CHAPTER 5 THE GENETIC ARCHITECTURE OF LIVER ENZYME LEVELS: GGT, ALT AND AST 3. Abstract

HTML
DOWNLOAD

Μέγεθος: px

Εμφάνιση ξεκινά από τη σελίδα:

Download "CHAPTER 5 THE GENETIC ARCHITECTURE OF LIVER ENZYME LEVELS: GGT, ALT AND AST 3. Abstract"

Ἀλκαῖος Λαιμός
8 χρόνια πριν
Προβολές:

1 THEGENETICARCHITECTUREOFLIVERENZYMELEVELS:GGT,ALTANDAST CHAPTER5 THEGENETICARCHITECTUREOFLIVERENZYMELEVELS:GGT,ALTANDAST 3 Abstract 3 99

2 CHAPTER5 1.Introduction 100

3 THEGENETICARCHITECTUREOFLIVERENZYMELEVELS:GGT,ALTANDAST GGT1 GGT1GGT2GGTLA4 GGT1PIWIL3 CELF2 101

4 CHAPTER5 2.Methods 2.1Participants 2.2Assessmentofliverenzymes 102

5 THEGENETICARCHITECTUREOFLIVERENZYMELEVELS:GGT,ALTANDAST Table1 Zygositybysexgroup a twins b siblings parents spouses 2.3Statisticalanalyses ln zz z 103

6 CHAPTER5 104

7 THEGENETICARCHITECTUREOFLIVERENZYMELEVELS:GGT,ALTANDAST Figure1 105

8 CHAPTER5 3.Results p p p p p p p p p p p p p p p p 106

9 Table2 Males Females mean a median a correlationswith mean a median a correlationswith (SD) (range) ALT AST age (SD) (range) ALT AST age ln

10 CHAPTER5 Figure2a Figure2b Figure2c 108

11 THEGENETICARCHITECTUREOFLIVERENZYMELEVELS:GGT,ALTANDAST GGT r r r pr r r p p p p p p p p 109

12 Table3 additive proportionofphenotypicvariance spouse genetic explainedby SD a corr variance A D C E % 28.5% 41.9% 19.8%40.2% 19.2%37.5% 35.6%49.1% % 27.6% 40.2% 23.4%41.4% 17.8%37.5% 35.3%45.7% % 59.6% 31.9%51.8% 51.8%68.0% % 77.6% 16.6%28.5% 71.6%83.7% % 14.7% 57.3% 22.6%33.5% 7.1%22.3% 51.8%63.5% % 14.7% 57.3% 22.6%33.5% 7.1%22.3% 51.8%63.5% ln

13 THEGENETICARCHITECTUREOFLIVERENZYMELEVELS:GGT,ALTANDAST ALT r r r r r p p p p p AST r pr p p p p 111

14 CHAPTER5 4.Discussion GSTT2B,GGT1 112

15 THEGENETICARCHITECTUREOFLIVERENZYMELEVELS:GGT,ALTANDAST ATP8B1ALDH2 HNF1A,CEPT1 GCKR,MLXIPL,SLC2A2 GCKR,STAT4,CDH6,ITGA1,HNF1A,RORA,CD276 FUT2 C14orf73 PNPLA3 MRC1 TRIB1,CHUK CPN1 SAMM50 113

16 CHAPTER5 r r r 114

17 THEGENETICARCHITECTUREOFLIVERENZYMELEVELS:GGT,ALTANDAST 115

18 116

19 THEGENETICARCHITECTUREOFLIVERENZYMELEVELS:GGT,ALTANDAST SUPPLEMENTTOCHAPTER5 THEGENETICARCHITECTUREOFLIVERENZYMELEVELS:GGT,ALTANDAST Statisticalanalysisofthegeneticarchitectureofliverenzymelevels 117

20 CHAPTER5 tttt 118

21 THEGENETICARCHITECTUREOFLIVERENZYMELEVELS:GGT,ALTANDAST r 119

22 CHAPTER5 and 120

23 TableS1 Model NP 2LL df vs 2 df p Effectoncorrelations GGT ALT

24 AST df dfdf

25 TableS2a Modelcomparison Test Phenotype df Constraints 1bvs1a df df df df df df Numberofparameterssaturatedmodelwithconstraints:25 df df df df df Numberofparameterssaturatedmodelwithconstraints:23 df df df df df Numberofparameterssaturatedmodelwithconstraints:22

26 TableS2b Model comparison Test Pheno type 2avs1b 2bvs2a 2cvs1b 3avs1b 3bvs1b 3dvs3c 3evs1b df Constraints df df df df df df df df df df df df df df df 4vs1b df df

27 TableS2c Model comparison ACEwithshared environmental transmissionvs 1b Test Phenotype df Constraints Numberofparameterssaturatedmodelwithconstraints(model1b):25 NumberofparametersACEmodelwithCT:17 r Numberofparameterssaturatedmodelwithconstraints:23 NumberofparametersACEmodelwithCT:17 r Numberofparameterssaturatedmodelwithconstraints:22 NumberofparametersACEmodelwithCT:13

28 ACDEvs1b r Numberofparameterssaturatedmodelwithconstraints:25 NumberofparametersACDEmodel:17 Numberofparameterssaturatedmodelwithconstraints:23 NumberofparametersACEmodelwithCT:17 Numberofparameterssaturatedmodelwithconstraints:22 NumberofparametersACEmodelwithCT:12

29 ADEvsACDE ACEvsACDE AEvsACDE df df df df df df

30 128

Σχετικά έγγραφα

Longitudinal Changes in Component Processes of Working Memory

This Accepted Manuscript has not been copyedited and formatted. The final version may differ from this version. Research Article: New Research Cognition and Behavior Longitudinal Changes in Component Processes