THEGENETICARCHITECTUREOFLIVERENZYMELEVELS:GGT,ALTANDAST CHAPTER5 THEGENETICARCHITECTUREOFLIVERENZYMELEVELS:GGT,ALTANDAST 3 Abstract 3 99
CHAPTER5 1.Introduction 100
THEGENETICARCHITECTUREOFLIVERENZYMELEVELS:GGT,ALTANDAST GGT1 GGT1GGT2GGTLA4 GGT1PIWIL3 CELF2 101
CHAPTER5 2.Methods 2.1Participants 2.2Assessmentofliverenzymes 102
THEGENETICARCHITECTUREOFLIVERENZYMELEVELS:GGT,ALTANDAST Table1 Zygositybysexgroup a twins b siblings parents spouses 2.3Statisticalanalyses ln zz z 103
CHAPTER5 104
THEGENETICARCHITECTUREOFLIVERENZYMELEVELS:GGT,ALTANDAST Figure1 105
CHAPTER5 3.Results p p p p p p p p p p p p p p p p 106
Table2 Males Females mean a median a correlationswith mean a median a correlationswith (SD) (range) ALT AST age (SD) (range) ALT AST age ln
CHAPTER5 Figure2a Figure2b Figure2c 108
THEGENETICARCHITECTUREOFLIVERENZYMELEVELS:GGT,ALTANDAST GGT r r r pr r r p p p p p p p p 109
Table3 additive proportionofphenotypicvariance spouse genetic explainedby SD a corr variance A D C E 5.46.00 1.00 29.6% 28.5% 41.9% 19.8%40.2% 19.2%37.5% 35.6%49.1% 5.46.00 1.00 32.2% 27.6% 40.2% 23.4%41.4% 17.8%37.5% 35.3%45.7% 4.54.15 1.42 40.4% 59.6% 31.9%51.8% 51.8%68.0% 4.54.15 1.42 22.4% 77.6% 16.6%28.5% 71.6%83.7% 2.86.15 1.47 28.0% 14.7% 57.3% 22.6%33.5% 7.1%22.3% 51.8%63.5% 2.62.15 1.47 28.0% 14.7% 57.3% 22.6%33.5% 7.1%22.3% 51.8%63.5% ln
THEGENETICARCHITECTUREOFLIVERENZYMELEVELS:GGT,ALTANDAST ALT r r r r r p p p p p AST r pr p p p p 111
CHAPTER5 4.Discussion GSTT2B,GGT1 112
THEGENETICARCHITECTUREOFLIVERENZYMELEVELS:GGT,ALTANDAST ATP8B1ALDH2 HNF1A,CEPT1 GCKR,MLXIPL,SLC2A2 GCKR,STAT4,CDH6,ITGA1,HNF1A,RORA,CD276 FUT2 C14orf73 PNPLA3 MRC1 TRIB1,CHUK CPN1 SAMM50 113
CHAPTER5 r r r 114
THEGENETICARCHITECTUREOFLIVERENZYMELEVELS:GGT,ALTANDAST 115
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THEGENETICARCHITECTUREOFLIVERENZYMELEVELS:GGT,ALTANDAST SUPPLEMENTTOCHAPTER5 THEGENETICARCHITECTUREOFLIVERENZYMELEVELS:GGT,ALTANDAST Statisticalanalysisofthegeneticarchitectureofliverenzymelevels 117
CHAPTER5 tttt 118
THEGENETICARCHITECTUREOFLIVERENZYMELEVELS:GGT,ALTANDAST r 119
CHAPTER5 and 120
TableS1 Model NP 2LL df vs 2 df p Effectoncorrelations GGT ALT
AST df dfdf
TableS2a Modelcomparison Test Phenotype df Constraints 1bvs1a df df df df df df Numberofparameterssaturatedmodelwithconstraints:25 df df df df df Numberofparameterssaturatedmodelwithconstraints:23 df df df df df Numberofparameterssaturatedmodelwithconstraints:22
TableS2b Model comparison Test Pheno type 2avs1b 2bvs2a 2cvs1b 3avs1b 3bvs1b 3dvs3c 3evs1b df Constraints df df df df df df df df df df df df df df df 4vs1b df df
TableS2c Model comparison ACEwithshared environmental transmissionvs 1b Test Phenotype df Constraints Numberofparameterssaturatedmodelwithconstraints(model1b):25 NumberofparametersACEmodelwithCT:17 r Numberofparameterssaturatedmodelwithconstraints:23 NumberofparametersACEmodelwithCT:17 r Numberofparameterssaturatedmodelwithconstraints:22 NumberofparametersACEmodelwithCT:13
ACDEvs1b r Numberofparameterssaturatedmodelwithconstraints:25 NumberofparametersACDEmodel:17 Numberofparameterssaturatedmodelwithconstraints:23 NumberofparametersACEmodelwithCT:17 Numberofparameterssaturatedmodelwithconstraints:22 NumberofparametersACEmodelwithCT:12
ADEvsACDE ACEvsACDE AEvsACDE df df df df df df
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