2017 10 42 20 Vol. 42No. 20 October2017 PCOS 1 2 1* 1 1. 210046 2. 213003 CC+ Gn CC PCOS 2015 10 1 2017 4 23 PCOS 60 A CC + Gn + HCG B CC + Gn + Gn LUFS OHSS A B Gn B P < 0. 05 1 LUFS OHSS CC PCOS CC + Gn + DOI:10.19540/j.cnki.cjcmm.20170901.012 Effect of clomiphene citrate and Dingkun Dan on ovulation induction and clinical pregnancy of polycystic ovary syndrome CHEN Lan 1 2 TAN Yong 1* CHEN Shu-ping 1 1. Nanjing University of Traditional Chinese MedicineNanjing 210046China 2. Changzhou Hospital Traditional Chinese MedicineChangzhou 213003China AbstractThe evaluation is based on clomiphene citrate CC+ gonadotropin Gn clinical study on CC and Dingkun Dan' s treatment on ovulation induction and clinical pregnancy effect of PCOSand to provide ideas and methods for traditional Chinese medicine assisted reproductive treatment. This study selected 60 PCOS infertility patients treated with ovulation induction in reproductive medicine clinicjiangsu Province Hospital of traditional Chinese medicine during 2015-10-01 2017-04-23. They were randomly divided into two groupsgroup A CC + Gn + HCGand Group B CC + Gn + Dingkun Dan. These results were observed and compared including cycle ovulation ratecycle cancellation ratecycle pregnancy ratecumulative pregnancy rateendometrial thickness duration of Gntotal amount of Gnthe occurring rate of luteinized unruptured follicle syndrome and ovarian hyperstimulation syndrome. Group A had lower cycle ovulation ratecycle pregnancy ratecumulative pregnancy rate and endometrial thicknesscompared with Group B the difference was statistically significantp < 0. 05. HoweverGroup A had higher cycle cancellation rateduration of Gn and total amount of Gncompared with Group B the difference was statistically significantp < 0. 05. In this studyno case of LUFS or OHSS was found in all patients. CC and Dingkun Dan had the effect of promoting ovulation on PCOS infertility patientsand CC + Gn + Dingkun Dan could elevate clinical pregnancy rate. Key wordsdingkun Danpolycystic ovary syndromeclomiphene citrate 2017-06-02 2017005 * E-mailxijun1025@ 163. com E-mailchenguazhen@ 126. com 4035
2017 10 42 20 Vol. 42No. 20 October2017 polycystic ovary syndrome PCOS / 50 ~ 100 mg 1 5 d polycystic ovaries PCO Gn human menopausal gonadotropin HMG insulin resistance IR 1 PCOS H10940097 75 IU / 2-3 H20052130 75 IU / 75 IU 1 PCOS 9 B 1 1. 1 PCOS 2003 ES- 5 000 ~ 1 U 1 HRE /ASRM PCOS PCOS B CC + Gn + CC Gn A 4 1 2 / 3 PCO 12 2 ~ 9 mm / > 10 ml 0. 5 Z14020656 10. 8 3 2 g / 1 2 8 7 d 9 B 12 16 ~ 18 mm 1. 2 1 PCOS 1 B 2 3 32 B BBT 4 Abbott H20130110 10 mg /40 mg d - 1 5 6 14 d β-hcg HCG 35 d B 1. 3 1 PCOS 1. 6 Gn 2 B Gn lute- unruptured follicle syndrome LUFS 3inized 4 ovarian hyperstimulation syndrome 5 OHSS 6 2 ~ 4 10 mm 1. 7 1 HCG 7 1. 4 2015 10 1 2017 4 23 3 B PCOS 60 1. 8 SPSS 21. 0 x 珋 ± s 1. 5 A clomiphene citrate CC+ gonadotropin human chorionic gonadotropin H20140688 50 mg / 16 ~ 18 mm HCG H44020668 5 000 U / β-hcg B 2 B Gn+ HCG LSD P < 0. 05 P < 0. 01 2 ~ 5 CC 4036
2 PCOS 2. 1 B A B 2 30 2 Gn B 1 1 Table 1 General comparison / / / A 80 30. 13 ± 0. 75 1. 60 ± 0. 16 B 71 28. 63 ± 0. 73 1. 47 ± 0. 15 A B 30 2 3 2. 2 A P < 0. 05 LUFS OHSS2 2. 3 B A A P < 0. 05 3 2. 4 2 2 Table 2 Comparison of ovulation promoting effect Gn Gn /mm /U A 76. 25 23. 75 7. 50 20. 00 6. 98 ± 0. 15 8. 33 ± 0. 32 624. 59 ± 23. 83 B 92. 96 2 7. 04 2 19. 72 1 46. 67 1 10. 13 ± 0. 23 3. 24 ± 0. 22 243. 18 ± 16. 20 A 1 P < 0. 05 2 P < 0. 013 3 Table 3 Comparison of clinical efficacy % A 7. 50 68. 75 23. 75 B 19. 72 1 73. 24 7. 04 2 CC Ding N 15 3 CC PCOS CC PCOS Elbohoty A E 16 5 CC PCOS Gn 17 Birch Petersen K HCG 6 CC 5 PCOS PCOS 15% ~ 40% PCOS Gn PCOS CC 7 CC Hassan A 18 body mass index BMI Gn CC PCOS total testosterone TT anti Gn OHSS mullerian hormone AMH Salaheldin AbdelHamid A M 19 7-8 CC Gn Xi W 9 AMH 10 B CC + Gn + PCOS CC A CC + Gn + HCG P < 0. 01 AMH 7. 77 mg L - 1 92% 65% Vaiarelli A 11 AMH HCG B Gn CC A P < 0. 01 CC + / 12 Paulson M 13 CC Foroozanfard F 14 PCOS 12 Gn + PCOS 4037
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