The Leading Formulators Workshop For Personal Care Ingredients Skincare

Transcript

1 The Leading Formulators Workshop For Personal Care Ingredients Skincare

2 Formulation number: MAS I Cetearyl Olivate (and) Sorbitan Olivate OLIVEM Emulsifier II Water up to III Preservative a.n. Perfume a.n. PROCEDURE: Heat phase II at C. Add the flakes of Olivem 1000 (phase I) directly into the warm water, under magnetic stirring. Stir for 5 minutes and then homogenize (e.g. SILVERSON/ULTRA-TURRAX/ ) for 1 minute. Cool down the temperature, under very slow stirring and add phase III below 40 C.

3 Formulation number: CPD Cetearyl Olivate (and) Sorbitan Olivate OLIVEM Emulsifier/ Liquid Crystal Maker I Cetyl Palmitate (and) Sorbitan Palmitate (and) Sorbitan Olivate OLIWAX LC 1.00 Stabilizing Agent Cetearyl Alcohol 1.00 Stabilizing Agent Triticum Vulgare (Wheat) Germ Oil 5.00 Emollient Caprilic/Capric Trigliceride 2.00 Emollient Lecithin (and) Tocopherol (and) Ascorbyl Palmitate (and) Citric Acid 0.05 Antioxidant II Dimethicone Emollient III Water up to Glycerin 5.00 Humectant Carbomer Carbopol Thickener IV Preservative a.n. Preservative Perfume a.n. Perfume PROCEDURE: Prepare and heat phase I and phase III separately; Disperse the carbomer in the phase III using a suitable dispersion unit (e.g. SILVERSON/ULTRA-TURRAX/ ); Add phase I to phase III under agitation at 75 C, homogenize for few minutes; Add phase II (Dimethicone); Cool down the temperature, under gentle stirring; Add phase IV below 40 C.

4 Formulation number: CPD Cetyl Palmitate (and) Sorbitan Palmitate (and) Sorbitan Olivate OLIWAX LC 1.00 Stabilizing Agent I Cetearyl Alcohol 1.00 Stabilizing Agent Triticum Vulgare (Wheat) Germ Oil 5.00 Emollient Caprilic/Capric Trigliceride 2.00 Emollient Lecithin (and) Tocopherol (and) Ascorbyl Palmitate (and) Citric Acid 0.05 Antioxidant II Dimethicone Emollient III Water up to Cetearyl Olivate (and) Sorbitan Olivate OLIVEM Emulsifier/ Liquid Crystal Maker Glycerin 5.00 Humectant Carbomer Carbopol Thickener IV Preservative a.n. Preservative Perfume a.n. Perfume PROCEDURE: Prepare phase I and phase III separately; Heat phase III at C (without Olivem 1000); Disperse the carbomer in the phase III using a suitable dispersion unit (e.g. SILVERSON/ULTRA-TURRAX/ ); Add the flakes of Olivem 1000 into the phase III under magnetic stirring; Stir for few minutes and then homogenize (e.g. SILVERSON/ULTRA-TURRAX/ ) for 1 minute; Add phase I to phase III under agitation at 75 C, homogenize for few minutes; Add phase II (Dimethicone); Cool down the temperature, under gentle stirring; Add phase IV below 40 C.

5 Formulation number: NAD B Cetearyl Olivate (and) Sorbitan Olivate OLIVEM Emulsifier/Liquid Crystal Promoter Ethylhexyl Olivate SENSOLENE 5.00 Emollient I Hydrogenated Olive Oil (and) Olea Europaea (Olive) Fruit Oil (and) Olea Europaea (Olive) Oil Unsaponifiables OLIWAX 0.50 Stabilizing Agent Butyrospermum Parkii (Shea) Butter 2.00 Emollient Teobroma Cacao (Cocoa) Seed Butter 1.00 Emollient Simmondia Chinensis (Jojoba) Seed Oil 1.00 Emollient Triticum Vulgare (Wheat) Germ Oil 2.00 Emollient Lecithin (and) Tocopherol (and) Ascorbyl Palmitate (and) Citric Acid Water 0.05 Antioxidant up to II Glycerin 3.00 Humectant Xanthan Gum 0.40 Thickener Microcristalline Cellulose, Carboxymethyl Cellulose 0.80 Thickener III Preservative a.n. Perfume a.n. PROCEDURE: Prepare Phase I and II separately and warm them up to 75 C and disperse thickeners using a suitable dispersion unit (e.g. ULTRA TURRAX, SILVERSON, ); Add Phase I to phase II under agitation (at 75 C), homogenize for a few minutes; Cool down under very low stirring; Add Phase III under 40 C.

6 Formulation number: CPD Cetearyl Olivate (and) Sorbitan Olivate OLIVEM Emulsifier/Liquid Crystal Promoter Hydrogenated Olive Oil (and) Olea Europaea (Olive) Fruit Oil (and) Olea Europaea (Olive) Oil Unsaponifiables OLIWAX 0.50 Stabilizing Agent I Butyrospermum Parkii (Shea) Butter 2.00 Emollient Teobroma Cacao (Cocoa) Seed Butter 1.00 Emollient Simmondia Chinensis (Jojoba) Oil 1.00 Emollient Triticum Vulgare (Wheat) Germ Oil 2.00 Emollient Lecithin (and) Tocopherol (and) Ascorbyl Palmitate (and) Citric Acid Water 0.05 Antioxidant up to II Glycerin 3.00 Humectant Xanthan Gum 0.40 Thickener Microcristalline Cellulose, Carboxymethyl Cellulose 0.80 Thickener III Preservative a.n. Preservative Perfume a.n. Perfume PROCEDURE: Prepare Phase I and II separately and warm them up to 75 C and disperding thickeners using a suitable dispersion unit (e.g. ULTRA TURRAX, SILVERSON, ); Add Phase I to phase II under agitation (at 75 C), homogenize for a few minutes; Cool down under gentle stirring; Add Phase III at 40 C.

7 Formulation number: NAD Ceteayl Olivate (and) Sorbitan Olivate OLIVEM Emulsifier/Liquid Crystal Maker Ethylhexyl Olivate SENSOLENE 2.00 Emollient I Cetyl Palmitate (and) Sorbitan Plamitate (and) Sorbitan Olivate OLIWAX LC 1.50 Stabilizing Agent Dicaprylyl Carbonate 1.50 Emollient Tetradibutyl Pentaerithryl Hidroxyhidrocinnamate 0.10 Antioxidant Agent Water up to II Glicerin 0.50 Humectant Ammonium Acryloyldimethyltaurate/VP Copolymer 1.20 Thickener Salicilic Acid 0.15 Antibacterial Agent III Cyclomethicone 0.50 Solubilising Agent Prunus Amygdalus Dulcis(Sweet Almond) Shell Powder, Corylus Avellana (Hazel) Shell Powder Granuli Vegetali G Exfoliating Agent Olea Europaea (Olive) Leaf Extract (and) water EUROL BT 0.50 Active Ingredient IV Preservative a.n. Preservative Perfume a.n. Perfume PROCEDURE: Prepare Phase I and II separately; Disperse thickener in the water phase at 75 C using a suitable dispersion unit (e.g. ULTRA TURRAX, SILVERSONE, ); Add Phase I to Phase II under agitation at 75 C using a suitable dispersion unit (e.g. ULTRA TURRAX, SILVERSONE, ), homogenize for few minutes; Then start cooling down; Add ingredients one by one of Phase III; At 40 C add Phase IV under gentle stirring;

8 Formulation number: MAS Ceteareth-6 Olivate OLIVEM Emulsifier Cetearyl Olivate (and) Sorbitan Olivate OLIVEM Emulsifier/ Liquid Crystal Promoter Cetearyl Alcohol 3.00 Stabilizing Agent I Dicaprylyl Carbonate 5.00 Emollient Pentaerhytrityl Distearate 1.00 Stabilizing Agent Ethylhexyl Methoxycinnamate 0.50 UVB Filter Isononyl Isononanoate 2.00 Emollient Butyl Methoxydibenzoylmethane 0.50 UVA Filter Water up to Glycerin 3.00 Humectant II Propylene Glycol 0.50 Humectant Allantoin 0.10 Active Ingredient Xanthan Gum 0.50 Thickener Preservative Perfume III Tocopheryl Acetate 0.10 Active Ingredient Panthenol 0.50 Active Ingredient a.n. a.n. Olea Europaea (Olive) Leaf Extract and Water EUROL BT 0.20 Free-Radicals Scavenger/ Antioxidant PROCEDURE: Prepare phase I and II separately, disperse the polymer in the water phase using a suitable dispersion unit (e.g. SILVERSON/ULTRA-TURRAX/ ); then warm it up to 75 C; Add phase I to phase II under agitation at 75 C, homogenize for few minutes; Cool down the temperature, under gentle stirring; Add phase III below 40 C.

9 Formulation number: NAD B Ceteayl Olivate (and) Sorbitan Olivate OLIVEM Emulsifier/Liquid Crystal Maker Ethylhexyl Olivate SENSOLENE 1.00 Emollient I Hydrogenated Olive Oil (and) Olea Europaea (Olive) Fruit Oil (and) Olea Europaea (Olive) Oil OLIWAX 1.50 Stabilizing Agent Unsaponifiables Persea Gratissima (Avocado) Butter 0.50 Emollient Olea Europaea (Olive) Fruit Oil 3.00 Emollient Gossypiun Cotton Seed Oil 2.00 Emollient Water up to II Glicerin 2.00 Humectant Ammonium Acryloyldimethyltaurate/VP Copolymer 0.30 Thickener III Triclosan 0.15 Antibacterial Agent Ethanol 0.50 Solubilising Agent Disodium Lauriminodipropionate Tocopherol Vital ET 0.50 Antioxidant Agent Phosphates IV Preservative a.n. Preservative Perfume a.n. Perfume PROCEDURE: Prepare Phase I and II separately; Disperse thickener in the water phase at 75 C using a suitable dispersion unit (e.g. ULTRA TURRAX, SILVERSONE, ); Add Phase I to Phase II under agitation at 75 C using a suitable dispersion unit (e.g. ULTRA TURRAX, SILVERSONE, ), homogenize for few minutes; Then start cooling down; Prepare Phase III dispersing triclosan into ethanol and add to the system; At 40 C add Phase IV under gentle stirring;

10 Formulation number: NAD Ceteareth-6 Olivate OLIVEM Emulsifier Ethylhexyl Olivate SENSOLENE 3.00 Emollient Hydrogenated Olive Oil (and) Olea Europaea (Olive) Fruit Oil (and) Olea Europaea (Olive) Oil Unsaponifiables OLIWAX 1.00 Stabilizing Agent I Dicaprylyl Carbonate 3.00 Emollient Olea Europaea (Olive) Fruit Oil 2.00 Emollient Caprilic/Capric Trigliceride 2.00 Emollient Triticum Vulgare (Wheat) Germ Oil 2.00 Emollient Glycine Soya (Soybean) Oil 2.00 Emollient Cetearyl Alcohol 1.00 Stabilizing Agent Water up to II Glycerin 3.00 Humectant Ammonium Acryloyldimethyltaurate/VP Copolymer 0.50 Thickener III Dimethicone 1.00 Emollient Preservative a.n. Preservative IV Perfume a.n. Olea Europaea (Olive) Leaf Extract and Water EUROL BT 0.50 Free-Radicals Scavenger/ Antioxidant PROCEDURE: Prepare Phase I (without Dimethicone) and II separately and warm them up to 75 C and disperding the Ammonium Acryloyldimethyltaurate/VP Copolymer using a suitable dispersion unit (e.g. ULTRA TURRAX, SILVERSON, ); Add Phase I to phase II under agitation (at 75 C), homogenize for a few minutes; Add the Dimethicone and homogenize for few minutes; Cool down under gentle stirring; Add Phase IV at 40 C.

11 Formulation number: NAD A I Ceteareth-6 Olivate OLIVEM Emulsifier Peg-4 Olivate OLIVEM Co-Emulsifier Hydrogenated Olive Oil (and) Olea Europaea (Olive) Fruit Oil (and) Olea Europaea (Olive) Oil Unsaponifiables Cetyl Palmitate (and) Sorbitan Palmitate (and) Sorbitan Olivate OLIWAX 3.00 Stabilizing Agent OLIWAX LC 3.00 Stabilizing Agent Multifunctional Ethylhexyl Olivate SENSOLENE 5.00 Lipid Cetylstearilic Alcohol 2.00 Stabilizing Agent Butyrospermum Parkii 3.00 Emollient Theobroma Cacao (Cocoa) Seed Butter 3.00 Emollient II Dimethicone 1.00 Emollient Water Up to III Glycerin 2.00 Humectant Xanthan Gum 0.30 Thickener Preservative a.n. Preservative IV Perfume a.n. Perfume Tocopheryl Acetate 0.20 Active Ingredient PROCEDURE: Prepare phase I and III separately, and warm them up to 75 C; Disperse the thickener using a suitable dispersion unit (e.g. ULTRA TURRAX, SILVERSON, ); Add phase I to phase III under agitation at 75 C using the same suitable dispersion unit (e.g. ULTRA TURRAX, SILVERSON, ); homogenize for few minutes; Add phase II to this system under agitation and homogenize for few minutes; Cool down under very gentle stirring to 40 C; At 40 C add Phase IV under very gentle stirring.

12 Formulation number: CPD Cetearyl Olivate (and) Sorbitan Olivate OLIVEM Emulsifier/ Liquid Crystal Promoter Cetyl Palmitate (and) Sorbitan Palmitate (and) Sorbitan Olivate OLIWAX LC 1.00 Stabilizing Agent I Ethyhexyl Olivate SENSOLENE 2.00 Emollient C Alkyl Benzoate 2.00 Emollient Cetearyl Alcohol 1.00 Stabilizing Agent Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine 5.00 UVB and UVA Filter Ethylhehyl Methoxycinnamate 7.00 UVB Filter Octocrylene 7.00 UVB e UVA Filter Agua up to II Glycerin 3.00 Humectant Panthenol 1.00 Active Ingredient Sodium Carbomer 0.30 Thickener III Preservative a.n. Preservative Perfume a.n. Perfume PROCEDURE: Prepare Phase I and II separately, warm them up to 75 C; Dispersing the Sodium Carbomer in the water phase with a suitable dispersion unit (ULTRA TURRAX, SILVERSON, ): Add Phase I to Phase II under agitation (at 75 C), homogenize for few minutes; Cool down under gentle stirring; Add Phase III at 40 C.

13 Prediction of sun protection factor and UVA Parameters REGION: Global COMPOSITION: INCI Name USAN Name Abbrv. % Octocrylene Octocrylene OCR 7 Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine (Tinorsob S) Bemotrizinol BEMT 5 Ethylhexyl Methoxycinnamate Octinoxate EHMC 5 Total 19 Results Calculated SPF 33.2 Filter Efficiency 1.75 UVA/PF (PPD) 8.6 Australian Standard Pass Critical Wavelength 367 UVA/UVB Ratio 0.5 JCIA PA+++ Star Rating ** Reference: 1. Herzog B, Prediction of Sun Protection Factors and UVA Parameters by Calculation of UV Transmissions Through Sunscreen Films of Inhomogenous Surface Structure, Chapter 44 in: Sunscreens: Regulations and Commercial Development (3rd edition), Edited by N. Shaath. Cosmetic Science and Technology Series, Vol 28; Taylor & Francis Group, Boca Raton, FL, 2005, p

14 Formulation number: CPD Sorbitan Olivate OLIVEM 900 SP 2.00 Co-Emulsifier Cetyl PEG-PPG-10/1 Dimethicone 2.00 Emulsifier I Cyclomethicone 5.00 Emollient Ethylhexyl Olivate SENSOLENE 2.00 Emollient Zinc Oxide (and) C12-15 Alkyl Benzoate (and) Isostearic acid and Polyhydroxy stearic acid Zinclear IM 50AB UV Filter Water up to II Glycerin 2.00 Humectant Magnesium Sulphate 1.00 Stabilizing Agent Olea Europaea (Olive) Leaf Extract (and) Water EUROL BT 0.50 Active Ingredient III Preservative a.n. Perfume a.n. PROCEDURE: Prepare phase I and II (without Cyclomethicone) separately and warm them up to 75 C. When both phases are ready add the Cyclomethicone to the phase I and then add very slowly a little quantity of the phase II to the phase I and homogenize till the water is completely incorporated; then add another little quantity of watery phase and so on, in the same way. Cool down the temperature under gentle stirring. Add phase III at room temperature.

15 Formulation number: CPD Cetearyl Olivate (and) Sorbitan Olivate OLIVEM Emulsifier/ Liquid Crystal Promoter Ceteareth-6 Olivate OLIVEM Emulsifier Sorbitan Olivate OLIVEM 900 SP 1.00 Active Ingredient Ethyhexyl Olivate SENSOLENE 2.00 Emollient I Dibutyl Adipate 3.00 Emollient Octocrylene 5.00 UVB and UVA filter Diethylamino Hydroxybenzoyl Hexyl Benzoate 2.00 UVA filter Ethylhehyl Methoxycinnamate UVB filter Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine 2.00 UVB and UVA filter Water Up to II Glycerin 3.00 Humetant Sodium Carbomer 0.30 Thickener Methylene Bis-Benzotriazolyl Tetramethylbutylphenol 6.00 UV Filter III Preservative a.n. Preservative Perfume a.n. Perfume PROCEDURE: Prepare Phase I and II separately, warm them up to 75 C; Dispersing the Sodium Carbomer in the water phase with a suitable dispersion unit (ULTRA TURRAX, SILVERSON, ): Add Phase I to Phase II under agitation (at 75 C), homogenize for few minutes; Cool down under gentle stirring; Add Phase III at 40 C.

16 Prediction of sun protection factor and UVA Parameters REGION: Global COMPOSITION: INCI Name USAN Name Abbrv. % Octocrylene Octocrylene OCR 5 Diethylamino Hydroxybenzoyl Hexyl Benzoate - DHHB 2 Ethylhexyl Methoxycinnamate Octinoxate EHMC 10 Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine (Tinosorb S) Bemotrizinol BEMT 2 Methylene Bis-Benzotriazolyl Tetramethylbutylphenol Bisoctrizole MBBT 6 (Tinosorb, M active) Total 25 Results Calculated SPF 51.3 Filter Efficiency 2.05 UVA/PF (PPD) 23.8 Australian Standard Pass Critical Wavelength 379 UVA/UVB Ratio 0.63 JCIA PA+++ Star Rating *** Reference: 1. Herzog B, Prediction of Sun Protection Factors and UVA Parameters by Calculation of UV Transmissions Through Sunscreen Films of Inhomogenous Surface Structure, Chapter 44 in: Sunscreens: Regulations and Commercial Development (3rd edition), Edited by N. Shaath. Cosmetic Science and Technology Series, Vol 28; Taylor & Francis Group, Boca Raton, FL, 2005, p

17 Formulation number: CPD Cetearyl Olivate (and) Sorbitan Olivate OLIVEM Emulsifier/ Liquid Crystal Promoter Sorbitan Olivate OLIVEM 900 SP 1.00 Active Ingredient Ethyhexyl Olivate SENSOLENE 2.00 Emollient I Caprilic/Capric Trigliceride 2.00 Emollient Ethylhexyl Salicylate 5.00 UVB filter Diethylamino Hydroxybenzoyl Hexyl Benzoate 3.00 UVA filter Ethylhehyl Methoxycinnamate 6.00 UVB filter Zinc Oxide Z-Cote MAX (Basf) 3.00 UVB and UVA filter Water Up to II Glycerin 3.00 Humettant Xanthan Gum 0.50 Thickener Microcrystalline Cellulose (and) Carboxymethyl Cellulose 1.50 Stabilizing Agent III Preservative a.n. Preservative Perfume a.n. Perfume PROCEDURE: Prepare Phase I and II separately, warm them up to 75 C; Dispersing the Xanthan Gum and Microcrystalline Cellulose, Carboxymethyl Cellulose in the water phase with a suitable dispersion unit (ULTRA TURRAX, SILVERSON, ): Add Phase I to Phase II under agitation (at 75 C), homogenize for few minutes; Cool down under gentle stirring; Add Phase III at 40 C.

18 Crystal Skin!"#$%&"'!"()*+,-$!*. EVERYTHINGSKINNEEDS Olivem 1000 Crystal Skin is the first emulsifying active ingredient. One important role of the stratum corneum barrier function is to protect us against environmental stress factors. Numerous clinical studies have demonstrated the efficacy of the Olivem 1000 Crystal Skin in increasing the integrity of the cutaneous barrier. The homeostatic action of the skin-compatible liquid crystals, generated by Olivem 1000 Crystal Skin, allows to maintain optimal physiological function of the skin barrier ensuring maximal protection from harsh environmental damage. Patented by B&T - Made in Italy liquid crystals

19 This document, or any answers or information provided herein by BASF, does not constitute a legally binding obligation of BASF. While the descriptions, designs, data and information contained herein are presented in good faith and believed to be accurate, it is provided for your guidance only. Because many factors may affect processing or application/use, we recommend that you make tests to determine the suitability of a product for your particular purpose prior to use. It does not relieve our customers from the obligation to perform a full inspection of the products upon delivery or any other obligation. NO WARRANTIES OF ANY KIND, EITHER EXPRESS OR IMPLIED, INCLUDING WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, ARE MADE REGARDING PRODUCTS DESCRIBED OR DESIGNS, DATA OR INFORMATION SET FORTH, OR THAT THE PRODUCTS, DESIGNS, DATA OR INFORMATION MAY BE USED WITHOUT INFRINGING THE INTELLECTUAL PROPERTY RIGHTS OF OTHERS. IN NO CASE SHALL THE DESCRIPTIONS, INFORMATION, DATA OR DESIGNS PROVIDED BE CONSIDERED A PART OF OUR TERMS AND CONDITIONS OF SALE.

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32 Moisturizing Soya Care Classic SC-DE/06/109/2 Phase A B C Trade Name Emulgade PL 68/50 Eumulgin SG Cosmedia SP Cetiol CC Cetiol OE Cetiol SB45 Cetiol PGL Water, demin. Glycerin Soy Bean Extract (Burgundy Botanical Extracts) DryFlo PC (National Starch) Perfume Preservative INCI Name Cetearyl Glucoside (and) Cetearyl Alcohol Sodium Stearoyl Glutamate Sodium Polyacrylate Dicaprylyl Carbonate Dicaprylyl Ether Butyrospermum Parkii(Shea Butter) extract Hexyldecanol (and) Hexyldecyl Laurate Aqua Glycerin Soy Isoflavones Aluminum Starch Octenylsuccinate Perfume Appearance Viscosity (Brookfield RVT, 23C, spindle 5, 10rpm) ph w/w % up to q.s. Opaque white cream 20,000 mpas 6.0 PROCEDURES 1. Heat phase A (oil phase) and phase B (water phase) to 78, separately. 2. Add phase A to phase B while stirring and mix with a suitable dispersion unit (e.g. with TK homomixer, at 5500 rpm, for 5 min). 3. Allow the emulsion to cool to 45 while gentle stirring in such a way that it remains in continuous motion. 4. Add phase C to the emulsion and mix with a suitable dispersion unit (e.g. with TK homomixer, at 5000 rpm, for 3 min). 5. Allow the emulsion to cool to 27 while gentle stirring in such a way that it remains in continuous motion. CONTACT: Yeah-Young Baek Yeah-Young.Baek@cognis.com Phone:

33 Advanced Performance Product SC-DE/07/070/15 Phase Trade Name A Emulgade PL 68/50 B C Eumulgin SG Cutina GMS V Cetiol OE Cetiol LC Myritol 331 Cegesoft PS 6 Cetiol SB 45 Water, demin. Aqua Glycerin Glycerin Keltrol T (CP Kelco) Xanthan gum Tapioca Starch(A&E Connock) Tapioca Starch HYHA 13 Hamamelis Virg Hydrolate d' Hamamelis (Fytosan) Herbalia Gingko Herbalia Grape Covi-OX T90 EU Ethanol INCI Name Cetearyl Glucoside (and) Cetearyl Alcohol Sodium Stearoyl Glutamate Glyceryl Stearate Dicaprylyl Ether Coco-Caprylate/caprate Cocoglycerides Vegetable Oil Butyrospermum Parkii (Shea butter) extract Panax Ginseng Root Extract(and)Maltodextrin(and)Silica Vitis Vinifera Seed Extract(and)Silica Tocopherol Ethanol Appearance Viscosity (Brookfield RVF, 23C, spindle T-E, 4 rpm,helipath) ph w/w% up to Opaque brown cream 50,000 mpas 5.7 PROCEDURES 1. Heat phase A (oil phase) and phase B (water phase) to 78, separately. 2. Add phase A to phase B while stirring and mix with a suitable dispersion unit (e.g. with TK homomixer, at 5500 rpm, for 5 min). 3. Allow the emulsion to cool to 45 while gentle stirring in such a way that it remains in continuous motion. 4. Add phase C to the emulsion and mix with a suitable dispersion unit (e.g. with TK homomixer, at 5500 rpm, for 3 min). 5. Allow the emulsion to cool to 27 while gentle stirring in such a way that it remains in continuous motion. CONTACT: Yeah-Young Baek ( Yeah-Young.Baek@cognis.com / Phone: )

34 Moisture & Radiance BB (SPF 20) SC-KR/09/BBS20/6 Phase A B C D Trade Name INCI Name Eumulgin BA 25 Beheneth-25 Lameform TGI Polyglyceryl-3-diisostearate Cosmeida DC Hydrogenated Dimer Dilinoleyl / Dimethylcarbonate Copolymer Myritol GTEH Triethylhexanoin Cetiol B Dibutyl adipate Escalol 587(International specialty products) Ethylhexyl salicylate Escalol 597(International specialty products) Octocrylene Eusolex HMS (Merck) homosalate Uvinul A Plus (BASF) Diethylamino Hydroxybenzoyl Hexyl Benzoate Cetiol SUN Dicaprylyl Carbonate (and) Titanium Dioxide (and) Polyhydroxystearic Acid (and) Alumina (and) Stearic Acid (and) Dimethicone Cutina PES Pentaerythrityl distearate Cetiol Sensoft Propylheptyl Caprylate KF-6017 (Shin-Etsu) PEG-10 dimethicone DC-200f/100cs (Dow) Dimethicone Water,demin. Aqua Glycerin Glycerin Pharconix CPS (Ichimaru Pharcos Butylene glycol company) Veegum HV (RT Vanderbilt) Magnesium Aluminum Silicate Novaxan D (Archer Daniels Mildland) Xanthan gum TiO2(C ) (Sunjin) Titanium dioxide Talc JA 46 R (Asada milling) Talc Cosmedia PMMA V 12 Polymethyl Methacrylate Pigment complex iron oxides(yellow, red and black) Tinosorb M (Ciba) Methylene Bis-Benzotriazolyl Tetramethylbutylphenol w/w% up to Photonyl TM LS Arginine (and) Disodium Adenosine Triphosphate (and) Mannitol (and) Pyridoxine HCl (and) RNA (and) Histidine HCl (and) Phenylalanine (and) Tyrosine 1.00 Litchiderm LS 9704 Butylene Glycol (and) Litchi Chinensis Extract 1.00 Indinyl CA LS 8998 Aqua (and) Cassia Angustifolia Extract 1.00 Preservative, fragrance q.s. Appearance Opaque dark brown cream Viscosity (Brookfield RVDV-II pro, 23C, spindle T-C, 12rpm, Helipath) 26,000 mpas ph 7.8 PROCEDURES 1. Heat phase A (oil phase) and phase B (water phase) to 78, separately. 2. Add phase A to phase B while stirring and mix with a suitable dispersion unit (e.g. with TK homomixer, at 5500 rpm, for 5 min). 3. Add pre-dispersed phase C to the emulsion and mix with a suitable dispersion unit (e.g. with TK homomixer, at 5500 rpm, for 5 ~ 10 min). 4. Allow the emulsion to cool to 50 while gentle stirring in such a way that it remains in continuous motion. 5. Add phase D to the emulsion and mix with a suitable dispersion unit (e.g. with TK homomixer, at 5500 rpm, for 3 min). 6. Allow the emulsion to cool to 27 while gentle stirring in such a way that it remains in continuous motion. CONTACT: Yeah-Young Baek ( Yeah-Young.Baek@cognis.com / Phone: )

35 Sun Protection BB (SPF 50) SC-KR/09/BBS50/6 Phase A B C D Trade Name INCI Name w/w % Eumulgin BA 25 Beheneth Lameform TGI Polyglyceryl-3-diisostearate 1.50 Cosmedia DC Hydrogenated Dimer Dilinoleyl / Dimethylcarbonate 1.00 Copolymer Cetiol CC Dicaprylyl Carbonate 3.00 Cetiol B Dibutyl Adipate 5.00 Cutina PES Pentaerythrityl Distearate 1.00 Uvasorb HEB (3V) Diethylhexyl butamido triazone 2.50 Escalol 597(International specialty products) Octocrylene Tinosrob S (Ciba) Bis-ethylhexyloxyphenol methoxyphenyl triazine 2.00 Uvinul A plus (BASF) Diethylamino hydroxybenzoyl hexyl benzoate 7.00 KF-6017 (Shin-Etsu) PEG-10 dimethicone 0.50 DC 200f/100cs (Dow) Dimethicone 0.50 Water, demin. Aqua up to 100 Glycerin Glycerin 3.00 Pharconix CPS (Ichimaru Pharcos) Butylene glycol 5.00 Veegum HV (RT Vanderbilt) Magnesium aluminum silicate 1.00 Novaxan D (Archer Daniels Midland) Xanthan gum 0.40 TiO 2 (C ) (Sunjin) Titanium dioxide 7.64 Talc JA 46 R (Asada milling) Talc 2.00 Cosmedia PMMA V 12 Polymethyl Methacrylate 3.00 pigment complex iron oxides(yellow, red and black) 1.01 Tinosrob M (Ciba) Methylene bis-benzotriazolyl tetramethylbutylphenol DN-Age LS 9653 Water (and) Glycerin (and) Cassia Alata Leaf Extract 0.50 Sunactyl LS 9610 Mannitol (and) Pisum Sativum (Pea) Extract (and) Histidine HCl (and) Arginine (and) Cyclodextrin (and) Dextrin (and) Yeast Extract (and) Acetyl Tyrosine (and) Pyridoxine HCl (and) Khaya Senegalensis Bark Extract (and) Nicotinamide Adenine Dinucleotide (and) Disodium Succinate (and) Aspartic Acid 1.00 Photonyl TM LS Arginine (and) Disodium Adenosine Triphosphate (and) Mannitol (and) Pyridoxine HCl (and) RNA (and) Histidine HCl (and) Phenylalanine (and) Tyrosine 1.00 Preservatives, fragrance q.s. Appearance Opaque dark brown cream Viscosity (Brookfield RVDV-II pro, 23C, spindle T-C, 12rpm, Helipath) 25,700 mpas ph 7.8 PROCEDURES 1. Heat phase A (oil phase) and phase B (water phase) to 78, separately. 2. Add phase A to phase B while stirring and mix with a suitable dispersion unit(e.g. with TK homomixer, at 5500 rpm, for 5 min). 3. Add pre-dispersed phase C to the emulsion and mix with a suitable dispersion unit(e.g. with TK homomixer, at 5500 rpm, for 5 ~10 min). 4. Allow the emulsion to cool to 50 while gentle stirring in such a way that it remains in continuous motion. 5. Add phase D to the emulsion and mix with a suitable dispersion unit (e.g. with TK homomixer, at 5500 rpm, for 3 min). 6. Allow the emulsion to cool to 27 while gentle stirring in such a way that it remains in continuous motion. CONTACT: Yeah-Young Baek ( Yeah-Young.Baek@cognis.com / Phone: )

36 Silky Lotion SC-GB/07/08C Phase Trade Name INCI Name A Dehyquart L 80 Dicocoylethyl Hydroxyethylmonium Methosulfate (and) Propylene Glycol Cetiol CC Dicaprylyl Carbonate Cetiol SN Cetearyl Isononanoate Eutanol G16 Hexyldecanol B Water, demin. Aqua Pharconix CPS Butylene glycol (Ichimaru Pharcos) Glycerin Glycerin Ultragel 300 Polyquarternium-37 C Preservative, perfume Appearance Viscosity (Brookfield RVF, 23C, spindle 5, 10rpm) ph w/w % up to q.s. Opaque white lotion 22,000 mpas 4.0 PROCEDURES 1. Disperse phase A and B with a suitable dispersion unit at room temperature. 2. Add phase A to phase B while stirring and mix with a suitable dispersion unit (e.g. with TK homomixer, at 5000rpm, for 3min), at room temperature. 3. Add phase C to the emulsion while stirring and mix with a suitable dispersion unit (e.g. with TK homomixer, at 5000 rpm, for 2 min). CONTACT: Yeah-Young Baek Yeah-Young.Baek@cognis.com Phone:

37 Argan anti-ageing Cream SC-GB/07/07 C Phase A B C Trade Name INCI Name Eumulgin SG Sodium Stearoyl Glutamate Cetiol Sensoft Propylheptyl Caprylate Cegesoft PFO Passiflora Incarnata Seed Oil Cetiol SB 45 Butyrospermum Parkii (Shea) Butter Cosmedia SP Sodium Polyacrylate DC 200f (Dow-Corning) Dimethicone Keltrol T (CP Kelco) Xanthan Gum Water,demin. Aqua Glycerin Glycerin Argatensyl LS 9735 Aqua (and) Argania Spinosa Extract (and) Sodium Cocoyl Glutamate (and) Carbomer Preservative, fragrance Appearance Viscosity (Brookfield RVF, 23C, spindle TE, 4rpm, Helipath) ph w/w % up to q.s. Opaque slightly yellow cream 100,000 mpas 6.5 PROCEDURES 1. Stirring phase A and phase B at room temperature. 2. Add phase A to phase B while stirring and mix with a suitable dispersion unit (e.g. with TK homomixer, at 5500rpm, for 5min), at room temperature. 3. Add phase C to the emulsion while stirring and mix with a suitable dispersion unit (e.g. with TK homomixer, at 5000 rpm, for 2 min). CONTACT: Yeah-Young Baek Yeah-Young.Baek@cognis.com Phone:

38 Long-lasting Moisturizing Cream SC-KR/07/ESA/10 Phase A B C Trade Name Emulgade Sucro Plantacare 818 UP Lanette 22 Cutina GMS V Cegesoft SH Cetiol CC Cetiol SN Cetiol PGL INCI Name Sucrose Polystearate (and) Hydrogenated Polyisobutene Coco-Glucoside Behenyl Alcohol Glyceryl Stearate Shorea Stenoptera Seed Butter Dicaprylyl Carbonate Cetearyl Isononanoate Hexyldecanol (and) Hexyldecyl Laurate Cegesoft PFO Passiflora Incarnata Seed Oil Fitoderm VG Squalane Cosmedia SP Sodium Polyacrylate DC 200f/6cs (Dow-Corning) Dimethicone Water, demin. Aqua Pharconix CPS(Ichimaru Pharcos) Butylene glycol Glycerin Glycerin 1% Aronvis MX (Nihon junyaku) Sodium polyacrylate Natural extract BP 20(Finnfeeds Betaine Finland) EDTA-2Na Disodium EDTA Copherol 1250 C Tocopheryl Acetate Preservative/fragrance Appearance Viscosity (Brookfield RVDV II-pro, 23C, spindle TC, 10rpm, Helipath) ph w/w % up to q,s. Opaque white cream 28,000 mpas 6.5 PROCEDURES 1. Heat phase A (oil phase) and phase B (water phase) to 78, separately. 2. Add phase A to phase B while stirring and mix with a suitable dispersion unit (e.g. with TK homomixer, at 5500 rpm, for 5 min). 3. Allow the emulsion to cool to 45 while gentle stirring in such a way that it remains in continuous motion. 4. Add phase C to the emulsion and mix with a suitable dispersion unit (e.g. with TK homomixer, at 5500 rpm, for 2 min). 5. Allow the emulsion to cool to 27 while gentle stirring in such a way that it remains in continuous motion. CONTACT: Yeah-Young Baek ( Yeah-Young.Baek@cognis.com / Phone: )

39 Superior Performance Product SC-DE/09/068/4 Phase A B C Trade Name Eumulgin SG Emulgade SUCRO Cutina PES Cutina HVG Lanette O Cosmedia SP Cetiol CC Cetiol 868 Cetiol SN Cegesoft PFO Water, demin. Glycerin Keltrol T (CP Kelco) Aloe Vera Gel (Burgundy Botanical Extracts) Indinyl CA LS 8998 Copherol F 1300C Perfume, Preservative INCI Name Sodium Stearoyl Glutamate Sucrose Polystearate (and) Hydrogenated Polyisobutene Pentaerythrityl Distearate Glyceryl Stearte Cetearyl Alcohol Sodium Polyacrylate Dicaprylyl Carbonate Ethylhexyl Stearate Cetearyl Isononanoate Passiflora Incarnata Seed oil Aqua Glycerin Xanthan Gum Aloe Barbadensis Leaf Extract Water (and) Cassia Angustifolia Seed Polysaccharide Tocopherol Appearance Viscosity (Brookfield RVF, 23C, spindle T-E, 4rpm, Helipath) ph w/w% up to q.s. Opaque white cream 275,000 mpas 6.0 PROCEDURES 1. Heat phase A(oil phase) and phase B(water phase) to 78, separately. 2. Add phase A to phase B while stirring and mix with a suitable dispersion unit (e.g. with TK homomixer, at 5500 rpm, for 5 min). 3. Allow the emulsion to cool to 45 while gentle stirring in such a way that it remains in continuous motion. 4. Add phase C to the emulsion and mix with a suitable dispersion unit (e.g. with TK homomixer, at 5500 rpm, for 3 min). 5. Allow the emulsion to cool to 27 while gentle stirring in such a way that it remains in continuous motion. CONTACT: Yeah-Young Baek ( Yeah-Young.Baek@cognis.com / Phone: )

40 Whitening BB (SPF 30) SC-KR/09/BBS30/6 Phase Trade Name INCI Name w/w % A Eumulgin BA 25 Beheneth Lameform TGI Polyglyceryl-3-diisostearate 1.50 Cosmedia DC Hydrogenated Dimer Dilinoleyl / Dimethylcarbonate Copolymer 1.00 Cetiol CC Dicaprylyl Carbonate 3.00 Myritol GTEH Triethylhexanoin 4.00 Cetiol B Dibutyl Adipate 3.00 Escalol 587(International specialty products) Ethylhexyl salicylate 6.00 Escalol 597(International specialty products) Octocrylene 6.00 Tinosorb S (Ciba) Bis-ethylhexyloxyphenol methoxyphenyl triazine 2.00 Uvinul A plus (BASF) Diethylamino hydroxybenzoyl hexyl benzoate 5.00 Cutina PES Pentaerythrityl Distearate 2.00 KF-6017 (Shin-Etsu) PEG-10 dimethicone 0.50 DC-200f/100cs (Dow-Corning) Dimethicone 0.50 B Water, demin. Aqua up to 100 Glycerin Glycerin 3.00 Pharconix CPS (Ichimaru Pharcos) Butylene glycol 5.00 Veegum HV (RT Vanderbilt) Magnesium aluminum silicate 1.00 Novaxan D (Archer Daniels Midland) Xanthan gum 0.40 C TiO2(C ) (Sunjin) Titanium dioxide 7.64 Talc JA 46 R (Asada milling) Talc 2.00 Cosmedia PMMA V 12 Polymethyl Methacrylate 3.00 pigment complex iron oxides(yellow, red and black) 1.01 D Tinosorb M (Ciba) Methylene Bis-Benzotriazolyl Tetramethylbutylphenol 6.00 Sunactyl LS 9610 Mannitol (and) Pisum Sativum (Pea) Extract (and) Histidine HCl (and) Arginine (and) Cyclodextrin (and) Dextrin (and) Yeast Extract (and) Acetyl Tyrosine (and) Pyridoxine HCl (and) Khaya Senegalensis Bark Extract (and) Nicotinamide Adenine Dinucleotide (and) Disodium Succinate (and) Aspartic Acid 1.00 Actiwhite TM LS 9808 Water (and) Glycerin (and) Sucrose Dilaurate (and) Polysorbate 20 (and) Pisum Sativum (Pea) Extract 1.00 Biophytex LS 9832 Water (and) Butylene Glycol (and) Panthenol (and) Escin (and) Glycerin (and) Ruscus Aculeatus Root Extract (and) Ammonium Glycyrrhizate (and) Centella Asiatica Extract (and) Hydrolyzed Yeast Protein (and) Calendula Officinalis Flower Extract 1.00 Preservatives, fragrance q.s. Appearance Opaque dark brown cream Viscosity (Brookfield RVDV-II pro, 23C, spindle T-C, 12rpm, Helipath) 22,000 mpas ph 7.8 PROCEDURES 1. Heat phase A (oil phase) and phase B (water phase) to 78, separately. 2. Add phase A to phase B while stirring and mix with a suitable dispersion unit(e.g. with TK homomixer, at 5500 rpm, for 5 min). 3. Add pre-dispersed phase C to the emulsion and mix with a suitable dispersion unit(e.g. with TK homomixer, at 5500 rpm, for 5 ~10 min). 4. Allow the emulsion to cool to 50 while gentle stirring in such a way that it remains in continuous motion. 5. Add phase D to the emulsion and mix with a suitable dispersion unit (e.g. with TK homomixer, at 5500 rpm, for 3 min). 6. Allow the emulsion to cool to 27 while gentle stirring in such a way that it remains in continuous motion. CONTACT: Yeah-Young Baek ( Yeah-Young.Baek@cognis.com / Phone: )

41 Multiple Emulsion SC-KR/07/ME/10 Phase I-A I-B II-A II-B II-C Trade Name Dehymyls PGPH Lameform TGI Cetiol CC Cetiol Sensoft INCI Name Polyglyceryl-2 Dipolyhydroxystearate Polyglyceryl-3-diisostearate Dicaprylyl Carbonate Propylheptyl Caprylate w/w% Cetiol B Dibutyl Adipate 6.00 Cetiol SN Cetearyl Isononanoate 5.00 Cegesoft SH Shorea Stenoptera Seed Butter 3.00 Water, demin. Aqua up to 100 Glycerin Glycerin 3.00 MgSO 4 Magnesium sulfate 0.50 preservative q.s Water, demin. Aqua up to 100 OriStar DPLG (Orient Dipropylene Glycol 4.00 Stars) Eumulgin O 5 Oleth Cosmedia SP Sodium Polyacrylate % Pemulen TR-2 Acrylate/C10-13 alkyl acrylate crosspolymer (Noveon) EDTA-2Na Disodium EDTA % KOH Potassium hydroxide 1.80 Preservative, fragrance q.s. Appearance Opaque white cream Viscosity (Brookfield RVDV II-pro, 23C, spindle T-C, 10rpm, Helipath) 14,000 mpas PROCEDURES 1. Heat phase I-A (oil phase) and phase I-B (water phase) to 78, separately. 2. Add slowly phase I-B to phase I-A while stirring and mix with a suitable dispersion unit (e.g. with TK homomixer, at 5000 rpm, for 5 min). 3. Allow the emulsion to cool to 27' while gentle stirring in such a way that it remains in continuous motion. 4. Disperse phase II-A with a suitable dispersion unit at room temperature. 5. Add phase II-B to the phase II-A while gentle stirring and disperse with a suitable dispersion unit. 6. Add Phase II-C to the phase II-A and mix with a suitable dispersion unit. 7. Heat 20% of the pre-base I (W/O emulsion) and 80% of the pre-base II (polymer dispersed water phase containing emulsifier) to Add the pre-base I to the pre-base II slowly while stirring and mix with a suitable dispersion unit (e.g. with TK homomixer, at 3000 rpm, for 5 min) 9. Allow the emulsion to cool to 27' while gentle stirring in such a way that it remains in continuous motion. CONTACT: Yeah-Young Baek ( Yeah-Young.Baek@cognis.com / Phone: )

42 100% NATURAL REGENERATING SKIN CREAM C3074 Product / INCI Name Functionality % w/w REVITELIX TM Regeneration & (Echium Plantigenium Seed Oil) 1 Protection 5.00 CRODAMOL TM Light emollient with good GTCC (Caprylic/Capric Triglyceride) 1 lubricity 5.00 CRODACOL TM CS90EP (Cetyl Alcohol) 1 Viscosity builder 2.00 SEATONS ORGANIC GRAPESEED (Vitis Vinifera Seed Oil) 2 Light silky feel organic emollient 2.00 CRODACOL TM S95EP (Stearyl Alcohol) Viscosity builder 2.00 Water Deionised (Aqua) - To PRICERINE TM 9091 (Glycerin) 1 Humectant 3.00 ARLATONE TM V-175 (Sucrose Palmitate (and) Glyceryl Stearate (and) Glyceryl Stearate Citrate (and) Sucrose (and) Mannan (and) Xanthan Gum) 1 Naticide (Parfum) 3 O/W emulsifying and stabilising system. Fragrance with preservative boosting effect Dermofeel Toco 70 non-gmo (Tochopherol (and) Helianthus 2 Natural antioxidant 0.20 Annus (Sunflower) Seed Oil) Suppliers: 1: Croda 2: Dr Straetmans GmbH 3: Sinerga Method Premix Arlatone V-175 with Pricerine 9091, slowly add water with stirring, stir until fully hydrated. Separately combine oil phase and heat both oil and water phases to C. Add oil phase to water phase with stirring at 400 rpm. Homogenise for 2 minutes at rpm. Stir at rpm for 10 minutes. At 40 C add N aticide and Sinodor. Assess ph and adjust if necessary. Appearance: White cream, mousse like texture ph: Viscosity: 6320cP ±10% (Spgl 27, Rpm 20, 25 C) Stability: 3 45 C; 40 C; 25 C; 4 C and lig ht

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56 WISDOM OF THE ORIENT C10041 INTENSIVE CONDITIONING MASK This intensive conditioning mask will leave the hair feeling silky soft from the inside out. Crosilk Liquid is substantive and penetrates the hair, helping to prevent breakage and split ends, whilst Crosilkquat is highly substantive and leaves the surface of the hair feeling soft and adds body and texture. Apply to hair after shampooing and leave for 5 minutes before rinsing, alternatively for a more intensive treatment apply to hair, wrap in a towel and leave for 15 minutes before rinsing. Product / INCI Name Functionality % w/w CRODAMOL TM SS (Cetyl Esters) 1 Viscosity builder 2.00 INCROQUAT TM BEHENYL TMS-50 (Behentrimonium Methosulfate Cationic emulsifying and Cetyl Alcohol and Butylene Glycol) 1 agent 5.00 CRODACOL TM CS90EP (Cetyl Esters) 1 Viscosity builder 2.00 INCROMINE TM SB (Stearamidopropyl Dimethylamine) 1 Viscosity builder 1.00 Water deionised (Aqua) qs Citric acid ph adjuster qs CROSILK TM LIQUID (Aqua (&) Silk Amino Acids) 1 Moisturiser 0.50 CROSILKQUAT TM (Aqua (&) Cocodimonium Hydroxypropyl Silk Amino Moisturiser and Acids) 1 conditioning agent 0.50 PHYTOFLEUR TM Conditioning, JAPANESE CHERRY (Aqua (&) Glycerin (&) Prunus Serrulata Flower Extract) 2 moisturising and regenerating 0.50 Nipaguard MPA (Benzyl Alcohol (&) Methylparaben (&) 2 Propylparaben) Preservative 0.70 Fragrance Hot Pepper and Coconut Milk A (Parfum) 3 Fragrance 0.50 Suppliers:- 1: Croda Chemicals 2: Clariant 3: Ungerer Method Combine oil phase ingredients and heat to C. Heat water to C. Add water phase to oil phase with intensive stirring. Stir/cool to room temperature adding remaining ingredients below 40 C, ensuring the formulation is homogenous after each addition. Finally adjust ph to 4.5 if necessary. Appearance: A thick white emulsion ph: Viscosity: 38,000 mpa.s (Brookfield RVDV1, spindle 92, 5 rpm, 1 min) Stability: 3 months at 45 C, 40 C, 5 C, -5 C/40 C and room temperature.

57 DSM Nutritional Products Anti-aging Day Care Emulsion SPF= 24 Claims: Protects against UVA photoaging; Folic Acid protects DNA damage; Stay-C 50 provides powerful antioxidant action; Light and elegant texture Phase Ingredients INCI Name % w / w Supplier A PARSOL 1789 Butyl Methoxydibenzoylmethane (Avobenzone; USAN) PARSOL SLX Polysilicone PARSOL 340 Octocrylene (Octocrilene; USAN) dl-alpha -Tocopheryl Acetate Tocopheryl Acetate AMPHISOL K Potassium Cetyl Phosphate Estol 3650 Glyceryl Myristate Lanette 16 Cetyl Alcohol Butylated Hydroxytoluene BHT Dow Corning 200/100 cs Dimethicone Phenonip Phenoxyethanol & Methylparaben & Ethylparaben & Butylparaben & Propylparaben & Isobutylparaben DUB DIS Diisopropyl Sebacate Cetiol B Dibutyl Adipate Antaron V-220 VP/Eicosene Copolymer B Glycerin Glycerin Keltrol Xanthan Gum Dequest 2046 Pentasodium Ethylenediamine Tetramethylene Phosphonate D-Panthenol Panthenol Water dem. Aqua C Sodium Hydroxide 10% sol. Sodium Hydroxide 0.65 D Water dem. Aqua 5.00 Sodium Hydroxide 10% sol. Sodium Hydroxide 3.00 PARSOL HS Phenylbenzimidazole Sulfonic Acid (Ensulizole; USAN) Folic Acid Folic Acid STAY-C 50 Sodium Ascorbyl Phosphate Procedure 1 Heat part A to 85 C and stir until homogeneous. 2 Heat part B to 85 C and add to part A under agitation 3 Cool down the emulsion to 55 C and add part C. 4 When everything is homogenous add part D pre-heated to 50 C. Be sure that the ph of PARSOL HS solution is 7.0. If traces remain, add small quantities of the used neutralizing base until the particles are dissolved. Homogenize thoroughly and then with continued mixing cool down to ambient temperature. It is generally recommended to use vacuum while producing the emulsion. Technical Data ph: 7.53 Viscosity: cps (Brookfield, RV4,10 rpm) SPF in vivo: 24.2 In vitro UVAPF (Colipa 2007): - PA: +++ UVAPF/SPF (50 labelled); 0.33: - PFA: 9.3 Critical Wavelength: 374 nm Supplier DSM Nutritional Products Stearinerie Dubois Fils Croda GmbH CLARIANT GMBH International Specialty Produc Cognis Deutschland GmbH&Co.KG Merck KGaA CP Kelco Solutia Inc Dow Corning Corporation /001 Notes: For US (under new proposed final monograph), AP, EU, LA This information is based on our current knowledge and experience and is provided without representation or warranty. Use of this information shall be at your discretion and risk. Nothing herein relieves you from carrying out your own suitability determinations and tests. We disclaim any and all liability in connection with your product or its use. This information does not relieve you of your obligation to comply with all applicable laws and regulations and to observe all third party rights. DSM Nutritional Products, CH-4002 Basel, Switzerland

58 DSM Nutritional Products PARSOL SLX High Protection DSM 4 in vivo SPF 33 Sun Lotion with light texture and highly efficient UV filter combination Sunscreen with 3% PARSOL SLX, 4% PARSOL 1789 and 4% PARSOL HS Phase Ingredients INCI Name % w / w Supplier A PARSOL 1789 Butyl Methoxydibenzoylmethane (Avobenzone; USAN) PARSOL SLX Polysilicone Estol 3650 Glyceryl Myristate Lanette 16 Cetyl Alcohol Butylated Hydroxytoluene BHT Dow Corning 200/100 cs Dimethicone Phenonip Phenoxyethanol & Methylparaben & Ethylparaben & Butylparaben & Propylparaben & Isobutylparaben AMPHISOL K Potassium Cetyl Phosphate Paraffin Oil Mineral Oil DUB DIS Diisopropyl Sebacate Cetiol B Dibutyl Adipate Antaron V-220 VP/Eicosene Copolymer B Glycerin Glycerin Keltrol Xanthan Gum Dequest 2046 Pentasodium Ethylenediamine Tetramethylene Phosphonate Water dem. Aqua C Triethanolamine (T.E.A.) Triethanolamine D Water dem. Aqua Triethanolamine (T.E.A.) Triethanolamine PARSOL HS Phenylbenzimidazole Sulfonic Acid (Ensulizole; USAN) Procedure 1 Heat part A to 85 C while stirring. 2 Heat part B to 80 C and add to part A while stirring and homogenizing the emulsion. 3 Cool down the emulsion to 55 C and add part C. Be sure that the ph of the emulsion is 7.0. If traces remain, add small quantities of the used neutralizing base until the ph-value is at least Be sure that the ph of PARSOL HS solution is 7.0. If traces remain, add small quantities of the used neutralizing base until the particles are dissolved. Now add part D and homogenize intensively again. Then cool down to ambient temperature while mixing. It is generally recommended to use vacuum while producing the emulsion. Technical Data ph: 7.90 Viscosity: 8080 cps (Brookfield, RV4, 10 rpm) SPF in vivo*: 33 In vitro UVAPF (Colipa 2007): 10 UVAPF/SPF (30 labeled); 0.33: 0.33 Critical Wavelength: 377 nm * Three independent in vivo tests at two different institutes according to the International Method Supplier DSM Nutritional Products Solutia Inc Croda GmbH Stearinerie Dubois Fils Fluka Chemie AG CLARIANT GMBH Hänseler AG Cognis Deutschland GmbH&Co.KG International Specialty Products CP Kelco Merck KGaA Dow Corning Corporation /001 This information is based on our current knowledge and experience and is provided without representation or warranty. Use of this information shall be at your discretion and risk. Nothing herein relieves you from carrying out your own suitability determinations and tests. We disclaim any and all liability in connection with your product or its use. This information does not relieve you of your obligation to comply with all applicable laws and regulations and to observe all third party rights. DSM Nutritional Products, CH-4002 Basel, Switzerland

59 DSM Nutritional Products Skin Lightening Cream With STAY-C 50, Niacinamide PC, Biotin Day Cream to reduce the appearance of age spots and to even the skin tone. Patent-Pending Phase Ingredients INCI Name % w / w Supplier A Lanette O Cetearyl Alcohol PARSOL MCX Ethylhexyl Methoxycinnamate (Octinoxate; USAN) PARSOL 1789 Butyl Methoxydibenzoylmethane (Avobenzone; USAN) PARSOL 340 Octocrylene (Octocrilene; USAN) Myritol 318 Caprylic/Capric Triglyceride Mixed Tocopherols 95 Tocopherol Phenonip Phenoxyethanol & Methylparaben & Ethylparaben & Butylparaben & Propylparaben & Isobutylparaben AMPHISOL K Potassium Cetyl Phosphate Cetiol SB-45 Butyrospermum Parkii (Shea Butter) Finsolv TN C12-15 Alkyl Benzoate Dow Corning 245 Fluid Cyclopentasiloxane Cosmedia SP Sodium Polyacrylate Tegin G 1100 Glycol Distearate PARSOL EHS Ethylhexyl Salicylate (Octisalate; USAN) B Dequest 2046 Pentasodium Ethylenediamine Tetramethylene Phosphonate Water dem. Aqua C Niacinamide PC Niacinamide STAY-C 50 Sodium Ascorbyl Phosphate d-biotin Biotin Water dem. Aqua D Phytantriol Phytantriol E Potassium Hydroxide 30% sol. Potassium Hydroxide Procedure 1 Heat part A to 80 C while stirring. 3 Heat part B to 80 C and add to part A while stirring and homogenizing the emulsion. 4 add part C and D at C under agitation and homogenize the emulsion again 5 adjust the ph to 7.0 or higher with part 5 Technical Data ph: 7.2 Viscosity: cps (Brookfield, RV6, 10 rpm) Supplier DSM Nutritional Products Solutia Inc CLARIANT GMBH Cognis Deutschland GmbH&Co.KG Dow Corning Corporation Evonik Goldschmidt GmbH Finetex, Inc /001 This information is based on our current knowledge and experience and is provided without representation or warranty. Use of this information shall be at your discretion and risk. Nothing herein relieves you from carrying out your own suitability determinations and tests. We disclaim any and all liability in connection with your product or its use. This information does not relieve you of your obligation to comply with all applicable laws and regulations and to observe all third party rights. DSM Nutritional Products, CH-4002 Basel, Switzerland

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67 HYDRAFRESH CREAM GEL AS40004 Formula A LANOL 99 (Isononyl isononanoate-seppic) SEPINOV EMT 10 (Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer - SEPPIC B SOLAGUM AX (Acacia senegal gum and xanthan gum SEPPIC) C D E F AQUAXYL Xylitylglucoside and Anhydroxylitol and Xylitol -SEPPIC Manufacturing Procedure (pilot VMC4 Versamix Rotor Stator 6kg) Comments SEPINOV EMT 10 AQUAXYL AQUACONCEPT: in vitro in vivo SEPPIC SA SEPPIC Inc SEPPIC UK Ltd SEPPIC Italia Srl SEPPIC Asia Singapore SEPPIC BRASIL SEPPIC China SEPPIC GmbH

68 SOLAGUM AX Characteristics Notes AS40004 SEPPIC 0929A All information contained herein is intended merely to demonstrate the utility of SEPPIC products, and should not be construed as granting license to practice any compositions or methods covered by a patent or a patent application. All information contained in this specific technical documentation is believed to be accurate and has been set up by SEPPIC according to its own described methods and processes. SEPPIC however does not assume any liability or risks involved in the use of its products for the preparation and the assessment of the hereinabove formulation since the condition of use are beyond its control. SEPPIC customer must insure that the duplication of the hereinabove formulation is not infringing any intellectual property rights and that it complies with any regulatory status. SEPPIC SA SEPPIC Inc SEPPIC UK Ltd SEPPIC Italia Srl SEPPIC Asia Singapore SEPPIC BRASIL SEPPIC China SEPPIC GmbH

69

70

71 α

72

73

74 λ

75

76

77

78

79

80

81

82

83

84

85

86

87

88 λ

89

90

91

92

93

94

95 Method Melt phase A at 70 C Heat at 70 C water Phase B could be dispersed into water or divided into 2 parts: 1 part in water, 1 part at the end of the process Disperse phase A in water under homomixer Cool down at 40 C whilst stirring Add to emulsion C,D,E and F if necessary and/or part of B

96

97

98 10.00 Sinerga to , Sinerga 5.00 Sinerga 0.3 Method Melt phase A at 70 C Add phase B in phase A Dissolve phase C and heat at 70 C Disperse phase D into phase C. Mix phase A+B into phase C under homomixer Cool down at 40 C whilst stirring Add D,E and F to emulsion

99

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