Vol. 30, pp.239 244, 2002 MRFS Multiple Risk Factor Syndrome 1 2 2 1 1 1 14 8 20 MRFS Multiple Risk Factor Syndrome 30 59 41.9 ± 6.8 14,509 Difficulty in initiating sleep: DISDifficulty in maintaining sleep: DMSMRFS chi-square test Cochran-Armitage chi-square test DMS DMS 1.26, 1.06 1.511.26, 1.04 1.53 DMS DIS MRFS DMS 1 3 1 23.1% 14.1% 2 21 21 1 2 3 4 5 6 3 7 8 9 MRFS Multiple Risk Factor Syndrome 10~12 Sleep apnea syndrome: SAS 13~15 SAS MRFS SAS MRFS 17
Table 1 Sleep Disorder and MRFS Components 16 MRFS 3 SAS MRFS 1998 30 59 41.9 ± 6.8 14,509 Difficulty in initiating sleep: DIS Difficulty in maintaining sleep: DMS 3 4 MRFS MRFS body mass index 25 kg/m 2 110 mg/dl 140 mmhg 90 mmhg 220 mg/dl 150 mg/dl chi-square test Cochran-Armitage SAS system Ver.8.02, SAS Institute Japan 17 5% 14,509 747 5.15% DIS 391 2.69% DMS 519 3.58% chi-square test Table 1 p=0.010 DMS p=0.006p=0.004 DIS DIS p=0.044 Table 2 stepwise 1.22 95%CI 1.05 1.41 DMS 1.26 1.04 1.53 1.26 1.06 1.51 DIS 0.78 0.61 1.00 DIS 18
MRFS Table 2 Age Adjusted Odds Ratio of MRFS Components in Sleep Disorder by Stepwise Multivariate Logistic Model Table 3 Trend between Sleep Disorders and Number of MRFS Components Table 3 Cochran- Armitage DMS p<0.001 p=0.015 DIS p=0.133 MRFS DMS DMS DIS 8 β-blocker 18 Peppard 19 10 42% SAS 20 SAS DMS 21 DMS 8 DMS Young 15 SAS 2 22 8 healthy worker's effect 23 SAS 19
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Abstract Sleep Disorder and MRFS (Multiple Risk Factor Syndrome) in Japanese Male Workers Hirohito Kawaguchi 1, Hiroki Sugimori 2, Machi Suka 2, Ayano Kiyota 1, Toshiaki Suzuki 1, and Toshio Nakamura 1 PURPOSE: We conducted a cross-sectional study to elucidate the relationship between MRFS and sleep disorder. SUBJECT AND METHOD: The present study included 14509 Japanese male workers, aged 30 50 years, who did not have history of cardiovascular disease in the regular health check-ups in 1998. We collected information about the sleep disorder (difficulty in initiating sleep: DIS or difficulty in maintaining sleep: DMS) from the questionnaire. We analyzed the relationship between sleep disorder and components of MRFS: obesity (body mass index 25 kg/m 2 ), impaired glucose tolerance (first plasma glucose 110 mg/dl or the initiation of antidiabetic therapy), hypertension (systolic blood pressure 140 mmhg and/or diastolic blood pressure 90 mmhg, or the initiation of antihypertensive therapy), hyperlipemia (total cholesterol 220 mg/dl or triglyceride 150 mg/dl or the initiation of antilipemic therapy). Moreover, we adjusted the age influence using stepwise multivariate logistic model analysis. Trend between sleep disorder and number of MRFS components was evaluated with the Cochran- Armitage test. RESULTS: A significant relationship was recognized with DMS in hypertension (p=0.006) and hyperlipemia (p=0.004). In DMS, hyperlipemia (Odds ratio 1.26: 95%CI 1.06 1.51) and hypertension (1.26: 1.04 1.53) were significantly incorporated into the multivariate logistic model. The number of workers who had DMS increased with the number of MRFS components (p<0.001). Adjusting age, the number of component did not show any significant relationship with DIS. CONCLUSION: DMS showed close relationships with MRFS. Our results indicate the possibility that a specific higher activity of metabolic status might cause sleep disorders. (St. Marianna Med. J., 30: 239 244, 2002) 1 Division of General Internal Medicine, Department of Internal Medicine 2 Department of Preventive Medicine St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki 216-8511, Japan 22