Calcitonin Gene-Related Peptide and Migraine:

Μέγεθος: px

Εμφάνιση ξεκινά από τη σελίδα:

Download "Calcitonin Gene-Related Peptide and Migraine:"

Ζώσιμος Παπαϊωάννου
6 χρόνια πριν
Προβολές:

1 Calcitonin Gene-Related Peptide and Migraine: Implications for Therapy Udayasankar Arulmani

2 Calcitonin Gene-Related Peptide and Migraine: Implications for Therapy Thesis, Erasmus University, Rotterdam. With summary in Dutch ISBN U. Arulmani 2004 All rights reserved. Save exceptions stated by the law, no part of this publication may be reproduced, stored in a retrieval system of any nature, or transmitted in any form or means, electronic, mechanical, photocopying, recording or otherwise, included a complete or partial transcription, without the prior written permission of the author, application of which should be addressed to Udayasankar Arulmani, Department of Pharmacology, Erasmus Medical Centre, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands. An electronic version of this thesis is available in Adobe PDF-format on the following internet address: Printed by: Optima, Rotterdam

3 Calcitonin Gene-Related Peptide and Migraine: Implications for Therapy Calcitonine gen-gerelateerde peptide en migraine: Implicaties voor therapie Proefschrift ter verkrijging van de graad van doctor aan de Erasmus Universiteit Rotterdam op gezag van de Rector Magnificus Prof.dr. S.W.J. Lamberts en volgens besluit van het College voor Promoties De openbare verdediging zal plaatsvinden op vrijdag 11 juni 2004 om uur door Udayasankar Arulmani geboren te Chennai (Madras), India

4 Promotiecommissie Promotor: Prof.dr. P.R. Saxena Overige leden: Prof.dr. C.M. Villalón Prof.dr. D.J. Duncker Prof.dr. C.I. de Zeeuw Financial support of the following institutions and companies is gratefully acknowledged: AngloDutch Migraine Association (ADMA, Amsterdam, The Netherlands), Boehringer Ingelheim Pharma KG, Erasmus Universiteit Rotterdam (Rotterdam, The Netherlands), GlaxoSmithkline B.V., Harlan Nederland, J. E. Jurriaanse Stichting, Janssen-Cilag B.V, Merck Sharp & Dohme B.V., Nederlandse Hoofdpijn Vereniging (Breda, The Netherlands).

5 TABLE OF CONTENTS 1 INTRODUCTION HISTORICAL PERSPECTIVE EPIDEMIOLOGY CO-MORBIDITY DIAGNOSTIC CRITERIA PATHOPHYSIOLOGY OF MIGRAINE EXPERIMENTAL MODELS FOR ACUTELY-ACTING ANTIMIGRAINE DRUGS MANAGEMENT OF MIGRAINE CALCITONIN GENE-RELATED PEPTIDE CGRP RECEPTORS CGRP PEPTIDE ASSAY PHYSIOLOGICAL FUNCTIONS OF CGRP THERAPEUTIC POTENTIALS OF CGRP RECEPTOR LIGANDS CGRP AND MIGRAINE; POTENTIAL TARGETS FOR MIGRAINE THERAPY AIMS OF THIS THESIS EFFECTS OF THE CGRP RECEPTOR ANTAGONIST BIBN4096BS ON CAPSAICIN-INDUCED CAROTID HAEMODYNAMIC CHANGES IN ANAESTHETISED PIGS INTRODUCTION MATERIALS AND METHODS RESULTS DISCUSSION EFFECTS OF BIBN4096BS ON CARDIAC OUTPUT DISTRIBUTION AND ON CGRP-INDUCED CAROTID HAEMODYNAMIC RESPONSES IN THE PIG INTRODUCTION MATERIALS AND METHODS RESULTS DISCUSSION EFFECTS OF SUMATRIPTAN ON CAPSAICIN-INDUCED CAROTID HAEMODYNAMIC CHANGES AND CGRP RELEASE IN ANAESTHETISED PIGS INTRODUCTION MATERIALS AND METHODS RESULTS DISCUSSION EFFECTS OF THE CGRP RECEPTOR ANTAGONIST BIBN4096BS ON α-cgrp-induced REGIONAL HAEMODYNAMIC CHANGES IN ANAESTHETISED RATS INTRODUCTION MATERIALS AND METHODS RESULTS DISCUSSION...124

6 6 DISCUSSION GENERAL CAPSAICIN-INDUCED CAROTID HAEMODYNAMIC RESPONSES AND CGRP RELEASE EFFECTS OF BIBN4096BS ON CAPSAICIN-INDUCED CAROTID HAEMODYNAMIC RESPONSES EFFECTS OF SUMATRIPTAN ON CAPSAICIN-INDUCED CAROTID HAEMODYNAMIC RESPONSES EFFECTS OF BIBN4096BS ON α-cgrp-induced CAROTID HAEMODYNAMIC RESPONSES ROLE OF ENDOGENOUS CGRP IN REGULATING BASAL VASCULAR TONE PRE- AND POST-JUNCTIONAL CGRP MODULATION: IMPLICATIONS FOR MIGRAINE TREATMENT IMPLICATIONS FOR FUTURE ANTIMIGRAINE THERAPY CONCLUSION SUMMARY SUMMARY IN ENGLISH SAMENVATTING IN HET NEDERLANDS (SUMMARY IN DUTCH) APPENDIX ACKNOWLEDGEMENT ABOUT THE AUTHOR PUBLICATIONS LIST OF ABBREVIATIONS REFERENCES...160

Σχετικά έγγραφα

Κλινικοί Εκπαιδευτές: σύντομη περιγραφή ρόλου, κριτήρια επιλογής & πρόγραμμα εκπαίδευσης

Κλινικοί Εκπαιδευτές: σύντομη περιγραφή ρόλου, κριτήρια επιλογής & πρόγραμμα εκπαίδευσης σύντομη περιγραφή ρόλου, κριτήρια επιλογής & πρόγραμμα εκπαίδευσης 1 Σεπτέμβριος 2012 2012 4 η ΥΠΕ. Με επιφύλαξη παντός δικαιώματος. Απαγορεύεται αναδημοσίευση της έκδοσης σε οποιαδήποτε μορφή, ολόκληρης