Vol. 36, pp , Stage I, II. Stage I, II cm

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1 267 Vol. 36, pp , 2008 : Stage I, II 1 2 Stage I, II cm 6 4cm 69

2 268 1 Breast Cancer 2008; 15: 3-4 4cm CT, MRI

3 269 CT, MRI 4 MR CT MRI MRI MRI MRI MR micro coil 0.1 mm MR 8 9 MR 3 MR micro coil MR MR MR RI ,427 20, RI RI 3 RI RI RI 71

4 270 4 MR 5 Breast Cancer 2008;15: RI RI

5 271 6 down staging 1 13 National Surgical Adjuvant Breast and Bowel Project NSABP B-18 AC 7 NSABP B-18 J Natl Cancer Inst Monogr 2001; 30: AC AC 1 14 EROTC CEF 15 73

6 272 2 NSABP B-18 AC AC EROTC NSABP B-18 AC AC NSABP B-27 T AC AC AC AC T AC 3 8 AC AC T pcr NSABP B-18 pcr pcr NSABP B-27 AC AC T pcr pcr AC AC NSBP B-18 J Nat 1 Cancer Inst Monogr 2001; 30: AC AC NSABP B-27 J Clin Oncol 2003; 21: AC AC T ccr, pcr NSABP B-27 J Clin Oncol 2003; 21:

7 MR 9 10 MR 5 vanishing, scar, concentrated, mosaic, branching 11 pcr Vanishing 100 concentrated 6.9 mosaic 0 mosaic

8 MR 4 branching 47.1 mosaic branching 53.9, Branching mosaic MR 12 76

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10 MR 75 1 Fisher B, Redmond C, Poisson R, Margolese R, Wolmark N, Wickerham L, Fisher E, Deutsch M, Caplan R, Pich Y, et al: Eight-year results of a randomized clinical trial comparing total mastectomy and lumpectomy with or without irradiation in the treatment of breast cancer. N Engl J Med 1989; 320: Veronesi U, Salvadori B, Luini A, Greco M, Saccozzi R, del Vecchio M et al: Breast conservation is a safe method in patients with small cancer of breast. Long-term results of three randomised trials on 1973 patients. Eur J Cancer 1995; 31A: Fisher B, Anderson S, Bryant J, Margolese G, Deutsch M, Fisher ER, et al: Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med 2002; 347: Sonoo H, Noguchi S; Academic Committee of the Japanese Breast Cancer Society: Results of questionnaire survey on breast cancer surgery in Japan Breast Cancer 2008; 15: : 1999; 6 7: Quadrantectomy 54; 2000: Kanemaki Y, Kurihara Y, Itoh D, Kamijo K, Nakajima Y, Fukuda M, Van Cauteren M: MR mammary ductography using a microscopy coil for assessment of intraductal lesions. AJR 2004; 182: Kanemaki Y, Kurihara Y, Okamoto K, Nakajima Y, Fukuda M, Maeda I, Akiyama F: Ductal carcinoma in situ: correlations between high-resolution magnetic resonance imaging and histopathology. Radiat Med 2007; 25: Sonoo H, Fukuda M: The Japanese Breast Cancer Society: Results of questionnaires concerning breast cancer surgery in Japan Breast Cancer 2005; 12: Morrow M, Rademaker AW, Bethke KP, Talamonti MS, Dawes LG, Clauson J, Hansen N. : Learning sentinel node biopsy: results of a prospective randomized trial of two techniques. Surgery 1999; 126: Cody HS 3rd, Fey J, Akhurst T, Fazzari M, Mazumdar M, Yeung H, Yeh SD, Borgen PI: Complementarity of blue dye and isotope in sentinel node localization for breast cancer: univariate and multivariate analysis of 966 procedures. Ann Surg Oncol 2001; 8:

11 Early Breast Cancer Trialists[ Collaborative Group: Polychemotherapy for early breast cancer: an overview of the randomised trials. Lancet 1998; 352: Wolmark N, Wang J, Mamounas E, et al: Preoperative chemotherapy in patients with operable breast cancer: nine-year results from National Surgical Adjuvant Breast and Bowel Project B-18. J Natl Cancer Inst Monogr 2001; 30: van der Hage JA, van de Velde CJ, Julien JP, Tubuliana-Hulin M, Vandervelden C, Duchateau L: Preoperative chemotherapy in primary operable breast cancer: results from the European Organization for Research and Treatment of Cancer trial J Clin Oncol 2001; 19: Bear HD, Anderson S, Brown A, SMIth R, Mamounas EP, Fisher R, Margolese R, Theoret M, Soran A, et al; The e#ect on tumor response of adding sequential preoperative docetaxel to preoperative doxorubicin and cyclophosphamide: preliminary results from National Surgical Adjuvant Breast and Bowel Project Protocol B-27. J Clin Oncol 2003; 21: : : : 2005; 60: : High resolution MRI mammography 2005; 22: