2015 28 1 R749. 3 B doi 10. 11886 /j. issn. 1007-3256. 2015. 01. 031 1% 1 2 TMS 3 rtms rtms 4 10 Repetitive Transcranial Magnetic Stimulation rtms Deep Transcranial Magnetic 4-5 rtms Stimulation DTMS H H - coil - C C - core Coil Circular 1 Crown Coil 11 H 1. 1 Transcranial Magnetic TMS 8 Stimulation TMS Faraday 1. 5 ~ 2. 5cm 1896 D'Arsonvals DTMS H 3cm 12 110V 30A 42Hz 6cm 11 DTMS 4 1902 Adrian Pollacsek 6 1. 3 TMS TMS 1. 3. 1 Motor Threshold MT TMS rtms 13 TMS 1985 Baker 7-8 TMS 9 1. 2 TMS TMS MEP MT MEP TMS 80% ~ 120% MT MT 50μV 9 MEP TMS MT 84 SYS201261 215008 E - mail xiangdong - du@ 163. com TMS 5
2015 28 1 http / /www. psychjm. net. cn 1. 3. 2 Sachdev 22 rtms 15Hz 90% MT 4 1Hz 4 1Hz 14 2 TMS So- TMS cial Occupational Functioning Assessment Scale SO- FAS 31% 3. 1. 2 rtms 13 TMS Randomized TMS Control Trial RCT rtms 0. 3 ~ DA 1. 0Hz DA PFC> 1. 0Hz 14 rt- 15-17 1 rtms Klein 23 1999 9 18 Rollnik 24 3 rtms BPRS 48. 9 ± 10. 2 33. 3 ± rtms 6. 4 P = 0. 002 42. 4 ± 14. 0 40. 4 ± 9. 6 P = 0. 57 18 3. 1 rtms 4 3. 1. 1 rtms P > 0. 05 Hajak 14 Feinsod 19 rtms 10 P = 0. 03 7 2004 rtms rtms 10Hz 80% MT 5 / DLPFC 14 25-40 DLPFC 41-42 RCT Jandl 21 rtms 10Hz 10 33 > 1Hz 5 Scales for the Assessment of negative symptoms 20Hz 49. 0 ± 10. 7 rtms 26 32-38 44. 7 ± 11. 8 P < 0. 001 33. 3% rtms MS Cohen 20 6 39 rtms rtms 85
2015 28 1 10Hz 110% MT rtms 4 5 20% 62. 5% 33. 3% α 21 EEG 26 43 TMS Rabany 44 45 DTMS 28 4 ~ 6 25 19 rtms RCT 1 rtms RCT Klein 23 1999 35 1Hz 110% MT PFC 10 = Rollnik 24 2000 12 20Hz80% MT PFC 10 BPRS > Hajak 14 2004 20 10Hz110% MT DLPFC 10 > Holi 25 2004 22 10Hz110% MT DLPFC 10 = Yi Jin 43 2006 27 3Hz80% MT 10 Or 20Hz MADRS > Novak 26 2006 16 20Hz90% MT DLPFC 10 = Goyal 27 2007 10 10Hz110% MT DLPFC 10 > Mogg 28 2007 17 10Hz110% MT DLPFC 10 = Prikryl 29 2007 22 10Hz110% MT DLPFC 15 > Fitzgerald 41 2008 20 10Hz110% MT DLPFC 15 = 2008 25 10Hz110% MT DLPFC 20 ANT = 2008 25 10Hz110% MT DLPFC 20 > Schneider 32 2008 51 1Hz110% MT = DLPFC 20 10Hz110% MT > 2009 42 10Hz90% MT DLPFC 20 > HAMD = Cordes 34 2009 70 10Hz110% MT DLPFC 15 > Cordes 35 2010 35 10Hz110% MT DLPFC 10 > 2010 30 TBS 80% MT DLPFC 20 > 2011 46 itbs DLPFC 20 > 2011 23 20Hz80% MT DLPFC 10 > Barr 38 2012 31 20Hz90% MT DLPFC 10 = Guse 39 2012 25 10Hz110% MT DLPFC 15 = Prikryl 40 2013 86 10Hz110% MT DLPFC 15 > MT motor threshold DLPFC indicates dorsolateral prefrontal cortexpositive and negative syndrome scale BPRS Brief Psychiatric Rating Scale MADRS Montgomery - Asbeg Depression Rating Scale Scale for Assessment negative syndromes ANT Attention Net - work Test WSCT Wisconsin Card Test HAMD Hamilton Depression Scale itbs intermittent Theta Burst Stimulation 86
2015 28 1 http / /www. psychjm. net. cn 4 rtms 7321187-193. et al. Repetitive transcranial magnetic stimulation for the treatment of negative symptoms in residual schizophrenia rationale and design of a sham - controlledran-. Eur Arch Psychiatry Clin Neuros- 4. 1 3Cordes JFalkai P Guse B 46 domized multicenter studyj ci2009259 Suppl 2 S189 - S197. 4. 2 rtms rtms negative and positive symptoms in schizophreniaj 47 rtms Res 2009 108 1-3 11-24. 5 M RCT 22 2011 6. 741 magnetischen FeldeJ. Klinische Wochenzeitschrift 108-109. 17 7 4 7Baker AT Jalinous R 4 2 2 of the human motor cortex J. Lancet 1985 1 23 RCT 8Baker AT Freeston IL Jalinous R 5 rtms and the results of an initial clinical evaluationj 1987 20 1 100-109. Mulle 48 1815 Meta rtms 1. 82% ~30. 19% 0. 96% ~ 11. 32% phr Bull 2006 32 2 214-219. 1. 02% ~ 2. 42% 10Stanford AD Sharif Z Corcoran C study and treatment of schizophrenia a review J 0. 11% ~ 0. 46% 3 psychopharmacol 2008 11 4 563-576. rtms Bae 47 rtms comprehensive review J. Eur Psychiatry 2013 26 280 12Rabany L Deutsch L rtms 9. 6% 4 chopharmacol 2014 28 7 686-690. 1. 4% rtms 13Minichino ABersani FSCapra Eet al. ECT rtms 5 2007 25. 2 Insel TR. Rethinking schizophrenia J. Nature2010468 4Freitas CFregni FPascual - Leone A. Meta - analysis of the effects of repetitive transcranial magnetic stimulation rtms on. Schizophr.. 6Beer B. ber das Auftretten einer objectiven Lichtempfindung in 1902 15 Freeston IL. Non - invasive magnetic stimulation 1 84371106-1107. et al. Magnetic stimulation of the human brain and peripheral nervous system an introduction. Neurosurgery 9Kirkpatrick BFenton WSCarpenter WT Jret al. The NIMH - MATRICS consensus statement on negative symptomsj. Schizo- et al. The relationship between dorsolateral prefrontal neuronal N - acetylaspartate and evoked release of striatal dopamine in schizophreniaj. Neuropsychophar- rtms 34 7 1157-1163. rtms rtms Ann N Y Acad Sci 2003 1003 138-158. 16Bertolino ABreier ACallicott JH rtms macology 2000 22 2 125-132. RCT et al. rtms strategies for the. Int J Neuro- 11Bersani FSMinichino AEnticott PGet al. Deep transcranial magnetic stimulation as a treatment for psychiatric disorders A 28 1 30-39. Levkovitz Y. Double - blindrandomized sham controlled study of deep - TMS add - on treatment for negative symptoms and cognitive deficits in schizophreniaj. J Psy- rtmsand deep TMS in pharmacoresistant drug - free patients with unipolar depression a comparative reviewj. Neuropsychiatr Dis Treat 2012 8 55-64. 14Hajak GMarienhagen JLangguth Bet al. High - frequency repetitive transcranial magnetic stimulation in schizophrenia a combined treatment and neuroimaging studyj. Psychol Med 2004 15Laruelle MKegeles LSAbi - Dargham A. Glutamatedopamineand schizophrenia from pathophysiology to treatment J. 17Meyer - Lindenberg AMiletich RSKohn PDet al. Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia J. Nat Neurosci 2002 5 3 267-271. 18Prikryl RKucerova HP. Can repetitive transcranial magnetic stimulation be considered effective treatment option for negative symptoms of schizophrenia J. J ECT 2013 29 1 67-74. 1. M. 19Feinsod MKreanin BChistyakov Aet al. Preliminary evidence 87
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