Supplementary Online Content

Supplementary Online Content Chang K, Taggart MW, Reyes-Uribe L, et al. Immune profiling of premalignant lesions in patients with Lynch syndrome. JAMA Oncol. Published online April 16, 2018. doi:10.1001/jamaoncol.2018.1482 etable 1. Clinical characteristics of FAP and patients etable 2. Pathology characteristics of FAP and polyps etable 3. Immune profile of polyps compared to FAP etable 4. Immune profile of FAP polyps polyps, and carcinomas etable 5. Gene set enrichment analysis of FAP and polyps, tumor etable 6. Mutational rate analysis in FAP, and hypermutated polyps, and and hypermutated Stage I-II TCGA CRC using RNAseq data etable 7. Immune profile of polyps classified by mutational rate (hyper- versus nonhypermutant) etable 8. Predicted Class I and II HLA genotype of FAP and normal mucosa samples etable 9. List of Predicted neoantigens etable 10. Pathways analysis of MHC I and II neoantigens etable 11. Germline and somatic mutation detected in FAP and polyps. Mutational data derived from RNA-seq analysis efigure 1. Immune profile of Lynch syndrome premalignancy and carcinomas efigure 2. Correlation of DNA and RNA mutation rate in samples from TCGA efigure 3. Mutation Spectrum of FAP and polyps efigure 4. Immunohistochemical staining of CD4 and FOXP3 efigure 5. MHC Class I and II neoantigens in Lynch syndrome and FAP premalignancy, and carcinomas ematerials and Methods ereferences

This supplementary material has been provided by the authors to give readers additional information about their work.

etable 1. Clinical characteristics of FAP and patients Patient ID Gender Age Race Col ore ctal Sx No. of polyp s detect ed Cancer Dx Germline mutation Gene gdna Protein No. of normal mucosa sequen ced No. of adenom as sequen ced FAP_1 M 35 W IRA >100 APC c.1880dupa p.ala630* 1 2 0 FAP_2 M 33 W IRA <5 APC c.3810t>a p.cys1270* 1 2 0 FAP_3 F 42 W IRA 5 APC del exon 14 p.? 1 2 0 FAP_4 M 42 W P >100 HCC, APC c.622c>t p.gln208* 1 3 0 D FAP_5 F 40 W IRA 5 APC del exons 8-9 p.? 1 1 0 FAP_6 M 37 W IRA <5 APC c.1658g>a p.trp553* 1 1 0 FAP_7 M 65 W IRA <50 APC c.477c>g p.tyr159* 1 1 0 FAP_8 F 25 AA NP >100 D APC c.4733_4734del p.cys1578tyrf 1 2 0 s*12 FAP_9 F 28 W IRA >100 EC, APC c.847c>t p.arg283* 1 1 0 OC FAP_10 F 25 W P >100 APC c.3810t>a p.cys1270* 1 1 0 _1 M 53 W RH 1 CC MSH6 c.3744_3773del3 p.his1248_ser 1 1 0 0 1257del _2 F 46 W NP 3 EC MSH2 c.687dela p.ala230leufs* 1 1 0 16 _3 M 52 W LH 1 CC PMS2 del exon 14 p.? 1 1 0 _4 F 37 W NP 1 MSH2 c.1034g>a p.trp345* 1 1 0 _5 F 53 W NP 1 MSH2 c.1661+1g>a p.? 1 1 0 _6 M 58 W NP 2 MSH2 del exons 1-6 p.? 1 1 0 _7 M 76 W LH 2 CC MSH2 c.1216c>t p.arg406* 1 1 0 _8 F 68 W NP 4 EC MSH6 c.3238_3239delc p.leu1080valfs 2 1 0 T *12 _9 F 62 W NP 1 EC MSH6 c.3860ins4 p.p1289x 1 1 0 _10 F 43 W RH 3 CC MSH6 c.2645_2653delt TAAGTCTA p.phe882* 1 1 0 No. of tumors sequen ced

_11 F 63 W TC 3 CC, EC MSH6 c.3699_3702dela p.lys1233asnf 1 1 0 R GAA s*6 _12 F 35 W SC 0 CC MLH1 c.1279c>t p.gln427* 1 0 1 _13 F 76 W SC 0 CC, MLH1 1 0 1 BC, GIST c.1918c>t p.pro640ser _14 F 61 W RH 0 CC PMS2 c.2059c>t p.arg687trp 1 0 1 Abbreviations: M, male; F, Female; W, white; AA, African-American; IRA, ileorectal anastomosis; P, pouch; RH, right hemicolectomy; LH, left hemicolectomy; TCR, transverse colon resection; SC, subtotal colectomy; NP, not performed; NA, not available; CC, colon cancer; HCC, hepatocellular carcinoma; HepBI, hepatoblastoma; D, desmoid; EC, endometrial cancer; OC, ovarian cancer. *Denotes Hispanic ancestry.

etable 2. Pathology characteristics of FAP and polyps Patient ID Sample ID Disease Pathology Location Size/TNM IHC-MSH2 IHC-MSH6 IHC-MLH1 IHC-PMS2 FAP_1 FAP_G2 FAP TA R 5-10 NA NA NA NA FAP_1 FAP_G3 FAP TA R 5-10 NA NA NA NA FAP_2 FAP_G53 FAP TA R <5 NA NA NA NA FAP_2 FAP_G55 FAP TA R <5 NA NA NA NA FAP_3 FAP_G5 FAP TA R <5 NA NA NA NA FAP_3 FAP_G6 FAP TA R <5 NA NA NA NA FAP_4 FAP_G13 FAP TA R 5-10 NA NA NA NA FAP_4 FAP_G14 FAP TA R 5-10 NA NA NA NA FAP_4 FAP_G15 FAP TA R 5-10 NA NA NA NA FAP_5 FAP_G25 FAP TA R <5 NA NA NA NA FAP_6 FAP_G29 FAP TA R NA NA NA NA NA FAP_7 FAP_G39 FAP TA R <5 NA NA NA NA FAP_8 FAP_G47 FAP TA R <5 NA NA NA NA FAP_8 FAP_G48 FAP TA R <5 NA NA NA NA FAP_9 FAP_G67 FAP TA R 5-10 NA NA NA NA FAP_10 FAP_G61 FAP TA NA NA NA NA NA NA _1 _EBL1 TA D 5-10 Intact Intact NA NA _2 _EBL3 TA A <5 Intact Intact NA NA _3 _EBL5 HP D 5-10 NA NA Intact Intact _4 _EBL7 TA with HGD D >10 Lost Lost NA NA _5 _EBL9 TA R 5-10 Lost Lost NA NA _6 _EBL11 TA A >10 Lost Lost NA NA _7 _EBL13 TA A 5-10 Intact Intact NA NA _8 _EBL18 HP D 5-10 Intact Intact NA NA _9 _EBL26 TA D 5-10 NA Intact NA NA _10 _EBL20 TA D 5-10 Intact Lost NA NA _11 _EBL23 TA A <5 Intact Intact NA NA _12 _T3 CA D pt3n0 Intact Intact Lost Lost _13 _T2 CA D pt4an0 Intact Intact Lost Lost _14 _T1 CA A pt2n0 Intact Intact Intact Lost Abbreviations: TA, tubular adenoma; HP, hyperplastic polyp; HGD, high grade dysplasia; A, cecum/ascending/hepatic flexure; D, transverse/descending/sigmoid; R, rectum/rectosigmoid; NA, not assessed. Assessment of expression of MMR proteins in polyps was based on the already known germline mutations.therefore, only the protein pair matching the germline mutation was performed.

etable 3. Immune profile of polyps compared to FAP Gene Mean FAP Mean t test FDR t test P value CD4 45.9874 25.3987 0.0015 0.0002 IFNG 0.1597 0.0483 0.0014 0.0001 TBX21 0.8563 0.6690 0.2707 0.0902 CD8A 9.1375 6.7203 0.3497 0.1813 GZMB 1.4093 1.1421 0.4101 0.2430 PRF1 4.2415 2.9592 0.0237 0.0070 IL21 0.0482 0.0307 0.5886 0.3924 CTLA4 1.3825 1.7024 0.6779 0.5188 PDCD1 1.1953 0.9679 0.4101 0.2356 LAG3 2.8509 1.3900 0.0001 0.0000 CD274 3.5577 2.4652 0.0191 0.0050 IL17A 0.0821 0.1481 0.6779 0.5160 RORC 41.5334 49.5505 0.3011 0.1186 IL23A 0.6413 0.5203 0.7392 0.6023 FOXP3 1.7133 1.2396 0.3160 0.1405 IL10 2.7205 2.6852 0.9142 0.8465 TGFB1 15.6416 13.5568 0.3497 0.1770 PTGS2 3.4271 3.3329 0.9608 0.9608 IL1B 4.9144 8.3386 0.7934 0.7053 IL18 61.2560 53.7937 0.7403 0.6306 IL6 0.2909 0.1470 0.3011 0.1227 IL12A 0.5554 0.2966 0.0015 0.0002 TNF 2.7957 1.4689 0.0109 0.0020 IDO1 8.9288 9.0646 0.9608 0.9570 NOS2 20.7018 17.6395 0.4282 0.2696 HIF1A 110.5035 100.6122 0.6779 0.5273 Genes linked to the immune microenvironment of CRC and MMR deficiency were grouped by lineage and/or function (Th1/Tc1, CTL, Th17, Treg, proinflammation, and metabolism) as previously reported by Llosa et al, Cancer Discovery (2016). Expression values are counts per million. The statistical tests were performed on log2-transformed CPM. Welch's t-test and multiple correction by Benjamini & Hochberg were used (FDR<0.05). Significantly different genes are in bold

etable 4. Immune profile of FAP polyps polyps, and carcinomas Gene Mean Tumor Mean Mean FAP Tumor vs FDR vs FAP FDR Tumor vs FAP FDR CD4 30.9748 45.9874 25.3987 0.3335 0.0471 0.8489 IFNG 0.6023 0.1597 0.0483 0.0000 0.0733 0.0000 TBX21 1.3767 0.8563 0.6690 0.1753 0.9991 0.0340 CD8A 18.3933 9.1375 6.7203 0.0198 0.9991 0.0024 GZMB 15.7904 1.4093 1.1421 0.0000 0.9991 0.0000 PRF1 20.3994 4.2415 2.9592 0.0000 0.9991 0.0000 IL21 0.0395 0.0482 0.0307 0.9207 0.9991 0.9132 IL17A 0.4575 0.0821 0.1481 0.0095 0.9991 0.0256 RORC 2.2877 41.5334 49.5505 0.0003 0.8842 0.0000 IL23A 0.9280 0.6413 0.5203 0.5635 0.9991 0.2871 FOXP3 4.6952 1.7133 1.2396 0.0111 0.9991 0.0023 IL10 0.9193 2.7205 2.6852 0.0012 0.9991 0.0010 TGFB1 31.5878 15.6416 13.5568 0.0003 0.9991 0.0001 PTGS2 24.6403 3.4271 3.3329 0.0001 0.9991 0.0001 IL1B 83.1729 4.9144 8.3386 0.0000 0.9991 0.0000 IL18 5.9157 61.2560 53.7937 0.0108 0.9991 0.0226 IL6 11.3027 0.2909 0.1470 0.0000 0.9991 0.0000 IL12A 0.4365 0.5554 0.2966 0.7072 0.0733 0.6126 TNF 0.6861 2.7957 1.4689 0.0198 0.0710 0.5714 CTLA4 5.4882 1.3825 1.7024 0.0003 0.9991 0.0006 PDCD1 1.5828 1.1953 0.9679 0.5627 0.9991 0.1939 LAG3 5.7383 2.8509 1.3900 0.0001 0.0051 0.0000 CD274 11.9252 3.5577 2.4652 0.0003 0.9991 0.0000 IDO1 17.7229 8.9288 9.0646 0.0118 0.9991 0.0107 NOS2 85.6532 20.7018 17.6395 0.0003 0.9991 0.0001 HIF1A 230.4215 110.5035 100.6122 0.0003 0.9991 0.0001 Genes linked to the immune microenvironment of CRC and MMR deficiency were grouped by lineage and/or function (Th1/Tc1, CTL, Th17, Treg, proinflammation, and metabolism) as previously reported by Llosa et al, Cancer Discovery (2016). Expression values are expressed in counts per million. The statistical tests were performed on log2-transformed CPM. Significance between each groups is tested using ANOVA and Tukey s Test, and Benjamini & Hochberg is used for multiple correction (FDR<0.05). Significantly different genes are in bold.

etable 5. Gene set enrichment analysis of FAP and polyps, tumor Pathways FAP vs FDR FAP vs Tumor FDR vs Tumor FDR Number of genes Reference IMMUNE_ESTIMATE 0.0402 0.4524 0.9942 141 PMID_24113773 IMMUNE_RESP_GO_BP 0.0402 0.9980 0.9942 235 GO_BP IMMUNE_TH1_GALON 0.1113 0.0843 0.9942 8 PMID_17008531_2130397 6 IMMUNE_TH17_GOUNARI 0.6927 0.9980 0.9942 27 PMID_24574339 IMMUNE_TREG_LUCAS 0.8493 0.9980 0.9942 18 PMID_19224638 PD1_REACTOME 0.0007 0.0843 0.9942 18 REACTOME T-cell-signature 0.0003 0.0028 0.9942 13 PMID_27837020 Significance between each groups is tested using ANOVA and Tukey s Test, and Benjamini & Hochberg is used for multiple correction (FDR<0.05). Significantly different genes are in bold. etable 6. Mutational rate analysis in FAP, and hypermutated polyps, and and hypermutated Stage I-II TCGA CRC using RNAseq data Sample ID Type of Sample Mutations/Mb _EBL1 21.755 _EBL13 15.591 _EBL18 7.847 _EBL23 7.68 _EBL26 9.727 _EBL3 12.81 _EBL5 9.647 _EBL7 12.539 _EBL11 Hyper 33.2 _EBL20 Hyper 23.693 _EBL9 Hyper 51.627 _T1 Tumor 21.4 _T2 Tumor 26.4 _T3 Tumor 51.5 FAP_G13 FAP 16.165

FAP_G14 FAP 13.67 FAP_G15 FAP 14.628 FAP_G2 FAP 13.673 FAP_G25 FAP 19.071 FAP_G29 FAP 17.095 FAP_G3 FAP 13.545 FAP_G39 FAP 12.346 FAP_G47 FAP 12.785 FAP_G48 FAP 14.194 FAP_G5 FAP 13.514 FAP_G53 FAP 15.093 FAP_G55 FAP 12.861 FAP_G6 FAP 11.914 FAP_G61 FAP 13.669 FAP_G67 FAP 14.297 TCGA-AA-3517 CRC Stage I,II 8.104 TCGA-AA-3524 CRC Stage I,II 35.901 TCGA-AA-3526 CRC Stage I,II 51.05 TCGA-AA-3527 CRC Stage I,II 35.745 TCGA-AA-3530 CRC Stage I,II 11.371 TCGA-AA-3531 CRC Stage I,II 20.134 TCGA-AA-3532 CRC Stage I,II 9.471 TCGA-AA-3534 CRC Stage I,II 11.247 TCGA-AA-3538 CRC Stage I,II 19.819 TCGA-AA-3544 CRC Stage I,II 21.561 TCGA-AA-3549 CRC Stage I,II 11.601 TCGA-AA-3556 CRC Stage I,II 20.595 TCGA-AA-3561 CRC Stage I,II 10.977 TCGA-AA-3664 CRC Stage I,II 13.049 TCGA-AA-3667 CRC Stage I,II 12.238 TCGA-AA-3673 CRC Stage I,II 5.056 TCGA-AA-3685 CRC Stage I,II 32.866 TCGA-AA-3812 CRC Stage I,II 12.683 TCGA-AA-3814 CRC Stage I,II 7.712 TCGA-AA-3818 CRC Stage I,II 6.398

TCGA-AA-3831 CRC Stage I,II 27.347 TCGA-AA-3837 CRC Stage I,II 3.925 TCGA-AA-3850 CRC Stage I,II 14.124 TCGA-AA-3852 CRC Stage I,II 5.49 TCGA-AA-3854 CRC Stage I,II 5.101 TCGA-AA-3856 CRC Stage I,II 5.247 TCGA-AA-3858 CRC Stage I,II 3.363 TCGA-AA-3866 CRC Stage I,II 7.902 TCGA-AA-3875 CRC Stage I,II 6.472 TCGA-AA-3939 CRC Stage I,II 28.623 TCGA-AA-3956 CRC Stage I,II 39.676 TCGA-AA-3975 CRC Stage I,II 7.482 TCGA-AA-3980 CRC Stage I,II 13.489 TCGA-AA-A004 CRC Stage I,II 12.708 TCGA-AA-A00Z CRC Stage I,II 5.55 TCGA-AA-A017 CRC Stage I,II 14.824 TCGA-AA-A024 CRC Stage I,II 15.46 TCGA-AA-A029 CRC Stage I,II 9.344 TCGA-AA-A02W CRC Stage I,II 12.006 TCGA-AA-A02Y CRC Stage I,II 40.213 TCGA-AY-4071 CRC Stage I,II 3.937 TCGA-AA-3710 CRC Stage I,II Hyper 30.885 TCGA-AA-3715 CRC Stage I,II Hyper 21.551 TCGA-AA-3864 CRC Stage I,II Hyper 34.182 TCGA-AA-3877 CRC Stage I,II Hyper 27.482 TCGA-AA-A00N CRC Stage I,II Hyper 42.666 TCGA-AA-A010 CRC Stage I,II Hyper 59.93

etable 7. Immune profile of polyps classified by mutational rate (hyper- versus non-hypermutant) Gene Hypermutant Mean muta nt Mean Hypervs muta nt FDR Hypervs muta nt p-value CD4 42.268 47.382 0.8453 0.6574 IFNG 0.141 0.167 0.9375 0.8565 TBX21 0.693 0.918 0.7547 0.3808 CD8A 6.919 9.970 0.7547 0.4472 GZMB 1.342 1.435 0.8860 0.7219 PRF1 4.051 4.313 0.9375 0.8613 IL21 0.039 0.052 0.9375 0.9375 IL17A 0.081 0.083 0.9375 0.9242 RORC 37.285 43.126 0.8295 0.5372 IL23A 0.573 0.667 0.9375 0.9101 FOXP3 2.839 1.291 0.0466 0.0017 IL10 1.880 3.036 0.0651 0.0145 TGFB1 18.171 14.693 0.7204 0.2935 PTGS2 5.660 2.590 0.0789 0.0205 IL1B 4.935 4.907 0.8295 0.5530 IL18 33.313 71.735 0.0520 0.0058 IL6 0.446 0.233 0.7547 0.4226 IL12A 0.439 0.599 0.2647 0.0882 TNF 2.024 3.085 0.3795 0.1405 CTLA4 2.281 1.045 0.0495 0.0037 PDCD1 1.283 1.163 0.7547 0.3759 LAG3 2.654 2.925 0.8453 0.6361 CD274 3.039 3.752 0.7547 0.3989 IDO1 10.619 8.295 0.8453 0.6166 NOS2 27.165 18.278 0.1003 0.0297

etable 8. Predicted Class I and II HLA genotype of FAP and normal mucosa samples Patie nt ID FAP_ 1 FAP_ 4 FAP_ 5 FAP_ 6 FAP_ 3 FAP_ 7 FAP_ 8 FAP_ 2 FAP_ 9 FAP_ 10 _5 Sample ID FAP_G 1 FAP_G 16 FAP_G 26 FAP_G 31 FAP_G 4 FAP_G 40 FAP_G 49 FAP_G 54 FAP_G 60 FAP_G 62 _EBL 10 Region A Region B Region C Region DQA Region DQB Region DRB Allele Allele Allele Allele Allele Allele Allele 1 Allele 2 Allele 1 Allele 2 Allele 1 Allele 2 1 2 1 2 1 2 HLA- HLA- HLA- HLA- HLA- HLA- DQA1*01 DQA1*01 DQB1*06 DQB1*05 DRB1*01 DRB1*15 A*01: A*11: B*39: B*52: C*12: C*12: :02 :02 :01 :01 :01 :02 01 01 01 01 02 02 HLA- A*25: 01 HLA- A*29: 02 HLA- A*01: 01 HLA- A*24: 02 HLA- A*29: 02 HLA- A*34: 02 HLA- A*33: 03 HLA- A*24: 02 HLA- A*24: 02 HLA- A*23: 01 HLA- A*11: 01 HLA- A*24: 02 HLA- A*24: 02 HLA- A*02: 01 HLA- A*03: 01 HLA- A*02: 01 HLA- A*03: 01 HLA- A*02: 01 HLA- A*02: 01 HLA- A*01: 01 HLA- B*18: 01 HLA- B*56: 01 HLA- B*15: 17 HLA- B*18: 01 HLA- B*44: 03 HLA- B*45: 01 HLA- B*44: 03 HLA- B*18: 01 HLA- B*15: 07 HLA- B*44: 03 HLA- B*35: 01 HLA- B*51: 01 HLA- B*07: 02 HLA- B*07: 02 HLA- B*07: 02 HLA- B*53: 01 HLA- B*51: 01 HLA- B*44: 02 HLA- B*15: 07 HLA- B*07: 02 HLA- C*04: 01 HLA- C*02: 02 HLA- C*07: 01 HLA- C*05: 01 HLA- C*16: 01 HLA- C*04: 01 HLA- C*15: 02 HLA- C*05: 01 HLA- C*03: 04 HLA- C*04: 01 HLA- C*12: 03 HLA- C*01: 02 HLA- C*07: 01 HLA- C*07: 02 HLA- C*07: 02 HLA- C*16: 01 HLA- C*07: 01 HLA- C*12: 03 HLA- C*03: 04 HLA- C*07: 02 DQA1*01 :04 DQA1*02 :01 DQA1*01 :02 DQA1*03 :02 DQA1*02 :01 DQA1*04 :01 DQA1*01 :02 DQA1*03 :02 DQA1*03 :02 DQA1*05 :01 DQA1*01 :04 DQA1*01 :02 DQA1*01 :02 DQA1*02 :01 DQA1*01 :02 DQA1*01 :02 DQA1*02 :01 DQA1*05 :01 DQA1*01 :02 DQA1*01 :01 DQB1*06 :13 DQB1*05 :01 DQB1*06 :13 DQB1*03 :02 DQB1*06 :02 DQB1*06 :02 DQB1*05 :02 DQB1*03 :01 DQB1*06 :11 DQB1*03 :01 DQB1*05 :01 DQB1*02 :01 DQB1*06 :13 DQB1*02 :01 DQB1*02 :01 DQB1*03 :09 DQB1*02 :05 DQB1*03 :01 DQB1*03 :02 DQB1*05 :01 DRB1*01 :01 DRB1*01 :01 DRB1*13 :02 DRB1*04 :01 DRB1*07 :01 DRB1*15 :03 DRB1*16 :01 DRB1*04 :01 DRB1*04 :04 DRB1*01 :01 DRB1*15 :01 DRB1*07 :01 DRB1*15 :01 DRB1*07 :01 DRB1*15 :01 DRB1*08 :04 DRB1*07 :01 DRB1*11 :04 DRB1*15 :01 DRB1*11 :04

etable 9. List of Predicted Neoantigens Chromosome Position Sample Gene Best.MT.Score Expression Allele MHC (TPM) Frequency 1 14109058 FAP_G13 PRDM2 39.5 15.95 0.195 MHC_I 1 16258928 FAP_G13 SPEN 359.7 10.97 0.196 MHC_I 1 166818356 FAP_G13 POGK 4.4 28.79 0.115 MHC_I 1 180053254 FAP_G13 CEP350 250.6 10.2 0.156 MHC_I 1 185089552 FAP_G13 TRMT1L 218 13.52 0.062 MHC_I 10 105495507 FAP_G13 SH3PXD2A 148.3 26.72 0.075 MHC_I 10 114917781 FAP_G13 TCF7L2 279.5 31.06 0.385 MHC_I 10 115612623 FAP_G13 DCLRE1A 415 10.15 0.176 MHC_I 11 46703602 FAP_G13 ARHGAP1 343.8 50.23 0.081 MHC_I 12 21626520 FAP_G13 RECQL 14.1 16.91 0.096 MHC_I 12 48084336 FAP_G13 RPAP3 20.4 17.27 0.099 MHC_I 12 59281595 FAP_G13 LRIG3 11.1 25.92 0.057 MHC_I 12 109522775 FAP_G13 USP30 98.4 14.55 0.111 MHC_I 13 24411739 FAP_G13 MIPEP 108.6 30.56 0.07 MHC_I 14 24878811 FAP_G13 NYNRIN 4.9 14.77 0.2 MHC_I 14 31637582 FAP_G13 HECTD1 96.9 37.33 0.061 MHC_I 14 31814322 FAP_G13 HEATR5A 247 13.62 0.103 MHC_I 14 90397941 FAP_G13 EFCAB11 470.6 17.84 0.125 MHC_I 15 25620790 FAP_G13 UBE3A 178 33.77 0.058 MHC_I 15 28474843 FAP_G13 HERC2 14.7 12.08 0.3 MHC_I 15 89836004 FAP_G13 FANCI 63.2 18.56 0.056 MHC_I 16 84600531 FAP_G13 COTL1 19.7 62.39 0.062 MHC_I 17 15978875 FAP_G13 NCOR1 77.9 35.98 0.052 MHC_I 17 16052812 FAP_G13 NCOR1 449.7 35.98 0.284 MHC_I 17 73515123 FAP_G13 TSEN54 3.6 28.04 0.105 MHC_I 18 44426713 FAP_G13 PIAS2 232.4 17.68 0.057 MHC_I 2 18736845 FAP_G13 RDH14 231.7 28.11 0.07 MHC_I

2 27601679 FAP_G13 ZNF513 162.9 20.73 0.097 MHC_I 2 88892839 FAP_G13 EIF2AK3 430.9 21.62 0.2 MHC_I 2 203420129 FAP_G13 BMPR2 13.7 11.76 0.125 MHC_I 2 203420129 FAP_G13 BMPR2 13.7 11.76 0.088 MHC_I 2 203420129 FAP_G13 BMPR2 16.2 11.76 0.125 MHC_I 2 203420129 FAP_G13 BMPR2 16.2 11.76 0.088 MHC_I 22 43253147 FAP_G13 ARFGAP3 37.9 41.63 0.136 MHC_I 3 97686274 FAP_G13 MINA 16.1 13.28 0.069 MHC_I 3 193382704 FAP_G13 OPA1 4.4 40.16 0.09 MHC_I 3 194146150 FAP_G13 ATP13A3 9.3 38.68 0.078 MHC_I 4 110454749 FAP_G13 SEC24B 12.1 25.94 0.106 MHC_I 4 169195168 FAP_G13 DDX60 55.4 13.86 0.091 MHC_I 5 6746387 FAP_G13 PAPD7 41.5 14.95 0.167 MHC_I 5 55237518 FAP_G13 IL6ST 110.2 25.11 0.055 MHC_I 5 87501638 FAP_G13 TMEM161B 25.2 18.72 0.133 MHC_I 6 106967244 FAP_G13 AIM1 216.6 42.29 0.078 MHC_I 6 110530369 FAP_G13 CDC40 165.9 23.12 0.13 MHC_I 7 11030370 FAP_G13 PHF14 99.1 25.94 0.145 MHC_I 7 38812211 FAP_G13 VPS41 381.6 27.08 0.091 MHC_I 7 50514060 FAP_G13 FIGNL1 25.3 10.89 0.257 MHC_I 7 89856719 FAP_G13 STEAP2 94.1 12.33 0.25 MHC_I 7 100029007 FAP_G13 MEPCE 205.2 33.76 0.354 MHC_I 8 90993682 FAP_G13 NBN 498.4 32.04 0.07 MHC_I 9 94171750 FAP_G13 NFIL3 378.9 19.71 0.063 MHC_I 1 35790968 FAP_G14 ZMYM4 75.5 17.46 0.185 MHC_I 1 247014141 FAP_G14 AHCTF1 114.9 13.29 0.068 MHC_I 10 53458999 FAP_G14 CSTF2T 139.2 19.72 0.067 MHC_I 10 97916170 FAP_G14 ZNF518A 196.7 17.03 0.152 MHC_I 10 112661364 FAP_G14 BBIP1 137.7 12.76 0.136 MHC_I 10 114911552 FAP_G14 TCF7L2 33.4 34.08 0.174 MHC_I 10 120489818 FAP_G14 CACUL1 6.9 19.81 0.103 MHC_I

11 16892700 FAP_G14 PLEKHA7 419.1 14.5 0.115 MHC_I 11 45935395 FAP_G14 PEX16 155.9 21.15 0.064 MHC_I 11 47376999 FAP_G14 SPI1 68.5 13.97 0.075 MHC_I 11 64597015 FAP_G14 CDC42BPG 144.6 18.07 0.07 MHC_I 11 71148862 FAP_G14 DHCR7 96.1 25.73 0.098 MHC_I 11 111915865 FAP_G14 DLAT 84.9 31.41 0.059 MHC_I 12 57553691 FAP_G14 LRP1 22.9 39.52 0.057 MHC_I 12 57553693 FAP_G14 LRP1 273.7 39.52 0.057 MHC_I 12 117583969 FAP_G14 FBXO21 4.7 27.69 0.054 MHC_I 13 20220724 FAP_G14 MPHOSPH8 173.9 31.7 0.09 MHC_I 14 50933311 FAP_G14 MAP4K5 15.6 22.13 0.093 MHC_I 14 74345900 FAP_G14 PTGR2 82.4 17.5 0.135 MHC_I 15 25584316 FAP_G14 UBE3A 40.5 35.9 0.098 MHC_I 15 30011997 FAP_G14 TJP1 40.9 22.67 0.083 MHC_I 15 34527447 FAP_G14 SLC12A6 168 13.77 0.1 MHC_I 15 82533696 FAP_G14 EFTUD1 477.3 32.27 0.069 MHC_I 16 50134245 FAP_G14 HEATR3 88.1 16.5 0.256 MHC_I 17 36966833 FAP_G14 CWC25 262.1 16.02 0.273 MHC_I 18 9211730 FAP_G14 ANKRD12 28.2 12.4 0.115 MHC_I 2 73996405 FAP_G14 DUSP11 393.4 29.42 0.072 MHC_I 20 44522683 FAP_G14 CTSA 308.3 235.47 0.169 MHC_I 20 47686754 FAP_G14 CSE1L 91.8 44.46 0.08 MHC_I 3 36872574 FAP_G14 TRANK1 143.1 16.57 0.068 MHC_I 3 39135424 FAP_G14 WDR48 50.8 37.22 0.085 MHC_I 3 97686274 FAP_G14 MINA 16.1 15.39 0.091 MHC_I 3 123451781 FAP_G14 MYLK 479.8 37.07 0.15 MHC_I 3 193382704 FAP_G14 OPA1 4.4 36.44 0.105 MHC_I 5 55237518 FAP_G14 IL6ST 110.2 29.05 0.056 MHC_I 5 87521593 FAP_G14 TMEM161B 138.7 18.6 0.114 MHC_I 7 89856719 FAP_G14 STEAP2 94.1 11.82 0.227 MHC_I 7 91503179 FAP_G14 MTERF 21.4 11.64 0.1 MHC_I

8 90993682 FAP_G14 NBN 498.4 27.41 0.063 MHC_I 1 9305562 FAP_G15 H6PD 53 34.89 0.067 MHC_I 1 78187733 FAP_G15 USP33 18.6 41.87 0.051 MHC_I 11 14882799 FAP_G15 PDE3B 120.2 19.52 0.408 MHC_I 11 67934464 FAP_G15 SUV420H1 162.9 36.4 0.085 MHC_I 11 74053618 FAP_G15 PGM2L1 155 13.57 0.095 MHC_I 11 121475905 FAP_G15 SORL1 34.8 68.69 0.129 MHC_I 12 1702238 FAP_G15 FBXL14 360.2 24.29 0.057 MHC_I 12 57135291 FAP_G15 PRIM1 38.8 16.46 0.171 MHC_I 13 31725288 FAP_G15 HSPH1 253 44.27 0.08 MHC_I 14 23598945 FAP_G15 SLC7A8 232.4 53.34 0.055 MHC_I 14 92253887 FAP_G15 TC2N 125.3 53.54 0.065 MHC_I 16 14711479 FAP_G15 PARN 14.1 31.53 0.081 MHC_I 16 18569061 FAP_G15 NOMO2 137.1 50.77 0.2 MHC_I 16 23546280 FAP_G15 EARS2 190.2 19.75 0.525 MHC_I 16 57269044 FAP_G15 RSPRY1 268.9 30.37 0.111 MHC_I 19 12856300 FAP_G15 ASNA1 71 89.15 0.107 MHC_I 19 35174128 FAP_G15 ZNF302 51.8 25.12 0.122 MHC_I 2 11389837 FAP_G15 ROCK2 21.3 63.26 0.143 MHC_I 2 229890569 FAP_G15 PID1 16.5 43.38 0.064 MHC_I 2 230668773 FAP_G15 TRIP12 115.8 49.34 0.513 MHC_I 20 10393366 FAP_G15 MKKS 497.5 35.29 0.052 MHC_I 3 63981867 FAP_G15 ATXN7 39.7 11.12 0.143 MHC_I 3 97686274 FAP_G15 MINA 16.1 15.12 0.088 MHC_I 3 139346515 FAP_G15 NMNAT3 65.9 11.64 0.143 MHC_I 3 145799525 FAP_G15 PLOD2 119.9 48.11 0.081 MHC_I 3 184922464 FAP_G15 EHHADH 6.6 28.73 0.063 MHC_I 4 110454749 FAP_G15 SEC24B 12.1 28.84 0.173 MHC_I 4 153864507 FAP_G15 FHDC1 430.6 17.1 0.409 MHC_I 5 36117881 FAP_G15 LMBRD2 39.8 13.94 0.107 MHC_I 5 52161600 FAP_G15 ITGA1 5.2 12.31 0.222 MHC_I

5 54555685 FAP_G15 DHX29 48.8 20.19 0.081 MHC_I 5 55237518 FAP_G15 IL6ST 110.2 22.74 0.059 MHC_I 5 72858434 FAP_G15 ANKRA2 111 32.07 0.053 MHC_I 6 41877149 FAP_G15 MED20 203.8 21.61 0.068 MHC_I 6 106967244 FAP_G15 AIM1 216.6 47.85 0.091 MHC_I 6 110530369 FAP_G15 CDC40 165.9 24.98 0.159 MHC_I 6 139264691 FAP_G15 REPS1 9.9 26.94 0.125 MHC_I 6 149916207 FAP_G15 KATNA1 109.8 16.21 0.078 MHC_I 7 94164724 FAP_G15 CASD1 345.6 27.21 0.061 MHC_I 7 138210057 FAP_G15 TRIM24 121.4 23.25 0.171 MHC_I 9 18143 FAP_G15 WASH1 10.6 13.99 0.667 MHC_I 9 26886129 FAP_G15 CAAP1 161.3 37.85 0.058 MHC_I 9 140247215 FAP_G15 EXD3 8.3 10.59 0.333 MHC_I X 74293781 FAP_G15 ABCB7 81.7 29.81 0.098 MHC_I X 119005930 FAP_G15 NDUFA1 46.8 630.54 0.261 MHC_I X 129290502 FAP_G15 AIFM1 97.4 67.64 0.052 MHC_I 1 54675779 FAP_G2 MRPL37 79.4 118.46 0.472 MHC_I 1 68948427 FAP_G2 DEPDC1 261.2 10.25 0.258 MHC_I 1 91405165 FAP_G2 ZNF644 328.3 30.02 0.079 MHC_I 1 229601235 FAP_G2 NUP133 361.3 25.53 0.068 MHC_I 1 247014141 FAP_G2 AHCTF1 322.9 12.41 0.077 MHC_I 10 79397185 FAP_G2 KCNMA1 19.5 13.34 0.079 MHC_I 10 86130816 FAP_G2 CCSER2 35.9 15.28 0.143 MHC_I 12 64828647 FAP_G2 XPOT 91.5 35.35 0.055 MHC_I 12 109921682 FAP_G2 UBE3B 23.8 22.01 0.054 MHC_I 13 26956961 FAP_G2 CDK8 248.4 22.23 0.344 MHC_I 14 23420864 FAP_G2 HAUS4 305.8 58.19 0.529 MHC_I 14 36018352 FAP_G2 RALGAPA1 256.6 18.59 0.143 MHC_I 16 4924668 FAP_G2 UBN1 42.2 20.31 0.075 MHC_I 16 22343403 FAP_G2 POLR3E 23.6 22.59 0.088 MHC_I 17 2371076 FAP_G2 METTL16 118.5 10.86 0.24 MHC_I

17 70120292 FAP_G2 SOX9 204 108.13 0.084 MHC_I 2 100020923 FAP_G2 REV1 407.4 21.71 0.053 MHC_I 2 152316604 FAP_G2 RIF1 87.5 11.56 0.25 MHC_I 2 153004779 FAP_G2 STAM2 20.1 19.03 0.065 MHC_I 20 5559030 FAP_G2 GPCPD1 189.6 27.63 0.107 MHC_I 20 36687910 FAP_G2 RPRD1B 50.6 19.47 0.077 MHC_I 3 33626305 FAP_G2 CLASP2 138.9 13.32 0.075 MHC_I 3 33650077 FAP_G2 CLASP2 112 13.32 0.115 MHC_I 3 42602714 FAP_G2 SEC22C 464.7 18.05 0.132 MHC_I 3 81720070 FAP_G2 GBE1 36.3 18.15 0.119 MHC_I 4 22415377 FAP_G2 GPR125 51.6 41.27 0.052 MHC_I 4 107092270 FAP_G2 TBCK 197.3 17.11 0.063 MHC_I 4 129099754 FAP_G2 LARP1B 25.3 21.03 0.385 MHC_I 5 148904673 FAP_G2 CSNK1A1 80.4 146.13 0.51 MHC_I 6 106727570 FAP_G2 ATG5 135.2 34.6 0.071 MHC_I 6 111310240 FAP_G2 RPF2 24.9 45.73 0.115 MHC_I 7 99506230 FAP_G2 TRIM4 207.3 19.96 0.064 MHC_I 7 156589160 FAP_G2 LMBR1 180.4 21.28 0.169 MHC_I X 148582538 FAP_G2 IDS 24.1 28.43 0.223 MHC_I 1 91403063 FAP_G25 ZNF644 133.9 33.2 0.158 MHC_I 12 51385382 FAP_G25 SLC11A2 158.7 15.23 0.136 MHC_I 13 41654831 FAP_G25 WBP4 13.7 10.46 0.121 MHC_I 15 83208738 FAP_G25 RPS17L 265.2 3787.42 0.115 MHC_I 16 67477072 FAP_G25 ATP6V0D1 250.5 89.15 0.093 MHC_I 17 79077889 FAP_G25 BAIAP2 439.8 10.15 0.22 MHC_I 2 65480928 FAP_G25 ACTR2 339 72.64 0.065 MHC_I 2 160628445 FAP_G25 CD302 475.1 14.27 0.122 MHC_I 2 166615346 FAP_G25 GALNT3 62.9 46.85 0.079 MHC_I 3 125725303 FAP_G25 SLC41A3 11.3 16.44 0.063 MHC_I 4 159606334 FAP_G25 ETFDH 406.9 18.36 0.073 MHC_I 6 106696039 FAP_G25 ATG5 401.9 33.66 0.055 MHC_I

1 204197289 FAP_G29 PLEKHA6 340.6 12.38 0.115 MHC_I 10 88197701 FAP_G29 WAPAL 67.1 10.33 0.077 MHC_I 10 95454638 FAP_G29 FRA10AC1 450.8 12.02 0.105 MHC_I 11 93471306 FAP_G29 TAF1D 172.4 31.49 0.109 MHC_I 13 25008997 FAP_G29 PARP4 15 20.17 0.092 MHC_I 14 65381187 FAP_G29 CHURC1 19.4 24.6 0.093 MHC_I 14 92251705 FAP_G29 TC2N 4.8 28.55 0.164 MHC_I 15 44055275 FAP_G29 PDIA3 80.1 395.96 0.061 MHC_I 2 232326652 FAP_G29 NCL 7.5 243.68 0.069 MHC_I 20 54974315 FAP_G29 CSTF1 15.6 17.14 0.108 MHC_I 22 37162188 FAP_G29 IFT27 79 36.29 0.114 MHC_I 22 46098591 FAP_G29 ATXN10 103.7 40.9 0.115 MHC_I 4 103189225 FAP_G29 SLC39A8 38.3 67.39 0.189 MHC_I 5 179046273 FAP_G29 HNRNPH1 417.8 247.53 0.054 MHC_I 8 24249828 FAP_G29 ADAMDEC1 204.9 74.51 0.1 MHC_I 9 131454204 FAP_G29 SET 32.2 191.54 0.053 MHC_I X 101408997 FAP_G29 BEX5 348 14.31 0.062 MHC_I 1 35480655 FAP_G3 ZMYM6 12.7 14.27 0.186 MHC_I 1 43829648 FAP_G3 ELOVL1 343.3 102.59 0.316 MHC_I 1 51048344 FAP_G3 FAF1 50.4 28.76 0.13 MHC_I 1 154523916 FAP_G3 UBE2Q1 24.3 45.07 0.241 MHC_I 11 67934464 FAP_G3 SUV420H1 162.9 31.98 0.074 MHC_I 11 68367959 FAP_G3 PPP6R3 19.8 42.02 0.075 MHC_I 14 36018352 FAP_G3 RALGAPA1 256.6 16.13 0.222 MHC_I 14 92471831 FAP_G3 TRIP11 363.9 11.94 0.12 MHC_I 14 93760617 FAP_G3 BTBD7 107.7 14.94 0.13 MHC_I 15 40854986 FAP_G3 C15orf57 48.4 31.43 0.058 MHC_I 15 64066970 FAP_G3 HERC1 273 10.49 0.176 MHC_I 15 64747205 FAP_G3 TRIP4 331 28.17 0.058 MHC_I 18 21523784 FAP_G3 LAMA3 25.2 12.24 0.514 MHC_I 18 32920554 FAP_G3 ZNF24 409.6 32.46 0.057 MHC_I

19 55559835 FAP_G3 RDH13 67.4 20.65 0.075 MHC_I 3 43641915 FAP_G3 ANO10 19.6 23.31 0.07 MHC_I 3 133666227 FAP_G3 SLCO2A1 65 27.34 0.059 MHC_I 5 139903713 FAP_G3 ANKHD1 28.2 31.09 0.137 MHC_I 5 139903713 FAP_G3 ANKHD1-28.2 14.92 0.137 MHC_I EIF4EBP3 6 170880560 FAP_G3 TBP 54 18.57 0.057 MHC_I 7 92761752 FAP_G3 SAMD9L 357.5 16.73 0.051 MHC_I 8 38123661 FAP_G3 PPAPDC1B 46.8 82.58 0.051 MHC_I 9 86617646 FAP_G3 RMI1 428.9 11.44 0.362 MHC_I X 100630169 FAP_G3 BTK 27.7 15.11 0.13 MHC_I 11 43350325 FAP_G39 API5 450 38.09 0.053 MHC_I 11 65655423 FAP_G39 FIBP 58.2 40.14 0.069 MHC_I 11 95564342 FAP_G39 CEP57 323.7 19.54 0.063 MHC_I 12 29496096 FAP_G39 ERGIC2 25.5 41.83 0.089 MHC_I 14 35050806 FAP_G39 SNX6 90.2 65.27 0.067 MHC_I 16 15091639 FAP_G39 PDXDC1 451.3 81.94 0.085 MHC_I 17 38243083 FAP_G39 THRA 22.6 18.51 0.096 MHC_I 2 136537955 FAP_G39 UBXN4 347.7 56.08 0.071 MHC_I 2 223489444 FAP_G39 FARSB 56.7 39.33 0.094 MHC_I 22 23915577 FAP_G39 IGLL1 11.3 211.7 0.333 MHC_I 3 58302694 FAP_G39 RPP14 56 16.42 0.108 MHC_I 3 193382704 FAP_G39 OPA1 7.7 19.71 0.094 MHC_I 4 24550502 FAP_G39 DHX15 196.4 76.38 0.078 MHC_I 5 14608915 FAP_G39 FAM105A 75.7 19.98 0.077 MHC_I 5 64100142 FAP_G39 CWC27 306.2 19.15 0.125 MHC_I 5 171638950 FAP_G39 UBTD2 38.5 13.4 0.233 MHC_I 6 160196216 FAP_G39 ACAT2 453.7 56.1 0.131 MHC_I X 70516490 FAP_G39 NONO 272.7 89.47 0.067 MHC_I 1 29365810 FAP_G47 EPB41 8.3 20.93 0.067 MHC_I 1 47173603 FAP_G47 EFCAB14 131.1 38.21 0.061 MHC_I 1 85397050 FAP_G47 MCOLN2 40.2 13.43 0.12 MHC_I

1 146672923 FAP_G47 FMO5 51.1 22.88 0.075 MHC_I 1 209961769 FAP_G47 IRF6 375.2 23.88 0.118 MHC_I 10 93021137 FAP_G47 PCGF5 131.2 76.48 0.121 MHC_I 11 58384775 FAP_G47 ZFP91 230.2 33.5 0.104 MHC_I 11 82880952 FAP_G47 PCF11 15.6 19.52 0.178 MHC_I 12 21661479 FAP_G47 GOLT1B 11.8 34.61 0.068 MHC_I 12 44148162 FAP_G47 PUS7L 55.1 14.61 0.075 MHC_I 13 75876414 FAP_G47 TBC1D4 215.9 11.29 0.073 MHC_I 14 55643819 FAP_G47 DLGAP5 137.9 22.26 0.161 MHC_I 14 72128104 FAP_G47 SIPA1L1 20.7 12.29 0.185 MHC_I 15 59406800 FAP_G47 CCNB2 14.5 38.36 0.063 MHC_I 16 58608633 FAP_G47 CNOT1 36 29.13 0.143 MHC_I 16 67477072 FAP_G47 ATP6V0D1 44.1 59.57 0.224 MHC_I 17 29226335 FAP_G47 TEFM 47.1 34.94 0.057 MHC_I 18 260212 FAP_G47 THOC1 53.5 26.78 0.074 MHC_I 18 9570178 FAP_G47 PPP4R1 454.4 19.99 0.102 MHC_I 18 33691076 FAP_G47 SLC39A6 13.4 17.03 0.061 MHC_I 19 6389459 FAP_G47 GTF2F1 336.6 31.11 0.059 MHC_I 2 37487371 FAP_G47 PRKD3 16 13.93 0.091 MHC_I 2 70315174 FAP_G47 PCBP1 422.9 170.51 0.056 MHC_I 2 95787497 FAP_G47 MRPS5 79.3 55.5 0.053 MHC_I 2 159488390 FAP_G47 PKP4 21.5 21.12 0.057 MHC_I 3 88205388 FAP_G47 C3orf38 67.6 26.37 0.052 MHC_I 3 170108207 FAP_G47 SKIL 79.1 32.27 0.055 MHC_I 4 77065549 FAP_G47 NUP54 408.3 48.53 0.056 MHC_I 4 128814503 FAP_G47 PLK4 105.2 12.41 0.086 MHC_I 5 41934329 FAP_G47 FBXO4 190.2 23.58 0.061 MHC_I 5 54645466 FAP_G47 SKIV2L2 15.2 45.99 0.092 MHC_I 5 114860048 FAP_G47 FEM1C 432 17.96 0.063 MHC_I 6 31773903 FAP_G47 M2 3 65.64 0.079 MHC_I 7 156589130 FAP_G47 LMBR1 9.4 16 0.079 MHC_I

1 8422751 FAP_G48 RERE 157.6 16.53 0.129 MHC_I 1 51005336 FAP_G48 FAF1 52.9 14 0.167 MHC_I 1 161133740 FAP_G48 USP21 470.4 11.96 0.188 MHC_I 10 32576151 FAP_G48 EPC1 305.2 19.73 0.055 MHC_I 11 2950399 FAP_G48 PHLDA2 92.4 23.01 0.051 MHC_I 11 58384775 FAP_G48 ZFP91 230.2 32.27 0.139 MHC_I 11 82880952 FAP_G48 PCF11 15.6 17.95 0.2 MHC_I 11 114578178 FAP_G48 NXPE2 202.8 18.1 0.154 MHC_I 12 105589066 FAP_G48 APPL2 51.9 33.1 0.075 MHC_I 12 122825968 FAP_G48 CLIP1 38.4 11.02 0.083 MHC_I 14 31917387 FAP_G48 DTD2 110.7 17.27 0.051 MHC_I 15 35274372 FAP_G48 ZNF770 389.1 17.88 0.087 MHC_I 16 15978045 FAP_G48 FOPNL 441.2 41.95 0.06 MHC_I 16 46695692 FAP_G48 VPS35 64.2 74.72 0.052 MHC_I 16 58608633 FAP_G48 CNOT1 36 27.16 0.077 MHC_I 16 67477072 FAP_G48 ATP6V0D1 44.1 78.5 0.101 MHC_I 16 68267962 FAP_G48 ESRP2 238.2 39.35 0.06 MHC_I 17 67260965 FAP_G48 ABCA5 70.1 15.75 0.055 MHC_I 18 260212 FAP_G48 THOC1 53.5 21.34 0.1 MHC_I 18 59757761 FAP_G48 PIGN 340.8 20.76 0.068 MHC_I 19 4054669 FAP_G48 ZBTB7A 293.1 21.11 0.086 MHC_I 19 33984213 FAP_G48 PEPD 187.2 32.07 0.058 MHC_I 19 55698881 FAP_G48 PTPRH 302.8 26.47 0.068 MHC_I 2 20455795 FAP_G48 PUM2 82.3 40.94 0.062 MHC_I 2 100011002 FAP_G48 EIF5B 295.7 21.04 0.114 MHC_I 7 92861785 FAP_G48 CCDC132 231.2 21.99 0.093 MHC_I 9 95992134 FAP_G48 WNK2 35.6 12.89 0.125 MHC_I 1 21220014 FAP_G5 EIF4G3 10 34.36 0.082 MHC_I 1 35919168 FAP_G5 KIAA0319L 11.3 38.26 0.082 MHC_I 1 52280223 FAP_G5 NRD1 409.3 70.68 0.091 MHC_I 1 154229586 FAP_G5 UBAP2L 92.5 50.77 0.067 MHC_I

1 201983065 FAP_G5 ELF3 422.9 448.41 0.393 MHC_I 10 47919971 FAP_G5 FAM21B 167.9 18.08 0.107 MHC_I 10 75299276 FAP_G5 USP54 6.7 33.91 0.056 MHC_I 10 111883935 FAP_G5 ADD3 10.9 112.6 0.059 MHC_I 11 43465666 FAP_G5 TTC17 302.7 35.65 0.097 MHC_I 11 60670256 FAP_G5 PRPF19 133.9 118.1 0.405 MHC_I 12 50482355 FAP_G5 SMARCD1 163.5 28.35 0.108 MHC_I 12 62798030 FAP_G5 USP15 351.8 19.95 0.155 MHC_I 12 64875701 FAP_G5 TBK1 65 22.57 0.1 MHC_I 12 65141513 FAP_G5 GNS 95.3 53.32 0.115 MHC_I 12 110451041 FAP_G5 ANKRD13A 18.9 25.09 0.11 MHC_I 14 55817786 FAP_G5 FBXO34 138.2 59.19 0.06 MHC_I 15 31233717 FAP_G5 MTMR10 30.9 20.23 0.085 MHC_I 15 41046816 FAP_G5 RMDN3 48.1 40.05 0.06 MHC_I 15 64669047 FAP_G5 KIAA0101 113.3 22.14 0.061 MHC_I 16 72138457 FAP_G5 DHX38 120 32.13 0.129 MHC_I 17 12853004 FAP_G5 ARHGAP44 28.9 27.83 0.405 MHC_I 17 27409385 FAP_G5 MYO18A 361.3 35.03 0.104 MHC_I 17 40870508 FAP_G5 EZH1 44.2 15.82 0.188 MHC_I 18 44416349 FAP_G5 PIAS2 352.8 14.1 0.17 MHC_I 18 72913415 FAP_G5 ZADH2 195 25.12 0.065 MHC_I 19 804596 FAP_G5 PTBP1 13.7 152.43 0.336 MHC_I 19 10257082 FAP_G5 DNMT1 110.9 23.23 0.093 MHC_I 2 11356307 FAP_G5 ROCK2 70.1 64.11 0.107 MHC_I 2 44436421 FAP_G5 PPM1B 400.8 44.53 0.071 MHC_I 2 61441220 FAP_G5 USP34 67 22.81 0.268 MHC_I 2 174228145 FAP_G5 CDCA7 404.3 87.71 0.082 MHC_I 20 9318697 FAP_G5 PLCB4 178.4 74.35 0.053 MHC_I 21 34110493 FAP_G5 PAXBP1 21.8 25.96 0.068 MHC_I 3 38263085 FAP_G5 OXSR1 64.3 32.08 0.111 MHC_I 3 56702472 FAP_G5 FAM208A 60.6 22.72 0.065 MHC_I

3 160134136 FAP_G5 SMC4 471.9 31.42 0.191 MHC_I 3 160148986 FAP_G5 SMC4 214.5 31.42 0.065 MHC_I 3 179094918 FAP_G5 MFN1 395.4 37.85 0.068 MHC_I 4 102117109 FAP_G5 PPP3CA 49.1 37.53 0.053 MHC_I 4 107133947 FAP_G5 TBCK 80.7 16.35 0.116 MHC_I 4 123271209 FAP_G5 KIAA1109 283.6 17.46 0.118 MHC_I 4 159816976 FAP_G5 FNIP2 225.5 20.14 0.063 MHC_I 5 60053357 FAP_G5 ELOVL7 3.5 20.86 0.107 MHC_I 5 68687681 FAP_G5 RAD17 146.1 25.05 0.148 MHC_I 5 134193047 FAP_G5 C5orf24 343.6 25.93 0.068 MHC_I 6 25529084 FAP_G5 LRRC16A 2.9 28.26 0.055 MHC_I 6 52268214 FAP_G5 PAQR8 22.3 88.16 0.284 MHC_I 6 109322505 FAP_G5 SESN1 48.9 32.18 0.061 MHC_I 7 99490177 FAP_G5 TRIM4 398.8 27.64 0.053 MHC_I 9 5811133 FAP_G5 ERMP1 21.1 34.68 0.136 MHC_I X 122755071 FAP_G5 THOC2 320.2 25.47 0.095 MHC_I 1 8422745 FAP_G53 RERE 392.8 28.14 0.085 MHC_I 1 86842011 FAP_G53 ODF2L 339.1 24.54 0.317 MHC_I 1 150131221 FAP_G53 PLEKHO1 162.4 15.06 0.102 MHC_I 1 172538276 FAP_G53 SUCO 333.8 18.09 0.222 MHC_I 1 172579236 FAP_G53 SUCO 68.8 18.09 0.074 MHC_I 1 222802633 FAP_G53 MIA3 455.2 17.34 0.167 MHC_I 10 15255510 FAP_G53 FAM171A1 94.8 27.48 0.065 MHC_I 10 24909895 FAP_G53 ARHGAP21 23.5 23.26 0.093 MHC_I 10 38343543 FAP_G53 ZNF33A 61 25.01 0.064 MHC_I 10 47000081 FAP_G53 GPRIN2 46 24.29 0.16 MHC_I 11 3794866 FAP_G53 NUP98 120.5 16.67 0.167 MHC_I 12 29496096 FAP_G53 ERGIC2 58.5 51.18 0.056 MHC_I 12 30833472 FAP_G53 IPO8 28.8 22.16 0.103 MHC_I 12 57648788 FAP_G53 R3HDM2 266 15.17 0.1 MHC_I 14 45675309 FAP_G53 MIS18BP1 327.5 12.88 0.083 MHC_I

15 25584316 FAP_G53 UBE3A 11.1 31.53 0.076 MHC_I 15 45408409 FAP_G53 DUOXA2 81.9 65.2 0.435 MHC_I 15 59455377 FAP_G53 MYO1E 81.4 27.58 0.053 MHC_I 15 65472500 FAP_G53 CLPX 141.2 33.55 0.056 MHC_I 16 11873075 FAP_G53 ZC3H7A 321.1 18.73 0.094 MHC_I 16 74530385 FAP_G53 GLG1 171.6 21.91 0.105 MHC_I 17 5392612 FAP_G53 MIS12 378.7 16.04 0.058 MHC_I 17 5392614 FAP_G53 MIS12 71.3 16.04 0.056 MHC_I 17 60038270 FAP_G53 MED13 430.3 14.08 0.095 MHC_I 19 50985463 FAP_G53 EMC10 234.3 126.54 0.053 MHC_I 20 34241753 FAP_G53 RBM12 277.6 15.58 0.111 MHC_I 20 43615935 FAP_G53 STK4 212.7 11.71 0.107 MHC_I 22 50898397 FAP_G53 SBF1 137.1 25.18 0.13 MHC_I 3 49053638 FAP_G53 DALRD3 82.1 20.99 0.061 MHC_I 3 58256683 FAP_G53 ABHD6 40.2 22.25 0.154 MHC_I 3 125725917 FAP_G53 SLC41A3 207.3 26.16 0.057 MHC_I 3 127394887 FAP_G53 ABTB1 147.4 26.93 0.067 MHC_I 4 84393409 FAP_G53 FAM175A 377.8 10.76 0.071 MHC_I 6 17765056 FAP_G53 KIF13A 136.3 37.1 0.075 MHC_I 6 42937639 FAP_G53 PEX6 206.2 11.98 0.115 MHC_I 6 74354277 FAP_G53 SLC17A5 22.9 50.68 0.074 MHC_I 6 80878721 FAP_G53 BCKDHB 94.7 37.24 0.068 MHC_I 8 124266478 FAP_G53 ZHX1 435.1 20.2 0.069 MHC_I 1 27621110 FAP_G55 WDTC1 57.1 25.4 0.085 MHC_I 1 86842011 FAP_G55 ODF2L 339.1 27.75 0.2 MHC_I 1 150131221 FAP_G55 PLEKHO1 162.4 16.2 0.091 MHC_I 1 231044470 FAP_G55 TTC13 47.1 20.44 0.096 MHC_I 10 32120676 FAP_G55 ARHGAP12 138.4 33.42 0.083 MHC_I 11 3789861 FAP_G55 NUP98 67.5 18 0.086 MHC_I 12 29496096 FAP_G55 ERGIC2 58.5 46.28 0.065 MHC_I 12 64816983 FAP_G55 XPOT 203 22.7 0.146 MHC_I

12 108941677 FAP_G55 SART3 377.4 14.26 0.143 MHC_I 14 36192335 FAP_G55 RALGAPA1 56.3 15.54 0.107 MHC_I 17 40476850 FAP_G55 STAT3 60.4 50.34 0.081 MHC_I 5 131039787 FAP_G55 FNIP1 81.3 10.33 0.176 MHC_I 5 133295258 FAP_G55 C5orf15 189 60.93 0.06 MHC_I 6 71236179 FAP_G55 FAM135A 239.3 24.08 0.118 MHC_I 6 74354277 FAP_G55 SLC17A5 22.9 58.57 0.086 MHC_I 7 92730738 FAP_G55 SAMD9 42.6 29.33 0.122 MHC_I 7 99490177 FAP_G55 TRIM4 150.3 21.62 0.058 MHC_I 9 95004492 FAP_G55 IARS 292 23.23 0.055 MHC_I 1 11155838 FAP_G6 EXOSC10 61.1 44.48 0.06 MHC_I 1 52280223 FAP_G6 NRD1 409.3 61.38 0.082 MHC_I 1 86842004 FAP_G6 ODF2L 278.1 30.54 0.12 MHC_I 1 119618996 FAP_G6 WARS2 309.5 12.55 0.2 MHC_I 1 145368619 FAP_G6 NBPF10 6.5 12.93 0.113 MHC_I 1 156697209 FAP_G6 ISG20L2 15.8 28.36 0.052 MHC_I 10 70725198 FAP_G6 DDX21 37.1 41.34 0.181 MHC_I 10 75290100 FAP_G6 USP54 12.6 31.75 0.081 MHC_I 11 10875015 FAP_G6 ZBED5 43.2 39.45 0.053 MHC_I 11 43465666 FAP_G6 TTC17 302.7 34.92 0.096 MHC_I 11 64594831 FAP_G6 CDC42BPG 170.8 22.24 0.053 MHC_I 11 70218481 FAP_G6 PPFIA1 382.7 27.18 0.068 MHC_I 12 27472325 FAP_G6 STK38L 313.1 33.16 0.092 MHC_I 12 62798030 FAP_G6 USP15 351.8 19.05 0.156 MHC_I 12 90020290 FAP_G6 ATP2B1 17.3 33.19 0.066 MHC_I 12 110451041 FAP_G6 ANKRD13A 18.9 45.15 0.072 MHC_I 16 11873075 FAP_G6 ZC3H7A 457.4 26.45 0.063 MHC_I 16 15178538 FAP_G6 RRN3 34.4 33.05 0.064 MHC_I 16 22343403 FAP_G6 POLR3E 28 20.02 0.088 MHC_I 16 72138457 FAP_G6 DHX38 120 27.24 0.111 MHC_I 16 75681968 FAP_G6 TERF2IP 414.7 41.8 0.088 MHC_I

17 27409385 FAP_G6 MYO18A 361.3 37.19 0.085 MHC_I 17 79220034 FAP_G6 SLC38A10 33 54.85 0.095 MHC_I 19 19906229 FAP_G6 ZNF506 14.6 16 0.091 MHC_I 19 40392499 FAP_G6 FCGBP 84.6 322.08 0.065 MHC_I 2 11356307 FAP_G6 ROCK2 70.1 52.78 0.068 MHC_I 2 37347209 FAP_G6 EIF2AK2 289.8 18.37 0.055 MHC_I 2 44436421 FAP_G6 PPM1B 400.8 47 0.089 MHC_I 2 88888285 FAP_G6 EIF2AK3 93.1 30.09 0.061 MHC_I 20 2816762 FAP_G6 PCED1A 8.8 20.41 0.075 MHC_I 20 6060206 FAP_G6 FERMT1 7.8 62.98 0.056 MHC_I 3 9876962 FAP_G6 TTLL3 6.4 12.36 0.093 MHC_I 3 25647591 FAP_G6 TOP2B 7.3 59.03 0.127 MHC_I 3 38263085 FAP_G6 OXSR1 64.3 29.16 0.123 MHC_I 3 136287629 FAP_G6 STAG1 6.2 24.43 0.111 MHC_I 3 179094918 FAP_G6 MFN1 395.4 33.22 0.146 MHC_I 4 69816847 FAP_G6 UGT2A3 112.6 66.84 0.055 MHC_I 4 190873406 FAP_G6 FRG1 4.6 50.64 0.057 MHC_I 5 68408981 FAP_G6 SLC30A5 95.2 40.77 0.099 MHC_I 5 127474360 FAP_G6 SLC12A2 10.8 102.38 0.057 MHC_I 7 117292925 FAP_G6 CFTR 75.1 93.9 0.062 MHC_I 7 129813546 FAP_G6 TMEM209 474.6 15.89 0.143 MHC_I 9 5811133 FAP_G6 ERMP1 21.1 35.79 0.088 MHC_I 9 6887960 FAP_G6 KDM4C 88.5 21.83 0.231 MHC_I 9 72933855 FAP_G6 SMC5 441.7 30.06 0.113 MHC_I 9 140099512 FAP_G6 TMEM203 44.4 30.24 0.054 MHC_I X 122755071 FAP_G6 THOC2 320.2 26.38 0.086 MHC_I 1 58999868 FAP_G61 OMA1 5.6 29.73 0.069 MHC_I 1 246518356 FAP_G61 SMYD3 474.4 13.28 0.125 MHC_I 10 27409370 FAP_G61 YME1L1 190.9 84.12 0.113 MHC_I 11 62296734 FAP_G61 AHNAK 78.1 110.1 0.053 MHC_I 11 70218481 FAP_G61 PPFIA1 111 26.85 0.074 MHC_I

11 85977144 FAP_G61 EED 426.8 24.13 0.113 MHC_I 11 96104236 FAP_G61 CCDC82 354.7 15.38 0.068 MHC_I 12 59271483 FAP_G61 LRIG3 354.5 30.65 0.085 MHC_I 12 116421103 FAP_G61 MED13L 183.4 18.33 0.125 MHC_I 13 40233534 FAP_G61 COG6 159.7 19.11 0.133 MHC_I 14 51387267 FAP_G61 PYGL 418.8 23.33 0.071 MHC_I 14 102452081 FAP_G61 DYNC1H1 9.3 45.02 0.077 MHC_I 15 59964846 FAP_G61 BNIP2 1.6 31.38 0.059 MHC_I 17 37682263 FAP_G61 CDK12 188.9 15.9 0.064 MHC_I 17 47679242 FAP_G61 SPOP 129.1 34.42 0.057 MHC_I 17 57153072 FAP_G61 TRIM37 415.8 13.29 0.118 MHC_I 17 63532654 FAP_G61 AXIN2 39 107.77 0.086 MHC_I 19 2076868 FAP_G61 MOB3A 56.8 12.67 0.097 MHC_I 19 4363452 FAP_G61 SH3GL1 163.9 38.04 0.096 MHC_I 19 4694711 FAP_G61 DPP9 229.7 25.26 0.051 MHC_I 19 40411811 FAP_G61 FCGBP 5.8 384.26 0.069 MHC_I 2 242572926 FAP_G61 THAP4 341 88.53 0.051 MHC_I 20 30785453 FAP_G61 PLAGL2 119.8 20.04 0.111 MHC_I 20 33329244 FAP_G61 NCOA6 217.4 16.53 0.058 MHC_I 20 61833730 FAP_G61 YTHDF1 39.6 29.45 0.273 MHC_I 3 44437977 FAP_G61 TCAIM 23.7 22.71 0.313 MHC_I 3 138290147 FAP_G61 CEP70 10.1 19.98 0.068 MHC_I 3 142281435 FAP_G61 ATR 245.6 12.26 0.217 MHC_I 3 145789075 FAP_G61 PLOD2 238.1 42.71 0.08 MHC_I 5 122154534 FAP_G61 SNX2 30.6 67.52 0.081 MHC_I 5 137726897 FAP_G61 KDM3B 46.6 29.83 0.137 MHC_I 6 33264397 FAP_G61 RGL2 16.8 17.06 0.063 MHC_I 6 101127558 FAP_G61 ASCC3 54.2 25.3 0.171 MHC_I 6 109772841 FAP_G61 MICAL1 108.9 37.69 0.085 MHC_I 7 99516985 FAP_G61 TRIM4 219.6 16.45 0.115 MHC_I 7 135261066 FAP_G61 NUP205 127.9 23.64 0.156 MHC_I

7 150778661 FAP_G61 TMUB1 75.9 47.94 0.056 MHC_I 1 41536272 FAP_G67 SCMH1 100.8 16.06 0.095 MHC_I 1 146658499 FAP_G67 FMO5 4.4 16.67 0.073 MHC_I 12 12483767 FAP_G67 MANSC1 483 24.28 0.051 MHC_I 14 51375597 FAP_G67 PYGL 102 13.76 0.141 MHC_I 14 53250203 FAP_G67 GNPNAT1 157.5 38.84 0.167 MHC_I 17 73871103 FAP_G67 TRIM47 8.2 19.2 0.059 MHC_I 2 148712924 FAP_G67 ORC4 64 17.68 0.096 MHC_I 2 198263198 FAP_G67 SF3B1 114.7 99.71 0.438 MHC_I 3 45785155 FAP_G67 SACM1L 493.5 18.87 0.054 MHC_I 3 51993981 FAP_G67 PCBP4 381.3 18.22 0.063 MHC_I 3 69124582 FAP_G67 UBA3 277.6 55.82 0.051 MHC_I 6 110533440 FAP_G67 CDC40 12.1 15.29 0.143 MHC_I 7 129064718 FAP_G67 AHCYL2 31.8 19.08 0.119 MHC_I 9 84249101 FAP_G67 TLE1 220.5 16.53 0.063 MHC_I 9 131585027 FAP_G67 C9orf114 378.9 10.87 0.063 MHC_I X 118716593 FAP_G67 UBE2A 202 49.98 0.784 MHC_I 1 16271286 _EBL1 ZBTB17 190.3 12.83 0.282 MHC_I 10 27009239 _EBL1 PDSS1 156 25.5 0.093 MHC_I 11 67413234 _EBL1 ACY3 50.6 16.32 0.097 MHC_I 15 34659235 _EBL1 LPCAT4 197.2 72.96 0.081 MHC_I 15 35163023 _EBL1 AQR 52.6 11.17 0.114 MHC_I 15 35189805 _EBL1 AQR 136.4 11.17 0.08 MHC_I 15 65885839 _EBL1 VWA9 42.4 41.69 0.053 MHC_I 17 648188 _EBL1 GEMIN4 12.4 13.24 0.073 MHC_I 17 41168352 _EBL1 VAT1 52.5 16.61 0.082 MHC_I 17 42964009 _EBL1 EFTUD2 156.4 30.76 0.061 MHC_I 17 45662948 _EBL1 NPEPPS 122.2 33.65 0.182 MHC_I 17 45662950 _EBL1 NPEPPS 107.2 33.65 0.182 MHC_I 17 46675419 _EBL1 HOXB6 19.8 36.7 0.061 MHC_I 19 19766136 _EBL1 ATP13A1 298.4 18.82 0.067 MHC_I

19 53270614 _EBL1 ZNF600 81.7 21.1 0.1 MHC_I 19 55710106 _EBL1 PTPRH 236.7 14.73 0.071 MHC_I 3 122271386 _EBL1 PARP9 191.7 15.53 0.2 MHC_I 5 41934329 _EBL1 FBXO4 263.7 10.97 0.104 MHC_I 5 175925969 _EBL1 FAF2 16.2 18.13 0.222 MHC_I 6 109308758 _EBL1 SESN1 195.2 41.7 0.052 MHC_I 7 1510770 _EBL1 INTS1 76.1 11.8 0.054 MHC_I 9 84226740 _EBL1 TLE1 365.2 20.69 0.2 MHC_I 9 91965713 _EBL1 SECISBP2 82.8 27.01 0.1 MHC_I 9 100447238 _EBL1 XPA 239.9 17.28 0.097 MHC_I X 2867517 _EBL1 ARSE 108.2 30.81 0.057 MHC_I X 107331187 _EBL1 PSMD10 111.2 56.16 0.052 MHC_I 1 6314643 _EBL11 GPR153 126.5 16.37 0.1 MHC_I 1 16458713 _EBL11 EPHA2 310.6 33.31 0.273 MHC_I 1 22155398 _EBL11 HSPG2 418.3 19.45 0.067 MHC_I 1 29319988 _EBL11 EPB41 8 28.65 0.119 MHC_I 1 35457949 _EBL11 ZMYM6 56.8 11.87 0.067 MHC_I 1 45268740 _EBL11 PLK3 116.7 10.03 0.278 MHC_I 1 60370607 _EBL11 CYP2J2 357.8 46.5 0.062 MHC_I 1 70716406 _EBL11 SRSF11 208.3 114.02 0.325 MHC_I 1 151400320 _EBL11 POGZ 232.5 28.91 0.14 MHC_I 1 153904888 _EBL11 DENND4B 495 15.89 0.098 MHC_I 1 161092043 _EBL11 DEDD 315.8 28.69 0.052 MHC_I 1 161145766 _EBL11 B4GALT3 430.5 29.41 0.208 MHC_I 1 207263776 _EBL11 C4BPB 332.7 18.59 0.269 MHC_I 10 124361540 _EBL11 DMBT1 143 119.07 0.28 MHC_I 11 290067 _EBL11 ATHL1 484.6 106.18 0.063 MHC_I 11 47857271 _EBL11 NUP160 451.6 19.97 0.156 MHC_I 11 66333833 _EBL11 CTSF 61.8 32.31 0.276 MHC_I 11 74081973 _EBL11 PGM2L1 286.6 11.4 0.25 MHC_I 11 86519164 _EBL11 PRSS23 265.8 43.57 0.072 MHC_I

12 6666182 _EBL11 NOP2 390 29.32 0.06 MHC_I 12 115115392 _EBL11 TBX3 456.7 40.7 0.094 MHC_I 13 110838827 _EBL11 COL4A1 220.7 44.58 0.053 MHC_I 14 23608730 _EBL11 SLC7A8 395.4 29.19 0.246 MHC_I 14 24839301 _EBL11 NFATC4 49.5 11.05 0.172 MHC_I 14 88946246 _EBL11 PTPN21 185 13.15 0.121 MHC_I 14 105834860 _EBL11 PACS2 78.2 19.83 0.235 MHC_I 15 75137840 _EBL11 SCAMP2 88.5 165.4 0.236 MHC_I 16 57059431 _EBL11 NLRC5 21 16.72 0.143 MHC_I 16 67318291 _EBL11 PLEKHG4 246.8 43.67 0.076 MHC_I 16 74537509 _EBL11 GLG1 198.6 38.61 0.238 MHC_I 16 90020704 _EBL11 DEF8 62 36.06 0.108 MHC_I 17 27903134 _EBL11 GIT1 141.7 32.92 0.071 MHC_I 17 36061132 _EBL11 HNF1B 90.9 31.11 0.13 MHC_I 17 40266550 _EBL11 KAT2A 377.1 46.15 0.09 MHC_I 17 40457655 _EBL11 STAT5A 337.3 20.12 0.333 MHC_I 17 79653397 _EBL11 HGS 236.4 62.84 0.356 MHC_I 17 80405477 _EBL11 C17orf62 392.9 64.63 0.206 MHC_I 19 10202224 _EBL11 C19orf66 68.5 30.58 0.091 MHC_I 19 17322818 _EBL11 MYO9B 286.8 20.38 0.114 MHC_I 19 18280045 _EBL11 PIK3R2 185.7 38.56 0.167 MHC_I 19 46274305 _EBL11 DMPK 29.2 20.66 0.379 MHC_I 19 47996750 _EBL11 NAPA 102.2 95.31 0.13 MHC_I 19 56113688 _EBL11 ZNF524 51.5 39.64 0.202 MHC_I 2 27600985 _EBL11 ZNF513 24.3 27.65 0.33 MHC_I 2 86992166 _EBL11 RMND5A 153.1 34.79 0.059 MHC_I 2 88472847 _EBL11 THNSL2 451 25.68 0.19 MHC_I 2 103324746 _EBL11 SLC9A2 276.3 38.4 0.261 MHC_I 2 236649677 _EBL11 AGAP1 9.5 10.71 0.258 MHC_I 20 62904741 _EBL11 PCMTD2 354.1 46.09 0.054 MHC_I 22 22142997 _EBL11 MAPK1 470.4 47.06 0.053 MHC_I

22 23524342 _EBL11 BCR 206.8 20.15 0.175 MHC_I 22 24176338 _EBL11 SMARCB1 490.3 72.96 0.051 MHC_I 22 37421079 _EBL11 MPST 308.8 140.14 0.231 MHC_I 22 44893294 _EBL11 LDOC1L 405.9 16.48 0.125 MHC_I 3 9807533 _EBL11 CAMK1 197.4 16.37 0.143 MHC_I 3 98251487 _EBL11 GPR15 48.9 17.47 0.162 MHC_I 3 127398960 _EBL11 ABTB1 194.7 52.2 0.289 MHC_I 3 186504995 _EBL11 EIF4A2 145 420.31 0.07 MHC_I 4 1991480 _EBL11 NELFA 407.9 31.3 0.115 MHC_I 4 56233791 _EBL11 SRD5A3 291.7 21.99 0.257 MHC_I 4 115597107 _EBL11 UGT8 43.5 46.33 0.406 MHC_I 4 159158777 _EBL11 TMEM144 53.2 22.7 0.151 MHC_I 5 141248235 _EBL11 PCDH1 32.3 43.57 0.085 MHC_I 5 154181850 _EBL11 LARP1 42.7 47.98 0.17 MHC_I 6 4128047 _EBL11 ECI2 423.6 100.98 0.201 MHC_I 6 27114400 _EBL11 HIST1H2BK 426 76.51 0.051 MHC_I 6 30888131 _EBL11 VARS2 96.3 19.22 0.375 MHC_I 6 112397206 _EBL11 TUBE1 155.1 12.52 0.172 MHC_I 6 126210494 _EBL11 NCOA7 410.1 87.75 0.538 MHC_I 7 98592387 _EBL11 TRRAP 238.6 10.46 0.383 MHC_I 7 150815308 _EBL11 AGAP3 412.7 27.6 0.24 MHC_I 8 21978233 _EBL11 HR 73.3 25.66 0.087 MHC_I 8 104413804 _EBL11 SLC25A32 137.2 13.22 0.391 MHC_I 8 125498537 _EBL11 RNF139 41.2 18.29 0.064 MHC_I 8 125568091 _EBL11 MTSS1 90.5 13.08 0.265 MHC_I 8 144391660 _EBL11 TOP1MT 31.7 45.48 0.071 MHC_I 8 144668451 _EBL11 EEF1D 423.3 405.35 0.116 MHC_I 8 145622567 _EBL11 CPSF1 253.4 68.73 0.288 MHC_I 9 5772989 _EBL11 KIAA1432 228.6 10.19 0.2 MHC_I 9 34241785 _EBL11 UBAP1 29.3 28.49 0.092 MHC_I 9 35846946 _EBL11 TMEM8B 94.7 14.51 0.25 MHC_I

9 36222777 _EBL11 GNE 469 39.63 0.054 MHC_I 9 37442136 _EBL11 ZBTB5 37 11.39 0.094 MHC_I 9 100407441 _EBL11 NCBP1 441.8 20.27 0.053 MHC_I 9 112153825 _EBL11 PTPN3 338 25.18 0.123 MHC_I 9 132396373 _EBL11 NTMT1 293.1 39.47 0.089 MHC_I 9 135796795 _EBL11 TSC1 239.7 17.83 0.265 MHC_I X 40571440 _EBL11 MED14 93.4 24.19 0.107 MHC_I X 41428923 _EBL11 CASK 20.8 26.09 0.086 MHC_I X 71715059 _EBL11 HDAC8 179.3 14.61 0.25 MHC_I X 129270668 _EBL11 AIFM1 80.7 46.32 0.063 MHC_I 1 192993039 _EBL13 UCHL5 121.2 13.21 0.054 MHC_I 12 7362390 _EBL13 PEX5 27.9 17.97 0.063 MHC_I 15 23931544 _EBL13 NDN 86.2 14.55 0.097 MHC_I 19 17424837 _EBL13 DDA1 84 15.91 0.055 MHC_I 19 33137455 _EBL13 ANKRD27 304.8 16.18 0.158 MHC_I 19 50512555 _EBL13 VRK3 336.2 31.47 0.056 MHC_I 22 36537393 _EBL13 APOL3 34 13.06 0.061 MHC_I 22 50894811 _EBL13 SBF1 109.9 14.86 0.128 MHC_I 22 51009381 _EBL13 CPT1B 139.6 12.21 0.063 MHC_I 3 49463821 _EBL13 NICN1 457.1 10.01 0.154 MHC_I 3 127294066 _EBL13 TPRA1 364.1 27.26 0.051 MHC_I 6 151775768 _EBL13 C6orf211 154.7 15.03 0.114 MHC_I 9 100675749 _EBL13 C9orf156 181.8 12.64 0.214 MHC_I 11 6412879 _EBL18 SMPD1 209.6 14.9 0.286 MHC_I 11 68566774 _EBL18 CPT1A 193.3 23.55 0.12 MHC_I 14 24658649 _EBL18 TM9SF1 80.4 18.95 0.081 MHC_I 16 67477072 _EBL18 ATP6V0D1 54.9 100.79 0.16 MHC_I 2 28004495 _EBL18 RBKS 117 16.81 0.077 MHC_I 2 32117104 _EBL18 MEMO1 6.8 12.28 0.081 MHC_I 9 110249993 _EBL18 KLF4 27.4 60.56 0.086 MHC_I 1 150443672 _EBL20 RPRD2 104.2 15.97 0.137 MHC_I

1 151261988 _EBL20 ZNF687 208 15.02 0.115 MHC_I 1 197070180 _EBL20 ASPM 108.5 11.87 0.176 MHC_I 1 214813895 _EBL20 CENPF 375.3 24.94 0.263 MHC_I 10 64893188 _EBL20 NRBF2 214.6 26.28 0.173 MHC_I 10 69669079 _EBL20 SIRT1 236.2 16.75 0.269 MHC_I 10 102116489 _EBL20 SCD 45.5 16.22 0.326 MHC_I 11 1502029 _EBL20 MOB2 295 42.17 0.068 MHC_I 11 47595290 _EBL20 KBTBD4 136.4 12.11 0.239 MHC_I 11 65367161 _EBL20 MAP3K11 393.8 41.19 0.414 MHC_I 11 67413258 _EBL20 ACY3 134.7 16.91 0.115 MHC_I 11 74336498 _EBL20 POLD3 112.6 16.78 0.172 MHC_I 12 7287957 _EBL20 CTN3 359.2 14.25 0.097 MHC_I 12 49170986 _EBL20 ADCY6 493.3 39.84 0.088 MHC_I 12 51389433 _EBL20 SLC11A2 180 31.42 0.082 MHC_I 12 57581052 _EBL20 LRP1 302.1 20.18 0.333 MHC_I 12 96131660 _EBL20 NTN4 22.8 29.41 0.052 MHC_I 12 113398998 _EBL20 OAS3 60.1 19.97 0.233 MHC_I 13 25832766 _EBL20 MTMR6 58.4 18.18 0.106 MHC_I 13 86368191 _EBL20 SLITRK6 249.5 23.57 0.147 MHC_I 14 32561374 _EBL20 ARHGAP5 473.7 27.82 0.154 MHC_I 14 50092499 _EBL20 DNAAF2 391.2 13.65 0.094 MHC_I 14 73425409 _EBL20 DCAF4 100.9 18.17 0.176 MHC_I 14 74192807 _EBL20 ELMSAN1 12 10.56 0.4 MHC_I 14 88904182 _EBL20 SPATA7 123.1 13.6 0.2 MHC_I 15 35149234 _EBL20 AQR 259.6 25.02 0.073 MHC_I 15 52506872 _EBL20 MYO5C 88.7 35.08 0.44 MHC_I 15 57565319 _EBL20 TCF12 186.3 39.23 0.426 MHC_I 15 78294061 _EBL20 TBC1D2B 22.6 31.67 0.076 MHC_I 16 2034824 _EBL20 GFER 44.5 23.79 0.053 MHC_I 16 2256513 _EBL20 MT8 101 46.99 0.32 MHC_I 16 15178538 _EBL20 RRN3 34.4 33.48 0.078 MHC_I

16 19455524 _EBL20 TMC5 24.9 25.07 0.271 MHC_I 16 29791468 _EBL20 ZG16 407.2 69.24 0.053 MHC_I 16 57685292 _EBL20 GPR56 246.9 90.15 0.065 MHC_I 16 87446394 _EBL20 ZCCHC14 359.9 13.17 0.407 MHC_I 17 16256369 _EBL20 CENPV 169.4 15.07 0.156 MHC_I 17 57644052 _EBL20 DHX40 73.9 40.49 0.056 MHC_I 17 60685402 _EBL20 TLK2 337.7 14.81 0.241 MHC_I 17 61908527 _EBL20 PSMC5 456.9 153.78 0.07 MHC_I 17 72951900 _EBL20 HID1 32.9 61.3 0.091 MHC_I 17 73565135 _EBL20 LLGL2 48.4 112.45 0.059 MHC_I 17 79077889 _EBL20 BAIAP2 439.8 13.45 0.135 MHC_I 18 77894507 _EBL20 ADNP2 461.9 13.53 0.217 MHC_I 19 45349844 _EBL20 PVRL2 156.7 75.21 0.355 MHC_I 19 53348448 _EBL20 ZNF468 252.2 14.91 0.2 MHC_I 2 15746146 _EBL20 DDX1 23.5 91.42 0.106 MHC_I 2 25042868 _EBL20 ADCY3 75.5 15.38 0.079 MHC_I 2 55906840 _EBL20 PNPT1 460.2 17.4 0.109 MHC_I 2 61552564 _EBL20 USP34 209.4 20.65 0.407 MHC_I 2 207018393 _EBL20 NDUFS1 33.3 58.97 0.086 MHC_I 2 223423144 _EBL20 SGPP2 158.5 32.56 0.096 MHC_I 2 228197140 _EBL20 MFF 297.6 54.4 0.07 MHC_I 20 3128351 _EBL20 FASTKD5 90.9 12.38 0.083 MHC_I 20 31041135 _EBL20 C20orf112 52.5 27.74 0.113 MHC_I 20 37580382 _EBL20 FAM83D 398.2 34.26 0.067 MHC_I 20 50273482 _EBL20 ATP9A 408.5 66.82 0.208 MHC_I 20 62575924 _EBL20 UCKL1 101 28.35 0.161 MHC_I 22 21150444 _EBL20 PI4KA 128.6 35.15 0.2 MHC_I 3 47125478 _EBL20 SETD2 451.1 19.77 0.053 MHC_I 3 49053904 _EBL20 DALRD3 275.8 27.63 0.102 MHC_I 3 50356434 _EBL20 HYAL2 74.1 40.71 0.234 MHC_I 3 53914055 _EBL20 ACTR8 180.2 14.39 0.163 MHC_I

3 93598132 _EBL20 PROS1 87 23.97 0.125 MHC_I 3 101383533 _EBL20 ZBTB11 406.1 13.01 0.107 MHC_I 4 1987520 _EBL20 NELFA 201.8 23.28 0.416 MHC_I 4 48038104 _EBL20 NIPAL1 457 24.24 0.245 MHC_I 4 48559053 _EBL20 FRYL 341.4 59.31 0.116 MHC_I 4 123236709 _EBL20 KIAA1109 222.6 15.07 0.111 MHC_I 4 159642531 _EBL20 PPID 163.3 51.71 0.083 MHC_I 4 184432014 _EBL20 ING2 469.2 17.85 0.333 MHC_I 4 184614801 _EBL20 TRAPPC11 403.1 23.12 0.078 MHC_I 5 112200429 _EBL20 SRP19 46 30.93 0.244 MHC_I 5 114552595 _EBL20 PGGT1B 215.7 21.54 0.167 MHC_I 6 44102401 _EBL20 TMEM63B 35 35.92 0.265 MHC_I 6 160105934 _EBL20 SOD2 223.1 129.95 0.073 MHC_I 7 6845644 _EBL20 CCZ1B 170.4 46.5 0.115 MHC_I 7 130135262 _EBL20 MEST 93 54.73 0.126 MHC_I 8 21860740 _EBL20 XPO7 366 33.9 0.257 MHC_I 8 28633364 _EBL20 INTS9 134 17.55 0.143 MHC_I 8 38107309 _EBL20 DDHD2 15 16.41 0.2 MHC_I 8 90958486 _EBL20 NBN 376.7 31.73 0.071 MHC_I 8 101237499 _EBL20 SPAG1 103.4 22.07 0.096 MHC_I 8 145621703 _EBL20 CPSF1 417.4 36.35 0.175 MHC_I 9 91961803 _EBL20 SECISBP2 87 31.85 0.125 MHC_I 9 101900288 _EBL20 TGFBR1 128.6 22.01 0.349 MHC_I 9 104314450 _EBL20 RNF20 73.3 28.65 0.074 MHC_I 9 140353513 _EBL20 NSMF 114.5 21.5 0.143 MHC_I X 100268679 _EBL20 TRMT2B 246.9 18.45 0.182 MHC_I X 100268681 _EBL20 TRMT2B 450.6 18.45 0.182 MHC_I 1 85817249 _EBL23 DDAH1 69.4 60.41 0.087 MHC_I 1 115226910 _EBL23 AMPD1 15.2 12.96 0.111 MHC_I 10 123239442 _EBL23 FGFR2 135.2 23.41 0.083 MHC_I 11 64757200 _EBL23 BATF2 26.2 14.84 0.136 MHC_I

11 124495763 _EBL23 TBRG1 17.2 11.52 0.087 MHC_I 17 58040212 _EBL23 RNFT1 157.7 23.35 0.056 MHC_I 2 190331199 _EBL23 WDR75 10.2 16.53 0.075 MHC_I 3 49928891 _EBL23 MST1R 138.1 18.14 0.066 MHC_I 5 153755936 _EBL23 GALNT10 387 18 0.125 MHC_I 1 169993620 _EBL26 KIFAP3 169.3 34.02 0.058 MHC_I 10 135106659 _EBL26 TUBGCP2 91 23.96 0.067 MHC_I 11 9812155 _EBL26 SBF2 16.6 15.4 0.073 MHC_I 12 9750654 _EBL26 KLRB1 150.2 72.48 0.063 MHC_I 14 34419843 _EBL26 EGLN3 124.4 36.89 0.1 MHC_I 16 56419902 _EBL26 AMFR 56 45.49 0.053 MHC_I 16 67477072 _EBL26 ATP6V0D1 54.7 135.75 0.123 MHC_I 19 19758056 _EBL26 ATP13A1 14.9 19.62 0.061 MHC_I 19 19767849 _EBL26 ATP13A1 269.2 19.62 0.068 MHC_I 2 220089170 _EBL26 ATG9A 15.7 30.87 0.059 MHC_I 20 20024245 _EBL26 CRNKL1 56.6 20.93 0.072 MHC_I 3 52588824 _EBL26 PBRM1 4.6 13.44 0.129 MHC_I 3 56694766 _EBL26 FAM208A 112 15.68 0.125 MHC_I 3 171443809 _EBL26 PLD1 489.9 27.27 0.061 MHC_I 4 42454006 _EBL26 ATP8A1 28.1 33.22 0.054 MHC_I 5 94872769 _EBL26 TTC37 82 40.76 0.057 MHC_I 8 48882502 _EBL26 MCM4 84.6 26.09 0.09 MHC_I 8 126056809 _EBL26 KIAA0196 221.9 31.27 0.059 MHC_I X 2861115 _EBL26 ARSE 14.1 67.12 0.062 MHC_I X 96013177 _EBL26 DIAPH2 196.1 11.77 0.207 MHC_I X 154741338 _EBL26 TMLHE 146.5 18.16 0.115 MHC_I 12 12629910 _EBL3 DUSP16 476.5 14.96 0.056 MHC_I 12 71139785 _EBL3 PTPRR 295.1 24.37 0.057 MHC_I 12 107371883 _EBL3 MTERFD3 312 13.77 0.129 MHC_I 14 92621581 _EBL3 CPSF2 28 15 0.123 MHC_I 16 28167413 _EBL3 XPO6 83.8 22.96 0.072 MHC_I

16 28847378 _EBL3 ATXN2L 33.8 19.17 0.083 MHC_I 16 67477072 _EBL3 ATP6V0D1 20.7 145.32 0.057 MHC_I 17 15878187 _EBL3 ADORA2B 77.9 24.38 0.056 MHC_I 17 27182148 _EBL3 ERAL1 28.9 50.5 0.065 MHC_I 17 62290764 _EBL3 TEX2 22.3 10.91 0.107 MHC_I 18 47110043 _EBL3 LIPG 26 10.92 0.075 MHC_I 19 2767580 _EBL3 SGTA 418.4 40.23 0.056 MHC_I 19 41826329 _EBL3 CCDC97 330.6 11.33 0.167 MHC_I 19 42402722 _EBL3 ARHGEF1 354.7 22.61 0.08 MHC_I 2 27601679 _EBL3 ZNF513 45.9 20.01 0.103 MHC_I 2 86357778 _EBL3 PTCD3 174.5 18.13 0.069 MHC_I 2 97377608 _EBL3 LMAN2L 10.1 12.82 0.103 MHC_I 3 133375600 _EBL3 TOPBP1 40.1 10.85 0.217 MHC_I 4 152070653 _EBL3 SH3D19 283.6 35.35 0.06 MHC_I 4 184572187 _EBL3 RWDD4 142.6 20.02 0.051 MHC_I 5 36170455 _EBL3 SKP2 329.4 14.74 0.241 MHC_I 6 31762847 _EBL3 VARS 309.4 20.87 0.19 MHC_I 6 42994922 _EBL3 RRP36 157 41.04 0.07 MHC_I 6 131917102 _EBL3 MED23 63.8 11.37 0.133 MHC_I 7 99490177 _EBL3 TRIM4 266.4 15.06 0.062 MHC_I X 149814229 _EBL3 MTM1 209.8 18.06 0.063 MHC_I 12 6966847 _EBL5 USP5 15.7 20.45 0.103 MHC_I 12 50482355 _EBL5 SMARCD1 367.4 10.34 0.111 MHC_I 16 2025679 _EBL5 TBL3 256.9 10.17 0.111 MHC_I 17 36958403 _EBL5 CWC25 77.6 10.53 0.128 MHC_I 3 145828134 _EBL5 PLOD2 290.2 14.79 0.069 MHC_I 6 13306706 _EBL5 TBC1D7 68.1 23.93 0.062 MHC_I 10 103344393 _EBL7 POLL 168.2 16.33 0.111 MHC_I 12 72025969 _EBL7 ZFC3H1 33 18.41 0.2 MHC_I 12 107391764 _EBL7 CRY1 27.3 10.14 0.192 MHC_I 12 113436141 _EBL7 OAS2 71.9 10.66 0.286 MHC_I

12 124233229 _EBL7 ATP6V0A2 242.8 11.16 0.243 MHC_I 14 93720040 _EBL7 BTBD7 40.4 15.48 0.091 MHC_I 15 35176905 _EBL7 AQR 184.6 21.2 0.059 MHC_I 15 77473399 _EBL7 PEAK1 407.2 14.76 0.176 MHC_I 16 15698092 _EBL7 KIAA0430 350.4 27.17 0.051 MHC_I 17 40441996 _EBL7 STAT5A 67.2 12.91 0.152 MHC_I 17 43192550 _EBL7 PLCD3 20.8 147.09 0.071 MHC_I 17 55027396 _EBL7 COIL 415.7 17.24 0.15 MHC_I 17 74739518 _EBL7 MFSD11 54.2 22.71 0.071 MHC_I 17 80888479 _EBL7 TBCD 187.5 21.36 0.068 MHC_I 19 4054678 _EBL7 ZBTB7A 145.3 40.83 0.074 MHC_I 2 42909652 _EBL7 MTA3 133.3 24.73 0.06 MHC_I 2 86849950 _EBL7 RNF103 6.5 68.34 0.053 MHC_I 2 176857119 _EBL7 KIAA1715 262.7 20.15 0.103 MHC_I 3 197023258 _EBL7 DLG1 69.6 38.2 0.052 MHC_I 4 187000145 _EBL7 TLR3 25.6 20.2 0.122 MHC_I 4 187629945 _EBL7 FAT1 377.8 37.68 0.093 MHC_I 5 205801 _EBL7 CCDC127 194.4 15.48 0.118 MHC_I 5 16794906 _EBL7 MYO10 376.1 25.5 0.061 MHC_I 6 17608468 _EBL7 FAM8A1 78.1 41.66 0.08 MHC_I 6 36294836 _EBL7 C6orf222 15.6 16.18 0.093 MHC_I 6 99347304 _EBL7 FBXL4 25.6 11.32 0.125 MHC_I 7 1514377 _EBL7 INTS1 92 31.23 0.052 MHC_I 7 2278515 _EBL7 FTSJ2 351.1 21.47 0.158 MHC_I 7 11022426 _EBL7 PHF14 313.9 16.3 0.194 MHC_I 8 87460494 _EBL7 WWP1 263.6 30.64 0.069 MHC_I 9 123538378 _EBL7 FBXW2 128.6 18.09 0.091 MHC_I 9 135202094 _EBL7 SETX 430.2 18.16 0.109 MHC_I X 129208564 _EBL7 ELF4 67.5 44.81 0.138 MHC_I 1 1231863 _EBL9 ACAP3 404.6 19.43 0.365 MHC_I 1 1455550 _EBL9 ATAD3A 234.8 33.73 0.211 MHC_I

1 1571750 _EBL9 CDK11B 118.2 76.18 0.32 MHC_I 1 2235424 _EBL9 SKI 61.6 20.89 0.378 MHC_I 1 11855218 _EBL9 MTHFR 46.8 15.18 0.081 MHC_I 1 12343399 _EBL9 VPS13D 13.5 13.79 0.087 MHC_I 1 16043236 _EBL9 PLEKHM2 69.6 26.95 0.25 MHC_I 1 16456779 _EBL9 EPHA2 65.7 21.07 0.27 MHC_I 1 21100060 _EBL9 HP1BP3 230 89.2 0.053 MHC_I 1 22050473 _EBL9 USP48 273.7 39.19 0.075 MHC_I 1 27736317 _EBL9 WASF2 75 76.25 0.231 MHC_I 1 33245822 _EBL9 YARS 294.4 38.61 0.294 MHC_I 1 33408010 _EBL9 RNF19B 410.5 42.04 0.053 MHC_I 1 35457852 _EBL9 ZMYM6 422.8 12.81 0.063 MHC_I 1 44424161 _EBL9 IPO13 31.2 15.44 0.449 MHC_I 1 46485343 _EBL9 MAST2 404.7 39.35 0.217 MHC_I 1 109200117 _EBL9 HENMT1 286.3 27.94 0.087 MHC_I 1 117529557 _EBL9 PTGFRN 113.4 42.02 0.167 MHC_I 1 151149169 _EBL9 VPS72 7.3 38.61 0.071 MHC_I 1 151849494 _EBL9 THEM4 27 10.54 0.051 MHC_I 1 180849235 _EBL9 XPR1 9.5 12.11 0.063 MHC_I 1 208390403 _EBL9 PLXNA2 280.7 18.61 0.07 MHC_I 1 226016576 _EBL9 EPHX1 330 81.22 0.333 MHC_I 1 235298999 _EBL9 RBM34 321.1 45.51 0.069 MHC_I 1 236148745 _EBL9 NID1 64.9 21.02 0.053 MHC_I 1 236208941 _EBL9 NID1 42.6 21.02 0.154 MHC_I 10 24873775 _EBL9 ARHGAP21 11.3 33.44 0.272 MHC_I 10 69565358 _EBL9 DNAJC12 46.7 40.27 0.054 MHC_I 10 97919840 _EBL9 ZNF518A 59.8 19.13 0.176 MHC_I 10 115922769 _EBL9 C10orf118 106.8 26.83 0.067 MHC_I 10 120917400 _EBL9 SFXN4 172.2 38.6 0.056 MHC_I 10 121595149 _EBL9 MCMBP 279.2 36.27 0.061 MHC_I 11 721688 _EBL9 EPS8L2 51.2 146.22 0.279 MHC_I

11 3380754 _EBL9 ZNF195 56.9 14.94 0.163 MHC_I 11 57188468 _EBL9 SLC43A3 438 14.3 0.091 MHC_I 11 61295413 _EBL9 SYT7 35.5 19.83 0.091 MHC_I 11 63667450 _EBL9 MARK2 70 43.13 0.136 MHC_I 11 64600378 _EBL9 CDC42BPG 10.4 25.31 0.317 MHC_I 11 64645826 _EBL9 EHD1 370.5 45.73 0.172 MHC_I 11 64863915 _EBL9 VPS51 25.2 63.65 0.068 MHC_I 11 65413964 _EBL9 SIPA1 19.8 17.15 0.081 MHC_I 11 67259691 _EBL9 PITPNM1 316.3 30.15 0.351 MHC_I 11 72425217 _EBL9 ARAP1 34.1 45.84 0.067 MHC_I 11 111594812 _EBL9 SIK2 49.6 16.13 0.133 MHC_I 11 118971735 _EBL9 DPAGT1 6.1 34.89 0.06 MHC_I 12 475171 _EBL9 KDM5A 15.4 14.58 0.12 MHC_I 12 6438503 _EBL9 TNFRSF1A 294.9 97.91 0.143 MHC_I 12 26580923 _EBL9 ITPR2 16.5 16.37 0.069 MHC_I 12 33049512 _EBL9 PKP2 5.2 81.59 0.069 MHC_I 12 56347514 _EBL9 DGKA 65.4 54.93 0.151 MHC_I 12 56817128 _EBL9 TIMELESS 98.7 23.41 0.07 MHC_I 12 62979217 _EBL9 MON2 88.3 14.84 0.079 MHC_I 12 122724459 _EBL9 VPS33A 438.5 22.27 0.061 MHC_I 13 26788166 _EBL9 RNF6 207 35.68 0.088 MHC_I 13 79940860 _EBL9 RBM26 241.4 24.89 0.123 MHC_I 14 20864059 _EBL9 TEP1 220.2 24.58 0.093 MHC_I 14 23549379 _EBL9 ACIN1 16.1 93.46 0.109 MHC_I 14 24885568 _EBL9 NYNRIN 6.2 21.19 0.405 MHC_I 14 61952305 _EBL9 PRKCH 298.7 12.06 0.1 MHC_I 14 69376696 _EBL9 ACTN1 324.9 68.29 0.051 MHC_I 14 75265068 _EBL9 YLPM1 482 17.5 0.23 MHC_I 14 75528445 _EBL9 ACYP1 141.4 30.51 0.176 MHC_I 14 95573991 _EBL9 DICER1 61.2 29.4 0.068 MHC_I 15 44856787 _EBL9 SPG11 299.7 33.07 0.056 MHC_I

15 49325188 _EBL9 SECISBP2L 128.6 18.75 0.261 MHC_I 15 57523401 _EBL9 TCF12 62.2 155.93 0.273 MHC_I 15 59964846 _EBL9 BNIP2 38.6 26.96 0.081 MHC_I 15 64669047 _EBL9 KIAA0101 113.3 23.47 0.066 MHC_I 16 427044 _EBL9 TMEM8A 385.6 77.44 0.053 MHC_I 16 570188 _EBL9 RAB11FIP3 219.2 22.87 0.152 MHC_I 16 1867176 _EBL9 HAGH 22.2 41.18 0.053 MHC_I 16 2126131 _EBL9 TSC2 6.7 37.49 0.234 MHC_I 16 2147162 _EBL9 PKD1 408.6 20.29 0.107 MHC_I 16 11785542 _EBL9 TXNDC11 55 58.72 0.065 MHC_I 16 29856073 _EBL9 MVP 264.7 365.36 0.235 MHC_I 16 67227020 _EBL9 E2F4 41.8 85.09 0.078 MHC_I 16 89217537 _EBL9 ACSF3 287.7 20.39 0.158 MHC_I 17 3851056 _EBL9 ATP2A3 64.5 204.38 0.093 MHC_I 17 3967806 _EBL9 ZZEF1 126.9 33.84 0.069 MHC_I 17 4439660 _EBL9 SPNS2 18 14.22 0.128 MHC_I 17 4793023 _EBL9 MINK1 245.7 104.25 0.341 MHC_I 17 7287344 _EBL9 TNK1 23.3 16.45 0.294 MHC_I 17 7760107 _EBL9 MD1 73.5 85.56 0.069 MHC_I 17 8092505 _EBL9 C17orf59 145.4 12.72 0.174 MHC_I 17 29632041 _EBL9 EVI2B 74.3 37.61 0.083 MHC_I 17 30692357 _EBL9 ZNF207 81.1 132.34 0.262 MHC_I 17 34883510 _EBL9 MYO19 239.2 44.33 0.344 MHC_I 17 37881332 _EBL9 ERBB2 31.3 176.97 0.265 MHC_I 17 40257879 _EBL9 DHX58 7.7 10.02 0.1 MHC_I 17 40948220 _EBL9 WNK4 14.7 43.13 0.229 MHC_I 17 43531117 _EBL9 PLEKHM1 25.9 26.76 0.121 MHC_I 17 58035801 _EBL9 RNFT1 75.2 20.5 0.16 MHC_I 17 58541426 _EBL9 APPBP2 367.6 15.12 0.089 MHC_I 17 76134212 _EBL9 TMC8 6.2 12.49 0.102 MHC_I 18 5423410 _EBL9 EPB41L3 295.9 27.07 0.063 MHC_I

19 625190 _EBL9 POLRMT 316.7 24.28 0.109 MHC_I 19 990868 _EBL9 WDR18 161 33.71 0.2 MHC_I 19 1255534 _EBL9 MIDN 239.2 50.87 0.098 MHC_I 19 1979174 _EBL9 CSNK1G2 382 44.56 0.242 MHC_I 19 4328730 _EBL9 STAP2 103.3 133.91 0.311 MHC_I 19 10202178 _EBL9 C19orf66 9.5 25.87 0.225 MHC_I 19 10439688 _EBL9 RAVER1 303.8 41.48 0.175 MHC_I 19 13051678 _EBL9 CALR 146.2 891.28 0.134 MHC_I 19 13216116 _EBL9 TRMT1 169.2 31.88 0.108 MHC_I 19 13247130 _EBL9 NACC1 83.7 36.3 0.244 MHC_I 19 14581010 _EBL9 PKN1 47.6 26.51 0.1 MHC_I 19 19459998 _EBL9 MAU2 12.5 26.73 0.288 MHC_I 19 33137391 _EBL9 ANKRD27 414.2 28.49 0.083 MHC_I 19 46375988 _EBL9 FOXA3 3.3 42.7 0.104 MHC_I 19 50059812 _EBL9 NOSIP 113.5 75.36 0.367 MHC_I 19 52448812 _EBL9 ZNF613 220.2 11.47 0.19 MHC_I 19 55789019 _EBL9 HSPBP1 60 42.31 0.057 MHC_I 2 10799303 _EBL9 NOL10 33 19.01 0.095 MHC_I 2 43452248 _EBL9 ZFP36L2 225.6 206.32 0.162 MHC_I 2 54101570 _EBL9 PSME4 27.2 18.72 0.094 MHC_I 2 55470668 _EBL9 MTIF2 185.7 55.73 0.057 MHC_I 2 61441772 _EBL9 USP34 403.2 25.92 0.163 MHC_I 2 75897272 _EBL9 GCFC2 309.6 11.01 0.235 MHC_I 2 120980180 _EBL9 TMEM185B 15.2 12.96 0.339 MHC_I 2 159490705 _EBL9 PKP4 221 37.38 0.052 MHC_I 2 170460570 _EBL9 PPIG 225.1 62.16 0.29 MHC_I 2 230675881 _EBL9 TRIP12 129.1 51.12 0.155 MHC_I 20 30897620 _EBL9 KIF3B 191.2 36.43 0.247 MHC_I 20 32247356 _EBL9 NECAB3 353.8 25.7 0.4 MHC_I 20 33623034 _EBL9 TRPC4AP 43.6 68.31 0.055 MHC_I 20 43243243 _EBL9 PKIG 304.3 64.79 0.157 MHC_I

20 49509089 _EBL9 ADNP 51.6 39.08 0.097 MHC_I 21 34889364 _EBL9 GART 78.3 47.42 0.086 MHC_I 21 43711228 _EBL9 ABCG1 38.4 23.71 0.106 MHC_I 22 21984001 _EBL9 YDJC 19 18.86 0.471 MHC_I 22 22294047 _EBL9 PPM1F 80.6 12.47 0.175 MHC_I 22 36701983 _EBL9 MYH9 337.8 335.27 0.057 MHC_I 22 38894446 _EBL9 DDX17 37.6 220.77 0.241 MHC_I 22 50659306 _EBL9 TUBGCP6 12.5 22.16 0.061 MHC_I 22 50716563 _EBL9 PLXNB2 22 153.08 0.106 MHC_I 3 10123118 _EBL9 FANCD2 24.8 14.4 0.074 MHC_I 3 13363302 _EBL9 NUP210 84.3 22.46 0.26 MHC_I 3 110852822 _EBL9 PVRL3 57.5 42.45 0.211 MHC_I 3 110912202 _EBL9 PVRL3 364.6 42.45 0.232 MHC_I 3 113218377 _EBL9 SPICE1 414.9 11.34 0.079 MHC_I 3 131188575 _EBL9 MRPL3 407.3 101.53 0.248 MHC_I 3 148768078 _EBL9 HLTF 205.1 15.47 0.125 MHC_I 3 172115129 _EBL9 FNDC3B 280.4 32.87 0.056 MHC_I 3 183885810 _EBL9 DVL3 395.1 35.49 0.207 MHC_I 3 184294687 _EBL9 EPHB3 15.5 81.37 0.073 MHC_I 4 955618 _EBL9 DGKQ 468.5 34.7 0.338 MHC_I 4 2934900 _EBL9 MFSD10 337.5 40.13 0.194 MHC_I 4 48567607 _EBL9 FRYL 48.4 51.86 0.066 MHC_I 4 79793027 _EBL9 BMP2K 301.4 20.81 0.065 MHC_I 4 113353595 _EBL9 ALPK1 79 12.71 0.138 MHC_I 4 122723894 _EBL9 EXOSC9 99 22.91 0.128 MHC_I 4 187549341 _EBL9 FAT1 258.9 58.85 0.067 MHC_I 5 306758 _EBL9 PDCD6 243.8 182.19 0.324 MHC_I 5 10430040 _EBL9 6-Mar 5.2 39.52 0.297 MHC_I 5 36985591 _EBL9 NIPBL 198.9 22.28 0.091 MHC_I 5 60050576 _EBL9 ELOVL7 15.3 24.32 0.059 MHC_I 5 72851344 _EBL9 ANKRA2 216 16.43 0.104 MHC_I

5 74041570 _EBL9 GFM2 185.9 24.57 0.122 MHC_I 5 76745613 _EBL9 WDR41 379 18.65 0.08 MHC_I 5 79933757 _EBL9 DHFR 374.1 73.04 0.065 MHC_I 5 95234316 _EBL9 ELL2 220.4 12.28 0.054 MHC_I 5 130721248 _EBL9 CDC42SE2 142.3 88.37 0.218 MHC_I 5 162870695 _EBL9 CCNG1 52.9 132.96 0.161 MHC_I 5 177569638 _EBL9 RMND5B 469 32.59 0.233 MHC_I 6 31926206 _EBL9 NELFE 12.9 84.3 0.41 MHC_I 6 34214562 _EBL9 C6orf1 15.6 18.21 0.053 MHC_I 6 39162413 _EBL9 KCNK5 329.9 23.33 0.152 MHC_I 6 42937639 _EBL9 PEX6 17.3 19.3 0.2 MHC_I 6 42946341 _EBL9 PEX6 254.2 19.3 0.109 MHC_I 6 43639557 _EBL9 MRPS18A 15.8 90.89 0.109 MHC_I 6 99374699 _EBL9 FBXL4 73.9 15.05 0.111 MHC_I 6 151766570 _EBL9 RMND1 32.5 21.64 0.091 MHC_I 7 17937003 _EBL9 SNX13 392.5 23.47 0.125 MHC_I 7 35053220 _EBL9 DPY19L1 51.2 17.98 0.091 MHC_I 7 45140880 _EBL9 TBRG4 374.1 78.71 0.312 MHC_I 7 72892029 _EBL9 BAZ1B 486.2 38.34 0.071 MHC_I 7 76112243 _EBL9 DTX2 7.6 26.95 0.133 MHC_I 7 100488847 _EBL9 ACHE 133.2 17.52 0.292 MHC_I 7 143002054 _EBL9 CASP2 133.5 31.36 0.333 MHC_I 7 150730730 _EBL9 ABCB8 72.8 11.68 0.253 MHC_I 8 22267579 _EBL9 SLC39A14 203.7 107.13 0.06 MHC_I 8 41794936 _EBL9 KAT6A 7.5 15.89 0.079 MHC_I 8 61765468 _EBL9 CHD7 56.4 10.04 0.286 MHC_I 8 62460647 _EBL9 ASPH 85 100.53 0.069 MHC_I 8 74529570 _EBL9 STAU2 12.9 24.13 0.075 MHC_I 8 134488056 _EBL9 ST3GAL1 229.3 12.92 0.138 MHC_I 8 141810636 _EBL9 PTK2 175.2 47.62 0.051 MHC_I 8 145111352 _EBL9 OPLAH 94.9 19.32 0.104 MHC_I

9 152043 _EBL9 CBWD1 157 16.98 0.5 MHC_I 9 5732473 _EBL9 KIAA1432 257.1 11.98 0.3 MHC_I 9 5968945 _EBL9 KIAA2026 67.1 10.3 0.167 MHC_I 9 20365672 _EBL9 MLLT3 68.4 28.95 0.085 MHC_I 9 77455075 _EBL9 TRPM6 395.1 18.5 0.115 MHC_I 9 95030500 _EBL9 IARS 41.1 64.53 0.082 MHC_I 9 100437746 _EBL9 XPA 206.2 13.76 0.167 MHC_I 9 101589145 _EBL9 GALNT12 35.6 104.19 0.179 MHC_I 9 110248156 _EBL9 KLF4 43.7 143.31 0.062 MHC_I 9 124118368 _EBL9 STOM 21.3 19.91 0.091 MHC_I 9 130869309 _EBL9 SLC25A25 150.5 18.31 0.194 MHC_I 9 130984829 _EBL9 DNM1 274.8 13.42 0.567 MHC_I 9 134021644 _EBL9 NUP214 54.6 27.68 0.263 MHC_I 9 134090719 _EBL9 NUP214 365.9 27.68 0.051 MHC_I 9 134458025 _EBL9 RAPGEF1 404.6 29.09 0.055 MHC_I X 3544497 _EBL9 PRKX 87.5 20.22 0.058 MHC_I X 7252131 _EBL9 STS 412.2 14.83 0.178 MHC_I X 39932396 _EBL9 BCOR 13.2 17.63 0.073 MHC_I X 114864240 _EBL9 P3 35.3 26.96 0.089 MHC_I X 152959811 _EBL9 SLC6A8 30.3 110.6 0.454 MHC_I X 152981045 _EBL9 BCAP31 62.7 310.72 0.27 MHC_I 1 955728 _T1 AGRN 250.4 38.67 0.447 MHC_I 1 11182058 _T1 MTOR 103.6 17.92 0.079 MHC_I 1 46655596 _T1 POMGNT1 45.4 29.79 0.078 MHC_I 1 156252454 _T1 SMG5 5 21.54 0.267 MHC_I 1 162769548 _T1 HSD17B7 47.8 29.33 0.083 MHC_I 1 220162105 _T1 EPRS 95.9 43.79 0.083 MHC_I 10 88820730 _T1 GLUD1 291.4 68.66 0.109 MHC_I 11 3707282 _T1 NUP98 198.9 25.1 0.122 MHC_I 11 6629392 _T1 ILK 33.5 75.69 0.077 MHC_I 11 9983535 _T1 SBF2 283.7 10.46 0.435 MHC_I

11 62496412 _T1 TTC9C 14.5 16.17 0.068 MHC_I 12 72036265 _T1 ZFC3H1 87.2 18.42 0.409 MHC_I 12 99042471 _T1 APAF1 50.9 10.78 0.407 MHC_I 12 121783822 _T1 ANAPC5 16 27.53 0.386 MHC_I 12 133249803 _T1 POLE 6.5 12 0.071 MHC_I 13 103266498 _T1 TPP2 9.3 13.7 0.071 MHC_I 13 103292625 _T1 TPP2 94.2 13.7 0.528 MHC_I 13 103330653 _T1 TPP2 40.7 13.7 0.339 MHC_I 13 114288254 _T1 TFDP1 28.4 22.41 0.456 MHC_I 14 69256455 _T1 ZFP36L1 200.2 16.07 0.366 MHC_I 14 77935551 _T1 AHSA1 29.2 109.17 0.082 MHC_I 16 1498451 _T1 CLCN7 100.6 25.12 0.253 MHC_I 16 2814014 _T1 SRRM2 188.9 56.56 0.073 MHC_I 16 9017115 _T1 USP7 308.8 31.69 0.08 MHC_I 16 29465368 _T1 BOLA2 73.3 158.48 0.138 MHC_I 16 31049934 _T1 STX4 124.9 26.6 0.235 MHC_I 16 57111659 _T1 NLRC5 85.6 36.72 0.072 MHC_I 16 74666475 _T1 RFWD3 80.8 12.54 0.275 MHC_I 17 4619810 _T1 ARRB2 6.3 20.19 0.239 MHC_I 17 15984038 _T1 NCOR1 315.1 35.91 0.211 MHC_I 17 78355358 _T1 RNF213 9.1 129.82 0.31 MHC_I 18 33800145 _T1 MOCOS 135.5 23.34 0.333 MHC_I 19 40883695 _T1 PLD3 53.8 26.69 0.118 MHC_I 19 45397092 _T1 TOMM40 325.4 14.96 0.435 MHC_I 2 32773057 _T1 BIRC6 433.3 27.91 0.074 MHC_I 2 46608779 _T1 EPAS1 130.3 19.56 0.081 MHC_I 2 99998635 _T1 EIF5B 472.8 49.13 0.476 MHC_I 2 128038115 _T1 ERCC3 27.1 20.07 0.348 MHC_I 2 169699563 _T1 NOSTRIN 159 13.17 0.148 MHC_I 20 2633947 _T1 NOP56 284.5 78.19 0.429 MHC_I 20 18516304 _T1 SEC23B 125 57.16 0.412 MHC_I

20 25274828 _T1 PYGB 309.9 17.15 0.061 MHC_I 21 34924324 _T1 SON 47.2 56.53 0.5 MHC_I 22 24439373 _T1 CABIN1 136.2 28.94 0.422 MHC_I 22 41919266 _T1 ACO2 123.9 70.03 0.09 MHC_I 22 42606271 _T1 TCF20 59.7 13.03 0.286 MHC_I 3 9833114 _T1 TADA3 328.8 15.9 0.403 MHC_I 3 47036795 _T1 NBEAL2 13.9 15.11 0.154 MHC_I 3 69124637 _T1 UBA3 14.9 18.66 0.337 MHC_I 3 110837594 _T1 PVRL3 5.1 10.69 0.213 MHC_I 3 122414425 _T1 PARP14 109.6 73.63 0.073 MHC_I 3 133327489 _T1 TOPBP1 341.8 10.73 0.161 MHC_I 4 435858 _T1 ZNF721 97.8 14.19 0.44 MHC_I 5 102249702 _T1 PAM 126.5 27.57 0.368 MHC_I 5 131819674 _T1 IRF1 131.4 19.1 0.051 MHC_I 5 167943838 _T1 RARS 65 51.05 0.287 MHC_I 6 13321256 _T1 TBC1D7 19.2 15.97 0.204 MHC_I 6 33655905 _T1 ITPR3 1.9 37.11 0.086 MHC_I 6 80910738 _T1 BCKDHB 304.3 35 0.231 MHC_I 6 143806363 _T1 PEX3 172.7 10.34 0.429 MHC_I 7 100849626 _T1 PLOD3 147.7 30.92 0.392 MHC_I 8 118847729 _T1 EXT1 188.7 17.96 0.253 MHC_I 8 141407810 _T1 TRAPPC9 94.7 23.41 0.073 MHC_I 8 144941319 _T1 EPPK1 23.2 26.26 0.535 MHC_I X 76939958 _T1 ATRX 167.3 23.41 0.079 MHC_I 1 16462199 _T2 EPHA2 160.9 14.37 0.122 MHC_I 1 22965632 _T2 C1QA 141 20.92 0.06 MHC_I 1 32782323 _T2 HDAC1 28.6 68.91 0.524 MHC_I 1 59248285 _T2 JUN 161.1 28.32 0.188 MHC_I 1 89476705 _T2 GBP3 99.5 28.79 0.667 MHC_I 1 148010991 _T2 NBPF14 422.3 216.46 0.333 MHC_I 1 182822461 _T2 DHX9 395.6 96.95 0.17 MHC_I

1 186329124 _T2 TPR 37.6 31.57 0.115 MHC_I 1 245021483 _T2 HNRNPU 64.2 58.32 0.5 MHC_I 10 89720812 _T2 PTEN 292 18.91 0.322 MHC_I 11 13736194 _T2 FAR1 37.1 11.35 0.397 MHC_I 11 34112143 _T2 CAPRIN1 26.1 79.47 0.097 MHC_I 11 130066291 _T2 ST14 26 95.8 0.319 MHC_I 12 6969641 _T2 USP5 249.7 33.3 0.082 MHC_I 12 31255384 _T2 DDX11 150.8 24.26 0.067 MHC_I 12 62783404 _T2 USP15 52.3 11.05 0.123 MHC_I 14 21875095 _T2 CHD8 70.7 10.77 0.115 MHC_I 14 50971538 _T2 MAP4K5 291.8 10.73 0.364 MHC_I 14 72128104 _T2 SIPA1L1 404.3 12.01 0.146 MHC_I 14 75367836 _T2 DT 187.5 35.13 0.174 MHC_I 14 91948172 _T2 SMEK1 43.6 12.16 0.086 MHC_I 14 97299907 _T2 VRK1 66.7 37.96 0.128 MHC_I 15 28483285 _T2 HERC2 139.8 13.2 0.11 MHC_I 15 42525427 _T2 TMEM87A 21.1 36.19 0.079 MHC_I 16 18853054 _T2 SMG1 8.7 21.57 0.39 MHC_I 16 28123326 _T2 XPO6 97.2 15.66 0.227 MHC_I 16 47727378 _T2 PHKB 88.1 32.8 0.238 MHC_I 16 67477072 _T2 ATP6V0D1 134.8 18.22 0.149 MHC_I 16 69191061 _T2 CIRH1A 68.7 52.52 0.066 MHC_I 16 89337296 _T2 ANKRD11 393.1 30.62 0.444 MHC_I 17 7126528 _T2 ACADVL 9.6 223.5 0.21 MHC_I 17 7489372 _T2 MPDU1 8.3 38.46 0.103 MHC_I 17 7798765 _T2 CHD3 106.2 13.48 0.11 MHC_I 17 18781034 _T2 PRPSAP2 58.2 14.05 0.173 MHC_I 17 30226715 _T2 UTP6 6.7 26.21 0.174 MHC_I 17 38062171 _T2 GSDMB 66.9 19.48 0.071 MHC_I 17 40647674 _T2 ATP6V0A1 6.5 10.72 0.077 MHC_I 17 42429820 _T2 GRN 141.3 92.61 0.293 MHC_I

17 45750506 _T2 KPNB1 10.2 120.22 0.069 MHC_I 17 65353445 _T2 PSMD12 316.2 19.88 0.224 MHC_I 17 65907184 _T2 BPTF 204.9 14.4 0.184 MHC_I 18 28672130 _T2 DSC2 104.8 35.01 0.077 MHC_I 18 46808503 _T2 DYM 156.6 20.47 0.2 MHC_I 19 2123363 _T2 AP3D1 479.1 13.6 0.464 MHC_I 19 5896999 _T2 NDUFA11 87.3 68.3 0.369 MHC_I 19 12849356 _T2 ASNA1 174.2 26.25 0.25 MHC_I 19 38782575 _T2 SPINT2 26.8 209.19 0.081 MHC_I 19 39959402 _T2 SUPT5H 6.7 27.54 0.056 MHC_I 19 40741918 _T2 AKT2 27.2 12.16 0.055 MHC_I 2 26332761 _T2 RAB10 284.7 12.69 0.172 MHC_I 2 48025788 _T2 MSH6 95.4 30.88 0.062 MHC_I 2 96942849 _T2 SNRNP200 383.9 65.81 0.07 MHC_I 2 150426516 _T2 MMADHC 56 43.77 0.056 MHC_I 2 206997717 _T2 NDUFS1 426.5 40.48 0.105 MHC_I 2 223787440 _T2 ACSL3 141.5 11.2 0.081 MHC_I 22 44547427 _T2 PARVB 14 34.31 0.192 MHC_I 3 37045935 _T2 MLH1 162.1 35.66 0.395 MHC_I 3 49051303 _T2 WDR6 160.8 17.19 0.278 MHC_I 3 195508858 _T2 MUC4 46.2 107.8 0.115 MHC_I 4 56290737 _T2 TMEM165 142.5 12.5 0.358 MHC_I 4 76587136 _T2 G3BP2 18.1 37.56 0.163 MHC_I 4 151727449 _T2 LRBA 413.8 19.05 0.213 MHC_I 4 187629070 _T2 FAT1 16.7 58.64 0.186 MHC_I 5 14508359 _T2 TRIO 429.3 15.61 0.311 MHC_I 5 36995756 _T2 NIPBL 22.5 18.22 0.139 MHC_I 5 67589610 _T2 PIK3R1 118.6 11.92 0.144 MHC_I 6 117869454 _T2 DCBLD1 233.5 11.49 0.189 MHC_I 7 98552779 _T2 TRRAP 16.1 10.55 0.375 MHC_I 7 100635071 _T2 MUC12 32.1 263.93 0.083 MHC_I

8 48883248 _T2 MCM4 347.1 22 0.057 MHC_I 9 2119520 _T2 SMARCA2 145.8 16.53 0.053 MHC_I 9 34616038 _T2 DCTN3 172.5 18.53 0.136 MHC_I 9 79898557 _T2 VPS13A 4.7 36.23 0.079 MHC_I 9 131301957 _T2 GLE1 43.3 20.26 0.073 MHC_I 9 140137523 _T2 TUBB4B 45.1 592.62 0.173 MHC_I X 23724831 _T2 ACOT9 227.6 19.87 0.667 MHC_I X 70603863 _T2 TAF1 364.5 12.3 0.16 MHC_I 1 8716109 _T3 RERE 320 11.11 0.818 MHC_I 1 12378200 _T3 VPS13D 33.6 21.35 0.27 MHC_I 1 25573045 _T3 C1orf63 52.4 17.9 0.328 MHC_I 1 32852496 _T3 BSDC1 258.2 11.07 0.509 MHC_I 1 52704042 _T3 ZFYVE9 477.5 15.8 0.423 MHC_I 1 89279305 _T3 PKN2 150 25.89 0.429 MHC_I 1 97847999 _T3 DPYD 2.8 49.01 0.067 MHC_I 1 151318741 _T3 RFX5 53.7 21.85 0.852 MHC_I 1 202911182 _T3 ADIPOR1 45.9 11.55 0.103 MHC_I 1 225600231 _T3 LBR 54.4 22.13 0.108 MHC_I 10 27493433 _T3 ACBD5 27.8 38.81 0.506 MHC_I 10 97385138 _T3 ALDH18A1 24.6 32.56 0.091 MHC_I 10 104136818 _T3 GBF1 6 31.82 0.333 MHC_I 10 124922211 _T3 BUB3 4.1 56.06 0.412 MHC_I 11 429488 _T3 ANO9 138.1 22.82 1 MHC_I 11 1255051 _T3 MUC5B 113.9 386.77 0.277 MHC_I 11 1268355 _T3 MUC5B 11.8 386.77 0.109 MHC_I 11 17118740 _T3 PIK3C2A 278.8 13.23 0.362 MHC_I 11 57569589 _T3 CTNND1 35.1 35.88 0.183 MHC_I 11 64863791 _T3 VPS51 17.5 19.63 0.682 MHC_I 11 64897243 _T3 SYVN1 456.8 18.99 0.107 MHC_I 11 93428779 _T3 KIAA1731 8.3 18.18 0.127 MHC_I 11 104878041 _T3 CASP5 13 16.23 1 MHC_I

11 126137948 _T3 SRPR 45.1 28.06 0.105 MHC_I 12 7047705 _T3 ATN1 39.1 21.41 0.455 MHC_I 12 48533655 _T3 PFKM 18.6 20.13 0.37 MHC_I 12 57648750 _T3 R3HDM2 46.9 20.64 0.444 MHC_I 12 67699482 _T3 CAND1 14.5 14.41 0.211 MHC_I 13 73357634 _T3 PIBF1 27.7 25.57 0.416 MHC_I 13 103309437 _T3 TPP2 122.1 26.6 0.333 MHC_I 14 23549379 _T3 ACIN1 35 125.87 0.295 MHC_I 14 24033048 _T3 AP1G2 140.6 23.91 0.464 MHC_I 14 24644781 _T3 REC8 173.6 16.38 0.053 MHC_I 14 75248388 _T3 YLPM1 19.5 22.98 0.417 MHC_I 14 78036776 _T3 SPTLC2 44.4 15.49 0.435 MHC_I 14 100826907 _T3 WARS 342.4 53.72 0.074 MHC_I 14 102445788 _T3 DYNC1H1 6.6 122.21 0.122 MHC_I 15 40226481 _T3 EIF2AK4 482.2 20.28 0.465 MHC_I 15 42054541 _T3 MGA 4.3 23.17 0.342 MHC_I 15 70976680 _T3 UACA 30.2 17.33 0.071 MHC_I 16 15758700 _T3 NDE1 29 29.99 0.45 MHC_I 16 30435660 _T3 DCTPP1 451 20.2 0.086 MHC_I 16 46695735 _T3 VPS35 7.3 27.63 0.059 MHC_I 16 88798170 _T3 PIEZO1 8.2 37.29 0.139 MHC_I 16 89718047 _T3 CHMP1A 78.1 10.31 0.269 MHC_I 17 1581895 _T3 PRPF8 57.4 103.76 0.064 MHC_I 17 7402719 _T3 POLR2A 18.4 64.33 0.211 MHC_I 17 7804292 _T3 CHD3 130.4 40.73 0.282 MHC_I 17 34036252 _T3 AP2B1 71 29.3 0.135 MHC_I 17 38179525 _T3 MED24 8.7 13.71 0.261 MHC_I 17 40932962 _T3 WNK4 192.8 15.82 0.421 MHC_I 17 40936532 _T3 WNK4 23.3 15.82 0.474 MHC_I 17 41603872 _T3 DHX8 77.7 23.92 0.625 MHC_I 17 48460506 _T3 LRRC59 437.7 51.39 0.353 MHC_I

17 49067998 _T3 SPAG9 148.1 21.9 0.286 MHC_I 17 73518109 _T3 TSEN54 391.6 19.26 0.486 MHC_I 17 73566225 _T3 LLGL2 203 65.16 0.493 MHC_I 17 80049503 _T3 FASN 225.9 40.73 0.508 MHC_I 17 80195589 _T3 SLC16A3 175.7 17.32 0.195 MHC_I 18 39647473 _T3 PIK3C3 211.8 30.23 0.286 MHC_I 19 2132523 _T3 AP3D1 428.3 33.66 0.405 MHC_I 19 3982421 _T3 EEF2 133.9 276.46 0.355 MHC_I 19 7593075 _T3 MCOLN1 330 10.93 0.5 MHC_I 19 8609230 _T3 MYO1F 82.3 16.7 0.121 MHC_I 19 11098558 _T3 SMARCA4 32.9 89.28 0.306 MHC_I 19 11326559 _T3 DOCK6 13 12.67 0.172 MHC_I 19 11618364 _T3 ECSIT 3.1 11.85 0.348 MHC_I 19 12812612 _T3 TNPO2 153 11.33 0.416 MHC_I 19 21990979 _T3 ZNF43 468.8 15.26 0.714 MHC_I 19 38572578 _T3 SIPA1L3 88.5 10.94 0.467 MHC_I 19 40377134 _T3 FCGBP 93.9 1165.32 0.091 MHC_I 19 42409122 _T3 ARHGEF1 404.2 40.14 0.25 MHC_I 19 46278235 _T3 DMPK 24.6 13.1 0.15 MHC_I 19 54669235 _T3 TMC4 176 11.65 0.467 MHC_I 2 32706407 _T3 BIRC6 3.8 39.37 0.235 MHC_I 2 33813525 _T3 FAM98A 26.3 12.76 0.182 MHC_I 2 44145403 _T3 LRPPRC 46.7 58.23 0.376 MHC_I 2 46574154 _T3 EPAS1 91.3 21.65 0.12 MHC_I 2 54133991 _T3 PSME4 5.3 22.45 0.166 MHC_I 2 109087914 _T3 GCC2 218.5 41.24 0.315 MHC_I 2 152320541 _T3 RIF1 405.7 23.49 0.348 MHC_I 2 157369871 _T3 GPD2 7.2 14.1 0.326 MHC_I 2 170460581 _T3 PPIG 13.4 47.05 0.365 MHC_I 2 183829479 _T3 NCKAP1 38.9 31.75 0.183 MHC_I 2 233194613 _T3 DIS3L2 16.7 33.46 0.174 MHC_I

20 2819288 _T3 PCED1A 30.6 16.99 0.051 MHC_I 20 3891287 _T3 PANK2 98.9 28.14 0.39 MHC_I 20 16486373 _T3 KIF16B 334.9 17.61 0.542 MHC_I 20 44520930 _T3 CTSA 16.5 73.52 0.211 MHC_I 20 49196293 _T3 PTPN1 16.2 11.4 0.162 MHC_I 20 56139237 _T3 PCK1 98 14.43 0.548 MHC_I 21 34619186 _T3 IFNAR2 86.8 13.42 0.103 MHC_I 21 34775857 _T3 IFNGR2 88.6 31.07 0.226 MHC_I 21 38525560 _T3 TTC3 14 42.4 0.229 MHC_I 21 47662805 _T3 MCM3AP 15.2 25.06 0.179 MHC_I 22 42032631 _T3 XRCC6 94.9 143.05 0.873 MHC_I 22 44392231 _T3 SAMM50 176.2 17.54 0.5 MHC_I 3 25657052 _T3 TOP2B 30 41.4 0.102 MHC_I 3 41266137 _T3 CTNNB1 442.9 209.94 0.752 MHC_I 3 45153647 _T3 CDCP1 79.8 21.17 0.469 MHC_I 3 47165283 _T3 SETD2 19.4 41.9 0.152 MHC_I 3 48459616 _T3 PLXNB1 54.8 15.81 0.458 MHC_I 3 48664386 _T3 SLC26A6 47.3 35.08 0.413 MHC_I 3 51718549 _T3 TEX264 43.5 11.08 0.452 MHC_I 3 52682395 _T3 PBRM1 95.9 17.25 0.106 MHC_I 3 58062841 _T3 FLNB 182.5 56.12 0.491 MHC_I 3 69126954 _T3 UBA3 24.8 15.84 0.063 MHC_I 3 134251733 _T3 CEP63 28.2 17.67 0.221 MHC_I 4 3201572 _T3 HTT 183.2 20.81 0.351 MHC_I 4 40439875 _T3 RBM47 28.9 12.15 0.224 MHC_I 4 48852045 _T3 OCIAD1 37.9 17.83 0.259 MHC_I 4 83785565 _T3 SEC31A 30.6 28.36 0.104 MHC_I 4 146059717 _T3 OTUD4 21.3 13.01 0.528 MHC_I 4 166231859 _T3 KLHL2 15.5 15.63 0.224 MHC_I 5 889726 _T3 BRD9 81.1 44.22 0.052 MHC_I 5 5463351 _T3 KIAA0947 22.3 16.55 0.494 MHC_I

5 32404161 _T3 ZFR 25.7 18.13 0.211 MHC_I 5 36153056 _T3 SKP2 6.6 34.03 0.163 MHC_I 5 86672317 _T3 RASA1 289.4 21.95 0.5 MHC_I 5 96322302 _T3 LNPEP 127.6 18.91 0.174 MHC_I 5 102493987 _T3 PPIP5K2 380.3 15.96 0.489 MHC_I 5 145887465 _T3 TCERG1 148.5 71.6 0.173 MHC_I 5 157214668 _T3 CLINT1 38.2 39.64 0.057 MHC_I 6 25495373 _T3 LRRC16A 292.5 36.61 0.382 MHC_I 6 33273073 _T3 TAPBP 3.4 35.16 0.212 MHC_I 6 33384467 _T3 CUTA 45.9 30.71 0.07 MHC_I 6 41552550 _T3 FOXP4 28.8 11 0.276 MHC_I 6 88313235 _T3 ORC3 420.2 12.48 0.31 MHC_I 6 90432675 _T3 MDN1 148.4 20.22 0.444 MHC_I 6 128312479 _T3 PTPRK 123.4 23.48 0.552 MHC_I 6 131924228 _T3 MED23 214.3 16.61 0.297 MHC_I 7 1513920 _T3 INTS1 183.3 18.01 0.222 MHC_I 7 27187076 _T3 HOXA6 232.3 13.62 0.357 MHC_I 7 44664075 _T3 OGDH 82.5 41.52 0.231 MHC_I 7 65439343 _T3 GUSB 104.6 45.94 0.287 MHC_I 7 76134854 _T3 DTX2 24.7 31.88 0.488 MHC_I 7 91957188 _T3 ANKIB1 224.2 17.07 0.295 MHC_I 7 95750624 _T3 SLC25A13 382.3 16.68 0.333 MHC_I 7 97939854 _T3 BAIAP2L1 3.3 22.74 0.333 MHC_I 7 100867051 _T3 ZNHIT1 20.4 21.02 0.466 MHC_I 7 106924081 _T3 COG5 10.2 35.19 0.426 MHC_I 7 139829301 _T3 JHDM1D 57.2 16.49 0.443 MHC_I 7 140482927 _T3 BRAF 58.7 22.15 0.327 MHC_I 7 143078672 _T3 ZYX 98.1 25.8 0.321 MHC_I 8 23148931 _T3 R3HCC1 47.6 35.3 0.216 MHC_I 8 62475367 _T3 ASPH 2.9 44.96 0.323 MHC_I 8 68163617 _T3 ARFGEF1 89.3 22.72 0.072 MHC_I

8 120220743 _T3 MAL2 403.9 15.98 0.579 MHC_I 8 124384893 _T3 ATAD2 5.5 36.35 0.158 MHC_I 8 144943007 _T3 EPPK1 52.5 37.51 0.525 MHC_I 9 35801960 _T3 NPR2 39.6 11.2 0.412 MHC_I 9 99113417 _T3 SLC35D2 32.2 10.42 0.326 MHC_I 9 130929153 _T3 CIZ1 83.8 27.39 0.31 MHC_I 9 131222859 _T3 ODF2 71.9 57.23 0.386 MHC_I 9 132581100 _T3 TOR1A 46.3 14.86 0.457 MHC_I 9 140075271 _T3 ANAPC2 89.4 13.92 0.409 MHC_I X 47072566 _T3 UBA1 81.3 191.54 0.496 MHC_I X 57405179 _T3 FAAH2 320.4 15.19 1 MHC_I X 152960039 _T3 SLC6A8 18.4 14.72 0.127 MHC_I 1 14109058 FAP_G13 PRDM2 38.89 15.95 0.195 1 78207400 FAP_G13 USP33 243.71 40.93 0.063 1 166818356 FAP_G13 POGK 7.07 28.79 0.115 1 185089552 FAP_G13 TRMT1L 29.14 13.52 0.062 10 105495507 FAP_G13 SH3PXD2A 41.2 26.72 0.075 10 114917781 FAP_G13 TCF7L2 197.45 31.06 0.385 10 126451032 FAP_G13 METTL10 15.21 11.28 0.156 11 18359735 FAP_G13 GTF2H1 154.13 26.13 0.083 11 33106641 FAP_G13 CSTF3 204.86 33.78 0.062 11 46703602 FAP_G13 ARHGAP1 41.42 50.23 0.081 12 6672818 FAP_G13 NOP2 210.57 22.13 0.051 12 21626520 FAP_G13 RECQL 416.67 16.91 0.096 12 48084336 FAP_G13 RPAP3 19.38 17.27 0.099 12 59281595 FAP_G13 LRIG3 3.78 25.92 0.057 12 109522775 FAP_G13 USP30 73.78 14.55 0.111 13 24411739 FAP_G13 MIPEP 25.03 30.56 0.07 13 37619398 FAP_G13 SUPT20H 307.64 23.24 0.088 14 24459558 FAP_G13 DHRS4L2 119.58 41.19 0.076 14 24878811 FAP_G13 NYNRIN 34.28 14.77 0.2

14 31637582 FAP_G13 HECTD1 12.83 37.33 0.061 14 31814322 FAP_G13 HEATR5A 33.6 13.62 0.103 14 90397941 FAP_G13 EFCAB11 36.67 17.84 0.125 15 25620790 FAP_G13 UBE3A 3.55 33.77 0.058 15 28474843 FAP_G13 HERC2 104.1 12.08 0.3 15 89836004 FAP_G13 FANCI 147.48 18.56 0.056 16 53260373 FAP_G13 CHD9 174.7 12.97 0.316 16 84600531 FAP_G13 COTL1 16.85 62.39 0.062 17 15978875 FAP_G13 NCOR1 56.42 35.98 0.052 17 16052812 FAP_G13 NCOR1 28.71 35.98 0.284 17 73515123 FAP_G13 TSEN54 26.38 28.04 0.105 18 44426713 FAP_G13 PIAS2 20.11 17.68 0.057 19 15378305 FAP_G13 BRD4 196.32 16.67 0.084 2 18736845 FAP_G13 RDH14 239.44 28.11 0.07 2 27601679 FAP_G13 ZNF513 19.9 20.73 0.097 2 88892839 FAP_G13 EIF2AK3 34.72 21.62 0.2 2 203420129 FAP_G13 BMPR2 135.16 11.76 0.125 2 203420129 FAP_G13 BMPR2 135.16 11.76 0.088 2 203420129 FAP_G13 BMPR2 130.09 11.76 0.125 2 203420129 FAP_G13 BMPR2 130.09 11.76 0.088 22 43253147 FAP_G13 ARFGAP3 4.06 41.63 0.136 3 97686274 FAP_G13 MINA 71.31 13.28 0.069 3 193382704 FAP_G13 OPA1 38.66 40.16 0.09 3 194146150 FAP_G13 ATP13A3 8.49 38.68 0.078 4 42445639 FAP_G13 ATP8A1 40.94 32.05 0.083 4 110454749 FAP_G13 SEC24B 36.4 25.94 0.106 4 169195168 FAP_G13 DDX60 96.08 13.86 0.091 5 40798239 FAP_G13 PRKAA1 49.18 46.73 0.236 5 55237518 FAP_G13 IL6ST 284.27 25.11 0.055 5 87501638 FAP_G13 TMEM161B 14.06 18.72 0.133 5 180374756 FAP_G13 BTNL8 58.19 35.07 0.182

6 106967244 FAP_G13 AIM1 82.38 42.29 0.078 6 110530369 FAP_G13 CDC40 251.98 23.12 0.13 7 11030370 FAP_G13 PHF14 462.35 25.94 0.145 7 38812211 FAP_G13 VPS41 112.42 27.08 0.091 7 50514060 FAP_G13 FIGNL1 63.47 10.89 0.257 7 89856719 FAP_G13 STEAP2 7.38 12.33 0.25 7 100029007 FAP_G13 MEPCE 27.13 33.76 0.354 7 108155329 FAP_G13 PNPLA8 8.59 17.9 0.075 8 41806778 FAP_G13 KAT6A 118.64 11.77 0.167 8 57224787 FAP_G13 SDR16C5 36.64 12.66 0.051 8 90993682 FAP_G13 NBN 185.84 32.04 0.07 8 104336991 FAP_G13 FZD6 426.49 22.3 0.107 9 94171750 FAP_G13 NFIL3 458.76 19.71 0.063 X 48933235 FAP_G13 WDR45 363.43 36.36 0.589 X 153649069 FAP_G13 TAZ 116.09 18.17 0.097 1 113232137 FAP_G14 MOV10 242.1 25.63 0.067 1 200017380 FAP_G14 NR5A2 88.16 20.44 0.169 1 204399080 FAP_G14 PIK3C2B 10.61 27.52 0.073 1 247014141 FAP_G14 AHCTF1 51.59 13.29 0.068 10 53458999 FAP_G14 CSTF2T 254.35 19.72 0.067 10 69565516 FAP_G14 DNAJC12 264.18 51.08 0.078 10 97916170 FAP_G14 ZNF518A 358.18 17.03 0.152 10 112661364 FAP_G14 BBIP1 37.9 12.76 0.136 10 114911552 FAP_G14 TCF7L2 8.84 34.08 0.174 11 16892700 FAP_G14 PLEKHA7 252.68 14.5 0.115 11 45935395 FAP_G14 PEX16 8.61 21.15 0.064 11 47376999 FAP_G14 SPI1 328.92 13.97 0.075 11 64597015 FAP_G14 CDC42BPG 25.73 18.07 0.07 11 71148862 FAP_G14 DHCR7 15.72 25.73 0.098 11 111915865 FAP_G14 DLAT 12.21 31.41 0.059 12 57553691 FAP_G14 LRP1 127.57 39.52 0.057

12 57553693 FAP_G14 LRP1 38.31 39.52 0.057 12 117583969 FAP_G14 FBXO21 178.8 27.69 0.054 14 35262064 FAP_G14 BAZ1A 69.2 20.46 0.235 14 50933311 FAP_G14 MAP4K5 258.29 22.13 0.093 14 74345900 FAP_G14 PTGR2 73.78 17.5 0.135 15 25584316 FAP_G14 UBE3A 29.85 35.9 0.098 15 30011997 FAP_G14 TJP1 98.63 22.67 0.083 15 34527447 FAP_G14 SLC12A6 30.59 13.77 0.1 15 52524825 FAP_G14 MYO5C 21.5 32.53 0.067 15 63918192 FAP_G14 HERC1 58.12 10.35 0.068 15 66729114 FAP_G14 MAP2K1 20.1 37.36 0.111 15 82533696 FAP_G14 EFTUD1 36.46 32.27 0.069 16 10850578 FAP_G14 NUBP1 17.77 37.6 0.052 16 50134245 FAP_G14 HEATR3 18.9 16.5 0.256 17 34866606 FAP_G14 MYO19 31.27 22.81 0.06 17 36966833 FAP_G14 CWC25 59.58 16.02 0.273 17 48423632 FAP_G14 XYLT2 302.54 29.8 0.074 18 9211730 FAP_G14 ANKRD12 75.07 12.4 0.115 18 9557253 FAP_G14 PPP4R1 66.82 35.17 0.073 19 5832557 FAP_G14 FUT6 144.37 32.93 0.051 19 10662968 FAP_G14 ATG4D 13.83 21.75 0.099 2 54115918 FAP_G14 PSME4 14.06 21.23 0.066 2 73996405 FAP_G14 DUSP11 31.84 29.42 0.072 20 62195118 FAP_G14 HELZ2 17.88 10.53 0.12 3 97686274 FAP_G14 MINA 71.31 15.39 0.091 3 101383533 FAP_G14 ZBTB11 52.11 12.47 0.115 3 123451781 FAP_G14 MYLK 187.43 37.07 0.15 3 182575785 FAP_G14 ATP11B 473.81 44.71 0.098 3 193382704 FAP_G14 OPA1 38.66 36.44 0.105 5 55237518 FAP_G14 IL6ST 284.27 29.05 0.056 5 87521593 FAP_G14 TMEM161B 127.73 18.6 0.114

6 82459438 FAP_G14 FAM46A 246.98 20.98 0.115 6 99347304 FAP_G14 FBXL4 26.09 14.68 0.073 7 89856719 FAP_G14 STEAP2 7.38 11.82 0.227 7 91503179 FAP_G14 MTERF 9.62 11.64 0.1 8 90993682 FAP_G14 NBN 185.84 27.41 0.063 8 144808528 FAP_G14 FAM83H 24.42 30.45 0.057 1 9305562 FAP_G15 H6PD 239.44 34.89 0.067 1 78187733 FAP_G15 USP33 26.8 41.87 0.051 1 150970159 FAP_G15 FAM63A 163.87 27.83 0.067 10 103432680 FAP_G15 FBXW4 24.18 52.22 0.052 11 232991 FAP_G15 SIRT3 20.43 17.71 0.08 11 14882799 FAP_G15 PDE3B 387.89 19.52 0.408 11 121475905 FAP_G15 SORL1 52.04 68.69 0.129 12 1702238 FAP_G15 FBXL14 11.07 24.29 0.057 12 57135291 FAP_G15 PRIM1 105.19 16.46 0.171 12 88436652 FAP_G15 C12orf29 141.06 13.53 0.077 12 100502184 FAP_G15 UHRF1BP1L 108.15 10.2 0.238 12 102159871 FAP_G15 GNPTAB 98.37 61.1 0.054 12 118814506 FAP_G15 SUDS3 51.81 37.27 0.087 13 31725288 FAP_G15 HSPH1 330.81 44.27 0.08 14 23598945 FAP_G15 SLC7A8 35.35 53.34 0.055 14 92253887 FAP_G15 TC2N 7.54 53.54 0.065 16 14711479 FAP_G15 PARN 26.36 31.53 0.081 16 18569061 FAP_G15 NOMO2 80.86 50.77 0.2 16 23546280 FAP_G15 EARS2 178.22 19.75 0.525 16 57269044 FAP_G15 RSPRY1 13.29 30.37 0.111 17 2139867 FAP_G15 SMG6 9.37 15.08 0.082 19 11453495 FAP_G15 TMEM205 42.45 98.76 0.12 19 12856300 FAP_G15 ASNA1 21.69 89.15 0.107 19 35174128 FAP_G15 ZNF302 71.19 25.12 0.122 2 11389837 FAP_G15 ROCK2 49.77 63.26 0.143

2 229890569 FAP_G15 PID1 246.43 43.38 0.064 2 230668773 FAP_G15 TRIP12 26.62 49.34 0.513 2 242157717 FAP_G15 ANO7 35.26 34.7 0.053 3 63981867 FAP_G15 ATXN7 39.52 11.12 0.143 3 97686274 FAP_G15 MINA 71.31 15.12 0.088 3 100091451 FAP_G15 TOMM70A 24.89 60.81 0.082 3 126178529 FAP_G15 ZXDC 27.82 15.66 0.114 3 139346515 FAP_G15 NMNAT3 12.56 11.64 0.143 3 145799525 FAP_G15 PLOD2 70.12 48.11 0.081 3 184922464 FAP_G15 EHHADH 53.8 28.73 0.063 4 110454749 FAP_G15 SEC24B 36.4 28.84 0.173 4 129028341 FAP_G15 LARP1B 233.59 23.45 0.157 4 153864507 FAP_G15 FHDC1 49.05 17.1 0.409 5 36117881 FAP_G15 LMBRD2 9.73 13.94 0.107 5 52161600 FAP_G15 ITGA1 231.8 12.31 0.222 5 54555685 FAP_G15 DHX29 78.7 20.19 0.081 5 55237518 FAP_G15 IL6ST 284.27 22.74 0.059 5 72858434 FAP_G15 ANKRA2 16.85 32.07 0.053 6 33289004 FAP_G15 DAXX 42.06 38.14 0.059 6 33289005 FAP_G15 DAXX 41.9 38.14 0.059 6 41877149 FAP_G15 MED20 27.3 21.61 0.068 6 83891512 FAP_G15 PGM3 93.88 29.17 0.054 6 106967244 FAP_G15 AIM1 82.38 47.85 0.091 6 110530369 FAP_G15 CDC40 251.98 24.98 0.159 6 139264691 FAP_G15 REPS1 20.15 26.94 0.125 6 149916207 FAP_G15 KATNA1 286.41 16.21 0.078 7 94164724 FAP_G15 CASD1 49.79 27.21 0.061 7 138210057 FAP_G15 TRIM24 62.16 23.25 0.171 8 30469841 FAP_G15 GTF2E2 218.92 38.84 0.052 9 18143 FAP_G15 WASH1 62.64 13.99 0.667 9 26886129 FAP_G15 CAAP1 162.99 37.85 0.058

9 33469518 FAP_G15 NOL6 15.66 14.05 0.064 9 140247215 FAP_G15 EXD3 5.78 10.59 0.333 X 74293781 FAP_G15 ABCB7 4.49 29.81 0.098 X 119005930 FAP_G15 NDUFA1 3.84 630.54 0.261 X 129290502 FAP_G15 AIFM1 48.49 67.64 0.052 1 35321023 FAP_G2 SMIM12 82.42 15.42 0.06 1 54675779 FAP_G2 MRPL37 77.87 118.46 0.472 1 68948427 FAP_G2 DEPDC1 128 10.25 0.258 1 91405165 FAP_G2 ZNF644 52.8 30.02 0.079 1 163318806 FAP_G2 NUF2 349.64 14.53 0.111 1 229601235 FAP_G2 NUP133 25.9 25.53 0.068 1 247014141 FAP_G2 AHCTF1 51.59 12.41 0.077 10 79397185 FAP_G2 KCNMA1 157.48 13.34 0.079 10 86130816 FAP_G2 CCSER2 35.78 15.28 0.143 10 123721542 FAP_G2 NSMCE4A 93.5 66.2 0.294 12 27183115 FAP_G2 MED21 198.73 30.94 0.135 12 57466593 FAP_G2 TMEM194A 98.01 10.58 0.094 12 64828647 FAP_G2 XPOT 8.02 35.35 0.055 12 69127236 FAP_G2 NUP107 10.8 29.78 0.197 12 109921682 FAP_G2 UBE3B 10.03 22.01 0.054 13 26956961 FAP_G2 CDK8 48.64 22.23 0.344 14 23420864 FAP_G2 HAUS4 8.16 58.19 0.529 14 36018352 FAP_G2 RALGAPA1 10.65 18.59 0.143 14 93730184 FAP_G2 BTBD7 32.37 19.33 0.137 15 62256915 FAP_G2 VPS13C 30.7 21.81 0.095 16 4924668 FAP_G2 UBN1 6.91 20.31 0.075 16 18896453 FAP_G2 SMG1 234.51 29.03 0.121 16 22343403 FAP_G2 POLR3E 14.65 22.59 0.088 16 67654615 FAP_G2 CTCF 78.71 36.96 0.392 16 67765377 FAP_G2 RANBP10 226.58 16.07 0.125 17 2371076 FAP_G2 METTL16 23.09 10.86 0.24

17 70120292 FAP_G2 SOX9 192.53 108.13 0.084 18 46904984 FAP_G2 DYM 32.11 25.2 0.082 19 51537237 FAP_G2 KLK12 18.34 46.81 0.059 2 100020923 FAP_G2 REV1 29.54 21.71 0.053 2 152316604 FAP_G2 RIF1 95.8 11.56 0.25 2 153004779 FAP_G2 STAM2 39.48 19.03 0.065 2 200137130 FAP_G2 SATB2 29.91 47.34 0.057 20 2816762 FAP_G2 PCED1A 151.17 23.16 0.224 20 5559030 FAP_G2 GPCPD1 323.57 27.63 0.107 3 33626305 FAP_G2 CLASP2 35.13 13.32 0.075 3 33650077 FAP_G2 CLASP2 28.04 13.32 0.115 3 42602714 FAP_G2 SEC22C 47.03 18.05 0.132 3 81720070 FAP_G2 GBE1 23.63 18.15 0.119 4 22415377 FAP_G2 GPR125 8.33 41.27 0.052 4 49030709 FAP_G2 CWH43 174.77 25.45 0.08 4 129099754 FAP_G2 LARP1B 345.79 21.03 0.385 5 94872769 FAP_G2 TTC37 10.15 40.26 0.053 5 132161715 FAP_G2 SHROOM1 27.43 42.76 0.056 5 148904673 FAP_G2 CSNK1A1 14.49 146.13 0.51 5 162911199 FAP_G2 HMMR 21.68 23.16 0.071 6 111310240 FAP_G2 RPF2 39.98 45.73 0.115 6 157521938 FAP_G2 ARID1B 62.54 16.9 0.059 7 99506230 FAP_G2 TRIM4 48.49 19.96 0.064 7 156589160 FAP_G2 LMBR1 9.8 21.28 0.169 8 38645095 FAP_G2 TACC1 50.81 41.97 0.118 8 98656927 FAP_G2 MTDH 22.72 42.57 0.053 8 145745966 FAP_G2 LRRC14 30.69 12.77 0.167 9 95064054 FAP_G2 NOL8 52.44 22.11 0.053 X 100297083 FAP_G2 TRMT2B 162.27 21.28 0.078 X 100880075 FAP_G2 ARMCX3 12.67 46.16 0.075 X 148582538 FAP_G2 IDS 343.21 28.43 0.223

1 39377044 FAP_G25 RHBDL2 23.43 43.83 0.056 1 45110738 FAP_G25 RNF220 181.83 24.37 0.063 1 91403063 FAP_G25 ZNF644 24.11 33.2 0.158 10 27497188 FAP_G25 ACBD5 16.37 18.5 0.081 11 64534502 FAP_G25 SF1 110.4 49.1 0.055 12 51385382 FAP_G25 SLC11A2 9.6 15.23 0.136 15 49429376 FAP_G25 COPS2 71.32 32.4 0.091 15 55526991 FAP_G25 RAB27A 85.68 39.35 0.069 15 83208738 FAP_G25 RPS17L 18.73 3787.42 0.115 15 91485796 FAP_G25 UNC45A 235.81 17.98 0.125 16 67477072 FAP_G25 ATP6V0D1 24.08 89.15 0.093 17 79077889 FAP_G25 BAIAP2 282.09 10.15 0.22 18 29125877 FAP_G25 DSG2 25.9 59.37 0.137 19 45281268 FAP_G25 CBLC 62.79 39.82 0.103 2 65480928 FAP_G25 ACTR2 58.73 72.64 0.065 2 148705769 FAP_G25 ORC4 171.11 20.62 0.135 2 160628445 FAP_G25 CD302 58.12 14.27 0.122 2 166615346 FAP_G25 GALNT3 292.19 46.85 0.079 3 125725303 FAP_G25 SLC41A3 33.19 16.44 0.063 3 136664927 FAP_G25 NCK1 19.4 31.44 0.06 4 159606334 FAP_G25 ETFDH 167.23 18.36 0.073 5 96512898 FAP_G25 RIOK2 40.28 13.3 0.073 5 138386631 FAP_G25 SIL1 342.03 40.81 0.057 5 141248154 FAP_G25 PCDH1 239.37 15.19 0.214 6 31112664 FAP_G25 CCHCR1 109.23 22.03 0.062 6 106696039 FAP_G25 ATG5 12.36 33.66 0.055 1 87026013 FAP_G29 CLCA4 127.04 148.2 0.079 10 88197701 FAP_G29 WAPAL 313.67 10.33 0.077 10 95454638 FAP_G29 FRA10AC1 39.13 12.02 0.105 12 27110626 FAP_G29 FGFR1OP2 16.18 19.51 0.057 14 92251705 FAP_G29 TC2N 144.97 28.55 0.164

15 44055275 FAP_G29 PDIA3 105.26 395.96 0.061 17 28819761 FAP_G29 GOSR1 369.15 18.08 0.318 2 187365006 FAP_G29 ZC3H15 307.2 65.89 0.116 22 46098591 FAP_G29 ATXN10 364.95 40.9 0.115 3 136664927 FAP_G29 NCK1 163.97 23.2 0.099 3 180328073 FAP_G29 TTC14 50.2 15.5 0.171 4 103189225 FAP_G29 SLC39A8 77.15 67.39 0.189 4 146044645 FAP_G29 ABCE1 56.01 20.92 0.146 5 54675005 FAP_G29 SKIV2L2 114.4 20.64 0.167 5 179046273 FAP_G29 HNRNPH1 32.17 247.53 0.054 6 76412560 FAP_G29 SENP6 68.65 12.43 0.135 X 101408997 FAP_G29 BEX5 27.52 14.31 0.062 1 35480655 FAP_G3 ZMYM6 441.75 14.27 0.186 1 43829648 FAP_G3 ELOVL1 89.84 102.59 0.316 1 51048344 FAP_G3 FAF1 13.39 28.76 0.13 1 154523916 FAP_G3 UBE2Q1 10.88 45.07 0.241 1 180010325 FAP_G3 CEP350 30.32 10.02 0.176 11 65337966 FAP_G3 SSSCA1 437.68 49.71 0.343 11 68367959 FAP_G3 PPP6R3 66.01 42.02 0.075 14 20852771 FAP_G3 TEP1 46.42 15 0.231 14 36018352 FAP_G3 RALGAPA1 10.65 16.13 0.222 14 74179453 FAP_G3 PNMA1 163.95 13.63 0.083 14 92471831 FAP_G3 TRIP11 391.22 11.94 0.12 14 93760617 FAP_G3 BTBD7 33.68 14.94 0.13 15 40854986 FAP_G3 C15orf57 229.94 31.43 0.058 15 51028847 FAP_G3 SPPL2A 46.98 41.25 0.063 15 64066970 FAP_G3 HERC1 151.98 10.49 0.176 15 64747205 FAP_G3 TRIP4 72.69 28.17 0.058 17 5456709 FAP_G3 NLRP1 62.76 14.62 0.115 17 7466865 FAP_G3 SENP3 53.35 32.92 0.345 18 21523784 FAP_G3 LAMA3 48.1 12.24 0.514

18 32825609 FAP_G3 ZNF397 139.01 22.24 0.075 18 32920554 FAP_G3 ZNF24 481.1 32.46 0.057 19 55559835 FAP_G3 RDH13 10.12 20.65 0.075 3 43641915 FAP_G3 ANO10 138.45 23.31 0.07 3 113627925 FAP_G3 GRAMD1C 85.79 10.49 0.188 3 133666227 FAP_G3 SLCO2A1 6.44 27.34 0.059 5 139903713 FAP_G3 ANKHD1 22.56 31.09 0.137 5 139903713 FAP_G3 ANKHD1-22.56 14.92 0.137 EIF4EBP3 6 170880560 FAP_G3 TBP 2.61 18.57 0.057 8 38123661 FAP_G3 PPAPDC1B 71.45 82.58 0.051 9 8341758 FAP_G3 PTPRD 107.96 28.7 0.053 9 86617646 FAP_G3 RMI1 132.29 11.44 0.362 X 100630169 FAP_G3 BTK 13.8 15.11 0.13 11 43350325 FAP_G39 API5 168.45 38.09 0.053 11 65655423 FAP_G39 FIBP 21.66 40.14 0.069 12 29496096 FAP_G39 ERGIC2 101.04 41.83 0.089 14 35050806 FAP_G39 SNX6 141.23 65.27 0.067 15 59961170 FAP_G39 BNIP2 111.17 17.6 0.103 16 15091639 FAP_G39 PDXDC1 50.42 81.94 0.085 16 89960161 FAP_G39 TCF25 93.27 63.79 0.107 17 38243083 FAP_G39 THRA 65.96 18.51 0.096 19 18391846 FAP_G39 JUND 14.34 62.94 0.053 2 183703146 FAP_G39 FRZB 207.48 19.01 0.06 2 191161637 FAP_G39 HIBCH 335.21 78.7 0.065 2 223489444 FAP_G39 FARSB 475.17 39.33 0.094 22 23915577 FAP_G39 IGLL1 27.88 211.7 0.333 3 58302694 FAP_G39 RPP14 66.18 16.42 0.108 3 129155643 FAP_G39 MBD4 307.36 20.43 0.175 3 193382704 FAP_G39 OPA1 36.82 19.71 0.094 3 195250490 FAP_G39 PPP1R2 376.33 31.13 0.053 5 64100142 FAP_G39 CWC27 187.77 19.15 0.125

5 171638950 FAP_G39 UBTD2 447.28 13.4 0.233 6 160196216 FAP_G39 ACAT2 199.73 56.1 0.131 8 24250842 FAP_G39 ADAMDEC1 161.3 124.35 0.08 X 70516490 FAP_G39 NONO 102.2 89.47 0.067 1 29365810 FAP_G47 EPB41 67.65 20.93 0.067 1 47173603 FAP_G47 EFCAB14 136.11 38.21 0.061 1 85397050 FAP_G47 MCOLN2 175.41 13.43 0.12 1 146672923 FAP_G47 FMO5 232.21 22.88 0.075 10 93021137 FAP_G47 PCGF5 11.67 76.48 0.121 10 105344440 FAP_G47 NEURL 322.22 12.1 0.5 11 58384775 FAP_G47 ZFP91 475.62 33.5 0.104 11 82880952 FAP_G47 PCF11 237.77 19.52 0.178 12 21661479 FAP_G47 GOLT1B 121.36 34.61 0.068 12 44148162 FAP_G47 PUS7L 56.16 14.61 0.075 12 69650513 FAP_G47 CPSF6 98.65 25.35 0.167 13 75876414 FAP_G47 TBC1D4 168.95 11.29 0.073 14 55643819 FAP_G47 DLGAP5 330.46 22.26 0.161 14 72128104 FAP_G47 SIPA1L1 170.94 12.29 0.185 14 104026258 FAP_G47 BAG5 197.93 15.28 0.087 15 59406800 FAP_G47 CCNB2 108.21 38.36 0.063 16 50120248 FAP_G47 HEATR3 167.01 22.17 0.101 16 58608633 FAP_G47 CNOT1 129.54 29.13 0.143 16 67477072 FAP_G47 ATP6V0D1 56.73 59.57 0.224 17 29226335 FAP_G47 TEFM 83.79 34.94 0.057 18 260212 FAP_G47 THOC1 40.37 26.78 0.074 18 19283545 FAP_G47 ABHD3 92.33 70.39 0.053 18 33691076 FAP_G47 SLC39A6 116.41 17.03 0.061 2 37487371 FAP_G47 PRKD3 6.93 13.93 0.091 2 70315174 FAP_G47 PCBP1 164.78 170.51 0.056 2 71592563 FAP_G47 ZNF638 107.47 38.18 0.17 2 95787497 FAP_G47 MRPS5 142.05 55.5 0.053

2 148715877 FAP_G47 ORC4 249.11 37.31 0.051 2 159488390 FAP_G47 PKP4 208.45 21.12 0.057 20 5560674 FAP_G47 GPCPD1 43.63 37.79 0.098 3 88205388 FAP_G47 C3orf38 23.86 26.37 0.052 3 170108207 FAP_G47 SKIL 80.73 32.27 0.055 4 77065549 FAP_G47 NUP54 82.42 48.53 0.056 4 114378536 FAP_G47 CAMK2D 339.44 26.59 0.056 4 128814503 FAP_G47 PLK4 137.55 12.41 0.086 5 41934329 FAP_G47 FBXO4 431.99 23.58 0.061 5 54645466 FAP_G47 SKIV2L2 297.27 45.99 0.092 5 114860048 FAP_G47 FEM1C 30.04 17.96 0.063 7 86826041 FAP_G47 TMEM243 139.06 41.75 0.051 7 112424712 FAP_G47 TMEM168 35.23 39.57 0.052 7 156589130 FAP_G47 LMBR1 181.16 16 0.079 9 130331099 FAP_G47 FAM129B 104.28 70.06 0.051 X 129270623 FAP_G47 AIFM1 107.8 39.2 0.075 1 47024412 FAP_G48 MKNK1 41.95 12.28 0.07 1 47024413 FAP_G48 MKNK1 42.83 12.28 0.07 1 51005336 FAP_G48 FAF1 84.89 14 0.167 10 32576151 FAP_G48 EPC1 39.31 19.73 0.055 11 2950399 FAP_G48 PHLDA2 191.88 23.01 0.051 11 58384775 FAP_G48 ZFP91 475.62 32.27 0.139 11 82880952 FAP_G48 PCF11 237.77 17.95 0.2 11 114578178 FAP_G48 NXPE2 134.48 18.1 0.154 12 6729762 FAP_G48 LPAR5 101.23 13.8 0.081 12 10783652 FAP_G48 STYK1 23.42 15.56 0.111 12 69650513 FAP_G48 CPSF6 98.65 21.85 0.111 12 105589066 FAP_G48 APPL2 93.9 33.1 0.075 12 122825968 FAP_G48 CLIP1 88.79 11.02 0.083 12 133353236 FAP_G48 GOLGA3 392.76 14 0.051 14 31917387 FAP_G48 DTD2 303.82 17.27 0.051

15 35274372 FAP_G48 ZNF770 253.21 17.88 0.087 16 2263739 FAP_G48 PGP 227.21 13.27 0.074 16 15978045 FAP_G48 FOPNL 16.98 41.95 0.06 16 46695692 FAP_G48 VPS35 22.97 74.72 0.052 16 50120248 FAP_G48 HEATR3 167.01 21.89 0.117 16 58608633 FAP_G48 CNOT1 129.54 27.16 0.077 16 67477072 FAP_G48 ATP6V0D1 56.73 78.5 0.101 16 68267962 FAP_G48 ESRP2 213.97 39.35 0.06 17 38567938 FAP_G48 TOP2A 110.35 23.53 0.073 17 67260965 FAP_G48 ABCA5 102.32 15.75 0.055 18 260212 FAP_G48 THOC1 40.37 21.34 0.1 18 59757761 FAP_G48 PIGN 325.2 20.76 0.068 19 4054669 FAP_G48 ZBTB7A 10.79 21.11 0.086 19 9525024 FAP_G48 ZNF266 120.5 14.37 0.068 19 33984213 FAP_G48 PEPD 52.01 32.07 0.058 2 20455795 FAP_G48 PUM2 50.38 40.94 0.062 2 47403651 FAP_G48 CALM2 11.94 1934.99 0.25 2 74688604 FAP_G48 MOGS 38.8 27.5 0.052 2 100011002 FAP_G48 EIF5B 355.37 21.04 0.114 2 148715877 FAP_G48 ORC4 249.11 36.37 0.08 2 176857119 FAP_G48 KIAA1715 67.73 10.58 0.118 20 5560674 FAP_G48 GPCPD1 43.63 25.26 0.069 21 34132173 FAP_G48 PAXBP1 217.33 22.77 0.119 21 34892778 FAP_G48 GART 161.83 31.86 0.093 4 99808294 FAP_G48 EIF4E 90.95 64.03 0.063 7 92085807 FAP_G48 GATAD1 174.01 17.58 0.061 9 95992134 FAP_G48 WNK2 19.26 12.89 0.125 1 21220014 FAP_G5 EIF4G3 151.42 34.36 0.082 1 35919168 FAP_G5 KIAA0319L 51.93 38.26 0.082 1 52280223 FAP_G5 NRD1 295.52 70.68 0.091 1 154229586 FAP_G5 UBAP2L 31.94 50.77 0.067

1 201983065 FAP_G5 ELF3 26.84 448.41 0.393 10 47919971 FAP_G5 FAM21B 29.04 18.08 0.107 10 75299276 FAP_G5 USP54 69.66 33.91 0.056 11 43465666 FAP_G5 TTC17 263.56 35.65 0.097 11 60670256 FAP_G5 PRPF19 77.53 118.1 0.405 12 30789957 FAP_G5 IPO8 230.75 35.91 0.051 12 50482355 FAP_G5 SMARCD1 103.65 28.35 0.108 12 62798030 FAP_G5 USP15 289.35 19.95 0.155 12 65141513 FAP_G5 GNS 220.56 53.32 0.115 12 107371383 FAP_G5 MTERFD3 85.19 19.53 0.292 12 110451041 FAP_G5 ANKRD13A 174.57 25.09 0.11 12 124104224 FAP_G5 DDX55 271.15 18.19 0.476 14 32561020 FAP_G5 ARHGAP5 188.41 28.35 0.132 14 50074402 FAP_G5 LRR1 226.46 28.08 0.15 14 55817786 FAP_G5 FBXO34 21.82 59.19 0.06 15 31233717 FAP_G5 MTMR10 50.78 20.23 0.085 15 41046816 FAP_G5 RMDN3 473.65 40.05 0.06 15 64669047 FAP_G5 KIAA0101 271.81 22.14 0.061 16 1498438 FAP_G5 CLCN7 233.91 18.96 0.073 16 67943066 FAP_G5 PSKH1 369.73 29.78 0.053 16 72138457 FAP_G5 DHX38 267.95 32.13 0.129 17 12853004 FAP_G5 ARHGAP44 60.08 27.83 0.405 17 27438740 FAP_G5 MYO18A 70.5 35.03 0.196 17 40870508 FAP_G5 EZH1 88.06 15.82 0.188 17 62528008 FAP_G5 CEP95 226.26 19.18 0.147 18 18539865 FAP_G5 ROCK1 23.84 21.97 0.164 18 72913415 FAP_G5 ZADH2 247.85 25.12 0.065 19 804596 FAP_G5 PTBP1 37.78 152.43 0.336 19 10257082 FAP_G5 DNMT1 25.73 23.23 0.093 2 11356307 FAP_G5 ROCK2 433.54 64.11 0.107 2 39213243 FAP_G5 SOS1 251.79 14.79 0.18

2 54122754 FAP_G5 PSME4 331.5 30.28 0.078 2 61441220 FAP_G5 USP34 130.87 22.81 0.268 2 113331215 FAP_G5 POLR1B 295.26 22.01 0.14 2 174228145 FAP_G5 CDCA7 166.03 87.71 0.082 2 191161637 FAP_G5 HIBCH 490.12 37.95 0.052 2 231307748 FAP_G5 SP100 353.99 38.38 0.1 20 9318697 FAP_G5 PLCB4 105.97 74.35 0.053 21 34110493 FAP_G5 PAXBP1 64.5 25.96 0.068 3 9412837 FAP_G5 THUMPD3 47.74 31.51 0.091 3 38263085 FAP_G5 OXSR1 391.59 32.08 0.111 3 47719691 FAP_G5 SMARCC1 138.02 51.58 0.057 3 49200321 FAP_G5 CCDC71 88.91 19.01 0.064 3 56702472 FAP_G5 FAM208A 26.54 22.72 0.065 3 101383533 FAP_G5 ZBTB11 224.73 15.67 0.143 3 107798852 FAP_G5 CD47 94.27 39.38 0.065 3 122437236 FAP_G5 PARP14 418.89 21.79 0.164 3 160148986 FAP_G5 SMC4 104 31.42 0.065 3 182810260 FAP_G5 MCCC1 317.81 36.17 0.108 4 56724578 FAP_G5 EXOC1 176.12 47.24 0.053 4 90035281 FAP_G5 TIGD2 199.99 11.44 0.222 4 102117109 FAP_G5 PPP3CA 105.62 37.53 0.053 4 107133947 FAP_G5 TBCK 92.85 16.35 0.116 4 159816976 FAP_G5 FNIP2 469.6 20.14 0.063 5 60053357 FAP_G5 ELOVL7 12.78 20.86 0.107 5 68687681 FAP_G5 RAD17 142.77 25.05 0.148 6 25529084 FAP_G5 LRRC16A 45.69 28.26 0.055 6 52268214 FAP_G5 PAQR8 105.87 88.16 0.284 6 109322505 FAP_G5 SESN1 34.5 32.18 0.061 7 99490177 FAP_G5 TRIM4 264.36 27.64 0.053 7 112424712 FAP_G5 TMEM168 17.79 52.53 0.065 7 127970910 FAP_G5 RBM28 53.45 24.6 0.059

8 90967511 FAP_G5 NBN 276.99 31.11 0.183 9 5811133 FAP_G5 ERMP1 155.28 34.68 0.136 X 122755071 FAP_G5 THOC2 180.38 25.47 0.095 1 31766071 FAP_G53 SNRNP40 183.75 27.8 0.094 1 91405165 FAP_G53 ZNF644 170.39 31.75 0.104 1 172579236 FAP_G53 SUCO 212.1 18.09 0.074 1 222802633 FAP_G53 MIA3 190.42 17.34 0.167 10 15255510 FAP_G53 FAM171A1 305.51 27.48 0.065 10 24909895 FAP_G53 ARHGAP21 56.63 23.26 0.093 10 38343543 FAP_G53 ZNF33A 135.69 25.01 0.064 10 47000081 FAP_G53 GPRIN2 146.91 24.29 0.16 10 88227154 FAP_G53 WAPAL 211.64 18.29 0.056 10 126454016 FAP_G53 METTL10 126.87 11.67 0.092 11 3794866 FAP_G53 NUP98 485.93 16.67 0.167 11 77413469 FAP_G53 RSF1 483.67 10.75 0.115 12 29496096 FAP_G53 ERGIC2 116.98 51.18 0.056 12 30833472 FAP_G53 IPO8 111.14 22.16 0.103 12 57648788 FAP_G53 R3HDM2 98.83 15.17 0.1 14 45675309 FAP_G53 MIS18BP1 264.12 12.88 0.083 15 25584316 FAP_G53 UBE3A 72.79 31.53 0.076 15 45408409 FAP_G53 DUOXA2 14.89 65.2 0.435 15 59455377 FAP_G53 MYO1E 70.4 27.58 0.053 15 65472500 FAP_G53 CLPX 197.02 33.55 0.056 16 11873075 FAP_G53 ZC3H7A 115.75 18.73 0.094 16 74530385 FAP_G53 GLG1 403.95 21.91 0.105 17 5392612 FAP_G53 MIS12 200.43 16.04 0.058 17 5392614 FAP_G53 MIS12 38.16 16.04 0.056 17 60038270 FAP_G53 MED13 298.56 14.08 0.095 19 50985463 FAP_G53 EMC10 207.2 126.54 0.053 19 55610399 FAP_G53 PPP1R12C 304.1 37.36 0.116 2 88876108 FAP_G53 EIF2AK3 140 17.3 0.07

20 34241753 FAP_G53 RBM12 39.49 15.58 0.111 20 43615935 FAP_G53 STK4 305.43 11.71 0.107 22 50898397 FAP_G53 SBF1 22.89 25.18 0.13 3 49053638 FAP_G53 DALRD3 460.19 20.99 0.061 3 58256683 FAP_G53 ABHD6 228.83 22.25 0.154 3 125725917 FAP_G53 SLC41A3 57.07 26.16 0.057 3 127394887 FAP_G53 ABTB1 72.41 26.93 0.067 4 84393409 FAP_G53 FAM175A 127.97 10.76 0.071 4 146044645 FAP_G53 ABCE1 47.06 27.31 0.111 5 143537991 FAP_G53 YIPF5 153.13 39.58 0.063 5 157162895 FAP_G53 THG1L 44.9 25.64 0.135 6 17765056 FAP_G53 KIF13A 217.82 37.1 0.075 6 42937639 FAP_G53 PEX6 77.14 11.98 0.115 6 74354277 FAP_G53 SLC17A5 109.19 50.68 0.074 6 80878721 FAP_G53 BCKDHB 168.56 37.24 0.068 7 1588176 FAP_G53 TMEM184A 22.95 15.21 0.071 8 124266478 FAP_G53 ZHX1 133.1 20.2 0.069 9 123538378 FAP_G53 FBXW2 199.72 14.43 0.073 1 27621110 FAP_G55 WDTC1 101.39 25.4 0.085 1 144923722 FAP_G55 PDE4DIP 378.62 19.86 0.052 1 231044470 FAP_G55 TTC13 57.62 20.44 0.096 10 32120676 FAP_G55 ARHGAP12 55.21 33.42 0.083 11 68029126 FAP_G55 C11orf24 236.21 31.36 0.055 12 432248 FAP_G55 KDM5A 137.65 10.25 0.227 12 27183115 FAP_G55 MED21 242.45 26.36 0.1 12 29496096 FAP_G55 ERGIC2 116.98 46.28 0.065 12 64816983 FAP_G55 XPOT 171.27 22.7 0.146 12 67663535 FAP_G55 CAND1 214.41 39.35 0.108 12 108941677 FAP_G55 SART3 353.67 14.26 0.143 14 36192335 FAP_G55 RALGAPA1 42.5 15.54 0.107 17 40476850 FAP_G55 STAT3 20.96 50.34 0.081

2 54122754 FAP_G55 PSME4 281 15.49 0.115 20 45853164 FAP_G55 ZMYND8 262.65 18.87 0.078 22 41833246 FAP_G55 TOB2 128.56 26.09 0.085 3 194152560 FAP_G55 ATP13A3 267.99 38.31 0.076 5 131039787 FAP_G55 FNIP1 114.73 10.33 0.176 5 133295258 FAP_G55 C5orf15 206.77 60.93 0.06 6 74354277 FAP_G55 SLC17A5 109.19 58.57 0.086 6 168272981 FAP_G55 MLLT4 130.32 72.52 0.053 7 92730738 FAP_G55 SAMD9 172.22 29.33 0.122 7 99490177 FAP_G55 TRIM4 264.36 21.62 0.058 7 108112925 FAP_G55 PNPLA8 459.09 21.98 0.12 9 95004492 FAP_G55 IARS 27.17 23.23 0.055 X 118979205 FAP_G55 UPF3B 211.22 13.32 0.167 1 11155838 FAP_G6 EXOSC10 244.88 44.48 0.06 1 52280223 FAP_G6 NRD1 295.52 61.38 0.082 1 70705133 FAP_G6 SRSF11 136.81 110.15 0.055 1 86842004 FAP_G6 ODF2L 68.73 30.54 0.12 1 145368619 FAP_G6 NBPF10 105.45 12.93 0.113 10 70725198 FAP_G6 DDX21 129.46 41.34 0.181 10 75290100 FAP_G6 USP54 435.41 31.75 0.081 10 99969326 FAP_G6 R3HCC1L 191.32 19.37 0.158 11 10875015 FAP_G6 ZBED5 336.44 39.45 0.053 11 43465666 FAP_G6 TTC17 263.56 34.92 0.096 11 64594831 FAP_G6 CDC42BPG 34.17 22.24 0.053 11 70218481 FAP_G6 PPFIA1 89.3 27.18 0.068 12 51389433 FAP_G6 SLC11A2 107.64 43.79 0.089 12 62798030 FAP_G6 USP15 289.35 19.05 0.156 12 64816983 FAP_G6 XPOT 225.75 31 0.095 12 90020290 FAP_G6 ATP2B1 149.34 33.19 0.066 12 110451041 FAP_G6 ANKRD13A 174.57 45.15 0.072 13 97986624 FAP_G6 MBNL2 138.85 29.65 0.098

15 49304896 FAP_G6 SECISBP2L 150.25 18.29 0.133 16 11873075 FAP_G6 ZC3H7A 115.75 26.45 0.063 16 15178538 FAP_G6 RRN3 37.67 33.05 0.064 16 22343403 FAP_G6 POLR3E 134.96 20.02 0.088 16 72138457 FAP_G6 DHX38 267.95 27.24 0.111 17 27438740 FAP_G6 MYO18A 70.5 37.19 0.2 18 18539865 FAP_G6 ROCK1 23.84 21.94 0.109 19 7702069 FAP_G6 STXBP2 44.73 99.84 0.1 19 19906229 FAP_G6 ZNF506 92.66 16 0.091 19 40392499 FAP_G6 FCGBP 31.36 322.08 0.065 2 11356307 FAP_G6 ROCK2 433.54 52.78 0.068 2 37486763 FAP_G6 PRKD3 107.4 15.43 0.077 2 39213243 FAP_G6 SOS1 251.79 16.72 0.098 2 86357778 FAP_G6 PTCD3 323.66 27.07 0.061 2 88888285 FAP_G6 EIF2AK3 268.94 30.09 0.061 2 158152993 FAP_G6 GALNT5 327.08 78.27 0.095 20 6060206 FAP_G6 FERMT1 46.37 62.98 0.056 3 9876962 FAP_G6 TTLL3 77.41 12.36 0.093 3 25647591 FAP_G6 TOP2B 136.86 59.03 0.127 3 38263085 FAP_G6 OXSR1 391.59 29.16 0.123 3 136287629 FAP_G6 STAG1 50.71 24.43 0.111 4 69816847 FAP_G6 UGT2A3 65.62 66.84 0.055 4 190873406 FAP_G6 FRG1 190.98 50.64 0.057 5 68408981 FAP_G6 SLC30A5 340.12 40.77 0.099 5 127474360 FAP_G6 SLC12A2 153.86 102.38 0.057 6 13632610 FAP_G6 RANBP9 79.97 26.14 0.091 6 114181549 FAP_G6 MARCKS 203.29 129.49 0.061 7 91724401 FAP_G6 AKAP9 392.07 53.21 0.056 7 117292925 FAP_G6 CFTR 14.08 93.9 0.062 9 5811133 FAP_G6 ERMP1 155.28 35.79 0.088 9 6887960 FAP_G6 KDM4C 401.16 21.83 0.231

9 32544122 FAP_G6 TOPORS 333.59 15.13 0.333 9 72933855 FAP_G6 SMC5 225.75 30.06 0.113 9 140099512 FAP_G6 TMEM203 24.25 30.24 0.054 X 2408462 FAP_G6 ZBED1 60.64 28.78 0.053 X 122755071 FAP_G6 THOC2 180.38 26.38 0.086 1 19644274 FAP_G61 PQLC2 184.02 10.01 0.333 1 40312897 FAP_G61 TRIT1 430.81 24.64 0.113 1 58999868 FAP_G61 OMA1 35.42 29.73 0.069 10 27409370 FAP_G61 YME1L1 61.53 84.12 0.113 10 112055084 FAP_G61 SMNDC1 436.24 32.06 0.118 10 114912131 FAP_G61 TCF7L2 192.54 42.84 0.096 11 70218481 FAP_G61 PPFIA1 85.6 26.85 0.074 11 96104236 FAP_G61 CCDC82 95.92 15.38 0.068 12 59271483 FAP_G61 LRIG3 419.96 30.65 0.085 12 116421103 FAP_G61 MED13L 198.46 18.33 0.125 13 39616313 FAP_G61 NHLRC3 294.29 28.46 0.065 13 40233534 FAP_G61 COG6 56.62 19.11 0.133 13 48985899 FAP_G61 LPAR6 156.89 22.77 0.094 14 58832276 FAP_G61 ARID4A 366.25 11.61 0.088 14 95566244 FAP_G61 DICER1 482.9 26.07 0.068 14 102452081 FAP_G61 DYNC1H1 97.81 45.02 0.077 15 59964846 FAP_G61 BNIP2 106.69 31.38 0.059 17 7219486 FAP_G61 NEURL4 49.54 10.7 0.114 17 37682263 FAP_G61 CDK12 56.34 15.9 0.064 17 47679242 FAP_G61 SPOP 218.46 34.42 0.057 17 57153072 FAP_G61 TRIM37 58.11 13.29 0.118 17 63532654 FAP_G61 AXIN2 356.33 107.77 0.086 19 2076868 FAP_G61 MOB3A 83.2 12.67 0.097 19 4363452 FAP_G61 SH3GL1 52.09 38.04 0.096 19 4694711 FAP_G61 DPP9 65.82 25.26 0.051 19 40411811 FAP_G61 FCGBP 91.04 384.26 0.069

2 10729751 FAP_G61 NOL10 125.11 22.94 0.088 2 109365413 FAP_G61 RANBP2 247.25 41.19 0.15 2 160257175 FAP_G61 BAZ2B 124.93 16.61 0.2 20 30785453 FAP_G61 PLAGL2 134.4 20.04 0.111 20 33329244 FAP_G61 NCOA6 83.84 16.53 0.058 20 61833730 FAP_G61 YTHDF1 15.77 29.45 0.273 21 33065618 FAP_G61 SCAF4 297.18 16.92 0.088 21 33067133 FAP_G61 SCAF4 395.84 16.92 0.064 3 44437977 FAP_G61 TCAIM 135.36 22.71 0.313 3 49719861 FAP_G61 APEH 98.59 92.46 0.115 3 52263205 FAP_G61 TWF2 101.7 32.51 0.183 3 113672641 FAP_G61 ZDHHC23 301.57 21.74 0.111 3 133339107 FAP_G61 TOPBP1 150.92 20.59 0.053 3 138290147 FAP_G61 CEP70 42.02 19.98 0.068 3 142281435 FAP_G61 ATR 123.87 12.26 0.217 3 145789075 FAP_G61 PLOD2 136.27 42.71 0.08 4 48636444 FAP_G61 FRYL 123.36 50.84 0.119 5 122154534 FAP_G61 SNX2 44.76 67.52 0.081 5 137726897 FAP_G61 KDM3B 60.09 29.83 0.137 6 33264397 FAP_G61 RGL2 36.88 17.06 0.063 6 101127558 FAP_G61 ASCC3 65.46 25.3 0.171 6 109772841 FAP_G61 MICAL1 62.22 37.69 0.085 7 73666763 FAP_G61 RFC2 260.69 20.5 0.138 7 99516985 FAP_G61 TRIM4 470.03 16.45 0.115 7 135261066 FAP_G61 NUP205 157.98 23.64 0.156 7 150778661 FAP_G61 TMUB1 16.32 47.94 0.056 9 77377526 FAP_G61 TRPM6 16.47 13.39 0.097 X 53617968 FAP_G61 HUWE1 178.23 24.24 0.111 1 41536272 FAP_G67 SCMH1 21.17 16.06 0.095 1 146658499 FAP_G67 FMO5 70.46 16.67 0.073 10 95276744 FAP_G67 CEP55 32.23 25.57 0.071

10 99215538 FAP_G67 ZDHHC16 37.44 30.12 0.059 12 12483767 FAP_G67 MANSC1 383.6 24.28 0.051 12 49316809 FAP_G67 FKBP11 15.46 68.65 0.176 12 115115392 FAP_G67 TBX3 18.14 14.76 0.106 14 51375597 FAP_G67 PYGL 421.96 13.76 0.141 14 53250203 FAP_G67 GNPNAT1 20.73 38.84 0.167 17 73871103 FAP_G67 TRIM47 78.71 19.2 0.059 19 2434036 FAP_G67 LMNB2 17.17 31.16 0.061 2 148712924 FAP_G67 ORC4 23.91 17.68 0.096 2 198263198 FAP_G67 SF3B1 95.79 99.71 0.438 22 20939438 FAP_G67 MED15 74.1 19.13 0.069 3 45785155 FAP_G67 SACM1L 22.36 18.87 0.054 3 51993981 FAP_G67 PCBP4 32.77 18.22 0.063 3 69124582 FAP_G67 UBA3 17.72 55.82 0.051 5 77409625 FAP_G67 AP3B1 351.77 19.84 0.06 6 110533440 FAP_G67 CDC40 47.07 15.29 0.143 7 129064718 FAP_G67 AHCYL2 72.47 19.08 0.119 9 84249101 FAP_G67 TLE1 26.84 16.53 0.063 X 118716593 FAP_G67 UBE2A 123.48 49.98 0.784 1 16271286 _EBL1 ZBTB17 120.34 12.83 0.282 10 27009239 _EBL1 PDSS1 34.73 25.5 0.093 10 70056661 _EBL1 PBLD 237.87 55.53 0.051 11 67413234 _EBL1 ACY3 220.61 16.32 0.097 15 34659235 _EBL1 LPCAT4 69.14 72.96 0.081 15 35163023 _EBL1 AQR 67.19 11.17 0.114 15 65885839 _EBL1 VWA9 76.83 41.69 0.053 17 648188 _EBL1 GEMIN4 200.08 13.24 0.073 17 41168352 _EBL1 VAT1 92.4 16.61 0.082 17 45662948 _EBL1 NPEPPS 138.42 33.65 0.182 17 45662950 _EBL1 NPEPPS 133.55 33.65 0.182 17 46675419 _EBL1 HOXB6 164.81 36.7 0.061

19 19766136 _EBL1 ATP13A1 106.83 18.82 0.067 19 53270614 _EBL1 ZNF600 412.07 21.1 0.1 2 73989808 _EBL1 DUSP11 213.27 28.22 0.07 3 120360492 _EBL1 HGD 197.16 19.44 0.07 3 122271386 _EBL1 PARP9 494.64 15.53 0.2 4 83785674 _EBL1 SEC31A 473.34 48.43 0.089 5 175925969 _EBL1 FAF2 27.34 18.13 0.222 6 109308758 _EBL1 SESN1 41.23 41.7 0.052 7 1510770 _EBL1 INTS1 104.33 11.8 0.054 9 91965713 _EBL1 SECISBP2 97.5 27.01 0.1 X 2867517 _EBL1 ARSE 154.37 30.81 0.057 X 107331187 _EBL1 PSMD10 326.39 56.16 0.052 1 6314643 _EBL11 GPR153 137.14 16.37 0.1 1 16057710 _EBL11 PLEKHM2 76.42 26.06 0.2 1 16458713 _EBL11 EPHA2 36.17 33.31 0.273 1 22155398 _EBL11 HSPG2 193.57 19.45 0.067 1 28120091 _EBL11 STX12 115.02 38.36 0.079 1 29319988 _EBL11 EPB41 13.62 28.65 0.119 1 32052488 _EBL11 TINAGL1 225.86 121.58 0.289 1 33251967 _EBL11 YARS 148.5 33.54 0.096 1 35457949 _EBL11 ZMYM6 422.19 11.87 0.067 1 40035652 _EBL11 PABPC4 172.16 63.6 0.089 1 45268740 _EBL11 PLK3 30.36 10.03 0.278 1 45269329 _EBL11 PLK3 48.76 10.03 0.088 1 54394090 _EBL11 HSPB11 197.34 45.33 0.065 1 60370607 _EBL11 CYP2J2 231.36 46.5 0.062 1 90401061 _EBL11 LRRC8D 226.07 17.92 0.06 1 114948225 _EBL11 TRIM33 207.28 11.75 0.094 1 151400320 _EBL11 POGZ 125.49 28.91 0.14 1 153904888 _EBL11 DENND4B 42.07 15.89 0.098 1 155171818 _EBL11 THBS3 60.19 17.59 0.087

1 155233110 _EBL11 CLK2 113.54 39.25 0.077 1 161092043 _EBL11 DEDD 66.2 28.69 0.052 1 161145766 _EBL11 B4GALT3 53.23 29.41 0.208 1 207263776 _EBL11 C4BPB 321.69 18.59 0.269 1 225611624 _EBL11 LBR 340.49 53.7 0.057 10 24909487 _EBL11 ARHGAP21 348.75 31.13 0.268 10 25241473 _EBL11 PRTFDC1 105.98 14.51 0.098 10 43089907 _EBL11 ZNF33B 60.73 19.82 0.089 10 99225818 _EBL11 MMS19 156.19 36.1 0.057 10 100144755 _EBL11 PYROXD2 80.45 13.64 0.091 10 124361540 _EBL11 DMBT1 53.34 119.07 0.28 11 290067 _EBL11 ATHL1 81.58 106.18 0.063 11 408728 _EBL11 SIGIRR 363.9 98.83 0.25 11 824427 _EBL11 PNPLA2 76.85 79.87 0.057 11 6503444 _EBL11 TIMM10B 72.42 28.77 0.319 11 46702069 _EBL11 ARHGAP1 36.71 48.35 0.089 11 47788722 _EBL11 FNBP4 24.23 31.17 0.2 11 47857271 _EBL11 NUP160 79.97 19.97 0.156 11 60899372 _EBL11 VPS37C 280.87 18.2 0.241 11 62415354 _EBL11 INTS5 13.84 15.81 0.349 11 64789244 _EBL11 ARL2 51.21 115.43 0.074 11 66102383 _EBL11 RIN1 78.98 14.52 0.107 11 66333833 _EBL11 CTSF 36.53 32.31 0.276 11 67206339 _EBL11 CORO1B 90.3 157.49 0.205 11 68377486 _EBL11 PPP6R3 68.27 38.98 0.059 11 71726538 _EBL11 NUMA1 94.94 114.81 0.113 11 74081973 _EBL11 PGM2L1 25.2 11.4 0.25 11 76062172 _EBL11 PRKRIR 493.35 53.48 0.057 11 86519164 _EBL11 PRSS23 41.12 43.57 0.072 11 118923405 _EBL11 HYOU1 86.28 51.89 0.204 11 125450086 _EBL11 EI24 31.75 106.38 0.281 12 6730093 _EBL11 LPAR5 61.63 19.43 0.1

12 7310205 _EBL11 CTN3 87.24 15.04 0.083 12 46321475 _EBL11 SCAF11 205.25 25.23 0.083 12 57422573 _EBL11 MYO1A 434.22 57.51 0.082 12 64815055 _EBL11 XPOT 37.21 29.98 0.056 12 104376924 _EBL11 TDG 90.15 23.94 0.127 12 115115392 _EBL11 TBX3 224.27 40.7 0.094 12 118490118 _EBL11 WSB2 166.1 50.94 0.073 12 118597978 _EBL11 TAOK3 29.87 27.98 0.051 12 122848582 _EBL11 CLIP1 185.73 16.42 0.091 12 124810805 _EBL11 NCOR2 284.63 27.11 0.322 13 77581590 _EBL11 FBXL3 129.61 32 0.252 13 113750733 _EBL11 MCF2L 139.42 18.97 0.257 14 21868763 _EBL11 CHD8 43 14.47 0.258 14 23608730 _EBL11 SLC7A8 63.63 29.19 0.246 14 88946246 _EBL11 PTPN21 45.23 13.15 0.121 14 102974193 _EBL11 ANKRD9 41.68 20.54 0.393 14 103410815 _EBL11 CDC42BPB 41.97 44.1 0.086 14 105834860 _EBL11 PACS2 55.13 19.83 0.235 15 67073523 _EBL11 SMAD6 176.89 13.42 0.397 15 75137840 _EBL11 SCAMP2 72.27 165.4 0.236 15 85327072 _EBL11 ZNF592 112.25 12.64 0.367 16 1774657 _EBL11 MAPK8IP3 422.3 31.6 0.132 16 15728763 _EBL11 KIAA0430 106.05 27.62 0.07 16 30594011 _EBL11 ZNF785 110.97 10.06 0.162 16 30764825 _EBL11 PHKG2 33.02 15.74 0.107 16 55565859 _EBL11 LPCAT2 225.88 14.71 0.13 16 57059431 _EBL11 NLRC5 17.04 16.72 0.143 16 67318291 _EBL11 PLEKHG4 36.41 43.67 0.076 16 70505232 _EBL11 FUK 68.15 19.63 0.196 16 74537509 _EBL11 GLG1 118.98 38.61 0.238 16 74725195 _EBL11 MLKL 69.27 25.34 0.11

16 88790327 _EBL11 PIEZO1 80.82 30.57 0.111 16 90020704 _EBL11 DEF8 140.64 36.06 0.108 17 649105 _EBL11 GEMIN4 70.41 15.82 0.167 17 18150001 _EBL11 FLII 187.37 69.27 0.079 17 27903134 _EBL11 GIT1 60.16 32.92 0.071 17 30774035 _EBL11 PSMD11 35.63 33.99 0.127 17 36061132 _EBL11 HNF1B 10.85 31.11 0.13 17 40266550 _EBL11 KAT2A 163.32 46.15 0.09 17 40457655 _EBL11 STAT5A 89.68 20.12 0.333 17 40765726 _EBL11 TUBG1 104.51 18.73 0.063 17 43198386 _EBL11 PLCD3 37.86 70.21 0.17 17 47684665 _EBL11 SPOP 95.46 35.7 0.057 17 79653397 _EBL11 HGS 47.23 62.84 0.356 17 80405477 _EBL11 C17orf62 27.86 64.63 0.206 17 80529628 _EBL11 FOXK2 42.58 16.01 0.282 18 9570178 _EBL11 PPP4R1 232.29 28.69 0.075 18 10546355 _EBL11 NAPG 95.71 20.47 0.149 19 2810473 _EBL11 THOP1 156.79 18.47 0.115 19 5832434 _EBL11 FUT6 87.37 40.23 0.13 19 7677237 _EBL11 CAMSAP3 87.38 20.15 0.253 19 10202224 _EBL11 C19orf66 14.38 30.58 0.091 19 10244896 _EBL11 DNMT1 79.37 16.14 0.121 19 10602587 _EBL11 KEAP1 166.41 53.63 0.37 19 11135016 _EBL11 SMARCA4 64.28 34.61 0.233 19 14023169 _EBL11 CC2D1A 187.57 37.35 0.141 19 15512067 _EBL11 AKAP8L 46.84 30.44 0.314 19 16652753 _EBL11 CHERP 221.82 21.73 0.094 19 17322818 _EBL11 MYO9B 42.72 20.38 0.114 19 18280045 _EBL11 PIK3R2 46.69 38.56 0.167 19 37004945 _EBL11 ZNF260 322.35 10.88 0.115 19 39412285 _EBL11 SARS2 106.97 20.69 0.178

19 46274305 _EBL11 DMPK 13.66 20.66 0.379 19 47197212 _EBL11 PRKD2 41.54 26.95 0.06 19 47773684 _EBL11 CCDC9 292.29 18.71 0.075 19 53270953 _EBL11 ZNF600 57.76 24.79 0.095 19 56113688 _EBL11 ZNF524 35.45 39.64 0.202 19 56151940 _EBL11 ZNF580 313.14 14.02 0.143 2 9650119 _EBL11 ADAM17 70.52 12.65 0.119 2 25966873 _EBL11 ASXL2 35.52 10.17 0.346 2 27600985 _EBL11 ZNF513 18.98 27.65 0.33 2 32842934 _EBL11 BIRC6 442.19 13.47 0.081 2 74720325 _EBL11 TTC31 90.38 20.77 0.213 2 86992166 _EBL11 RMND5A 49.33 34.79 0.059 2 88472847 _EBL11 THNSL2 160.89 25.68 0.19 2 96970563 _EBL11 SNRNP200 49.25 67.9 0.329 2 103324746 _EBL11 SLC9A2 156.6 38.4 0.261 2 128346068 _EBL11 MYO7B 157.74 50.64 0.07 2 158115261 _EBL11 GALNT5 239.69 20.38 0.117 2 158617517 _EBL11 ACVR1 172 13.19 0.176 2 159535161 _EBL11 PKP4 167.65 29.95 0.083 2 176803073 _EBL11 KIAA1715 277.37 10.19 0.118 2 191797488 _EBL11 G 131.21 35.71 0.065 2 236649677 _EBL11 AGAP1 17.4 10.71 0.258 20 48808408 _EBL11 CEBPB 110.25 20.22 0.069 20 62904741 _EBL11 PCMTD2 170.58 46.09 0.054 21 37571525 _EBL11 DOPEY2 429.02 15.57 0.174 21 45389078 _EBL11 AGPAT3 187.22 33.42 0.076 22 21098990 _EBL11 PI4KA 74.65 31.17 0.137 22 22142997 _EBL11 MAPK1 44.94 47.06 0.053 22 23524342 _EBL11 BCR 44.9 20.15 0.175 22 24176338 _EBL11 SMARCB1 142.28 72.96 0.051 22 30741038 _EBL11 SF3A1 130.31 34.02 0.152

22 32112237 _EBL11 PRR14L 236.96 10.65 0.2 22 37154359 _EBL11 IFT27 356.22 31.82 0.095 22 37421079 _EBL11 MPST 20.42 140.14 0.231 22 38690510 _EBL11 CSNK1E 40.2 64.93 0.382 22 50280342 _EBL11 ZBED4 89.07 12.11 0.225 22 50665222 _EBL11 TUBGCP6 179.99 20.18 0.071 22 50727457 _EBL11 PLXNB2 19.41 95.53 0.268 3 5024901 _EBL11 BHLHE40 263.97 69.15 0.065 3 9807533 _EBL11 CAMK1 35.96 16.37 0.143 3 11831999 _EBL11 TAMM41 102.74 12.82 0.16 3 36872961 _EBL11 TRANK1 112.12 11.61 0.135 3 42602720 _EBL11 SEC22C 82.7 15.66 0.118 3 47454515 _EBL11 PTPN23 70.88 17.79 0.129 3 53215570 _EBL11 PRKCD 115.95 55.5 0.066 3 98251487 _EBL11 GPR15 57.82 17.47 0.162 3 127335729 _EBL11 MCM2 131.23 14.5 0.348 3 127398960 _EBL11 ABTB1 85.08 52.2 0.289 3 186504995 _EBL11 EIF4A2 28.15 420.31 0.07 4 1991480 _EBL11 NELFA 104.71 31.3 0.115 4 6588879 _EBL11 MAN2B2 59.27 29.84 0.118 4 56233791 _EBL11 SRD5A3 60.21 21.99 0.257 4 71888128 _EBL11 DCK 102.62 24.13 0.069 4 84194682 _EBL11 COQ2 45.37 24.52 0.307 4 115597107 _EBL11 UGT8 475.7 46.33 0.406 4 148554112 _EBL11 TMEM184C 37.28 26.45 0.076 4 159158777 _EBL11 TMEM144 100.22 22.7 0.151 4 170618575 _EBL11 CLCN3 34.37 57.19 0.161 4 170625194 _EBL11 CLCN3 20.76 57.19 0.057 5 138643409 _EBL11 MATR3 77.45 107.61 0.068 5 141248235 _EBL11 PCDH1 71.83 43.57 0.085 5 154181850 _EBL11 LARP1 62.77 47.98 0.17

5 176863182 _EBL11 GRK6 74.98 35.13 0.053 5 179193128 _EBL11 MAML1 22.7 19.43 0.083 6 4128047 _EBL11 ECI2 60.88 100.98 0.201 6 7246716 _EBL11 RREB1 20.66 14.62 0.15 6 27114400 _EBL11 HIST1H2BK 42.74 76.51 0.051 6 30888131 _EBL11 VARS2 136.47 19.22 0.375 6 31378531 _EBL11 MICA 192.49 25.01 0.056 6 31608178 _EBL11 BAG6 41.77 82.77 0.059 6 33163446 _EBL11 RXRB 70.83 35.44 0.169 6 42637958 _EBL11 UBR2 116.76 20.63 0.271 6 42713106 _EBL11 TBCC 69 29.63 0.071 6 112397206 _EBL11 TUBE1 35.6 12.52 0.172 6 116288819 _EBL11 FRK 73.39 10.86 0.129 6 126210494 _EBL11 NCOA7 495.98 87.75 0.538 6 131277326 _EBL11 EPB41L2 304.79 88.23 0.054 6 138752775 _EBL11 NHSL1 22.45 18.25 0.133 7 11022426 _EBL11 PHF14 285.71 23.28 0.167 7 26225198 _EBL11 NFE2L3 112.4 32.38 0.077 7 27856620 _EBL11 TAX1BP1 173.81 86.35 0.108 7 98592387 _EBL11 TRRAP 36.9 10.46 0.383 7 127725768 _EBL11 SND1 118.22 94.94 0.367 7 135612041 _EBL11 LUZP6 119.49 34.57 0.153 7 144072739 _EBL11 ARHGEF5 52.51 34.94 0.167 7 150815308 _EBL11 AGAP3 56.88 27.6 0.24 7 150840854 _EBL11 AGAP3 44.5 27.6 0.315 8 21978233 _EBL11 HR 102.96 25.66 0.087 8 22472943 _EBL11 KIAA1967 201.46 43.95 0.153 8 54897048 _EBL11 TCEA1 319.62 79.3 0.064 8 104413804 _EBL11 SLC25A32 75.26 13.22 0.391 8 125498537 _EBL11 RNF139 71.17 18.29 0.064 8 125568091 _EBL11 MTSS1 66.82 13.08 0.265

8 144391660 _EBL11 TOP1MT 10.66 45.48 0.071 8 144668451 _EBL11 EEF1D 16.15 405.35 0.116 8 144809362 _EBL11 FAM83H 15.12 32.7 0.088 8 145583012 _EBL11 SLC52A2 25.53 54.47 0.174 8 145622567 _EBL11 CPSF1 83.85 68.73 0.288 9 5772989 _EBL11 KIAA1432 65.67 10.19 0.2 9 26842592 _EBL11 CAAP1 104.58 34.88 0.142 9 34241785 _EBL11 UBAP1 22.95 28.49 0.092 9 35751663 _EBL11 RGP1 219.87 22.21 0.069 9 35846946 _EBL11 TMEM8B 62.13 14.51 0.25 9 36222777 _EBL11 GNE 25.95 39.63 0.054 9 37442136 _EBL11 ZBTB5 18.58 11.39 0.094 9 79118205 _EBL11 GCNT1 200.42 43.16 0.093 9 100407441 _EBL11 NCBP1 29.24 20.27 0.053 9 112153825 _EBL11 PTPN3 136.46 25.18 0.123 9 132396373 _EBL11 NTMT1 32.52 39.47 0.089 9 132401692 _EBL11 ASB6 132.76 13.29 0.143 9 135772951 _EBL11 TSC1 381.51 17.83 0.186 9 135796795 _EBL11 TSC1 143.77 17.83 0.265 9 140327677 _EBL11 NOXA1 80.61 45.09 0.159 X 40571440 _EBL11 MED14 150.93 24.19 0.107 X 41428923 _EBL11 CASK 94.05 26.09 0.086 X 53565299 _EBL11 HUWE1 120.25 19.69 0.053 X 71715059 _EBL11 HDAC8 58.48 14.61 0.25 X 129270668 _EBL11 AIFM1 39.75 46.32 0.063 1 35656965 _EBL13 SFPQ 17.1 38.71 0.066 1 192993039 _EBL13 UCHL5 79.44 13.21 0.054 10 32594774 _EBL13 EPC1 100.22 12.84 0.143 10 74310955 _EBL13 MICU1 215.05 31.86 0.065 11 47767738 _EBL13 FNBP4 160.28 10.96 0.188 11 66307005 _EBL13 ZDHHC24 205.66 14.87 0.087

12 7362390 _EBL13 PEX5 184 17.97 0.063 12 56713198 _EBL13 PAN2 38.1 11.36 0.077 14 92249463 _EBL13 TC2N 50.93 15.73 0.063 14 103396555 _EBL13 AMN 5.18 206.39 0.113 15 23931544 _EBL13 NDN 37.88 14.55 0.097 16 2580432 _EBL13 AMDHD2 11.69 13.78 0.116 17 63532654 _EBL13 AXIN2 7.88 10.92 0.194 19 4048037 _EBL13 ZBTB7A 155.17 13.92 0.12 19 4174816 _EBL13 SIRT6 461.31 45.31 0.103 19 5844049 _EBL13 FUT3 29.94 176.74 0.093 19 10479061 _EBL13 TYK2 26.96 21.46 0.07 19 17424837 _EBL13 DDA1 223.08 15.91 0.055 19 33137455 _EBL13 ANKRD27 40.15 16.18 0.158 19 50512555 _EBL13 VRK3 254.01 31.47 0.056 19 55748077 _EBL13 PPP6R1 69.21 19.45 0.062 19 56600074 _EBL13 ZNF787 29.03 21.96 0.059 2 27248479 _EBL13 MAPRE3 326.34 17.58 0.125 2 43452252 _EBL13 ZFP36L2 54.42 74.45 0.059 22 29754717 _EBL13 AP1B1 6.94 43.8 0.057 22 36537393 _EBL13 APOL3 41.87 13.06 0.061 22 50894811 _EBL13 SBF1 47.45 14.86 0.128 22 51009381 _EBL13 CPT1B 24.8 12.21 0.063 3 33454225 _EBL13 UBP1 287.54 24.37 0.056 3 49463821 _EBL13 NICN1 100.43 10.01 0.154 3 127294066 _EBL13 TPRA1 9.78 27.26 0.051 4 89053735 _EBL13 ABCG2 39.44 15.21 0.065 5 80600766 _EBL13 ZCCHC9 425.86 16.57 0.053 5 132161651 _EBL13 SHROOM1 41.7 16.69 0.15 6 129963123 _EBL13 ARHGAP18 263.25 15.45 0.065 7 150439604 _EBL13 GIMAP5 84.74 10.48 0.066 9 74365148 _EBL13 TMEM2 255.73 20.4 0.063

9 100675749 _EBL13 C9orf156 85.67 12.64 0.214 X 153760416 _EBL13 G6PD 204.29 17.94 0.074 11 6412879 _EBL18 SMPD1 123.04 14.9 0.286 11 22848809 _EBL18 SVIP 425.58 19.31 0.055 11 68566774 _EBL18 CPT1A 82.48 23.55 0.12 14 24658649 _EBL18 TM9SF1 18.02 18.95 0.081 14 54416869 _EBL18 BMP4 98.01 11.66 0.056 16 67477072 _EBL18 ATP6V0D1 19.77 100.79 0.16 2 28004495 _EBL18 RBKS 268.41 16.81 0.077 2 32117104 _EBL18 MEMO1 124.93 12.28 0.081 3 120369640 _EBL18 HGD 87.29 14.78 0.057 9 110249993 _EBL18 KLF4 43.46 60.56 0.086 1 116206406 _EBL20 VANGL1 163.88 12.71 0.229 1 150443672 _EBL20 RPRD2 142.87 15.97 0.137 1 151261988 _EBL20 ZNF687 339.82 15.02 0.115 1 156170092 _EBL20 SLC25A44 497.79 19.22 0.407 1 197070180 _EBL20 ASPM 28.48 11.87 0.176 1 214813895 _EBL20 CENPF 60.12 24.94 0.263 10 69669079 _EBL20 SIRT1 104.16 16.75 0.269 10 99126217 _EBL20 RRP12 162.91 11.56 0.467 10 102116489 _EBL20 SCD 481.22 16.22 0.326 11 1502029 _EBL20 MOB2 195.87 42.17 0.068 11 47595290 _EBL20 KBTBD4 40.03 12.11 0.239 11 65367161 _EBL20 MAP3K11 115.18 41.19 0.414 11 67413258 _EBL20 ACY3 199.91 16.91 0.115 11 72408974 _EBL20 ARAP1 156.5 41.6 0.068 11 113610024 _EBL20 ZW10 61.85 20.24 0.066 11 128354759 _EBL20 ETS1 182.27 32.14 0.059 12 6672264 _EBL20 NOP2 200 27.72 0.188 12 7287957 _EBL20 CTN3 37.69 14.25 0.097 12 49170986 _EBL20 ADCY6 274.66 39.84 0.088

12 51389433 _EBL20 SLC11A2 91.15 31.42 0.082 12 57581052 _EBL20 LRP1 289.69 20.18 0.333 12 96131660 _EBL20 NTN4 60.42 29.41 0.052 12 113398998 _EBL20 OAS3 21.95 19.97 0.233 13 25832766 _EBL20 MTMR6 14.85 18.18 0.106 13 113140351 _EBL20 TUBGCP3 240.28 13.8 0.209 13 113173318 _EBL20 TUBGCP3 239.95 13.8 0.237 14 32561374 _EBL20 ARHGAP5 208.13 27.82 0.154 14 73425409 _EBL20 DCAF4 229.16 18.17 0.176 14 74192807 _EBL20 ELMSAN1 80.52 10.56 0.4 14 88904182 _EBL20 SPATA7 46.59 13.6 0.2 15 35149234 _EBL20 AQR 466.69 25.02 0.073 15 78294061 _EBL20 TBC1D2B 15.18 31.67 0.076 16 2034824 _EBL20 GFER 27.42 23.79 0.053 16 2256513 _EBL20 MT8 139.42 46.99 0.32 16 15128407 _EBL20 PDXDC1 67.04 180.99 0.057 16 15178538 _EBL20 RRN3 37.67 33.48 0.078 16 20926901 _EBL20 LYRM1 37.94 31.62 0.121 16 29791468 _EBL20 ZG16 446.46 69.24 0.053 16 30581294 _EBL20 ZNF688 234.95 13.47 0.088 16 57685292 _EBL20 GPR56 420.7 90.15 0.065 16 87446394 _EBL20 ZCCHC14 121.86 13.17 0.407 17 16256369 _EBL20 CENPV 52.4 15.07 0.156 17 57644052 _EBL20 DHX40 331.05 40.49 0.056 17 60685402 _EBL20 TLK2 107.84 14.81 0.241 17 61908527 _EBL20 PSMC5 296.94 153.78 0.07 17 72951900 _EBL20 HID1 114.74 61.3 0.091 17 73565135 _EBL20 LLGL2 40.83 112.45 0.059 17 78323684 _EBL20 RNF213 148.31 21.44 0.089 17 80040467 _EBL20 FASN 292.45 17.98 0.065 19 4432036 _EBL20 CHAF1A 26.05 12.85 0.111

19 4816993 _EBL20 TICAM1 255.4 12.43 0.121 19 6222149 _EBL20 MLLT1 492.05 22.49 0.051 19 10434209 _EBL20 RAVER1 342.22 32.08 0.065 19 40318227 _EBL20 DYRK1B 269.11 14.42 0.105 19 45349844 _EBL20 PVRL2 98.05 75.21 0.355 19 48637292 _EBL20 LIG1 179.24 30.64 0.087 19 50909526 _EBL20 POLD1 362.67 15.15 0.367 19 53348448 _EBL20 ZNF468 100.03 14.91 0.2 2 15746146 _EBL20 DDX1 423.08 91.42 0.106 2 24920565 _EBL20 NCOA1 69.88 14.51 0.259 2 25042868 _EBL20 ADCY3 15.31 15.38 0.079 2 55906840 _EBL20 PNPT1 278.67 17.4 0.109 2 61552564 _EBL20 USP34 95.96 20.65 0.407 2 106498117 _EBL20 NCK2 64.85 39.84 0.069 2 128757642 _EBL20 SAP130 130.08 18.42 0.176 2 207018393 _EBL20 NDUFS1 33 58.97 0.086 2 223423144 _EBL20 SGPP2 90.51 32.56 0.096 2 228197140 _EBL20 MFF 353.62 54.4 0.07 20 3128351 _EBL20 FASTKD5 46.42 12.38 0.083 20 3765999 _EBL20 CENPB 69.98 40.12 0.18 20 31041135 _EBL20 C20orf112 48.54 27.74 0.113 20 37580382 _EBL20 FAM83D 30.45 34.26 0.067 20 50273482 _EBL20 ATP9A 47.3 66.82 0.208 20 62196829 _EBL20 HELZ2 45.88 10.11 0.308 20 62575924 _EBL20 UCKL1 146.42 28.35 0.161 22 21150444 _EBL20 PI4KA 233.41 35.15 0.2 22 41895859 _EBL20 ACO2 141.28 130.8 0.078 3 14199816 _EBL20 XPC 173.54 23.61 0.145 3 50356434 _EBL20 HYAL2 387.03 40.71 0.234 3 93598132 _EBL20 PROS1 97.12 23.97 0.125 3 101383533 _EBL20 ZBTB11 224.73 13.01 0.107

3 128350879 _EBL20 RPN1 178.64 255.94 0.061 3 196214359 _EBL20 RNF168 355.89 15.34 0.097 4 1987520 _EBL20 NELFA 153.81 23.28 0.416 4 48038104 _EBL20 NIPAL1 185.91 24.24 0.245 4 48559053 _EBL20 FRYL 125.28 59.31 0.116 4 89602464 _EBL20 HERC3 406.73 13.84 0.086 4 119686023 _EBL20 SEC24D 136.76 32.17 0.053 4 123236709 _EBL20 KIAA1109 119.1 15.07 0.111 4 159642531 _EBL20 PPID 183.07 51.71 0.083 4 184432014 _EBL20 ING2 113.57 17.85 0.333 4 184614801 _EBL20 TRAPPC11 47.13 23.12 0.078 5 77523337 _EBL20 AP3B1 5.78 54.18 0.141 5 95761546 _EBL20 PCSK1 184.57 26.33 0.167 5 112200429 _EBL20 SRP19 68.3 30.93 0.244 5 114552595 _EBL20 PGGT1B 59.88 21.54 0.167 5 115782326 _EBL20 SEMA6A 133.3 10.88 0.063 5 122881512 _EBL20 CSNK1G3 204.82 24.12 0.302 6 44102401 _EBL20 TMEM63B 37.42 35.92 0.265 6 138754503 _EBL20 NHSL1 372.94 20.06 0.12 7 6845644 _EBL20 CCZ1B 23.99 46.5 0.115 7 36489287 _EBL20 ANLN 395.72 28.08 0.114 7 111161406 _EBL20 IMMP2L 174.97 14.73 0.091 7 130135262 _EBL20 MEST 31.18 54.73 0.126 8 21860740 _EBL20 XPO7 37.27 33.9 0.257 8 22451332 _EBL20 PDLIM2 226.06 10.55 0.069 8 28633364 _EBL20 INTS9 92.75 17.55 0.143 8 38107309 _EBL20 DDHD2 47.44 16.41 0.2 8 38205365 _EBL20 WHSC1L1 256.04 27.19 0.065 8 90958486 _EBL20 NBN 62.67 31.73 0.071 8 145621703 _EBL20 CPSF1 42.29 36.35 0.175 8 145947222 _EBL20 ZNF251 203.92 10.19 0.133

9 33472026 _EBL20 NOL6 44.42 15.97 0.139 9 88918076 _EBL20 ZCCHC6 93.9 16.56 0.083 9 91961803 _EBL20 SECISBP2 465.36 31.85 0.125 9 101900288 _EBL20 TGFBR1 178.32 22.01 0.349 9 104314450 _EBL20 RNF20 285.21 28.65 0.074 9 140353513 _EBL20 NSMF 266.28 21.5 0.143 X 100268679 _EBL20 TRMT2B 206.21 18.45 0.182 X 100268681 _EBL20 TRMT2B 175.87 18.45 0.182 1 115226910 _EBL23 AMPD1 51.81 12.96 0.111 10 123239442 _EBL23 FGFR2 7.27 23.41 0.083 10 123721611 _EBL23 NSMCE4A 276.93 48.13 0.429 11 64757200 _EBL23 BATF2 9.05 14.84 0.136 11 124495763 _EBL23 TBRG1 15.12 11.52 0.087 14 102661425 _EBL23 WDR20 183.23 13.77 0.192 17 40490761 _EBL23 STAT3 243.14 36.08 0.052 17 58040212 _EBL23 RNFT1 15.25 23.35 0.056 19 51010849 _EBL23 JOSD2 13.39 24.89 0.121 2 190331199 _EBL23 WDR75 4.83 16.53 0.075 21 38524256 _EBL23 TTC3 234.53 29.27 0.196 3 49928891 _EBL23 MST1R 32.01 18.14 0.066 4 89060973 _EBL23 ABCG2 122.52 17.68 0.065 5 153755936 _EBL23 GALNT10 30.14 18 0.125 7 99506228 _EBL23 TRIM4 63.68 17.95 0.077 1 100207793 _EBL26 FRRS1 334.21 12.82 0.25 1 169993620 _EBL26 KIFAP3 18.24 34.02 0.058 1 208212977 _EBL26 PLXNA2 264.2 14.71 0.081 10 59976001 _EBL26 IPMK 245.52 10.72 0.22 10 64967560 _EBL26 JMJD1C 38.99 17.01 0.064 10 135106659 _EBL26 TUBGCP2 33.1 23.96 0.067 11 9812155 _EBL26 SBF2 75.99 15.4 0.073 12 9750654 _EBL26 KLRB1 468.63 72.48 0.063

12 48095339 _EBL26 RPAP3 391.2 16.03 0.068 12 115115385 _EBL26 TBX3 110.41 22.76 0.283 14 34419843 _EBL26 EGLN3 200.21 36.89 0.1 16 56419902 _EBL26 AMFR 164.13 45.49 0.053 16 67477072 _EBL26 ATP6V0D1 23.68 135.75 0.123 18 5291099 _EBL26 ZBTB14 197.51 12.21 0.071 19 19758056 _EBL26 ATP13A1 33.21 19.62 0.061 19 19767849 _EBL26 ATP13A1 47.13 19.62 0.068 2 37078169 _EBL26 STRN 235.65 10.01 0.065 2 220089170 _EBL26 ATG9A 107.56 30.87 0.059 20 20024245 _EBL26 CRNKL1 112.84 20.93 0.072 21 38437997 _EBL26 PIGP 409.17 45.62 0.09 22 29092932 _EBL26 CHEK2 214.22 13.15 0.107 3 36893298 _EBL26 TRANK1 125.94 16.98 0.25 3 52588824 _EBL26 PBRM1 181.21 13.44 0.129 3 56694766 _EBL26 FAM208A 80.08 15.68 0.125 3 132166250 _EBL26 DNAJC13 181.69 21.36 0.1 3 141692955 _EBL26 TFDP2 29.97 10.39 0.103 3 171443809 _EBL26 PLD1 47.32 27.27 0.061 3 180675619 _EBL26 FXR1 81.43 18.15 0.068 3 182810260 _EBL26 MCCC1 34.36 35.5 0.131 4 42454006 _EBL26 ATP8A1 41.33 33.22 0.054 5 94872769 _EBL26 TTC37 16.26 40.76 0.057 6 43020177 _EBL26 CUL7 40.32 11 0.15 7 16685134 _EBL26 ANKMY2 116.86 28.34 0.081 8 126056809 _EBL26 KIAA0196 126.92 31.27 0.059 X 62875440 _EBL26 ARHGEF9 8.67 10.18 0.075 X 96013177 _EBL26 DIAPH2 75.93 11.77 0.207 X 154741338 _EBL26 TMLHE 202.89 18.16 0.115 1 44126021 _EBL3 KDM4A 193.09 23.63 0.074 10 15256263 _EBL3 FAM171A1 274.52 19.68 0.078

10 81036968 _EBL3 ZMIZ1 204.39 11.75 0.111 12 7048134 _EBL3 ATN1 79.73 16.12 0.061 12 71139785 _EBL3 PTPRR 83.82 24.37 0.057 12 107371883 _EBL3 MTERFD3 230.63 13.77 0.129 14 92621581 _EBL3 CPSF2 252.93 15 0.123 16 28847378 _EBL3 ATXN2L 18.26 19.17 0.083 16 56531665 _EBL3 BBS2 321.76 20.4 0.065 16 67477072 _EBL3 ATP6V0D1 32.62 145.32 0.057 17 15878187 _EBL3 ADORA2B 52.19 24.38 0.056 17 27182148 _EBL3 ERAL1 107.33 50.5 0.065 18 47110043 _EBL3 LIPG 484.46 10.92 0.075 19 886032 _EBL3 MED16 161.44 20.64 0.188 19 42402722 _EBL3 ARHGEF1 72.6 22.61 0.08 2 27601679 _EBL3 ZNF513 150.46 20.01 0.103 2 97377608 _EBL3 LMAN2L 226.58 12.82 0.103 3 133375600 _EBL3 TOPBP1 139.44 10.85 0.217 4 152070653 _EBL3 SH3D19 263.29 35.35 0.06 4 184572187 _EBL3 RWDD4 324.86 20.02 0.051 4 190881969 _EBL3 FRG1 264.76 58.36 0.062 5 36170455 _EBL3 SKP2 78.26 14.74 0.241 5 143538021 _EBL3 YIPF5 26.97 33.12 0.115 6 31762847 _EBL3 VARS 217.87 20.87 0.19 6 131917102 _EBL3 MED23 367.79 11.37 0.133 8 52773435 _EBL3 PCMTD1 156.04 19.68 0.051 8 68139407 _EBL3 ARFGEF1 66.62 12.03 0.15 9 115449822 _EBL3 INIP 450.75 18.67 0.058 X 149814229 _EBL3 MTM1 96.76 18.06 0.063 1 182827981 _EBL5 DHX9 236.85 28.77 0.068 1 220978440 _EBL5 1-Mar 28.43 24.17 0.054 10 104857062 _EBL5 NT5C2 111.55 21.58 0.073 12 6966847 _EBL5 USP5 64.69 20.45 0.103

16 2025679 _EBL5 TBL3 13.49 10.17 0.111 17 36958403 _EBL5 CWC25 26.37 10.53 0.128 18 47500759 _EBL5 MYO5B 241.53 23.19 0.063 19 40947803 _EBL5 SERTAD3 48.34 25.84 0.064 2 114218256 _EBL5 CBWD2 182.5 29.31 0.071 2 201749994 _EBL5 PPIL3 219.04 32.94 0.333 3 145828134 _EBL5 PLOD2 144.73 14.79 0.069 3 169566007 _EBL5 LRRC31 96.75 27.36 0.056 6 13306706 _EBL5 TBC1D7 54.43 23.93 0.062 9 100895361 _EBL5 CORO2A 175.96 14.8 0.083 1 21181546 _EBL7 EIF4G3 114.88 36.83 0.113 1 42654475 _EBL7 FOXJ3 154.34 27.37 0.066 10 103344393 _EBL7 POLL 173.19 16.33 0.111 11 57080249 _EBL7 TNKS1BP1 94.38 33.65 0.059 11 108412459 _EBL7 EXPH5 259.52 12.22 0.25 12 21629850 _EBL7 RECQL 52.17 13.31 0.125 12 72025969 _EBL7 ZFC3H1 119.86 18.41 0.2 12 107391764 _EBL7 CRY1 137.09 10.14 0.192 12 113436141 _EBL7 OAS2 103.14 10.66 0.286 12 124233229 _EBL7 ATP6V0A2 98.21 11.16 0.243 14 93720040 _EBL7 BTBD7 164.54 15.48 0.091 15 35176905 _EBL7 AQR 211.45 21.2 0.059 15 52901139 _EBL7 FAM214A 447.26 21.59 0.08 15 77473399 _EBL7 PEAK1 57.97 14.76 0.176 16 15698092 _EBL7 KIAA0430 163.66 27.17 0.051 17 43192550 _EBL7 PLCD3 83.72 147.09 0.071 17 55027396 _EBL7 COIL 406.42 17.24 0.15 17 74739518 _EBL7 MFSD11 124.82 22.71 0.071 17 80888479 _EBL7 TBCD 60.35 21.36 0.068 18 12794281 _EBL7 PTPN2 84.13 31.17 0.139 19 4054678 _EBL7 ZBTB7A 105.82 40.83 0.074

19 10602527 _EBL7 KEAP1 91.57 46.78 0.063 2 42909652 _EBL7 MTA3 115.87 24.73 0.06 2 86849950 _EBL7 RNF103 52.35 68.34 0.053 2 176857119 _EBL7 KIAA1715 109.67 20.15 0.103 20 30914609 _EBL7 KIF3B 170.03 34.71 0.095 3 197023258 _EBL7 DLG1 154.58 38.2 0.052 4 89326751 _EBL7 HERC6 174.68 11.19 0.192 4 187000145 _EBL7 TLR3 136.22 20.2 0.122 4 187629945 _EBL7 FAT1 147.41 37.68 0.093 5 205801 _EBL7 CCDC127 239.66 15.48 0.118 5 16794906 _EBL7 MYO10 96.34 25.5 0.061 5 80600740 _EBL7 ZCCHC9 102.43 25.68 0.085 6 17608468 _EBL7 FAM8A1 137.23 41.66 0.08 6 34574585 _EBL7 C6orf106 321.45 42.14 0.053 6 36294836 _EBL7 C6orf222 123.74 16.18 0.093 6 99347304 _EBL7 FBXL4 111.78 11.32 0.125 6 139101021 _EBL7 CCDC28A 162.96 24 0.062 7 1514377 _EBL7 INTS1 74.38 31.23 0.052 7 2278515 _EBL7 FTSJ2 451.03 21.47 0.158 7 92140905 _EBL7 PEX1 105.03 20.46 0.105 8 87460494 _EBL7 WWP1 197.69 30.64 0.069 9 123538378 _EBL7 FBXW2 129.86 18.09 0.091 9 135202094 _EBL7 SETX 453.08 18.16 0.109 X 129208564 _EBL7 ELF4 328.99 44.81 0.138 1 977467 _EBL9 AGRN 141.95 28.78 0.135 1 1231863 _EBL9 ACAP3 201.04 19.43 0.365 1 1271642 _EBL9 DVL1 17.48 54.3 0.286 1 1455550 _EBL9 ATAD3A 74.32 33.73 0.211 1 1571750 _EBL9 CDK11B 12.05 76.18 0.32 1 2235424 _EBL9 SKI 93.72 20.89 0.378 1 11854035 _EBL9 MTHFR 286.29 15.18 0.082

1 11855218 _EBL9 MTHFR 20.69 15.18 0.081 1 12343399 _EBL9 VPS13D 20.66 13.79 0.087 1 16043236 _EBL9 PLEKHM2 5.61 26.95 0.25 1 16456779 _EBL9 EPHA2 23.31 21.07 0.27 1 16475182 _EBL9 EPHA2 44.35 21.07 0.13 1 17349144 _EBL9 SDHB 71.17 211.43 0.374 1 21100060 _EBL9 HP1BP3 12.35 89.2 0.053 1 22050473 _EBL9 USP48 9.49 39.19 0.075 1 22056218 _EBL9 USP48 14.93 39.19 0.063 1 22078035 _EBL9 USP48 43.25 39.19 0.055 1 22149931 _EBL9 HSPG2 22.19 27.75 0.059 1 24297760 _EBL9 SRSF10 248.25 108.75 0.333 1 27736317 _EBL9 WASF2 7.1 76.25 0.231 1 33245822 _EBL9 YARS 91.97 38.61 0.294 1 33408010 _EBL9 RNF19B 12.01 42.04 0.053 1 44424161 _EBL9 IPO13 14.04 15.44 0.449 1 46485343 _EBL9 MAST2 4.23 39.35 0.217 1 51436084 _EBL9 CDKN2C 10.52 16.91 0.113 1 62350067 _EBL9 INADL 7.32 29.41 0.129 1 78479071 _EBL9 DNAJB4 10.5 13.42 0.349 1 109200117 _EBL9 HENMT1 13.38 27.94 0.087 1 117529557 _EBL9 PTGFRN 43.82 42.02 0.167 1 146631149 _EBL9 PRKAB2 16.01 18.76 0.111 1 151149169 _EBL9 VPS72 150.8 38.61 0.071 1 151849494 _EBL9 THEM4 17.25 10.54 0.051 1 161180395 _EBL9 NDUFS2 34.85 146.51 0.341 1 166815941 _EBL9 POGK 97.56 33.72 0.052 1 180849235 _EBL9 XPR1 14.84 12.11 0.063 1 208390403 _EBL9 PLXNA2 43.74 18.61 0.07 1 211749518 _EBL9 SLC30A1 5.21 22.76 0.227 1 226016576 _EBL9 EPHX1 400.35 81.22 0.333

1 235298999 _EBL9 RBM34 11.16 45.51 0.069 1 236148745 _EBL9 NID1 76.39 21.02 0.053 1 236208941 _EBL9 NID1 14.21 21.02 0.154 10 24873399 _EBL9 ARHGAP21 15.57 33.44 0.092 10 24873775 _EBL9 ARHGAP21 39.88 33.44 0.272 10 69565358 _EBL9 DNAJC12 272.98 40.27 0.054 10 97192222 _EBL9 SORBS1 111.92 21.15 0.118 10 97919840 _EBL9 ZNF518A 7.43 19.13 0.176 10 104157133 _EBL9 NFKB2 3.63 25.01 0.08 10 112337669 _EBL9 SMC3 33.05 49.66 0.102 10 112724670 _EBL9 SHOC2 14.18 34.66 0.167 10 115608814 _EBL9 DCLRE1A 119.02 10.72 0.107 10 120917400 _EBL9 SFXN4 17.63 38.6 0.056 10 121595149 _EBL9 MCMBP 24.11 36.27 0.061 10 129903635 _EBL9 MKI67 40.76 32.6 0.062 10 129905485 _EBL9 MKI67 67.33 32.6 0.133 11 721688 _EBL9 EPS8L2 22.84 146.22 0.279 11 3380754 _EBL9 ZNF195 10.92 14.94 0.163 11 9864229 _EBL9 SBF2 11.66 21.67 0.108 11 46818415 _EBL9 CKAP5 11.46 39.79 0.114 11 57188468 _EBL9 SLC43A3 8.66 14.3 0.091 11 61096912 _EBL9 DDB1 103.9 114.89 0.14 11 61544854 _EBL9 MYRF 43.62 31.56 0.265 11 62482788 _EBL9 HNRNPUL2 263.36 56.88 0.058 11 63667450 _EBL9 MARK2 96.21 43.13 0.136 11 64025966 _EBL9 PLCB3 16.26 55.67 0.337 11 64600378 _EBL9 CDC42BPG 71.44 25.31 0.317 11 64645826 _EBL9 EHD1 7.29 45.73 0.172 11 64863915 _EBL9 VPS51 55.27 63.65 0.068 11 65413964 _EBL9 SIPA1 12.32 17.15 0.081 11 65836146 _EBL9 SF3B2 46.82 128.48 0.08

11 67259691 _EBL9 PITPNM1 25.15 30.15 0.351 11 94918428 _EBL9 SESN3 122.52 23.02 0.095 11 102248421 _EBL9 BIRC2 27.97 46.36 0.051 11 111594812 _EBL9 SIK2 252.7 16.13 0.133 11 114578217 _EBL9 NXPE2 49.29 23.83 0.125 11 118925327 _EBL9 HYOU1 9.2 76.89 0.104 11 118971735 _EBL9 DPAGT1 8.97 34.89 0.06 11 119003698 _EBL9 HINFP 28.68 18.2 0.111 11 128844190 _EBL9 ARHGAP32 26.5 33.27 0.088 12 442679 _EBL9 KDM5A 17.95 14.58 0.098 12 475171 _EBL9 KDM5A 34.5 14.58 0.12 12 6438503 _EBL9 TNFRSF1A 13.66 97.91 0.143 12 12673821 _EBL9 DUSP16 10.8 31.79 0.065 12 26580923 _EBL9 ITPR2 8.64 16.37 0.069 12 31448226 _EBL9 FAM60A 6.12 44.49 0.095 12 33049512 _EBL9 PKP2 5.53 81.59 0.069 12 52306904 _EBL9 ACVRL1 208.68 92.09 0.283 12 53467129 _EBL9 SPRYD3 137.57 40.38 0.101 12 56347514 _EBL9 DGKA 64.32 54.93 0.151 12 56817128 _EBL9 TIMELESS 20.67 23.41 0.07 12 58162792 _EBL9 METTL1 98.1 20.94 0.1 12 62979217 _EBL9 MON2 8.77 14.84 0.079 12 64202861 _EBL9 TMEM5 27.73 20.26 0.214 12 69260684 _EBL9 CPM 37.27 21.54 0.065 12 75889439 _EBL9 GLIPR1 342.78 11.17 0.1 12 120608090 _EBL9 GCN1L1 36.12 37.98 0.051 12 122724459 _EBL9 VPS33A 275.74 22.27 0.061 12 123800204 _EBL9 SBNO1 36.21 15.6 0.254 13 26788166 _EBL9 RNF6 86.2 35.68 0.088 13 28537278 _EBL9 CDX2 134.74 103.94 0.172 13 41134954 _EBL9 FOXO1 7.67 12.75 0.159

13 42306241 _EBL9 VWA8 55.84 15.57 0.1 13 43462513 _EBL9 EPSTI1 4.03 14.75 0.068 13 77589604 _EBL9 FBXL3 28.09 32.68 0.093 13 79940860 _EBL9 RBM26 21.84 24.89 0.123 14 20864059 _EBL9 TEP1 5.81 24.58 0.093 14 23549379 _EBL9 ACIN1 6.02 93.46 0.109 14 24761878 _EBL9 DHRS1 35.66 38.48 0.067 14 24884470 _EBL9 NYNRIN 19.61 21.19 0.329 14 24885568 _EBL9 NYNRIN 14.71 21.19 0.405 14 45675309 _EBL9 MIS18BP1 20.49 15.85 0.087 14 51233032 _EBL9 NIN 159.27 15.75 0.211 14 55817461 _EBL9 FBXO34 10.28 67.89 0.069 14 61952305 _EBL9 PRKCH 5.55 12.06 0.1 14 69376696 _EBL9 ACTN1 24.53 68.29 0.051 14 75265068 _EBL9 YLPM1 280.06 17.5 0.23 14 75528445 _EBL9 ACYP1 135.87 30.51 0.176 14 91760521 _EBL9 CCDC88C 8.8 21.07 0.106 14 95573991 _EBL9 DICER1 32.43 29.4 0.068 15 35275295 _EBL9 ZNF770 11.24 23.27 0.052 15 40512918 _EBL9 BUB1B 14.43 16.53 0.1 15 44856787 _EBL9 SPG11 9.63 33.07 0.056 15 49325188 _EBL9 SECISBP2L 96.37 18.75 0.261 15 52515757 _EBL9 MYO5C 243.04 45.99 0.076 15 59964846 _EBL9 BNIP2 18.25 26.96 0.081 15 63948040 _EBL9 HERC1 11.92 14.37 0.081 15 64669047 _EBL9 KIAA0101 72.89 23.47 0.066 15 70971963 _EBL9 UACA 182.77 21.4 0.066 16 427044 _EBL9 TMEM8A 27.37 77.44 0.053 16 570188 _EBL9 RAB11FIP3 37.16 22.87 0.152 16 711894 _EBL9 WDR90 29.81 10.21 0.2 16 1867176 _EBL9 HAGH 15.57 41.18 0.053

16 2126131 _EBL9 TSC2 8.04 37.49 0.234 16 2147162 _EBL9 PKD1 22.93 20.29 0.107 16 3828120 _EBL9 CREBBP 79.82 20.92 0.214 16 4659804 _EBL9 UBALD1 10.08 12.93 0.3 16 11785542 _EBL9 TXNDC11 15.3 58.72 0.065 16 24583471 _EBL9 RBBP6 108.53 24.71 0.325 16 29856073 _EBL9 MVP 95.6 365.36 0.235 16 67227020 _EBL9 E2F4 39.59 85.09 0.078 16 70531851 _EBL9 COG4 10.47 47.03 0.096 16 89217537 _EBL9 ACSF3 3.88 20.39 0.158 16 90001977 _EBL9 TUBB3 21.77 10.02 0.226 17 3851056 _EBL9 ATP2A3 18.86 204.38 0.093 17 3967806 _EBL9 ZZEF1 11.07 33.84 0.069 17 3977491 _EBL9 ZZEF1 8.14 33.84 0.07 17 4439660 _EBL9 SPNS2 35.94 14.22 0.128 17 4793023 _EBL9 MINK1 171.21 104.25 0.341 17 5292210 _EBL9 NUP88 249.78 38.33 0.059 17 7287344 _EBL9 TNK1 12.99 16.45 0.294 17 7760107 _EBL9 MD1 7.04 85.56 0.069 17 7798765 _EBL9 CHD3 262.86 36.2 0.157 17 8092505 _EBL9 C17orf59 13.84 12.72 0.174 17 17719648 _EBL9 SREBF1 24.7 34.24 0.169 17 26495598 _EBL9 NLK 23.66 12.13 0.233 17 29632041 _EBL9 EVI2B 4.79 37.61 0.083 17 30692357 _EBL9 ZNF207 193.85 132.34 0.262 17 34883510 _EBL9 MYO19 20.4 44.33 0.344 17 37881332 _EBL9 ERBB2 9.99 176.97 0.265 17 39981827 _EBL9 NT5C3B 64.61 34.03 0.067 17 40257879 _EBL9 DHX58 5.12 10.02 0.1 17 40948220 _EBL9 WNK4 7.34 43.13 0.229 17 42170688 _EBL9 HDAC5 11.15 17.79 0.107

17 43531117 _EBL9 PLEKHM1 21.99 26.76 0.121 17 58035801 _EBL9 RNFT1 16.34 20.5 0.16 17 58541426 _EBL9 APPBP2 20.03 15.12 0.089 17 76134212 _EBL9 TMC8 2.86 12.49 0.102 17 79990681 _EBL9 RAC3 187.17 19.68 0.079 17 80042545 _EBL9 FASN 37.3 31.76 0.081 18 210479 _EBL9 USP14 44.91 27.92 0.052 18 5423410 _EBL9 EPB41L3 17.44 27.07 0.063 18 12325093 _EBL9 TUBB6 37.21 21.15 0.14 18 18625344 _EBL9 ROCK1 169.04 26.31 0.059 18 29412058 _EBL9 TRAPPC8 77.26 19.6 0.085 19 625190 _EBL9 POLRMT 45.67 24.28 0.109 19 990868 _EBL9 WDR18 37.67 33.71 0.2 19 1255534 _EBL9 MIDN 3.65 50.87 0.098 19 1828066 _EBL9 REXO1 10.09 18.48 0.429 19 1979174 _EBL9 CSNK1G2 103.68 44.56 0.242 19 4328730 _EBL9 STAP2 65.52 133.91 0.311 19 7747413 _EBL9 TRAPPC5 14.85 74.7 0.288 19 9721589 _EBL9 ZNF561 65.15 14.17 0.107 19 10202178 _EBL9 C19orf66 11.28 25.87 0.225 19 10439688 _EBL9 RAVER1 34.75 41.48 0.175 19 10662583 _EBL9 ATG4D 116.71 27.62 0.153 19 11144026 _EBL9 SMARCA4 140.67 51.18 0.142 19 13051678 _EBL9 CALR 79.65 891.28 0.134 19 13216116 _EBL9 TRMT1 34.18 31.88 0.108 19 13247130 _EBL9 NACC1 11.8 36.3 0.244 19 14581010 _EBL9 PKN1 323.9 26.51 0.1 19 23544208 _EBL9 ZNF91 9.82 28.94 0.064 19 33095294 _EBL9 ANKRD27 23.68 28.49 0.15 19 33137391 _EBL9 ANKRD27 11.75 28.49 0.083 19 35232224 _EBL9 ZNF181 14.09 12.12 0.176

19 35769607 _EBL9 USF2 435.1 90.22 0.068 19 40411811 _EBL9 FCGBP 26.79 208.35 0.102 19 45496046 _EBL9 CLPTM1 228.65 87 0.301 19 46375988 _EBL9 FOXA3 9.7 42.7 0.104 19 49134196 _EBL9 DBP 22.47 13.29 0.333 19 50059812 _EBL9 NOSIP 21.83 75.36 0.367 19 50155915 _EBL9 SCAF1 27.77 18.74 0.111 19 50166696 _EBL9 IRF3 21.4 67.78 0.079 19 52448812 _EBL9 ZNF613 220.2 11.47 0.19 19 54631554 _EBL9 PRPF31 38.18 45.11 0.25 19 54969678 _EBL9 LENG8 4.81 96.25 0.092 19 55789019 _EBL9 HSPBP1 8.66 42.31 0.057 19 56156449 _EBL9 ZNF581 146.29 17.03 0.292 2 10799303 _EBL9 NOL10 10.72 19.01 0.095 2 15534390 _EBL9 NBAS 4.38 15.5 0.241 2 43452248 _EBL9 ZFP36L2 18.01 206.32 0.162 2 46808174 _EBL9 RHOQ 3.67 19.66 0.088 2 48026462 _EBL9 MSH6 10.25 30.73 0.085 2 54101570 _EBL9 PSME4 14.64 18.72 0.094 2 55470668 _EBL9 MTIF2 4.43 55.73 0.057 2 55863406 _EBL9 PNPT1 13.28 22.56 0.136 2 61441772 _EBL9 USP34 4.67 25.92 0.163 2 75897272 _EBL9 GCFC2 96.16 11.01 0.235 2 95943250 _EBL9 PROM2 27.51 27.12 0.094 2 96955545 _EBL9 SNRNP200 64.46 98.75 0.055 2 112863638 _EBL9 TMEM87B 61.86 38.03 0.091 2 120979753 _EBL9 TMEM185B 8.04 12.96 0.065 2 120980180 _EBL9 TMEM185B 9.19 12.96 0.339 2 159490705 _EBL9 PKP4 43.9 37.38 0.052 2 160735816 _EBL9 LY75 15.35 29.84 0.053 2 170460570 _EBL9 PPIG 67.2 62.16 0.29

2 230675881 _EBL9 TRIP12 181.13 51.12 0.155 2 235950297 _EBL9 SH3BP4 15.42 28.09 0.391 20 18118652 _EBL9 PET117 33.93 18.49 0.344 20 20592041 _EBL9 RALGAPA2 8.04 35.04 0.09 20 30897620 _EBL9 KIF3B 11.19 36.43 0.247 20 32247356 _EBL9 NECAB3 388.68 25.7 0.4 20 33623034 _EBL9 TRPC4AP 23.22 68.31 0.055 20 34451002 _EBL9 PHF20 84.58 13.24 0.222 20 43243243 _EBL9 PKIG 290.83 64.79 0.157 20 49509089 _EBL9 ADNP 22.23 39.08 0.097 20 62192460 _EBL9 HELZ2 154.48 10.41 0.056 21 34117929 _EBL9 PAXBP1 28.13 27.45 0.056 21 34889364 _EBL9 GART 10.06 47.42 0.086 21 37612076 _EBL9 DOPEY2 11.48 23.16 0.125 21 42817982 _EBL9 MX1 5.28 24.68 0.065 21 43711228 _EBL9 ABCG1 10.52 23.71 0.106 22 21333587 _EBL9 AIFM3 24.34 35.25 0.089 22 21984001 _EBL9 YDJC 74.52 18.86 0.471 22 22294047 _EBL9 PPM1F 11.28 12.47 0.175 22 23634785 _EBL9 BCR 5.77 24.86 0.296 22 36701983 _EBL9 MYH9 8.73 335.27 0.057 22 38894446 _EBL9 DDX17 5.3 220.77 0.241 22 50217295 _EBL9 BRD1 425.96 20.64 0.063 22 50659306 _EBL9 TUBGCP6 43.9 22.16 0.061 22 50716563 _EBL9 PLXNB2 11.08 153.08 0.106 22 51063643 _EBL9 ARSA 151.61 30.06 0.053 3 10123118 _EBL9 FANCD2 14.65 14.4 0.074 3 13363302 _EBL9 NUP210 15.33 22.46 0.26 3 45136908 _EBL9 CDCP1 31.1 39.75 0.074 3 50009556 _EBL9 RBM6 15.02 61.45 0.065 3 58120468 _EBL9 FLNB 68.75 171.3 0.077

3 69077385 _EBL9 TMF1 422.17 26.57 0.093 3 81586108 _EBL9 GBE1 33.54 12.26 0.132 3 98300326 _EBL9 CPOX 42.32 23.5 0.053 3 107938267 _EBL9 IFT57 20.09 32.58 0.063 3 110852822 _EBL9 PVRL3 70.21 42.45 0.211 3 113218377 _EBL9 SPICE1 22.28 11.34 0.079 3 121417268 _EBL9 GOLGB1 43.04 52.1 0.065 3 127965882 _EBL9 EEFSEC 6.09 17.53 0.395 3 131188575 _EBL9 MRPL3 373.75 101.53 0.248 3 148768078 _EBL9 HLTF 111.14 15.47 0.125 3 169587433 _EBL9 LRRC31 72.6 41.43 0.056 3 172115129 _EBL9 FNDC3B 6.96 32.87 0.056 3 183885810 _EBL9 DVL3 8.5 35.49 0.207 3 184294687 _EBL9 EPHB3 338.91 81.37 0.073 4 955618 _EBL9 DGKQ 17.02 34.7 0.338 4 960297 _EBL9 DGKQ 20.61 34.7 0.161 4 2934900 _EBL9 MFSD10 22.89 40.13 0.194 4 48567607 _EBL9 FRYL 30.06 51.86 0.066 4 79793027 _EBL9 BMP2K 72.5 20.81 0.065 4 113353595 _EBL9 ALPK1 9.28 12.71 0.138 4 122723894 _EBL9 EXOSC9 5.69 22.91 0.128 4 146071684 _EBL9 OTUD4 37.79 21.96 0.061 4 149075933 _EBL9 NR3C2 252.56 41.31 0.071 4 156850771 _EBL9 CTSO 147.17 30.12 0.059 4 187549341 _EBL9 FAT1 76.87 58.85 0.067 5 306758 _EBL9 PDCD6 55.31 182.19 0.324 5 10430040 _EBL9 6-Mar 27.85 39.52 0.297 5 14488280 _EBL9 TRIO 181.52 24.1 0.226 5 16465696 _EBL9 ZNF622 8.34 54.44 0.103 5 33461120 _EBL9 TARS 26.38 73.35 0.059 5 36985591 _EBL9 NIPBL 7.76 22.28 0.091

5 60050576 _EBL9 ELOVL7 40.01 24.32 0.059 5 71533860 _EBL9 MRPS27 29.08 57.35 0.077 5 72851344 _EBL9 ANKRA2 12.51 16.43 0.104 5 74041570 _EBL9 GFM2 180.49 24.57 0.122 5 74685424 _EBL9 COL4A3BP 242.69 19.47 0.118 5 76745613 _EBL9 WDR41 39.61 18.65 0.08 5 79933757 _EBL9 DHFR 52.66 73.04 0.065 5 95226836 _EBL9 ELL2 7.76 12.28 0.1 5 95234316 _EBL9 ELL2 68.3 12.28 0.054 5 96512898 _EBL9 RIOK2 23.51 17.26 0.054 5 130721248 _EBL9 CDC42SE2 121.49 88.37 0.218 5 140957846 _EBL9 DIAPH1 459.2 50.12 0.062 5 156746887 _EBL9 CYFIP2 17.62 20.05 0.267 5 162870695 _EBL9 CCNG1 20.34 132.96 0.161 5 176942036 _EBL9 DDX41 16.31 73.15 0.053 5 177569638 _EBL9 RMND5B 11.2 32.59 0.233 6 30154180 _EBL9 TRIM26 83.53 46.44 0.066 6 31516168 _EBL9 NFKBIL1 12.25 21.26 0.138 6 31595663 _EBL9 PRRC2A 20.64 63.91 0.234 6 31852720 _EBL9 EHMT2 5.46 27.11 0.098 6 31926206 _EBL9 NELFE 5.79 84.3 0.41 6 34214562 _EBL9 C6orf1 125.77 18.21 0.053 6 39162413 _EBL9 KCNK5 10.08 23.33 0.152 6 42797450 _EBL9 GLTSCR1L 90.09 13.57 0.2 6 42937639 _EBL9 PEX6 8.22 19.3 0.2 6 42946341 _EBL9 PEX6 8.38 19.3 0.109 6 43639557 _EBL9 MRPS18A 24.95 90.89 0.109 6 44358024 _EBL9 CDC5L 12.12 24.3 0.067 6 99374699 _EBL9 FBXL4 78.76 15.05 0.111 6 116599823 _EBL9 TSPYL1 121.48 44.41 0.062 6 151766570 _EBL9 RMND1 2.84 21.64 0.091

6 153311172 _EBL9 MTRF1L 205.2 23.52 0.172 7 17931170 _EBL9 SNX13 14.57 23.47 0.083 7 17937003 _EBL9 SNX13 35.63 23.47 0.125 7 34977669 _EBL9 DPY19L1 4.63 17.98 0.068 7 35053220 _EBL9 DPY19L1 6.61 17.98 0.091 7 44112783 _EBL9 POLM 257.73 17.08 0.081 7 45140880 _EBL9 TBRG4 3.53 78.71 0.312 7 50534962 _EBL9 DDC 147.18 50.65 0.057 7 51095806 _EBL9 COBL 119.2 24.04 0.207 7 72892029 _EBL9 BAZ1B 59.8 38.34 0.071 7 76112243 _EBL9 DTX2 3.8 26.95 0.133 7 92765181 _EBL9 SAMD9L 52.32 13.34 0.068 7 92883212 _EBL9 CCDC132 14.54 15.11 0.261 7 100488847 _EBL9 ACHE 44.92 17.52 0.292 7 100642161 _EBL9 MUC12 29.42 525.87 0.848 7 102106398 _EBL9 LRWD1 19.46 13.28 0.28 7 111161406 _EBL9 IMMP2L 17.52 10.06 0.078 7 124499075 _EBL9 POT1 31.57 10.93 0.125 7 143002054 _EBL9 CASP2 15.09 31.36 0.333 7 150730730 _EBL9 ABCB8 3.23 11.68 0.253 7 157174982 _EBL9 DNAJB6 156.52 95.14 0.306 8 22267579 _EBL9 SLC39A14 5.43 107.13 0.06 8 30510988 _EBL9 GTF2E2 100.86 29.19 0.229 8 41794936 _EBL9 KAT6A 177.26 15.89 0.079 8 59508137 _EBL9 NSMAF 16.89 25.75 0.1 8 61765468 _EBL9 CHD7 10.46 10.04 0.286 8 62460647 _EBL9 ASPH 52.01 100.53 0.069 8 68163640 _EBL9 ARFGEF1 37.86 35 0.078 8 74529570 _EBL9 STAU2 41.23 24.13 0.075 8 82591413 _EBL9 IMPA1 95.76 24.23 0.086 8 125506080 _EBL9 TATDN1 12.1 31.79 0.094

8 134488056 _EBL9 ST3GAL1 15.07 12.92 0.138 8 141810636 _EBL9 PTK2 32.06 47.62 0.051 8 145111352 _EBL9 OPLAH 55.33 19.32 0.104 8 145623823 _EBL9 CPSF1 36.34 55.01 0.291 9 152043 _EBL9 CBWD1 8.98 16.98 0.5 9 5732473 _EBL9 KIAA1432 10.64 11.98 0.3 9 5968945 _EBL9 KIAA2026 26.97 10.3 0.167 9 19346207 _EBL9 DENND4C 5.11 29.02 0.065 9 20365672 _EBL9 MLLT3 47.43 28.95 0.085 9 74332933 _EBL9 TMEM2 30.84 53.23 0.056 9 77455075 _EBL9 TRPM6 13.44 18.5 0.115 9 95030500 _EBL9 IARS 41.91 64.53 0.082 9 100437746 _EBL9 XPA 81.41 13.76 0.167 9 101589145 _EBL9 GALNT12 10.13 104.19 0.179 9 110248156 _EBL9 KLF4 100.85 143.31 0.062 9 116021054 _EBL9 SLC31A1 21.5 32.13 0.291 9 119461106 _EBL9 TRIM32 13.78 11.61 0.273 9 124118368 _EBL9 STOM 39.88 19.91 0.091 9 125923305 _EBL9 STRBP 4.68 22.45 0.055 9 130869309 _EBL9 SLC25A25 6.75 18.31 0.194 9 130984829 _EBL9 DNM1 10.54 13.42 0.567 9 134021644 _EBL9 NUP214 40.64 27.68 0.263 9 134090719 _EBL9 NUP214 16.27 27.68 0.051 9 134458025 _EBL9 RAPGEF1 7.07 29.09 0.055 9 135173640 _EBL9 SETX 52.42 21.19 0.083 X 3544497 _EBL9 PRKX 15.47 20.22 0.058 X 7252131 _EBL9 STS 18.41 14.83 0.178 X 39923638 _EBL9 BCOR 12.15 17.63 0.159 X 39932396 _EBL9 BCOR 23.46 17.63 0.073 X 54043077 _EBL9 PHF8 178.11 16.67 0.095 X 76937083 _EBL9 ATRX 199.55 17.23 0.167

X 100667661 _EBL9 HNRNPH2 13.4 49.82 0.051 X 106890852 _EBL9 PRPS1 8.98 23.03 0.103 X 114864240 _EBL9 P3 58.51 26.96 0.089 X 131516211 _EBL9 MBNL3 50.08 11.86 0.111 X 152959811 _EBL9 SLC6A8 15.72 110.6 0.454 X 152981045 _EBL9 BCAP31 4.65 310.72 0.27 1 11182058 _T1 MTOR 201.94 17.92 0.079 1 39854317 _T1 MACF1 278.75 38.27 0.133 1 46655596 _T1 POMGNT1 405.24 29.79 0.078 1 156252454 _T1 SMG5 15.26 21.54 0.267 1 162769548 _T1 HSD17B7 107.45 29.33 0.083 1 220162105 _T1 EPRS 92.03 43.79 0.083 10 89692979 _T1 PTEN 133.67 17.81 0.474 10 89717719 _T1 PTEN 296.41 17.81 0.299 11 6629392 _T1 ILK 63.4 75.69 0.077 11 9983535 _T1 SBF2 80.84 10.46 0.435 11 62496412 _T1 TTC9C 92.64 16.17 0.068 12 46321734 _T1 SCAF11 389.93 10.91 0.111 12 72036265 _T1 ZFC3H1 380.95 18.42 0.409 12 99042471 _T1 APAF1 195.59 10.78 0.407 12 121783822 _T1 ANAPC5 35.94 27.53 0.386 12 133249803 _T1 POLE 66.36 12 0.071 13 103266498 _T1 TPP2 40.17 13.7 0.071 13 103292625 _T1 TPP2 167.98 13.7 0.528 13 114288254 _T1 TFDP1 59.59 22.41 0.456 14 64612875 _T1 SYNE2 92.95 31.28 0.58 14 69256455 _T1 ZFP36L1 64.92 16.07 0.366 14 77935551 _T1 AHSA1 353.2 109.17 0.082 14 102505502 _T1 DYNC1H1 159.17 137.77 0.276 16 29465368 _T1 BOLA2 81.38 158.48 0.138 16 31049934 _T1 STX4 111.82 26.6 0.235

16 53515728 _T1 RBL2 37.96 10.88 0.19 16 70400156 _T1 DDX19A 248.98 21.85 0.4 16 74666475 _T1 RFWD3 71.09 12.54 0.275 16 89620217 _T1 SPG7 234.16 32.2 0.066 16 90001221 _T1 TUBB3 473.83 87.55 0.432 17 4619810 _T1 ARRB2 38.55 20.19 0.239 17 15984038 _T1 NCOR1 162.44 35.91 0.211 17 49077049 _T1 SPAG9 478.33 13.72 0.291 17 78355358 _T1 RNF213 275.32 129.82 0.31 18 33800145 _T1 MOCOS 116.01 23.34 0.333 19 40883695 _T1 PLD3 148.54 26.69 0.118 19 45397092 _T1 TOMM40 247.28 14.96 0.435 2 32773057 _T1 BIRC6 200.5 27.91 0.074 2 46608779 _T1 EPAS1 58.82 19.56 0.081 2 99998635 _T1 EIF5B 472.88 49.13 0.476 2 128038115 _T1 ERCC3 119.24 20.07 0.348 2 169699563 _T1 NOSTRIN 215.1 13.17 0.148 20 2633947 _T1 NOP56 94.76 78.19 0.429 21 34924324 _T1 SON 255.17 56.53 0.5 22 24439373 _T1 CABIN1 111.5 28.94 0.422 22 42606271 _T1 TCF20 414.79 13.03 0.286 3 9833114 _T1 TADA3 149.53 15.9 0.403 3 47036795 _T1 NBEAL2 43.64 15.11 0.154 3 69124637 _T1 UBA3 126.22 18.66 0.337 3 110837594 _T1 PVRL3 24.85 10.69 0.213 3 122414425 _T1 PARP14 295.92 73.63 0.073 3 145824354 _T1 PLOD2 246.26 27.68 0.325 3 172046826 _T1 FNDC3B 123.93 26.71 0.056 4 435858 _T1 ZNF721 31.27 14.19 0.44 4 186185626 _T1 SNX25 374.27 13.65 0.38 5 102249702 _T1 PAM 203.57 27.57 0.368

5 131819674 _T1 IRF1 143.77 19.1 0.051 5 141488586 _T1 NDFIP1 76.85 18.93 0.286 6 13321256 _T1 TBC1D7 39.03 15.97 0.204 6 29910371 _T1 HLA-A 462.68 2109.74 0.234 6 33655905 _T1 ITPR3 52.29 37.11 0.086 6 131186705 _T1 EPB41L2 152.58 111.27 0.538 6 143806363 _T1 PEX3 196.69 10.34 0.429 6 151247260 _T1 MTHFD1L 121.29 33.76 0.362 7 50605671 _T1 DDC 431.07 24.32 0.484 8 118847729 _T1 EXT1 184.49 17.96 0.253 8 120793409 _T1 TAF2 55.39 16.26 0.122 8 141407810 _T1 TRAPPC9 51.75 23.41 0.073 8 144941319 _T1 EPPK1 297.62 26.26 0.535 9 35711038 _T1 TLN1 53.96 38.24 0.204 9 106896829 _T1 SMC2 348.21 10.51 0.386 1 16462199 _T2 EPHA2 114.72 14.37 0.122 1 22965632 _T2 C1QA 81.11 20.92 0.06 1 31764761 _T2 SNRNP40 121.8 26.5 0.059 1 32782323 _T2 HDAC1 74.1 68.91 0.524 1 59248285 _T2 JUN 88.67 28.32 0.188 1 89476705 _T2 GBP3 213.66 28.79 0.667 1 150460476 _T2 TARS2 311.66 17.82 0.2 1 154904847 _T2 PMVK 169.23 12.88 0.588 1 186329124 _T2 TPR 137.41 31.57 0.115 1 245021483 _T2 HNRNPU 100.79 58.32 0.5 10 89720812 _T2 PTEN 77.38 18.91 0.322 11 1262542 _T2 MUC5B 65.09 96.14 0.103 11 13736194 _T2 FAR1 60.04 11.35 0.397 11 34112143 _T2 CAPRIN1 16.74 79.47 0.097 11 130066291 _T2 ST14 92.8 95.8 0.319 12 6969641 _T2 USP5 248.4 33.3 0.082

12 14689518 _T2 PLBD1 168.49 17.62 0.485 12 31255383 _T2 DDX11 314.69 24.26 0.067 12 31255384 _T2 DDX11 178.23 24.26 0.067 12 57585199 _T2 LRP1 207.79 41.4 0.07 12 62783404 _T2 USP15 80.91 11.05 0.123 12 99074151 _T2 APAF1 133.78 10.42 0.254 12 112460437 _T2 ERP29 123.15 27.43 0.174 14 21869077 _T2 CHD8 69.54 10.77 0.123 14 21875095 _T2 CHD8 73.37 10.77 0.115 14 50971538 _T2 MAP4K5 134.53 10.73 0.364 14 72128104 _T2 SIPA1L1 381.27 12.01 0.146 14 75367836 _T2 DT 81.81 35.13 0.174 14 91948172 _T2 SMEK1 321.78 12.16 0.086 14 97299907 _T2 VRK1 226.56 37.96 0.128 14 103418907 _T2 CDC42BPB 134.78 13.33 0.125 15 28483285 _T2 HERC2 306.5 13.2 0.11 15 28508208 _T2 HERC2 203.28 13.2 0.237 15 42525427 _T2 TMEM87A 85.95 36.19 0.079 15 70961111 _T2 UACA 119.53 11.39 0.057 15 73547088 _T2 NEO1 222.85 22.92 0.435 16 11984967 _T2 GSPT1 220.4 27.65 0.433 16 18853054 _T2 SMG1 19.25 21.57 0.39 16 28123326 _T2 XPO6 27.84 15.66 0.227 16 28845462 _T2 ATXN2L 361.06 11.21 0.103 16 47727378 _T2 PHKB 113.43 32.8 0.238 16 67477072 _T2 ATP6V0D1 37.55 18.22 0.149 16 69191061 _T2 CIRH1A 18.33 52.52 0.066 16 89337296 _T2 ANKRD11 326.06 30.62 0.444 17 7126528 _T2 ACADVL 63.32 223.5 0.21 17 17717028 _T2 SREBF1 253.49 11 0.115 17 18151059 _T2 FLII 25.28 23.68 0.306

17 18781034 _T2 PRPSAP2 139.42 14.05 0.173 17 26901809 _T2 ALDOC 475.25 35.33 0.472 17 28749817 _T2 CPD 338.43 18.07 0.177 17 30226715 _T2 UTP6 22.16 26.21 0.174 17 38062171 _T2 GSDMB 67.68 19.48 0.071 17 40647674 _T2 ATP6V0A1 20.56 10.72 0.077 17 42429820 _T2 GRN 72.72 92.61 0.293 17 45750506 _T2 KPNB1 144.42 120.22 0.069 17 65353445 _T2 PSMD12 46.06 19.88 0.224 17 65907184 _T2 BPTF 436.23 14.4 0.184 17 74063409 _T2 SRP68 181.91 23.01 0.205 18 28672130 _T2 DSC2 306.83 35.01 0.077 18 46808503 _T2 DYM 71.61 20.47 0.2 19 2123363 _T2 AP3D1 38.23 13.6 0.464 19 4475560 _T2 HDGFRP2 414.48 15.71 0.192 19 5896999 _T2 NDUFA11 42.71 68.3 0.369 19 12849356 _T2 ASNA1 88.33 26.25 0.25 19 17387672 _T2 BABAM1 184.46 25.54 0.077 19 38782575 _T2 SPINT2 112.99 209.19 0.081 19 39959402 _T2 SUPT5H 33.04 27.54 0.056 19 40741918 _T2 AKT2 53.99 12.16 0.055 19 47700504 _T2 SAE1 307.01 27.34 0.252 2 48025788 _T2 MSH6 109.4 30.88 0.062 2 48025790 _T2 MSH6 123.47 30.88 0.073 2 96942849 _T2 SNRNP200 487.48 65.81 0.07 2 150426516 _T2 MMADHC 63.23 43.77 0.056 2 206997717 _T2 NDUFS1 87.03 40.48 0.105 2 223787440 _T2 ACSL3 66.07 11.2 0.081 20 30154065 _T2 HM13 398.83 44.86 0.092 20 35526856 _T2 SAMHD1 22.82 34.84 0.051 22 44547427 _T2 PARVB 223.91 34.31 0.192

3 37045935 _T2 MLH1 119.22 35.66 0.395 3 49050009 _T2 WDR6 41.23 17.19 0.138 3 49051303 _T2 WDR6 19.39 17.19 0.278 3 195508858 _T2 MUC4 102.22 107.8 0.115 4 2514283 _T2 RNF4 159.43 17.94 0.269 4 56290737 _T2 TMEM165 365.88 12.5 0.358 4 76587136 _T2 G3BP2 65.1 37.56 0.163 4 119678889 _T2 SEC24D 446.44 25.68 0.057 4 144469241 _T2 SMARCA5 275.3 21.93 0.164 4 151727449 _T2 LRBA 120.07 19.05 0.213 4 187629070 _T2 FAT1 39.18 58.64 0.186 5 14508359 _T2 TRIO 113.68 15.61 0.311 5 16818245 _T2 MYO10 61 14.47 0.231 5 36995756 _T2 NIPBL 344.69 18.22 0.139 5 52229780 _T2 ITGA1 198.88 18.52 0.071 5 70892139 _T2 MCCC2 133.01 55.28 0.245 5 74655855 _T2 HMGCR 498.79 23.71 0.308 6 27835006 _T2 HIST1H1B 200.97 131.59 0.253 6 117869454 _T2 DCBLD1 389.53 11.49 0.189 6 135300334 _T2 HBS1L 108.95 10.07 0.13 7 98552779 _T2 TRRAP 51.5 10.55 0.375 7 99262879 _T2 CYP3A5 448.81 14.15 0.333 7 100635071 _T2 MUC12 94.57 263.93 0.083 7 100635072 _T2 MUC12 472.7 263.93 0.082 8 48883248 _T2 MCM4 340.42 22 0.057 8 95539270 _T2 KIAA1429 113.92 13.45 0.111 9 34616038 _T2 DCTN3 134.52 18.53 0.136 9 79898557 _T2 VPS13A 21.78 36.23 0.079 9 100845146 _T2 NANS 252.11 68.55 0.295 9 131301957 _T2 GLE1 104.71 20.26 0.073 9 139313089 _T2 PMPCA 78.06 34.03 0.088

9 139403486 _T2 NOTCH1 440.31 11.07 0.079 9 140137523 _T2 TUBB4B 77.05 592.62 0.173 X 23724831 _T2 ACOT9 17.76 19.87 0.667 X 41060361 _T2 USP9X 146.49 47.95 0.066 X 77126322 _T2 MAGT1 83.51 19.04 0.081 1 1254701 _T3 CPSF3L 84.71 13.71 0.437 1 1277511 _T3 DVL1 113.53 15.08 0.487 1 8674712 _T3 RERE 235.88 11.11 0.077 1 8716109 _T3 RERE 477.33 11.11 0.818 1 9809959 _T3 CTN1 444.81 36.51 0.122 1 10331618 _T3 KIF1B 117.44 22.22 0.393 1 12378200 _T3 VPS13D 46.5 21.35 0.27 1 14108560 _T3 PRDM2 20.74 12.95 0.165 1 16767342 _T3 NECAP2 66.61 25.01 0.458 1 16778470 _T3 NECAP2 13.18 25.01 0.277 1 19415317 _T3 UBR4 37.34 45.06 0.412 1 19561641 _T3 EMC1 46.75 14.42 0.069 1 22078094 _T3 USP48 239.21 21.81 0.371 1 25573045 _T3 C1orf63 17.92 17.9 0.328 1 33415211 _T3 RNF19B 35.02 16.86 0.269 1 35657978 _T3 SFPQ 206.17 177.46 0.333 1 44056907 _T3 PTPRF 32.83 28.73 0.733 1 52704042 _T3 ZFYVE9 296.04 15.8 0.423 1 89279305 _T3 PKN2 182.9 25.89 0.429 1 97847999 _T3 DPYD 139.97 49.01 0.067 1 151318741 _T3 RFX5 33.78 21.85 0.852 1 151553496 _T3 TUFT1 173.39 18.23 0.623 1 154192379 _T3 C1orf43 6.98 25.35 0.129 1 156563821 _T3 APOA1BP 141.8 26.83 0.382 1 202911182 _T3 ADIPOR1 14.4 11.55 0.103 1 211840478 _T3 NEK2 21.51 17.85 0.477

1 225600231 _T3 LBR 14.05 22.13 0.108 1 228645493 _T3 HIST3H2A 403.32 110.69 0.313 1 243328698 _T3 CEP170 135.01 16.35 0.143 10 1042148 _T3 GTPBP4 84.99 42.67 0.431 10 27493433 _T3 ACBD5 46.98 38.81 0.506 10 47945421 _T3 FAM21B 49.64 74.45 1 10 70737392 _T3 DDX21 5.99 62.82 0.063 10 75301218 _T3 USP54 44.02 13.28 0.353 10 95275293 _T3 CEP55 275.15 13.2 0.2 10 97385138 _T3 ALDH18A1 10.69 32.56 0.091 10 104136818 _T3 GBF1 22 31.82 0.333 10 115885658 _T3 C10orf118 56.67 19.87 0.55 10 120879897 _T3 FAM45A 14.78 25.56 0.286 10 122650240 _T3 WDR11 50.27 24.34 0.058 10 124922211 _T3 BUB3 74.03 56.06 0.412 11 429488 _T3 ANO9 373.59 22.82 1 11 1255051 _T3 MUC5B 107.56 386.77 0.277 11 1268355 _T3 MUC5B 11.64 386.77 0.109 11 17118740 _T3 PIK3C2A 18.89 13.23 0.362 11 30352754 _T3 ARL14EP 30.92 10.13 0.389 11 57569589 _T3 CTNND1 9.8 35.88 0.183 11 64537812 _T3 SF1 243.09 43.26 0.355 11 64863791 _T3 VPS51 6.5 19.63 0.682 11 64875769 _T3 VPS51 25.36 19.63 0.42 11 64897243 _T3 SYVN1 127.13 18.99 0.107 11 65299094 _T3 SCYL1 254.72 15.5 0.346 11 66276808 _T3 DPP3 215.59 24.91 0.423 11 67196682 _T3 RPS6KB2 101.45 24.44 0.082 11 77412076 _T3 RSF1 18.57 26.77 0.469 11 85438195 _T3 SYTL2 262.35 16.46 0.136 11 93428779 _T3 KIAA1731 9.08 18.18 0.127

11 104878041 _T3 CASP5 20.03 16.23 1 11 117057325 _T3 SIDT2 83.28 17.94 0.266 11 126137948 _T3 SRPR 120.15 28.06 0.105 11 128840184 _T3 ARHGAP32 222.87 35.39 0.151 12 7047705 _T3 ATN1 12.71 21.41 0.455 12 11992182 _T3 ETV6 79.18 11.38 0.364 12 46125019 _T3 ARID2 317.81 15.75 0.375 12 48533655 _T3 PFKM 26.83 20.13 0.37 12 57492342 _T3 STAT6 305.65 33.06 0.279 12 57648750 _T3 R3HDM2 21.99 20.64 0.444 12 58142979 _T3 CDK4 160.24 96.77 0.403 12 67699482 _T3 CAND1 10.52 14.41 0.211 12 108145300 _T3 PRDM4 23.51 14.35 0.421 13 33091955 _T3 N4BP2L2 91.78 30.74 0.129 13 34395375 _T3 RFC3 317.75 14.82 0.37 13 38138663 _T3 POSTN 47.67 70.92 0.085 13 51517523 _T3 RNASEH2B 28.86 27.58 0.098 13 60385030 _T3 DIAPH3 153.7 19.48 0.31 13 73357634 _T3 PIBF1 11.41 25.57 0.416 13 77780907 _T3 MYCBP2 20.69 20.11 0.366 13 103298739 _T3 TPP2 49.91 26.6 0.519 13 103309437 _T3 TPP2 28.68 26.6 0.333 13 111935522 _T3 ARHGEF7 236.68 18.12 0.369 13 115064415 _T3 UPF3A 399.44 23.6 0.235 14 23393255 _T3 PRMT5 86.71 31.1 0.471 14 23531665 _T3 ACIN1 109.05 125.87 0.364 14 23549379 _T3 ACIN1 47.38 125.87 0.295 14 24033048 _T3 AP1G2 102.67 23.91 0.464 14 24644781 _T3 REC8 30.81 16.38 0.053 14 35872925 _T3 NFKBIA 110.71 89.98 0.118 14 50606707 _T3 SOS2 25.79 16.07 0.316

14 55647931 _T3 DLGAP5 367.57 18.49 0.094 14 69521773 _T3 DCAF5 128.56 10.47 0.442 14 75248388 _T3 YLPM1 52.85 22.98 0.417 14 75278342 _T3 YLPM1 146.48 22.98 0.09 14 76639909 _T3 GPATCH2L 13.73 19.51 0.294 14 78036776 _T3 SPTLC2 9.66 15.49 0.435 14 91947951 _T3 SMEK1 379.53 17.23 0.318 14 92472032 _T3 TRIP11 175.21 22.78 0.061 14 99961885 _T3 CCNK 14.99 18.88 0.211 14 100826907 _T3 WARS 56.74 53.72 0.074 14 102445788 _T3 DYNC1H1 8.12 122.21 0.122 15 28501429 _T3 HERC2 46.82 43.74 0.073 15 31229400 _T3 FAN1 65.86 10.86 0.375 15 40226481 _T3 EIF2AK4 156.27 20.28 0.465 15 42054541 _T3 MGA 8.97 23.17 0.342 15 51755618 _T3 DMXL2 15.6 11.16 0.176 15 52503953 _T3 MYO5C 159.6 35.12 0.061 15 64686218 _T3 TRIP4 204.72 25.51 0.127 15 70976680 _T3 UACA 391.88 17.33 0.071 15 93527672 _T3 CHD2 211.05 265.31 0.485 16 15758700 _T3 NDE1 76.37 29.99 0.45 16 28157446 _T3 XPO6 51.33 27.93 0.295 16 30435660 _T3 DCTPP1 172.1 20.2 0.086 16 46695735 _T3 VPS35 23.82 27.63 0.059 16 57503884 _T3 POLR2C 31.21 20.56 0.419 16 57786443 _T3 KATNB1 39.54 17.96 0.304 16 58585148 _T3 CNOT1 175.67 73.6 0.352 16 58756055 _T3 GOT2 97.39 13.49 0.488 16 70590109 _T3 SF3B3 203.61 28.62 0.434 16 74976691 _T3 WDR59 21.7 20.56 0.444 16 88798170 _T3 PIEZO1 258.65 37.29 0.139

16 89718047 _T3 CHMP1A 63.3 10.31 0.269 17 1373747 _T3 MYO1C 9.71 57.35 0.126 17 1581895 _T3 PRPF8 9.03 103.76 0.064 17 1586913 _T3 PRPF8 268.97 103.76 0.413 17 7402719 _T3 POLR2A 47.56 64.33 0.211 17 7804292 _T3 CHD3 30.41 40.73 0.282 17 20108296 _T3 SPECC1 30.07 24.45 0.314 17 27445433 _T3 MYO18A 81.94 23 0.379 17 33319589 _T3 LIG3 127.13 12.98 0.542 17 34036252 _T3 AP2B1 14.55 29.3 0.135 17 37682329 _T3 CDK12 125.71 23.57 0.428 17 38179525 _T3 MED24 9.71 13.71 0.261 17 40932962 _T3 WNK4 38.87 15.82 0.421 17 40936532 _T3 WNK4 264.29 15.82 0.474 17 41603872 _T3 DHX8 30.13 23.92 0.625 17 44249467 _T3 KANSL1 21.54 20.12 0.342 17 48460506 _T3 LRRC59 195.42 51.39 0.353 17 49067998 _T3 SPAG9 259.97 21.9 0.286 17 58262903 _T3 USP32 214.19 10.02 0.379 17 62559011 _T3 SMURF2 82.44 14.83 0.275 17 73518109 _T3 TSEN54 106.81 19.26 0.486 17 73566225 _T3 LLGL2 119.91 65.16 0.493 17 76799557 _T3 USP36 292.34 12.27 0.347 17 80049503 _T3 FASN 118.55 40.73 0.508 17 80195589 _T3 SLC16A3 30.57 17.32 0.195 18 18625344 _T3 ROCK1 232.31 23.44 0.063 18 39647473 _T3 PIK3C3 72.31 30.23 0.286 18 45374927 _T3 SMAD2 349.85 21.36 0.075 18 61060776 _T3 VPS4B 21.18 15.58 0.303 19 799415 _T3 PTBP1 95.95 47.86 0.093 19 1429980 _T3 DAZAP1 73.93 33.5 0.457

19 2132523 _T3 AP3D1 27.29 33.66 0.405 19 3982421 _T3 EEF2 57.59 276.46 0.355 19 5600224 _T3 SAFB2 25.44 52.02 0.098 19 7593075 _T3 MCOLN1 54.19 10.93 0.5 19 7687493 _T3 XAB2 333 12.26 0.319 19 8008521 _T3 TIMM44 142.75 24.09 0.167 19 8609230 _T3 MYO1F 80.68 16.7 0.121 19 10940882 _T3 DNM2 456.42 211.98 0.177 19 11098558 _T3 SMARCA4 63.74 89.28 0.306 19 11326559 _T3 DOCK6 30.3 12.67 0.172 19 11618364 _T3 ECSIT 229.12 11.85 0.348 19 12812612 _T3 TNPO2 91.33 11.33 0.416 19 18976409 _T3 UPF1 90.77 19.11 0.426 19 19039063 _T3 DDX49 249.54 47.87 0.231 19 38572578 _T3 SIPA1L3 4.6 10.94 0.467 19 40377134 _T3 FCGBP 105.49 1165.32 0.091 19 42409122 _T3 ARHGEF1 8.25 40.14 0.25 19 42410689 _T3 ARHGEF1 113.09 40.14 0.208 19 46025991 _T3 VASP 212.48 50.69 0.064 19 46278235 _T3 DMPK 84.36 13.1 0.15 19 46334766 _T3 SYMPK 22.55 32.81 0.452 19 49674847 _T3 TRPM4 233.98 34.3 0.366 19 49685917 _T3 TRPM4 17.61 34.3 0.27 19 49699776 _T3 TRPM4 5.61 34.3 0.5 19 54669235 _T3 TMC4 168.56 11.65 0.467 19 58772964 _T3 ZNF544 32.31 17.23 0.375 2 32706407 _T3 BIRC6 5.16 39.37 0.235 2 33813525 _T3 FAM98A 26.14 12.76 0.182 2 44128579 _T3 LRPPRC 89.56 58.23 0.311 2 44145403 _T3 LRPPRC 365.52 58.23 0.376 2 46574154 _T3 EPAS1 7.72 21.65 0.12

2 54133991 _T3 PSME4 15.12 22.45 0.166 2 98611950 _T3 TMEM131 29.5 14.22 0.607 2 109087914 _T3 GCC2 29.12 41.24 0.315 2 152320541 _T3 RIF1 37.03 23.49 0.348 2 157369871 _T3 GPD2 94.49 14.1 0.326 2 159517885 _T3 PKP4 142.73 23.19 0.132 2 169716102 _T3 NOSTRIN 165.66 28.01 0.108 2 170460581 _T3 PPIG 13.64 47.05 0.365 2 174062782 _T3 ZAK 181.25 16.85 0.384 2 178077589 _T3 HNRNPA3 97.63 109.13 0.255 2 183829479 _T3 NCKAP1 181.02 31.75 0.183 2 209215633 _T3 PIKFYVE 19.09 19.58 0.373 2 216199708 _T3 ATIC 254.29 76.43 0.427 2 233194613 _T3 DIS3L2 15.19 33.46 0.174 2 242431044 _T3 FARP2 127.35 24.03 0.514 20 2635515 _T3 NOP56 67.49 89.52 0.064 20 2819288 _T3 PCED1A 216.29 16.99 0.051 20 3891287 _T3 PANK2 394.34 28.14 0.39 20 16486373 _T3 KIF16B 37.78 17.61 0.542 20 23334911 _T3 NXT1 261.58 13 0.341 20 44520930 _T3 CTSA 321.2 73.52 0.211 20 45875072 _T3 ZMYND8 105.88 22.66 0.114 20 47858504 _T3 DDX27 298.5 24.31 0.135 20 49196293 _T3 PTPN1 7.53 11.4 0.162 20 56139237 _T3 PCK1 109.57 14.43 0.548 20 61542747 _T3 DIDO1 10.49 39.42 0.5 21 34619186 _T3 IFNAR2 133.22 13.42 0.103 21 34660554 _T3 IL10RB 117.82 21.55 0.324 21 38525560 _T3 TTC3 270.13 42.4 0.229 21 42807869 _T3 MX1 32.47 19.85 0.341 21 47662805 _T3 MCM3AP 26.7 25.06 0.179

21 47845883 _T3 PCNT 229.28 40.66 0.087 22 19381935 _T3 HIRA 42.67 16.13 0.876 22 22160309 _T3 MAPK1 23.25 17.22 0.657 22 32211085 _T3 DEPDC5 226.1 23.77 0.08 22 39125567 _T3 GTPBP1 24.59 11.87 0.163 22 39138313 _T3 SUN2 130.65 10.51 0.5 22 42032631 _T3 XRCC6 147.55 143.05 0.873 22 44392231 _T3 SAMM50 70.73 17.54 0.5 3 10312029 _T3 TATDN2 321.7 13.84 0.288 3 25657052 _T3 TOP2B 285.72 41.4 0.102 3 33648152 _T3 CLASP2 12.26 14.41 0.407 3 36897975 _T3 TRANK1 39.98 10.24 0.333 3 37107426 _T3 LRRFIP2 299.11 21.73 0.463 3 41266137 _T3 CTNNB1 18.36 209.94 0.752 3 44879832 _T3 KIF15 15.68 10.32 0.4 3 45153647 _T3 CDCP1 146.65 21.17 0.469 3 47045314 _T3 NBEAL2 202.29 45.77 0.407 3 47165283 _T3 SETD2 9.68 41.9 0.152 3 48459616 _T3 PLXNB1 42.31 15.81 0.458 3 48664386 _T3 SLC26A6 148.5 35.08 0.413 3 51671237 _T3 RAD54L2 96.07 15 0.333 3 51718549 _T3 TEX264 90.07 11.08 0.452 3 52682395 _T3 PBRM1 253.37 17.25 0.106 3 58062841 _T3 FLNB 48.62 56.12 0.491 3 63981203 _T3 ATXN7 80.77 19.75 0.063 3 69126954 _T3 UBA3 109.64 15.84 0.063 3 122880782 _T3 PDIA5 383.07 36.12 0.125 3 127788492 _T3 SEC61A1 382.22 52.46 0.418 3 128339333 _T3 RPN1 246.79 127.5 0.051 3 134251733 _T3 CEP63 50.95 17.67 0.221 3 155301374 _T3 PLCH1 357.61 11.48 0.417

3 184033630 _T3 EIF4G1 139.58 160.32 0.56 3 184714222 _T3 VPS8 83.5 21.14 0.393 4 3201572 _T3 HTT 29.58 20.81 0.351 4 40439875 _T3 RBM47 12 12.15 0.224 4 48604083 _T3 FRYL 189.71 60.73 0.163 4 48852045 _T3 OCIAD1 36.89 17.83 0.259 4 83785565 _T3 SEC31A 10.34 28.36 0.104 4 113566025 _T3 LARP7 72.66 21.69 0.567 4 123097025 _T3 KIAA1109 274.7 27.32 0.29 4 146059717 _T3 OTUD4 8.47 13.01 0.528 4 166231859 _T3 KLHL2 13.61 15.63 0.224 4 185340664 _T3 IRF2 66.35 14.1 0.544 5 889726 _T3 BRD9 18.97 44.22 0.052 5 908485 _T3 TRIP13 40.23 16.52 0.203 5 5463351 _T3 KIAA0947 9.47 16.55 0.494 5 14297299 _T3 TRIO 64.51 67.46 0.072 5 32404161 _T3 ZFR 16.48 18.13 0.211 5 36153056 _T3 SKP2 11.42 34.03 0.163 5 74651022 _T3 HMGCR 8.02 10.42 0.222 5 86672317 _T3 RASA1 113.98 21.95 0.5 5 96322302 _T3 LNPEP 293.84 18.91 0.174 5 102295655 _T3 PAM 31.22 14.57 0.339 5 102493987 _T3 PPIP5K2 136.21 15.96 0.489 5 130498366 _T3 HINT1 71.23 173.15 0.377 5 130778140 _T3 RAPGEF6 134.22 27.45 0.235 5 130808408 _T3 RAPGEF6 66.63 27.45 0.411 5 157214668 _T3 CLINT1 476.47 39.64 0.057 5 175995721 _T3 CDHR2 26.27 16.75 0.163 5 180668595 _T3 GNB2L1 128.1 430.97 0.37 6 31604005 _T3 PRRC2A 239.08 35.14 0.191 6 33177896 _T3 RING1 17.57 10.86 0.2

6 33273073 _T3 TAPBP 11.12 35.16 0.212 6 33384467 _T3 CUTA 98.96 30.71 0.07 6 41552550 _T3 FOXP4 126.9 11 0.276 6 88313235 _T3 ORC3 213.8 12.48 0.31 6 90432675 _T3 MDN1 150.14 20.22 0.444 6 128312479 _T3 PTPRK 253.68 23.48 0.552 6 128561239 _T3 PTPRK 203.33 23.48 0.333 6 131924228 _T3 MED23 14.1 16.61 0.297 6 151281537 _T3 MTHFD1L 38.08 34.45 0.417 7 1513920 _T3 INTS1 178.82 18.01 0.222 7 6085736 _T3 EIF2AK1 20.62 31.76 0.405 7 27187076 _T3 HOXA6 15.82 13.62 0.357 7 44664075 _T3 OGDH 50.5 41.52 0.231 7 65439343 _T3 GUSB 80.19 45.94 0.287 7 76134854 _T3 DTX2 43.58 31.88 0.488 7 91730195 _T3 AKAP9 28.7 71.16 0.412 7 91957188 _T3 ANKIB1 54.59 17.07 0.295 7 95750624 _T3 SLC25A13 17.47 16.68 0.333 7 97939854 _T3 BAIAP2L1 19.65 22.74 0.333 7 99693064 _T3 MCM7 43.93 94.07 0.486 7 99869587 _T3 GATS 359.06 14.76 0.516 7 100867051 _T3 ZNHIT1 8.68 21.02 0.466 7 106924081 _T3 COG5 4.65 35.19 0.426 7 132659981 _T3 CHCHD3 327.72 46.97 0.469 7 139829301 _T3 JHDM1D 303.34 16.49 0.443 7 140482927 _T3 BRAF 40.4 22.15 0.327 7 143078672 _T3 ZYX 7.53 25.8 0.321 8 23148931 _T3 R3HCC1 41.2 35.3 0.216 8 37553561 _T3 ZNF703 18.28 12.47 0.56 8 55060097 _T3 MRPL15 199.36 11.81 0.227 8 62475367 _T3 ASPH 221.69 44.96 0.323 8 68163617 _T3 ARFGEF1 67.77 22.72 0.072

8 120220743 _T3 MAL2 22.59 15.98 0.579 8 124384893 _T3 ATAD2 8.63 36.35 0.158 8 144943007 _T3 EPPK1 247.39 37.51 0.525 9 5742971 _T3 KIAA1432 80.29 15.78 0.117 9 35801960 _T3 NPR2 56.65 11.2 0.412 9 95947849 _T3 WNK2 180.87 58.95 0.516 9 99113417 _T3 SLC35D2 12.82 10.42 0.326 9 130929153 _T3 CIZ1 61.3 27.39 0.31 9 131222859 _T3 ODF2 27.45 57.23 0.386 9 132581100 _T3 TOR1A 105.92 14.86 0.457 9 140075271 _T3 ANAPC2 31.98 13.92 0.409 X 10535266 _T3 MID1 436.67 35.53 0.52 X 47072566 _T3 UBA1 47.23 191.54 0.496 X 53627138 _T3 HUWE1 17.6 54.43 0.051 X 57405179 _T3 FAAH2 92.59 15.19 1 X 69719838 _T3 DLG3 165.6 24.8 0.319 X 152960039 _T3 SLC6A8 246.7 14.72 0.127 Predicted neoantigens with binding affinity <500nM, allele frequency>5% and mrna expression>10 transcripts per million (TPM).

etable 10. Pathways analysis of MHC I and II neoantigens Ingenuity Canonical Group -log(p-value) Ratio Genes MHC Pathways Transcriptional Regulatory FAP 2.76E+00 1.25E-01 SET,TRIM24,RIF1,SKIL,STAT3 MHC_I Network in Embryonic Stem Cells Transcriptional Regulatory Hyper 2.68E-01 2.50E-02 KAT6A MHC_I Network in Embryonic Stem Cells Transcriptional Regulatory Tumor 3.48E-01 2.50E-02 RIF1 MHC_I Network in Embryonic Stem Cells Estrogen Receptor FAP 2.14 0.0625 MED13,CDK8,MED20,SPEN,TBP,NCOR1,GTF2F1, MED13L MHC_I Estrogen Receptor 0.24 0.00781 MED23 MHC_I Estrogen Receptor Hyper 0.351 0.0234 MAPK1,TRRAP,MED14 MHC_I Estrogen Receptor Tumor 3.91 0.0703 TAF1,MED23,POLR2A,ERCC3,TRRAP,NCOR1,PC K1,MED24,SMARCA4 MHC_I DNA damage-induced 14-3- FAP 2.11 0.158 RAD17,CCNB2,ATR MHC_I 3σ DNA damage-induced 14-3- Tumor 0.608 0.0526 AKT2 MHC_I 3σ trna Charging FAP 2.03 0.105 WARS2,EARS2,IARS,FARSB MHC_I trna Charging 0.649 0.0263 VARS MHC_I trna Charging Hyper 1.45 0.0789 YARS,VARS2,IARS MHC_I trna Charging Tumor 1.73 0.0789 WARS,RARS,EPRS MHC_I

Protein Ubiquitination Pathway FAP 1.97 0.0472 USP21,UBE2A,UBE2Q1,MED20,USP15,HSPH1,UB E3B,USP54,USP30,USP33,USP34,UBE3A MHC_I Protein Ubiquitination Pathway Protein Ubiquitination Pathway 1.56 0.0197 PSMD10,USP5,UCHL5,AMFR,SKP2 MHC_I Tumor 1.77 0.0341 ANAPC2,USP7,USP15,USP5,PSMD12,BIRC6,ANA MHC_I PC5,UBA1,SKP2 D-myo-inositol-5-phosphate Metabolism FAP 1.67 0.0516 PPFIA1,SET,PLCB4,PTPRH,DUSP11,PPP4R1,PPP 3CA,SACM1L MHC_I D-myo-inositol-5-phosphate Metabolism D-myo-inositol-5-phosphate Metabolism D-myo-inositol-5-phosphate Metabolism Cell Cycle: G2/M DNA Damage Checkpoint Regulation Cell Cycle: G2/M DNA Damage Checkpoint Regulation Cell Cycle: G2/M DNA Damage Checkpoint Regulation Cell Cycle: G2/M DNA Damage Checkpoint Regulation 1.07 0.0194 PLCD3,PTPRH,DUSP16 MHC_I Hyper 0.242 0.0194 MTMR6,SGPP2,PPM1F MHC_I Tumor 0.395 0.0194 PTPN1,RASA1,PTEN MHC_I FAP 1.65 0.0816 TOP2B,TRIP12,CCNB2,ATR MHC_I Hyper 0.554 0.0204 SKP2 MHC_I 0.213 0.0204 TRIP12 MHC_I Tumor 0.787 0.0408 TOP2B,SKP2 MHC_I ATM FAP 1.53 0.0633 HERC2,RAD17,CCNB2,ATR,NBN MHC_I ATM 0.386 0.0127 TOPBP1 MHC_I

ATM Hyper 1.19 0.0506 FANCD2,TRRAP,TLK2,NBN MHC_I ATM Tumor 2.2 0.0633 HERC2,USP7,JUN,TOPBP1,TRRAP MHC_I Wnt/β-catenin FAP 1.52 0.0482 AXIN2,APPL2,CSNK1A1,TLE1,BMPR2,SOX9,TCF7 L2,LRP1 MHC_I Wnt/β-catenin Hyper 0.67 0.0301 TGFBR1,CSNK1G2,MARK2,DVL3,LRP1 MHC_I Wnt/β-catenin Tumor 0.974 0.0296 AKT2,JUN,HDAC1,ILK,CTNNB1 MHC_I D-myo-inositol (1,4,5,6)- Tetrakisphosphate Biosynthesis D-myo-inositol (1,4,5,6)- Tetrakisphosphate Biosynthesis D-myo-inositol (1,4,5,6)- Tetrakisphosphate Biosynthesis D-myo-inositol (1,4,5,6)- Tetrakisphosphate Biosynthesis D-myo-inositol (3,4,5,6)- tetrakisphosphate Biosynthesis D-myo-inositol (3,4,5,6)- tetrakisphosphate Biosynthesis D-myo-inositol (3,4,5,6)- tetrakisphosphate Biosynthesis D-myo-inositol (3,4,5,6)- tetrakisphosphate Biosynthesis FAP 1.5 0.0511 PPFIA1,SET,PTPRH,DUSP11,PPP4R1,PPP3CA,SA CM1L Hyper MHC_I 0.635 0.0146 PTPRH,DUSP16 MHC_I 0.31 0.0219 MTMR6,SGPP2,PPM1F MHC_I Tumor 0.481 0.0219 PTPN1,RASA1,PTEN MHC_I FAP 1.5 0.0511 PPFIA1,SET,PTPRH,DUSP11,PPP4R1,PPP3CA,SA CM1L Hyper MHC_I 0.635 0.0146 PTPRH,DUSP16 MHC_I 0.31 0.0219 MTMR6,SGPP2,PPM1F MHC_I Tumor 0.481 0.0219 PTPN1,RASA1,PTEN MHC_I Isoleucine Degradation I FAP 1.44 0.143 ACAT2,EHHADH MHC_I Telomere Extension by FAP 1.38 0.133 TERF2IP,NBN MHC_I Telomerase

Telomere Extension by Hyper 0.599 0.0667 NBN MHC_I Telomerase Telomere Extension by Tumor 0.698 0.0667 XRCC6 MHC_I Telomerase Glutaryl-CoA Degradation FAP 1.38 0.133 ACAT2,EHHADH MHC_I RhoA FAP 1.31 0.05 ROCK2,ACTR2,BAIAP2,ARHGAP12,MYLK,ARHGA P1 MHC_I RhoA RhoA 3-phosphoinositide Degradation 3-phosphoinositide Degradation 3-phosphoinositide Degradation 3-phosphoinositide Degradation Cell Cycle Control of Chromosomal Replication Cell Cycle Control of Chromosomal Replication Cell Cycle Control of Chromosomal Replication Role of BRCA1 in DNA Damage Response Role of BRCA1 in DNA Damage Response Role of BRCA1 in DNA Damage Response 0.72 0.0167 ARHGEF1,PLD1 MHC_I Hyper 1.09 0.0417 PTK2,ARHGAP5,BAIAP2,PI4KA,PKN1 MHC_I FAP 1.31 0.0464 PPFIA1,SET,PTPRH,DUSP11,PPP4R1,PPP3CA,SA MHC_I CM1L 1.1 0.0199 PTPRH,MTM1,DUSP16 MHC_I Hyper 0.256 0.0199 MTMR6,SGPP2,PPM1F MHC_I Tumor 0.413 0.0199 PTPN1,RASA1,PTEN MHC_I FAP 1.3 0.0789 TOP2B,PRIM1,ORC4 MHC_I 0.649 0.0263 MCM4 MHC_I Tumor 2.55 0.1 TOP2B,ORC3,POLE,MCM4 MHC_I FAP 1.03 0.0513 ABRAXAS1,ATR,SMARCD1,NBN MHC_I Hyper 1.82 0.0385 PBRM1,TOPBP1,SMARCD1 MHC_I 1.77 0.0641 E2F4,FANCD2,SMARCB1,HLTF,NBN MHC_I

Role of BRCA1 in DNA Damage Response Tumor 2.98 0.0769 PBRM1,SMARCA2,TOPBP1,MSH6,SMARCA4,MLH 1 MHC_I autophagy FAP 0.976 0.0577 ATG5,CTSA,VPS41 MHC_I autophagy 0.532 0.0192 ATG9A MHC_I autophagy Hyper 0.581 0.0385 VPS33A,CTSF MHC_I autophagy Tumor 1.34 0.0556 CTSA,MTOR,PIK3C3 MHC_I Leptin in Obesity FAP 0.946 0.0476 PLCB4,PDIA3,PDE3B,STAT3 MHC_I Leptin in Obesity 0.967 0.0238 PLCD3,FGFR2 MHC_I Leptin in Obesity Hyper 1.11 0.0476 MAPK1,ADCY3,ADCY6,PIK3R2 MHC_I Leptin in Obesity Tumor 1.43 0.0471 AKT2,PIK3C2A,PIK3C3,PIK3R1 MHC_I NF-κB Activation by Viruses FAP 0.919 0.0465 TBP,ITGA1,EIF2AK2,PRKD3 MHC_I NF-κB Activation by Viruses 0.359 0.0116 FGFR2 MHC_I NF-κB Activation by Viruses Hyper 0.643 0.0349 MAPK1,PRKCH,PIK3R2 MHC_I NF-κB Activation by Viruses Tumor 1.4 0.046 AKT2,PIK3C2A,PIK3C3,PIK3R1 MHC_I Protein Kinase A FAP 0.899 0.0319 ROCK2,PLCB4,PTPRH,ADD3,PDIA3,PDE3B,DUSP 11,MYLK,PYGL,PRKD3,PPP3CA,TCF7L2 MHC_I Protein Kinase A 0.616 0.0106 PLCD3,PTPRH,PTPRR,DUSP16 MHC_I

Protein Kinase A Hyper 0.729 0.0266 PTK2,TGFBR1,MAPK1,ITPR2,ADCY3,ADCY6,PRK CH,PTPN3,NFATC4,PTPN21 MHC_I Protein Kinase A Tumor 1.58 0.0289 BRAF,ANAPC2,FLNB,PHKB,PTPRK,PTPN1,ITPR3, ANAPC5,PYGB,CTNNB1,PTEN MHC_I Gap Junction FAP 0.799 0.0361 PLCB4,PDIA3,TJP1,CSNK1A1,PRKD3,PPP3CA MHC_I Gap Junction Gap Junction Hyper 0.518 0.012 PLCD3,FGFR2 MHC_I 1.39 0.0422 MAPK1,CSNK1G2,ITPR2,ADCY3,ADCY6,PRKCH,P IK3R2 MHC_I Gap Junction Tumor 2.46 0.0479 AKT2,PIK3C2A,TUBB4B,PIK3C3,PIK3R1,ITPR3,CT NNB1,NPR2 MHC_I Pyridoxal 5'-phosphate Salvage Pathway Pyridoxal 5'-phosphate Salvage Pathway Pyridoxal 5'-phosphate Salvage Pathway FAP 0.781 0.0469 CDK8,CSNK1A1,EIF2AK2 MHC_I Hyper 2.12 0.0781 PRKX,DMPK,MAPK1,PRKCH,PKN1 MHC_I Tumor 1.16 0.0469 BRAF,AKT2,DMPK MHC_I TR/RXR Activation FAP 0.773 0.0408 PDE3B,NCOA6,NCOR1,THRA MHC_I TR/RXR Activation 0.318 0.0102 FGFR2 MHC_I TR/RXR Activation Tumor 4.83 0.0918 SLC16A3,AKT2,MTOR,PIK3C2A,PIK3C3,PIK3R1,F ASN,NCOR1,PCK1 MHC_I

Mouse Embryonic Stem Cell Pluripotency Mouse Embryonic Stem Cell Pluripotency Mouse Embryonic Stem Cell Pluripotency Mouse Embryonic Stem Cell Pluripotency Epithelial Adherens Junction Epithelial Adherens Junction FAP 0.7 0.0381 IL6ST,BMPR2,STAT3,TCF7L2 MHC_I 0.297 0.00952 FGFR2 MHC_I Hyper 0.486 0.0286 MAPK1,DVL3,PIK3R2 MHC_I Tumor 1.7 0.0476 AKT2,PIK3C2A,PIK3C3,PIK3R1,CTNNB1 MHC_I FAP 0.686 0.035 ACTR2,BAIAP2,BMPR2,TCF7L2,CLIP1 MHC_I Hyper 1.69 0.049 RAPGEF1,MYH9,TGFBR1,NECTIN3,BAIAP2,ACTN 1,NECTIN2 MHC_I Epithelial Adherens Junction Tumor 2.88 0.0559 AKT2,TUBB4B,NECTIN3,ZYX,CLINT1,CTNNB1,CT NND1,PTEN MHC_I Stearate Biosynthesis I (Animals) Stearate Biosynthesis I (Animals) FAP 0.66 0.05 ZADH2,ELOVL1 MHC_I 0.629 0.025 LPCAT4 MHC_I Hyper 0.749 0.05 SRD5A3,THEM4 MHC_I Tumor 1.68 0.075 ACSL3,FASN,ACOT9 MHC_I Stearate Biosynthesis I (Animals) Stearate Biosynthesis I (Animals) RAR Activation FAP 0.641 0.0321 TRIM24,RDH14,NCOR1,SMARCD1,RDH13,PRKD3 MHC_I RAR Activation RAR Activation Hyper 0.889 0.016 PBRM1,STAT5A,SMARCD1 MHC_I 1.99 0.0481 STAT5A,MAPK1,SMARCB1,ADCY3,ADCY6,PRKCH,PIK3R2,HLTF,PSMC5 MHC_I RAR Activation Tumor 2.72 0.0481 PBRM1,AKT2,JUN,SMARCA2,ERCC3,PIK3R1,NCO MHC_I

R1,SMARCA4,PTEN Cleavage and Polyadenylation of Pre-mRNA Cleavage and Polyadenylation of Pre-mRNA Cleavage and Polyadenylation of Pre-mRNA Role of NFAT in Cardiac Hypertrophy FAP 0.631 0.0833 CSTF1 MHC_I 1.11 0.0833 CPSF2 MHC_I Hyper 0.684 0.0833 CPSF1 MHC_I FAP 0.627 0.0317 IL6ST,PLCB4,PDIA3,CSNK1A1,PRKD3,PPP3CA MHC_I Role of NFAT in Cardiac Hypertrophy Role of NFAT in Cardiac Hypertrophy Hyper 0.445 0.0106 PLCD3,FGFR2 MHC_I 2.44 0.0529 TGFBR1,CAMK1,MAPK1,HDAC8,ITPR2,ADCY3,AD CY6,PRKCH,PIK3R2,NFATC4 MHC_I Role of NFAT in Cardiac Hypertrophy Tumor 1.63 0.0368 AKT2,PIK3C2A,PIK3C3,PIK3R1,HDAC1,ITPR3,CAB IN1 MHC_I Cholesterol Biosynthesis I FAP 0.601 0.0769 DHCR7 MHC_I Cholesterol Biosynthesis I Tumor 1.82 0.154 HSD17B7,LBR MHC_I Cholesterol Biosynthesis II FAP 0.601 0.0769 DHCR7 MHC_I (via 24,25-dihydrolanosterol) Cholesterol Biosynthesis II Tumor 1.82 0.154 HSD17B7,LBR MHC_I (via 24,25-dihydrolanosterol) Cholesterol Biosynthesis III FAP 0.601 0.0769 DHCR7 MHC_I (via Desmosterol) Cholesterol Biosynthesis III Tumor 1.82 0.154 HSD17B7,LBR MHC_I (via Desmosterol) Gαq FAP 0.574 0.0316 ROCK2,BTK,PLCB4,PRKD3,PPP3CA MHC_I Gαq 0.547 0.0127 FGFR2,PLD1 MHC_I

Gαq Hyper 0.729 0.0316 MAPK1,ITPR2,PRKCH,PIK3R2,NFATC4 MHC_I Gαq Tumor 1.51 0.0377 AKT2,PLD3,PIK3C2A,PIK3C3,PIK3R1,ITPR3 MHC_I Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency FAP 0.569 0.0333 IL6ST,RIF1,BMPR2,STAT3 MHC_I 0.258 0.00833 FGFR2 MHC_I Tumor 2.05 0.05 AKT2,RIF1,PIK3C2A,PIK3C3,PIK3R1,CTNNB1 MHC_I IL-3 FAP 0.562 0.0361 STAT3,PRKD3,PPP3CA MHC_I IL-3 0.975 0.0241 STAT5A,FGFR2 MHC_I IL-3 Hyper 1.67 0.0602 RAPGEF1,STAT5A,MAPK1,PRKCH,PIK3R2 MHC_I IL-3 Tumor 2.11 0.0602 AKT2,JUN,PIK3C2A,PIK3C3,PIK3R1 MHC_I Thrombin FAP 0.559 0.03 ROCK2,PLCB4,PDIA3,TBP,MYLK,PRKD3 MHC_I Thrombin Thrombin Hyper 0.827 0.015 PLCD3,FGFR2,ARHGEF1 MHC_I 1.41 0.04 PTK2,CAMK1,MAPK1,ITPR2,ADCY3,ADCY6,PRKC H,PIK3R2 MHC_I Thrombin Tumor 1.1 0.0299 AKT2,PIK3C2A,PIK3C3,PIK3R1,ITPR3,ARHGEF1 MHC_I PI3K in B Lymphocytes PI3K in B Lymphocytes FAP 0.538 0.0323 BTK,PLCB4,PDIA3,PPP3CA MHC_I 0.248 0.00806 PLCD3 MHC_I

PI3K in B Lymphocytes PI3K in B Lymphocytes Assembly of RNA Polymerase II Complex Assembly of RNA Polymerase II Complex Hyper 0.669 0.0323 MAPK1,ITPR2,PIK3R2,NFATC4 MHC_I Tumor 1.41 0.0397 AKT2,JUN,PIK3R1,ITPR3,PTEN MHC_I FAP 0.522 0.04 TBP,GTF2F1 MHC_I Tumor 1.42 0.06 TAF1,POLR2A,ERCC3 MHC_I PPARα/RXRα Activation FAP 0.522 0.0301 PLCB4,PDIA3,NCOA6,BMPR2,NCOR1 MHC_I PPARα/RXRα Activation 1 0.0181 PLCD3,MED23,CPT1B MHC_I PPARα/RXRα Activation Hyper 0.405 0.0241 TGFBR1,MAPK1,ADCY3,ADCY6 MHC_I PPARα/RXRα Activation Tumor 2.44 0.0476 CAND1,MED23,JUN,GPD2,FASN,NCOR1,MED24,A DIPOR1 MHC_I Acute Myeloid Leukemia Acute Myeloid Leukemia Acute Myeloid Leukemia Acute Myeloid Leukemia FAP 0.5 0.0333 STAT3,SPI1,TCF7L2 MHC_I 0.917 0.0222 STAT5A,FGFR2 MHC_I Hyper 0.605 0.0333 STAT5A,MAPK1,PIK3R2 MHC_I Tumor 2.61 0.0652 BRAF,AKT2,MTOR,PIK3C2A,PIK3C3,PIK3R1 MHC_I p70s6k FAP 0.496 0.0308 BTK,PLCB4,PDIA3,PRKD3 MHC_I p70s6k 1.25 0.0231 PLCD3,FGFR2,PLD1 MHC_I p70s6k Hyper 0.622 0.0308 MAPK1,PRKCH,PIK3R2,BCAP31 MHC_I p70s6k Tumor 1.88 0.0458 AKT2,MTOR,PIK3C2A,EEF2,PIK3C3,PIK3R1 MHC_I

EIF2 FAP 0.492 0.0283 PTBP1,EIF5B,EIF4G3,EIF2AK2,RPS17,EIF2AK3 MHC_I EIF2 Tumor 1.41 0.033 EIF2AK4,AKT2,WARS,PIK3C2A,PIK3C3,PIK3R1,EI F5B MHC_I Phagosome Maturation FAP 0.47 0.0299 DYNC1H1,CTSA,VPS41,ATP6V0D1 MHC_I Phagosome Maturation 0.649 0.0149 ATP6V0A2,ATP6V0D1 MHC_I Phagosome Maturation Hyper 0.593 0.0299 CALR,VPS33A,NAPA,CTSF MHC_I Phagosome Maturation Tumor 1.77 0.0435 DYNC1H1,CTSA,TUBB4B,PIK3C3,ATP6V0D1,ATP6 V0A1 MHC_I Salvage Pathways of Pyrimidine Ribonucleotides Salvage Pathways of Pyrimidine Ribonucleotides Salvage Pathways of Pyrimidine Ribonucleotides DNA Methylation and Transcriptional Repression DNA Methylation and Transcriptional Repression FAP 0.468 0.0319 CDK8,CSNK1A1,EIF2AK2 MHC_I Hyper 2.03 0.0638 PRKX,DMPK,MAPK1,PRKCH,UCKL1,PKN1 MHC_I Tumor 1.29 0.0426 BRAF,AKT2,DMPK,PCK1 MHC_I FAP 0.446 0.05 DNMT1 MHC_I Tumor 1.46 0.1 CHD3,HDAC1 MHC_I CNTF FAP 0.42 0.0333 IL6ST,STAT3 MHC_I CNTF 0.481 0.0167 FGFR2 MHC_I CNTF Hyper 0.496 0.0333 MAPK1,PIK3R2 MHC_I CNTF Tumor 1.92 0.0667 MTOR,PIK3C2A,PIK3C3,PIK3R1 MHC_I UVA-Induced MAPK FAP 0.418 0.0297 PLCB4,PDIA3,PARP4 MHC_I

UVA-Induced MAPK 2.33 0.0396 PLCD3,FGFR2,SMPD1,PARP9 MHC_I UVA-Induced MAPK Hyper 0.237 0.0198 MAPK1,PIK3R2 MHC_I UVA-Induced MAPK Tumor 2.33 0.0571 MTOR,JUN,PIK3C2A,PIK3C3,PIK3R1,PARP14 MHC_I Lipid Antigen Presentation by FAP 0.384 0.0417 PDIA3 MHC_I CD1 Lipid Antigen Presentation by Hyper 0.43 0.0417 CALR MHC_I CD1 Lipid Antigen Presentation by Tumor 1.31 0.0833 AP1G2,AP2B1 MHC_I CD1 Role of JAK1, JAK2 and TYK2 FAP 0.384 0.0417 STAT3 MHC_I in Interferon Role of JAK1, JAK2 and TYK2 Tumor 1.31 0.0833 IFNGR2,IFNAR2 MHC_I in Interferon Thrombopoietin FAP 0.378 0.0308 STAT3,PRKD3 MHC_I Thrombopoietin 1.16 0.0308 STAT5A,FGFR2 MHC_I Thrombopoietin Hyper 1.44 0.0615 STAT5A,MAPK1,PRKCH,PIK3R2 MHC_I Thrombopoietin Tumor 1.81 0.0615 JUN,PIK3C2A,PIK3C3,PIK3R1 MHC_I T Cell Receptor FAP 0.373 0.0278 BTK,PTPRH,PPP3CA MHC_I T Cell Receptor 0.791 0.0185 PTPRH,FGFR2 MHC_I T Cell Receptor Hyper 0.466 0.0278 MAPK1,PIK3R2,NFATC4 MHC_I T Cell Receptor Tumor 1.65 0.0463 JUN,PIK3C2A,PIK3C3,PIK3R1,RASA1 MHC_I Remodeling of Epithelial Adherens Junctions Remodeling of Epithelial Adherens Junctions FAP 0.37 0.0303 ACTR2,CLIP1 MHC_I Hyper 0.877 0.0455 DNM1,HGS,ACTN1 MHC_I

Remodeling of Epithelial Adherens Junctions Neuropathic Pain In Dorsal Horn Neurons Neuropathic Pain In Dorsal Horn Neurons Neuropathic Pain In Dorsal Horn Neurons Neuropathic Pain In Dorsal Horn Neurons Tumor 1.78 0.0606 TUBB4B,ZYX,CTNNB1,CTNND1 MHC_I FAP 0.344 0.0265 PLCB4,PDIA3,PRKD3 MHC_I 0.76 0.0177 PLCD3,FGFR2 MHC_I Hyper 1.18 0.0442 CAMK1,MAPK1,ITPR2,PRKCH,PIK3R2 MHC_I Tumor 1.05 0.0351 PIK3C2A,PIK3C3,PIK3R1,ITPR3 MHC_I HGF FAP 0.339 0.0263 ELF3,STAT3,PRKD3 MHC_I HGF 0.754 0.0175 ELF4,FGFR2 MHC_I HGF Hyper 1.65 0.0526 PTK2,RAPGEF1,MAP3K11,MAPK1,PRKCH,PIK3R2 MHC_I HGF Tumor 1.57 0.0439 AKT2,JUN,PIK3C2A,PIK3C3,PIK3R1 MHC_I GM-CSF FAP 0.32 0.0274 STAT3,PPP3CA MHC_I GM-CSF 0.413 0.0137 FGFR2 MHC_I GM-CSF Hyper 0.388 0.0274 MAPK1,PIK3R2 MHC_I GM-CSF Tumor 1.64 0.0548 AKT2,PIK3C2A,PIK3C3,PIK3R1 MHC_I Tight Junction FAP 0.305 0.0241 EPB41,CSTF1,TJP1,MYLK MHC_I Tight Junction Hyper 2.86 0.0602 EPB41,MYH9,TGFBR1,TNFRSF1A,NECTIN3,MARK 2,CPSF1,CASK,NAPA,NECTIN2 MHC_I Tight Junction Tumor 1.43 0.0361 AKT2,JUN,NECTIN3,STX4,CTNNB1,PTEN MHC_I 14-3-3-mediated FAP 0.267 0.0233 PLCB4,PDIA3,PRKD3 MHC_I

14-3-3-mediated 14-3-3-mediated Hyper 0.673 0.0155 PLCD3,FGFR2 MHC_I 1.42 0.0465 TSC1,MAPK1,TNFRSF1A,TSC2,PRKCH,PIK3R2 MHC_I 14-3-3-mediated Tumor 1.89 0.0462 AKT2,JUN,PIK3C2A,TUBB4B,PIK3C3,PIK3R1 MHC_I Prolactin FAP 0.262 0.0241 STAT3,PRKD3 MHC_I Prolactin 0.975 0.0241 STAT5A,FGFR2 MHC_I Prolactin Hyper 1.12 0.0482 STAT5A,MAPK1,PRKCH,PIK3R2 MHC_I Prolactin Tumor 2.11 0.0602 JUN,PIK3C2A,PIK3C3,PIK3R1,IRF1 MHC_I JAK/Stat FAP 0.262 0.0241 PIAS2,STAT3 MHC_I JAK/Stat 0.975 0.0241 STAT5A,FGFR2 MHC_I JAK/Stat Hyper 0.672 0.0361 STAT5A,MAPK1,PIK3R2 MHC_I JAK/Stat Tumor 3.64 0.0843 AKT2,MTOR,JUN,PIK3C2A,PIK3C3,PIK3R1,PTPN1 MHC_I P2Y Purigenic Receptor Pathway P2Y Purigenic Receptor Pathway P2Y Purigenic Receptor Pathway P2Y Purigenic Receptor Pathway Role of NFAT in Regulation of the Immune Response FAP 0.259 0.0229 PLCB4,PDIA3,PRKD3 MHC_I 0.663 0.0153 PLCD3,FGFR2 MHC_I Hyper 0.969 0.0382 MAPK1,ADCY3,ADCY6,PRKCH,PIK3R2 MHC_I Tumor 1.33 0.0379 AKT2,JUN,PIK3C2A,PIK3C3,PIK3R1 MHC_I FAP 0.252 0.0222 BTK,PLCB4,CSNK1A1,PPP3CA MHC_I

Role of NFAT in Regulation of the Immune Response Role of NFAT in Regulation of the Immune Response Hyper 0.58 0.0278 MAPK1,CSNK1G2,ITPR2,PIK3R2,NFATC4 MHC_I Tumor 1.74 0.0387 AKT2,JUN,PIK3C2A,PIK3C3,PIK3R1,ITPR3,CABIN1 MHC_I PDGF FAP 0.229 0.0222 STAT3,EIF2AK2 MHC_I PDGF 0.344 0.0111 FGFR2 MHC_I PDGF Hyper 0.287 0.0222 MAPK1,PIK3R2 MHC_I PDGF Tumor 1.97 0.0556 JUN,PIK3C2A,PIK3C3,PIK3R1,RASA1 MHC_I IL-9 FAP 0.199 0.0222 STAT3 MHC_I IL-9 1.44 0.0444 STAT5A,FGFR2 MHC_I IL-9 Hyper 0.672 0.0444 STAT5A,PIK3R2 MHC_I IL-9 Tumor 1.54 0.0667 PIK3C2A,PIK3C3,PIK3R1 MHC_I Glucocorticoid Receptor Glucocorticoid Receptor Hyper 0.914 0.0141 PBRM1,STAT5A,FGFR2,SMARCD1 MHC_I 0.745 0.0282 STAT5A,TGFBR1,MAPK1,SMARCB1,PIK3R2,NFAT C4,HLTF,MED14 MHC_I Glucocorticoid Receptor Tumor 3.46 0.0456 PBRM1,AKT2,PIK3C2A,PIK3R1,PCK1,SMARCA4,J UN,POLR2A,TAF1,SMARCA2,ERCC3,PIK3C3,NCO R1 MHC_I Neuregulin Neuregulin Hyper 0.359 0.0116 STAT5A MHC_I 1.61 0.0581 STAT5A,MAPK1,PRKCH,ERBB2,PIK3R2 MHC_I

Neuregulin Tumor 1.41 0.0465 AKT2,MTOR,PIK3R1,PTEN MHC_I Actin Cytoskeleton Actin Cytoskeleton Hyper 0.734 0.0135 DIAPH2,FGFR2,ARHGEF1 MHC_I 1.19 0.036 PTK2,MYH9,WASF2,MAPK1,BAIAP2,PIK3R2,GIT1, ACTN1 MHC_I Actin Cytoskeleton Tumor 0.957 0.0271 PIK3C2A,PIK3C3,PIK3R1,TRIO,ARHGEF1,NCKAP1 MHC_I Huntington's Disease Hyper 1.05 0.0336 DNM1,MAPK1,HDAC8,CASP2,PSME4,PRKCH,PIK3 R2,NAPA MHC_I Huntington's Disease Tumor 5.51 0.0625 AKT2,PIK3C2A,PIK3R1,HDAC1,APAF1,MTOR,JUN, POLR2A,PIK3C3,HTT,PSME4,TCERG1,NCOR1,RA SA1,CASP5 MHC_I p53 0.772 0.018 TOPBP1,FGFR2 MHC_I p53 Hyper 0.446 0.027 CCNG1,SIRT1,PIK3R2 MHC_I p53 Tumor 5.23 0.0901 AKT2,JUN,PIK3C2A,TOPBP1,PIK3C3,PIK3R1,HDA C1,APAF1,CTNNB1,PTEN MHC_I Erythropoietin 1.01 0.0253 STAT5A,FGFR2 MHC_I Erythropoietin Hyper 1.19 0.0506 STAT5A,MAPK1,PRKCH,PIK3R2 MHC_I Erythropoietin Tumor 2.15 0.0617 AKT2,JUN,PIK3C2A,PIK3C3,PIK3R1 MHC_I Fcγ Receptor-mediated Phagocytosis in Macrophages 0.334 0.0108 PLD1 MHC_I

and Monocytes Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes IL-8 IL-8 Hyper 0.579 0.0323 MAPK1,PRKCH,PIK3R2 MHC_I Tumor 1.31 0.043 AKT2,PLD3,PIK3R1,PTEN MHC_I Hyper 0.425 0.0102 FGFR2,PLD1 MHC_I 0.285 0.0204 PTK2,MAPK1,PRKCH,PIK3R2 MHC_I IL-8 Tumor 2.58 0.0459 BRAF,AKT2,ARRB2,MTOR,PLD3,JUN,PIK3C2A,PIK 3C3,PIK3R1 MHC_I IL-12 and Production in Macrophages IL-12 and Production in Macrophages IL-12 and Production in Macrophages Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses FcγRIIB in B Lymphocytes FcγRIIB in B Lymphocytes LPS-stimulated MAPK 0.604 0.0139 FGFR2,MST1R MHC_I Hyper 0.282 0.0208 MAPK1,PRKCH,PIK3R2 MHC_I Tumor 1.69 0.0417 AKT2,JUN,PIK3C2A,PIK3C3,PIK3R1,IRF1 MHC_I Hyper 1.24 0.0229 OAS2,FGFR2,TLR3 MHC_I 0.615 0.0305 MAPK1,PRKCH,PIK3R2,OAS3 MHC_I Tumor 0.887 0.0305 PIK3C2A,PIK3C3,PIK3R1,C1QA MHC_I 0.525 0.0189 FGFR2 MHC_I Tumor 1.36 0.0566 PIK3C2A,PIK3C3,PIK3R1 MHC_I 0.359 0.0116 FGFR2 MHC_I

LPS-stimulated MAPK LPS-stimulated MAPK CD40 CD40 Hyper 0.643 0.0349 MAPK1,PRKCH,PIK3R2 MHC_I Tumor 1.4 0.046 JUN,PIK3C2A,PIK3C3,PIK3R1 MHC_I Hyper 0.395 0.013 FGFR2 MHC_I 0.361 0.026 MAPK1,PIK3R2 MHC_I CD40 Tumor 1.55 0.0513 JUN,PIK3C2A,PIK3C3,PIK3R1 MHC_I CXCR4 Hyper 1.41 0.0427 PTK2,MAPK1,ITPR2,ADCY3,ADCY6,PRKCH,PIK3R 2 MHC_I CXCR4 Tumor 1.45 0.0366 AKT2,JUN,PIK3C2A,PIK3C3,PIK3R1,ITPR3 MHC_I CD28 in T Helper Cells CD28 in T Helper Cells CD28 in T Helper Cells IL-15 IL-15 0.244 0.00794 FGFR2 MHC_I Hyper 0.361 0.0238 ITPR2,PIK3R2,NFATC4 MHC_I Tumor 1.94 0.0472 AKT2,JUN,PIK3C2A,PIK3C3,PIK3R1,ITPR3 MHC_I Hyper 1.04 0.0263 STAT5A,FGFR2 MHC_I 1.24 0.0526 PTK2,STAT5A,MAPK1,PIK3R2 MHC_I IL-15 Tumor 1.58 0.0526 AKT2,PIK3C2A,PIK3C3,PIK3R1 MHC_I Virus Entry via Endocytic Pathways Virus Entry via Endocytic Pathways Hyper 0.305 0.0098 FGFR2 MHC_I 0.508 0.0294 DNM1,PRKCH,PIK3R2 MHC_I

Virus Entry via Endocytic Pathways Reelin in Neurons Reelin in Neurons Tumor 2.39 0.0588 FLNB,AP1G2,PIK3C2A,PIK3C3,PIK3R1,AP2B1 MHC_I Hyper 0.902 0.0217 FGFR2,ARHGEF1 MHC_I 0.277 0.0217 MAP3K11,PIK3R2 MHC_I Reelin in Neurons Tumor 1.32 0.0435 PIK3C2A,PIK3C3,PIK3R1,ARHGEF1 MHC_I Endothelin-1 Endothelin-1 Hyper 0.909 0.0164 PLCD3,FGFR2,PLD1 MHC_I 1.2 0.0383 MAPK1,ITPR2,CASP2,ADCY3,ADCY6,PRKCH,PIK3 R2 MHC_I Endothelin-1 Tumor 2.18 0.043 BRAF,PLD3,JUN,PIK3C2A,PIK3C3,PIK3R1,ITPR3,C ASP5 MHC_I Relaxin 0.199 0.00671 FGFR2 MHC_I Relaxin Hyper 0.495 0.0268 MAPK1,ADCY3,ADCY6,PIK3R2 MHC_I Relaxin Tumor 2.14 0.0464 BRAF,AKT2,JUN,PIK3C2A,PIK3C3,PIK3R1,NPR2 MHC_I Renin-Angiotensin Renin-Angiotensin Hyper 0.26 0.0084 FGFR2 MHC_I 2.1 0.0588 PTK2,MAPK1,ITPR2,ADCY3,ADCY6,PRKCH,PIK3R 2 MHC_I Renin-Angiotensin Tumor 1.47 0.0413 JUN,PIK3C2A,PIK3C3,PIK3R1,ITPR3 MHC_I icos-icosl in T Helper Cells 0.265 0.00855 FGFR2 MHC_I

icos-icosl in T Helper Cells icos-icosl in T Helper Cells Molecular Mechanisms of Cancer Molecular Mechanisms of Cancer Hyper 0.41 0.0256 ITPR2,PIK3R2,NFATC4 MHC_I Tumor 2.09 0.0508 AKT2,PIK3C2A,PIK3C3,PIK3R1,ITPR3,PTEN MHC_I Hyper 0.352 0.00815 ZBTB17,FGFR2,ARHGEF1 MHC_I 1.28 0.0326 PTK2,RAPGEF1,E2F4,TGFBR1,MAPK1,FANCD2,A DCY3,ADCY6,PRKCH,PIK3R2,LRP1,NBN MHC_I Molecular Mechanisms of Cancer Tumor 2.03 0.0324 BRAF,AKT2,JUN,TFDP1,PIK3C2A,PIK3C3,PIK3R1, APAF1,ARHGEF1,CTNNB1,RASA1,CTNND1 MHC_I FLT3 in Hematopoietic Progenitor Cells FLT3 in Hematopoietic Progenitor Cells FLT3 in Hematopoietic Progenitor Cells GNRH Hyper 0.984 0.0244 STAT5A,FGFR2 MHC_I 0.683 0.0366 STAT5A,MAPK1,PIK3R2 MHC_I Tumor 2.13 0.061 AKT2,MTOR,PIK3C2A,PIK3C3,PIK3R1 MHC_I Hyper 2.51 0.063 PTK2,DNM1,MAP3K11,MAPK1,ITPR2,ADCY3,ADC Y6,PRKCH MHC_I GNRH Tumor 0.25 0.0157 JUN,ITPR3 MHC_I Germ Cell-Sertoli Cell Hyper 2.27 0.0533 PTK2,TGFBR1,MAP3K11,MAPK1,TNFRSF1A,NECT MHC_I Junction IN3,PIK3R2,ACTN1,NECTIN2

Germ Cell-Sertoli Cell Junction Tumor 3.67 0.0592 PIK3C2A,TUBB4B,PIK3C3,PIK3R1,NECTIN3,ILK,ZY X,CLINT1,CTNNB1,CTNND1 MHC_I Glioma 0.285 0.00917 FGFR2 MHC_I Glioma Hyper 1.23 0.0459 E2F4,CAMK1,MAPK1,PRKCH,PIK3R2 MHC_I Glioma Tumor 2.88 0.0631 AKT2,MTOR,TFDP1,PIK3C2A,PIK3C3,PIK3R1,PTE N MHC_I Type II Diabetes Mellitus Type II Diabetes Mellitus Type II Diabetes Mellitus 0.694 0.016 FGFR2,SMPD1 MHC_I Hyper 0.661 0.032 MAPK1,TNFRSF1A,PRKCH,PIK3R2 MHC_I Tumor 2.57 0.0556 AKT2,ACSL3,MTOR,PIK3C2A,PIK3C3,PIK3R1,ADIP MHC_I OR1 Non-Small Cell Lung Cancer Non-Small Cell Lung Cancer Non-Small Cell Lung Cancer Production of Nitric Oxide and Reactive Oxygen Species in Macrophages Production of Nitric Oxide and Reactive Oxygen Species in Macrophages 0.395 0.013 FGFR2 MHC_I Hyper 1.22 0.0519 MAPK1,ITPR2,ERBB2,PIK3R2 MHC_I Tumor 3.01 0.0779 AKT2,TFDP1,PIK3C2A,PIK3C3,PIK3R1,ITPR3 MHC_I Hyper 0.512 0.026 MAP3K11,MAPK1,TNFRSF1A,PRKCH,PIK3R2 MHC_I Tumor 1.6 0.0363 AKT2,JUN,PIK3C2A,PIK3C3,PIK3R1,IFNGR2,IRF1 MHC_I Gα12/13 0.668 0.0154 FGFR2,ARHGEF1 MHC_I Gα12/13 Hyper 0.342 0.0231 PTK2,MAPK1,PIK3R2 MHC_I

Gα12/13 Tumor 3.13 0.0611 AKT2,JUN,PIK3C2A,PIK3C3,PIK3R1,ARHGEF1,CT NNB1,RASA1 MHC_I Colorectal Cancer Metastasis Colorectal Cancer Metastasis Hyper 0.318 0.00826 FGFR2,TLR3 MHC_I 1.02 0.0331 E2F4,TGFBR1,MAPK1,TNFRSF1A,ADCY3,ADCY6, PIK3R2,LRP1 MHC_I Colorectal Cancer Metastasis Tumor 1.98 0.037 BRAF,AKT2,JUN,PIK3C2A,PIK3C3,PIK3R1,MSH6,C TNNB1,MLH1 MHC_I Pancreatic Adenocarcinoma Pancreatic Adenocarcinoma Pancreatic Adenocarcinoma Sphingosine-1-phosphate Sphingosine-1-phosphate Sphingosine-1-phosphate Systemic Lupus Erythematosus Systemic Lupus Erythematosus 0.731 0.0169 FGFR2,PLD1 MHC_I Hyper 1.12 0.0424 E2F4,TGFBR1,MAPK1,ERBB2,PIK3R2 MHC_I Tumor 2.09 0.0508 AKT2,PLD3,TFDP1,PIK3C2A,PIK3C3,PIK3R1 MHC_I 1.32 0.0246 PLCD3,FGFR2,SMPD1 MHC_I Hyper 1.52 0.0492 PTK2,MAPK1,CASP2,ADCY3,ADCY6,PIK3R2 MHC_I Tumor 1.43 0.0403 AKT2,PIK3C2A,PIK3C3,PIK3R1,CASP5 MHC_I 0.372 0.00922 EFTUD2,FGFR2 MHC_I Tumor 1.8 0.0369 AKT2,MTOR,JUN,PIK3C2A,PIK3C3,PIK3R1,PRPF8, MHC_I SNRNP200 AMPK 2.07 0.0266 PBRM1,CPT1A,CPT1B,FGFR2,SMARCD1 MHC_I

AMPK Hyper 1.54 0.0426 TSC1,MAPK1,SMARCB1,SIRT1,TSC2,PIK3R2,M T8,HLTF MHC_I AMPK Tumor 3.66 0.0545 PBRM1,AKT2,MTOR,PIK3C2A,EEF2,SMARCA2,PIK 3C3,PIK3R1,FASN,SMARCA4,PFKM MHC_I PAK 0.311 0.01 FGFR2 MHC_I PAK Hyper 1.36 0.05 PTK2,MAPK1,EPHB3,PIK3R2,GIT1 MHC_I PAK Tumor 0.734 0.03 PIK3C2A,PIK3C3,PIK3R1 MHC_I Hereditary Breast Cancer Hereditary Breast Cancer Hereditary Breast Cancer 1.18 0.0216 PBRM1,FGFR2,SMARCD1 MHC_I Hyper 1.29 0.0432 HDAC8,FANCD2,SMARCB1,PIK3R2,HLTF,NBN MHC_I Tumor 5.9 0.0851 PBRM1,AKT2,POLR2A,PIK3C2A,SMARCA2,PIK3C MHC_I 3,PIK3R1,HDAC1,MSH6,SMARCA4,MLH1,PTEN Rac Rac Hyper 0.743 0.0172 FGFR2,PLD1 MHC_I 1.62 0.0517 PTK2,MAP3K11,MAPK1,BAIAP2,PIK3R2,PI4KA MHC_I Rac Tumor 1.54 0.0431 JUN,PIK3C2A,PIK3C3,PIK3R1,NCKAP1 MHC_I Ovarian Cancer 0.21 0.00699 FGFR2 MHC_I

Ovarian Cancer Tumor 5.03 0.0769 BRAF,AKT2,MTOR,TFDP1,PIK3C2A,PIK3C3,PIK3R 1,MSH6,CTNNB1,MLH1,PTEN MHC_I HER-2 in Breast Cancer HER-2 in Breast Cancer HER-2 in Breast Cancer Breast Cancer Regulation by Stathmin1 Breast Cancer Regulation by Stathmin1 0.351 0.0114 FGFR2 MHC_I Hyper 1.57 0.0568 TSC1,TSC2,PRKCH,ERBB2,PIK3R2 MHC_I Tumor 1.38 0.0455 AKT2,PIK3C2A,PIK3C3,PIK3R1 MHC_I Hyper 0.409 0.0099 FGFR2,ARHGEF1 MHC_I 1.38 0.0396 E2F4,CAMK1,MAPK1,ITPR2,ADCY3,ADCY6,PRKC H,PIK3R2 MHC_I Breast Cancer Regulation by Stathmin1 Tumor 1.1 0.0297 PIK3C2A,TUBB4B,PIK3C3,PIK3R1,ITPR3,ARHGEF 1 MHC_I RANK in Osteoclasts RANK in Osteoclasts RANK in Osteoclasts Glioblastoma Multiforme Glioblastoma Multiforme Glioblastoma Multiforme Nur77 in T Lymphocytes 0.314 0.0101 FGFR2 MHC_I Hyper 0.53 0.0303 MAP3K11,MAPK1,PIK3R2 MHC_I Tumor 1.78 0.05 AKT2,JUN,PIK3C2A,PIK3C3,PIK3R1 MHC_I 0.547 0.0127 PLCD3,FGFR2 MHC_I Hyper 1.08 0.038 TSC1,E2F4,MAPK1,ITPR2,TSC2,PIK3R2 MHC_I Tumor 2.59 0.0503 AKT2,MTOR,PIK3C2A,PIK3C3,PIK3R1,ITPR3,CTN MHC_I NB1,PTEN Tumor 1.36 0.0566 HDAC1,APAF1,CABIN1 MHC_I

IL-17A in Airway Cells IL-17A in Airway Cells IL-17A in Airway Cells NGF NGF 0.395 0.013 FGFR2 MHC_I Hyper 0.361 0.026 MAPK1,PIK3R2 MHC_I Tumor 2.98 0.0769 AKT2,PIK3C2A,PIK3C3,PIK3R1,MUC5B,PTEN MHC_I Hyper 0.743 0.0172 FGFR2,SMPD1 MHC_I 0.416 0.0259 MAP3K11,MAPK1,PIK3R2 MHC_I NGF Tumor 1.5 0.042 AKT2,PIK3C2A,PIK3C3,PIK3R1,TRIO MHC_I Sertoli Cell-Sertoli Cell Junction Hyper 1.31 0.0405 EPB41,MAP3K11,MAPK1,TNFRSF1A,NECTIN3,AC TN1,NECTIN2 MHC_I Sertoli Cell-Sertoli Cell Junction Tumor 2.37 0.0462 AKT2,JUN,TUBB4B,NECTIN3,ILK,CLINT1,CTNNB1, PTEN MHC_I Telomerase 0.791 0.0185 ELF4,FGFR2 MHC_I Telomerase Hyper 0.815 0.037 MAPK1,HDAC8,TEP1,PIK3R2 MHC_I Telomerase Tumor 1.65 0.0463 AKT2,PIK3C2A,PIK3C3,PIK3R1,HDAC1 MHC_I enos 0.201 0.00676 FGFR2 MHC_I enos Hyper 1.18 0.0405 NOSIP,ITPR2,ADCY3,ADCY6,PRKCH,PIK3R2 MHC_I enos Tumor 1.49 0.0373 AKT2,PIK3C2A,PIK3C3,PIK3R1,ITPR3,NOSTRIN MHC_I VEGF Family Ligand- Receptor Interactions 0.351 0.0114 FGFR2 MHC_I

VEGF Family Ligand- Receptor Interactions VEGF Family Ligand- Receptor Interactions Ephrin A Ephrin A Hyper 0.624 0.0341 MAPK1,PRKCH,PIK3R2 MHC_I Tumor 1.38 0.0455 AKT2,PIK3C2A,PIK3C3,PIK3R1 MHC_I Hyper 0.481 0.0167 FGFR2 MHC_I 0.968 0.05 PTK2,PIK3R2,EPHA2 MHC_I Ephrin A Tumor 1.92 0.0667 PIK3C2A,PIK3C3,PIK3R1,EPHA2 MHC_I ErbB 0.321 0.0103 FGFR2 MHC_I ErbB Hyper 0.936 0.0412 MAPK1,PRKCH,ERBB2,PIK3R2 MHC_I ErbB Tumor 1.84 0.0515 MTOR,JUN,PIK3C2A,PIK3C3,PIK3R1 MHC_I ErbB2-ErbB3 1.12 0.0294 STAT5A,FGFR2 MHC_I ErbB2-ErbB3 Hyper 1.38 0.0588 STAT5A,MAPK1,ERBB2,PIK3R2 MHC_I ErbB2-ErbB3 Tumor 2.48 0.0735 JUN,PIK3C2A,PIK3C3,PIK3R1,PTEN MHC_I PEDF 0.366 0.0119 FGFR2 MHC_I PEDF Hyper 2.26 0.0714 HNF1B,SOD2,WASF2,MAPK1,PIK3R2,TCF12 MHC_I PEDF Tumor 1.4 0.046 AKT2,PIK3C2A,PIK3C3,PIK3R1 MHC_I UVB-Induced MAPK 0.447 0.0152 FGFR2 MHC_I

UVB-Induced MAPK Hyper 0.877 0.0455 MAPK1,PRKCH,PIK3R2 MHC_I UVB-Induced MAPK Tumor 2.53 0.0758 MTOR,JUN,PIK3C2A,PIK3C3,PIK3R1 MHC_I EGF 0.437 0.0147 FGFR2 MHC_I EGF Hyper 0.849 0.0441 MAPK1,ITPR2,PIK3R2 MHC_I EGF Tumor 5.15 0.118 AKT2,MTOR,JUN,PIK3C2A,PIK3C3,PIK3R1,ITPR3, RASA1 MHC_I SAPK/JNK 0.302 0.00971 FGFR2 MHC_I SAPK/JNK Hyper 0.501 0.0291 MINK1,MAP3K11,PIK3R2 MHC_I SAPK/JNK Tumor 1.73 0.0485 JUN,PIK3C2A,PIK3C3,PIK3R1,MAP4K5 MHC_I Nitric Oxide in the Cardiovascular System Nitric Oxide in the Cardiovascular System Nitric Oxide in the Cardiovascular System FGF FGF 0.288 0.00926 FGFR2 MHC_I Hyper 1.25 0.0463 MAPK1,ITPR2,ATP2A3,PRKCH,PIK3R2 MHC_I Tumor 1.65 0.0463 AKT2,PIK3C2A,PIK3C3,PIK3R1,ITPR3 MHC_I Hyper 0.344 0.0111 FGFR2 MHC_I 0.287 0.0222 MAPK1,PIK3R2 MHC_I FGF Tumor 1.35 0.0444 AKT2,PIK3C2A,PIK3C3,PIK3R1 MHC_I B Cell Receptor Hyper 0.568 0.0275 PTK2,MAP3K11,MAPK1,PIK3R2,NFATC4 MHC_I

B Cell Receptor Tumor 1.67 0.0374 AKT2,MTOR,JUN,PIK3C2A,PIK3C3,PIK3R1,PTEN MHC_I Insulin Receptor 0.221 0.0073 FGFR2 MHC_I Insulin Receptor Hyper 0.909 0.0365 TSC1,RAPGEF1,MAPK1,TSC2,PIK3R2 MHC_I Insulin Receptor Tumor 3 0.0584 AKT2,MTOR,PIK3C2A,PIK3C3,PIK3R1,PTPN1,STX 4,PTEN MHC_I Integrin Hyper 1.28 0.0377 PTK2,ARHGAP5,RAPGEF1,MAP3K11,MAPK1,PIK3 R2,GIT1,ACTN1 MHC_I Integrin Tumor 2.36 0.0425 BRAF,PARVB,AKT2,PIK3C2A,PIK3C3,PIK3R1,ILK,Z YX,PTEN MHC_I IGF-1 0.294 0.00943 FGFR2 MHC_I IGF-1 Hyper 0.479 0.0283 PTK2,MAPK1,PIK3R2 MHC_I IGF-1 Tumor 2.31 0.0566 AKT2,JUN,PIK3C2A,PIK3C3,PIK3R1,RASA1 MHC_I NF-κB 0.481 0.0113 FGFR2,TLR3 MHC_I NF-κB Tumor 1.31 0.0337 BRAF,AKT2,PIK3C2A,PIK3C3,PIK3R1,HDAC1 MHC_I IL-6 0.242 0.00787 FGFR2 MHC_I IL-6 Hyper 0.356 0.0236 MAPK1,TNFRSF1A,PIK3R2 MHC_I IL-6 Tumor 1.38 0.0391 AKT2,JUN,PIK3C2A,PIK3C3,PIK3R1 MHC_I Th1 Pathway 0.235 0.00769 FGFR2 MHC_I

Th1 Pathway Tumor 1.36 0.0385 PIK3C2A,PIK3C3,PIK3R1,IFNGR2,IRF1 MHC_I Calcium Hyper 2.25 0.0529 CALR,MYH9,CAMK1,MAPK1,HDAC8,ITPR2,ATP2A 3,ASPH,NFATC4 MHC_I Calcium Tumor 0.607 0.0234 HDAC1,ITPR3,ASPH,CABIN1 MHC_I Ceramide 0.894 0.0215 FGFR2,SMPD1 MHC_I Ceramide Hyper 0.272 0.0215 TNFRSF1A,PIK3R2 MHC_I Ceramide Tumor 1.91 0.0538 AKT2,JUN,PIK3C2A,PIK3C3,PIK3R1 MHC_I Lymphotoxin β Receptor Lymphotoxin β Receptor Lymphotoxin β Receptor IL-17 IL-17 0.442 0.0149 FGFR2 MHC_I Hyper 0.434 0.0299 MAPK1,PIK3R2 MHC_I Tumor 2.51 0.0746 AKT2,PIK3C2A,PIK3C3,PIK3R1,APAF1 MHC_I Hyper 0.362 0.0118 FGFR2 MHC_I 0.313 0.0235 MAPK1,PIK3R2 MHC_I IL-17 Tumor 2.79 0.0706 AKT2,JUN,PIK3C2A,PIK3C3,PIK3R1,MUC5B MHC_I CTLA4 in Cytotoxic T Lymphocytes CTLA4 in Cytotoxic T Lymphocytes IL-15 Production 0.318 0.0102 FGFR2 MHC_I Tumor 2.47 0.0612 AKT2,AP1G2,PIK3C2A,PIK3C3,PIK3R1,AP2B1 MHC_I 0.782 0.037 MST1R MHC_I

IL-15 Production Hyper 1.03 0.0741 PTK2,MAP3K11 MHC_I IL-15 Production Tumor 0.467 0.0357 IRF1 MHC_I HIF1α 0.76 0.0177 EGLN3,FGFR2 MHC_I HIF1α Tumor 1.54 0.0431 AKT2,JUN,PIK3C2A,PIK3C3,PIK3R1 MHC_I Angiopoietin 1.04 0.0263 STAT5A,FGFR2 MHC_I Angiopoietin Hyper 0.748 0.0395 PTK2,STAT5A,PIK3R2 MHC_I Angiopoietin Tumor 2.25 0.0649 AKT2,PIK3C2A,PIK3C3,PIK3R1,RASA1 MHC_I Docosahexaenoic Acid (DHA) Docosahexaenoic Acid (DHA) Docosahexaenoic Acid (DHA) HMGB1 HMGB1 0.532 0.0192 FGFR2 MHC_I Hyper 0.197 0.0192 PIK3R2 MHC_I Tumor 3 0.0962 AKT2,PIK3C2A,PIK3C3,PIK3R1,APAF1 MHC_I Hyper 0.233 0.00763 FGFR2 MHC_I 0.969 0.0382 MAPK1,TNFRSF1A,KAT6A,PIK3R2,KAT2A MHC_I HMGB1 Tumor 1.88 0.0458 AKT2,JUN,PIK3C2A,PIK3C3,PIK3R1,IFNGR2 MHC_I Polyamine Regulation in Colon Cancer Polyamine Regulation in Colon Cancer Antiproliferative Role of Somatostatin Receptor 2 Antiproliferative Role of Somatostatin Receptor 2 Hyper 0.46 0.0455 PSME4 MHC_I Tumor 1.38 0.0909 PSME4,CTNNB1 MHC_I Hyper 0.417 0.0139 FGFR2 MHC_I 0.395 0.0278 MAPK1,PIK3R2 MHC_I

Antiproliferative Role of Somatostatin Receptor 2 Melanoma Melanoma Tumor 2.37 0.0694 BRAF,PIK3C2A,PIK3C3,PIK3R1,NPR2 MHC_I Hyper 0.512 0.0182 FGFR2 MHC_I 0.547 0.0364 MAPK1,PIK3R2 MHC_I Melanoma Tumor 3.81 0.109 BRAF,AKT2,PIK3C2A,PIK3C3,PIK3R1,PTEN MHC_I Prostate Cancer 0.337 0.0109 FGFR2 MHC_I Prostate Cancer Hyper 0.277 0.0217 MAPK1,PIK3R2 MHC_I Prostate Cancer Tumor 4.11 0.0851 AKT2,MTOR,TFDP1,PIK3C2A,PIK3C3,PIK3R1,CTN NB1,PTEN MHC_I Renal Cell Carcinoma Renal Cell Carcinoma Renal Cell Carcinoma Small Cell Lung Cancer Small Cell Lung Cancer Small Cell Lung Cancer 1.01 0.0253 EGLN3,FGFR2 MHC_I Hyper 0.715 0.038 RAPGEF1,MAPK1,PIK3R2 MHC_I Tumor 2.15 0.0617 AKT2,JUN,PIK3C2A,PIK3C3,PIK3R1 MHC_I 0.967 0.0238 FGFR2,SKP2 MHC_I Hyper 0.319 0.0238 PTK2,PIK3R2 MHC_I Tumor 4.43 0.0941 AKT2,TFDP1,PIK3C2A,PIK3C3,PIK3R1,APAF1,SKP MHC_I 2,PTEN Endometrial Cancer Endometrial Cancer Hyper 0.458 0.0156 FGFR2 MHC_I 0.906 0.0469 MAPK1,ERBB2,PIK3R2 MHC_I

Endometrial Cancer Tumor 5.35 0.125 AKT2,PIK3C2A,PIK3C3,PIK3R1,ILK,CTNNB1,MLH1, PTEN MHC_I Chronic Myeloid Leukemia Chronic Myeloid Leukemia Hyper 0.823 0.0194 STAT5A,FGFR2 MHC_I 1.84 0.0583 STAT5A,E2F4,TGFBR1,MAPK1,HDAC8,PIK3R2 MHC_I Chronic Myeloid Leukemia Myc Mediated Apoptosis Myc Mediated Apoptosis ILK Tumor 2.37 0.0583 AKT2,TFDP1,PIK3C2A,PIK3C3,PIK3R1,HDAC1 MHC_I 0.427 0.0143 FGFR2 MHC_I Tumor 2.42 0.0714 AKT2,PIK3C2A,PIK3C3,PIK3R1,APAF1 MHC_I Hyper 0.785 0.0312 PTK2,MYH9,MAPK1,TNFRSF1A,PIK3R2,ACTN1 MHC_I ILK Tumor 3.85 0.0573 PARVB,FLNB,AKT2,MTOR,JUN,PIK3C2A,PIK3C3,P IK3R1,ILK,CTNNB1,PTEN MHC_I FAK 0.318 0.0102 FGFR2 MHC_I FAK Hyper 0.538 0.0306 PTK2,MAPK1,PIK3R2 MHC_I FAK Tumor 1.82 0.051 AKT2,PIK3C2A,PIK3C3,PIK3R1,PTEN MHC_I Estrogen-Dependent Breast Cancer Estrogen-Dependent Breast Cancer Hyper 1.03 0.026 STAT5A,FGFR2 MHC_I 0.737 0.039 STAT5A,MAPK1,PIK3R2 MHC_I

Estrogen-Dependent Breast Cancer Role of PI3K/AKT in the Pathogenesis of Influenza Role of PI3K/AKT in the Pathogenesis of Influenza Role of PI3K/AKT in the Pathogenesis of Influenza Antiproliferative Role of TOB in T Cell Antiproliferative Role of TOB in T Cell Antiproliferative Role of TOB in T Cell Inhibition of Angiogenesis by TSP1 Inhibition of Angiogenesis by TSP1 Mismatch Repair in Eukaryotes Role of Tissue Factor in Cancer Role of Tissue Factor in Cancer Role of Tissue Factor in Cancer Tumor 3.01 0.0779 AKT2,JUN,PIK3C2A,PIK3C3,PIK3R1,HSD17B7 MHC_I 0.413 0.0137 FGFR2 MHC_I Hyper 0.388 0.0274 MAPK1,PIK3R2 MHC_I Tumor 2.27 0.0658 AKT2,PIK3C2A,PIK3C3,PIK3R1,MLH1 MHC_I 0.797 0.0385 SKP2 MHC_I Hyper 1.06 0.0769 TGFBR1,MAPK1 MHC_I Tumor 0.493 0.0385 SKP2 MHC_I Hyper 1.64 0.0938 HSPG2,TGFBR1,MAPK1 MHC_I Tumor 1.09 0.0625 AKT2,JUN MHC_I Tumor 1.64 0.125 MSH6,MLH1 MHC_I 0.726 0.0168 STAT5A,FGFR2 MHC_I Hyper 0.399 0.0252 STAT5A,MAPK1,PIK3R2 MHC_I Tumor 2.69 0.0583 AKT2,ARRB2,MTOR,PIK3C2A,PIK3C3,PIK3R1,PTE MHC_I N inos Hyper 0.248 0.0233 MAPK1 MHC_I inos Tumor 1.57 0.0682 JUN,IFNGR2,IRF1 MHC_I Estrogen-mediated S-phase 0.829 0.0417 SKP2 MHC_I Entry Estrogen-mediated S-phase Hyper 0.43 0.0417 E2F4 MHC_I

Entry Estrogen-mediated S-phase Entry GDNF Family Ligand- Receptor Interactions Tumor 1.31 0.0833 TFDP1,SKP2 MHC_I 0.399 0.0132 FGFR2 MHC_I Hyper 0.748 0.0395 MAPK1,ITPR2,PIK3R2 MHC_I Tumor 3.04 0.0789 JUN,PIK3C2A,PIK3C3,PIK3R1,ITPR3,RASA1 MHC_I GDNF Family Ligand- Receptor Interactions GDNF Family Ligand- Receptor Interactions Diphthamide Biosynthesis Tumor 1.36 0.333 EEF2 MHC_I Thio-molybdenum Cofactor Tumor 1.83 1 MOCOS MHC_I Biosynthesis 2-ketoglutarate Tumor 2.89 0.5 DT,OGDH MHC_I Dehydrogenase Complex Palmitate Biosynthesis I Tumor 1.53 0.5 FASN MHC_I (Animals) TCA Cycle II (Eukaryotic) Tumor 2.34 0.13 ACO2,DT,OGDH MHC_I Anandamide Degradation Tumor 1.53 0.5 FAAH2 MHC_I Glycerol-3-phosphate Shuttle Tumor 1.36 0.333 GPD2 MHC_I Fatty Acid Biosynthesis Tumor 1.53 0.5 FASN MHC_I Initiation II Zymosterol Biosynthesis Tumor 2.5 0.333 HSD17B7,LBR MHC_I Glutamate Biosynthesis II Tumor 1.53 0.5 GLUD1 MHC_I Glutamate Degradation X Tumor 1.53 0.5 GLUD1 MHC_I Role of p14/p19arf in Tumor 0.611 0.0238 FGFR2 MHC_I Suppression Role of p14/p19arf in Tumor Hyper 0.255 0.0238 PIK3R2 MHC_I Suppression Role of p14/p19arf in Tumor Suppression Tumor 1.62 0.0714 PIK3C2A,PIK3C3,PIK3R1 MHC_I PI3K/AKT Hyper 1.07 0.041 TSC1,MAPK1,TSC2,PIK3R2,THEM4 MHC_I PI3K/AKT Tumor 2 0.0488 AKT2,MTOR,PIK3R1,ILK,CTNNB1,PTEN MHC_I Interferon Hyper 0.299 0.0278 MED14 MHC_I

Interferon Tumor 1.8 0.0833 IFNGR2,IFNAR2,IRF1 MHC_I IL-2 1.17 0.0312 STAT5A,FGFR2 MHC_I IL-2 Hyper 0.906 0.0469 STAT5A,MAPK1,PIK3R2 MHC_I IL-2 Tumor 2.59 0.0781 AKT2,JUN,PIK3C2A,PIK3C3,PIK3R1 MHC_I IL-4 0.359 0.0116 FGFR2 MHC_I IL-4 Hyper 0.308 0.0233 PIK3R2,NFATC4 MHC_I IL-4 Tumor 2.05 0.0581 AKT2,MTOR,PIK3C2A,PIK3C3,PIK3R1 MHC_I Neurotrophin/TRK 0.399 0.0132 FGFR2 MHC_I Neurotrophin/TRK Hyper 0.368 0.0263 MAPK1,PIK3R2 MHC_I Neurotrophin/TRK Tumor 1.58 0.0526 JUN,PIK3C2A,PIK3C3,PIK3R1 MHC_I Cancer Drug Resistance By Drug Efflux Cancer Drug Resistance By Drug Efflux Actin Nucleation by ARP- WASP Complex Actin Nucleation by ARP- WASP Complex Actin Nucleation by ARP- WASP Complex Hyper 0.617 0.0408 MAPK1,PIK3R2 MHC_I Tumor 2.23 0.0816 BRAF,AKT2,PIK3R1,PTEN MHC_I FAP 2.93 0.125 ROCK2,ROCK1,ACTR2,PPP1R12C,SOS1,BAIAP2, NCK1 Hyper 0.517 0.0536 ROCK1,NCK2,RHOQ Tumor 0.847 0.0536 ROCK1,SOS2,VASP

Estrogen Receptor FAP 2.87 0.0859 MED13,CDK8,MED20,MED15,SOS1,MED21,TBP,G TF2H1,NCOR1,MED13L,MAP2K1 Estrogen Receptor Estrogen Receptor Hyper 0.422 0.0156 MED23,MED16 0.814 0.0547 MAPK1,TRRAP,CREBBP,NCOA1,NCOR2,SMARCA 4,MED14 Estrogen Receptor Tumor 4.33 0.0938 POLR2C,MED23,POLR2A,MAPK1,ERCC3,TRRAP, SOS2,NCOR1,PCK1,MED24,TAF2,SMARCA4 RhoA FAP 2.51 0.082 ROCK2,ROCK1,ARHGAP5,ACTR2,LPAR6,BAIAP2, LPAR5,ARHGAP12,MYLK,ARHGAP1 RhoA RhoA Hyper 0.449 0.0164 ARHGEF1,PLD1 1.22 0.0656 PTK2,ROCK1,ARHGAP5,ANLN,LPAR5,ARHGAP1, PI4KA,PKN1 RhoA Tumor 0.497 0.0328 ROCK1,PIKFYVE,RAPGEF6,ARHGEF1 Cell Cycle Control of Chromosomal Replication Cell Cycle Control of Chromosomal Replication Cell Cycle Control of Chromosomal Replication Cell Cycle Control of Chromosomal Replication FAP 2.24 0.107 TOP2B,CDK12,CDK8,PRIM1,TOP2A,ORC4 0.358 0.0179 CHEK2 Hyper 0.897 0.0714 LIG1,MCM2,CDK11B,POLD1 Tumor 3.51 0.125 TOP2B,CDK12,ORC3,POLE,CDK4,MCM4,MCM7

Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis FAP 2.09 0.0561 IL6ST,PIK3C2B,FRZB,PDIA3,CSNK1A1,STAT3,RO CK1,ROCK2,CALM1 (includes others),plcb4,camk2d,fzd6,prkd3,map2k1,tc F7L2,LRP1,PPP3CA Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis Hyper 0.424 0.0132 PLCD3,FGFR2,TLR3,STAT3 0.606 0.0429 ROCK1,PLCD3,NLK,MAPK1,TNFRSF1A,PRKCD,C REBBP,DVL1,PLCB3,PRKCH,CEBPB,PIK3R2,LRP1 Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis Tumor 1 0.0363 ROCK1,AKT2,NFKBIA,JUN,MAPK1,PIK3C2A,PIK3C 3,DVL1,CTNNB1,PLCH1,LRP1 Role of BRCA1 in DNA Damage Response FAP 2.05 0.0875 ABRAXAS1,TOPBP1,RFC2,ATR,SMARCD1,SMAR CC1,NBN Role of BRCA1 in DNA Damage Response Role of BRCA1 in DNA Damage Response Hyper 1.31 0.0375 PBRM1,TOPBP1,CHEK2 1.69 0.0875 E2F4,FANCD2,SMARCB1,MSH6,HLTF,SMARCA4, NBN Role of BRCA1 in DNA Damage Response Tumor 3.26 0.1 PBRM1,RBL2,MSH6,BABAM1,ARID2,SMARCA4,ML H1,RFC3 Wnt/β-catenin FAP 1.95 0.0651 AXIN2,FRZB,APPL2,FZD6,CSNK1A1,NR5A2,TLE1, BMPR2,SOX9,TCF7L2,LRP1

Wnt/β-catenin Hyper 1.49 0.0651 CSNK1E,NLK,TGFBR1,CSNK1G2,CSNK1G3,DVL1, CREBBP,MARK2,ACVR1,DVL3,LRP1 Wnt/β-catenin Tumor 0.993 0.0414 AKT2,JUN,HDAC1,DVL1,ILK,CTNNB1,LRP1 UDP-N-acetyl-D-glucosamine Biosynthesis II Mouse Embryonic Stem Cell Pluripotency Mouse Embryonic Stem Cell Pluripotency Mouse Embryonic Stem Cell Pluripotency Mouse Embryonic Stem Cell Pluripotency FAP 1.93 0.333 GNPNAT1,PGM3 FAP 1.92 0.0762 IL6ST,PIK3C2B,SOS1,FZD6,BMPR2,STAT3,MAP2K 1,TCF7L2 1.64 0.0381 BMP4,TYK2,FGFR2,STAT3 Hyper 0.53 0.0476 MAPK1,DVL1,CREBBP,DVL3,PIK3R2 Tumor 1.94 0.0667 AKT2,MAPK1,PIK3C2A,PIK3C3,DVL1,SOS2,CTNN B1 Cell Cycle: G2/M DNA Damage Checkpoint Regulation Cell Cycle: G2/M DNA Damage Checkpoint Regulation Cell Cycle: G2/M DNA Damage Checkpoint Regulation FAP 1.86 0.102 TOP2B,TRIP12,TOP2A,CCNB2,ATR 1.05 0.0408 CHEK2,SKP2 Tumor 0.498 0.0408 TOP2B,SKP2 Valine Degradation I FAP 1.83 0.167 HIBCH,EHHADH,BCKDHB Melatonin FAP 1.78 0.0857 CALM1 (includes others),plcb4,camk2d,pdia3,map2k1,prkd3 Melatonin 0.289 0.0143 PLCD3

Melatonin Hyper 1.03 0.0714 PLCD3,MAPK1,PRKCD,PLCB3,PRKCH Melatonin Tumor 0.65 0.0429 BRAF,MAPK1,PLCH1 Oncostatin M FAP 1.78 0.118 IL6ST,SOS1,STAT3,MAP2K1 Oncostatin M 1.33 0.0588 TYK2,STAT3 Oncostatin M Hyper 0.484 0.0588 STAT5A,MAPK1 Oncostatin M Tumor 0.726 0.0588 EPAS1,MAPK1 DNA damage-induced 14-3- FAP 1.77 0.158 RAD17,CCNB2,ATR 3σ DNA damage-induced 14-3- Tumor 0.442 0.0526 AKT2 3σ GM-CSF FAP 1.7 0.0822 PIK3C2B,CAMK2D,SOS1,STAT3,MAP2K1,PPP3CA GM-CSF 0.765 0.0274 FGFR2,STAT3 GM-CSF Hyper 0.335 0.0411 ETS1,MAPK1,PIK3R2 GM-CSF Tumor 2.15 0.0822 AKT2,MAPK1,PIK3C2A,PIK3C3,RACK1,SOS2 Transcriptional Regulatory Network in Embryonic Stem Cells Transcriptional Regulatory Network in Embryonic Stem Cells Transcriptional Regulatory Network in Embryonic Stem Cells Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency FAP 1.69 0.0926 TRIM24,RIF1,KAT6A,SKIL,STAT3 Hyper 0.37 0.0185 STAT3 0.252 0.037 KAT6A,CDX2 FAP 1.61 0.0667 IL6ST,PIK3C2B,RIF1,SOS1,FZD6,BMPR2,STAT3,M AP2K1

Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency 1.46 0.0333 BMP4,TYK2,FGFR2,STAT3 Tumor 2.14 0.0667 AKT2,RIF1,MAPK1,PIK3C2A,PIK3C3,DVL1,SOS2,C TNNB1 PPARα/RXRα Activation FAP 1.58 0.0595 CAND1,PLCB4,HELZ2,PDIA3,SOS1,PRKAA1,NCO A6,BMPR2,NCOR1,MAP2K1 PPARα/RXRα Activation PPARα/RXRα Activation Hyper 0.606 0.0179 PLCD3,MED23,CPT1B 2.68 0.0833 TGFBR1,PRKAB2,MAPK1,ADCY3,CREBBP,ACVR1,ADCY6,CKAP5,NFKB2,PLCD3,HELZ2,FASN,PLCB 3,NCOR2 PPARα/RXRα Activation Tumor 4.38 0.0833 SMAD2,MED23,MAPK1,SOS2,ADIPOR1,PLCH1,CA ND1,JUN,NFKBIA,GPD2,FASN,NCOR1,GOT2,MED 24 CNTF FAP 1.51 0.0833 IL6ST,PIK3C2B,SOS1,STAT3,MAP2K1 CNTF 1.63 0.05 TYK2,FGFR2,STAT3 CNTF Tumor 1.89 0.0833 MTOR,MAPK1,PIK3C2A,PIK3C3,RPS6KB2 CCR3 in Eosinophils FAP 1.5 0.0635 ROCK2,ROCK1,PIK3C2B,CALM1 (includes others),plcb4,mylk,map2k1,prkd3 CCR3 in Eosinophils Hyper 0.839 0.0556 ROCK1,MAPK1,ITPR2,PRKCD,PLCB3,PRKCH,PIK 3R2

CCR3 in Eosinophils Tumor 1.12 0.0476 ROCK1,MAPK1,PIK3C2A,PIK3C3,RACK1,ITPR3 IL-3 FAP 1.46 0.0723 PIK3C2B,SOS1,STAT3,MAP2K1,PRKD3,PPP3CA IL-3 IL-3 Hyper 0.68 0.0241 FGFR2,STAT3 1.61 0.0843 RAPGEF1,STAT5A,FOXO1,MAPK1,PRKCD,PRKCH,PIK3R2 IL-3 Tumor 1.88 0.0723 STAT6,AKT2,JUN,MAPK1,PIK3C2A,PIK3C3 Thrombin FAP 1.46 0.0547 ROCK2,ROCK1,PIK3C2B,PLCB4,CAMK2D,PDIA3,S OS1,TBP,MYLK,MAP2K1,PRKD3 Thrombin Thrombin Hyper 0.819 0.0199 PLCD3,FGFR2,ARHGEF1,ARHGEF9 2.37 0.0746 CAMK1,MAPK1,ITPR2,ADCY3,ADCY6,NFKB2,ROC K1,PTK2,PLCD3,ARHGEF5,RHOQ,PRKCD,PLCB3, PRKCH,PIK3R2 Thrombin Tumor 1.33 0.0448 ROCK1,AKT2,MAPK1,PIK3C2A,PIK3C3,RACK1,ITP R3,ARHGEF1,PLCH1 Leptin in Obesity FAP 1.42 0.0706 PIK3C2B,PLCB4,PDIA3,PDE3B,STAT3,MAP2K1 Leptin in Obesity 1.25 0.0353 PLCD3,FGFR2,STAT3

Leptin in Obesity Hyper 1.56 0.0824 PLCD3,FOXO1,MAPK1,ADCY3,ADCY6,PLCB3,PIK 3R2 Leptin in Obesity Tumor 1.31 0.0588 AKT2,MAPK1,PIK3C2A,PIK3C3,PLCH1 Assembly of RNA Polymerase FAP 1.4 0.182 POLR1B,TBP I Complex UDP-N-acetyl-Dgalactosamine FAP 1.4 0.182 GNPNAT1,PGM3 Biosynthesis II Thrombopoietin FAP 1.38 0.0769 PIK3C2B,SOS1,STAT3,MAP2K1,PRKD3 Thrombopoietin 0.844 0.0308 FGFR2,STAT3 Thrombopoietin Hyper 1.14 0.0769 STAT5A,MAPK1,PRKCD,PRKCH,PIK3R2 Thrombopoietin Tumor 1.19 0.0615 JUN,MAPK1,PIK3C2A,PIK3C3 Gαq FAP 1.35 0.0566 ROCK2,ROCK1,BTK,PIK3C2B,CALM1 (includes others),plcb4,map2k1,prkd3,ppp3ca Gαq Gαq Hyper 0.313 0.0126 FGFR2,PLD1 1 0.0566 ROCK1,RHOQ,MAPK1,ITPR2,PRKCD,PLCB3,PRK CH,PIK3R2,NFKB2 Gαq Tumor 1.9 0.0566 ROCK1,AKT2,NFKBIA,PLD3,MAPK1,PIK3C2A,PIK3 C3,RACK1,ITPR3 Cleavage and Polyadenylation of Pre-mRNA Cleavage and Polyadenylation of Pre-mRNA FAP 1.33 0.167 CPSF6,CSTF3 0.935 0.0833 CPSF2

Cleavage and Polyadenylation Hyper 0.464 0.0833 CPSF1 of Pre-mRNA Glycogen Degradation II FAP 1.33 0.167 PGM3,PYGL Glycogen Degradation II Hyper 0.464 0.0833 PGM2L1 Chemokine FAP 1.31 0.0735 ROCK2,CALM1 (includes others),plcb4,camk2d,map2k1 Chemokine Hyper 0.685 0.0588 PTK2,CAMK1,MAPK1,PLCB3 Chemokine Tumor 0.325 0.0294 JUN,MAPK1 RAR Activation FAP 1.31 0.0535 TRIM24,SDR16C5,RDH14,GTF2H1,NCOR1,SMAR CD1,SMARCC1,MAP2K1,RDH13,PRKD3 RAR Activation Hyper 3.57 0.0909 STAT5A,MAPK1,CREBBP,ADCY3,ADCY6,SMAD6, NFKB2,PSMC5,SMARCA4,PRKCD,SMARCB1,NCO A1,PRKCH,NCOR2,PIK3R2,RXRB,HLTF RAR Activation Tumor 1.9 0.0535 PBRM1,SMAD2,AKT2,JUN,MAPK1,ERCC3,NCOR1, ARID2,SMARCA4,PTEN Acute Myeloid Leukemia Acute Myeloid Leukemia Acute Myeloid Leukemia FAP 1.28 0.0652 PIK3C2B,SOS1,STAT3,MAP2K1,SPI1,TCF7L2 Hyper 0.615 0.0217 FGFR2,STAT3 0.407 0.0435 STAT5A,MAPK1,PIK3R2,NFKB2

Acute Myeloid Leukemia Role of NFAT in Cardiac Hypertrophy Tumor 2.86 0.087 BRAF,AKT2,MTOR,MAPK1,PIK3C2A,PIK3C3,SOS2,RPS6KB2 FAP 1.27 0.0509 IL6ST,PIK3C2B,CALM1 (includes others),plcb4,camk2d,pdia3,sos1,csnk1a1,m AP2K1,PRKD3,PPP3CA Role of NFAT in Cardiac Hypertrophy Hyper 1.43 0.0602 PLCD3,TGFBR1,CAMK1,MAPK1,HDAC8,ITPR2,PR KCD,ADCY3,ADCY6,PLCB3,PRKCH,PIK3R2,HDAC 5 Role of NFAT in Cardiac Hypertrophy Tumor 1.51 0.0463 AKT2,MAPK1,PIK3C2A,PIK3C3,HDAC1,RACK1,ITP R3,SOS2,PLCH1,CABIN1 Aldosterone in Epithelial Cells FAP 1.24 0.0539 PIK3C2B,PLCB4,PDIA3,SLC12A2,HSPH1,SOS1,DN AJC12,MAP2K1,PRKD3 Aldosterone in Epithelial Cells Aldosterone in Epithelial Cells Hyper 0.611 0.018 PLCD3,DNAJC13,FGFR2 2.28 0.0778 PLCD3,MAPK1,DNAJB4,ITPR2,PRKCD,DNAJC12,H SPB11,PLCB3,PRKCH,NR3C2,DNAJB6,PIK3R2,PI4 KA Aldosterone in Epithelial Cells Tumor 1.01 0.0419 MAPK1,PIK3C2A,PIK3C3,ITPR3,SOS2,PIKFYVE,PL CH1

Protein Kinase A FAP 1.22 0.0443 PTPRD,PDIA3,AKAP9,MYLK,PYGL,ROCK1,ROCK2,CALM1 (includes others),plcb4,camk2d,pde3b,dusp11,pgp,prk D3,MAP2K1,TCF7L2,PPP3CA Protein Kinase A Protein Kinase A Hyper 0.255 0.0104 PLCD3,PTPN2,DUSP11,PTPRR 1.13 0.0495 FLNB,TGFBR1,PHKG2,MAPK1,PTPN23,ITPR2,CR EBBP,ADCY3,ADCY6,PTPN3,NFKB2,ROCK1,PTK2,PLCD3,PRKCD,PLCB3,PRKCH,PTPN21,DUSP16 Protein Kinase A Tumor 2.74 0.0495 ANAPC2,FLNB,PTPRK,MAPK1,AKAP9,RACK1,PTP RF,PLCH1,PTEN,ROCK1,HIST1H1B,BRAF,PHKB,N FKBIA,ITPR3,PTPN1,ANAPC5,CTNNB1,VASP Sumoylation Pathway FAP 1.2 0.0625 RANBP2,DAXX,SENP6,RFC2,SENP3,SP100 Sumoylation Pathway Hyper 0.944 0.0625 ETS1,TDG,RHOQ,SIRT1,CREBBP,NFKB2 Sumoylation Pathway Tumor 1.6 0.0625 RNF4,SAE1,NFKBIA,JUN,HDAC1,RFC3 ATM FAP 1.19 0.0619 HERC2,TOPBP1,RAD17,CCNB2,ATR,NBN ATM 0.582 0.0206 TOPBP1,CHEK2

ATM Hyper 1.73 0.0825 SMC3,HP1BP3,RNF168,FANCD2,TRRAP,CREBBP, TLK2,NBN ATM Tumor 1.11 0.0515 HERC2,NFKBIA,JUN,SMC2,TRRAP PI3K in B Lymphocytes FAP 1.11 0.0556 BTK,CALM1 (includes others),plcb4,camk2d,pdia3,map2k1,ppp3ca PI3K in B Lymphocytes PI3K in B Lymphocytes Hyper 0.572 0.0476 PLCD3,MAPK1,ITPR2,PLCB3,PIK3R2,NFKB2 Tumor 1.55 0.0556 AKT2,NFKBIA,JUN,MAPK1,ITPR3,PLCH1,PTEN Protein Ubiquitination Pathway FAP 1.05 0.0455 UBE2A,UBE2Q1,MED20,USP15,UBE3B,HSPH1,DN AJC12,USP54,USP30,USP33,USP34,UBE3A Protein Ubiquitination Pathway 1.71 0.0265 PAN2,PSMD10,USP5,UCHL5,DNAJC13,AMFR,SKP 2 Protein Ubiquitination Pathway Hyper 0.9 0.0492 USP14,DNAJB4,UBR2,DNAJC12,BIRC6,THOP1,PS MC5,USP48,PSMD11,HSPB11,DNAJB6,USP34,BIR C2 Protein Ubiquitination Pathway Tumor 2.84 0.0568 ANAPC2,USP15,USP5,HLA- A,USP36,USP9X,BIRC6,USP54,USP48,SKP2,USP3 2,PSMD12,ANAPC5,SMURF2,UBA1 p70s6k FAP 1.05 0.0534 BTK,PIK3C2B,PLCB4,PDIA3,SOS1,MAP2K1,PRKD 3

p70s6k p70s6k Hyper 0.82 0.0229 PLCD3,FGFR2,PLD1 0.778 0.0534 PLCD3,MAPK1,PRKCD,PLCB3,PRKCH,PIK3R2,BC AP31 p70s6k Tumor 1.93 0.0611 AKT2,MTOR,MAPK1,PIK3C2A,EEF2,PIK3C3,SOS2, PLCH1 FLT3 in Hematopoietic Progenitor Cells FLT3 in Hematopoietic Progenitor Cells FLT3 in Hematopoietic Progenitor Cells FLT3 in Hematopoietic Progenitor Cells FAP 1.02 0.0602 PIK3C2B,SOS1,STAT3,MAP2K1,EIF4E Hyper 0.68 0.0241 FGFR2,STAT3 0.494 0.0482 STAT5A,MAPK1,CREBBP,PIK3R2 Tumor 2.49 0.0843 STAT6,AKT2,MTOR,MAPK1,PIK3C2A,PIK3C3,SOS 2 Prolactin FAP 1.02 0.0602 PIK3C2B,SOS1,STAT3,MAP2K1,PRKD3 Prolactin Prolactin Hyper 0.68 0.0241 FGFR2,STAT3 1.61 0.0843 STAT5A,MAPK1,PRKCD,CREBBP,PRKCH,CEBPB, PIK3R2 Prolactin Tumor 1.88 0.0723 JUN,MAPK1,PIK3C2A,PIK3C3,SOS2,IRF1 JAK/Stat FAP 1.02 0.0602 PIK3C2B,PIAS2,SOS1,STAT3,MAP2K1 JAK/Stat 1.27 0.0361 TYK2,FGFR2,STAT3

JAK/Stat Hyper 0.801 0.0602 STAT5A,MAPK1,CEBPB,PIK3R2,NFKB2 JAK/Stat Tumor 3.87 0.108 STAT6,AKT2,MTOR,JUN,MAPK1,PIK3C2A,PIK3C3, PTPN1,SOS2 T Cell Receptor FAP 1.01 0.0556 BTK,PIK3C2B,CALM1 (includes others),sos1,map2k1,ppp3ca T Cell Receptor Tumor 1.87 0.0648 NFKBIA,JUN,MAPK1,PIK3C2A,PIK3C3,SOS2,RASA 1 trna Charging FAP 1 0.0789 EARS2,IARS,FARSB trna Charging 0.489 0.0263 VARS trna Charging Hyper 2.03 0.132 YARS,VARS2,TARS,SARS2,IARS trna Charging Tumor 1.23 0.0789 WARS,TARS2,EPRS Gα12/13 FAP 0.993 0.0519 ROCK2,ROCK1,BTK,PIK3C2B,LPAR6,LPAR5,MAP 2K1 Gα12/13 0.394 0.0148 FGFR2,ARHGEF1 Gα12/13 Hyper 0.493 0.0444 PTK2,ROCK1,MAPK1,LPAR5,PIK3R2,NFKB2 Gα12/13 Tumor 2.89 0.0741 ROCK1,AKT2,NFKBIA,JUN,MAPK1,PIK3C2A,PIK3C 3,ARHGEF1,CTNNB1,RASA1 Gap Junction FAP 0.963 0.0471 PIK3C2B,PLCB4,PDIA3,TJP1,SOS1,CSNK1A1,MAP 2K1,PRKD3,PPP3CA Gap Junction 0.233 0.0105 PLCD3,FGFR2

Gap Junction Hyper 2.58 0.0785 TUBB3,MAPK1,ITPR2,CSNK1G2,CSNK1G3,TUBG1,ADCY3,ADCY6,CSNK1E,PLCD3,TUBB6,PRKCD,P LCB3,PRKCH,PIK3R2 Gap Junction Tumor 2.27 0.0576 AKT2,TUBB3,MAPK1,PIK3C2A,TUBB4B,PIK3C3,IT PR3,SOS2,CTNNB1,NPR2,PLCH1 Glioma FAP 0.943 0.0531 PIK3C2B,CALM1 (includes others),camk2d,sos1,map2k1,prkd3 Glioma Hyper 1.02 0.0619 E2F4,CAMK1,MAPK1,PRKCD,CDKN2C,PRKCH,PIK 3R2 Glioma Tumor 3.5 0.0885 AKT2,RBL2,MTOR,TFDP1,MAPK1,PIK3C2A,PIK3C 3,SOS2,CDK4,PTEN Pyridoxal 5'-phosphate Salvage Pathway Pyridoxal 5'-phosphate Salvage Pathway FAP 0.93 0.0625 CDK8,PRKAA1,CSNK1A1,MAP2K1 Hyper 2.2 0.109 PRKX,DMPK,MAPK1,PRKCD,GRK6,PRKCH,PKN1 Pyridoxal 5'-phosphate Tumor 2.43 0.0938 BRAF,AKT2,DMPK,MAPK1,CDK4,NEK2 Salvage Pathway HGF FAP 0.929 0.0526 PIK3C2B,ELF3,SOS1,STAT3,MAP2K1,PRKD3 HGF 0.95 0.0263 ELF4,FGFR2,STAT3

HGF Hyper 1.36 0.0702 PTK2,ETS1,RAPGEF1,MAP3K11,MAPK1,PRKCD,P RKCH,PIK3R2 HGF Tumor 1.29 0.0526 AKT2,JUN,MAPK1,PIK3C2A,PIK3C3,SOS2 UVB-Induced MAPK FAP 0.895 0.0606 PIK3C2B,MAP2K1,PRKD3,EIF4E UVB-Induced MAPK 0.307 0.0152 FGFR2 UVB-Induced MAPK Hyper 0.716 0.0606 MAPK1,PRKCD,PRKCH,PIK3R2 UVB-Induced MAPK Tumor 1.72 0.0758 MTOR,JUN,MAPK1,PIK3C2A,PIK3C3 ErbB2-ErbB3 FAP 0.86 0.0588 PIK3C2B,SOS1,STAT3,MAP2K1 ErbB2-ErbB3 1.49 0.0441 TYK2,FGFR2,STAT3 ErbB2-ErbB3 Hyper 1.07 0.0735 STAT5A,FOXO1,MAPK1,ERBB2,PIK3R2 ErbB2-ErbB3 Tumor 2.3 0.0882 JUN,MAPK1,PIK3C2A,PIK3C3,SOS2,PTEN EGF FAP 0.86 0.0588 PIK3C2B,SOS1,STAT3,MAP2K1 EGF 0.813 0.0294 FGFR2,STAT3 EGF Hyper 0.38 0.0441 MAPK1,ITPR2,PIK3R2 EGF Tumor 4.56 0.132 AKT2,MTOR,JUN,MAPK1,PIK3C2A,PIK3C3,ITPR3, SOS2,RASA1

Breast Cancer Regulation by Stathmin1 FAP 0.838 0.0441 ROCK2,ROCK1,PIK3C2B,CALM1 (includes others),plcb4,camk2d,sos1,map2k1,prkd3 Breast Cancer Regulation by Stathmin1 Breast Cancer Regulation by Stathmin1 Hyper 0.459 0.0147 FGFR2,ARHGEF1,ARHGEF9 2.32 0.0735 TUBB3,E2F4,CAMK1,MAPK1,ITPR2,TUBG1,ADCY3,ADCY6,ROCK1,ARHGEF5,TUBB6,PRKCD,PLCB3, PRKCH,PIK3R2 Breast Cancer Regulation by Stathmin1 Tumor 2.06 0.0539 ROCK1,TUBB3,MAPK1,PIK3C2A,TUBB4B,PIK3C3, ARHGEF7,RACK1,ITPR3,SOS2,ARHGEF1 ErbB FAP 0.81 0.0515 PIK3C2B,SOS1,NCK1,MAP2K1,PRKD3 ErbB ErbB Hyper 0.199 0.0103 FGFR2 1.3 0.0722 NCK2,FOXO1,MAPK1,PRKCD,PRKCH,ERBB2,PIK3 R2 ErbB Tumor 1.58 0.0619 MTOR,JUN,MAPK1,PIK3C2A,PIK3C3,SOS2 TR/RXR Activation FAP 0.797 0.051 PIK3C2B,PDE3B,NCOA6,NCOR1,THRA TR/RXR Activation Hyper 1.28 0.0714 SREBF1,FASN,NCOA1,STRBP,PIK3R2,NCOR2,RX RB

TR/RXR Activation Tumor 3.32 0.0918 SLC16A3,AKT2,MTOR,PIK3C2A,SREBF1,PIK3C3,F ASN,NCOR1,PCK1 Axonal Guidance FAP 0.796 0.0382 ACTR2,PIK3C2B,PDIA3,NCK1,EIF4E,ROCK1,HER C2,ROCK2,PLCB4,MICAL1,SOS1,BAIAP2,MKNK1, FZD6,PRKD3,MAP2K1,PPP3CA Axonal Guidance Hyper 1.24 0.0494 TUBB3,ADAM17,MAPK1,NTN4,TUBG1,SEMA6A,PL XNA2,GIT1,RAC3,ROCK1,NCK2,PTK2,PLCD3,TUB B6,PRKCD,PLCB3,EPHB3,PRKCH,PLXNB2,ERBB2,PIK3R2,EPHA2 Axonal Guidance Tumor 2.06 0.0427 TUBB3,AKT2,MAPK1,PIK3C2A,TUBB4B,ARHGEF7, SOS2,RACK1,PLCH1,ROCK1,HERC2,PIK3C3,PLX NB1,LNPEP,CHMP1A,RASA1,EPHA2,VASP,FARP2 Role of NFAT in Regulation of the Immune Response FAP 0.79 0.0442 BTK,PIK3C2B,CALM1 (includes others),plcb4,sos1,csnk1a1,map2k1,ppp3ca Role of NFAT in Regulation of the Immune Response Hyper 0.543 0.0442 CSNK1E,MAPK1,CSNK1G2,ITPR2,CSNK1G3,PLCB 3,PIK3R2,NFKB2

Role of NFAT in Regulation of the Immune Response Tumor 2.44 0.0608 AKT2,NFKBIA,JUN,MAPK1,PIK3C2A,HLA- A,PIK3C3,RACK1,ITPR3,SOS2,CABIN1 CREB in Neurons FAP 0.786 0.0429 PIK3C2B,CALM1 (includes others),plcb4,camk2d,pdia3,sos1,tbp,map2k1,prkd3 CREB in Neurons Hyper 0.722 0.0476 PLCD3,MAPK1,ITPR2,PRKCD,CREBBP,ADCY3,AD CY6,PLCB3,PRKCH,PIK3R2 CREB in Neurons Tumor 1.58 0.0476 AKT2,POLR2C,POLR2A,MAPK1,PIK3C2A,PIK3C3, RACK1,ITPR3,SOS2,PLCH1 Role of JAK family kinases in IL-6-type Cytokine Role of JAK family kinases in IL-6-type Cytokine FAP 0.782 0.08 IL6ST,STAT3 1.57 0.08 TYK2,STAT3 Hyper 0.673 0.08 STAT5A,MAPK1 Tumor 0.351 0.04 MAPK1 Role of JAK family kinases in IL-6-type Cytokine Role of JAK family kinases in IL-6-type Cytokine VEGF FAP 0.772 0.05 ROCK2,ROCK1,PIK3C2B,SOS1,MAP2K1 VEGF Hyper 0.882 0.06 PTK2,ROCK1,FOXO1,MAPK1,PIK3R2,ACTN1 VEGF Tumor 1.53 0.06 ROCK1,AKT2,MAPK1,PIK3C2A,PIK3C3,SOS2 EIF2 FAP 0.769 0.0425 PIK3C2B,PTBP1,SOS1,EIF5B,EIF4G3,RPS17,EIF2 AK3,MAP2K1,EIF4E

EIF2 Tumor 2.37 0.0566 EIF2AK1,EIF2AK4,PTBP1,AKT2,WARS,MAPK1,PIK 3C2A,SREBF1,PIK3C3,EIF5B,SOS2,EIF4G1 Integrin FAP 0.769 0.0425 ROCK1,ARHGAP5,PIK3C2B,ACTR2,SOS1,MYLK,IT GA1,NCK1,MAP2K1 Integrin Hyper 1.2 0.0566 PTK2,ROCK1,NCK2,ARHGAP5,RAPGEF1,RHOQ,M AP3K11,MAPK1,PIK3R2,GIT1,RAC3,ACTN1 Integrin Tumor 4.39 0.0755 AKT2,MAPK1,PIK3C2A,ARHGEF7,SOS2,PIKFYVE,I LK,TLN1,PTEN,ROCK1,BRAF,PARVB,PIK3C3,ZYX, ITGA1,VASP Assembly of RNA Polymerase II Complex Assembly of RNA Polymerase II Complex GDNF Family Ligand- Receptor Interactions GDNF Family Ligand- Receptor Interactions GDNF Family Ligand- Receptor Interactions GDNF Family Ligand- Receptor Interactions Superpathway of Cholesterol Biosynthesis Superpathway of Cholesterol Biosynthesis FAP 0.746 0.06 TBP,GTF2H1,GTF2E2 Tumor 1.54 0.08 POLR2C,POLR2A,ERCC3,TAF2 FAP 0.739 0.0526 PIK3C2B,SOS1,NCK1,MAP2K1 0.265 0.0132 FGFR2 Hyper 0.311 0.0395 MAPK1,ITPR2,PIK3R2 Tumor 2.71 0.0921 JUN,MAPK1,PIK3C2A,PIK3C3,ITPR3,SOS2,RASA1 FAP 0.73 0.0741 DHCR7,ACAT2 Hyper 0.213 0.037 LBR

Superpathway of Cholesterol Biosynthesis Non-Small Cell Lung Cancer Non-Small Cell Lung Cancer Non-Small Cell Lung Cancer Non-Small Cell Lung Cancer Tumor 2.47 0.148 PMVK,HSD17B7,HMGCR,LBR FAP 0.725 0.0519 STK4,PIK3C2B,SOS1,MAP2K1 0.261 0.013 FGFR2 Hyper 0.899 0.0649 MAPK1,ITPR2,ERBB2,PIK3R2,RXRB Tumor 3.37 0.104 AKT2,TFDP1,MAPK1,PIK3C2A,PIK3C3,ITPR3,SOS 2,CDK4 Adipogenesis pathway FAP 0.72 0.0455 ATG5,KAT6A,FZD6,GTF2H1,BMPR2,SOX9 Adipogenesis pathway Adipogenesis pathway Hyper 0.406 0.0152 BMP4,FGFR2 1.79 0.0758 FOXO1,HDAC8,TNFRSF1A,SREBF1,KAT6A,SIRT1, SAP130,CEBPB,KAT2A,HDAC5 Adipogenesis pathway Tumor 0.43 0.0303 SREBF1,ERCC3,HDAC1,CTNNB1 Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes FAP 0.698 0.0506 CALM1 (includes others),sos1,map2k1,ppp3ca Hyper 0.288 0.038 TGFBR1,MAPK1,NFKB2 Tumor 1.43 0.0633 SMAD2,NFKBIA,JUN,MAPK1,SOS2 Telomerase FAP 0.679 0.0463 PIK3C2B,ELF3,SOS1,TEP1,MAP2K1 Telomerase 0.518 0.0185 ELF4,FGFR2

Telomerase Hyper 1.1 0.0648 ETS1,MAPK1,HDAC8,TEP1,PIK3R2,POT1,HDAC5 Telomerase Tumor 1.39 0.0556 AKT2,MAPK1,PIK3C2A,PIK3C3,HDAC1,SOS2 Erythropoietin FAP 0.672 0.0494 PIK3C2B,SOS1,MAP2K1,PRKD3 Erythropoietin Erythropoietin Hyper 0.247 0.0123 FGFR2 1.22 0.0741 STAT5A,MAPK1,PRKCD,PRKCH,PIK3R2,NFKB2 Erythropoietin Tumor 2.55 0.0864 AKT2,NFKBIA,JUN,MAPK1,PIK3C2A,PIK3C3,SOS2 Insulin Receptor FAP 0.671 0.0438 PIK3C2B,PDE3B,SOS1,NCK1,MAP2K1,EIF4E Insulin Receptor Hyper 0.711 0.0511 TSC1,RAPGEF1,RHOQ,FOXO1,MAPK1,TSC2,PIK3 R2 Insulin Receptor Tumor 3.42 0.0803 AKT2,MTOR,MAPK1,PIK3C2A,PIK3C3,PTPN1,SOS 2,RPS6KB2,STX4,PTPRF,PTEN Tight Junction FAP 0.67 0.0422 CPSF6,EPB41,TJP1,AFDN,MYLK,GOSR1,CSTF3 Tight Junction Hyper 1.9 0.0723 EPB41,MYH9,TGFBR1,TNFRSF1A,NECTIN3,MARK 2,NAPG,CPSF1,CASK,NFKB2,PATJ,NECTIN2 Tight Junction Tumor 1.79 0.0542 AKT2,JUN,NECTIN3,CDK4,SYMPK,STX4,CTNNB1, VASP,PTEN

Hereditary Breast Cancer FAP 0.635 0.0426 PIK3C2B,RFC2,ATR,SMARCD1,SMARCC1,NBN Hereditary Breast Cancer Hereditary Breast Cancer Hyper 0.754 0.0213 PBRM1,FGFR2,CHEK2 2.45 0.0851 HDAC8,FANCD2,SMARCB1,XPC,CREBBP,TUBG1, MSH6,PIK3R2,HLTF,SMARCA4,NBN,HDAC5 Hereditary Breast Cancer Tumor 5.25 0.0993 PBRM1,AKT2,POLR2C,POLR2A,PIK3C2A,PIK3C3, HDAC1,MSH6,CDK4,ARID2,SMARCA4,MLH1,PTEN,RFC3 Epithelial Adherens Junction Epithelial Adherens Junction FAP 0.617 0.042 ACTR2,BAIAP2,AFDN,BMPR2,TCF7L2,CLIP1 Hyper 2.87 0.0909 RAPGEF1,TUBB3,TGFBR1,MYH9,TUBB6,SORBS1, KEAP1,NECTIN3,TUBG1,ACVR1,CLIP1,ACTN1,NE CTIN2 Epithelial Adherens Junction Tumor 3.27 0.0769 AKT2,TUBB3,TUBB4B,NECTIN3,ZYX,CLINT1,CTN NB1,NOTCH1,FARP2,CTNND1,PTEN Molecular Mechanisms of Cancer FAP 0.606 0.0361 CDK12,PIK3C2B,BMPR2,NBN,DAXX,PLCB4,CAMK 2D,CDK8,SOS1,FZD6,ATR,PRKD3,MAP2K1,LRP1 Molecular Mechanisms of Cancer 0.979 0.018 ZBTB17,BMP4,TYK2,FGFR2,ARHGEF1,ARHGEF9, CHEK2

Molecular Mechanisms of Cancer Hyper 3 0.067 RAPGEF1,E2F4,TGFBR1,MAPK1,DVL1,ADCY3,CR EBBP,ADCY6,SMAD6,CDKN2C,NFKB2,RAC3,NBN, PTK2,ARHGEF5,NLK,RHOQ,FANCD2,FOXO1,CDK 11B,PRKCD,PLCB3,PRKCH,PIK3R2,LRP1,BIRC2 Molecular Mechanisms of Cancer Tumor 3.47 0.0541 CDK12,SMAD2,AKT2,TFDP1,MAPK1,PIK3C2A,ARH GEF7,SOS2,DVL1,CDK4,APAF1,ARHGEF1,BRAF,J UN,NFKBIA,PIK3C3,CTNNB1,RASA1,NOTCH1,LRP 1,CTNND1 NF-κB Activation by Viruses FAP 0.601 0.046 PIK3C2B,TBP,ITGA1,PRKD3 NF-κB Activation by Viruses 0.227 0.0115 FGFR2 NF-κB Activation by Viruses Hyper 0.743 0.0575 MAPK1,PRKCD,PRKCH,PIK3R2,NFKB2 NF-κB Activation by Viruses Tumor 1.79 0.069 AKT2,NFKBIA,MAPK1,PIK3C2A,PIK3C3,ITGA1 PEDF FAP 0.601 0.046 ROCK2,ROCK1,PIK3C2B,TCF7L2 PEDF PEDF Hyper 0.227 0.0115 FGFR2 1.52 0.0805 ROCK1,HNF1B,WASF2,MAPK1,PIK3R2,NFKB2,PN PLA2

PEDF Tumor 1.79 0.069 ROCK1,AKT2,NFKBIA,MAPK1,PIK3C2A,PIK3C3 PDGF FAP 0.569 0.0444 PIK3C2B,SOS1,STAT3,MAP2K1 PDGF 1.19 0.0333 TYK2,FGFR2,STAT3 PDGF Tumor 1.73 0.0667 JUN,MAPK1,PIK3C2A,PIK3C3,SOS2,RASA1 NGF FAP 0.561 0.0417 ROCK2,ROCK1,PIK3C2B,SOS1,MAP2K1 NGF NGF Hyper 0.458 0.0167 FGFR2,SMPD1 1.25 0.0667 ROCK1,MAP3K11,MAPK1,PRKCD,CREBBP,TRIO, PIK3R2,NFKB2 NGF Tumor 2.14 0.0667 ROCK1,AKT2,MAPK1,PIK3C2A,PIK3C3,SOS2,RPS 6KB2,TRIO Renin-Angiotensin FAP 0.552 0.0413 PIK3C2B,SOS1,STAT3,MAP2K1,PRKD3 Renin-Angiotensin Renin-Angiotensin Hyper 0.453 0.0165 FGFR2,STAT3 1.62 0.0744 PTK2,MAPK1,ITPR2,PRKCD,ADCY3,ADCY6,PRKC H,PIK3R2,NFKB2 Renin-Angiotensin Tumor 1.19 0.0496 JUN,MAPK1,PIK3C2A,PIK3C3,ITPR3,SOS2 Glucocorticoid Receptor FAP 0.552 0.0357 PIK3C2B,SOS1,PRKAA1,TBP,GTF2H1,GTF2E2,NC OR1,SMARCD1,SMARCC1,STAT3,MAP2K1,PPP3C A

Glucocorticoid Receptor Hyper 0.731 0.0446 STAT5A,TGFBR1,PRKAB2,MAPK1,CREBBP,GTF2 E2,CEBPB,SMARCA4,MED14,SMARCB1,NCOA1,N R3C2,NCOR2,PIK3R2,HLTF Glucocorticoid Receptor Tumor 2.61 0.0506 PBRM1,SMAD2,AKT2,MAPK1,PIK3C2A,SOS2,ARID 2,PCK1,SMARCA4,JUN,POLR2A,POLR2C,NFKBIA, ERCC3,PIK3C3,NCOR1,TAF2 Endometrial Cancer FAP 0.54 0.0469 PIK3C2B,SOS1,MAP2K1 Endometrial Cancer 0.316 0.0156 FGFR2 Endometrial Cancer Hyper 0.421 0.0469 MAPK1,ERBB2,PIK3R2 Endometrial Cancer Tumor 4.78 0.141 AKT2,MAPK1,PIK3C2A,PIK3C3,SOS2,ILK,CTNNB1, MLH1,PTEN IL-2 FAP 0.54 0.0469 PIK3C2B,SOS1,MAP2K1 IL-2 0.316 0.0156 FGFR2 IL-2 Hyper 0.421 0.0469 STAT5A,MAPK1,PIK3R2 IL-2 Tumor 2.43 0.0938 AKT2,JUN,MAPK1,PIK3C2A,PIK3C3,SOS2 Salvage Pathways of Pyrimidine Ribonucleotides Salvage Pathways of Pyrimidine Ribonucleotides FAP 0.529 0.0426 CDK8,PRKAA1,CSNK1A1,MAP2K1 Hyper 1.8 0.0851 PRKX,DMPK,MAPK1,PRKCD,GRK6,PRKCH,UCKL1,PKN1

Salvage Pathways of Tumor 2.19 0.0745 BRAF,AKT2,DMPK,MAPK1,CDK4,PCK1,NEK2 Pyrimidine Ribonucleotides Mevalonate Pathway I FAP 0.523 0.0833 ACAT2 Mevalonate Pathway I Tumor 1.51 0.167 PMVK,HMGCR Endothelin-1 FAP 0.519 0.0376 PNPLA8,PIK3C2B,PLCB4,ABHD3,PDIA3,SOS1,PR KD3 Endothelin-1 Endothelin-1 Hyper 0.527 0.0161 PLCD3,FGFR2,PLD1 0.958 0.0538 PLCD3,MAPK1,ITPR2,CASP2,PRKCD,ADCY3,ADC Y6,PLCB3,PRKCH,PIK3R2 Endothelin-1 Tumor 1.91 0.0538 PLBD1,BRAF,PLD3,JUN,MAPK1,PIK3C2A,PIK3C3,I TPR3,PLCH1,CASP5 Regulation of the Epithelial- Mesenchymal Transition Pathway Regulation of the Epithelial- Mesenchymal Transition Pathway Regulation of the Epithelial- Mesenchymal Transition Pathway Regulation of the Epithelial- Mesenchymal Transition Pathway FAP 0.512 0.0374 PIK3C2B,ESRP2,SOS1,FZD6,STAT3,MAP2K1,TCF 7L2 Hyper 0.523 0.016 TYK2,FGFR2,STAT3 0.704 0.0481 ETS1,MAML1,ADAM17,TGFBR1,MAPK1,DVL1,DVL 3,PIK3R2,NFKB2 Tumor 1.9 0.0535 BRAF,SMAD2,AKT2,MAPK1,PIK3C2A,PIK3C3,DVL 1,SOS2,CTNNB1,NOTCH1 B Cell Receptor FAP 0.505 0.0372 BTK,PIK3C2B,CALM1 (includes others),camk2d,sos1,map2k1,ppp3ca

B Cell Receptor Hyper 0.492 0.0426 PTK2,ETS1,MAP3K11,FOXO1,MAPK1,CREBBP,PI K3R2,NFKB2 B Cell Receptor Tumor 1.88 0.0532 AKT2,MTOR,NFKBIA,JUN,MAPK1,PIK3C2A,PIK3C3,SOS2,RPS6KB2,PTEN CD28 in T Helper Cells FAP 0.502 0.0394 PIK3C2B,CALM1 (includes others),actr2,map2k1,ppp3ca CD28 in T Helper Cells Tumor 1.53 0.0551 AKT2,NFKBIA,JUN,PIK3C2A,HLA-A,PIK3C3,ITPR3 Cholesterol Biosynthesis I FAP 0.494 0.0769 DHCR7 Cholesterol Biosynthesis I Hyper 0.436 0.0769 LBR Cholesterol Biosynthesis I Tumor 1.45 0.154 HSD17B7,LBR Cholesterol Biosynthesis II FAP 0.494 0.0769 DHCR7 (via 24,25-dihydrolanosterol) Cholesterol Biosynthesis II Hyper 0.436 0.0769 LBR (via 24,25-dihydrolanosterol) Cholesterol Biosynthesis II Tumor 1.45 0.154 HSD17B7,LBR (via 24,25-dihydrolanosterol) Cholesterol Biosynthesis III FAP 0.494 0.0769 DHCR7 (via Desmosterol) Cholesterol Biosynthesis III Hyper 0.436 0.0769 LBR (via Desmosterol) Cholesterol Biosynthesis III Tumor 1.45 0.154 HSD17B7,LBR (via Desmosterol) IL-6 FAP 0.494 0.0391 IL6ST,PIK3C2B,SOS1,STAT3,MAP2K1 IL-6 IL-6 Hyper 0.422 0.0156 FGFR2,STAT3 0.345 0.0391 MAPK1,TNFRSF1A,CEBPB,PIK3R2,NFKB2

IL-6 Tumor 1.51 0.0547 AKT2,NFKBIA,JUN,MAPK1,PIK3C2A,PIK3C3,SOS2 Actin Cytoskeleton FAP 0.494 0.0362 ROCK2,ROCK1,PIK3C2B,ACTR2,SOS1,BAIAP2,MY LK,MAP2K1 Actin Cytoskeleton Actin Cytoskeleton Hyper 0.403 0.0136 DIAPH2,FGFR2,ARHGEF1 1.09 0.0543 PTK2,ROCK1,DIAPH1,MYH9,CYFIP2,WASF2,MAP K1,TRIO,PIK3R2,GIT1,RAC3,ACTN1 Actin Cytoskeleton Tumor 2.23 0.0543 ROCK1,MAPK1,PIK3C2A,PIK3C3,DIAPH3,ARHGEF 7,SOS2,PIKFYVE,TRIO,ARHGEF1,TLN1,NCKAP1 FAK FAP 0.492 0.0408 PIK3C2B,HMMR,SOS1,MAP2K1 FAK Tumor 2.68 0.0816 AKT2,MAPK1,PIK3C2A,PIK3C3,ARHGEF7,SOS2,T LN1,PTEN Dopamine-DARPP32 Feedback in camp FAP 0.485 0.0375 CALM1 (includes others),plcb4,pdia3,csnk1a1,prkd3,ppp3ca Dopamine-DARPP32 Feedback in camp Hyper 2.02 0.075 CSNK1E,PLCD3,CSNK1G2,ITPR2,CSNK1G3,PRKC D,CREBBP,ADCY3,ADCY6,PLCB3,ATP2A3,PRKCH 14-3-3-mediated FAP 0.479 0.0385 PIK3C2B,PLCB4,PDIA3,MAP2K1,PRKD3 14-3-3-mediated 0.414 0.0154 PLCD3,FGFR2

14-3-3-mediated Hyper 3.25 0.1 TSC1,TUBB3,MAPK1,TNFRSF1A,TUBG1,PLCD3,F OXO1,TUBB6,PRKCD,TSC2,PLCB3,PRKCH,PIK3R 2 14-3-3-mediated Tumor 1.95 0.0615 AKT2,TUBB3,JUN,MAPK1,PIK3C2A,TUBB4B,PIK3C 3,PLCH1 Glioblastoma Multiforme Glioblastoma Multiforme Glioblastoma Multiforme FAP 0.479 0.0373 PIK3C2B,PLCB4,PDIA3,SOS1,FZD6,MAP2K1 Hyper 0.307 0.0124 PLCD3,FGFR2 1.62 0.0683 PLCD3,TSC1,E2F4,RHOQ,FOXO1,MAPK1,ITPR2,P RKCD,TSC2,PLCB3,PIK3R2 Glioblastoma Multiforme Tumor 2.84 0.0683 AKT2,MTOR,MAPK1,PIK3C2A,PIK3C3,ITPR3,SOS2,CDK4,CTNNB1,PLCH1,PTEN RANK in Osteoclasts FAP 0.474 0.04 PIK3C2B,CALM1 (includes others),map2k1,ppp3ca RANK in Osteoclasts RANK in Osteoclasts DNA Double-Strand Break Repair by Homologous Recombination DNA Double-Strand Break Repair by Homologous Recombination Hyper 0.582 0.05 MAP3K11,MAPK1,PIK3R2,NFKB2,BIRC2 Tumor 1.53 0.06 AKT2,NFKBIA,JUN,MAPK1,PIK3C2A,PIK3C3 FAP 0.468 0.0714 NBN Hyper 1.95 0.214 LIG1,ATRX,NBN DNA Double-Strand Break FAP 0.468 0.0714 NBN

Repair by Non-Homologous End Joining DNA Double-Strand Break Repair by Non-Homologous End Joining DNA Double-Strand Break Repair by Non-Homologous End Joining Hyper 0.411 0.0714 NBN Tumor 1.39 0.143 XRCC6,LIG3 CXCR4 FAP 0.459 0.0366 ROCK2,ROCK1,PIK3C2B,PLCB4,MAP2K1,PRKD3 CXCR4 Hyper 1.57 0.0671 PTK2,ROCK1,RHOQ,MAPK1,ITPR2,PRKCD,ADCY 3,ADCY6,PLCB3,PRKCH,PIK3R2 CXCR4 Tumor 1.41 0.0488 ROCK1,AKT2,JUN,MAPK1,PIK3C2A,PIK3C3,RACK 1,ITPR3 P2Y Purigenic Receptor Pathway P2Y Purigenic Receptor Pathway P2Y Purigenic Receptor Pathway FAP 0.457 0.0376 PIK3C2B,PLCB4,PDIA3,MAP2K1,PRKD3 Hyper 0.402 0.015 PLCD3,FGFR2 1.77 0.0752 PLCD3,MAPK1,PRKCD,CREBBP,ADCY3,ADCY6,P LCB3,PRKCH,PIK3R2,NFKB2 P2Y Purigenic Receptor Pathway Tumor 1.44 0.0526 AKT2,JUN,MAPK1,PIK3C2A,PIK3C3,RACK1,PLCH1 Superpathway of Inositol Phosphate Compounds FAP 0.455 0.0351 PPFIA1,PIK3C2B,PLCB4,PPP1R12C,DUSP11,PPP 4R1,PPP3CA,SACM1L Superpathway of Inositol Phosphate Compounds 1.07 0.0219 PLCD3,IPMK,PTPN2,DUSP11,FGFR2

Superpathway of Inositol Phosphate Compounds Hyper 0.782 0.0482 MTMR6,PLCD3,PTPN23,SGPP2,PLCB3,PPM1F,ER BB2,PPP4R1,PIK3R2,PI4KA,DUSP16 Superpathway of Inositol Phosphate Compounds Tumor 1.38 0.0439 PIK3C2A,PIK3C3,PTPN1,PIKFYVE,RASA1,PMPCA, PLCH1,PTPRF,PPIP5K2,PTEN Androgen FAP 0.436 0.0368 CALM1 (includes others),tbp,gtf2h1,gtf2e2,prkd3 Androgen Hyper 1.01 0.0588 CALR,MAPK1,PRKCD,CREBBP,NCOA1,GTF2E2,P RKCH,NFKB2 Androgen Tumor 1.39 0.0515 POLR2C,POLR2A,JUN,MAPK1,ERCC3,RACK1,TAF 2 STAT3 Pathway FAP 0.434 0.0405 BMPR2,STAT3,MAP2K1 STAT3 Pathway STAT3 Pathway Chronic Myeloid Leukemia Chronic Myeloid Leukemia 2.15 0.0541 PTPN2,TYK2,FGFR2,STAT3 Hyper 0.327 0.0405 TGFBR1,MAP3K11,MAPK1 FAP 0.433 0.0381 PIK3C2B,SOS1,CBLC,MAP2K1 Hyper 1.54 0.0762 STAT5A,E2F4,TGFBR1,MAPK1,HDAC8,PIK3R2,NF KB2,HDAC5 Chronic Myeloid Leukemia Tumor 3.1 0.0857 AKT2,RBL2,TFDP1,MAPK1,PIK3C2A,PIK3C3,HDAC 1,SOS2,CDK4 UVA-Induced MAPK FAP 0.433 0.0381 PIK3C2B,PLCB4,PDIA3,PARP14 UVA-Induced MAPK 1.64 0.0381 PLCD3,FGFR2,SMPD1,PARP9

UVA-Induced MAPK Hyper 0.309 0.0381 PLCD3,MAPK1,PLCB3,PIK3R2 UVA-Induced MAPK Tumor 2.49 0.0762 MTOR,JUN,MAPK1,PIK3C2A,PIK3C3,RPS6KB2,PL CH1,PARP14 IGF-1 FAP 0.425 0.0377 PIK3C2B,SOS1,STAT3,MAP2K1 IGF-1 0.529 0.0189 FGFR2,STAT3 IGF-1 Hyper 0.302 0.0377 PTK2,FOXO1,MAPK1,PIK3R2 IGF-1 Tumor 2.47 0.0755 AKT2,JUN,MAPK1,PIK3C2A,PIK3C3,SOS2,RPS6K B2,RASA1 Mismatch Repair in FAP 0.422 0.0625 RFC2 Eukaryotes Mismatch Repair in Hyper 0.985 0.125 MSH6,POLD1 Eukaryotes Mismatch Repair in Tumor 2.25 0.188 MSH6,MLH1,RFC3 Eukaryotes IL-9 FAP 0.419 0.0444 PIK3C2B,STAT3 IL-9 1.11 0.0444 FGFR2,STAT3 IL-9 Hyper 0.695 0.0667 STAT5A,PIK3R2,NFKB2 IL-9 Tumor 0.548 0.0444 PIK3C2A,PIK3C3 Phospholipase C FAP 0.418 0.034 BTK,MARCKS,CALM1 (includes others),plcb4,sos1,map2k1,prkd3,ppp3ca Phospholipase C 0.655 0.017 PLCD3,ARHGEF1,ARHGEF9,PLD1

Phospholipase C Hyper 1.47 0.0596 HDAC8,MAPK1,ITPR2,CREBBP,ADCY3,ADCY6,NF KB2,HDAC5,PLCD3,ARHGEF5,RHOQ,PRKCD,PLC B3,PRKCH Phospholipase C Tumor 0.732 0.034 PLD3,MAPK1,ARHGEF7,HDAC1,RACK1,ITPR3,SO S2,ARHGEF1 IL-15 FAP 0.415 0.0395 PIK3C2B,STAT3,MAP2K1 IL-15 1.36 0.0395 TYK2,FGFR2,STAT3 IL-15 Hyper 1.33 0.0789 PTK2,STAT5A,MAPK1,PIK3R2,NFKB2,RAC3 IL-15 Tumor 1.49 0.0658 STAT6,AKT2,MAPK1,PIK3C2A,PIK3C3 Angiopoietin FAP 0.406 0.039 PIK3C2B,SOS1,NCK1 Angiopoietin 0.261 0.013 FGFR2 Angiopoietin Hyper 0.899 0.0649 PTK2,STAT5A,FOXO1,PIK3R2,NFKB2 Angiopoietin Tumor 1.47 0.0649 AKT2,NFKBIA,PIK3C2A,PIK3C3,RASA1 Neurotrophin/TRK FAP 0.406 0.039 PIK3C2B,SOS1,MAP2K1 Neurotrophin/TRK 0.261 0.013 FGFR2 Neurotrophin/TRK Hyper 0.303 0.039 MAPK1,CREBBP,PIK3R2 Neurotrophin/TRK Tumor 1.47 0.0649 JUN,MAPK1,PIK3C2A,PIK3C3,SOS2

CD40 FAP 0.398 0.0385 PIK3C2B,STAT3,MAP2K1 CD40 0.721 0.0256 FGFR2,STAT3 CD40 Hyper 0.295 0.0385 MAPK1,PIK3R2,NFKB2 CD40 Tumor 1.45 0.0641 NFKBIA,JUN,MAPK1,PIK3C2A,PIK3C3 IL-17A in Airway Cells IL-17A in Airway Cells IL-17A in Airway Cells IL-17A in Airway Cells FAP 0.398 0.0385 PIK3C2B,STAT3,MAP2K1 1.34 0.0385 TYK2,FGFR2,STAT3 Hyper 0.295 0.0385 MAPK1,PIK3R2,NFKB2 Tumor 2.64 0.0897 AKT2,NFKBIA,MAPK1,PIK3C2A,PIK3C3,MUC5B,PT EN Paxillin FAP 0.395 0.0364 PIK3C2B,SOS1,ITGA1,NCK1 Paxillin Hyper 0.482 0.0455 PTK2,NCK2,MAPK1,PIK3R2,ACTN1 Paxillin Tumor 1.83 0.0636 MAPK1,PIK3C2A,PIK3C3,ARHGEF7,SOS2,TLN1,IT GA1 p53 FAP 0.388 0.036 PIK3C2B,STAG1,TOPBP1,ATR p53 0.976 0.027 TOPBP1,FGFR2,CHEK2 p53 Tumor 3.56 0.0901 AKT2,JUN,PIK3C2A,PIK3C3,HDAC1,CCNK,APAF1, CDK4,CTNNB1,PTEN

Colorectal Cancer Metastasis FAP 0.379 0.0329 IL6ST,PIK3C2B,SOS1,FZD6,STAT3,MAP2K1,TCF7 L2,LRP1 Colorectal Cancer Metastasis Colorectal Cancer Metastasis Hyper 0.622 0.0165 TYK2,FGFR2,TLR3,STAT3 0.868 0.0494 E2F4,RHOQ,TGFBR1,MAPK1,TNFRSF1A,DVL1,AD CY3,ADCY6,MSH6,PIK3R2,NFKB2,LRP1 Colorectal Cancer Metastasis Tumor 2.75 0.0576 SMAD2,AKT2,PIK3C2A,MAPK1,SOS2,RACK1,DVL1,MLH1,BRAF,JUN,PIK3C3,MSH6,CTNNB1,LRP1 Renal Cell Carcinoma Renal Cell Carcinoma Renal Cell Carcinoma Renal Cell Carcinoma Huntington's Disease FAP 0.373 0.037 PIK3C2B,SOS1,MAP2K1 0.696 0.0247 EGLN3,FGFR2 Hyper 0.832 0.0617 ETS1,RAPGEF1,MAPK1,CREBBP,PIK3R2 Tumor 1.93 0.0741 AKT2,JUN,MAPK1,PIK3C2A,PIK3C3,SOS2 FAP 0.361 0.0324 PIK3C2B,PLCB4,SOS1,TBP,PSME4,NCOR1,GOSR 1,PRKD3 Huntington's Disease Hyper 1.92 0.0648 SDHB,HDAC8,MAPK1,G,CREBBP,IFT57,NAPG, HDAC5,DNM1,CASP2,PRKCD,PSME4,PLCB3,PRK CH,NCOR2,PIK3R2

Huntington's Disease Tumor 4.66 0.0729 AKT2,MAPK1,PIK3C2A,HDAC1,SOS2,RACK1,APA F1,MTOR,JUN,POLR2A,POLR2C,PIK3C3,HTT,PSM E4,NCOR1,RASA1,CASP5,DNM2 Rac FAP 0.355 0.0345 PIK3C2B,ACTR2,BAIAP2,MAP2K1 Rac Rac Hyper 0.477 0.0172 FGFR2,PLD1 1.33 0.069 PTK2,MCF2L,CYFIP2,MAP3K11,MAPK1,PIK3R2,NF KB2,PI4KA Rac Tumor 1.26 0.0517 JUN,MAPK1,PIK3C2A,PIK3C3,PIKFYVE,NCKAP1 Sirtuin Pathway FAP 0.35 0.0318 ATG5,POLR1B,ATG4D,PRKAA1,SIRT3,STAT3,NDU FA1,TOMM70,NBN Sirtuin Pathway Sirtuin Pathway Hyper 1.57 0.0247 CPT1A,ATG9A,CPT1B,SIRT6,ZBTB14,G6PD,STAT 3 1.44 0.0565 PPID,SDHB,MAPK1,G,SF3A1,NFKB2,XPA,NBN, NDUFS1,FOXO1,ATG4D,SREBF1,SIRT1,XPC,NDU FS2,KAT2A Sirtuin Pathway Tumor 2.55 0.053 TOMM40,EPAS1,TIMM44,MAPK1,SMARCA5,PCK1, PFKM,HIST1H1B,MTOR,NDUFS1,JUN,SREBF1,ND UFA11,XRCC6,GOT2

icos-icosl in T Helper Cells FAP 0.342 0.0339 PIK3C2B,CALM1 (includes others),camk2d,ppp3ca icos-icosl in T Helper Cells Tumor 1.68 0.0593 AKT2,NFKBIA,PIK3C2A,HLA- A,PIK3C3,ITPR3,PTEN Nur77 in T Lymphocytes Nur77 in T Lymphocytes FAP 0.336 0.0377 CALM1 (includes others),ppp3ca Tumor 1.46 0.0755 HLA-A,HDAC1,APAF1,CABIN1 Neuregulin FAP 0.335 0.0349 SOS1,MAP2K1,PRKD3 Neuregulin Hyper 1.54 0.0814 STAT5A,ADAM17,MAPK1,PRKCD,PRKCH,ERBB2, PIK3R2 Neuregulin Tumor 1.81 0.0698 AKT2,MTOR,MAPK1,SOS2,RPS6KB2,PTEN TGF-β FAP 0.328 0.0345 SOS1,BMPR2,MAP2K1 TGF-β 0.227 0.0115 BMP4 TGF-β Hyper 1.1 0.069 TGFBR1,MAPK1,CREBBP,SKI,ACVR1,SMAD6 TGF-β Tumor 2.37 0.0805 ZFYVE9,SMAD2,JUN,MAPK1,HDAC1,SOS2,SMUR F2 HER-2 in Breast Cancer HER-2 in Breast Cancer HER-2 in Breast Cancer FAP 0.321 0.0341 PIK3C2B,SOS1,PRKD3 Hyper 0.224 0.0114 FGFR2 1.49 0.0795 TSC1,FOXO1,PRKCD,TSC2,PRKCH,ERBB2,PIK3R 2

HER-2 in Breast Tumor 0.823 0.0455 AKT2,PIK3C2A,PIK3C3,SOS2 Cancer Melanoma FAP 0.318 0.0364 PIK3C2B,MAP2K1 Melanoma 0.364 0.0182 FGFR2 Melanoma Hyper 0.244 0.0364 MAPK1,PIK3R2 Melanoma Tumor 3.56 0.127 BRAF,AKT2,MAPK1,PIK3C2A,PIK3C3,CDK4,PTEN Apoptosis FAP 0.314 0.0337 ROCK1,MAP2K1,AIFM1 Apoptosis Hyper 2.45 0.101 ACIN1,ROCK1,MAPK1,TNFRSF1A,CASP2,BIRC6,N FKB2,AIFM1,BIRC2 Apoptosis Tumor 1.75 0.0674 ACIN1,ROCK1,NFKBIA,MAPK1,BIRC6,APAF1 IL-22 FAP 0.293 0.0417 STAT3 IL-22 1.6 0.0833 TYK2,STAT3 IL-22 Hyper 0.7 0.0833 STAT5A,MAPK1 IL-22 Tumor 1.75 0.125 AKT2,MAPK1,IL10RB Role of JAK1, JAK2 and TYK2 FAP 0.293 0.0417 STAT3 in Interferon Role of JAK1, JAK2 and TYK2 2.74 0.125 PTPN2,TYK2,STAT3 in Interferon Role of JAK1, JAK2 and TYK2 Hyper 0.245 0.0417 NFKB2 in Interferon Role of JAK1, JAK2 and TYK2 Tumor 0.364 0.0417 IFNAR2 in Interferon CDP-diacylglycerol FAP 0.293 0.0417 TAZ Biosynthesis I CDP-diacylglycerol 0.659 0.0417 LPCAT4

Biosynthesis I CDP-diacylglycerol Biosynthesis I Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes Hyper 1.32 0.125 TAMM41,LPCAT2,AGPAT3 FAP 0.289 0.0323 ACTR2,NCK1,PRKD3 Hyper 0.21 0.0108 PLD1 0.992 0.0645 NCK2,MAPK1,PRKCD,PRKCH,PIK3R2,RAC3 Tumor 2.21 0.0753 AKT2,PLD3,MAPK1,RPS6KB2,TLN1,VASP,PTEN Prostate Cancer FAP 0.277 0.0316 PIK3C2B,SOS1,MAP2K1 Prostate Cancer 0.204 0.0105 FGFR2 Prostate Cancer Hyper 0.639 0.0526 FOXO1,MAPK1,CREBBP,PIK3R2,NFKB2 Prostate Cancer Tumor 4.13 0.105 AKT2,MTOR,NFKBIA,TFDP1,MAPK1,PIK3C2A,PIK3 C3,SOS2,CTNNB1,PTEN Phosphatidylglycerol Biosynthesis II (Non-plastidic) Phosphatidylglycerol Biosynthesis II (Non-plastidic) Phosphatidylglycerol Biosynthesis II (Non-plastidic) Virus Entry via Endocytic Pathways Virus Entry via Endocytic Pathways FAP 0.269 0.0385 TAZ 0.629 0.0385 LPCAT4 Hyper 1.23 0.115 TAMM41,LPCAT2,AGPAT3 FAP 0.239 0.0294 PIK3C2B,ITGA1,PRKD3 0.552 0.0196 FGFR2,AP1B1

Virus Entry via Endocytic Pathways Virus Entry via Endocytic Pathways Hyper 0.853 0.0588 DNM1,FLNB,PRKCD,PRKCH,PIK3R2,RAC3 Tumor 2.57 0.0784 FLNB,AP1G2,PIK3C2A,HLA- A,PIK3C3,AP2B1,ITGA1,DNM2 Remodeling of Epithelial Adherens Junctions Remodeling of Epithelial Adherens Junctions Remodeling of Epithelial Adherens Junctions Remodeling of Epithelial Adherens Junctions 4-1BB in T Lymphocytes 4-1BB in T Lymphocytes 4-1BB in T Lymphocytes Inhibition of Angiogenesis by TSP1 Inhibition of Angiogenesis by TSP1 Inhibition of Angiogenesis by TSP1 Role of JAK2 in Hormone-like Cytokine Role of JAK2 in Hormone-like Cytokine Role of JAK2 in Hormone-like Cytokine Role of JAK2 in Hormone-like Cytokine FAP 0.237 0.0303 ACTR2,CLIP1 Hyper 0.307 0.0152 MAPRE3 2.13 0.106 DNM1,TUBB3,TUBB6,TUBG1,HGS,ACTN1,CLIP1 Tumor 2.36 0.0909 TUBB3,TUBB4B,ZYX,CTNNB1,DNM2,CTNND1 FAP 0.212 0.0312 MAP2K1 Hyper 0.519 0.0625 MAPK1,NFKB2 Tumor 1.42 0.0938 NFKBIA,JUN,MAPK1 FAP 0.212 0.0312 CD47 Hyper 1.01 0.0938 HSPG2,TGFBR1,MAPK1 Tumor 1.42 0.0938 AKT2,JUN,MAPK1 FAP 0.212 0.0312 STAT3 1.37 0.0625 TYK2,STAT3 Hyper 0.519 0.0625 STAT5A,HLTF Tumor 0.275 0.0312 PTPN1

Aryl Hydrocarbon Receptor Hyper 0.722 0.0515 NCOA7,MAPK1,DHFR,NFKB2,NCOR2,RXRB,SMA RCA4 Aryl Hydrocarbon Receptor Tumor 2.87 0.0735 TRIP11,RBL2,JUN,TFDP1,MAPK1,APAF1,CDK4,AL DH18A1,SMARCA4,MCM7 LXR/RXR Activation Hyper 1.62 0.0744 SCD,TNFRSF1A,SREBF1,FASN,ABCG1,IRF3,NFK B2,NCOR2,RXRB LXR/RXR Activation Tumor 0.505 0.0331 SREBF1,FASN,NCOR1,HMGCR VDR/RXR Activation VDR/RXR Activation Hyper 0.261 0.013 KLF4 3.52 0.13 FOXO1,PRKCD,NCOA1,PRKCH,CEBPB,NCOR2,H R,RXRB,KLF4,PSMC5 Caveolar-mediated Endocytosis IL-8 Tumor 1.6 0.0704 FLNB,HLA-A,PTPN1,ITGA1,DNM2 Hyper 0.439 0.0408 PTK2,ROCK1,RHOQ,MAPK1,PRKCD,PRKCH,PIK3 R2,RAC3 IL-8 Tumor 2.65 0.0612 ROCK1,BRAF,AKT2,ARRB2,MTOR,PLD3,JUN,MAP K1,PIK3C2A,PIK3C3,RACK1,VASP Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses Hyper 0.82 0.0229 OAS2,FGFR2,TLR3 1.08 0.0611 MAPK1,TICAM1,PRKCD,PRKCH,IRF3,PIK3R2,NFK B2,OAS3 Tumor 0.437 0.0305 MAPK1,PIK3C2A,PIK3C3,C1QA

TREM1 0.793 0.0286 TLR3,STAT3 TREM1 Hyper 1.03 0.0714 SIGIRR,STAT5A,NLRC5,MAPK1,NFKB2 TREM1 Tumor 0.65 0.0429 AKT2,MAPK1,CASP5 Lymphotoxin β Receptor Lymphotoxin β Receptor Lymphotoxin β Receptor 0.302 0.0149 FGFR2 Hyper 1.09 0.0746 MAPK1,CREBBP,PIK3R2,NFKB2,BIRC2 Tumor 2.33 0.0896 AKT2,NFKBIA,MAPK1,PIK3C2A,PIK3C3,APAF1 IL-17 0.234 0.0118 FGFR2 IL-17 Hyper 0.248 0.0353 MAPK1,CEBPB,PIK3R2 IL-17 Tumor 1.84 0.0706 AKT2,JUN,MAPK1,PIK3C2A,PIK3C3,MUC5B CTLA4 in Cytotoxic T Lymphocytes CTLA4 in Cytotoxic T Lymphocytes Reelin in Neurons Reelin in Neurons 0.576 0.0204 FGFR2,AP1B1 Tumor 1.56 0.0612 AKT2,AP1G2,PIK3C2A,HLA-A,PIK3C3,AP2B1 Hyper 1.16 0.0326 FGFR2,ARHGEF1,ARHGEF9 0.676 0.0543 ARHGEF5,MAP3K11,PIK3R2,MAPK8IP3,FRK Reelin in Neurons Tumor 0.775 0.0435 PIK3C2A,PIK3C3,ARHGEF1,ITGA1 Relaxin Tumor 1.99 0.0584 BRAF,AKT2,NFKBIA,JUN,MAPK1,PIK3C2A,PIK3C3, RACK1,NPR2

Agrin Interactions at Neuromuscular Junction Agrin Interactions at Neuromuscular Junction Docosahexaenoic Acid (DHA) Docosahexaenoic Acid (DHA) Docosahexaenoic Acid (DHA) Antiproliferative Role of Somatostatin Receptor 2 Antiproliferative Role of Somatostatin Receptor 2 Hyper 1.56 0.0896 PTK2,MAPK1,DVL1,ERBB2,AGRN,RAC3 Tumor 1.7 0.0746 JUN,MAPK1,ARHGEF7,DVL1,ITGA1 0.382 0.0192 FGFR2 Hyper 0.575 0.0577 FOXO1,PIK3R2,PNPLA2 Tumor 1.48 0.0769 AKT2,PIK3C2A,PIK3C3,APAF1 0.276 0.0137 FGFR2 Tumor 2.15 0.0822 BRAF,MAPK1,PIK3C2A,PIK3C3,RACK1,NPR2 Germ Cell-Sertoli Cell Junction Germ Cell-Sertoli Cell Junction Hyper 0.285 0.0118 KEAP1,FGFR2 3.6 0.0947 TUBB3,TGFBR1,MAP3K11,MAPK1,TNFRSF1A,TUB G1,NECTIN3,RAC3,PTK2,RHOQ,TUBB6,SORBS1, KEAP1,PIK3R2,ACTN1,NECTIN2 Germ Cell-Sertoli Cell Junction Tumor 2.67 0.0651 TUBB3,MAPK1,PIK3C2A,TUBB4B,PIK3C3,NECTIN 3,ILK,ZYX,CLINT1,CTNNB1,CTNND1 Small Cell Lung Cancer Small Cell Lung Cancer Hyper 0.665 0.0235 FGFR2,SKP2 0.771 0.0588 PTK2,PIK3R2,NFKB2,RXRB,BIRC2

Small Cell Lung Cancer Tumor 3.79 0.106 AKT2,NFKBIA,TFDP1,PIK3C2A,PIK3C3,APAF1,CD K4,SKP2,PTEN Type II Diabetes Mellitus Type II Diabetes Mellitus Hyper 0.335 0.0132 FGFR2,SMPD1 1.1 0.0592 PRKAB2,MAPK1,TNFRSF1A,PRKCD,PRKCH,CEBP B,PIK3R2,NFKB2,NSMAF Type II Diabetes Mellitus Tumor 1.58 0.0526 AKT2,ACSL3,MTOR,NFKBIA,MAPK1,PIK3C2A,PIK3 C3,ADIPOR1 Myc Mediated Apoptosis Myc Mediated Apoptosis Pancreatic Adenocarcinoma Pancreatic Adenocarcinoma Pancreatic Adenocarcinoma 0.289 0.0143 FGFR2 Tumor 1.62 0.0714 AKT2,PIK3C2A,PIK3C3,SOS2,APAF1 1.46 0.0333 TYK2,FGFR2,STAT3,PLD1 Hyper 0.632 0.05 E2F4,TGFBR1,MAPK1,ERBB2,PIK3R2,NFKB2 Tumor 2.69 0.075 SMAD2,AKT2,PLD3,TFDP1,MAPK1,PIK3C2A,PIK3 C3,CDK4,NOTCH1 Sphingosine-1-phosphate Sphingosine-1-phosphate Hyper 0.871 0.0242 PLCD3,FGFR2,SMPD1 1.56 0.0726 PTK2,PLCD3,RHOQ,MAPK1,CASP2,ADCY3,ADCY 6,PLCB3,PIK3R2 Sphingosine-1-phosphate Tumor 1.15 0.0484 AKT2,MAPK1,PIK3C2A,PIK3C3,PLCH1,CASP5

Systemic Lupus Erythematosus Tumor 1.88 0.0507 AKT2,MTOR,JUN,MAPK1,PIK3C2A,HLA- A,PIK3C3,PRPF8,SOS2,SNRNP200,SNRNP40 ILK Hyper 1.15 0.057 PTK2,NCK2,FLNB,MYH9,RHOQ,MAPK1,TNFRSF1 A,CREBBP,PIK3R2,NFKB2,ACTN1 ILK Tumor 2.24 0.057 PARVB,FLNB,AKT2,MTOR,JUN,MAPK1,PIK3C2A,P IK3C3,ILK,CTNNB1,PTEN AMPK AMPK Hyper 0.746 0.0186 PBRM1,CPT1A,CPT1B,FGFR2 1.45 0.0605 TSC1,PRKAB2,MAPK1,CREBBP,MT8,SMARCA4,FOXO1,FASN,SMARCB1,TSC2,SIRT1,PIK3R2,HLT F AMPK Tumor 2.32 0.0558 PBRM1,AKT2,MTOR,MAPK1,PIK3C2A,EEF2,PIK3C 3,FASN,ARID2,HMGCR,SMARCA4,PFKM Ovarian Cancer Tumor 5.17 0.0979 AKT2,TFDP1,PIK3C2A,MAPK1,DVL1,CDK4,MLH1,P TEN,BRAF,MTOR,PIK3C3,RPS6KB2,MSH6,CTNNB 1 Estrogen-Dependent Breast Cancer Estrogen-Dependent Breast Cancer Hyper 0.254 0.0127 FGFR2 0.865 0.0633 STAT5A,MAPK1,CREBBP,PIK3R2,NFKB2

Estrogen-Dependent Breast Cancer Role of PI3K/AKT in the Pathogenesis of Influenza Role of PI3K/AKT in the Pathogenesis of Influenza Role of PI3K/AKT in the Pathogenesis of Influenza Role of Tissue Factor in Cancer Sertoli Cell-Sertoli Cell Junction Sertoli Cell-Sertoli Cell Junction Tumor 1.98 0.0759 AKT2,JUN,MAPK1,PIK3C2A,PIK3C3,HSD17B7 0.265 0.0132 FGFR2 Hyper 0.575 0.0526 MAPK1,IRF3,PIK3R2,NFKB2 Tumor 2.06 0.0789 AKT2,NFKBIA,MAPK1,PIK3C2A,PIK3C3,MLH1 Tumor 1.65 0.0583 AKT2,ARRB2,MTOR,MAPK1,PIK3C2A,PIK3C3,PTE N 0.275 0.0116 DLG1,KEAP1 Hyper 1.77 0.0694 EPB41,TUBB3,MAP3K11,MAPK1,TUBB6,SORBS1, TNFRSF1A,KEAP1,NECTIN3,TUBG1,ACTN1,NECT IN2 Sertoli Cell-Sertoli Cell Junction Tumor 2.6 0.0636 AKT2,TUBB3,JUN,MAPK1,TUBB4B,NECTIN3,ILK,S YMPK,CLINT1,CTNNB1,PTEN inos 0.438 0.0227 TYK2 inos Hyper 0.715 0.0682 MAPK1,CREBBP,NFKB2 inos Tumor 1.72 0.0909 NFKBIA,JUN,MAPK1,IRF1 Cell Cycle: G1/S Checkpoint Regulation Cell Cycle: G1/S Checkpoint Regulation Hyper 0.311 0.0154 SKP2 1.14 0.0769 E2F4,FOXO1,HDAC8,CDKN2C,HDAC5

Cell Cycle: G1/S Checkpoint Regulation Nucleotide Excision Repair Pathway Nucleotide Excision Repair Pathway PI3K/AKT Tumor 1.75 0.0769 RBL2,TFDP1,HDAC1,CDK4,SKP2 Hyper 0.467 0.0571 XPC,XPA Tumor 1.32 0.0857 POLR2C,POLR2A,ERCC3 Hyper 0.878 0.0569 TSC1,FOXO1,MAPK1,TSC2,PIK3R2,NFKB2,THEM4 PI3K/AKT Tumor 2.62 0.0732 AKT2,MTOR,NFKBIA,MAPK1,SOS2,ILK,RPS6KB2, CTNNB1,PTEN IL-4 0.657 0.0233 TYK2,FGFR2 IL-4 Tumor 3.05 0.093 STAT6,AKT2,MTOR,PIK3C2A,HLA- A,PIK3C3,SOS2,RPS6KB2 Phagosome Maturation Phagosome Maturation Hyper 0.383 0.0145 ATP6V0A2,ATP6V0D1 1.67 0.0725 CALR,TUBB3,TUBB6,TUBE1,CTSO,VPS33A,TUBG 1,NAPG,VPS37C,CTSF Phagosome Maturation Tumor 2.29 0.0652 DYNC1H1,CTSA,TUBB3,TUBB4B,HLA- A,PIK3C3,ATP6V0D1,PIKFYVE,ATP6V0A1 Cancer Drug Resistance By Drug Efflux Cancer Drug Resistance By Drug Efflux Cancer Drug Resistance By Drug Efflux 0.402 0.0204 ABCG2 Hyper 0.623 0.0612 FOXO1,MAPK1,PIK3R2 Tumor 1.57 0.0816 BRAF,AKT2,MAPK1,PTEN

IL-7 Pathway 0.23 0.0116 FGFR2 IL-7 Pathway Hyper 0.757 0.0581 PTK2,STAT5A,FOXO1,MAPK1,PIK3R2 IL-7 Pathway Tumor 1.81 0.0698 AKT2,JUN,MAPK1,PIK3C2A,PIK3C3,SOS2 Opioid Pathway Hyper 0.924 0.0506 CAMK1,MAPK1,ITPR2,PRKCD,CREBBP,ADCY3,G RK6,ADCY6,PRKCH,NFKB2,FRK,RAC3 Opioid Pathway Tumor 1.62 0.0464 BRAF,AKT2,ARRB2,NFKBIA,AP1G2,MAPK1,AP2B1,ITPR3,SOS2,RPS6KB2,CTNNB1 IL-15 Production 1.48 0.0714 TYK2,MST1R IL-15 Production Hyper 2.61 0.179 PTK2,MAP3K11,IRF3,NFKB2,FRK IL-15 Production Tumor 0.315 0.0357 IRF1 Antiproliferative Role of TOB in T Cell Antiproliferative Role of TOB in T Cell Antiproliferative Role of TOB in T Cell IL-17A in Fibroblasts IL-17A in Fibroblasts Estrogen-mediated S-phase Entry 0.629 0.0385 SKP2 Hyper 1.23 0.115 TGFBR1,MAPK1,PABPC4 Tumor 1.66 0.115 SMAD2,MAPK1,SKP2 Hyper 0.926 0.0857 MAPK1,CEBPB,NFKB2 Tumor 1.32 0.0857 NFKBIA,JUN,MAPK1 Hyper 0.629 0.0385 SKP2 Estrogen-mediated S-phase 0.223 0.0385 E2F4 Entry Estrogen-mediated S-phase Tumor 1.66 0.115 TFDP1,CDK4,SKP2

Entry Thio-molybdenum Cofactor Tumor 1.63 1 MOCOS Biosynthesis 2-ketoglutarate Tumor 2.5 0.5 DT,OGDH Dehydrogenase Complex Palmitate Biosynthesis I Hyper 1.17 0.5 FASN (Animals) Palmitate Biosynthesis I Tumor 1.34 0.5 FASN (Animals) Anandamide Degradation Tumor 1.34 0.5 FAAH2 Fatty Acid Biosynthesis Hyper 1.17 0.5 FASN Initiation II Fatty Acid Biosynthesis Tumor 1.34 0.5 FASN Initiation II Zymosterol Biosynthesis Hyper 0.722 0.167 LBR Zymosterol Biosynthesis Tumor 2.12 0.333 HSD17B7,LBR BER pathway Hyper 0.464 0.0833 LIG1 BER pathway Tumor 1.51 0.167 POLE,LIG3 Ingenuity Pathway Analysis of predicted neoantigens with binding affinity <500nM, allele frequency >5% and mrna expression >10 TPM. Pathways with P-value<0.05 in either FAP, s or Tumors are displayed.

etable 11. Germline and somatic mutation detected in FAP and polyps Sample ID Syndrome Patient Germline Mutation Gene cdna Protein ID Validation FAP_G2 FAP FAP_1 Germline APC c.1880dupa p.ala630* Yes Germline APC c.1880dupa p.ala630* Yes FAP_G3 FAP FAP_1 Somatic p.(phe1491_ala1492delinsleu APC c.4473_4474delinsgc Pro) Somatic KRAS c.519t>c p.(=) Germline APC c.3810t>a p.cys1270* Yes FAP_G53 FAP FAP_2 Somatic APC c.2438a>g p.(asn813ser) Somatic APC c.4348c>t p.(arg1450*) FAP_G55 FAP FAP_2 Germline APC c.3810t>a p.cys1270* Yes FAP_G5 FAP FAP_3 Germline APC del exon 15 p.? No Somatic APC LOH 5q FAP_G6 FAP FAP_3 Germline APC del exon 16 p.? No Germline APC c.622c>t p.gln208* Yes FAP_G13 FAP FAP_4 Somatic APC c.4057g>t p.(glu1353*) Somatic APC c.4135g>t p.(glu1379*) FAP_G14 FAP FAP_4 Germline APC c.622c>t p.gln208* No Germline APC c.622c>t p.gln208* Yes FAP_G15 FAP FAP_4 Somatic APC c.4189_4190del p.(arg1399phefs*9) Somatic APC LOH 5q FAP_G25 FAP FAP_5 Germline APC del exons 8-10 p.? No FAP_G29 FAP FAP_6 Germline APC c.1658g>a p.trp553* Yes FAP_G39 FAP FAP_7 Germline APC c.477c>g p.tyr159* No FAP_G47 FAP FAP_8 Germline APC c.4733_4734del p.cys1578tyrfs*13 No Somatic APC LOH 5q FAP_G48 FAP FAP_8 Germline APC c.4733_4734del p.cys1578tyrfs*14 No Germline APC c.847c>t p.arg283* No FAP_G67 FAP FAP_9 Somatic APC c.4135g>t p.(glu1379*) Somatic KRAS c.35c>a p.(gly12val) FAP_G61 FAP FAP_10 Germline APC c.3810t>a p.cys1270* Yes _EBL1 _1 Germline MSH6 c.3744_3773del p.his1248_ser1257del Yes _EBL3 _2 Germline MSH2 c.687del p.ala230leufs*16 Yes _EBL5 _3 Germline PMS2 del exon 14 p.? No

Somatic MLH1 c.342_343del p.(ile115tyrfs*6) _EBL7 _4 Germline MSH2 c.1034g>a p.trp345* Yes Germline MSH2 c.1661+1g>a p.? No _EBL9 _5 Somatic MSH6 c.1340t>c p.(leu447pro) Somatic MSH6 c.3410t>c p.(met1137thr) Germline MSH2 del exons 1-6 p.? No Somatic MSH2 c.2172g>a p.(=) _EBL11 _6 Somatic APC c.2626c>t Somatic KRAS c.485a>g p.(glu162gly) Somatic CIITA c.1436c>t p.a479v _EBL13 _7 Germline MSH2 c.1216c>t p.arg406* Yes _EBL18 _8 Germline MSH6 c.3238_3239del p.leu1080valfs*12 No Germline MSH6 c.3860_3861insatta p.y1287* Yes _EBL26 _9 Somatic MSH2 c.2646_2647del p.(lys882asnfs*16) Somatic APC c.4348c>t p.(arg1450*) Germline MSH6 c.2645_2653del p.phe882* Yes _EBL20 _10 Somatic APC c.4234g>t p. Somatic APC LOH 5q _EBL23 _11 Germline MSH6 c.3699_3702del p.lys1233asnfs*6 Yes Germline MLH1 c.1279c>t p.gln427* Yes Somatic APC c.c4549t p.q1517x Somatic BRAF c.1208delc p.p403fs _T3 _12 Somatic CTNNB1 c.c134t p.s45f Somatic AXIN1 c.1922dela p.k641fs Somatic RFX5 c.56delc p.p19fs Somatic RFXAP c.297delg p.p99fs Germline MLH1 c.1918c>t p.pro640ser Yes Somatic APC c.2540dupa p.e847fs Somatic KRAS c.g38a p.g13d _T2 _13 Somatic MLH1 c.c350t p.t117m Somatic c.666_667insgatggag MSH6 p.d222fs G Somatic c.668_669insggcacaa MSH6 CTTACGTAAC p.n223_e224delinskaqltx _T1 _14 Germline MLH1 c.2059c>t p.arg687trp Yes Mutational data derived from RNA-seq analysis. Sample FAP_G53 and _EBL26 harbored APC LOH in 5q in addition to the somatic mutations.

efigure 1 A Tumor T-cell Signature Enrichment efigure 1. A. Immune profile of Lynch syndrome premalignancy and carcinomas. RNA expression levels of immune-related genes invovled in CD4, Th1/Tc1, CTL, checkpoint response, TH17, Treg, Proinflammation and Metabolism comparing polyps and tumors; B. T-cell signature enrichment score comparing andfap polyps, tumors.the graphs display mean for each group and statistically significant difference between each group using ANOVA and Tukey s Test, and multiple comparisons by Benjamini & Hochberg method. (*P<0.05, **P<0.01, ***P<0.001).

efigure 2 RNA mutation rate (Mutations/Mb) 80 60 40 20 0 0 100 200 300 400 DNA mutation rate (Mutations/Mb) R 2 = 0.339 P-value <0.0001 efigure 2. Correlation of DNA and RNA mutation rate in samples from TCGA. A total of 47 Stage I and II colorectal tumors with known MSI and hypermutation status from TCGA were selected for analysis.

efigure 3

efigure 4 CD4 FOXP3 efigure 4. Immunohistochemical staining of CD4 and FOXP3. Representative hypermutant Lynch syndrome polyp showing abundant infiltration by CD4 positive/foxp3 positive T-cells.