-AN-A0FK TCGA-D8-A1XV TCGA-BH-A0H TCGA-EW-A1IY TCGA-GM-A2DB TCGA-B6-A0WZ TCGA-D8-A27P TCGA-A7-A3RF TCGA-A8-A TCGA-AC-A3OD TCGA-BH-A1FB TCGA-A2-A1FZ
29 TCGA-E2-A15R TCGA-AR-A1AM TCGA-E2-A1IO TCGA-AO-A TCGA-BH-A0HK TCGA-D8-A4Z TCGA-EW-A2FV TCGA-AO-A TCGA-E9-A1NG TCGA-AR-A TCGA-A2-A0EW TCGA-E2-A1L TCGA-D8-A27I TCGA-E2-A1L TCGA-OK-A5Q TCGA-A2-A0ST TCGA-AN-A0FN TCGA-BH-A0E TCGA-BH-A0W TCGA-OL-A66J TCGA-AC-A2B TCGA-AR-A1AU TCGA-AR-A2LO TCGA-D8-A3Z TCGA-LL-A TCGA-OL-A66I TCGA-A2-A0YJ TCGA-BH-A1F TCGA-D8-A TCGA-BH-A0HO TCGA-E2-A15J TCGA-A8-A08Z TCGA-AC-A2FF TCGA-BH-A0BS TCGA-AR-A2LM TCGA-BH-A0EB TCGA-AO-A03U TCGA-E9-A TCGA-E2-A14U TCGA-GM-A5PV
30 TCGA-A7-A0DB TCGA-D8-A1X TCGA-A8-A09Z TCGA-A2-A0T TCGA-EW-A1IW TCGA-BH-A0W TCGA-A2-A0EO TCGA-OL-A66H TCGA-A2-A0YG TCGA-E9-A TCGA-A8-A TCGA-AC-A2FE TCGA-E9-A1N TCGA-AC-A3QP TCGA-GM-A3XN TCGA-AR-A0TT TCGA-BH-A0DT TCGA-A8-A07J TCGA-BH-A0DH TCGA-A2-A0YL TCGA-E2-A1LH TCGA-E9-A22H TCGA-AO-A03M TCGA-E2-A1IF TCGA-HN-A2OB TCGA-AO-A0JC TCGA-E2-A1IU TCGA-BH-A2L TCGA-BH-A0W TCGA-E9-A24A TCGA-A7-A13H TCGA-LL-A50Y TCGA-E2-A10E TCGA-E9-A5FK TCGA-A8-A07F TCGA-E2-A TCGA-BH-A0GY TCGA-BH-A1ET TCGA-OL-A5DA TCGA-AR-A2LE
31 TCGA-B6-A0X TCGA-AC-A2FB TCGA-AC-A2FK TCGA-A8-A0A TCGA-BH-A1FE TCGA-AC-A3TN TCGA-EW-A1PF TCGA-E2-A10A TCGA-OL-A5D TCGA-B6-A0RP TCGA-E2-A1B TCGA-A2-A1G TCGA-AR-A2LN TCGA-EW-A3E TCGA-A8-A06T TCGA-AR-A24X TCGA-A7-A5ZX TCGA-AN-A03X TCGA-A2-A0SY TCGA-A8-A06Y TCGA-C8-A12N TCGA-BH-A0B TCGA-C8-A12X TCGA-A8-A09T TCGA-AR-A0TZ TCGA-AR-A1AS TCGA-AC-A3HN TCGA-A8-A08C TCGA-A2-A0CP TCGA-A2-A0T TCGA-E9-A1R TCGA-AO-A1KT TCGA-BH-A0E TCGA-E9-A54X TCGA-GM-A3NY TCGA-A1-A0SG TCGA-AC-A5EH TCGA-AR-A TCGA-A8-A TCGA-GM-A3NW
32 TCGA-OL-A5D TCGA-AR-A5QP TCGA-AO-A0JA TCGA-B6-A40C TCGA-E9-A1N TCGA-BH-A0H TCGA-E2-A15O TCGA-AN-A0XN TCGA-D8-A1X TCGA-AO-A03R TCGA-E9-A3HO TCGA-BH-A1EO TCGA-E2-A10F TCGA-A8-A08H TCGA-AQ-A04J TCGA-BH-A0HA TCGA-JL-A3YX TCGA-GM-A2DL TCGA-LL-A TCGA-E2-A3DX TCGA-E2-A15C TCGA-A2-A04Q TCGA-BH-A1F TCGA-BH-A18M TCGA-AC-A3EH TCGA-C8-A12K TCGA-AC-A2FO TCGA-A2-A0EX TCGA-A2-A1FV TCGA-BH-A0AU TCGA-E2-A1IN TCGA-AR-A5QN TCGA-E9-A1ND TCGA-E9-A1N TCGA-A8-A0A TCGA-B6-A0RM TCGA-AR-A0U TCGA-BH-A0HB TCGA-B6-A0RN TCGA-E2-A1BD
33 TCGA-B6-A0IM TCGA-AR-A1AX TCGA-A2-A04V TCGA-E2-A15D TCGA-BH-A0H TCGA-C8-A26V TCGA-AO-A0J TCGA-B6-A0IJ TCGA-BH-A1FD TCGA-A8-A07E TCGA-A8-A09I TCGA-EW-A1P TCGA-A8-A0A TCGA-A2-A0YF TCGA-C8-A TCGA-BH-A0W TCGA-GM-A2DF TCGA-E2-A14S TCGA-D8-A1JP TCGA-A7-A26I TCGA-C8-A1HJ TCGA-E2-A15L TCGA-AN-A0XS TCGA-A8-A08T TCGA-E2-A1B TCGA-AN-A0AL TCGA-A8-A06X TCGA-E9-A TCGA-A2-A0EN TCGA-PE-A5DC TCGA-D8-A TCGA-AR-A0TP TCGA-AN-A0AK TCGA-A8-A06P TCGA-D8-A1Y TCGA-A8-A09C TCGA-E2-A1LB TCGA-A2-A0T TCGA-LQ-A4E TCGA-AR-A1AH
34 TCGA-BH-A0BT TCGA-A8-A08X TCGA-BH-A42T TCGA-A2-A0CO TCGA-BH-A18J TCGA-AO-A12F TCGA-B6-A0WW TCGA-AO-A0JE TCGA-B6-A0WX TCGA-BH-A0BV TCGA-GM-A2DH TCGA-AR-A1AP TCGA-B6-A0RL TCGA-A1-A0SD TCGA-D8-A1Y TCGA-B6-A0RH TCGA-AO-A1KP TCGA-A2-A0CK TCGA-AN-A0XR TCGA-BH-A0DK TCGA-A7-A0DA TCGA-A7-A4SF TCGA-AR-A1AQ TCGA-E9-A1RB TCGA-A7-A TCGA-D8-A1JJ TCGA-AR-A0U TCGA-A2-A0SV TCGA-EW-A TCGA-A2-A0YH TCGA-D8-A1JE TCGA-A2-A3XX TCGA-D8-A1JD TCGA-A2-A04N TCGA-D8-A1XB TCGA-AR-A0U TCGA-C8-A1HI TCGA-E9-A TCGA-A7-A0CE TCGA-AN-A0XO
35 TCGA-BH-A0HU TCGA-E2-A TCGA-BH-A TCGA-D8-A1JG TCGA-B6-A1KI TCGA-LL-A TCGA-B6-A0IQ TCGA-B6-A3ZX TCGA-A2-A0CW TCGA-E2-A1B TCGA-EW-A1OW TCGA-AR-A0TS TCGA-BH-A0AV TCGA-E9-A22E TCGA-A2-A3XU TCGA-GM-A2DO TCGA-C8-A27A TCGA-EW-A1PG TCGA-A2-A1FX TCGA-D8-A1JC TCGA-AR-A1AI TCGA-D8-A1JK TCGA-E9-A1R TCGA-BH-A0BL TCGA-A8-A08P TCGA-E2-A14Y TCGA-BH-A TCGA-C8-A TCGA-AC-A3QQ TCGA-E2-A10C TCGA-D8-A1JF TCGA-A2-A0D TCGA-MS-A51U TCGA-D8-A1XQ TCGA-A2-A0CL TCGA-AR-A1AW TCGA-E2-A1LK TCGA-E9-A1NA TCGA-BH-A1FJ TCGA-AC-A23G
36 TCGA-AC-A2QJ TCGA-BH-A1FN TCGA-A8-A08S TCGA-AR-A1AV TCGA-A2-A0CM TCGA-AO-A1KS TCGA-BH-A0WA TCGA-AO-A TCGA-E2-A15A TCGA-B6-A0WY TCGA-BH-A0H TCGA-C8-A1HO TCGA-B6-A TCGA-E2-A1IH TCGA-D8-A27M TCGA-A7-A4SA TCGA-A8-A09X TCGA-A2-A0D TCGA-A8-A09B TCGA-OL-A66K TCGA-BH-A1FM TCGA-AO-A0J TCGA-E2-A1AZ TCGA-BH-A18H TCGA-BH-A1F TCGA-A2-A0CU TCGA-BH-A0BZ TCGA-C8-A12O TCGA-C8-A12Q TCGA-A1-A0SP TCGA-AO-A0JJ TCGA-E2-A TCGA-E9-A1RH TCGA-D8-A1JB TCGA-GM-A3XL TCGA-BH-A0E TCGA-EW-A1J TCGA-C8-A26Y TCGA-A8-A0AB TCGA-B6-A
37 TCGA-AR-A TCGA-BH-A TCGA-B6-A0RS TCGA-C8-A1HG TCGA-BH-A0DI TCGA-E9-A TCGA-A8-A06Q TCGA-AN-A TCGA-A2-A0EU TCGA-E2-A TCGA-A8-A09K TCGA-E2-A1IJ TCGA-E2-A TCGA-AO-A0J TCGA-A8-A08O TCGA-AN-A0FY TCGA-GM-A2DK TCGA-E9-A1QZ TCGA-A8-A07B TCGA-EW-A1J TCGA-C8-A1HM TCGA-E9-A TCGA-C8-A12V TCGA-BH-A0HQ TCGA-A8-A07G TCGA-EW-A3U TCGA-AC-A5XU TCGA-BH-A1ES TCGA-A8-A TCGA-A2-A0CX TCGA-AR-A24K TCGA-A2-A0YT TCGA-EW-A1PH TCGA-BH-A1EX TCGA-BH-A0AY TCGA-A7-A4SB TCGA-E9-A TCGA-EW-A1P TCGA-E9-A1NE TCGA-D8-A
38 TCGA-EW-A TCGA-AQ-A1H TCGA-C8-A27B TCGA-B6-A0I TCGA-AO-A03P TCGA-C8-A12W TCGA-LL-A5YN TCGA-AN-A0XL TCGA-EW-A1P TCGA-BH-A18T TCGA-AN-A0FV TCGA-D8-A1Y TCGA-AR-A2LK TCGA-D8-A1XF TCGA-E9-A3QA TCGA-AO-A12E TCGA-AR-A0U TCGA-AR-A24Z TCGA-BH-A0AZ TCGA-D8-A1XM TCGA-B6-A0IO TCGA-BH-A0DE TCGA-E2-A14O TCGA-E9-A5FL TCGA-C8-A1HK TCGA-AN-A0AJ TCGA-D8-A1J TCGA-A8-A08R TCGA-AO-A12B TCGA-E9-A1R TCGA-E9-A TCGA-A2-A0ET TCGA-A1-A0SH TCGA-BH-A0BF TCGA-BH-A0DD TCGA-A2-A0EQ TCGA-AR-A TCGA-BH-A0C TCGA-EW-A1J TCGA-A8-A07O
39 TCGA-AR-A0TX TCGA-A8-A06Z TCGA-GI-A2C TCGA-C8-A26Z TCGA-AO-A0JG TCGA-E2-A56Z TCGA-A2-A1G TCGA-BH-A1EW TCGA-BH-A18N TCGA-OL-A5D TCGA-A8-A TCGA-A2-A0SU TCGA-BH-A0BP TCGA-B6-A0IN TCGA-D8-A1XT TCGA-E9-A1R TCGA-A2-A25D TCGA-AR-A24V TCGA-E9-A1R TCGA-D8-A TCGA-A2-A04Y TCGA-AR-A24P TCGA-A7-A26J TCGA-E9-A1R TCGA-A1-A0SJ TCGA-E2-A1L TCGA-C8-A3M TCGA-AO-A03T TCGA-E9-A1RE TCGA-BH-A0C TCGA-A8-A06O TCGA-AC-A2QH TCGA-D8-A27F TCGA-C8-A12L TCGA-AN-A0FZ TCGA-BH-A0BW TCGA-A2-A3XV TCGA-AR-A24H TCGA-B6-A2IU TCGA-A2-A0YC
40 TCGA-B6-A0RE TCGA-A7-A26G TCGA-GM-A2DC TCGA-AR-A0TQ TCGA-C8-A1HF TCGA-A2-A25E TCGA-A8-A07P TCGA-D8-A27W TCGA-B6-A1KN TCGA-D8-A1X TCGA-E2-A1IE TCGA-BH-A1FC TCGA-D8-A27H TCGA-AO-A0J TCGA-AC-A62X TCGA-A2-A3XT TCGA-B6-A TCGA-BH-A5IZ TCGA-B6-A0WV TCGA-BH-A0BG TCGA-AO-A03L TCGA-A2-A25B TCGA-AR-A TCGA-AN-A TCGA-B6-A0X TCGA-A2-A0SW TCGA-AN-A0FL TCGA-A7-A3J TCGA-AO-A03O TCGA-BH-A18S TCGA-A8-A07L TCGA-E2-A14R TCGA-B6-A1KC TCGA-D8-A1JL TCGA-E9-A1RI TCGA-A8-A TCGA-C8-A1HN TCGA-BH-A1F TCGA-A2-A0YM TCGA-AR-A24Q
41 TCGA-AQ-A54O TCGA-A8-A07R TCGA-A8-A06U TCGA-A1-A0SO TCGA-A7-A13F TCGA-BH-A0B TCGA-D8-A1XY TCGA-AN-A0XT TCGA-AR-A1AK TCGA-E9-A22B TCGA-AN-A04D TCGA-A2-A0CT TCGA-LL-A5YM TCGA-BH-A0HX TCGA-E2-A15T TCGA-D8-A1JT TCGA-AR-A24L TCGA-B6-A0RI TCGA-B6-A0I TCGA-A8-A TCGA-E2-A15S TCGA-A8-A07W TCGA-BH-A TCGA-E9-A5UO TCGA-AN-A0AM TCGA-BH-A1FG TCGA-D8-A1XL TCGA-A2-A1FW TCGA-HN-A2NL TCGA-AC-A2FM TCGA-A2-A0EV TCGA-E9-A1NI TCGA-AN-A0XU TCGA-AO-A0J TCGA-A8-A09D TCGA-A2-A04T TCGA-B6-A0RG TCGA-A8-A TCGA-BH-A18Q TCGA-C8-A12U
42 TCGA-AO-A1KR TCGA-A8-A06R TCGA-A7-A0CJ TCGA-D8-A1XS TCGA-AC-A2BK TCGA-AN-A04C TCGA-BH-A0DG TCGA-A8-A09A TCGA-D8-A1XK TCGA-A8-A06N TCGA-A8-A09R TCGA-D8-A TCGA-EW-A1PC TCGA-EW-A1P TCGA-A7-A13D TCGA-A1-A0SM TCGA-A2-A4S TCGA-A8-A09M TCGA-BH-A18L TCGA-C8-A TCGA-D8-A1X TCGA-BH-A0HY TCGA-A2-A04P TCGA-EW-A1OY TCGA-LL-A5YP TCGA-E2-A TCGA-D8-A1X TCGA-EW-A1PD TCGA-A2-A0T TCGA-AR-A2LL TCGA-C8-A TCGA-E2-A1IG TCGA-BH-A0AW TCGA-BH-A0C TCGA-A8-A TCGA-A7-A0CD TCGA-BH-A0HW TCGA-A2-A04R TCGA-A8-A08F TCGA-E2-A1LA
43 TCGA-BH-A18G TCGA-E9-A2JS TCGA-BH-A0B TCGA-A7-A5ZV TCGA-AO-A1KQ TCGA-A8-A09W TCGA-A8-A TCGA-EW-A1OZ TCGA-A7-A2KD TCGA-A2-A0T TCGA-C8-A TCGA-E2-A TCGA-A2-A0YE TCGA-E2-A14W TCGA-C8-A12M TCGA-E9-A5UP TCGA-A2-A0T TCGA-A8-A08J TCGA-EW-A1OX Parameter Pearson r CSNK1D (CNV) vs. CSNK1D (RNASeq) r % confidence interval to R squared P value P (two-tailed) < P value summary **** Significant? (alpha = 0.05) Yes Number of XY Pairs 972 Table S2. TCGA RNA-seq and GISTIC2 copy number data for basal-like Pam50 breast tumors. Case ID CSNK1D (log2 CNV) CSNK1D (log2 RNASeq) TCGA-B6-A1KF TCGA-D8-A1JM TCGA-AN-A0FJ TCGA-BH-A18V
44 TCGA-AR-A1AR TCGA-BH-A0E TCGA-AR-A1AY TCGA-E2-A TCGA-BH-A1F TCGA-B6-A0RU TCGA-E9-A22G TCGA-E2-A1LL TCGA-E2-A14X TCGA-A2-A0D TCGA-AO-A0JL TCGA-A1-A0SK TCGA-A2-A1G TCGA-A7-A26F TCGA-E2-A1II TCGA-C8-A TCGA-E2-A TCGA-A2-A04U TCGA-AR-A1AJ TCGA-A2-A0SX TCGA-BH-A0E TCGA-BH-A0RX TCGA-AR-A2LR TCGA-E2-A1LI TCGA-AO-A TCGA-B6-A0I TCGA-E2-A1LG TCGA-A2-A0T TCGA-A8-A07U TCGA-BH-A0DL TCGA-E2-A14N TCGA-A2-A25F TCGA-AN-A0FX TCGA-AO-A TCGA-AN-A0AT TCGA-EW-A1PB TCGA-B6-A0RT TCGA-EW-A1P TCGA-A7-A13E TCGA-AR-A TCGA-A2-A0ST TCGA-A2-A0YJ
45 TCGA-E2-A1LH TCGA-E9-A1N TCGA-AQ-A04J TCGA-A2-A04Q TCGA-C8-A12K TCGA-E9-A1ND TCGA-E9-A1N TCGA-AR-A0U TCGA-B6-A0IJ TCGA-C8-A TCGA-GM-A2DF TCGA-A7-A26I TCGA-C8-A1HJ TCGA-AN-A0AL TCGA-AR-A0TP TCGA-AR-A1AH TCGA-AO-A12F TCGA-B6-A0WX TCGA-A7-A0DA TCGA-AR-A1AQ TCGA-AR-A0U TCGA-A7-A0CE TCGA-E2-A TCGA-B6-A0IQ TCGA-EW-A1OW TCGA-AR-A0TS TCGA-BH-A0AV TCGA-AR-A1AI TCGA-D8-A1JK TCGA-BH-A0BL TCGA-E2-A14Y TCGA-D8-A1XQ TCGA-E2-A1LK TCGA-A2-A0CM TCGA-BH-A0WA TCGA-AO-A TCGA-D8-A27M TCGA-A2-A0D TCGA-AO-A0J TCGA-E2-A1AZ TCGA-BH-A1F TCGA-A1-A0SP
46 TCGA-E9-A TCGA-C8-A12V TCGA-EW-A1PH TCGA-D8-A TCGA-C8-A27B TCGA-BH-A18T TCGA-AR-A0U TCGA-A8-A08R TCGA-E9-A TCGA-A8-A07O TCGA-GI-A2C TCGA-D8-A TCGA-AC-A2QH TCGA-D8-A27F TCGA-BH-A0BW TCGA-B6-A0RE TCGA-A7-A26G TCGA-BH-A1FC TCGA-D8-A27H TCGA-AO-A0J TCGA-BH-A0BG TCGA-AR-A TCGA-B6-A0X TCGA-AN-A0FL TCGA-E2-A14R TCGA-D8-A1JL TCGA-A2-A0YM TCGA-AR-A24Q TCGA-A8-A07R TCGA-A1-A0SO TCGA-BH-A0B TCGA-AN-A04D TCGA-B6-A0I TCGA-HN-A2NL TCGA-AN-A0XU TCGA-A2-A04T TCGA-BH-A18Q TCGA-AO-A1KR TCGA-AC-A2BK TCGA-D8-A1XK TCGA-D8-A TCGA-EW-A1P
47 TCGA-A7-A13D TCGA-A2-A04P TCGA-A2-A0T TCGA-BH-A18G TCGA-A2-A0YE Parameter CSNK1D (CNV) vs. CSNK1D (RNASeq) Number of XY Pairs 135 Pearson r % confidence interval to P value (two-tailed) < P value summary **** Is the correlation significant? (alpha=0.05) Yes R square Table S3. TCGA RNA-seq and GISTIC2 copy number data for HER2-positive Pam50 breast tumors. Case ID CSNK1D (log2 CNV) CSNK1D (log2 RNASeq) TCGA-D8-A1JA TCGA-A8-A07I TCGA-D8-A1XJ TCGA-C8-A12Z TCGA-B6-A0IK TCGA-A8-A08B TCGA-BH-A0EE TCGA-BH-A18R TCGA-BH-A1EV TCGA-E2-A TCGA-A8-A TCGA-BH-A1EN TCGA-EW-A1OV TCGA-E2-A14V TCGA-C8-A TCGA-A2-A0D TCGA-BH-A18P TCGA-C8-A12P TCGA-C8-A26X TCGA-AO-A12D TCGA-AC-A23H
48 TCGA-D8-A13Z TCGA-A2-A04W TCGA-AR-A24U TCGA-A8-A08L TCGA-EW-A2FR TCGA-A2-A04X TCGA-E2-A14P TCGA-A8-A0A TCGA-A8-A09G TCGA-C8-A TCGA-C8-A12T TCGA-BH-A0B TCGA-GM-A2DB TCGA-AR-A TCGA-E9-A TCGA-E2-A1LB TCGA-A8-A08X TCGA-AO-A0JE TCGA-GM-A2DH TCGA-B6-A0RH TCGA-D8-A1JG TCGA-E2-A1B TCGA-D8-A1JF TCGA-A8-A09X TCGA-C8-A12Q TCGA-E9-A1RH TCGA-C8-A26Y TCGA-B6-A0RS TCGA-A2-A0CX TCGA-B6-A0I TCGA-AN-A0FV TCGA-C8-A1HK TCGA-A2-A0EQ TCGA-AR-A0TX TCGA-D8-A1XT TCGA-C8-A12L TCGA-C8-A1HF TCGA-BH-A TCGA-AO-A0J TCGA-AN-A04C TCGA-C8-A TCGA-C8-A
49 TCGA-BH-A0AW TCGA-C8-A TCGA-A2-A0T TCGA-A8-A08J Parameter CSNK1D (CNV) vs. CSNK1D (RNASeq) Number of XY Pairs 67 Pearson r % confidence interval to P value (two-tailed) < P value summary **** Is the correlation significant? (alpha=0.05) Yes R square Table S4. TCGA RNA-seq and GISTIC2 copy number data for luminal A Pam50 breast tumors. Case ID CSNK1D (log2 CNV) CSNK1D (log2 RNASeq) TCGA-E2-A TCGA-D8-A1JN TCGA-EW-A1J TCGA-A7-A0D TCGA-B6-A0IG TCGA-E9-A1RF TCGA-GM-A2D TCGA-BH-A0DZ TCGA-AO-A0J TCGA-D8-A27T TCGA-D8-A27V TCGA-B6-A0IE TCGA-E2-A15H TCGA-AN-A0FW TCGA-D8-A1XU TCGA-BH-A0BC TCGA-BH-A0B TCGA-BH-A1EY TCGA-EW-A1PA TCGA-GM-A2DA TCGA-AO-A03V TCGA-BH-A18F
50 TCGA-AN-A0FD TCGA-AN-A04A TCGA-BH-A0HP TCGA-B6-A0RV TCGA-AR-A1AN TCGA-AR-A0U TCGA-E2-A14T TCGA-AN-A0AS TCGA-BH-A0BR TCGA-A7-A0CG TCGA-AQ-A0Y TCGA-BH-A0C TCGA-A2-A0CV TCGA-A8-A0AD TCGA-BH-A0DP TCGA-C8-A3M TCGA-C8-A TCGA-GI-A2C TCGA-A2-A TCGA-E9-A1NH TCGA-BH-A0BA TCGA-E2-A1B TCGA-B6-A0IH TCGA-BH-A1EU TCGA-AN-A TCGA-BH-A0B TCGA-E2-A14Z TCGA-D8-A TCGA-BH-A18I TCGA-A7-A26E TCGA-A7-A26H TCGA-BH-A1FH TCGA-GM-A2DI TCGA-AN-A0FT TCGA-E2-A15G TCGA-D8-A TCGA-BH-A0E TCGA-E2-A15M TCGA-E2-A1B TCGA-E2-A15E TCGA-C8-A TCGA-AN-A0XW
51 TCGA-AQ-A1H TCGA-A1-A0SQ TCGA-BH-A28Q TCGA-AC-A23E TCGA-GM-A2DN TCGA-A7-A3IZ TCGA-E9-A2JT TCGA-A2-A0ER TCGA-E9-A1N TCGA-E2-A10B TCGA-D8-A27E TCGA-BH-A0EA TCGA-D8-A1XG TCGA-EW-A2FS TCGA-E2-A14Q TCGA-AO-A0JI TCGA-A2-A0CS TCGA-BH-A0DX TCGA-D8-A1XO TCGA-A7-A0CH TCGA-A2-A0ES TCGA-BH-A0BJ TCGA-AO-A12A TCGA-A2-A0CQ TCGA-E2-A1IL TCGA-B6-A0IA TCGA-E2-A1L TCGA-BH-A0EI TCGA-AN-A0FS TCGA-AN-A0XP TCGA-BH-A TCGA-E2-A15P TCGA-D8-A1JS TCGA-BH-A0HI TCGA-BH-A0DO TCGA-A2-A0EM TCGA-E9-A3Q TCGA-E2-A1BC TCGA-B6-A0WT TCGA-D8-A27G TCGA-A1-A0SF TCGA-D8-A1XC
52 TCGA-A2-A3KD TCGA-AO-A12G TCGA-BH-A0DQ TCGA-BH-A0H TCGA-C8-A1HE TCGA-E9-A1N TCGA-A7-A3J TCGA-A8-A09V TCGA-AR-A24M TCGA-E9-A1R TCGA-A2-A0YI TCGA-A8-A0A TCGA-AR-A24W TCGA-A1-A0SE TCGA-E2-A15I TCGA-A7-A3IY TCGA-A2-A3KC TCGA-BH-A0BM TCGA-AR-A1AL TCGA-AC-A23C TCGA-BH-A0BQ TCGA-E9-A1RD TCGA-A8-A0A TCGA-B6-A0RO TCGA-A7-A13G TCGA-D8-A1JU TCGA-GM-A2DM TCGA-BH-A18K TCGA-D8-A1XD TCGA-AR-A0TR TCGA-B6-A0IC TCGA-D8-A27L TCGA-AR-A24T TCGA-AC-A2FG TCGA-A2-A0D TCGA-C8-A TCGA-B6-A0I TCGA-B6-A0X TCGA-B6-A0X TCGA-E9-A TCGA-AO-A0J TCGA-D8-A1XA
53 TCGA-D8-A27K TCGA-B6-A0IP TCGA-EW-A1J TCGA-BH-A0DV TCGA-BH-A0H TCGA-C8-A12Y TCGA-E2-A1IK TCGA-AO-A0JF TCGA-AO-A12H TCGA-A2-A0YD TCGA-BH-A0DS TCGA-AN-A0XV TCGA-BH-A0BO TCGA-AQ-A04L TCGA-BH-A0GZ TCGA-BH-A1FL TCGA-BH-A1FR TCGA-E9-A1RC TCGA-A8-A TCGA-AR-A0TW TCGA-A2-A0T TCGA-B6-A0WS TCGA-EW-A1IX TCGA-D8-A1JH TCGA-EW-A1PE TCGA-AR-A24O TCGA-AN-A0FK TCGA-D8-A1XV TCGA-BH-A0H TCGA-B6-A0WZ TCGA-D8-A27P TCGA-A8-A TCGA-AC-A3OD TCGA-BH-A1FB TCGA-A2-A1FZ TCGA-E2-A15R TCGA-E2-A1IO TCGA-AO-A TCGA-BH-A0HK TCGA-EW-A2FV TCGA-AO-A TCGA-E9-A1NG
54 TCGA-A2-A0EW TCGA-E2-A1L TCGA-D8-A27I TCGA-E2-A1L TCGA-AN-A0FN TCGA-BH-A0E TCGA-AC-A2B TCGA-AR-A1AU TCGA-AR-A2LO TCGA-D8-A TCGA-BH-A0HO TCGA-E2-A15J TCGA-A8-A08Z TCGA-AC-A2FF TCGA-BH-A0BS TCGA-AR-A2LM TCGA-BH-A0EB TCGA-E9-A TCGA-A7-A0DB TCGA-D8-A1X TCGA-A2-A0T TCGA-EW-A1IW TCGA-BH-A0W TCGA-A2-A0EO TCGA-E9-A TCGA-E9-A1N TCGA-BH-A0DT TCGA-A8-A07J TCGA-BH-A0DH TCGA-A2-A0YL TCGA-AO-A03M TCGA-E2-A1IF TCGA-AO-A0JC TCGA-E2-A1IU TCGA-BH-A2L TCGA-BH-A0W TCGA-E9-A24A TCGA-E2-A10E TCGA-A8-A07F TCGA-E2-A TCGA-BH-A0GY TCGA-BH-A1ET
For bi-directional devices, use suffix C or CA (e.g. SMAJ10C, SMAJ10CA). Electrical characteristics apply in both directions.
Transient Suppressor Features Optimized for LAN protection applications Low profile package with built-in strain relief for surface mounted applications Low incremental surge resistance, excellent clamping
Production specification. Low profile package with built-in strain relief for surface mounted applications
FEATURES Plastic package has underwriters laboratory flammability classification 94V-0 Optimized for LAN protection applications Low profile package with built-in strain relief for surface mounted applications
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