The Roles of Astrocyte in Nervous System Diseases

BIOTECHNOLOGY BULLETIN 2010 6 650224 The Roles of Astrocyte in Nervous System Diseases Wang Lei Faculty of Life Science and Technology Kunming University of Science and Technology Kunming 650224 Abstract Activated astrocyte can produce and release neurotransmitters neurotrophic factors and cytokines which could involve in pathogenesis of nervous system diseases such as Alzheimer's disease Parkinson's disease epilepsy ischemia Astrocyte may have a protective effect or a toxic effect on neuron and then take part in the pathogenesis of nervous system diseases This review dealed with studies in recent years of the role of astrocyte in nervous system diseases and research prospects were proposed. Key words Astrocyte Alzheimer's disease Parkinson's disease Epilepsy Ischemia astrocyte AS β- amyloidβ-protein Aβ Aβ SP AD Aβ Aβ 1 Aβ 2 3 TNF-α 1-1 IL-1 IL-1 Alzheimer's disease AD senile plaque SP AD 3 Aβ Aβ NFTs 4 Aβ SP AD 2010-01-25 KKSA200826047 KKZ2200826090 E-mail leiwang513@ gmail com

34 Biotechnology Bulletin 2010 6 Aβ AS BDNF Aβ SP NFTs PD 10 11 NOS inos 12 I β- AD E Apo E MAO 13 Apo E Apo E AD Apo Eε4 MPTP MPP + 1- -4-5 6 MPP + MPTP MPP + B MAOB GDNF BDNF ATP iptakalim AD Aβ PCR ELISA MPP + Aβ BDNF BDNF 14 Aβ 7 PD AD PD AD AD 3 AD epilepsy 2 Parkinson s disease PD paralysis agitans Na + /K + PD dopamine DA γ- γ-aminobutyric acid GA- Iewy BA PD DA PD 15 THPO GABA 8 9 GABA

2010 6 35 GABA 16 GABA GABA 19 4 21 22 NGF NGF IL-6 IL-6 IL-6 23 24 bfgf γ- GA- GABA BA 5- bfgf 25 K + bfgf TGF-β 18 26 5 GFAP heat shock protein HSP GFAP Fluorocitrate FC Apo E Apo E FC 0 8 20 nmol 125 nl EEG nerve growth factor NGF interleukin IL gap junction 17 basic fibroblast growth factor bfgf β transforming growth factor β TGF-β brain-derived neurotrophic factor BDNF E apo E

36 Biotechnology Bulletin 2010 6 6 11 Wu X Chen PS Dallas S dopaminergic neurons. Int J Neuropsychopharmacol 1123-1134. 12 3 253-259. 13 Heales SJ Lam AA Duncan AJ 3 513-519. 14 Yang YJ Zhang S Ding JH 1 Kato S Gondo T Hoshü Y et al. Confocal observation of senile relationship between senile plaques and astrocytes. Pathol Int 1998 48 5 332-340. 2 Schubert P Ogata T Miyazaki H et al. Pathological immunoreactions of glial cells in Alzheimer s disease and possible sites of interference. J Neural Transm Suppl 1998 54 167-174. 3 Schubert P Rudolphi K. Interfering with the pathologic activation of microglial cells and astocytes in dementia. Alzheimer Dis Assoc Disord 1998 2 821-828. 4 Johnstone M Gearing AJ Miller KM et al. A central role for tokine and reactive oxygen species are producted. J Neuroimmunl 1999 3 1-2 182-193. 5 Yuling S Shan W Guojun B et al. Glial fibrillary acidic proteinapolipoprotein E apoe transgenic mice astrocyte-specific expression and differing biological effects of astrocyte-secreted apoe3 and apoe4 lipoproteins J Neurosci 1998 18 3261-3272. 6 Ning Z Gayathri R Karl HW. Apolipoprotein E4 domain interaction induces endoplasmic reticulum stress and impairs astrocyte function. J Biol Chem 2009 284 27273-27280. 7 Kimura N Takahashi M Tashiro T et al. Amyloid beta up-regulates brain-derived neurotrophic factor production from astrocytes rescue from amyloid beta-related neuritic degeneration. J Neurosci Res 2006 84 4 782-789. 8 Rothstein JD Dykes HM Pardo CA. Knockout of glutamate transporters reveals a majior role for astroglia transport in excitotoxicity and clearance of glutamate. Neuron 1996 16 3 675-686. 9 Teismann P Schulz JB. Cellular pathology of Parkinson's disease astrocytes microglia and inflammation. Cell Tissue Res 2004 318 1 149-161. 10 Chen PS S PengG Li G et al. Valproate protects dopaminergic neurons in midbrain neuron / glia cultures by stimulating the release of neurotrophic factors from astrocytes. Mol Psychiatry 2006 11 12 1116-1125. et al. Histone deacetylase inhibitors upregulate astrocyte GDNF and BDNF gene transcription and protect 2008 11 8. MN9D. 2007 59 et al. Neurodegeneration or neuroprotection the pivotal role of astrocytes. Neurochem Res 2004 29 et al. Iptakalim protects against MPP + -induced degeneration of dopaminergic neurons in association with astrocyte activation. Int J Neuropsychopharmacol 2009 12 3 317-327. 15 Kimelberg HK Norenberg MD. Astrocytes. Scientific American 1989 260 4 66-72 74 76. 16 Takahashi M Billups B Rossi D et al. The role of glutamate transporters in glutamate homeostasis in the brain. J Exp Biol 1997 200 401-409. 17 Willoughby JO Mackenzie L Broberg M et al Fluorocitrate-mediated astroglial dysfunction causes seizures. Journal of Neuroscience Research 2003 74 160-166. 18 Liu D Smith CL Barone FC et al. Astrocytic demise precedes delayed neuronal death in focal ischemic rat brain. Brain Res Mol Brain Res 1999 68 29-41. 19 Horsburgh K Graham DI Stewart J et al. Influence of apolipoprotein E genotype on neuronal damage and apo E immunoreactivity in brian hippocampus folloeling global ischemia. J Neuropathol Exp Neurol 1999 58 227-234. 20 Loddick SA Turnbull AV Rothwell NJ. Cerebral interleukin-6 is nearopretective during permanent focal cerebral ischemia in the rat. J Cereb Blood Flow Metab 1998 18 176-179. 21 Archana T Peter JB Donna J et al. Astrocyte-derived neurotrophic factor is an ischemia-inducible secreted endoplasmic reticulum stress response protein in the heart. Circ Res 2008 103 1249-1258. 22 Chu LF Wang WT Ghanta VK et al. Ischemic brain cell-derived conditioned medium protects astrocytes against ischemia through GDNF /ERK /NF-kB signaling pathway. Brain Res 2008 1239 24-35. 23 Maeda Y Matsumoto M Hori O et al. Hypoxia / reoxygenation-mediated induction of astrocyte interleukin 6 a paracrine mechanism potentially enhancing neuron survival. J Exp Med 1994 180 2297-2308. 51

2010 6 51 1994 6 440-446 15 Shigetou N Shosuke K Setsuo I et al Detection and differentiation of plant-pathogenic mycoplasmalike organisms using polymerase chain reaction Phytopathology 1993 83 786-791 16 Schneider B Ahrens U Classification of plant-pathgenic mycoplasma-like organism using restriction-site analysis of PCR-amplified 16S rdna Journal of General Microbiology 1993 139 519-527 17 Kuske CR Kirkpatrick BC Davis MJ et al DNA hybridization between western aster yellows mycopolasma-like organism plasmids and extrachromosomal DNA from other plant pathogenic mycaplasma-like organism Molecular Plant-Microbe Interactions 1991 4 75-80 18 International committee on systematic bacteriology subcommittee on the taxonomy of molecules Minutes of the interim meetings 1 and 2 August 1992 Ames Iowa International Journal of Systematic Bacteriology 1993 43 394-397 19 The IRPCM Phytoplasma /Spiroplasma Working Team-Phytoplasma taxonomy group Candidatus Phytoplasma a taxon for the wallless non-helical prokaryotes that colonize plant phloem and insects International Journal of Systematic and Evolutional Microbiology 2004 54 4 1243-1255 20 International Committee on Systematics of Prokaryotes Subcommittee on the Taxonomy of Mollicutes Minutes of the meeting 8 9 and 14 July 2006 Cambridge UK International Journal of Systematic and Evolutional Microbiology 2007 57 1 192-196 21 Zhao Y Davis RE Lee IM Phylogenetic positions of Candidatus Phytoplasma asteris and Spiroplasma kunkelii as inferred from multiple sets of concatenated core housekeeping proteins International Journal of Systematic and Evolutional Microbiology 2005 55 5 2131-2141 22 Lee I M Bottner KD Secor G et al Candidatus Phytoplasma americanum a phytoplasma associated with a potato purple top wilt disease complex International Journal of Systematic and Evolutional Microbiology 2006 56 7 1593-1597 23 2008 35 2 291-295 櫧櫧櫧櫧櫧櫧櫧櫧櫧櫧櫧櫧櫧櫧櫧櫧櫧櫧櫧櫧櫧櫧櫧櫧櫧櫧櫧櫧櫧櫧櫧櫧櫧櫧櫧櫧櫧櫧櫧櫧櫧櫧櫧櫧櫧櫧 36 24. J Pharmacol 1997 327 1 11-16.. 2008 37 3 65-66. 25 Ren JM Finklestein SP. Time windows of infarct reduction by intraveaous basic fibroblast growth factors in focal cerebral ischemia. Eur 26 Fuller JA Brun-Zinkernagel AM Wordinger RJ. PACE4 is involved in TGF-β2 maturation in porcine optic nerve astrocytes. Invest Ophthalmol Vis Sci 2008 49 3685-3692.