Recent advances on metastasis suppressor related genes of lung cancer

19 5 2007 10 Chinese Bulletin of Life Sciences Vol. 19, No. 5 Oct., 2007 1004-0374(2007)05-0486-06 ( 610041) nm23 KAI1 TIMP Cadherin MRP-1 A Recent advances on metastasis suppressor related genes of lung cancer FENG Zhihua, ZHU Wen* (State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China) Abstract: Lung cancer is one of the most malignant cancers threatening human health and life. It is also the most rapid increasing cancer both in mobidity and mortality. Invasion and metastasis of lung cancer is the primary cause of patient death. Researches show that genes of nm23, KAI1, TIMP, Cadherin, MRP-1 have played a major role in metastasis suppressing of lung cancer. In this review, we summarized the recent research progresses on the functions of these genes and their relations with invasion and metastasis of lung cancer. Key words: lung cancer metastasis suppressor; gene [1] [1] 1 nm23 nm23 (NCI)Steeg [2] 1988 K-173.5 nm23 nm23 9 (nm23-h1 nm23-h9) nm23-h1 [3] 17q21 22 8.5kb 5 4 2007-06-152007-08-01 (30571837) (0040205505051) (1977 ) (1967 ) * E-mail zwjulia@163.com

5 487 533 nm23-h1 152 17 000 (NDPK) NDPK (1) GTP-GDP (2) GTP G [4] nm23 nm23 Melanie [5] nm23 Ras (KSR) nm23-h1 KSR 392 KSR nm23-h1 Ras- ERK-MAPK Steeg [6] nm23-h1 nm23-h1 96 120 Zhou [7] 96 120 nm23-h1 nm23-h1 NDPK nm23-h1 Che [8] L9981 nm23-h1 β-catenin Ecadherin TIMP-1 MMP-2 CD44V6 VEGF L9981 [9] nm23-h1 nm23-h1 nm23-h1 nm23-h1 [10] [11] nm23-h1 L9981 6 L9981 17 13 2 nm23-h1 nm23-h1 [12] Southern 52 (NSCLC) nm23-h1 nm23-h1 26.92 % (42.85 %) (8.33 %) nm23-h1 NSCLC nm23-h1 [13] nm23 Seifert [14] PCR nm23-h4 H6 H7 2 KAI1 KAI1 CD82() 4 (transmembrane 4 super family, TM4SF) 1995 Dong [15] KAI1 11p11.2 80kb 10 9 267 4 KAI1 KAI1 KAI1 KAI1 [16] Jee [17] KAI1 NSCLC H1299 KAI1 MMP-9 mrna

488 19 TIMP-1 KAI1 TIMP-1 MMP-9 H1299 KAI1 KAI1 4 (tetraspanin web) ( α3 β1 α4β1 α5β1 α6β1 αlβ2) EGFR KAI1 α6β1 EGFR EGFR KAI1 EGFR [18-19] EGFR KAI1 Iiizumi [20] KAI1-DARC( Duffy antigen receptor for chemokines) KAI1 KAI1 + KAI1 DARC KAI1 [21] [22] 240 KAI1 KAI1 25.9% (100%) KAI1 3 TIMP (tisue inhibitors of metalloproteinase, TIMP) (MMP) TIMP-1 2 3 4 Xp11.3 Xp11.23 17q25 22q12.1 q13.2 3p25 TIMP N C MMP MMP MMP (extracellular matrix, ECM) TIMP 1:1 MMP ECM MMP TIMP MMP [23] TIMP-1 TIMP-2 MMP TIMP MMP Bond [24] TIMP-3 MMP TIMP-3 N Caspase-8-9 Fas II TIMP MMP Zhao [25] TIMP-2 MMP-2 MMP-2 TIMP [26] RT-PCR TIMP-1 3 MMP-2 9 138 NSCLC TIMP MMP TIMP MMP NSCLC TNM TIMP MMP TIMP MMP TIMP Neovastat Marimastat MMI-166 Primomastat Fujino [27] MMI-166 MMP-2 ( )MMP-9 MMI-166 6 d Liu [28] Primomastat TIMP Marimastat SCLC [29]

5 489 4 cadherin (E-cadherin) (N-cadherin) (P-cadherin) catenin( ) E-cadherin 16q22.1 16 700 120 000 I E-cadherin E-cadherin [30] E-cadherin Catenin [30] Catenin (a b g) E-cadherin E-cadherin b-catenine-cadherin [31] Witta [32] E-cadherin EGFR EGFRE-cadherin Kashima [33] N-cadherin E-cadherin [34] Bremnes [35] 193 I III NSCLC E-cadherin a b g-catenin 10% 17% 8% 31% E-cadherin NSCLC NSCLC 5 MRP-1 MRP-1(motility related protein-1) Miyake [36] M31 4 12p13.3 20kb 8 227 MRP-1 Funakoshi [37] 30 MRP-1 NSCLC MRP-1 SCLC MRP-1 SCLC OS3-R5 Boyden (videomicroscopic cell motility assay) MRP-1 GFP MRP-1 SCLC MRP-1 MRP-1 β1 MRP-1 MRP-1 Takeda [38] MRP-1 Lewis MRP-1 cdna MRP-1 cdna [39] 54 10 MRP-1 42.6% NSCLC SCLC Funakoshi [37] MRP-1 6

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