** ** * ** ** ** ** ** **

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" 6DAFDOIECE?=IJH=EE@AN251M=I?=?K=JA@=??H@ECJH=AJ=&KIEC6JOF EIJA=@BHA?J=JAFAH=JKHA 251# 6JOF!'#`6JOF # 04&`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

# )BJAHJDAEEJE=IJAAFE?HA=IA6JOFJA@A@JF=JA=KMEJDE `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ympanic temperature ( o C) 38.0 37.8 37.6 37.4 37.2 37.0 36.8 before HDBR1 after HDBR1 before HDBR2 after HDBR2 * * * * * -10-5 0 5 10 15 20 25 30 35 40 45 Mean skin temparature ( o C) 33.8 33.4 33.0 32.6 32.2 31.8-10 -5 0 5 10 15 20 25 30 35 40 45 Time (min).ec6ea?khiab?d=caie JOF=E?=@A=IE JAFAH=JKHAI@KHECJDABKH ANAH?EIAJAIJI)IJAHEII@AJA IECEBE?=J@EBBAHA?AI>AJMAA L=KAI>J=EA@>ABHA=@=BJAH 0,*4F#F

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τ=@IMA=JECJDHAID@HA=JA@JJOF=E?JAFAH=JKHA 8=HE=>A *ABHA0,*4 )BJAH0,*4 *ABHA0,*4 )BJAH0,*4 5MA=JECIAJI & '!&!! &%!!#!# τ I $%!% ""!"! $ " 5MA=JECJDHAID@+!%&&!%!$!%&!%& 8=KAI=HAA=I5-)IJAHEI@AJAIIECEBE?=J@EBBAHA?AE?F=HEIMEJDJDAJAIJ>ABHA 0,*4F# 2.0 2.0 Local sweating rate (mg/cm 2 /min) 1.6 1.2 0.8 0.4 0.0 Time (min) before HDBR1 after HDBR1 before HDBR2 after HDBR2 0 5 10 15 20 25 30 35 40 45 (mg/cm 2 /min) 1.6 1.2 0.8 0.4 * 0.0 36.9 37.1 37.3 37.5 37.7 37.9 38.1 Tympanic temperature ( o C).EC 6EA?KHIAB?=?DAIJIMA=JH=JA@KHECANAH?EIAABJF=A=@HA=JEIDEF>AJMAA IMA=JH=JA=@JOF=E?JAFAH=JKHAHECDJF=ABHJDABKHJAIJI)IJAHEI@AJAIIECEBE?=J @EBBAHA?AEIMA=JECJDHAID@>AJMAAJDAFHA=@FIJ0,*4JAIJIF#

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